Publications by authors named "Yuan Jiang"

556 Publications

Higher Serum Bilirubin Levels in Response to Higher Carbohydrate Intake During Early Pregnancy and Lower Gestational Diabetes Mellitus Occurrence in Overweight and Obese Gravidae.

Front Nutr 2021 30;8:701422. Epub 2021 Aug 30.

Department of Clinical Epidemiology & Clinical Trial Unit (CTU), Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Serum bilirubin levels are recently shown to be a novel protector of gestational diabetes mellitus (GDM), yet whether they could be affected by carbohydrate quality is unclear. We aimed to examine the associations between dietary carbohydrate parameters and serum bilirubin levels during early pregnancy, with further exploration on a potential mediating role of serum bilirubin levels on carbohydrate parameters-GDM pathways. 260 healthy but overweight or obese gravidae (BMI ≥24 kg/m) derived from a historical cohort in two hospitals in China were included. The associations between carbohydrate parameters (total carbohydrate intake, glycemic index GI, fiber intake, glycemic load GL) and serum bilirubin levels (total bilirubin, TB and direct bilirubin, DB) and GDM were evaluated by multivariable regression analysis. Generalized structural equation modeling was then applied to perform adjusted mediation analysis. Increased serum bilirubin levels (mmol/L) and decreased GDM occurrence were observed following dietary carbohydrate intake (%E) and GL (g/1,000 kcal) in highest tertile compared to the lowest tertile [carbohydrate: TB: β = 0.926 (95%CI: 0.069, 1.782), DB: β = 0.554 (95%CI: 0.192, 0.916);GL:TB: β = 1.170 (95%CI: 0.339, 2.001); DB: β = 0.369 (95%CI: 0.016, 0.700); carbohydrate: adjusted OR = 0.43 (95%CI:0.19-0.99); GL: adjusted OR = 0.36 (95%CI:0.16, 0.84)]. The mediating effect of carbohydrate intake and GL on GDM through bilirubin levels was evaluated as modest (carbohydrate: 6.2% for TB, 1.3% for DB; GL: 8.7% for TB, 2.3% for DB). No association was observed regarding GI and fiber. Mildly elevated serum bilirubin levels appeared to be in response to higher energies consumed from carbohydrate during early pregnancy in healthy overweight or obese gravidae. However, the mediating effect of bilirubin levels on carbohydrate-GDM pathways is not evident. Larger investigation is further needed for solid evidence.
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http://dx.doi.org/10.3389/fnut.2021.701422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435579PMC
August 2021

Prognostic impact of tumor length in esophageal Cancer: a systematic review and Meta-analysis.

BMC Cancer 2021 Sep 3;21(1):988. Epub 2021 Sep 3.

Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing wu Road, Jinan, 250021, Shandong, China.

Background: In clinical studies, it has been observed that esophageal cancer (EC) patient prognosis can be very different even for those patients with tumors of the same TNM stage. Tumor length has been analysed as a possible independent prognostic factor in many studies, but no unanimous conclusion has been reached. Therefore, this review used a meta-analysis to evaluate the association between tumor length and prognosis in EC patients.

Methods: A systematic search for relevant articles was performed in PubMed, Web of Science, and Embase. Hazard ratios (HRs) and 95% confidence intervals (CIs) were used as effective measures to estimate the correlation between tumor length and prognosis, including overall survival, disease-free survival, progression-free survival, disease-specific survival, and cancer-specific survival. STATA 15.0 software was used to perform the meta-analysis and the data synthesis.

Results: Finally, 41 articles with 28,973 patients were included in our study. The comprehensive statistical results showed that long tumors are an independent prognostic parameter associated with poor overall survival (OS) (HR = 1.30; 95% CI: 1.21-1.40, p < .001) and disease-free survival (DFS) (HR = 1.38; 95% CI: 1.18-1.61, p < .001) in EC patients. Subgroup analyses also suggested a significant correlation between long tumors and poor OS. Sensitivity analysis and publication bias evaluation confirmed the reliability and stability of the results. Similar results were obtained in the analyses of progression-free survival (PFS), disease-specific survival (DSS), and cancer-specific survival (CSS).

Conclusion: The results of this meta-analysis showed that long tumors were related to poor OS, DFS, PFS, DSS and CSS in EC patients. Tumor length might be an important predictor of prognosis in EC patients, and it can be used as an independent staging index. Further well-designed and large-scale prospective clinical studies are needed to confirm these findings.
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http://dx.doi.org/10.1186/s12885-021-08728-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417991PMC
September 2021

Engineered Exosomes: a Promising Drug Delivery Strategy for Brain Disease.

Curr Med Chem 2021 Sep 2. Epub 2021 Sep 2.

Department of Rehabilitation Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Exosomes are a heterogeneous group of nano-sized natural membrane vesicles released from various cells and exist in body fluids. Different from the previous understanding of the function of exosomes as "garbage bins", exosomes act as carriers with many kinds of bioactive molecules (e.g., proteins, lipids, and nucleic acids) to play an important role in cell-cell communication. Growing evidence in recent years has suggested that exosomes also play some roles in the pathogenesis, diagnosis, and treatment modalities of some brain diseases, including ischemic stroke, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and brain cancers. Exosomes as therapeutic drug carriers for brain drug delivery have received extensive attention as well as exosomes can overcome the blood-brain barrier (BBB). However, the low targeting ability and size-dependent cellular uptake of native exosomes could profoundly affect the delivery performance of exosomes. Recent studies have indicated that engineered exosomes can increase the drug uptake efficiency and the subsequent drug efficacy. In the present paper, we will briefly introduce the engineering methods and applications of engineered exosomes in the treatment of brain diseases, and then focus on discussing the advantages and challenges of exosome-based drug delivery platforms to further enrich and boost the development of exosomes as a promising drug delivery strategy for brain diseases.
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http://dx.doi.org/10.2174/0929867328666210902142015DOI Listing
September 2021

Nitric oxide-releasing poly(ε-caprolactone)/S-nitrosylated keratin biocomposite scaffolds for potential small-diameter vascular grafts.

