Yuan-Tsong Chen

Yuan-Tsong Chen

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Yuan-Tsong Chen

Yuan-Tsong Chen

Publications by authors named "Yuan-Tsong Chen"

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Interethnic analyses of blood pressure loci in populations of East Asian and European descent.

Nat Commun 2018 11 28;9(1):5052. Epub 2018 Nov 28.

Medical Genomics Center, National Center for Global Health and Medicine, Tokyo, 162-8655, Japan.

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http://dx.doi.org/10.1038/s41467-018-07345-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261994PMC
November 2018

Loss of GPNMB Causes Autosomal-Recessive Amyloidosis Cutis Dyschromica in Humans.

Am J Hum Genet 2018 02 11;102(2):219-232. Epub 2018 Jan 11.

Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985536PMC
February 2018

Identification of functional single nucleotide polymorphisms in the branchpoint site.

Hum Genomics 2017 Nov 9;11(1):27. Epub 2017 Nov 9.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1186/s40246-017-0122-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5680774PMC
November 2017

Filamin B Loss-of-Function Mutation in Dimerization Domain Causes Autosomal-Recessive Spondylocarpotarsal Synostosis Syndrome with Rib Anomalies.

Hum Mutat 2017 05 27;38(5):540-547. Epub 2017 Feb 27.

Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1002/humu.23186DOI Listing
May 2017

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.

Authors:
Cassandra N Spracklen Peng Chen Young Jin Kim Xu Wang Hui Cai Shengxu Li Jirong Long Ying Wu Ya Xing Wang Fumihiko Takeuchi Jer-Yuarn Wu Keum-Ji Jung Cheng Hu Koichi Akiyama Yonghong Zhang Sanghoon Moon Todd A Johnson Huaixing Li Rajkumar Dorajoo Meian He Maren E Cannon Tamara S Roman Elias Salfati Keng-Hung Lin Xiuqing Guo Wayne H H Sheu Devin Absher Linda S Adair Themistocles L Assimes Tin Aung Qiuyin Cai Li-Ching Chang Chien-Hsiun Chen Li-Hsin Chien Lee-Ming Chuang Shu-Chun Chuang Shufa Du Qiao Fan Cathy S J Fann Alan B Feranil Yechiel Friedlander Penny Gordon-Larsen Dongfeng Gu Lixuan Gui Zhirong Guo Chew-Kiat Heng James Hixson Xuhong Hou Chao Agnes Hsiung Yao Hu Mi Yeong Hwang Chii-Min Hwu Masato Isono Jyh-Ming Jimmy Juang Chiea-Chuen Khor Yun Kyoung Kim Woon-Puay Koh Michiaki Kubo I-Te Lee Sun-Ju Lee Wen-Jane Lee Kae-Woei Liang Blanche Lim Sing-Hui Lim Jianjun Liu Toru Nabika Wen-Harn Pan Hao Peng Thomas Quertermous Charumathi Sabanayagam Kevin Sandow Jinxiu Shi Liang Sun Pok Chien Tan Shu-Pei Tan Kent D Taylor Yik-Ying Teo Sue-Anne Toh Tatsuhiko Tsunoda Rob M van Dam Aili Wang Feijie Wang Jie Wang Wen Bin Wei Yong-Bing Xiang Jie Yao Jian-Min Yuan Rong Zhang Wanting Zhao Yii-Der Ida Chen Stephen S Rich Jerome I Rotter Tzung-Dau Wang Tangchun Wu Xu Lin Bok-Ghee Han Toshihiro Tanaka Yoon Shin Cho Tomohiro Katsuya Weiping Jia Sun-Ha Jee Yuan-Tsong Chen Norihiro Kato Jost B Jonas Ching-Yu Cheng Xiao-Ou Shu Jiang He Wei Zheng Tien-Yin Wong Wei Huang Bong-Jo Kim E-Shyong Tai Karen L Mohlke Xueling Sim

Hum Mol Genet 2017 05;26(9):1770-1784

Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1093/hmg/ddx062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6075203PMC
May 2017

Genetic epidemiological study doesn't support GLA IVS4+919G>A variant is a significant mutation in Fabry disease.

