Publications by authors named "Yu-Ping Zhang"

167 Publications

Zhikang Capsule Ameliorates Inflammation, Drives Polarization to M2 Macrophages, and Inhibits Apoptosis in Lipopolysaccharide-induced RAW264.7 Cells.

Curr Med Sci 2021 Oct 27. Epub 2021 Oct 27.

Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Objective: To explore the anti-inflammatory effect of the traditional Chinese medicine Zhikang capsule (ZKC) on lipopolysaccharide (LPS)-induced RAW264.7 cells.

Methods: Safe concentrations of ZKC (0.175, 0.35, and 0.7 mg/mL) were used after the half-maximal inhibitory concentration (IC) of RAW264.7 cells was calculated through the CCK-8 assay. In addition, the optimal intervention duration of ZKC (0.7 mg/mL) on RAW264.7 cells was determined to be 6 h, since all proinflammatory mediators [tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), inteleukin-6 (IL-6), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and monocyte chemotactic protein-1 (MCP-1)] had a decreasing tendency and relatively down-regulated mRNA expression levels as compared with other durations (4, 8, and 12 h). RAW264.7 cells were pretreated with ZKC at various concentrations (0.175, 0.35 and 0.7 mg/mL) for 6 h and then stimulated with LPS (1 µg/mL) for an additional 12 h.

Results: In terms of inflammation, ZKC could reverse LPS-induced upregulation of TNF-α, IL-1β, IL-6, COX-2, iNOS, and MCP-1 at both the mRNA and protein levels in RAW264.7 cells in a dose-dependent manner. In terms of the NF-κB signaling pathway, ZKC could reduce phosphorylated p65 and promote M2 polarization of RAW264.7 cells under LPS stimulation in a dose-dependent manner. Moreover, ZKC exhibited a protective effect on macrophages from apoptosis.

Conclusion: ZKC exhibited obvious antiinflammatory and anti-apoptotic effects on LPS-induced RAW264.7 cells at the cellular level, and a weakened NF-κB signaling pathway may be a potential significant target.
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http://dx.doi.org/10.1007/s11596-021-2441-zDOI Listing
October 2021

Ability of (Hymenoptera: Pteromalidae) to Parasitize (Diptera: Tephritidae) after Switching Hosts.

Insects 2021 Jul 7;12(7). Epub 2021 Jul 7.

Guangdong Provincial Key Laboratory of High Technology for Plant Protection/Plant Protection Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.

We studied the parasitism capacity of as a pupal parasite of after switching hosts. We used pupae of and as the hosts and studied parasitism by in the laboratory. The parasitism capacities were compared at different host densities and different parasitoid ages. The two functional responses of fitted a Holling Type II equation. More were parasitized than at all the densities. The ability of to control was / (parasitism capacity) = 32.1950, which was much stronger than that of control , which was / = 4.7380. The parasitism rate of wasps that had parasitized had decreased by the emergence time of parasitoids. These results suggest that the parasitoid-pest ratio should be 1:25 to maintain a relatively stable parasitism rate for control of The colony reared on successfully controlled a low-density population of in the lab. We provide evidence suggesting that the parasitism capacity of needs to be improved.
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http://dx.doi.org/10.3390/insects12070613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306652PMC
July 2021

[Clinical Analysis of CMV Infection after Allogeneic Hematopoietic Stem Cell Transplantation in Severe Aplastic Anemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):944-950

Department of Hematology, Guangzhou NO.1 People's Hospital, Guangzhou Medical University,Guangzhou 510180, Guangdong Province, China,E-mail:

Objective: To investigate the clinical characteristics and risk factors of cytomegalovirus (CMV) infection after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with severe aplastic anemia (SAA).

Methods: Clinical data from 270 SAA patients with allo-HSCT were retrospectively analyzed, including 108 sib congruence patients and 162 substitute donors (68 unrelated donor congruence patients and 94 related haploid patients). Different pretreatment schemes were selected for different transplantation modes. The HLA-identical sibling and haploid grafts were all bone marrow and peripheral blood stem cells, and the grafts from unrelated donors were peripheral blood stem cells. After granulocyte implantation, blood CMV-DNA was regularly monitored. Flow cytometry was also used to determine the absolute number of CD3, CD4T lymphocytes and CD19B lymphocytes at 1, 2, 3, 6 and 12 months after transplantation.

Results: CMV infection occurred in 229 of 270 patients with an incidence of 84.8%. Among them, 18 patients developed giant cell disease. Univariate analysis showed that alternative donors (unrelated total and haploid donors), mycophenolate mofetil and acute graft-versus-host disease were statistically significantly associated with CMV infection (P<0.05). Multivariate analysis showed that alternative donors were associated with CMV infection. The recovery of CD3 and CD4 in 6 months in the substitute donors was delayed in comparison with that in the full sib group.

Conclusion: After allo-HSCT, substitute donors are more easily to develop CMV infection than full-sibling donors, and the reconstruction of immune function is delayed after transplantation.
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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.03.046DOI Listing
June 2021

Do-not-resuscitate decision making for terminally ill older patients in the emergency department: An explorative, descriptive inquiry of Chinese family members.

Geriatr Nurs 2021 Jul-Aug;42(4):843-849. Epub 2021 Jun 3.