Int J Biol Macromol 2021 Aug 24;189:516-527. Epub 2021 Aug 24.

Department of Cardiothoracic Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, 1678 Dong Fang Road, Shanghai 200127, PR China. Electronic address:

Rapid endothelialization and regulation of smooth muscle cell proliferation are crucial for small-diameter vascular grafts to address poor compliance, thromboembolism, and intimal hyperplasia, and achieve revascularization. As a gaseous signaling molecule, nitric oxide (NO) regulates cardiovascular homeostasis, inhibits blood clotting and intimal hyperplasia, and promotes the growth of endothelial cells. Due to the instability and burst release of small molecular NO donors, a novel biomacromolecular donor has generated increasing interest. In the study, a low toxic NO donor of S-nitrosated keratin (KSNO) was first synthesized and then coelectrospun with poly(ε-caprolactone) to afford NO-releasing small-diameter vascular graft. PCL/KSNO graft was capable to generate NO under the catalysis of ascorbic acid (Asc), so the graft selectively elevated adhesion and growth of human umbilical vein endothelial cells (HUVECs), while inhibited the proliferation of human aortic smooth muscle cells (HASMCs) in the presence of Asc. In addition, the graft displayed significant antibacterial properties and good blood compatibility. Animal experiments showed that the biocomposite graft could inhibit thrombus formation and preserve normal blood flow via single rabbit carotid artery replacement for 1 month. More importantly, a complete endothelium was observed on the lumen surface. Taken together, PCL/KSNO small-diameter vascular graft has potential applications in vascular tissue engineering with rapid endothelialization and vascular remolding.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.08.147DOI Listing
August 2021

Early Prediction of Left Ventricular Reverse Remodeling in First-Diagnosed Idiopathic Dilated Cardiomyopathy: A Comparison of Linear Model, Random Forest, and Extreme Gradient Boosting.

Front Cardiovasc Med 2021 4;8:684004. Epub 2021 Aug 4.

Cardiovascular Medicine Department, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Left ventricular reverse remodeling (LVRR) is associated with decreased cardiovascular mortality and improved cardiac survival and also crucial for therapeutic options. However, there is a lack of an early prediction model of LVRR in first-diagnosed dilated cardiomyopathy. This single-center study included 104 patients with idiopathic DCM. We defined LVRR as an absolute increase in left ventricular ejection fraction (LVEF) from >10% to a final value >35% and a decrease in left ventricular end-diastolic diameter (LVDd) >10%. Analysis features included demographic characteristics, comorbidities, physical sign, biochemistry data, echocardiography, electrocardiogram, Holter monitoring, and medication. Logistic regression, random forests, and extreme gradient boosting (XGBoost) were, respectively, implemented in a 10-fold cross-validated model to discriminate LVRR and non-LVRR, with receiver operating characteristic (ROC) curves and calibration plot for performance evaluation. LVRR occurred in 47 (45.2%) patients after optimal medical treatment. Cystatin C, right ventricular end-diastolic dimension, high-density lipoprotein cholesterol (HDL-C), left atrial dimension, left ventricular posterior wall dimension, systolic blood pressure, severe mitral regurgitation, eGFR, and NYHA classification were included in XGBoost, which reached higher AU-ROC compared with logistic regression (AU-ROC, 0.8205 vs. 0.5909, = 0.0119). Ablation analysis revealed that cystatin C, right ventricular end-diastolic dimension, and HDL-C made the largest contributions to the model. Tree-based models like XGBoost were able to early differentiate LVRR and non-LVRR in patients with first-diagnosed DCM before drug therapy, facilitating disease management and invasive therapy selection. A multicenter prospective study is necessary for further validation. http://www.chictr.org.cn/usercenter.aspx (ChiCTR2000034128).
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http://dx.doi.org/10.3389/fcvm.2021.684004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371915PMC
August 2021

Radiomics Analysis Based on Automatic Image Segmentation of DCE-MRI for Predicting Triple-Negative and Nontriple-Negative Breast Cancer.

Comput Math Methods Med 2021 10;2021:2140465. Epub 2021 Aug 10.

Department of Radiology, Peking University First Hospital, Beijing, China.

Purpose: To investigate whether quantitative radiomics features extracted from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) could be used to differentiate triple-negative breast cancer (TNBC) and nontriple-negative breast cancer (non-TNBC).

Materials And Methods: This retrospective study included DCE-MRI images of 81 breast cancer patients (44 TNBC and 37 non-TNBC) from August 2018 to October 2019. The MR scans were achieved at a 1.5 T MR scanner. For each patient, the largest tumor mass was selected to analyze. Three-dimensional (3D) images of the regions of interest (ROIs) were automatically segmented on the third DCE phase by a deep learning segmentation model; then, the ROIs were checked and revised by 2 radiologists. DCE-MRI radiomics features were extracted from the 3D tumor volume. The patients were randomly divided into training ( = 57) and test ( = 24) cohorts. The machine learning classifier was built in the training dataset, and 5-fold cross-validation was performed on the training cohort to train and validate. The data of the test cohort were used to investigate the predictive power of the radiomics model in predicting TNBC and non-TNBC. The performance of the model was evaluated by the area under receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity.

Results: The radiomics model based on 15 features got the best performance. The AUC achieved 0.741 for the cross-validation, and 0.867 for the independent testing cohort.

Conclusion: The radiomics model based on automatic image segmentation of DCE-MRI can be used to distinguish TNBC and non-TNBC.
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http://dx.doi.org/10.1155/2021/2140465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371618PMC
August 2021

Integrated Capture and Conversion of CO2 to Methane using a Water-lean, Post-Combustion CO2 Capture Solvent.

ChemSusChem 2021 Aug 21. Epub 2021 Aug 21.

PNNL: Pacific Northwest National Laboratory, EED, UNITED STATES.