Mol Genet Metab 2017 05 24;121(1):22-27. Epub 2017 Mar 24.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2017.03.005DOI Listing
May 2017

Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis.

J Invest Dermatol 2017 04 23;137(4):894-904. Epub 2016 Dec 23.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Taiwan Mouse Clinic, Academia Sinica, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2016.12.011DOI Listing
April 2017

Knock-in human FGFR3 achondroplasia mutation as a mouse model for human skeletal dysplasia.

Sci Rep 2017 02 23;7:43220. Epub 2017 Feb 23.

Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.

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http://dx.doi.org/10.1038/srep43220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322349PMC
February 2017

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

Authors:
Frank J A van Rooij Rehan Qayyum Albert V Smith Yi Zhou Stella Trompet Toshiko Tanaka Margaux F Keller Li-Ching Chang Helena Schmidt Min-Lee Yang Ming-Huei Chen James Hayes Andrew D Johnson Lisa R Yanek Christian Mueller Leslie Lange James S Floyd Mohsen Ghanbari Alan B Zonderman J Wouter Jukema Albert Hofman Cornelia M van Duijn Karl C Desch Yasaman Saba Ayse B Ozel Beverly M Snively Jer-Yuarn Wu Reinhold Schmidt Myriam Fornage Robert J Klein Caroline S Fox Koichi Matsuda Naoyuki Kamatani Philipp S Wild David J Stott Ian Ford P Eline Slagboom Jaden Yang Audrey Y Chu Amy J Lambert André G Uitterlinden Oscar H Franco Edith Hofer David Ginsburg Bella Hu Brendan Keating Ursula M Schick Jennifer A Brody Jun Z Li Zhao Chen Tanja Zeller Jack M Guralnik Daniel I Chasman Luanne L Peters Michiaki Kubo Diane M Becker Jin Li Gudny Eiriksdottir Jerome I Rotter Daniel Levy Vera Grossmann Kushang V Patel Chien-Hsiun Chen Paul M Ridker Hua Tang Lenore J Launer Kenneth M Rice Ruifang Li-Gao Luigi Ferrucci Michelle K Evans Avik Choudhuri Eirini Trompouki Brian J Abraham Song Yang Atsushi Takahashi Yoichiro Kamatani Charles Kooperberg Tamara B Harris Sun Ha Jee Josef Coresh Fuu-Jen Tsai Dan L Longo Yuan-Tsong Chen Janine F Felix Qiong Yang Bruce M Psaty Eric Boerwinkle Lewis C Becker Dennis O Mook-Kanamori James G Wilson Vilmundur Gudnason Christopher J O'Donnell Abbas Dehghan L Adrienne Cupples Michael A Nalls Andrew P Morris Yukinori Okada Alexander P Reiner Leonard I Zon Santhi K Ganesh

Am J Hum Genet 2017 Jan 22;100(1):51-63. Epub 2016 Dec 22.

Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

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http://www.cell.com/ajhg/pdf/S0002-9297(16)30520-1.pdf
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http://linkinghub.elsevier.com/retrieve/pii/S000292971630520
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http://dx.doi.org/10.1016/j.ajhg.2016.11.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5223059PMC
January 2017

Identification of susceptibility gene associated with female primary Sjögren's syndrome in Han Chinese by genome-wide association study.

Hum Genet 2016 Nov 8;135(11):1287-1294. Epub 2016 Aug 8.

National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, 128 Sec. 2, Academia Rd. Nankang, Taipei, 11529, Taiwan.

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http://dx.doi.org/10.1007/s00439-016-1716-0DOI Listing
November 2016

Measurement of Pre-Existing IgG and IgM Antibodies against Polyethylene Glycol in Healthy Individuals.

Anal Chem 2016 11 21;88(21):10661-10666. Epub 2016 Oct 21.

Institute of Biomedical Sciences, Academia Sinica , Taipei 11529, Taiwan.

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http://dx.doi.org/10.1021/acs.analchem.6b03109DOI Listing
November 2016

Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage.

