Yuan-Fang Wang

Yuan-Fang Wang

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Yuan-Fang Wang

Yuan-Fang Wang

Publications by authors named "Yuan-Fang Wang"

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70Publications

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Vision-Language Navigation Policy Learning and Adaptation.

IEEE Trans Pattern Anal Mach Intell 2020 Feb 7. Epub 2020 Feb 7.

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http://dx.doi.org/10.1109/TPAMI.2020.2972281DOI Listing
February 2020

Structural studies of antiviral inhibitor with HIV-1 protease bearing drug resistant substitutions of V32I, I47V and V82I.

Biochem Biophys Res Commun 2019 Jun 12;514(3):974-978. Epub 2019 May 12.

Department of Biology, Georgia State University, Atlanta, GA, 30303, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2019.05.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601333PMC
June 2019

Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues.

ACS Omega 2019 May 17;4(5):8707-8719. Epub 2019 May 17.

Department of Biology, Georgia State University, P.O. Box 4010, Atlanta, Georgia 30302, United States.

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http://dx.doi.org/10.1021/acsomega.9b00683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545544PMC
May 2019

Design, synthesis, and X-ray studies of potent HIV-1 protease inhibitors incorporating aminothiochromane and aminotetrahydronaphthalene carboxamide derivatives as the P2 ligands.

Eur J Med Chem 2018 Dec 18;160:171-182. Epub 2018 Sep 18.

Department of Refractory Viral Infections, National Center for Global Health & Medicine Research Institute, Tokyo, 162-8655, Japan; Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto, 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S02235234183081
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http://dx.doi.org/10.1016/j.ejmech.2018.09.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237192PMC
December 2018

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.

ACS Omega 2018 Sep 27;3(9):12132-12140. Epub 2018 Sep 27.

Department of Biology, Molecular Basis of Disease Program, Department of Computer Science, and Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, United States.

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http://dx.doi.org/10.1021/acsomega.8b01683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167001PMC
September 2018

Crystal structure of yeast nitronate monooxygenase from Cyberlindnera saturnus.

Proteins 2018 05 6;86(5):599-605. Epub 2018 Feb 6.

Department of Biology, Georgia State University, Atlanta, Georgia, 30302-3965.

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http://dx.doi.org/10.1002/prot.25470DOI Listing
May 2018

[Effects of Tongbi capsule on joint lesions in rabbits with rheumatoid arthritis].

Zhongguo Zhong Yao Za Zhi 2018 Mar;43(5):1034-1041

Bohai Yantai Pharmaceutical Group Co., Ltd., Yantai 264003, China.

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180104.004DOI Listing
March 2018

Design, Synthesis, Biological Evaluation, and X-ray Studies of HIV-1 Protease Inhibitors with Modified P2' Ligands of Darunavir.

ChemMedChem 2017 12 24;12(23):1942-1952. Epub 2017 Nov 24.

Departments of Hematology and Infectious Diseases, Kumamoto University School of Medicine, Kumamoto, 860-8556, Japan.

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http://dx.doi.org/10.1002/cmdc.201700614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896574PMC
December 2017

Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.

Bioorg Med Chem Lett 2017 11 6;27(21):4925-4931. Epub 2017 Sep 6.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2017.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647257PMC
November 2017

Design of novel HIV-1 protease inhibitors incorporating isophthalamide-derived P2-P3 ligands: Synthesis, biological evaluation and X-ray structural studies of inhibitor-HIV-1 protease complex.

Bioorg Med Chem 2017 10 9;25(19):5114-5127. Epub 2017 Apr 9.

Department of Hematology, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Department of Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch National Cancer Institute, Bethesda, MD 20892, USA; Department of Refractory Viral Infection, National Center for Global Health and Medicine Research Institute, Shinjuku, Tokyo 162-8655, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173073
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http://dx.doi.org/10.1016/j.bmc.2017.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617771PMC
October 2017

Paraventricular nucleus is involved in the central pathway of adipose afferent reflex in rats.

Can J Physiol Pharmacol 2016 May 28;94(5):534-41. Epub 2015 Oct 28.

a Department of Physiology, Binzhou Medical University, 346 Guanhai Rd., Laishan District, Yantai 264003, China.

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http://dx.doi.org/10.1139/cjpp-2015-0097DOI Listing
May 2016

New sesquiterpenes from the rhizomes of homalomena occulta.

Fitoterapia 2016 Mar 21;109:113-8. Epub 2015 Dec 21.

The Key Laboratory of Traditional Chinese Medicine Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine, School of Pharmacy, Binzhou Medical University, Guanai Road 346, Yantai 264003, China. Electronic address:

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http://dx.doi.org/10.1016/j.fitote.2015.12.015DOI Listing
March 2016

Structure-based design, synthesis, X-ray studies, and biological evaluation of novel HIV-1 protease inhibitors containing isophthalamide-derived P2-ligands.