Integrated Carbon Capture and Conversion of CO 2 into materials (IC 3 M) is an attractive solution to meet global energy demand, reduce our dependence on fossil fuels, and lower CO 2 emissions. Herein, using a water-lean post-combustion capture solvent, (N-(2-ethoxyethyl)-3-morpholinopropan-1-amine) (2-EEMPA), >90% conversion of captured CO 2 to hydrocarbons, mostly methane, is achieved in the presence of a heterogenous Ru catalysts under relatively mild reaction conditions (170 ° C and <15 bar H 2 pressure). The catalytic performance was better in 2-EEMPA than aqueous 5M monoethanol amine (MEA). Operando nuclear magnetic resonance (NMR) study showed in situ formation of N-formamide intermediate, which underwent further hydrogenation to form methane and other higher hydrocarbons. The technoeconomic analyses (TEA) showed that the proposed integrated process can potentially improve the thermal efficiency by 5% and reduce the total capital investment and minimum synthetic natural gas (SNG) selling price by 32% and 12% respectively compared to conventional Sabatier process, highlighting the energetic and economic benefits of integrated capture and conversion. Methane derived from CO 2 and renewable H 2 sources is an attractive fuel, and it has great potential as a renewable hydrogen carrier as an environmentally responsible carbon capture and utilization approach.
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http://dx.doi.org/10.1002/cssc.202101590DOI Listing
August 2021

Deep whole-genome sequencing reveals no evidence for heteroresistance influencing treatment outcomes among drug-susceptible tuberculosis patients.

Tuberculosis (Edinb) 2021 Aug 14;130:102120. Epub 2021 Aug 14.

Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. Electronic address:

The purpose of this study was to investigate the minimum level of heteroresistance that predicts poor tuberculosis treatment outcomes. This retrospective study enrolled 45 new tuberculosis patients with varied treatment outcomes and 16 drug-susceptible retreatment cases. Pretreatment isolates from these 61 patients were whole genome sequenced to detect heteroresistance. Heteroresistance was not found in isolates from any of the new patients, but was detected in isolates from retreatment patients who were nevertheless cured. The results of our small series of patients suggest that heteroresistance <1%, the threshold used to define resistance with the phenotypic proportion method, is not associated with poor treatment outcomes.
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http://dx.doi.org/10.1016/j.tube.2021.102120DOI Listing
August 2021

The complete chloroplast genome sequence of var. H.Li & R.J.Mitchell and its phylogenetic analysis.

Mitochondrial DNA B Resour 2021 27;6(9):2503-2504. Epub 2021 Jul 27.

College of Pharmaceutical Science, Dali University, Dali, China.

var. is a medicinal plant commonly used in the southwest of China. This study characterized the complete chloroplast (cp) genome sequence of var. to investigate its phylogenetic relationship in Melanthiaceae. The cp genome of var. is 165,079 base pairs (bp) in length with 36.96% G + C content. The cp genome is divided into (a) large single copy (LSC) (84,393 bp), (b) small single copy (SSC) (16,066 bp), and (c) two inverted regions (32,310 bp). The cp genome contains 135 genes, including 89 protein-coding genes, 38 tRNA genes, and 8 rRNA genes. Phylogenetic analysis indicated that var. is closest to var. , and had a close relationship with in Melanthiaceae.
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http://dx.doi.org/10.1080/23802359.2021.1959450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330706PMC
July 2021

Fine or Gross Motor Index as a Simple Tool for Predicting Cognitive Impairment in Elderly People: Findings from The Irish Longitudinal Study on Ageing (TILDA).

J Alzheimers Dis 2021 Aug 6. Epub 2021 Aug 6.

Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Several kinds of motor dysfunction can predict future cognitive impairment in elderly individuals. However, the ability of the fine motor index (FINEA) and gross motor index (GROSSA) to predict the risk of cognitive impairment has not been assessed.

Objective: We investigated the associations between FINEA/GROSSA and cognitive impairment.

Methods: The data of 4,745 participants from The Irish Longitudinal Study on Ageing (TILDA) were analyzed. Cognitive function was assessed using the Mini-Mental State Examination (MMSE). We first assessed the correlation between the FINEA GROSSA and MMSE in a cross-sectional study. Then, we further investigated the predictive role of the incidence of cognitive impairment in a prospective cohort study.

Results: We found that both FINEA and GROSSA were negatively correlated with MMSE in both the unadjusted (FINEA: B = -1.00, 95%confidence intervals (CI): -1.17, -0.83, t = -11.53, p <  0.001; GROSSA: B = -0.85, 95%CI: -0.94, -0.76, t = -18.29, p <  0.001) and adjusted (FINEA: B = -0.63, 95%CI: -0.79, -0.47, t = -7.77, p <  0.001; GROSSA: B = -0.57, 95%CI: -0.66, -0.48, t = -12.61, p <  0.001) analyses in a cross-sectional study. In a prospective cohort study, both high FINEA and high GROSSA were associated with an increased incidence of cognitive function impairment (FINEA: adjusted odds ratios (OR) = 2.35, 95%CI: 1.05, 5.23, p = 0.036; GROSSA adjusted OR = 3.00, 95%CI: 1.49, 6.03, p = 0.002) after 2 years of follow-up.

Conclusion: Higher FINEA and GROSSA scores were both associated with an increased incidence of cognitive impairment. FINEA or GROSSA might be a simple tool for identifying patients with cognitive impairment.
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http://dx.doi.org/10.3233/JAD-210704DOI Listing
August 2021

Compressed-sensing accelerated magnetic resonance imaging of inner ear.

J Appl Clin Med Phys 2021 Sep 4;22(9):332-338. Epub 2021 Aug 4.

Department of Radiology, Peking University First Hospital, Beijing, 100034, China.

Objective: To compare conventional method and compressed-sensing (CS) accelerated 3D balanced fast field echo imaging (bFFE) of inner ear.

Methods: Twenty patients with suspected inner ear disease underwent CS accelerated 3D-bFFE (CS-bFFE) and conventional 3D-bFFE (Con-bFFE) by a 3T MRI. The overall image quality, motion artifacts, and image quality of specific structures of inner ear were assessed on ordinal scales by three radiologists who were blinded to the scan protocols. Kendall W test was used to evaluate interobserver agreement and Wilcoxon test was performed to compare the image quality and motion artifacts between CS-bFFE and Con-bFFE.