AAPS J 2016 05 7;18(3):757-66. Epub 2016 Mar 7.

Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, 533 Parnassus Avenue, Room U-68, San Francisco, California, 94143-0912, USA.

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http://link.springer.com/10.1208/s12248-016-9898-x
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http://dx.doi.org/10.1208/s12248-016-9898-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5256615PMC
May 2016

Novel susceptibility gene for nonfamilial hypokalemic periodic paralysis.

Neurology 2016 Mar 2;86(13):1190-8. Epub 2016 Mar 2.

From the Institute of Biomedical Sciences (I.-W.S., C.-H.C., Y.-C.C., J.-H.Y., Y.-T.C., J.-Y.W.), Academia Sinica; Graduate Institute of Life Science (I.-W.S.), Division of Nephrology, Department of Medicine, Tri-Service General Hospital (C.-C.S., C.-J.C., S.-S.Y., S.-H.L.), and Graduate Institute of Medical Science (C.-C.S., S.-S.Y., S.-H.L.), National Defense Medical Center, Taipei, Taiwan; Department of Pediatrics (Y.-T.C.), Duke University Medical Center, Durham, NC; and Graduate Institute of Chinese Medical Science (J.-Y.W.), China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1212/WNL.0000000000002524DOI Listing
March 2016

Pharmacogenomics for personalized pain medicine.

Acta Anaesthesiol Taiwan 2016 Mar 11;54(1):24-30. Epub 2016 Mar 11.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.aat.2016.02.001DOI Listing
March 2016

An integrated analysis tool for analyzing hybridization intensities and genotypes using new-generation population-optimized human arrays.

BMC Genomics 2016 Mar 31;17:266. Epub 2016 Mar 31.

Bioinformatics Program, Taiwan International Graduate Program, Institute of Information Science, Academia Sinica, Taipei, 115, Taiwan.

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http://dx.doi.org/10.1186/s12864-016-2478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815280PMC
March 2016

Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation.

J Invest Dermatol 2015 Nov 29;135(11):2603-2610. Epub 2015 Jun 29.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.240DOI Listing
November 2015

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation.