Department of Emergency Medicine, The Second Affiliated Hospital Zhejiang University School of Medicine (SAHZU), Hangzhou, Zhejiang Province, PR China.

Many terminally ill older adults depend on family members to make medical decisions in China. Many family members find it difficult to make do-not-resuscitate (DNR) decisions in emergency departments (ED). Currently, factors that affect DNR decision making by family members for older adults needing emergency care have not been well studied. This qualitative inquiry explores factors influencing DNR decision-making among family members of terminally ill older adults in ED. Semi-structured in-depth interviews were conducted for a 12-family member of terminally ill older adults at ED in China. Results of the conventional content analysis showed that family members made DNR decisions based on a wide of reasons: (a) subjective perception of family members, (b) conditions of the terminally ill older adults, (c) external environmental factors, and (d) internal family factors. The findings of this study expand our knowledge and understanding of factors influencing DNR decision-making by family members of terminally ill older adults in ED.
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http://dx.doi.org/10.1016/j.gerinurse.2021.04.021DOI Listing
October 2021

Toxicity of CuS/CdS semiconductor nanocomposites to liver cells and mice liver.

Sci Total Environ 2021 Aug 21;784:147221. Epub 2021 Apr 21.

School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, Henan 453003, China. Electronic address:

Semiconductor nanomaterials not only bring great convenience to peoples lives but also become a potential hazard to human health. The purpose of this study was to evaluate the toxicity of CuS/CdS nanocomposites in hepatocytes and mice liver. The CuS/CdS semiconductor nanocomposites were synthesized by a biomimetic synthesis - ion exchange strategy. Nanosize was confirmed by high-resolution transmission electron microscopy and dynamic light scattering. The composition and physical properties were measured by powder X-ray diffraction, Fourier transform infrared spectra, atomic absorption spectroscopy, thermogravimetry-differential scanning calorimetry and zeta potential analysis. The results revealed that CuS/CdS nanocomposites had 8.7 nm diameter and negative potential. Ion exchange time could adjust the ratio of CuS and CdS in nanocomposites. The toxicological study revealed that CuS/CdS nanocomposites could be internalized into liver cells, inhibited endogenous defense system (e.g. GSH and SOD), induced the accumulation of oxidation products (e.g. ROS, GSSG and MDA), and caused hepatocyte apoptosis. The in vivo experiments in Balb/c mice showed that the experimental dose (4 mg/kg) didn't cause observable changes in mice behavior, physical activity and pathological characteristics, but the continuous accumulation of Cd in the liver and kidney might be responsible for its long-term toxicity.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147221DOI Listing
August 2021

[Interpretation of the international expert recommendations of clinical features to prompt referral for diagnostic assessment of cerebral palsy].

Zhongguo Dang Dai Er Ke Za Zhi 2021 Apr;23(4):328-331

Department of Pediatrics, Second Affiliated Hospital of Army Medical University, Chongqing 400037, China.

Under the guidance and support of national policies in recent years, the community medical system has been developed rapidly, among which primary child healthcare is carried out routinely in community hospitals, greatly alleviating the pressure of specialized pediatric hospitals and departments of pediatrics in secondary and tertiary general hospitals. However, due to the lack of professional training for primary child healthcare personnel in community medical institutions, early symptoms of children with cerebral palsy cannot be identified and so children with cerebral palsy are often unable to receive early diagnosis and intervention, which may affect their prognosis. An article about international expert consensus and recommendations on early identification and referral of cerebral palsy in community medical institutions was published in in 2020. It proposed six clinical features that should prompt referral and two warning signs that warrant enhanced monitoring, as well as five recommendations for referral to medical experts and other healthcare professionals for the diagnosis of cerebral palsy. The recommendations may help primary child healthcare personnel in community medical institutions to early identify the children at high risk of cerebral palsy, thus reducing the delay of referral and intervention. This article gives an interpretation of the recommendations based on the actual situation in China, in order to improve the ability of primary child healthcare personnel in community medical institutions to early identify high-risk signals of cerebral palsy and conduct reasonable referral. This will help to achieve the early identification, early diagnosis, and early intervention to improve the prognosis of children with cerebral palsy.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050548PMC
April 2021

TSH adenoma and syndrome of resistance to thyroid hormones-Two cases report of syndrome of inappropriate secretion of thyrotropin.

Brain Behav 2021 05 10;11(5):e02081. Epub 2021 Mar 10.

Breast and Thyroid Surgical Department, Chongqing General Hospital, University of Chinese Academy of Sciences, Chongqing, China.