Results: The acquisition duration of CS-bFFE (1 min 53 s) was 49% faster than Con-bFFE. Three radiologists had good inter-observer agreement of image quality (Kendall W value of 0.829 for CS-bFFE and 0.815 for Con-bFFE) and motion artifacts evaluation (Kendall W value of 0861 for CS-bFFE and 0.707 for Con-bFFE). The better overall image quality of CS-bFFE was assessed (4.93 ± 0.23 for CS-bFFE, 4.53 ± 0.70 for Con-bFFE, Z = -2.254, p = 0.024). The image quality score of facial and cochlear nerve gained higher in CS-bFFE (4.93 ± 0.23 for CS-bFFE, 4.58 ± 0.64 for Con-bFFE, Z = -2.094, p = 0.036). No significant difference of motion artifacts (p = 0.050) between CS-bFFE and Con-bFFE.

Conclusions: The CS-bFFE improves image quality and reduces acquisition time significantly, and it is a feasible MRI protocol for inner ear imaging.
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http://dx.doi.org/10.1002/acm2.13383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8425888PMC
September 2021

Antioxidant and multi-sensitive PNIPAAm/keratin double network gels for self-stripping wound dressing application.

J Mater Chem B 2021 Aug 28;9(31):6212-6225. Epub 2021 Jul 28.

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.

Hydrogel is a potential wound dressing material due to its ability to maintain a humid environment, the strong absorptive capacity of exuded tissue fluid, and gas exchange function. Herein, poly(N-isopropyl acrylamide)/keratin double network (PNIPAAm/keratin DN) gels were fabricated through covalent and ionic double cross-linking strategy. The effects of PNIPAAm/keratin ratios on the morphology and swelling rate of gels were characterized. The DN gels could swell up from 2600% to 4600% in proportion to the keratin content, demonstrating their great ability to absorb tissue fluid. The gels possessed thermo-sensitiveness, imparting self-stripping property. Moreover, the antibacterial chlorhexidine acetate (CHX) was loaded into gels with a post-fabrication drug-loading strategy. The release behavior showed that CHX-loaded DN gels exhibited multiple responsive characteristics (temperature, pH, and ROS). Furthermore, the drug-loaded gels showed greater antibacterial activity than free CHX due to the sustained drug release effect. Meanwhile, the antioxidant efficiency of PNIPAAm/keratin DN gels was ca. 33.1%, while the PNIPAAm gel was just ca. 18.2%, indicating the strong oxidation resistance of DN gels. In the Sprague Dawley (SD) rat skin defect model, the hydrogel had better tissue regeneration ability than the commercial film. Taken together, the multifunctional PNIPAAm/keratin DN gels are potential candidates for clinical wound treatment.
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http://dx.doi.org/10.1039/d1tb00702eDOI Listing
August 2021

Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.

Nat Commun 2021 07 16;12(1):4362. Epub 2021 Jul 16.

Department of Medicine, Samuel Oschin Cancer Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Squamous cell carcinomas (SCCs) comprise one of the most common histologic types of human cancer. Transcriptional dysregulation of SCC cells is orchestrated by tumor protein p63 (TP63), a master transcription factor (TF) and a well-researched SCC-specific oncogene. In the present study, both Gene Set Enrichment Analysis (GSEA) of SCC patient samples and in vitro loss-of-function assays establish fatty-acid metabolism as a key pathway downstream of TP63. Further studies identify sterol regulatory element binding transcription factor 1 (SREBF1) as a central mediator linking TP63 with fatty-acid metabolism, which regulates the biosynthesis of fatty-acids, sphingolipids (SL), and glycerophospholipids (GPL), as revealed by liquid chromatography tandem mass spectrometry (LC-MS/MS)-based lipidomics. Moreover, a feedback co-regulatory loop consisting of SREBF1/TP63/Kruppel like factor 5 (KLF5) is identified, which promotes overexpression of all three TFs in SCCs. Downstream of SREBF1, a non-canonical, SCC-specific function is elucidated: SREBF1 cooperates with TP63/KLF5 to regulate hundreds of cis-regulatory elements across the SCC epigenome, which converge on activating cancer-promoting pathways. Indeed, SREBF1 is essential for SCC viability and migration, and its overexpression is associated with poor survival in SCC patients. Taken together, these data shed light on mechanisms of transcriptional dysregulation in cancer, identify specific epigenetic regulators of lipid metabolism, and uncover SREBF1 as a potential therapeutic target and prognostic marker in SCC.
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http://dx.doi.org/10.1038/s41467-021-24656-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285542PMC
July 2021

Imported human norovirus in travelers, Shanghai port, China 2018: An epidemiological and whole genome sequencing study.

Travel Med Infect Dis 2021 Sep-Oct;43:102140. Epub 2021 Jul 13.

Shanghai International Travel Healthcare Center, Shanghai Customs District PR China, Shanghai, 200335, China. Electronic address:

Background: Global mobility of the population has accelerated spread of the Human Norovirus (HuNoV), with long-distance travel in enclosed spaces increasing the opportunity for viral outbreaks. However, surveillance of HuNoV transmission is still lacking, especially in cross-border transportation.

Method: From 533 self-reported patients, 83 swab samples (15.6%) tested positive for HuNoV by RT-qPCR. Positive samples were sequenced using next-generation sequencing (NGS). Epidemiological investigation and whole genome analysis were then conducted.

Results: Most cases occurred in February and March, with large outbreaks involving more than 34 people. A total of 74 HuNoV sequences that could be genotyped were obtained, with near-complete genomes (>7 kb) accounting for most sequences (57/74). A total of 19 different genotypes of viral whole genome sequences were included. The first whole genome sequence of GII.9[P7] was obtained. Rarely reported genotypes including GI.3[P10], GI.3[P13], GII.7[P7], GII.8[P8], and GIX.1[GII.P15] were sequenced and assembled successfully. Four possible sources of virus outbreaks in China were traced. Beyond HuNoV, whole genome sequences of food-borne viruses including Salivirus, Kobuvirus, and Enterovirus were obtained in further assembly.