Bioorg Med Chem Lett 2015 Nov 30;25(21):4903-4909. Epub 2015 May 30.

Departments of Hematology and Infectious Diseases, Kumamoto University of Medicine, Kumamoto 860-8556, Japan; Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892, USA; Center for Clinical Sciences, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2015.05.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607586PMC
November 2015

[Pathogen Characteristics of Catheter-related Bloodstream Infection].

Sichuan Da Xue Xue Bao Yi Xue Ban 2015 Sep;46(5):794-7

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September 2015

Structure-based design of potent HIV-1 protease inhibitors with modified P1-biphenyl ligands: synthesis, biological evaluation, and enzyme-inhibitor X-ray structural studies.

J Med Chem 2015 Jul 24;58(13):5334-43. Epub 2015 Jun 24.

§Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Medical and Pharmaceutical Sciences, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765733PMC
July 2015

[Anthraquinones and triterpenoids from roots of Knoxia roxburghii].

Zhongguo Zhong Yao Za Zhi 2014 Nov;39(21):4230-3

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November 2014

[Experimental study on anti-pancreatic cancer effect of oridonin].

Zhong Yao Cai 2014 Jul;37(7):1230-3

Guangdong Province Key Laboratory of Biotechnology Drug Candidate, Guangdong Pharmaceutical University, China.

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July 2014

Structures of darunavir-resistant HIV-1 protease mutant reveal atypical binding of darunavir to wide open flaps.

ACS Chem Biol 2014 Jun 28;9(6):1351-8. Epub 2014 Apr 28.

Department of Chemistry, ‡Department of Biology, and §Department of Computer Science, Georgia State University , Atlanta, Georgia 30303, United States.

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http://dx.doi.org/10.1021/cb4008875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076034PMC
June 2014

Structure of choline oxidase in complex with the reaction product glycine betaine.

Acta Crystallogr D Biol Crystallogr 2014 Feb 29;70(Pt 2):405-13. Epub 2014 Jan 29.

Department of Chemistry, Georgia State University, PO Box 3965, Atlanta, GA 30302-3965, USA.

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http://dx.doi.org/10.1107/S1399004713029283DOI Listing
February 2014

Structural basis for a hand-like site in the calcium sensor CatchER with fast kinetics.

Acta Crystallogr D Biol Crystallogr 2013 Dec 19;69(Pt 12):2309-19. Epub 2013 Nov 19.

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1107/S0907444913021306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852649PMC
December 2013

Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.

J Med Chem 2013 Sep 15;56(17):6792-802. Epub 2013 Aug 15.

Department of Chemistry and Department of Medicinal Chemistry, Purdue University , West Lafayette, Indiana 47907, United States.

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http://dx.doi.org/10.1021/jm400768fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800042PMC
September 2013

[Effect of panax notoginseng powder on pathological features and expressions of VEGF and its receptors of chronic subdural hematoma rabbits: an experimental study].

Zhongguo Zhong Xi Yi Jie He Za Zhi 2013 Jul;33(7):938-43

Department of Neurosurgery, Yantaishan Hospital, Shandong 264001, China.

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July 2013

Capturing the reaction pathway in near-atomic-resolution crystal structures of HIV-1 protease.

Biochemistry 2012 Oct 21;51(39):7726-32. Epub 2012 Sep 21.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, Georgia 30303, United States.

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http://pubs.acs.org/doi/10.1021/bi3008092
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http://dx.doi.org/10.1021/bi3008092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3476052PMC
October 2012

Removal of acid and direct dye by epichlorohydrin-dimethylamine: flocculation performance and floc aggregation properties.

Bioresour Technol 2012 Jun 11;113:265-71. Epub 2011 Dec 11.

Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, No. 27 Shanda South Road, 250100 Jinan, China.

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http://dx.doi.org/10.1016/j.biortech.2011.11.106DOI Listing
June 2012

Potent antiviral HIV-1 protease inhibitor GRL-02031 adapts to the structures of drug resistant mutants with its P1'-pyrrolidinone ring.

J Med Chem 2012 Apr 22;55(7):3387-97. Epub 2012 Mar 22.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, P.O. Box 4010, Atlanta, Georgia 30302-4010, USA.

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http://dx.doi.org/10.1021/jm300072dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355519PMC
April 2012

Critical differences in HIV-1 and HIV-2 protease specificity for clinical inhibitors.

Protein Sci 2012 Mar 24;21(3):339-50. Epub 2012 Jan 24.

Department of Biology, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1002/pro.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375435PMC
March 2012

The L76V drug resistance mutation decreases the dimer stability and rate of autoprocessing of HIV-1 protease by reducing internal hydrophobic contacts.

Biochemistry 2011 May 3;50(21):4786-95. Epub 2011 May 3.

Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1021/bi200033zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101314PMC
May 2011

Structural and kinetic studies on the Ser101Ala variant of choline oxidase: catalysis by compromise.