SITSH (syndrome of inappropriate secretion of thyrotropin) is a rare clinical state defined as uninhibited serum thyroid stimulating hormone in the presence of elevated thyroid hormone. This state is complicated and mainly caused by the abnormal feedback of hypothalamus-pituitary thyroid axis. The TSH adenoma (TSH-oma) and resistance to thyroid hormones (RTH) are the main etiologies of SITSH. As is well known that the treatment strategies of RTH and TSH-oma are apparently different, thus identifying the difference between RTH and TSH-oma is of great significance for the diagnosis and treatment of SITSH. CASE DESCRIPTION: A 62-year-old man with a state of elevated thyroid hormones and inappropriate elevated serum TSH level was hospitalized in 2016. Results of the pituitary enhanced magnetic resonance imaging and the somatostatin test respectively demonstrated a space-occupying lesion of pituitary and an elevated serum sex hormone binding globulin (SHBG) and inhibited TSH secretion, which indicated the occurrence of TSH-oma. In 2019, a 23-year-old girl with a state of elevated thyroid hormones and inappropriate normal serum TSH was hospitalized. Interestingly, whole exome sequencing detection suggested a pathogenic mutation in thyroid hormone receptor β (THRB) gene, which has been shown to be associated with RTH. CONCLUSIONS: The difference between TSH-oma and RTH ought to be clarified for their accurate diagnose and treatment. The clinical experiences of the two cases reported here suggest that more detail information such as family medical history, serum SHBG level, and THRB gene test is helpful for the diagnose and treatment of TSH-oma and RTH. Additionally, we also summarized the identification points, diagnosis process, and treatment strategies for these two rare diseases.
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http://dx.doi.org/10.1002/brb3.2081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8119795PMC
May 2021

Poor outcomes of delirium in the intensive care units are amplified by increasing age: A retrospective cohort study.

World J Emerg Med 2021 ;12(2):117-123

Nursing Department, School of Medicine, Zhejiang University, Hangzhou 310058, China.

Background: Delirium in patients in intensive care units (ICUs) is an acute disturbance and fluctuation of cognition and consciousness. Though increasing age has been found to be related to ICU delirium, there is limited evidence of the effect of age on delirium outcomes. The aim of this study is to investigate the relationship between age categories and outcomes among ICU delirium patients.

Methods: Data were extracted from the electronic ICU (eICU) Collaborative Research Database with records from 3,931 patients with delirium. Patients were classified into non-aged (<65 years), young-old (65-74 years), middle-old (75-84 years), and very-old (≥85 years) groups. A Cox regression model was built to examine the role of age in death in ICU and in hospital after controlling covariates.

Results: The sample included 1,667 (42.4%) non-aged, 891 (22.7%) young-old, 848 (21.6%) middle-old, and 525 (13.3%) very-old patients. The ICU mortality rate was 8.3% and the hospital mortality rate was 15.4%. Compared with the non-aged group, the elderly patients (≥65 yeras) had higher mortality at ICU discharge ( =13.726, =0.001) and hospital discharge ( =56.347, <0.001). The Cox regression analysis showed that age was an independent risk factor for death at ICU discharge (hazard ratio []=1.502, 1.675, 1.840, 95% confidence interval [] 1.138-1.983, 1.250-2.244, 1.260-2.687; =0.004, 0.001, 0.002 for the young-, middle- and very-old group, respectively) as well as death at hospital discharge (=1.801, 2.036, 2.642, 95% 1.454-2.230, 1.638-2.530, 2.047-3.409; all <0.001).

Conclusions: The risks of death in the ICU and hospital increase with age among delirious patients.
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http://dx.doi.org/10.5847/wjem.j.1920-8642.2021.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947563PMC
January 2021

Characterization of autoantibodies and cytokines related to cutaneous lupus erythematosus.

Lupus 2021 Feb 22;30(2):315-319. Epub 2020 Oct 22.

Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Objective: To investigate the profiles of anti-RPLP0, anti-galectin3 antibodies, interferon-α (IFN-α), interferon-λ1(IFN-λ1) and interleukin-17A/F(IL-17A/F) in the subtypes of cutaneous lupus erythematosus (CLE) including acute CLE (ACLE), subacute CLE (SCLE) and discoid lupus erythematosus (DLE).

Methods: Serum levels of autoantibodies and cytokines were determined by enzyme-linked immunoabsorbent assay (ELISA). Lupus lesions were evaluated by cutaneous lupus erythematosus disease area and severity index (CLASI).

Results: Serum anti-RPLP0, anti-galectin3 antibodies and IFN-λ1 were higher in systemic lupus erythematosus (SLE) patients with skin lesions than those without skin lesions, compared to healthy controls. IFN-α, IL-17A and IL-17F was elevated in all patients regardless of skin lesions. The two antibodies, IFN-α and IL-17A were positively correlated with the CLASI score in all patients with CLE. In addition, serum IL-17A was positively correlated to the CLASI score of ACLE, SCLE and DLE, while anti-RPLP0 and anti-galectin3 antibodies were only correlated to the score of SCLE and IL-17F to DLE.

Conclusion: Serum anti-RPLP0, anti-galectin3 antibodies, IFN-α, IFN-λ1 and IL-17A/F are associated with the occurrence of lupus skin lesions regardless of the systemic complications, whereas the profiles of these inflammatory mediators vary with the subtypes of lupus skin lesions.
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http://dx.doi.org/10.1177/0961203320967759DOI Listing
February 2021

Death and do-not-resuscitate order in the emergency department: A single-center three-year retrospective study in the Chinese mainland.

World J Emerg Med 2020 ;11(4):231-237

Department of Nursing, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.

Background: Consenting to do-not-resuscitate (DNR) orders is an important and complex medical decision-making process in the treatment of patients at the end-of-life in emergency departments (EDs). The DNR decision in EDs has not been extensively studied, especially in the Chinese mainland.