Conclusions: Surveillance of the etiology and epidemiology of HuNoV global spread through travelers will improve pre-travel health advice, empirical treatment, and estimates of vaccine-preventable diseases.
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http://dx.doi.org/10.1016/j.tmaid.2021.102140DOI Listing
July 2021

Spontaneous Adsorption of Graphene Oxide on Multiple Polymeric Surfaces.

Langmuir 2021 Jul 16;37(29):8829-8839. Epub 2021 Jul 16.

College of Materials, Department of Physics, Research Institute for Biomimetics and Soft Matter, Xiamen University, Graphene Industry and Engineering Research Institute, Xiamen University, Xiamen 361005, China.

The controllable integration of low-dimensional nanomaterials on solid surfaces is pivotal for the fabrication of next-generation miniaturized electronic and optoelectronic devices. For instance, organization of two-dimensional (2D) nanomaterials on polymeric surfaces paves the way for the development of flexible electronics for applications in wearable devices. Nevertheless, the understanding of the molecular interactions between these nanomaterials and the polymeric surfaces remains limited, which impedes the rational design of 2D nanomaterial-based functional coatings. In the current work, we report that graphene oxide (GO) nanosheets, in their dispersion phase, can be adsorbed on multiple polymeric surfaces in a spontaneous manner. Both experimental findings and simulational results indicate that the main driving force is hydrogen bonding interactions, although other molecular interactions such as polarity and dispersion ones contribute to the adsorption as well. The relatively high hydrogen bonding interactions cause not only increased GO surface coverage but also enhanced GO adsorption kinetics on polymeric surfaces. The adsorbed GO layers are robust, which can be explained by the large aspect ratios of GO nanosheets and the presence of multiple spots for molecular interactions. As a proof of concept, GO-covered polymethyl methacrylate effectively decreases surface static charges when compared with its pristine counterpart. The integration of the GO constituents turns many inert polymeric substrates into multifunctional hybrids, and the functional groups on GO can be used further to bridge with additional functional materials for the development of high-performance electronic devices.
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http://dx.doi.org/10.1021/acs.langmuir.1c01214DOI Listing
July 2021

Slim cigarette smoking in Urban China: Who are the early adopters and why?

PLoS One 2021 13;16(7):e0254682. Epub 2021 Jul 13.

Moores Cancer Center, University of California, San Diego, La Jolla, California, United States of America.

Sales data in China indicate that slim cigarette consumption has increased dramatically over the last few years. This study examined who smoked slim cigarettes and the reasons for adopting these new products. A survey of an online panel from 19 Chinese cities was conducted from October 2018 to April 2019 with 20,055 members aged 16 and older. Among the 31.7% [95% confidence interval (CI) = 30.1-33.4] of panel members who reported currently smoking, 37.7% (95% CI = 34.8-40.5) smoked slim cigarettes. Among smokers, women were significantly more likely to smoke slim cigarettes than men [56.5% (95% CI = 50.8-62.2) vs. 35.5% (95% CI = 32.8-38.1)]. Smokers with a bachelor's degree were more likely to smoke slim cigarettes than those without [41.3% (95% CI = 38.1-44.4) vs. 33.1% (95% CI = 30.0-36.1)]. Most slim cigarette smokers were dual smokers [77.7% (95% CI = 75.3-80.1)], smoking both regular and slim cigarettes. Among dual smokers, 97.5% (95% CI = 96.7-98.3) started smoking regular cigarettes before slim cigarettes. Of the many reasons given for smoking slim cigarettes, 37.0% (95% CI = 34.3-39.7) directly related to harm reduction with another 10.1% (95% CI = 8.4-11.7) reporting their reason as wanting "to reduce consumption of regular cigarettes," a plausible indication of harm reduction. These findings suggest strong interest in harm reduction among the current Chinese smoking population and that the popularity of slim cigarettes is likely to increase, with the more educated as the early adopters. Given the absence of any evidence that these products actually reduce harm, it is urgent that the public health community be on high alert in order to avoid repeating the sad history of low-tar cigarettes, when a supposed harm-reduction product misled the field of tobacco control.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254682PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277019PMC
July 2021

Tissue-level transcriptomic responses to local and distal chilling reveal potential chilling survival mechanisms in maize.

J Exp Bot 2021 Jul 8. Epub 2021 Jul 8.

Plant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA.

Chilling is a major stress to plants of subtropical and tropical origins including maize (Zea mays L.). To reveal molecular mechanisms underlying chilling tolerance and survival, we investigated transcriptomic responses to chilling stress in differentiated leaves and roots as well as in crowns with meristem activity in maize. Chilling stress on shoots and roots is found to each contributes to seedling lethality in maize. Comparison of maize lines with different chilling tolerance capacities reveals that chilling survival is highly associated with upregulation of abscisic acid biosynthesis and response as well as transcriptional regulators in leaves and crowns. It is also associated with the downregulation of translation in leaves and heat response in crowns. Chilling treatment on whole or part of the plants reveals that response to distal-chilling is very distinct from, and sometimes opposite to, response to local- or whole-plant chilling in both leaves and roots, suggesting a communication between shoots and roots in environmental response. This study thus provides transcriptomic responses in leaves, roots and crowns under differential chilling stresses in maize and reveals potential chilling tolerance and survival mechanisms which lays ground for improving chilling tolerance in crop plants.
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http://dx.doi.org/10.1093/jxb/erab323DOI Listing
July 2021

Biocompatible and photocrosslinkable poly(ethylene glycol)/keratin biocomposite hydrogels.

J Biomater Sci Polym Ed 2021 Jul 28:1-11. Epub 2021 Jul 28.

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, P. R. China.

A biocompatible hydrogel is ideal for tissue engineering and regeneration. In this study, methacrylated keratin (KerMA) was synthesized for the first time and then blended with poly(ethylene glycol dimethacrylate) (PEGDMA) to form hydrogel through photocrosslinking. The chemical structure, gelation time, swelling behavior, hydrophilicity, cytotoxicity, and 3D printability of PEGDMA/KerMA hydrogels were characterized and exploited. The PEGDMA/KerMA hydrogels performed good cytocompatibility, providing potential applications for tissue engineering and regenerative medicine.
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http://dx.doi.org/10.1080/09205063.2021.1952384DOI Listing
July 2021

A systematic study on the chemical diversity and efficacy of the inflorescence and succulent stem of Cynomorium songaricum.

