Publications by authors named "Yuanyuan Liu"

866 Publications

Changes in Corneal Morphology with Age in Asian Population: A Multicenter Study of 30,618 Cases.

Adv Ther 2021 Oct 10. Epub 2021 Oct 10.

Tianjin Eye Institute, Tianjin Key Lab of Ophthalmology and Visual Science, Tianjin Eye Hospital, Nankai University Affiliated Eye Hospital, No 4. Gansu Road, He-ping District, Tianjin, 300020, China.

Introduction: To evaluate normal reference ranges for corneal morphological parameters and investigate age-related changes in these parameters in Asian subjects with healthy eyes in order to provide reference data for preoperative evaluation of corneal refractive surgery and the early differential diagnosis of subclinical and asymptomatic keratoconus.

Methods: This cross-sectional, multicenter, observational study was conducted in five provinces of China, from January 2014 through October 2019. It is a retrospective analysis. Examiner-blinded clinical measurements were performed after stratification of the subjects into the following age groups: < 18, 18-30, 31-40, 41-50. We evaluated 30,618 healthy eyes of Chinese subjects who exhibited a normal corneal morphology, had no history of eye surgery or trauma, stopped wearing soft contact lenses for at least 2 weeks (rigid contact lenses for at least 4 weeks), and underwent topographic studies for both eyes on the same day.

Results: While the anterior and posterior corneal curvatures (K1 and K2) increased with age, corneal astigmatism of the anterior and posterior surfaces (ΔK) and central, minimum, and overall corneal thicknesses decreased with age. Age-related decrease of the overall corneal thickness was more obvious toward the periphery. The anterior and posterior corneal surface heights exhibited a decrease and an increase, respectively. Both index of height asymmetry (IHA) and index of vertical asymmetry (IVA) exhibited an increase with age.

Conclusions: The cornea exhibits overall thinning with age and gradually changes from a flat ellipse to an elongated ellipse in Asian individuals with healthy eyes. However, the anterior and posterior surfaces become smoother with age. Owing to the very large number of cases, these small differences are statistically significant. The results obtained are consistent with the hypothesis that a normal cornea seems to withstand quite well the effect of IOP, external pressures, and the natural cross-linking.
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http://dx.doi.org/10.1007/s12325-021-01922-4DOI Listing
October 2021

The anti-hyperuricemic effects of green alga Enteromorpha prolifera polysaccharide via regulation of the uric acid transporters in vivo.

Food Chem Toxicol 2021 Oct 20;158:112630. Epub 2021 Oct 20.

College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, 350002, China; Engineering Research Centre of Fujian-Taiwan Special Marine Food Processing and Nutrition, Ministry of Education, Fuzhou, 350002, China; Key Laboratory of Marine Biotechnology of Fujian Province, Institute of Oceanology, Fujian Agriculture and Forestry University, Fuzhou, 350002, China. Electronic address:

A novel polysaccharide obtained from Enteromorpha prolifera (EPP) was purified through diethylaminoethyl cellulose-52 and Sephadex G-75 chromatography. Fourier transform infrared spectroscopy, high-performance liquid chromatography, and nuclear magnetic resonance (NMR) spectroscopy were employed to analyse the structure of EPP. It mainly comprised rhamnose, glucuronic acid, galactose, arabinose, and xylose at a molar ratio of 20.45:12.74:10.99:5.84:1.95, and its average molecular weight was 46.56 kDa. The seven major glycosidic residues identified by NMR were as follows: →2)-α-L-Araf-(1→, →2)-α-L-Rhap-(1→, →4)-α-L-Rhap-(1→, →2,6)-β-D-Galp-(1→, →4)-β-D-GlcpA-(1→, →3,4)-β-D-GlcpA-(1→, and →4)-β-Xylp-(1→. The effect of EPP on hyperuricemic mice was determined by analysing correlative general physical parameters, renal histopathology, renal gene expressions, and gut microbiome. EPP significantly reduced serum uric acid (UA), serum blood urea nitrogen, serum xanthine oxidase (XOD), and hepatic XOD as well as improved histological parameters in hyperuricemic mice. Furthermore, mRNA and protein expression analyses showed the upregulation of UA excretion genes such as ABCG2, OAT1, and NPT1 and downregulation of UA resorption gene URAT1. Moreover, EPP maintained the stability of the intestinal flora and confirmed that Parasutterella is closely related to the regulation of hyperuricemia. This study is the first to demonstrate the anti-hyperuricemic activity of EPP and highlight its therapeutic potential for hyperuricemia-related diseases.
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http://dx.doi.org/10.1016/j.fct.2021.112630DOI Listing
October 2021

Fabrication of ZnO Ceramics with Defects by Spark Plasma Sintering Method and Investigations of Their Photoelectrochemical Properties.

Nanomaterials (Basel) 2021 Sep 26;11(10). Epub 2021 Sep 26.

State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.

ZnO, as an important semiconductor material, has attracted much attention due to its excellent physical properties, which can be widely used in many fields. Notably, the defects concentration and type greatly affect the intrinsic properties of ZnO. Thus, controllable adjustment of ZnO defects is particularly important for studying its photoelectric properties. In this work, we fabricated ZnO ceramics (ZnO(C)) with different defects through spark plasma sintering (SPS) process by varying sintering temperature and using reduction environment. The experimental results indicate that the changes of color and light absorption in as-prepared ZnO originate from the different kinds of defects, i.e., oxygen vacancies (V), interstitial zinc (Zn), and Zinc vacancies (V). Moreover, with the increase in calcination temperature, the concentration of oxygen defects and interstitial zinc defects in the ceramics increases gradually, and the conductivity of the ceramics is also improved. However, too many defects are harmful to the photoelectrochemical properties of the ceramics, and the appropriate oxygen defects can improve the utilization of visible light.
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http://dx.doi.org/10.3390/nano11102506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8537134PMC
September 2021

Tumor necrosis factor ligand-related molecule 1A maintains blood-retinal barrier via modulating SHP-1-Src-VE-cadherin signaling in diabetic retinopathy.

FASEB J 2021 Nov;35(11):e22008

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.