Methods: This retrospective chart study of all deceased patients in the ED of a university hospital was conducted from January 2017 to December 2019. The patients with out-of-hospital cardiac arrest were excluded.

Results: There were 214 patients' deaths in the ED in the three years. Among them, 132 patients were included in this study, whereas 82 with out-of-hospital cardiac arrest were excluded. There were 99 (75.0%) patients' deaths after a DNR order medical decision, 64 (64.6%) patients signed the orders within 24 hours of the ED admission, 68 (68.7%) patients died within 24 hours after signing it, and 97 (98.0%) patients had DNR signed by the family surrogates. Multivariate analysis showed that four independent factors influenced the family surrogates' decisions to sign the DNR orders: lack of referral (odds ratio [OR] 0.157, 95% confidence interval [CI] 0.047-0.529, =0.003), ED length of stay (ED LOS) ≥72 hours ( 5.889, 95% 1.290-26.885, =0.022), acute myocardial infarction (AMI) ( 0.017, 95% 0.001-0.279, =0.004), and tracheal intubation ( 0.028, 95% 0.007-0.120, <0.001).

Conclusions: In the Chinese mainland, the proportion of patients consenting for DNR order is lower than that of developed countries. The decision to sign DNR orders is mainly affected by referral, ED LOS, AMI, and trachea intubation.
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http://dx.doi.org/10.5847/wjem.j.1920-8642.2020.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7517397PMC
January 2020

A Potential Predictive Biomarker for Miller/Payne Grading: PD-L1 Expression before Neoadjuvant Chemotherapy in Breast Cancer.

Oncol Res Treat 2020 21;43(11):573-583. Epub 2020 Sep 21.

Department of Pathology, Weifang People's Hospital, Weifang, China.

Background And Objective: The aim of this study was to investigate the value of programmed death ligand 1 (PD-L1) expression as a predictive biomarker for Miller/Payne grading before neoadjuvant chemotherapy (NACT) in breast cancer.

Patients And Methods: The expression of PD-L1 in pretreatment biopsies of breast cancer was assessed by immunohistochemistry in tissue microarrays. The results were analyzed using SPSS 22.0 statistical software.

Results: Of 53 female patients, 10 (18.9%) patients had a grade 5 (G5) response, and 12 (22.6%) patients showed PD-L1 expression, including 7 (13.2%) patients with staining in tumor cells (TCs) and 8 (15.1%) patients with staining in peritumoral lymphocytes (PTLCs). Logistic regression analysis revealed that G5 response to NACT was significantly associated with TCs or PTLCs PD-L1 positivity, whether with univariate analysis (TCs PD-L1: p = 0.00, OR 20.50, 95% CI 3.11-134.94; PTLCs PD-L1: p = 0.02, OR 6.50, 95% CI 1.27-33.20) or with multivariate analysis (TCs PD-L1: p = 0.00, OR 42.23, 95% CI 3.36-530.90; PTLCs PD-L1: p = 0.02, OR 9.07, 95% CI 1.37-60.02). The same trend was found in the luminal subgroup analysis (TCs PD-L1: p = 0.02, OR 23.43, 95% CI 1.66-331.58; PTLCs PD-L1: p = 0.01, OR 47.89, 95% CI 2.47-927.41).

Conclusion: G5 response to NACT in breast cancer was significantly associated with TCs or PTLCs PD-L1-positive expression in pretreatment biopsies; it can be expected that PD-L1 will become a new independent biomarker of response to NACT in breast cancer.
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http://dx.doi.org/10.1159/000508139DOI Listing
March 2021

Observation of the Sedative Effect of Dexmedetomidine Combined With Midazolam Nasal Drops Before a Pediatric Craniocerebral MRI.

J Craniofac Surg 2020 Sep;31(6):1796-1799

Department of Pediatrics, Second Affiliated Hospital of Army Medical University, Chongqing, China.

Objective: This study aimed to investigate the sedative effect of dexmedetomidine combined with midazolam nasal drops before a pediatric craniocerebral magnetic resonance imaging (MRI).

Methods: Eighty children who needed an MRI examination were enrolled in the present study and randomly divided into 2 groups: the observation group (dexmedetomidine combined with midazolam nasal drops) and the control group. After the children were given the medication, their heart rate, blood oxygen saturation (SpO2), and respiratory rate were continuously monitored and the adverse reactions such as nausea and vomiting, cough, restlessness, heart rate slowdown, and respiratory depression were observed.

Results: The difference in the onset time between the 2 groups was not statistically significant (P > 0.05), but the duration was significantly longer in the observation group than in the control group (P < 0.01) and the examination success rate were significantly higher in the observation group than in the control group (P < 0.05).

Conclusion: The protocol of 3 μg/kg of a dexmedetomidine injection combined with 0.3 mg/kg of midazolam nasal drops is safe, easy to operate, and has a high success rate, which is worthy of clinical promotion.
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http://dx.doi.org/10.1097/SCS.0000000000006657DOI Listing
September 2020

The diagnostic benefit of antibodies against ribosomal proteins in systemic lupus erythematosus.

Adv Rheumatol 2020 08 28;60(1):45. Epub 2020 Aug 28.

Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang Rd W, Guangzhou, 510120, China.