Authors:
Norihiro Kato Marie Loh Fumihiko Takeuchi Niek Verweij Xu Wang Weihua Zhang Tanika N Kelly Danish Saleheen Benjamin Lehne Irene Mateo Leach Alexander W Drong James Abbott Simone Wahl Sian-Tsung Tan William R Scott Gianluca Campanella Marc Chadeau-Hyam Uzma Afzal Tarunveer S Ahluwalia Marc Jan Bonder Peng Chen Abbas Dehghan Todd L Edwards Tõnu Esko Min Jin Go Sarah E Harris Jaana Hartiala Silva Kasela Anuradhani Kasturiratne Chiea-Chuen Khor Marcus E Kleber Huaixing Li Zuan Yu Mok Masahiro Nakatochi Nur Sabrina Sapari Richa Saxena Alexandre F R Stewart Lisette Stolk Yasuharu Tabara Ai Ling Teh Ying Wu Jer-Yuarn Wu Yi Zhang Imke Aits Alexessander Da Silva Couto Alves Shikta Das Rajkumar Dorajoo Jemma C Hopewell Yun Kyoung Kim Robert W Koivula Jian'an Luan Leo-Pekka Lyytikäinen Quang N Nguyen Mark A Pereira Iris Postmus Olli T Raitakari Molly Scannell Bryan Robert A Scott Rossella Sorice Vinicius Tragante Michela Traglia Jon White Ken Yamamoto Yonghong Zhang Linda S Adair Alauddin Ahmed Koichi Akiyama Rasheed Asif Tin Aung Inês Barroso Andrew Bjonnes Timothy R Braun Hui Cai Li-Ching Chang Chien-Hsiun Chen Ching-Yu Cheng Yap-Seng Chong Rory Collins Regina Courtney Gail Davies Graciela Delgado Loi D Do Pieter A Doevendans Ron T Gansevoort Yu-Tang Gao Tanja B Grammer Niels Grarup Jagvir Grewal Dongfeng Gu Gurpreet S Wander Anna-Liisa Hartikainen Stanley L Hazen Jing He Chew-Kiat Heng James E Hixson Albert Hofman Chris Hsu Wei Huang Lise L N Husemoen Joo-Yeon Hwang Sahoko Ichihara Michiya Igase Masato Isono Johanne M Justesen Tomohiro Katsuya Muhammad G Kibriya Young Jin Kim Miyako Kishimoto Woon-Puay Koh Katsuhiko Kohara Meena Kumari Kenneth Kwek Nanette R Lee Jeannette Lee Jiemin Liao Wolfgang Lieb David C M Liewald Tatsuaki Matsubara Yumi Matsushita Thomas Meitinger Evelin Mihailov Lili Milani Rebecca Mills Nina Mononen Martina Müller-Nurasyid Toru Nabika Eitaro Nakashima Hong Kiat Ng Kjell Nikus Teresa Nutile Takayoshi Ohkubo Keizo Ohnaka Sarah Parish Lavinia Paternoster Hao Peng Annette Peters Son T Pham Mohitha J Pinidiyapathirage Mahfuzar Rahman Hiromi Rakugi Olov Rolandsson Michelle Ann Rozario Daniela Ruggiero Cinzia F Sala Ralhan Sarju Kazuro Shimokawa Harold Snieder Thomas Sparsø Wilko Spiering John M Starr David J Stott Daniel O Stram Takao Sugiyama Silke Szymczak W H Wilson Tang Lin Tong Stella Trompet Väinö Turjanmaa Hirotsugu Ueshima André G Uitterlinden Satoshi Umemura Marja Vaarasmaki Rob M van Dam Wiek H van Gilst Dirk J van Veldhuisen Jorma S Viikari Melanie Waldenberger Yiqin Wang Aili Wang Rory Wilson Tien-Yin Wong Yong-Bing Xiang Shuhei Yamaguchi Xingwang Ye Robin D Young Terri L Young Jian-Min Yuan Xueya Zhou Folkert W Asselbergs Marina Ciullo Robert Clarke Panos Deloukas Andre Franke Paul W Franks Steve Franks Yechiel Friedlander Myron D Gross Zhirong Guo Torben Hansen Marjo-Riitta Jarvelin Torben Jørgensen J Wouter Jukema Mika Kähönen Hiroshi Kajio Mika Kivimaki Jong-Young Lee Terho Lehtimäki Allan Linneberg Tetsuro Miki Oluf Pedersen Nilesh J Samani Thorkild I A Sørensen Ryoichi Takayanagi Daniela Toniolo Habibul Ahsan Hooman Allayee Yuan-Tsong Chen John Danesh Ian J Deary Oscar H Franco Lude Franke Bastiaan T Heijman Joanna D Holbrook Aaron Isaacs Bong-Jo Kim Xu Lin Jianjun Liu Winfried März Andres Metspalu Karen L Mohlke Dharambir K Sanghera Xiao-Ou Shu Joyce B J van Meurs Eranga Vithana Ananda R Wickremasinghe Cisca Wijmenga Bruce H W Wolffenbuttel Mitsuhiro Yokota Wei Zheng Dingliang Zhu Paolo Vineis Soterios A Kyrtopoulos Jos C S Kleinjans Mark I McCarthy Richie Soong Christian Gieger James Scott Yik-Ying Teo Jiang He Paul Elliott E Shyong Tai Pim van der Harst Jaspal S Kooner John C Chambers

Nat Genet 2015 11 21;47(11):1282-1293. Epub 2015 Sep 21.

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.

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http://dx.doi.org/10.1038/ng.3405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719169PMC
November 2015

Genetic determinants of antithyroid drug-induced agranulocytosis by human leukocyte antigen genotyping and genome-wide association study.

Nat Commun 2015 Jul 7;6:7633. Epub 2015 Jul 7.

1] Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan. [2] Department of Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan.

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http://dx.doi.org/10.1038/ncomms8633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506516PMC
July 2015

Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction.