Food Funct 2021 Aug 5;12(16):7501-7513. Epub 2021 Jul 5.

Key Laboratory of Chinese Medicine Resources Conservation, State Administration of Traditional Chinese Medicine of the People's Republic of China, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Cynomorium songaricum is a medicinal, edible, and endangered plant species. Since inflorescences are not considered medicinal parts, their discard causes a waste of resources. To expand the medicinal uses of C. songaricum, we evaluated their chemistry and pharmacology by applying widely targeted metabolomics, network pharmacology, and molecular docking. Widely targeted metabolomics results indicated chemical diversity in C. songaricum with 599 compounds. Among them, 280 compounds were different between the succulent stem and inflorescence. With 218 upregulated compounds, inflorescence has more abundant compounds than the succulent stem, especially pigment compounds such as flavonols, flavones, and flavanones. Moreover, anthocyanin and proanthocyanidin were unique compounds in the inflorescence and succulent stem, respectively. Sixty-five compounds in inflorescence and 18 compounds in succulent stems were found to be associated with atherosclerosis in the network pharmacology analysis. Tests revealed that inflorescence had a stronger anti-atherosclerotic effect than succulent stems. Molecular docking analysis revealed that 30 compounds (29 pigment compounds) in inflorescence and 6 compounds (4 pigment compounds) in succulent stem showed strong binding affinities with three target proteins, namely ALB, MPO, and NOS, especially amentoflavone, quercetin 7-O-rutinoside, and luteolin 7-O-glucoside (cynaroside). Results demonstrated that the inflorescence is rich in pigment compounds and has a potential anti-atherosclerosis effect. This study provides novel methods and ideas for the sustainable development of endangered medicinal plants.
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http://dx.doi.org/10.1039/d1fo01275dDOI Listing
August 2021

Discovery of heterocyclic substituted dihydropyrazoles as potent anticancer agents.

Bioorg Med Chem Lett 2021 Sep 29;48:128233. Epub 2021 Jun 29.

School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, PR China. Electronic address:

In this work, a series of novel heterocyclic substituted dihydropyrazole derivatives have been prepared, and in vitro anticancer activity against a panel of human tumor cell lines by SRB were evaluated. The results indicated that piperazine substituted dihydropyrazole derivatives exhibited superior anticancer activity than that of other compounds. Especially, compounds 4g, 4h, 4l, 4m, 4o, 6g, 6j and 6l showed potent antitumor activity. Further mechanism study demonstrated that compound 4o could induce G2/M arrest in HCC1806 cell and p21 accumulation significantly.
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http://dx.doi.org/10.1016/j.bmcl.2021.128233DOI Listing
September 2021

Relationships Between Leaf Carbon and Macronutrients Across Woody Species and Forest Ecosystems Highlight How Carbon Is Allocated to Leaf Structural Function.

Front Plant Sci 2021 11;12:674932. Epub 2021 Jun 11.

Key Laboratory of Ecosystem Network Observation and Modeling, Center for Forest Ecosystem Studies and Qianyanzhou Ecological Station, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China.

Stoichiometry of leaf macronutrients can provide insight into the tradeoffs between leaf structural and metabolic investments. Structural carbon (C) in cell walls is contained in lignin and polysaccharides (cellulose, hemicellulose, and pectins). Much of leaf calcium (Ca) and a fraction of magnesium (Mg) were further bounded with cell wall pectins. The macronutrients phosphorus (P), potassium (K), and nitrogen (N) are primarily involved in cell metabolic functions. There is limited information on the functional interrelations among leaf C and macronutrients, and the functional dimensions characterizing the leaf structural and metabolic tradeoffs are not widely appreciated. We investigated the relationships between leaf C and macronutrient (N, P, K, Ca, Mg) concentrations in two widespread broad-leaved deciduous woody species (90 individuals) and (47 individuals), and further tested the generality of the observed relationships in 222 woody eudicots from 15 forest ecosystems. In a subsample of 20 broad-leaved species, we also analyzed the relationships among C, Ca, lignin, and pectin concentrations in leaf cell walls. We found a significant leaf C-Ca tradeoff operating within and across species and across ecosystems. This basic relationship was explained by variations in the share of cell wall lignin and pectin investments at the cell scale. The C-Ca tradeoffs were mainly driven by soil pH and mean annual temperature and precipitation, suggesting that leaves were more economically built with less C and more Ca as soil pH increased and at lower temperature and lower precipitation. However, we did not detect consistent patterns among C-N, and C-Mg at different levels of biological organization, suggesting substantial plasticity in N and Mg distribution among cell organelles and cell protoplast and cell wall. We observed two major axes of macronutrient differentiation: the cell-wall structural axis consisting of protein-free C and Ca and the protoplasm metabolic axis consisting of P and K, underscoring the decoupling of structural and metabolic elements inherently linked with cell wall from protoplasm investment strategies. We conclude that the tradeoffs between leaf C and Ca highlight how carbon is allocated to leaf structural function and suggest that this might indicate biogeochemical niche differentiation of species.
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http://dx.doi.org/10.3389/fpls.2021.674932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226226PMC
June 2021

Maternal serum 25-hydroxyvitamin D levels and infant atopic dermatitis: A prospective cohort study.

Pediatr Allergy Immunol 2021 Jun 23. Epub 2021 Jun 23.

Department of Clinical Epidemiology and Clinical Trial Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.

Background: Maternal vitamin D status during pregnancy has been linked with the risk of atopic dermatitis (AD) in children, while the results were inconsistent. The objective of this study was to assess the potential association.

Methods: Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in pregnant women from the birth cohort MKFOAD. Infant AD was diagnosed according to Williams' criteria. Multivariate logistic regression model was used to examine the association of maternal serum 25(OH)D levels in the first, second, and third trimester of gestation with the risk of infant AD at first year of age.