An impaired blood-retinal barrier (BRB) leads to diabetic macular edema (DME), which is a major complication of Diabetic retinopathy (DR). Mediators such as inflammation cause BRB breakdown. However, the explicit mechanism of its disruption is largely unknown. In this study, we identified tumor necrosis factor ligand-related molecule 1A (TL1A) as a crucial factor which protect retinal endothelial cells integrity in DR. By providing both human and mouse data, we show that TL1A is significantly decreased in the retinas of DME patients and diabetic rodents. We further demonstrate that the loss of TL1A accelerated diabetes-induced retinal barrier breakdown. TL1A supplementation protects the diabetic retina against BRB breakdown. Mechanistically, TL1A stabilize intracellular junctions and protect vascular integrity by blocking SHP1-Src-regulated VE-cadherin phosphorylation. Collectively, our findings reveal that loss of TL1A in the retina leads to increased vascular permeability in DR, and that TL1A treatment is of potential therapeutic interest for the treatment of DME.
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http://dx.doi.org/10.1096/fj.202100807RRDOI Listing
November 2021

The dominant microbial metabolic pathway of the petroleum hydrocarbons in the soil of shale gas field: Carbon fixation instead of CO emissions.

Sci Total Environ 2021 Oct 20:151074. Epub 2021 Oct 20.

College of Environment and Ecology, Chongqing University, Chongqing 400044, PR China. Electronic address:

In shale gas mining areas, indigenous microorganisms degrade organic pollutants such as petroleum hydrocarbons into carbon dioxide (CO) and water (HO) through aerobic metabolism. A large quantity of CO emissions will exacerbate the "Greenhouse effect". Based on the clean sieved soil and oil-based drilling fluid in the shale gas mining area, this experiment set three concentration gradients (3523 ± 159 mg/kg, 8715 ± 820 mg/kg and 22,031 ± 1533 mg/kg) to treat the soil, and each group was disposed for the same amount of time (63 days). By analyzing the dynamic changes of microbial diversity and the abundance of key functional genes for carbon fixation, the impact of petroleum hydrocarbons on carbon fixation potential was discovered, and the natural attenuation law of petroleum hydrocarbons in contaminated soil was explored. It provided the scientific research basis of ecology for the carbon cycle, carbon allocation, and carbon fixation in microbial remediation of petroleum hydrocarbon contaminated soil. The results obtained indicated the following: i) The removal rate of petroleum hydrocarbons under high-concentration pollution (45.33 ± 3.90%) was significantly lower than low and medium-concentration pollution. The TPH concentration removal rate of each group was the largest in the early stage of culture (1-5d), and there was no significant correlation between the TPH content and the community composition (R = 0.0736, P > 0.05). ii) Composition and function of Carbon Fixation associated microbiota were assessed by 16S rRNA sequencing and PICRUSt (phylogenetic investigation of communities by reconstruction of unobserved states) analysis. The main carbon fixation pathway in this study is the reductive citric acid cycle, because there was no shortage of enzymes that can affect subsequent reactions.
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http://dx.doi.org/10.1016/j.scitotenv.2021.151074DOI Listing
October 2021

Factors related to HIV testing frequency in MSM based on the 2011-2018 survey in Tianjin, China: a hint for risk reduction strategy.

BMC Public Health 2021 Oct 20;21(1):1900. Epub 2021 Oct 20.

Department of Epidemiology and Health Statistics, School of Public Health, Tianjin Medical University, Tianjin, China.

Background: In recent years, HIV testing has become one of the effective strategies to reduce the risk of the infection. Frequent quarterly HIV testing can be cost effective. Therefore, an in-depth study of factors related to the testing behavior of men who have sex with men (MSM) were analyzed to optimize intervention strategies.

Methods: From March 2011 to October 2018, the project was implemented in a Tianjin (China) bathhouse, and 5165 MSM were surveyed using snowball sampling. Factors related to HIV testing behavior were analyzed by ordinal logistic regression analysis after grouping according to testing frequency, and comprehensive analysis was performed.

Results: The multivariate logistic analysis showed that 6 variables including young MSM (OR = 0.67, 95% CI: 0.49-0.92, p = 0.01), low-educated MSM (OR = 0.60, 95% CI: 0.48-0.77, p < 0.0001), low HIV/AIDS knowledge (95% CI: 0.57-0.83, p < 0.0001), marital status (OR = 1.30, 95% CI: 1.07-1.57, p = 0.007), acceptance of condom promotion and distribution (OR = 14.52, 95% CI: 12.04-17.51, p < 0.0001), and frequency of condom use (p < 0.05) could link to HIV testing behaviors.

Conclusions: In order to achieve the 95-95-95 goal, target publicity, HIV/AIDS education and promotion of HIV self-testing kits should be carried out to encourage frequent HIV testing among MSM who are young (especially students), married to women, poorly educated and who are reluctant to always use condoms.
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http://dx.doi.org/10.1186/s12889-021-11948-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8527634PMC
October 2021

Isolation and purification of flavonoids from Euonymus alatus by high speed countercurrent chromatography and neuroprotective effect of rhamnazin-3-O-rutinoside in vitro.

J Sep Sci 2021 Oct 20. Epub 2021 Oct 20.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.

The flavonoids from Euonymus alatus exhibit many biological activities including significant antioxidant, anti-inflammatory, anticancer. In this work, a high speed countercurrent chromatography method for isolation and purification of flavonoids from crude extracts of Euonymus alatus was established. The effects of several solvent systems on the separation efficiency of target compounds in the extract of Euonymus alatus were studied. The solvent system composed of n-hexane-ethyl acetate-methanol-water at a volume ratio of (3:5:3:5, v/v) was chosen, in which the lower phase was used as the mobile phase at the rotation speed of 800 rpm and flow rate of 2.0 mL/min. The three flavonoids were obtained and identified as patuletin-3-O-rutinoside, rhamnazin-3-O-rutinoside and dehydrodicatechin A by MS and NMR, and the quantities of patuletin-3-O-rutinoside, rhamnazin-3-O-rutinoside and dehydrodicatechin A were 2.2 mg, 9.7 mg, and 1.8 mg respectively. The results indicated that high speed countercurrent chromatography was a simple and efficient method for isolation and purification of flavonoids from the crude extracts of Euonymus alatus. The cellular antioxidant activity experimental result indicted that rhamnazin-3-O-rutinoside could alleviate H O -induced oxidative stress. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jssc.202100607DOI Listing
October 2021

Quantitative Analysis of Myocardial Work by Non-invasive Left Ventricular Pressure-Strain Loop in Patients With Type 2 Diabetes Mellitus.