J Allergy Clin Immunol 2015 Apr 11;135(4):1063-5.e5. Epub 2014 Nov 11.

Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2014.09.041DOI Listing
April 2015

Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence.

Sci Rep 2015 Apr 24;5:9633. Epub 2015 Apr 24.

1] Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, ROC [2] Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1038/srep09633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5386118PMC
April 2015

Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension.

Hypertens Res 2015 Feb 20;38(2):155-62. Epub 2014 Nov 20.

1] Institute of Clinical Medicine and Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan [2] Divison of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan [3] Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.

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http://dx.doi.org/10.1038/hr.2014.152DOI Listing
February 2015

CXCL10/IP-10 is a biomarker and mediator for Kawasaki disease.

Circ Res 2015 Feb 20;116(5):876-83. Epub 2015 Jan 20.

From the Institute of Biomedical Sciences (T.-M.K., S.-P.C., Y.-M.L., H.-W.C., C.-H.C., J.-Y.W., Y.-T.C.) and Institute of Cellular and Organismic Biology (Y.-C.L.), Academia Sinica, Taipei, Taiwan; Department of Pediatrics and Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan (H.-C.K.); Chang Gung University College of Medicine, Taoyuan, Taiwan (H.-C.K.); Department of Pediatric Cardiology, Children's Hospital of China Medical University, Taichung, Taiwan (J.-S.C.); School of Medicine (J.-S.C.), School of Chinese Medicine (F.-J.T.), and Department of Medical Genetics (F.-J.T., C.-H.C., J.-Y.W.), China Medical University Hospital, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan (F.-J.T.); and Department of Pediatrics, Duke University Medical Center, Durham, NC (Y.-T.C.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.305834DOI Listing
February 2015

Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model.

PLoS One 2014 17;9(3):e92194. Epub 2014 Mar 17.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0092194PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956893PMC
November 2014

Mouse model of glycogen storage disease type III.

Mol Genet Metab 2014 Apr 18;111(4):467-76. Epub 2014 Feb 18.

Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan; Department of Pediatrics, Duke University Medical Center, Box 3528, Durham, NC 27710, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192140006
Publisher Site
http://dx.doi.org/10.1016/j.ymgme.2014.02.005DOI Listing
April 2014