Results: In total, 121 (26.5%) of 456 infants developed AD prior to 1 year of age. In general, higher maternal serum 25(OH)D levels throughout pregnancy were associated with increased risks of AD in infants prior to 1 year of age in multivariate logistic regression models, with borderline statistical significance in the first (per ln unit increase: adjusted OR = 1.93, 95% CI: 0.96, 3.88) and second (per ln unit increase: adjusted OR = 1.72, 95% CI: 0.93, 3.19) trimester. Multivariate logistic regression models using categorical variables of maternal 25(OH)D levels by tertiles showed similar results: Infants born to mothers with serum 25(OH)D levels in the highest tertile had higher risk of AD than those with 25(OH)D in the lowest tertile.

Conclusions: The present study found some evidence supporting that higher maternal 25(OH)D levels during pregnancy increased the risk of infant AD. However, the clinical implication of the findings should be limited for those with blood levels over the recommendations.
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http://dx.doi.org/10.1111/pai.13582DOI Listing
June 2021

Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer.

Front Oncol 2021 2;11:647559. Epub 2021 Jun 2.

Department of Scientific Research Office, Affiliated Hospital of Qinghai University, Xining, China.

Lactate has been observed to fuel TCA cycle and is associated with cancer progression in human lung cancer, the leading cause of cancer deaths worldwide, but the effect of lactate on lung cancer metabolism is rarely reported. In this study, disordered metabolism in non-small cell lung cancer was demonstrated by increased G6PD and SDHA protein levels immunofluorescence, and up-regulated lactate dehydrogenase was found to be associated with poor prognosis. Then flow cytometry and Seahorse XFe analyzer were utilized to detect the effect of lactate on glycolysis and mitochondrial function in non-small cell lung cancer cells. The results show that in non-small cell lung cancer cells lactate attenuates glucose uptake and glycolysis while maintaining mitochondrial homeostasis as indicated by improved mitochondrial membrane potential. Further exploration found that mRNA levels of glycolytic enzymes (, ) and TCA cycle enzymes (, ) are respectively down-regulated and up-regulated by lactate, and increased histone lactylation was observed in promoters of and chromatin immunoprecipitation assay. Taken together, the above results indicate that lactate modulates cellular metabolism at least in part through histone lactylation-mediated gene expression in non-small cell lung cancer.
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http://dx.doi.org/10.3389/fonc.2021.647559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208031PMC
June 2021

Does Goal Conflict Necessarily Undermine Wellbeing? A Moderated Mediating Effect of Mixed Emotion and Construal Level.

Front Psychol 2021 2;12:653512. Epub 2021 Jun 2.

Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, Beijing, China.

Development occurs through the process of setting and working toward goals, in which individuals are often working toward multiple goals that are likely to conflict with one another. Although motivation theories hold that goal conflict is a kind of potential stress that may damage individuals' mental health and wellbeing, the empirical research results on the relationship between goal conflict and wellbeing are quite different. There may be unknown factors affecting the relationship between the two. Against this background, we conducted the exploration of the relationship between goal conflict and life satisfaction, mainly by analyzing the moderated mediating effect of mixed emotions and construal level. The results showed that the goal conflict did not directly affect life satisfaction ( = -0.01, > 0.5) but indirectly influenced life satisfaction through mixed emotions ( = -0.17, < 0.001). The construal level moderated the relationship between mixed emotions and life satisfaction ( = -0.08, < 0.01), and the higher construal level will predict higher life satisfaction especially when mixed emotions were low ( - ) or medium (). Therefore, the hypothesis of moderated mediating effect is verified, and we can draw the following conclusions: (1) Goal conflict does not necessarily impair life satisfaction. (2) Goal conflict impairs life satisfaction conditional on the fact that it triggers mixed emotions. Since mixed emotions are often accompanied by feelings of ambivalence and discomfort, they reduce the individual's evaluation of life satisfaction. (3) In the path of goal conflict reducing life satisfaction through mixed emotions, the higher construal level mitigates the adverse effects of mixed emotions to some extent.
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http://dx.doi.org/10.3389/fpsyg.2021.653512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206492PMC
June 2021

Hydrogel-Mediated Mineralization Generates Oriented Crystalline Films Comprising Granular-Rhombohedral Heterogeneous Structures.

Langmuir 2021 Jun 16. Epub 2021 Jun 16.

College of Materials, Xiamen University, Xiamen 361005, P.R. China.

Gel-mediated crystallization is a common system to produce self-organized materials, which is fundamental to the development of bottom-up approaches to functional complex materials. Mineralization in hydrogel matrices nevertheless remains empirical in the generation of crystallization products with tailored heterogeneous structures. We demonstrate that the employment of the hydrogels with proper cationic diffusivity can trigger the consecutive growth of oriented, granular-rhombohedral heterogeneous structures. The controllable morphogenesis leads to continuous calcitic CaCO films comprising spatial heterogeneity, where epitaxial match assumedly favors the successive deposition of both granular and rhombohedral layers. The scenario of consecutive growth is disclosed, where the thickness of the granular layers can become a valuable indicator to reflect the retardancy degree of crystallization. The evaluation of the physicochemical properties of the hydrogels finally establishes a direct correlation between the cationic diffusivity of the hydrogels and the appearance of the heterogeneous structures. The current work therefore sheds light on the implementation of rational morphogenetic approaches to crystalline materials with tailored complex architectures.
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http://dx.doi.org/10.1021/acs.langmuir.1c00863DOI Listing
June 2021

Performance of waist-to-height ratio as a screening tool for identifying cardiometabolic risk in children: a meta-analysis.

Diabetol Metab Syndr 2021 Jun 14;13(1):66. Epub 2021 Jun 14.

Department of Clinical Epidemiology and Clinical Trial Unit, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, 201102, People's Republic of China.

Objective: To provide the latest evidence of performance and robustness of waist-to-height ratio (WHtR) in discriminating clusters of cardiometabolic risk factors (CMRs) and promote WHtR in routine primary health care practice in children, a meta-analysis was used.