Background: Anti-ribosomal P (anti-Rib-P) antibody is a specific serological marker for systemic lupus erythematosus (SLE) and routinely tested by targeting the common epitope of three ribosomal proteins of P0, P1 and P2. This study aimed to investigate if testing antibodies against individual ribosomal protein, but not the common epitope, is required to achieve the best diagnostic benefit in SLE.

Methods: The study included 82 patients with SLE and 22 healthy donors. Serum antibodies were determined by ELISA and immunoblot.

Results: The prevalence of each antibody determined by ELISA was 35.4% (anti-Rib-P), 45.1% (anti-Rib-P0), 32.9% (anti-Rib-P1) and 40.2% (anti-Rib-P2) at 99% specificity, respectively. Of 53 patients with negative anti-Rib-P antibody, 21 (39.6%) were positive for anti-Rib-P0, 9 (17.0%) for anti-Rib-P1 and 12 (22.6%) for anti-Rib-P2 antibody. The positive rate of anti-Rib-P antibody detected by ELISA was close to the results by immunoblot (33.4%). Patients with any of these antibodies were featured by higher disease activity and prevalence of skin rashes than those with negative antibodies. Moreover, each antibody was particularly related to some clinical and laboratory disorders. The distribution of subclasses of IgG1-4 was varied with each antibody. Anti-Rib-P0 IgG1 and IgG3 were strongly correlated with disease activity and lower serum complement components 3 and 4.

Conclusions: Anti-Rib-P antibody is not adequate to predict the existence of antibodies against ribosomal P0, P1 and P2 protein. The examination of antibodies against each ribosomal protein is required to achieve additional diagnostic benefit and to evaluate the association with clinical and serological disorders as well.
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http://dx.doi.org/10.1186/s42358-020-00148-2DOI Listing
August 2020

[Clinical effect of functional chewing training in treatment of oral motor dysfunction in children with cerebral palsy: a prospective randomized controlled clinical trial].

Zhongguo Dang Dai Er Ke Za Zhi 2020 Jun;22(6):567-572

Department of Pediatrics, Second Affiliated Hospital, Army Medical University, Chongqing 400037, China.

Objective: To study the effect of functional chewing training (FuCT) on masticatory function, the severity of tongue thrust, and the severity and frequency of drooling in children with cerebral palsy.

Methods: A prospective study was performed for 48 children who were diagnosed with oral motor dysfunction from January 2019 to January 2020, and they were randomly divided into an FuCT group and an oral motor training group, with 24 children in each group. Both groups received FuCT or oral motor training for 12 weeks, and then they were evaluated in terms of the changes in the masticatory function, the severity of tongue thrust, and the severity and frequency of drooling.

Results: There were no significant differences between the two groups in the masticatory function, the severity of tongue thrust, and the severity and frequency of drooling before treatment (P>0.05). After the 12-week training, the FuCT group showed significant improvements in the masticatory function and the severity of tongue thrust and drooling (P<0.05), but with no improvement in the frequency of drooling (P>0.05), while the oral motor training group had no improvements in the masticatory function, the severity of tongue thrust, and the severity and frequency of drooling (P>0.05). After the 12-week training, the FuCT group had more significantly improvements in the severity of tongue thrust and the severity and frequency of drooling than the oral motor training group (P<0.05).

Conclusions: FuCT can effectively improve the masticatory function, the severity of tongue thrust, and the severity and frequency of drooling in children with cerebral palsy.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390224PMC
June 2020

Sorting Liquid Droplets by Surface Tension Using Devices with Quasi-Superamphiphobic Coatings.

Polymers (Basel) 2020 Apr 4;12(4). Epub 2020 Apr 4.

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China.

Any solid surface with homogenous or varying surface energy can spontaneously show variable wettability to liquid droplets with different or identical surface tensions. Here, we studied a glass slide sprayed with a quasi-superamphiphobic coating consisting of a hexane suspension of perfluorosilane-coated nanoparticles. Four areas on the glass slide with a total length of 7.5 cm were precisely tuned via ultraviolet (UV) irradiation, and droplets with surface tensions of 72.1-33.9 mN m were categorized at a tilting angle of 3°. Then, we fabricated a U-shaped device sprayed with the same coating and used it to sort the droplets more finely by rolling them in the guide groove of the device to measure their total rolling time and distance. We found a correlation between ethanol content/surface tension and rolling time/distance, so we used the same device to estimate the alcoholic strength of Chinese liquors and to predict the surface tension of ethanol aqueous solutions.
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http://dx.doi.org/10.3390/polym12040820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240524PMC
April 2020

Age-wise trends in alkaline phosphatase activity in 167,625 Chinese children aged 0-18 years.

Clin Biochem 2020 May 3;79:34-40. Epub 2020 Mar 3.

Department of Pediatrics, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, PR China. Electronic address:

Objective: Alkaline phosphatase (ALP) serves as a biomarker for diagnosing several types of diseases in adults; nonetheless, its use is restricted in children because of changes in ALP activity during different physiological phases. The present study aimed to investigate ALP activity and its dynamics in children of different ages to establish the reference values for ALP activity in children.

Methods: Total 167,625 samples of children aged 0-18 years were enrolled in this study. ALP activity was measured using the 4-nitrophenyl-1-phosphate disodium salt (4-NPP)-2-amino-2-methyl-1-propanol (AMP) method with an automatic biochemical analyzer. Patients with known diagnoses that may affect ALP activity were excluded. A percentile curve was plotted using MATLAB software, and the curve was fitted using the skewness-median-coefficient of variation (LMS) method.