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Authors:
Anubha Mahajan Min Jin Go Weihua Zhang Jennifer E Below Kyle J Gaulton Teresa Ferreira Momoko Horikoshi Andrew D Johnson Maggie C Y Ng Inga Prokopenko Danish Saleheen Xu Wang Eleftheria Zeggini Goncalo R Abecasis Linda S Adair Peter Almgren Mustafa Atalay Tin Aung Damiano Baldassarre Beverley Balkau Yuqian Bao Anthony H Barnett Ines Barroso Abdul Basit Latonya F Been John Beilby Graeme I Bell Rafn Benediktsson Richard N Bergman Bernhard O Boehm Eric Boerwinkle Lori L Bonnycastle Noël Burtt Qiuyin Cai Harry Campbell Jason Carey Stephane Cauchi Mark Caulfield Juliana C N Chan Li-Ching Chang Tien-Jyun Chang Yi-Cheng Chang Guillaume Charpentier Chien-Hsiun Chen Han Chen Yuan-Tsong Chen Kee-Seng Chia Manickam Chidambaram Peter S Chines Nam H Cho Young Min Cho Lee-Ming Chuang Francis S Collins Marylin C Cornelis David J Couper Andrew T Crenshaw Rob M van Dam John Danesh Debashish Das Ulf de Faire George Dedoussis Panos Deloukas Antigone S Dimas Christian Dina Alex S Doney Peter J Donnelly Mozhgan Dorkhan Cornelia van Duijn Josée Dupuis Sarah Edkins Paul Elliott Valur Emilsson Raimund Erbel Johan G Eriksson Jorge Escobedo Tonu Esko Elodie Eury Jose C Florez Pierre Fontanillas Nita G Forouhi Tom Forsen Caroline Fox Ross M Fraser Timothy M Frayling Philippe Froguel Philippe Frossard Yutang Gao Karl Gertow Christian Gieger Bruna Gigante Harald Grallert George B Grant Leif C Grrop Chrisropher J Groves Elin Grundberg Candace Guiducci Anders Hamsten Bok-Ghee Han Kazuo Hara Neelam Hassanali Andrew T Hattersley Caroline Hayward Asa K Hedman Christian Herder Albert Hofman Oddgeir L Holmen Kees Hovingh Astradur B Hreidarsson Cheng Hu Frank B Hu Jennie Hui Steve E Humphries Sarah E Hunt David J Hunter Kristian Hveem Zafar I Hydrie Hiroshi Ikegami Thomas Illig Erik Ingelsson Muhammed Islam Bo Isomaa Anne U Jackson Tazeen Jafar Alan James Weiping Jia Karl-Heinz Jöckel Anna Jonsson Jeremy B M Jowett Takashi Kadowaki Hyun Min Kang Stavroula Kanoni Wen Hong L Kao Sekar Kathiresan Norihiro Kato Prasad Katulanda Kirkka M Keinanen-Kiukaanniemi Ann M Kelly Hassan Khan Kay-Tee Khaw Chiea-Chuen Khor Hyung-Lae Kim Sangsoo Kim Young Jin Kim Leena Kinnunen Norman Klopp Augustine Kong Eeva Korpi-Hyövälti Sudhir Kowlessur Peter Kraft Jasmina Kravic Malene M Kristensen S Krithika Ashish Kumar Jesus Kumate Johanna Kuusisto Soo Heon Kwak Markku Laakso Vasiliki Lagou Timo A Lakka Claudia Langenberg Cordelia Langford Robert Lawrence Karin Leander Jen-Mai Lee Nanette R Lee Man Li Xinzhong Li Yun Li Junbin Liang Samuel Liju Wei-Yen Lim Lars Lind Cecilia M Lindgren Eero Lindholm Ching-Ti Liu Jian Jun Liu Stéphane Lobbens Jirong Long Ruth J F Loos Wei Lu Jian'an Luan Valeriya Lyssenko Ronald C W Ma Shiro Maeda Reedik Mägi Satu Männisto David R Matthews James B Meigs Olle Melander Andres Metspalu Julia Meyer Ghazala Mirza Evelin Mihailov Susanne Moebus Viswanathan Mohan Karen L Mohlke Andrew D Morris Thomas W Mühleisen Martina Müller-Nurasyid Bill Musk Jiro Nakamura Eitaro Nakashima Pau Navarro Peng-Keat Ng Alexandra C Nica Peter M Nilsson Inger Njølstad Markus M Nöthen Keizo Ohnaka Twee Hee Ong Katharine R Owen Colin N A Palmer James S Pankow Kyong Soo Park Melissa Parkin Sonali Pechlivanis Nancy L Pedersen Leena Peltonen John R B Perry Annette Peters Janini M Pinidiyapathirage Carl G Platou Simon Potter Jackie F Price Lu Qi Venkatesan Radha Loukianos Rallidis Asif Rasheed Wolfgang Rathman Rainer Rauramaa Soumya Raychaudhuri N William Rayner Simon D Rees Emil Rehnberg Samuli Ripatti Neil Robertson Michael Roden Elizabeth J Rossin Igor Rudan Denis Rybin Timo E Saaristo Veikko Salomaa Juha Saltevo Maria Samuel Dharambir K Sanghera Jouko Saramies James Scott Laura J Scott Robert A Scott Ayellet V Segrè Joban Sehmi Bengt Sennblad Nabi Shah Sonia Shah A Samad Shera Xiao Ou Shu Alan R Shuldiner Gunnar Sigurđsson Eric Sijbrands Angela Silveira Xueling Sim Suthesh Sivapalaratnam Kerrin S Small Wing Yee So Alena Stančáková Kari Stefansson Gerald Steinbach Valgerdur Steinthorsdottir Kathleen Stirrups Rona J Strawbridge Heather M Stringham Qi Sun Chen Suo Ann-Christine Syvänen Ryoichi Takayanagi Fumihiko Takeuchi Wan Ting Tay Tanya M Teslovich Barbara Thorand Gudmar Thorleifsson Unnur Thorsteinsdottir Emmi Tikkanen Joseph Trakalo Elena Tremoli Mieke D Trip Fuu Jen Tsai Tiinamaija Tuomi Jaakko Tuomilehto Andre G Uitterlinden Adan Valladares-Salgado Sailaja Vedantam Fabrizio Veglia Benjamin F Voight Congrong Wang Nicholas J Wareham Roman Wennauer Ananda R Wickremasinghe Tom Wilsgaard James F Wilson Steven Wiltshire Wendy Winckler Tien Yin Wong Andrew R Wood Jer-Yuarn Wu Ying Wu Ken Yamamoto Toshimasa Yamauchi Mingyu Yang Loic Yengo Mitsuhiro Yokota Robin Young Delilah Zabaneh Fan Zhang Rong Zhang Wei Zheng Paul Z Zimmet David Altshuler Donald W Bowden Yoon Shin Cho Nancy J Cox Miguel Cruz Craig L Hanis Jaspal Kooner Jong-Young Lee Mark Seielstad Yik Ying Teo Michael Boehnke Esteban J Parra Jonh C Chambers E Shyong Tai Mark I McCarthy Andrew P Morris

