Publications by authors named "Yuanchun Zhang"

7 Publications

  • Page 1 of 1

Long-term clinical safety and efficacy of drug-coated balloon in the treatment of in-stent restenosis: A meta-analysis and systematic review.

Catheter Cardiovasc Interv 2020 08 12;96(2):E129-E141. Epub 2019 Nov 12.

Department of Cardiology, The Dongguan Affiliated Hospital (Dongguan 5th People's Hospital), Jinan University School of Medicine, Dongguan, China.

Objectives: The aim of this study was to evaluate the long-term clinical safety and efficacy of drug-coated balloon (DCB) in the treatment of in-stent restenosis (ISR).

Background: There is a long-term safety issue in peripheral arterial disease patients treated with paclitaxel-coated balloon, this has also raised concerns on DCB in coronary intervention.

Methods: Nine randomized controlled trials (RCTs) and nine observational studies (OSs) were included with a total of 3,782 patients (1,827 in the DCB group, 1,955 in the drug-eluting stent [DES] group) being analyzed. The primary outcome measure-major adverse cardiovascular events (MACEs), target lesion revascularization (TLR), target vessel revascularization (TVR), myocardial infarction (MI), cardiac death (CD), stent thrombosis (ST), all-cause death (AD), and coronary angiography outcomes included late lumen loss (LLL), minimum luminal diameter (MLD), diameter stenosis (DS) were analyzed.

Results: DCB treatment significantly reduced the LLL (MD: -0.13; [CI -0.23 to -0.03], p = .01). No difference was found for MLD (MD: -0.1; [CI -0.24 to 0.04], p = .17) and DS% (RR = 0.98 [CI 0.80-1.20], p = .86). There was no significant difference in TLR, TVR, MI, CD, ST, AD, and the overall incidence of MACEs between the two groups up to 3 years follow-up. Subgroup analysis for different type of ISR and DES showed no significant difference in the incidence of endpoints, and there is no difference when considering RCTs or OSs only.

Conclusions: The safety and efficacy of the DCB and DES in the treatment of ISR is comparable at up to 3 years follow-up.
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August 2020

Degradation of acetaminophen with ferrous/copperoxide activate persulfate: Synergism of iron and copper.

Water Res 2018 12 20;146:232-243. Epub 2018 Sep 20.

Department of Environmental Science and Engineering, Huaqiao University, Xiamen, 361021, China; Fujian Provincial Research Center of Industrial Wastewater Biochemical Treatment (Huaqiao University), Xiamen, 361021, China. Electronic address:

To enhance the advanced oxidation process based on persulfate, CuO was introduced into the Fe/PS system to achieve a synergistic effect between Fe and Cu. Results showed that Fe was able to adsorb onto the CuO surface to form Fe(II) and further reduced Cu(II) into Cu(I), which can further release into the solution to participate in oxidation reactions. In this case, SO can be generated via Fe and Cu reactions with PS and ·OH from Cu reaction with dissolved oxygen (DO). The degradation efficiency of APAP was studied under the optimal condition (initial pH 6.5, PS = 0.8 g L, Fe = 0.7 mM, CuO = 0.3 g L), and the results indicated that the Fe/CuO/PS system can achieve a higher degradation rate of APAP (92% within 90 min) rather than Fe/PS and CuO/PS system (79% and 10%). Quenching experiment was performed to verify the active radicals in the Fe/CuO/PS system. Sulfate and hydroxyl radicals were generated in the Fe/CuO/PS system. Besides, some critical factors, such as Fe concentration, catalyst dosage, PS concentration, initial pH (buffers and nonbuffers), and dissolved oxygen were evaluated in bath experiments. Results indicated that dissolved oxygen was essential in the Fe/CuO/PS system. APAP degradation experiments were conducted in surface water, and the intermediates were detected via GC-MS. The results indicated that the Fe/CuO/PS system is effective in the treatment of APAP in natural waters.
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December 2018

Flocculation of Microcystis aeruginosa using modified larch tannin.

Environ Sci Technol 2013 Jun 17;47(11):5771-7. Epub 2013 May 17.

College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China.

To flocculate the cyanobacterium Microcystis aeruginosa from water, larch tannin, a natural polymer, was modified by Mannich reaction to obtain a flocculant, named A-TN, which was then quaternized to yield another flocculant, named Q-TN. A-TN and Q-TN were characterized by Fourier transform infrared spectra (FTIR) and zeta potential analysis. The effects of the flocculation parameters, e.g., dosage, pH, cell density, culture time, and extracellular organic materials, were studied. The results showed that Q-TN was effective under a wider range of pH values than A-TN and could work under a pH of 9.0, whereas A-TN could work only under a pH of 7.0. For algal samples with densities from 1 × 10(8) to 5 × 10(9) cells/L, the optimum dosages of Q-TN to achieve more than 90% removal efficiency ranged from 0.5 to 20 mg/L, and the optimum dosages had a good linear relationship with cell density. Furthermore, the required dosage of Q-TN clearly increased along with the algae culture time, most of which was consumed by the extracellular organic materials (EOM) excreted from the cells. The spectra of the three-dimensional excitation-emission matrix showed that 100% of simple aromatic proteins and 78.8% of protein-like substances in the EOM could be removed by Q-TN. However, Q-TN was less effective in humic/fulvic-like substance flocculation. Q-TN functioned to settle the algae cells and a large amount of their metabolites effectively.
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June 2013

Specific expression of osteopontin and S100A6 in hepatocellular carcinoma.

Surgery 2011 Jun 18;149(6):783-91. Epub 2011 Feb 18.