Front Cardiovasc Med 2021 1;8:733339. Epub 2021 Oct 1.

Department of Ultrasound, Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.

Type 2 diabetes mellitus (T2DM) is a common risk factor for cardiovascular diseases. The aims of this study were to evaluate the changes in the left ventricular myocardial work in T2DM patients using the left ventricular pressure-strain loop (PSL) technique, and to explore the risk factors for the left ventricular myocardial work impairment. Fifty patients with T2DM and 50 normal controls (NCs) were included in the study. In addition to conventional echocardiography and two-dimensional speckle tracking echocardiography, the left ventricular myocardial work parameters were measured using PSL technology. The absolute value for global longitudinal strain (GLS), global work index (GWI) and, global constructive work (GCW) were significantly decreased in the T2DM group ( < 0.05), while the left ventricular ejection fraction (LVEF) was not significantly different between the T2DM and NC groups. Multivariable linear regression analysis showed that hemoglobin A1c (HbA1c) was independently related to GWI (β = -0.452, < 0.05), while HbA1c and the diabetes duration were independently related to GCW (β = -0.393, < 0.05 and β = -0.298, < 0.05, respectively). Changes in the left ventricular myocardial systolic function in T2DM patients were identified using PSL technology. HbA1c was shown to be an independent risk factor affecting GWI, while HbA1c and diabetes duration were demonstrated to be independent risk factors affecting GCW.
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http://dx.doi.org/10.3389/fcvm.2021.733339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517392PMC
October 2021

Synergistic killing effects of PD-L1-CAR T cells and colorectal cancer stem cell-dendritic cell vaccine-sensitized T cells in ALDH1-positive colorectal cancer stem cells.

J Cancer 2021 13;12(22):6629-6639. Epub 2021 Sep 13.

The First People's Hospital of Hefei/The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, P.R. China.

Cancer stem cells (CSCs) are characterized by self-renewal and unlimited proliferation, providing a basis for tumor occurrence, metastasis, and recurrence. Because CSCs are highly resistant to conventional chemotherapy and radiotherapy, various immunotherapies, particularly chimeric antigen receptor T cell (CAR-T) therapy and dendritic cell (DC)-based vaccine therapy, are currently being developed. Accordingly, in this study, we evaluated programmed cell death ligand-1 (PD-L1) expression in colorectal CSCs (CCSCs) and non-CCSCs and designed a combination immunotherapy synchronously utilizing PD-L1-CAR-T cells together with CCSC-DC vaccine-sensitized T cells for the treatment of colorectal cancer. PD-L1-CAR-T cells specifically recognized the PD-L1 molecule on CCSCs by binding to the extracellular domain of programmed cell death-1. The CCSC-DC vaccine was prepared using CCSC lysates. We found that aldehyde dehydrogenase 1 (ALDH1)-positive CCSCs were abundant in samples from patient tumor tissues and cancer cell lines. Moreover, PD-L1 was highly expressed in ALDH1-positive CCSCs compared with that in non-CCSCs. Monotherapy with PD-L1-CAR-T cells or CCSC-DC vaccine only elicited moderate tumor remission both and . However, combination therapy markedly killed cancer cells and relieved the tumor burden in mice. Our findings may provide a novel strategy for the clinical treatment of colorectal malignancy.
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http://dx.doi.org/10.7150/jca.62123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517999PMC
September 2021

Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia.

Leukemia 2021 Oct 11. Epub 2021 Oct 11.

Department of Hematology, Southwest Hospital, Third Military Medical University (Army medical university), Chongqing, China.

FZR1 has been implicated as a master regulator of the cell cycle and quiescence, but its roles and molecular mechanisms in the pathogenesis of severe aplastic anemia (SAA) are unclear. Here, we report that FZR1 is downregulated in SAA HSCs compared with healthy control and is associated with decreased quiescence of HSC. Haploinsufficiency of Fzr1 shows impaired quiescence and self-renewal ability of HSC in two Fzr1 heterozygous knockout mouse models. Mechanistically, FZR1 insufficiency inhibits the ubiquitination of RUNX1 protein at lysine 125, leading to the accumulation of RUNX1 protein, which disturbs the quiescence of HSCs in SAA patients. Moreover, downregulation of Runx1 reversed the loss of quiescence and impaired long-term self-renew ability in Fzr1 HSCs in vivo and impaired repopulation capacity in BM from SAA patients in vitro. Our findings, therefore, raise the possibility of a decisive role of the FZR1-RUNX1 pathway in the pathogenesis of SAA via deregulation of HSC quiescence.
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http://dx.doi.org/10.1038/s41375-021-01445-5DOI Listing
October 2021

The association between long-term exposure to ambient fine particulate matter and glaucoma: A nation-wide epidemiological study among Chinese adults.

Int J Hyg Environ Health 2021 Oct 8;238:113858. Epub 2021 Oct 8.

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Medical University, Tianjin, 300070, China. Electronic address:

Background: A growing body of evidence has confirmed the association between fine particulate matter (PM) and ocular diseases, but little is known on the effect of long-term PM exposure on glaucoma.

Methods: A national cross-sectional study of the Rural Epidemiology for Glaucoma was conducted in 10 provinces of China, and 33,701 adults aged 40 years or more were included. A satellite-based model at 1-km resolution level was used to estimate PM concentrations which were assigned to each participant according to geocoded home addresses. Logistic regression model was performed to investigate associations of long-term PM exposure with glaucoma and its subtypes.