Nat Genet 2014 Mar 9;46(3):234-44. Epub 2014 Feb 9.

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http://dx.doi.org/10.1038/ng.2897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969612PMC
March 2014

De novo MECP2 duplication derived from paternal germ line result in dysmorphism and developmental delay.

Gene 2014 Jan 12;533(1):78-85. Epub 2013 Oct 12.

Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan; Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.gene.2013.10.001DOI Listing
January 2014

A new nucleic acid-based agent inhibits cytotoxic T lymphocyte-mediated immune disorders.

J Allergy Clin Immunol 2013 Sep 19;132(3):713-722.e11. Epub 2013 Jun 19.

Department and Institute of Pharmacology, School of Medicine, Infection and Immunity Research Center, National Yang-Ming University, Taipei, Taiwan; Molecular Medicine Program, National Yang-Ming University and Academia Sinica, Taipei, Taiwan. Electronic address:

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September 2013

Alglucosidase alfa enzyme replacement therapy as a therapeutic approach for glycogen storage disease type III.

Mol Genet Metab 2013 Feb 27;108(2):145-7. Epub 2012 Dec 27.

Division of Medical Genetics, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1016/j.ymgme.2012.12.002DOI Listing
February 2013

Pharmacogenomics of adverse drug reactions: implementing personalized medicine.

Hum Mol Genet 2012 Oct 19;21(R1):R58-65. Epub 2012 Aug 19.

Institute of Biomedical Sciences, Academia Sinica, Taipei 115, Taiwan.

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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/dds341
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October 2012

A recent update of pharmacogenomics in drug-induced severe skin reactions.

Drug Metab Pharmacokinet 2012 1;27(1):132-41. Epub 2011 Nov 1.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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July 2012

VarioWatch: providing large-scale and comprehensive annotations on human genomic variants in the next generation sequencing era.

Nucleic Acids Res 2012 Jul 22;40(Web Server issue):W76-81. Epub 2012 May 22.

National Center for Genome Medicine and Institute of Biomedical Sciences, Academia Sinica, Taiwan 11529, R.O.C.

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http://dx.doi.org/10.1093/nar/gks397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3394242PMC
July 2012

T-cell receptor and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: understanding a hypersensitivity reaction.

Expert Rev Clin Immunol 2012 Jul;8(5):467-77

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

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July 2012

Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome.

J Allergy Clin Immunol 2012 Jun 8;129(6):1562-9.e5. Epub 2012 Feb 8.

Molecular Medicine Program, Taiwan International Graduate Program, Taipei, Taiwan.

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http://dx.doi.org/10.1016/j.jaci.2011.12.990DOI Listing
June 2012

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome.