Results: ALP activity reached the highest peak at 12-13 years of age and then gradually decreased to the lowest peak at 18-19 years of age in boys, whereas it reached the highest at 10-11 years and then gradually reduced to the lowest at 17-18 years in girls. Furthermore, the highest peak of ALP activity appeared substantially earlier in children of either sex in China than in those in Germany.

Conclusions: We showed the dynamics of ALP activity in both boys and girls between the ages of 0 and 18 years in China and compared the difference in ALP activity between children in China and Germany. Our findings provide a reference for clinicians.
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http://dx.doi.org/10.1016/j.clinbiochem.2020.03.001DOI Listing
May 2020

Comparable survival outcome between transplantation from haploidentical donor and matched related donor or unrelated donor for severe aplastic anemia patients aged 40 years and older: A retrospective multicenter cohort study.

Clin Transplant 2020 03 20;34(3):e13810. Epub 2020 Feb 20.

Peking University Institute of Haematology, National Clinical Research Centre for Hematologic Disease, Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation, Peking University People's Hospital, Beijing, China.

This retrospective multicenter cohort study aimed to compare the outcome of haploidentical hematopoietic stem cell transplantation (HID-HSCT) with matched sibling donor (MSD) and unrelated donor (URD) transplantation in severe aplastic anemia (SAA) patients 40 years of age and older. With a median follow-up time of 17.6 months, 85 consecutive patients were enrolled in the study, and the median patient age was 45 years (40, 58). The cumulative engraftment rates of neutrophil and platelet were 98.8 ± 0.0% and 92.9 ± 0.1%. The cumulative incidences of Grade 2-4 acute graft-versus-host disease (aGvHD) and chronic graft-versus-host disease (cGvHD) at 3 years were 14.1 ± 0.1% and 17.3 ± 0.2%. The 3-year estimated overall survival (OS) and failure-free survival (FFS) were 91.2 ± 3.2% and 89.7 ± 3.5%. In multivariate analysis, the only factor associated with inferior survival was an ECOG score ≥2. HID-HSCT was associated with a higher incidence of GvHD, but the difference of 3-year estimated OS between HID group and the other two cohorts was not significant (86.7 ± 6.4% for HID vs 92.1% ± 4.4% for MSD and 100% for URD, P = .481). HID-HSCT might be a feasible alternative option for selected SAA patients aged 40 years and older without a matched donor.
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http://dx.doi.org/10.1111/ctr.13810DOI Listing
March 2020

The interaction of an amorphous metal-organic cage-based solid (aMOC) with miRNA/DNA and its application on a quartz crystal microbalance (QCM) sensor.

Chem Commun (Camb) 2020 Jan 12;56(4):591-594. Epub 2019 Dec 12.

School of Chemistry, South China Normal University, Guangzhou, 510006, China. zhengsr-scnu.edu.cn wgzhang-scnu.edu.cn.

The interaction between an aMOC and miRNA/DNA is studied and the use of a signal probe DNA (spDNA)@aMOC complex as an effective amplifier in a QCM sensor to detect miRNA is developed. The signal can be significantly enhanced, which leads to improved performance when detecting and distinguishing miRNAs.
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http://dx.doi.org/10.1039/c9cc08014gDOI Listing
January 2020

Blockade of angiotensin-converting enzyme or tumor necrosis factor-α reverses maternal high-fat diet-induced sensitization of angiotensin II hypertension in male rat offspring.

Am J Physiol Regul Integr Comp Physiol 2020 02 20;318(2):R351-R359. Epub 2019 Nov 20.

Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa.

Maternal high-fat diet (HFD) is associated with metabolic syndrome and cardiovascular diseases in adult offspring. Our previous study demonstrated that maternal HFD enhances pressor responses to ANG II or a proinflammatory cytokine (PIC), which is associated with increased expression of brain renin-angiotensin system (RAS) components and PICs in adult offspring. The present study further investigated whether inhibition of angiotensin-converting enzyme (ACE) or tumor necrosis factor-α (TNF-α) blocks sensitization of ANG II hypertension in offspring of HFD dams. All offspring were bred from dams with normal fat diet (NFD) or HFD starting two weeks before mating and maintained until weaning of the offspring. Then the weaned offspring were treated with an ACE inhibitor (captopril) or a TNF-α inhibitor (pentoxifylline) in the drinking water through the end of testing with a slow-pressor dose of ANG II. RT-PCR analyses of the lamina terminalis and paraventricular nucleus revealed upregulation of mRNA expression of several RAS components and PICs in male offspring of HFD dams when compared with age-matched offspring of NFD dams. The enhanced gene expression was attenuated by blockade of either RAS or PICs. Likewise, ANG II administration produced an augmented pressor response in offspring of HFD dams. This was abolished by either ACE or TNF-α inhibitor. Taken together, this study provides mechanistic evidence and a therapeutic strategy that systemic inhibition of the RAS and PICs can block maternal HFD-induced sensitization of ANG II hypertension, which is associated with attenuation of brain RAS and PIC expression in offspring.
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http://dx.doi.org/10.1152/ajpregu.00200.2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052597PMC
February 2020

Preparation, characterization and antimicrobial activity of inclusion complexes of Hott. essential oil in β-cyclodextrins.