Results: Estimated PM concentrations ranged from 28.0 to 96.4 μg/m. For each 10 μg/m increment in PM, the adjusted odds ratios (ORs) were 1.07 (95% CI: 1.00-1.15) and 1.14 (95% CI: 1.02-1.26) for glaucoma and primary angle-closure glaucoma (PACG), respectively. A positive but non-significant association (OR = 1.05, 95% CI: 0.92-1.18) was detected between long-term exposure to PM and odds of primary open-angle glaucoma. The middle aged residents and non-smokers were more sensitive to the adverse effects of PM.

Conclusions: Long-term PM exposure was associated with glaucoma and PACG in Chinese adults, which provided new insights on adverse ophthalmic effect of PM.
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http://dx.doi.org/10.1016/j.ijheh.2021.113858DOI Listing
October 2021

Gene Expression Subtyping Reveals Immune alterations:TCGA Database for Prognosis in Ovarian Serous Cystadenocarcinoma.

Front Mol Biosci 2021 24;8:619027. Epub 2021 Sep 24.

Department of Radiotherapy and Oncology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, China.

Serous ovarian cancer is the most common and primary death type in ovarian cancer. In recent studies, tumor microenvironment and tumor immune infiltration significantly affect the prognosis of ovarian cancer. This study analyzed the four gene expression types of ovarian cancer in TCGA database to extract differentially expressed genes and verify the prognostic significance. Meanwhile, functional enrichment and protein interaction network analysis exposed that these genes were related to immune response and immune infiltration. Subsequently, we proved these prognostic genes in an independent data set from the GEO database. Finally, multivariate cox regression analysis revealed the prognostic significance of TAP1 and CXCL13. The genetic alteration and interaction network of these two genes were shown. Then, we established a nomogram model related to the two genes and clinical risk factors. This model performed well in Calibration plot and Decision Curve Analysis. In conclusion, we have obtained a list of genes related to the immune microenvironment with a better prognosis for serous ovarian cancer, and based on this, we have tried to establish a clinical prognosis model.
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http://dx.doi.org/10.3389/fmolb.2021.619027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497788PMC
September 2021

Creation of a New Explosive Injury Equipment to Induce a Rabbit Animal Model of Closed Globe Blast Injury Gas Shock.

Front Med (Lausanne) 2021 23;8:749351. Epub 2021 Sep 23.

Department of Ophthalmology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, China.

To establish a rabbit animal model of closed globe blast injury with an application of self-developed explosive injury equipment, we tend to explore the anatomic and pathological changes of eyes under different gas pressure. The device comprises of high-pressure air source compression pump, air channel, and gas shock. There were 36 healthy bluish blue rabbits exposed to one of five blast pressures (500, 1,000, 1,500, 2,000, and 5,000 Kpa). Slit lamp microscope, B-mode ultrasonography, fundus photography, optical coherence tomography (OCT), and intraocular pressure (IOP) examination were performed at 0-, 1-, 3-, and 7-days post exposure, while gross histopathology was assessed with H&E stain at 7 days. The contralateral eyes and non-blast exposed rabbits were used as controls. Definitive evidence of closed globe blast injury was obtained. Corneal edema and hyphema were observed in the models under all pressures with no full-thickness globe injury, or lens rupture, as the severity was pressure independent. There was no obvious retinal abnormality on B ultrasound or OCT scan, while light vitreous hemorrhage, commotio retinae, and heavy retinal pigmentation presented on one eye, respectively, in the eyes exposed to 5,000 Kpa. Increased retinal thickness with disorganizations on the retinal ganglion cell (RGC) layer and RGC apoptosis in groups under higher pressure (>500 Kpa). IOP of injured eyes were statistically decreased at day 1 and 7 post injury ( < 0.05). Conclusively, the rabbit animal model induced by self-developed equipment could mimic the clinical features of closed ocular blast injury successfully that was feasible and easy to operate. This will be a new rabbit animal model for investigating mechanisms and new therapeutic interventions of closed globe blast injury in the future.
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http://dx.doi.org/10.3389/fmed.2021.749351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8495021PMC
September 2021

Subxiphoid thoracoscopic thymectomy for myasthenia gravis.

Interact Cardiovasc Thorac Surg 2021 Oct 9. Epub 2021 Oct 9.

Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Xuzhou, China.

We investigated the efficacy of subxiphoid thoracoscopic thymectomy in patients with myasthenia gravis. The data of 37 consecutive cases were reviewed. 2 cases of postoperative myasthenia gravis crisis and 4 cases of residual mediastinal fat tissue were recorded. Moreover, 29 patients presented the neurological outcomes, and complete stable remission was achieved in 5 (17.2%) cases. Subxiphoid thymectomy is technically feasible. High-quality evidence is warranted before this approach can be recommended.
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http://dx.doi.org/10.1093/icvts/ivab262DOI Listing
October 2021

The ligand effect of atomically precise gold nanoclusters in tailoring catalytic properties.

Nanoscale 2021 Oct 21;13(40):16847-16859. Epub 2021 Oct 21.

School of Safety Engineering, China University of Mining and Technology, Xuzhou 221116, China.

It is well known that surface ligands are vital layers for ligand-protected Au nanoclusters. Improving the knowledge of the relationship between ligands and catalytic properties is a forefront research topic for Au nanoclusters. Enormous effort has been devoted to realizing the ligand effect in synthesis, including well-controlled sizes and shapes as well as structural transformation. However, the crucial function of surface ligands has not been addressed yet in catalytic reactions. Here, this review mainly aims to summarize the recent progress concerning the influence of surface ligand layers on catalytic activity and selectivity, based on the various types of ligand protected Au nanoclusters. Besides, the potential challenges and opportunities of Au nanoclusters are indicated, mainly in terms of surface ligands to guide the improvement of catalytic performances.
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http://dx.doi.org/10.1039/d1nr05232bDOI Listing
October 2021

Phase unwrapping algorithm based on a rank information filter.