J Allergy Clin Immunol 2011 Dec 14;128(6):1266-1276.e11. Epub 2011 Sep 14.

Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan.

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December 2011

Molecular profile and copy number analysis of sporadic colorectal cancer in Taiwan.

J Biomed Sci 2011 Jun 7;18:36. Epub 2011 Jun 7.

Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3123622PMC
June 2011

SAQC: SNP array quality control.

BMC Bioinformatics 2011 Apr 18;12:100. Epub 2011 Apr 18.

Institute of Statistical Science, Academia Sinica, Taipei, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101186PMC
April 2011

Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV.

Hum Mol Genet 2011 Feb 12;20(3):455-65. Epub 2010 Nov 12.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

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February 2011

Mitochondrial GLUT10 facilitates dehydroascorbic acid import and protects cells against oxidative stress: mechanistic insight into arterial tortuosity syndrome.

Hum Mol Genet 2010 Oct 16;19(19):3721-33. Epub 2010 Jul 16.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, Republic of China.

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http://dx.doi.org/10.1093/hmg/ddq286DOI Listing
October 2010

Pharmacogenetics of toxic epidermal necrolysis.

Expert Opin Pharmacother 2010 Sep;11(13):2153-62

Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, Nankang, 11529 Taipei, Taiwan.

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http://dx.doi.org/10.1517/14656566.2010.495120DOI Listing
September 2010

Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese.

Pharmacogenomics 2010 Mar;11(3):349-56

Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2, Nankang, Taipei 11529, Taiwan.

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http://dx.doi.org/10.2217/pgs.09.162DOI Listing
March 2010

Genetic predisposition of life-threatening antiepileptic-induced skin reactions.

Expert Opin Drug Saf 2010 Jan;9(1):15-21

Chang Gung University College of Medicine, Chang Gung Memorial Hospital, Department of Dermatology, Tung-Hwa North Road, Taipei 10507, Taiwan.

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http://dx.doi.org/10.1517/14740330903427969DOI Listing
January 2010

Chromosomal and genetic alterations in human hepatocellular adenomas associated with type Ia glycogen storage disease.

Hum Mol Genet 2009 Dec 16;18(24):4781-90. Epub 2009 Sep 16.

Division of Medical Genetics, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1093/hmg/ddp441DOI Listing
December 2009

Pompe disease in infants: improving the prognosis by newborn screening and early treatment.

Pediatrics 2009 Dec;124(6):e1116-25

Department of Pediatrics and Medical Genetics, National Taiwan University Hospital, Taipei 10041, Taiwan.

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http://dx.doi.org/10.1542/peds.2008-3667DOI Listing
December 2009

Genetic determinants of warfarin dosing in the Han-Chinese population.

Pharmacogenomics 2009 Dec;10(12):1905-13

Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2, NanKang, Taipei, Taiwan.

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http://dx.doi.org/10.2217/pgs.09.106DOI Listing
December 2009

Mapping human genetic diversity in Asia.

Science 2009 Dec;326(5959):1541-5

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http://dx.doi.org/10.1126/science.1177074DOI Listing
December 2009

A genome-wide survey of copy number variations in Han Chinese residing in Taiwan.

Genomics 2009 Oct 25;94(4):241-6. Epub 2009 Jun 25.

Institute of Biomedical Sciences, Academia Sinica, 128, Academia Road, Section 2 Nankang, Taipei 115, Taiwan.

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http://dx.doi.org/10.1016/j.ygeno.2009.06.004DOI Listing
October 2009

VKORC1 haplotypes in five East-Asian populations and Indians.

Pharmacogenomics 2009 Oct;10(10):1609-16

Institute of Biomedical Sciences, Academia Sinica, 128 Academia Road, Section 2, NanKang, Taipei, Taiwan.

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http://dx.doi.org/10.2217/pgs.09.80DOI Listing
October 2009

Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.

Pharmacogenomics 2009 Mar;10(3):359-74

Institute of Biomedical Sciences, Academia Sinica, No 128, Sec. 2, Academia Road, Nankang, Taipei 11529, Taiwan.

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March 2009