Pharmazie 2019 10;74(10):590-594

Inclusion complexes of essential oils with cyclodextrins are an effective way to improve stability and solubility, and turn liquid materials into easy to handle powders. In this work, an essential oil of Hott. (MFEO), already used in the food and cosmetics industries, was formulated with beta-cyclodextrins (β-CD) using a co-precipitation method. The orthogonal array scheme was adapted for the optimization of preparation process. DSC and FT-IR spectroscopy analysis indicated the successful formation of MFEO/β-CD inclusion complexes, which improved the thermal stability of MFEO. Furthermore, comparing the antimicrobial activity of MFEO/β-CD inclusion complexes and free essential oil against , , , , yeast and , it was found that the antimicrobial effect was enhanced after the formation of inclusion complexes. This study demonstrates the potential for the use of MFEO/β-CD inclusion complexes in the treatment of bacterial infection.
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http://dx.doi.org/10.1691/ph.2019.9061DOI Listing
October 2019

Synbiotics for prevention of ventilator-associated pneumonia: a probiotics strain-specific network meta-analysis.

J Int Med Res 2019 Nov 3;47(11):5349-5374. Epub 2019 Oct 3.

Department of Pediatric, Xinqiao Hospital, Army Medical University, Chongqing, China.

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http://dx.doi.org/10.1177/0300060519876753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862886PMC
November 2019

Expression profile analysis of prognostic long non-coding RNA in adult acute myeloid leukemia by weighted gene co-expression network analysis (WGCNA).

J Cancer 2019 19;10(19):4707-4718. Epub 2019 Aug 19.

Department of Hematology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China.

Long non-coding RNAs (lncRNAs), which are over 200 nt in length, have a key role in tumorigenesis and disease progression. To explore the role of prognostic lncRNAs in adult acute myeloid leukemia (AML), the expression profiles of lncRNAs and mRNAs in AML were analyzed. The RNAseq data of 167 adult AML patients and the corresponding clinical information were downloaded from The Cancer Genome Atlas (TCGA), which is a publicly available database. The RPKM values of the RNAseq data were subjected to weighted gene co-expression network analysis (WGCNA) in modularization. We identified survival specific lncRNAs and mRNAs, which were divided into modules by coexpression analysis. The lncRNAs were mainly annotated into "Fc gamma R-mediated phagocytosis". The hub lncRNA and co-expressed mRNAs were further selected for analysis of risk stratification. LncRNA-LOC646762 may contribute to AML through the "endocytosis" signaling pathway. Finally, the expression levels of LOC646762 and co-expressed CCND3, CBR1, C10orf54, CD97 and BLOC1S1 in the adult AML patients and healthy volunteers were validated by qRT-PCR, and then their roles in prognosis and risk stratification were identified. Prognostic lncRNA-LOC646762, which may contribute to AML through the "endocytosis" signaling pathway, may act as a biomarker for predicting the survival of adult AML patients, as well as for risk stratification.
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http://dx.doi.org/10.7150/jca.31234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746144PMC
August 2019

Can a one-on-one mentorship program reduce the turnover rate of new graduate nurses in China? A longitudinal study.

Nurse Educ Pract 2019 Oct 19;40:102616. Epub 2019 Aug 19.

Nursing Department, The Second Affiliated Hospital of Zhejiang University School of Medicine, No. 88 Jiefang Road, 310009, Hangzhou, Zhejiang Province, China. Electronic address:

Nursing graduates experience "reality shock" upon entering the workplace as well as face challenges and stress during their transition from nursing student to qualified nurse. The high turnover rate of new graduate nurses not only increases an organization's human resources costs but also results in a shortage of nurses. In particular, a poor experience during the transition from nursing student to qualified nurse can lead to significant turnover. A three-year longitudinal study was conducted to assess the effectiveness of one-on-one mentorship program in reducing the turnover rate of nurses in China. A total of 199 new graduate nurses, recruited in 2013, were considered the control group and received a basic preceptorship, and 239 nurses in 2014 were considered the experimental group, for which a one-on-one mentorship program was implemented. Propensity-score-matching analysis was conducted to adjust the baseline of the two groups, and survival analysis was performed to compare the two groups. The findings showed that the turnover rates for the experimental group were 3.77%, 3.48%, and 8.11% as compared to 14.07%, 9.36%, and 14.19% for the control group at the end of the first three years, respectively. The survival curves of the two groups were significantly different (p < 0.001). The turnover rate for the first year in the experimental group was significantly lower than that for the control group, but the rates in the second and third years were not different. The results indicate that a one-on-one mentorship program is beneficial for the retention of new graduate nurses, particularly during the first year.
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http://dx.doi.org/10.1016/j.nepr.2019.08.010DOI Listing
October 2019

[Infection factors associated with neurodysplasia in early and moderately preterm infants].

Zhongguo Dang Dai Er Ke Za Zhi 2019 Sep;21(9):856-860

Department of Pediatrics, Second Affiliated Hospital of Army Medical University, Chongqing 400037, China.