Appl Opt 2021 Aug;60(22):6648-6658

A robust phase unwrapping algorithm based on a rank information filter is proposed to retrieve the unambiguous unwrapped phase from noisy wrapped phase images. First, a recursive phase unwrapping program, based on a rank information filter, is proposed to transform the problem of phase unwrapping for wrapped phase into the problem of the state estimation for state variables under the framework of a rank information filter, where a local phase gradient estimator based on the amended matrix pencil model (AMPM) is used to obtain phase gradient information required by the recursive phase unwrapping program. Second, an efficient path-following strategy based on heap-sort is used to guide the phase unwrapping path, which ensures that the recursive phase unwrapping program based on a rank information filter unwraps wrapped phase images along the path from high-quality pixels to low-quality pixels. Finally, the results obtained from synthetic data and experimental measured data demonstrate the effectiveness of the proposed method and show this method can obtain robust solutions from noisy wrapped phase images.
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http://dx.doi.org/10.1364/AO.428181DOI Listing
August 2021

Anlotinib Inhibits PFKFB3-Driven Glycolysis in Myofibroblasts to Reverse Pulmonary Fibrosis.

Front Pharmacol 2021 16;12:744826. Epub 2021 Sep 16.

Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Idiopathic pulmonary fibrosis (IPF) is a fatal disease in which the normal alveolar network is gradually replaced by fibrotic scars. Current evidence suggests that metabolic alterations correlate with myofibroblast activation in IPF. Anlotinib has been proposed to have antifibrotic effects, but the efficacy and mechanisms of anlotinib against lung fibrosis have not been systematically evaluated. The antifibrotic effects of anlotinib were evaluated in bleomycin-induced mouse models and transforming growth factor-beta 1 (TGF-β1)-stimulated lung fibroblasts. We measured lactate levels, 2-NBDG glucose uptake and the extracellular acidification rate (ECAR) to assess glycolysis in fibroblasts. RNA-protein coimmunoprecipitation (RIP) and polysome analyses were performed to investigate novel mechanisms of glycolytic reprogramming in pulmonary fibrosis. We found that anlotinib diminished myofibroblast activation and inhibited the augmentation of glycolysis. Moreover, we show that PCBP3 posttranscriptionally increases PFKFB3 expression by promoting its translation during myofibroblast activation, thus promoting glycolysis in myofibroblasts. Regarding mechanism, anlotinib exerts potent antifibrotic effects by downregulating PCBP3, reducing PFKFB3 translation and inhibiting glycolysis in myofibroblasts. Furthermore, we observed that anlotinib had preventative and therapeutic antifibrotic effects on bleomycin-induced pulmonary fibrosis. Therefore, we identify PCBP3 as a protein involved in the regulation of glycolysis reprogramming and lung fibrogenesis and propose it as a therapeutic target for pulmonary fibrosis. Our data suggest that anlotinib has antifibrotic effects on the lungs, and we provide a novel mechanism for this effect. Anlotinib may constitute a novel and potent candidate for the treatment of pulmonary fibrosis.
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http://dx.doi.org/10.3389/fphar.2021.744826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8481786PMC
September 2021

Theoretical analysis of a contactless transportation system for cylindrical objects based on ultrasonic levitation.

J Acoust Soc Am 2021 Sep;150(3):1682

Chair of Vibroacoustics of Vehicles and Machines, Technical University of Munich, Boltzmann Strasse 15, 85748 Garching, Germany.

Contactless transportation systems based on near-field acoustic levitation have the benefit of compact design and easy control which are able to meet the cleanliness and precision demands required in precision manufacturing. However, the problems involved in contactless positioning and transporting cylindrical objects have not yet been addressed. This paper introduces a contactless transportation system for cylindrical objects based on grooved radiators. A groove on the concave surface of the radiator produces an asymmetrical pressure distribution which results in a thrusting force to drive the levitator horizontal movement. The pressure distribution between the levitator and the radiator is acquired by solving the Reynolds equation. The levitation and the thrusting forces are obtained by integrating the pressure and the pressure gradient over the concave surface, respectively. The predicted results of the levitation force agree well with experimental observations from the literature. Parameter studies show that the thrusting force increases and converges to a stable value as the groove depth increases. An optimal value for the groove arc length is found to maximize the thrusting force, and the thrusting force increases as the groove width, the radiator vibration amplitude, and the levitator weight increase.
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http://dx.doi.org/10.1121/10.0006208DOI Listing
September 2021

BiVO Ceramic Photoanode with Enhanced Photoelectrochemical Stability.

Nanomaterials (Basel) 2021 Sep 15;11(9). Epub 2021 Sep 15.

State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.

Monoclinic bismuth vanadate (BiVO) is an attractive material with which to fabricate photoanodes due to its suitable band structure and excellent photoelectrochemical (PEC) performance. However, the poor PEC stability originating from its severe photo-corrosion greatly restricts its practical applications. In this paper, pristine and Mo doped BiVO ceramics were prepared using the spark plasma sintering (SPS) method, and their photoelectrochemical properties as photoanodes were investigated. The as-prepared 1% Mo doped BiVO ceramic (Mo-BVO (C)) photoanode exhibited enhanced PEC stability compared to 1% Mo doped BiVO films on fluorine doped Tin Oxide (FTO) coated glass substrates (Mo-BVO). Mo-BVO (C) exhibited a photocurrent density of 0.54 mA/cm and remained stable for 10 h at 1.23 V vs. reversible hydrogen electrode (RHE), while the photocurrent density of the Mo-BVO decreased from 0.66 mA/cm to 0.11 mA/cm at 1.23 V vs. RHE in 4 h. The experimental results indicated that the enhanced PEC stability of the Mo-BVO (C) could be attributed to its higher crystallinity, which could effectively inhibit the dissociation of vanadium in BiVO during the PEC process. This work may illustrate a novel ceramic design for the improvement of the stability of BiVO photoanodes, and might provide a general strategy for the improvement of the PEC stability of metal oxide photoanodes.
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http://dx.doi.org/10.3390/nano11092404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8466786PMC
September 2021

Therapeutic Potential of Sodium Channel Blockers as a Targeted Therapy Approach in -Associated Episodic Ataxia and a Comprehensive Review of the Literature.

Front Neurol 2021 9;12:703970. Epub 2021 Sep 9.