Methods: Searches was performed in eight databases from inception to July 03, 2020. Inclusion criteria were: (1) observational study, (2) children and adolescents, (3) provided WHtR measurements, (4) had CMRs as outcomes, and (5) diagnostic studies. Exclusion criteria were: (1) non-original articles, (2) unable to extract 2 × 2 contingency tables, (3) not in English or Chinese language, (4) populations comprising clinical patients, or (5) duplicate articles. WHtR cutoff points, 2 × 2 contingency tables were extracted from published reports. Outcomes included: CMR clusters of at least three CMRs (CMR), two (CMR), one (CMR), and CMR components. Bivariate mixed-effects models were performed to estimate the summarised area under the curves (AUSROC) with 95% CIs and related indexes. We conducted subgroup analyses by sex and East Asian ethnicity.

Results: Fifty-three observational studies were included. The AUSROC reached 0.91 (95% CI: 0.88-0.93), 0.85 (95% CI: 0.81, 0.88) and 0.75 (95% CI: 0.71, 0.79) for CMR, CMR, and CMR, respectively. The pooled sensitivity and specificity for CMR reached 0.84 and exceeded 0.75 for CMR. For CMR, the sensitivity achieved 0.55 with 0.84 for specificity. We had similar findings for our subgroup and sensitivity analyses.

Conclusions: WHtR shows good and robust performance in identifying CMRs clustering across racial populations, suggesting its promising utility in public health practice globally.
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http://dx.doi.org/10.1186/s13098-021-00688-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201900PMC
June 2021

The Optimal Adjuvant Strategy of Aidi Injection With Gemcitabine and Cisplatin in Advanced Non-small Cell Lung Cancer: A Meta-analysis of 70 Randomized Controlled Trials.

Front Pharmacol 2021 28;12:582447. Epub 2021 May 28.

Department of General Practice, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Aidi injection (Aidi) is composed of cantharidin, astragaloside, ginsenoside, and elentheroside E. As an important adjuvant therapy, Aidi in combination with gemcitabine and cisplatin (GP) is often used in the treatment of non-small cell lung cancer (NSCLC). We performed a new evaluation to demonstrate the clinical efficacy and safety of the Aidi and GP combination and further explored an optimal strategy for achieving an ideal response and safety level in advanced NSCLC. We collected all the related trials from Chinese and English-language databases, analyzed their methodological bias risk using the Cochrane evaluation Handbook for Systematic Reviews of Interventions Version 5.1.0, extracted all the data using a predefined data extraction form, pooled the data using a series of meta-analyses, and finally summarized the quality of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. We included 70 trials with 5,509 patients. Compared with GP alone, the Aidi and GP combination showed a significant improvement in the objective response rate (ORR) [1.82 (1.62-2.04)], disease control rate (DCR) [2.29 (1.97-2.67)], and quality of life (QOL) [3.03 (2.55-3.60)] and a low incidence of hematotoxicity and gastrointestinal and hepatorenal toxicity. Aidi might be more suitable for patients who are first-treated, elderly, or patients with a Karnofsky Performance Status (KPS) score ≥ 60 or anticipated survival time (AST) ≥3 months. An Aidi (50 ml/day, 7-14 days/cycle for one to two cycles), gemcitabine (1000 mg/m), and cisplatin (20-30 mg/m, 40-50 mg/m, or 60-80 mg/m) might be an optimal regimen for realizing an ideal response and safety level. Most results were robust and of moderate quality. Current evidence indicates that Aidi's value in adjuvant chemotherapy may be broad-spectrum, not just for some regimens. The Aidi and GP combination may show a good short-term response, antitumor immunity, and safety level in patients with NSCLC. Aidi (50 ml/day, 7-14 days/cycle for one and two cycles) with GEM (1000 mg/m) and DDP (20-30 mg/m or 40-50 mg/m) may be an optimal regimen for realizing an ideal goal in patients who are first-treatment, elderly, or have a KPS score ≥ 60 or AST≥3 months.
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http://dx.doi.org/10.3389/fphar.2021.582447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8194277PMC
May 2021

Super-enhancer-mediated core regulatory circuitry in human cancer.

Comput Struct Biotechnol J 2021 5;19:2790-2795. Epub 2021 May 5.

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Super-enhancers (SEs) are congregated enhancer clusters with high level of loading of transcription factors (TFs), cofactors and epigenetic modifications. Through direct co-occupancy at their own SEs as well as each other's, a small set of so called "master" TFs form interconnected core regulatory circuitry (CRCs) to orchestrate transcriptional programs in both normal and malignant cells. These master TFs can be predicted mathematically using epigenomic methods. In this Review, we summarize the identification of SEs and CRCs in cancer cells, the mechanisms by which master TFs and SEs cooperatively regulate cancer-type-specific expression programs, and the cancer-type- and subtype-specificity of CRC and the significance in cancer biology.
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http://dx.doi.org/10.1016/j.csbj.2021.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138668PMC
May 2021

Stepwise immobilization of keratin-dopamine conjugates and gold nanoparticles on PET sheets for potential vascular graft with the catalytic generation of nitric oxide.

Colloids Surf B Biointerfaces 2021 Sep 17;205:111855. Epub 2021 May 17.

Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-Functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, PR China. Electronic address:

Gold nanoparticles(AuNPs) are capable to catalyze the nitric oxide (NO) generation from endogenous and exogenous donors, thereby promoting re-endothelialization and inhibiting intimal hyperplasia and thrombosis. Herein, keratin-dopamine conjugates were synthesized and then immobilized on the surface of the pre-aminolyzed poly(ethylene terephthalate) (PET) via self-polymerization of dopamine residue, following by the formation of AuNPs in situ without extra reductant. The modified PET sheets(PET-AuNPs) could promote the growth of HUVECs while inhibit the proliferation of HUASMCs due to their catalytic generation of NO from GSNO. In addition, these sheets exhibited antibacterial properties and good blood compatibility without hemolysis. Taken together, this strategy for designing prosthetic vascular grafts to treat cardiovascular diseases has great potential.
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http://dx.doi.org/10.1016/j.colsurfb.2021.111855DOI Listing
September 2021
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