Department of General Surgery, China-Japan Friendship Hospital, Beijing, P.R. China.

Background: Our aim was to identify differential expression of genes in hepatocellular carcinoma (HCC) with the ultimate goal of discovering novel diagnostic and therapeutic targets.

Methods: We examined differences in gene expression between HCC and noncancerous liver tissue using a cDNA array with probes for 15,843 genes/clones. Two genes, osteopontin (OPN) and S100A6, were found to be >10-fold differentially expressed, and were selected for further immunohistochemical staining in 51 HCC and 10 nonmalignant liver specimens. The relation between OPN and S100A6 alterations and various clinicopathologic parameters was also evaluated.

Results: We found a total of 219 genes that were differentially expressed >3-fold. Of these, 109 were upregulated and 110 downregulated. Within this group, 123 genes, including 59 upregulated and 64 downregulated, had been identified previously. These known genes were mainly involved in cell migration, cytoskeleton dynamics, the signaling pathway and cell cycle, and metabolism. OPN expression and S100A6 expression were seen in 26 of 51 (51.0 %) and 16 of 51 (31.4 %) HCC samples, respectively. More importantly, proteins coded by these genes were not found in any noncancerous liver specimen by immunohistochemical analysis. Expression of these genes correlated with poor differentiation (OPN: P = .013; S100A6: P = .008).

Conclusion: OPN, a secreted phosphoprotein that has been increasingly implicated in the progression and metastasis of cancer, and S100A6, a member of the S100 protein family that can perform cell proliferation, differentiation, migration, and cytoskeletal dynamics, may be promising diagnostic markers and therapeutic targets for HCC. In addition, the results encourage future studies involving the roles of these proteins in the development and progression of this cancer.
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June 2011

Analysis of serum cytokines in patients with severe acute respiratory syndrome.

Infect Immun 2004 Aug;72(8):4410-5

Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.

Severe acute respiratory syndrome (SARS) is an acute infectious disease of the respiratory system. Although a novel coronavirus has been identified as the causative agent of SARS, the pathogenic mechanisms of SARS are not understood. In this study, sera were collected from healthy donors, patients with SARS, patients with severe SARS, and patients with SARS in convalescence. The serum concentrations of interleukin-1 (IL-1), IL-4, IL-6, IL-8, IL-10, tumor growth factor beta (TGF-beta), tumor necrosis factor alpha (TNF-alpha), and gamma interferon (IFN-gamma) were measured by enzyme-linked immunosorbent assays (ELISA). The concentrations of IL-1 and TNF-alpha were not significantly different in different groups. The IL-6 concentration was increased in SARS patients and was significantly elevated in severe SARS patients, but the IL-6 concentrations were similar in convalescent patients and control subjects, suggesting that there was a positive relationship between the serum IL-6 concentration and SARS severity. The concentrations of IL-8 and TGF-beta were decreased in SARS patients and significantly reduced in severe SARS patients, but they were comparable in convalescent SARS patients and control subjects, suggesting that there was a negative relationship between the IL-8 and TGF-beta concentrations and SARS severity. The concentrations of IFN-gamma, IL-4, and IL-10 showed significant changes only in convalescent SARS patients. The IFN-gamma and IL-4 levels were decreased, while the levels of IL-10 were increased, and the differences between convalescent SARS patients and other patient groups were statistically significant. These results suggest that there are different immunoregulatory events during and after SARS and may contribute to our understanding of the pathogenesis of this syndrome.
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August 2004

Extra-stent vascular remodeling in in-stent restenosis after 188Re-MAG3 radiation therapy.

Int J Cardiol 2003 Dec;92(2-3):187-91

Department of Medicine, University of Ulsan College of Medicine, Cardiac Center, Asan Medical Center, 388-1 Poongnap-dong, Songpa-gu, 138-736, Seoul, South Korea

Background: The effect of beta-radiation on extra-stent vascular remodeling in patients with in-stent restenosis has not been studied. The correlation between the extent of extra-stent plaque proliferation and that of intimal hyperplasia (IH) in in-stent restenosis in patients who received beta-radiation therapy as well as conventional therapy has also not been studied.

Methods: We evaluated the extra-stent remodeling in diffuse in-stent restenosis between a beta-radiation therapy patient group (188Re-MAG3, n=50) and a control group (n=9) by applying serial intravascular ultrasound (IVUS) analysis. Matching (post-intervention and follow-up) images were acquired at the follow-up lesion site and were available in 44 of 50 patients who received radiation therapy and in seven of nine control patients.

Results: There was a significant increase of the external elastic membrane (EEM) area in both groups: 16.4 +/- 3.3 mm2 post-intervention to 17.1 +/- 3.3 mm2 at follow-up, P=0.001 in the radiation therapy group, and 16.8 +/- 4.0 mm2 post-intervention to 17.4 +/- 4.1 mm2 at follow-up, P=0.008 in the control group. There were no statistically significant differences of the Delta EEM area between the two groups: 0.7 +/- 0.4 mm2 in the radiation therapy group vs. 0.6 +/- 0.4 mm2 in the control group, P=0.389. The Delta IH area correlated with the Delta EEM area in the control group (r=0.826, P=0.022), but not in the radiation therapy group (r=0.016, P=0.919).

Conclusions: The findings of this IVUS study were that positive remodeling (increased EEM area) occurred equally in both control and irradiated patients with in-stent restenosis. The extent of remodeling was directly in proportion to IH in the control group, but no such relationship existed in the irradiated patient group.
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December 2003