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Among genetic paroxysmal movement disorders, variants in ion channel coding genes constitute a major subgroup. Loss-of-function (LOF) variants in , the gene coding for K1.1 channels, are associated with episodic ataxia type 1 (EA1), characterized by seconds to minutes-lasting attacks including gait incoordination, limb ataxia, truncal instability, dysarthria, nystagmus, tremor, and occasionally seizures, but also persistent neuromuscular symptoms like myokymia or neuromyotonia. Standard treatment has not yet been developed, and different treatment efforts need to be systematically evaluated. Personalized therapeutic regimens tailored to disease-causing pathophysiological mechanisms may offer the specificity required to overcome limitations in therapy. Toward this aim, we (i) reviewed all available clinical reports on treatment response and functional consequences of variants causing EA1, (ii) examined the potential effects on neuronal excitability of all variants using a single compartment conductance-based model and set out to assess the potential of two sodium channel blockers (SCBs: carbamazepine and riluzole) to restore the identified underlying pathophysiological effects of K1.1 channels, and (iii) provide a comprehensive review of the literature considering all types of episodic ataxia. Reviewing the treatment efforts of EA1 patients revealed moderate response to acetazolamide and exhibited the strength of SCBs, especially carbamazepine, in the treatment of EA1 patients. Biophysical dysfunction of K1.1 channels is typically based on depolarizing shifts of steady-state activation, leading to an LOF of variant channels. Our model predicts a lowered rheobase and an increase of the firing rate on a neuronal level. The estimated concentration dependent effects of carbamazepine and riluzole could partially restore the altered gating properties of dysfunctional variant channels. These data strengthen the potential of SCBs to contribute to functional compensation of dysfunctional K1.1 channels. We propose riluzole as a new drug repurposing candidate and highlight the role of personalized approaches to develop standard care for EA1 patients. These results could have implications for clinical practice in future and highlight the need for the development of individualized and targeted therapies for episodic ataxia and genetic paroxysmal disorders in general.
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http://dx.doi.org/10.3389/fneur.2021.703970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8459024PMC
September 2021

: A Comprehensive Review of its Botany, Phytochemistry, Pharmacology, and Clinical Applications.

Am J Chin Med 2021 Sep 23:1-46. Epub 2021 Sep 23.

School of Pharmacy, Shaanxi University of Chinese Medicine, Xian Yang, Shaanxi 712046, P. R. China.

Rehd. et Wils () is a single species of genus, family, and it is a famous medicinal herb mostly growing in southern China, China Taiwan and Vietnam. is usually used for the treatments of hepatitis, Alzheimer's disease, renal transplantation, osteoporosis, and insomnia. In present studies, approximately 310 natural constituents have been isolated from , including lignans, triterpenes, volatile oils, and polysaccharides, which were mainly obtained from the fruits and stems of . Pharmocological studies have shown that the extracts and monomeric compounds of possessed wide-range bioactivities, such as antitumor, anti-oxidant, anti-inflammatory, osteoblastic, immune regulation, neuroprotective, kidney protection, hepatoprotective, and antiviral activities. However, resource availability, quality control measures, in-depth pharmacological study, and clinical application are still insufficient and deserve further studies. This review systematically summarized literatures on the botany, phytochemistry, pharmacology, development utilization, and clinical application of , in hopes of provide a useful reference for researchers for further studies of this plant.
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http://dx.doi.org/10.1142/S0192415X21500749DOI Listing
September 2021

Prevalence of Dual-Positivity for Both Hepatitis B e Antigen and Hepatitis B e Antibody Among Hospitalized Patients with Chronic Hepatitis B Virus Infection.

Int J Gen Med 2021 16;14:5759-5770. Epub 2021 Sep 16.

Department of Infectious Diseases, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China.

Objective: The detection of dual-positivity for both hepatitis B e antigen (HBeAg) and hepatitis B e antibody (anti-HBe) is not typically performed for patients with hepatitis B virus (HBV). This cross-sectional study was designed to figure out the prevalence of dual-positivity for both HBeAg and anti-HBe (DEP) among hospitalized patients with chronic hepatitis B virus infection (C-HBVI).

Patients And Methods: Data from 2820 cases with C-HBVI from two centers in China were retrospectively analyzed. Univariate and multivariate logistic regression analyses were undertaken to identify the risk factors for liver fibrosis (LF) and acute-on-chronic liver failure (ACLF).

Results: There were 165 (5.9%), 688, and 1903 patients in DEP, HBeAg+/anti-HBe-, and HBeAg-/anti-HBe+ groups, respectively. The DEP patients' median age was 43.6 years old and 71.5% of them were male. They had higher levels of alanine transaminase, total bilirubin, and international normalized ratio. Furthermore, DEP cases had a higher proportion of liver cirrhosis, and it was associated with non-invasive testing of LF, including aspartate transaminase (AST)-to-platelet ratio index (APRI) >1.5 (odds ratio (OR) = 1.96, 95% confidence interval (CI): 1.27-3.03, = 0.002) and fibrosis-4 (FIB-4) score >1.45 (OR = 2.07, 95% CI: 1.28-3.34, = 0.003). DEP also contributed to the elevated risk of ACLF (OR = 4.80, 95% CI: 2.02-11.39, < 0.001).

Conclusion: DEP cases are at higher risks of LF and ACLF than other patients with HBV infection. A fast diagnosis and an active monitoring of liver diseases for DEP patients are extremely vital.
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http://dx.doi.org/10.2147/IJGM.S328714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8454426PMC
September 2021

Lipoxin A4 inhibits ovalbumin-induced airway inflammation and airway remodeling in a mouse model of asthma.

Chem Biol Interact 2021 Nov 16;349:109660. Epub 2021 Sep 16.