Arch Biochem Biophys 2010 Sep 16;501(2):207-13. Epub 2010 Jun 16.

Department of Chemistry, Georgia State University, Atlanta, GA 30302-4098, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000398611000233
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http://dx.doi.org/10.1016/j.abb.2010.06.014DOI Listing
September 2010

Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters.

FEBS J 2010 Sep 2;277(18):3699-714. Epub 2010 Aug 2.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2010.07771.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975871PMC
September 2010

Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.

J Med Chem 2007 Sep 16;50(18):4509-15. Epub 2007 Aug 16.

Department of Biology, Molecular Basis of Disease, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1021/jm070482qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751596PMC
September 2007

A novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI), GRL-98065, is potent against multiple-PI-resistant human immunodeficiency virus in vitro.

Antimicrob Agents Chemother 2007 Jun 19;51(6):2143-55. Epub 2007 Mar 19.

Departments of Infectious Diseases and Hematology, Kumamoto University School of Medicine, 1-1-1 Honjo, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1128/AAC.01413-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1891396PMC
June 2007

Atomic resolution crystal structures of HIV-1 protease and mutants V82A and I84V with saquinavir.

Proteins 2007 Apr;67(1):232-42

Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.

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http://dx.doi.org/10.1002/prot.21304DOI Listing
April 2007

Efficient molecular surface generation using level-set methods.

J Mol Graph Model 2006 Dec 18;25(4):442-54. Epub 2006 Apr 18.

Department of Computer Engineering, Middle East Technical University, 06531 Ankara, Turkey.

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http://linkinghub.elsevier.com/retrieve/pii/S109332630600060
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http://dx.doi.org/10.1016/j.jmgm.2006.02.012DOI Listing
December 2006

CTSS: a robust and efficient method for protein structure alignment based on local geometrical and biological features.

Proc IEEE Comput Soc Bioinform Conf 2003 ;2:169-79

Department of Computer Science, University of California at Santa Barbara, 93106, USA.

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August 2006

Automated protein classification using consensus decision.

Proc IEEE Comput Syst Bioinform Conf 2004 :224-35

Department of Computer Science, University of California at Santa Barbara, 93106, USA.

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http://dx.doi.org/10.1109/csb.2004.1332436DOI Listing
July 2006

Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.

J Mol Biol 2006 May 20;358(5):1191-9. Epub 2006 Mar 20.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2006.02.076DOI Listing
May 2006

Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.

J Mol Biol 2005 Dec 21;354(4):789-800. Epub 2005 Oct 21.

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.09.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1403828PMC
December 2005

Decision tree based information integration for automated protein classification.

J Bioinform Comput Biol 2005 Jun;3(3):717-42

Department of Computer Science, University of California at Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1142/s0219720005001259DOI Listing
June 2005

Covalent reaction intermediate revealed in crystal structure of the Geobacillus stearothermophilus carboxylesterase Est30.

J Mol Biol 2004 Sep;342(2):551-61

Department of Biology, Molecular Basis of Disease Program, Georgia State University, Atlanta, GA 30303, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.06.069DOI Listing
September 2004

Protein structure alignment and fast similarity search using local shape signatures.

J Bioinform Comput Biol 2004 Mar;2(1):215-39

Department of Computer Science, University of California at Santa Barbara, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1142/s0219720004000533DOI Listing
March 2004

Crystallization and preliminary X-ray diffraction data for the carboxylesterase Est30 from Bacillus stearothermophilus.

Acta Crystallogr D Biol Crystallogr 2003 Aug 23;59(Pt 8):1472-3. Epub 2003 Jul 23.

Biology Department, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1107/s0907444903011405DOI Listing
August 2003

FPV: fast protein visualization using Java 3D.

Bioinformatics 2003 May;19(8):913-22

Department of Computer Science, University of California at Santa Barbara, Santa Barbara, CA 93117-5110, USA.

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http://dx.doi.org/10.1093/bioinformatics/btg104DOI Listing
May 2003

Combining mutations in HIV-1 protease to understand mechanisms of resistance.

Proteins 2002 Jul;48(1):107-16

Department of Biology, Georgia State University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1002/prot.10140DOI Listing
July 2002

Crystal structures of Tcl1 family oncoproteins and their conserved surface features.

ScientificWorldJournal 2002 Jul 4;2:1876-84. Epub 2002 Jul 4.

Department of Biology, Georgia State University, Atlanta, GA, USA.

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http://dx.doi.org/10.1100/tsw.2002.826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009430PMC
July 2002

Crystal Structure of Murine Tcl1 Oncoprotein and Conserved Surface Features of the Molecules of the Tcl1 Family.

ScientificWorldJournal 2002 19;2:119-120. Epub 2002 Apr 19.

Departments of Biology and Chemistry, Georgia State University, Atlanta, GA;, USA.

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http://dx.doi.org/10.1100/tsw.2002.56DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009239PMC
April 2002