Department of Respiratory Medicine, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, 271000, China. Electronic address:

Asthma is a chronic respiratory disease, which is characterized by airway inflammation, remodeling and airway hyperresponsiveness. Airway remodeling is caused by long-term inflammation of the airways. Lipoxin A4 (LXA4) is a natural eicosanoid with powerful anti-inflammatory properties, and has been shown to serve a critical role in orchestrating pulmonary inflammation and airway hyper-responsiveness in asthmatic mice. However, its effect on airway remodeling is unknown. Female BALB/c mice were used to establish a mouse model of asthma which were sensitized and challenged by ovalbumin (OVA). LXA4 was intranasally administrated prior to the challenge. The results of our study indicated that LXA4 suppressed the OVA-induced inflammatory cell infiltration and T helper type 2 (Th2) cytokines secretion in the mouse model of asthma. Characteristics of airway remodeling, such as thickening of the bronchial wall and smooth muscle, overdeposition of collagen, and overexpression of α-smooth muscle actin (α-SMA) and collagen-I were reversed by LXA4. Furthermore, LXA4 suppressed the aberrant activation of the signal transducer and activator of transcription 3 (STAT3) pathway in the lung tissues of asthmatic mice. In conclusion, these findings demonstrated that LXA4 alleviated allergic airway inflammation and remodeling in asthmatic mice, which may be related to the inhibition of STAT3 pathway.
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http://dx.doi.org/10.1016/j.cbi.2021.109660DOI Listing
November 2021

Modulating the biofunctionality of enzyme-MOF nanobiocatalyst through structure-switching aptamer for continuous degradation of BPA.

Colloids Surf B Biointerfaces 2021 Sep 14;208:112099. Epub 2021 Sep 14.

School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu Province, China. Electronic address:

Encapsulating enzyme within MOF (enzyme-MOF) gives rise to new opportunity to improve the fragility of enzyme, but practical application of enzyme-MOF composite is far from being realized. The development of a novel enzyme-MOF composite system should simultaneously guarantee the enhanced activity and controllably complete recycling, and only in this way can we efficiently and economically utilize the enzyme-MOF composite. Herein, we addressed all these fundamental limitations of current enzyme-MOF composite by establishing aptamer-functionalized enzyme-MOF composite ([email protected]). [email protected] relied on automatic structure switch of aptamer-target binding and aptamer-cDNA (complementary DNA) hybridization, achieving effectiveness in self-enriching substrate around [email protected] to boost enzymatic activity first, subsequently hybridizing spontaneously with magnetically controllable cDNA sequence ([email protected]) to completely recover the [email protected], where preferentially capturing substrate could further induce the release of the hybridized [email protected] for automatically starting the cyclic enzyme catalysis. A 5.6-fold enhancement in the catalytic efficiency for BPA degradation was endowed, and 94.7% catalytic activity was retained for 8 consecutive degradations of BPA, both of which were even more significant than HRP-ZIF-8. Additionally, remarkable stability of [email protected] was afforded by dual-layer protection of ZIF-8 and P1 in denaturing conditions. Taking the possibility of discovering an aptamer for any target into account, the aptamer-functionalized enzyme-MOF composites provide a generic and simple guide for simultaneously boosting enzymatic activity and controllably full recycling the enzyme-MOF systems, accelerating their commercial utilizations.
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http://dx.doi.org/10.1016/j.colsurfb.2021.112099DOI Listing
September 2021

The effect of systemic antidepressant treatments in early stage on neurocognitive function of euthymic bipolar patients initiated with a depressive onset: An observational, cross-sectional, single-blind study protocol.

Brain Behav 2021 Sep 14:e32360. Epub 2021 Sep 14.

School of Nursing, Sun Yat-sen University, Guangzhou, China.

Objectives: Patients with bipolar disorder (BD) have a wide range of neurocognitive dysfunction even in euthymic state, leading to impaired psychosocial function and reduced quality of life. However, the understanding on risk factors related to neurocognitive impairment in such group of people is limited. In view of significantly delayed diagnosis of BD and common use of antidepressants prior to the BD diagnosis, the study aims to clarify whether systemic antidepressant use in early stage, defined as from the initial depressive episode to the diagnosis of BD, could impact neurocognitive function of euthymic bipolar patients.

Methods: It is an observational, cross-sectional, single-blind trial, making a comparison in neurocognitive function between euthymic bipolar patients who had a depressive episode as initial onset and being with and without systemic antidepressant treatments in early stage (n = 62 and 62, respectively); secondary outcomes include the impact of systemic antidepressant use on global function, quality of life, sleep quality, positive and negative affect, and peripheral level of neuron-specific enolase.

Discussion: The study will provide a comprehensive and in-depth understanding on the effect of systemic antidepressant treatments in early stage in such group of patients. It is expected to better guide the related prevention and treatment work of BD management.

Trial Registration: The study was registered on Clinicaltrials.gov with protocol ID (TJAH2020-18) and clinicaltrials.gov ID (NCT04564573).
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http://dx.doi.org/10.1002/brb3.2360DOI Listing
September 2021

Improvement in salt tolerance of Iris pseudacorus L. in constructed wetland by exogenous application of salicylic acid and calcium chloride.

J Environ Manage 2021 Dec 9;300:113703. Epub 2021 Sep 9.

College of Environmental Science and Engineering, Qingdao University, Qingdao, China. Electronic address:

Wetland plants play a major role in the process of wastewater treatment in constructed wetlands (CWs). The inhibitory effect of salt stress on plants may reduce the performance of CWs. In this study, salicylic acid (SA) and/or calcium ion (Ca) were used for root pretreatment to alleviate the salt stress in Iris pseudacorus L. The results showed that root pretreatment with SA and/or Ca improved the response of Iris pseudacorus L. to salinity by increasing growth, photosynthetic pigments, Pro content, enzymes activities and K content. In addition, SA and/or Ca application in saline conditions decreased the relative conductivity and content of malondialdehyde. RNA-seq analysis showed the expression of hormone signaling genes, potassium ion transporter genes, oxidative stress genes and photosynthesis genes were up-regulated after pretreating with SA and CaCl. In conclusion, the addition of SA and Ca could improve the saline wastewater treatment efficiency of CWs by enhancing the salt tolerance of Iris pseudacorus L.
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http://dx.doi.org/10.1016/j.jenvman.2021.113703DOI Listing
December 2021

Extracellular HSP90α Interacts With ER Stress to Promote Fibroblasts Activation Through PI3K/AKT Pathway in Pulmonary Fibrosis.

Front Pharmacol 2021 23;12:708462. Epub 2021 Aug 23.

Chronic Airways Diseases Laboratory, Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Pulmonary fibrosis is characterized by alveolar epithelial cell injury, lung fibroblast proliferation, differentiation, and extracellular matrix (ECM) deposition. Our previous study indicated that extracellular HSP90α (eHSP90α) promotes pulmonary fibrosis by activating the MAPK signaling pathway. Thus, treatment with 1G6-D7 (a selective HSP90α monoclonal antibody) to antagonize eHSP90α could effectively ameliorate fibrosis. This study aimed to elucidate the mechanism underlying the effects of eHSP90α in pulmonary fibrosis by focusing on its link with endoplasmic reticulum (ER) stress. Our results showed that eHSP90α promoted lung fibroblast differentiation by activating ER stress. Treatment with the ER stress inhibitor tauroursodeoxycholate (TUDCA) or glucose-regulated protein 78 kDa (GRP78) depletion significantly abrogated the effect of eHSP90α on ER stress and fibroblast activation. In addition, eHSP90α induced ER stress in fibroblasts the phosphoinositide-4,5-bisphosphate 3-kinase (PI3K)-protein kinase B (AKT) signaling pathway, which could be blocked by the PI3K/AKT inhibitor LY294002, and blockade of eHSP90α by 1G6-D7 markedly inhibited ER stress in the model, indicating preventive and therapeutic applications. Intriguingly, we observed that TUDCA effectively reduced the secretion of eHSP90α and . In conclusion, this study shows that the interaction between eHSP90α and ER stress plays a crucial role in pulmonary fibrosis, indicating a positive feedback in lung fibroblasts. Targeting eHSP90α and alleviating fibroblast ER stress may be promising therapeutic approaches for pulmonary fibrosis.
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http://dx.doi.org/10.3389/fphar.2021.708462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8420756PMC
August 2021

Boron containing metal-organic framework for highly selective photocatalytic production of HO by promoting two-electron O reduction.

Mater Horiz 2021 Oct 4;8(10):2842-2850. Epub 2021 Oct 4.

State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China.

A zirconium-based metal-organic framework containing boron (UiO-66-B) is prepared, which displays efficient photocatalytic HO production. The HO evolution rate is about 1002 μmol g h, much higher than that of most known photocatalysts. Pristine UiO-66 displays a much lower activity (314 μmol g h) under the same conditions, suggesting the significant role of boron. Both theoretical calculations and the combined experimental results verify the above conclusion, and the role of boron is ascribed to the following aspects: (1) enhanced O adsorption, (2) highly selective proton-coupled two-electron transfer, (3) faster carrier separation and surface charge transfer, and (4) faster generation but slower decomposition rates of HO. This work highlights key factors in the two-electron O reduction reaction (ORR), presents a deeper understanding of the role of boron in enhancing HO production, and provides a new strategy for designing photocatalysts with excellent HO evolution efficiency.
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http://dx.doi.org/10.1039/d1mh00869bDOI Listing
October 2021

Association Between Echocardiographic Non-invasive Myocardial Work Indices and Myocardial Fibrosis in Patients With Dilated Cardiomyopathy.

Front Cardiovasc Med 2021 16;8:704251. Epub 2021 Aug 16.

Department of Ultrasound, The People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Fuwai Central China Cardiovascular Hospital, Zhengzhou, China.

To analyze the association between global myocardial work indices evaluated by non-invasive left ventricular (LV) pressure-strain loop (PSL) and LV myocardial fibrosis in patients with dilated cardiomyopathy (DCM). A total of 57 patients with DCM were included in this prospective study. Global work index (GWI), global constructive work (GCW), global wasted work (GWW), global work efficiency (GWE) and global longitudinal strain (GLS) were measured using LVPSL. LV volumes and LV ejection fraction (LVEF) were evaluated using cardiac magnetic resonance imaging (CMRI), LV myocardial fibrosis was estimated at CMRI by qualitative assessment of late gadolinium enhancement (LGE). According to the CMRI, the studied population was divided into two groups, namely: patients without LGE (LGE-) and patients with LGE (LGE+). The LGE+ group presented with increased age, LV end systolic volume (LVESV) index and reduced GWI, GCW, GWE, GLS, CMRI-derived LVEF (LVEF), the differences between the two groups were statistically significant ( < 0.05). After correcting for age and LVESV index, LVEF, GLS, GWI, GCW, and GWE retained independent associations with LV myocardial fibrosis. According to receiver operating characteristics (ROC) analysis, LVEF, and GCW showed larger AUC and higher accuracy, sensitivity, and specificity than GLS, the accuracy of predicting LV myocardial fibrosis ranged from high to low as: LVEF, GCW, GWE, GWI, and GLS. LVEF, GWI, GCW, GWE, and GLS remained significant predictors of LV myocardial fibrosis. LVEF, and GCW appeared to better predict LV myocardial fibrosis compared with GLS.
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http://dx.doi.org/10.3389/fcvm.2021.704251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415625PMC
August 2021

Case Report: Rare Pulmonary Sclerosing Pneumocytoma: Large, Multiple, Metastatic, and Fatal.

Front Med (Lausanne) 2021 16;8:661032. Epub 2021 Aug 16.

Department of Thoracic Surgery, Henan Provincial Chest Hospital, Zhengzhou, China.

Pulmonary sclerosing pneumocytoma (PSP) is a rare benign or low-grade malignant tumor, but it has the potential to present with multiple lesions, lymph node metastasis, extra-pulmonary metastasis, recurrence and even cause death. Herein, a case of PSP that was huge, presented with multiple lesions and had lymph node as well as extrapulmonary metastases (liver, abdominal cavity, bones) is reported for the first time. This patient was also the first one to die of respiratory and circulatory failure caused by the PSP tumor and its metastases which compressed the mediastinal tissue.
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http://dx.doi.org/10.3389/fmed.2021.661032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415542PMC
August 2021
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