Objective: To investigate the infection factors associated with neurodysplasia in early and moderately preterm infants at a corrected age of 18 months.

Methods: The preterm infants with a gestational age of 28 weeks to <34 weeks who were admitted to the neonatal intensive care unit and followed up at the outpatient service for high-risk preterm infants from June 2015 to December 2018 were enrolled as subjects. At a corrected age of 18 months, the revised Bayley Scales of Infant Development was used to evaluate neurodevelopment. Univariate and multivariate logistic regression analyses were used to investigate the infection factors affecting neurodevelopment.

Results: A total of 138 early or moderately preterm infants were enrolled, among whom 59 had neurodysplasia at a corrected age of 18 months. The univariate logistic regression analysis showed that neurodysplasia was associated with late-onset infection, positive blood culture, and other systemic infections (P<0.05). The multivariate logistic regression analysis showed that late-onset infection was an independent risk factor for neurodysplasia (OR=1.510, 95%CI: 1.133-3.600, P<0.05).

Conclusions: Late-onset infection can increase the risk of neurodysplasia in early and moderately preterm infants.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390245PMC
September 2019

Who is the best haploidentical donor for acquired severe aplastic anemia? Experience from a multicenter study.

J Hematol Oncol 2019 09 2;12(1):87. Epub 2019 Sep 2.

National Clinical Research Center for Hematologic Disease, Peking University Institute of Hematology, Peking University People's Hospital, Beijing, China.

Background: Haploidentical transplantation has been proposed as an effective treatment for severe aplastic anemia (SAA). The majority of patients have more than one HLA-haploidentical donor. Herein, we compared the outcomes between different donor-recipient relationships for optimal haploidentical donor selection in acquired SAA.

Methods: We conducted a multicenter study based on a registered database of 392 patients with SAA treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT) between 2006 and 2018. In total, 223 patients received grafts from father donors, 47 from mother donors, 91 from siblings, 29 from children, and 2 from collateral donors.

Results: Of the 381 patients who survived more than 28 days, 379 (99.5%) recipients were engrafted. The 2-year overall survival (OS) was 86.6 ± 2.5%, 87.1 ± 4.9%, 84.3 ± 3.9%, and 92.2 ± 5.1% for recipients of father, mother, sibling, and child grafts, respectively, (P = 0.706). The 2-year failure-free survival (FFS) was 82.8 ± 2.7%, 86.7 ± 5.1%, 80.8 ± 4.2%, and 92.5 ± 5.1% for recipients of father, mother, sibling, and child grafts, respectively, (P = 0.508). There was no difference in the incidence of either acute or chronic graft-versus-host disease (GVHD) among the different donor sources in multivariate analyses. There were also no differences in the OS or FFS among the different donor sources in the Cox regression analysis. However, OS was significantly better in the patients with a shorter history of aplastic anemia (< 12 months), better performance status (ECOG scores 0-1), or moderate graft mononuclear cell (MNC) counts (6-10 × 10/kg), and in female recipients with male donors. The FFS was also higher in patients with a shorter history of aplastic anemia (< 12 months) and better performance status (ECOG scores 0-1).

Conclusions: Fathers, mothers, siblings, and children are all suitable haploidentical donors for patients with SAA.
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http://dx.doi.org/10.1186/s13045-019-0775-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719398PMC
September 2019

Simultaneous determination of six components in commercial Roukou Wuwei pills using ultra-high-performance liquid chromatography with diode-array detector.

Biomed Chromatogr 2019 Dec 2;33(12):e4677. Epub 2019 Sep 2.

Department of Pharmacy, Hebei North University, Zhangjiakou, P.R. China.

An efficient ultra-performance liquid chromatography with diode-array detector method was established for simultaneous determination of six active components in Roukou Wuwei pills, namely gallic acid, piperine, costundide, dehydrocostus lactone, isoalantolactone and alantolactone. Chromatographic separation of six components was successfully achieved on an Waters BEH C column (50 × 2.1 mm, 1.7 μm) with a mobile phase composed of acetonitrile and water using a gradient elution. Gallic acid and piperine were detected at 270 nm and 343 nm, respectively; while costundide, dehydrocostus lactone, isoalantolactone and alantolactone were simultaneously measured at 225 nm. All six calibration curves showed good linearity (R  ≥ 0.9994) between the peak area of each component and corresponding concentration. Relative standard deviations for inter- and intra-day precisions were <0.45 and 0.77%, respectively. The mean recovery rates ranged from 96.72 to 102.2% with relative standard deviations <2.07%. The developed method was validated in terms of linearity, precision and accuracy and then successfully applied for the quality control of commercial Roukou Wuwei samples.
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http://dx.doi.org/10.1002/bmc.4677DOI Listing
December 2019

Efficacy of uric acid-lowering therapy on hypercholesterolemia and hypertriglyceridemia in gouty patients.

Int J Rheum Dis 2019 Aug 17;22(8):1445-1451. Epub 2019 Jul 17.

Department of Rheumatology and Clinical Immunology, ZhuJiang Hospital, Southern Medical University, Guangzhou, China.

Aim: To investigate the effects on hypercholesterolemia and hypertriglyceridemia in gouty patients receiving uric acid-lowering therapy (UALT).

Methods: A retrospective study was performed from January 2015 to December 2017 in gouty patients receiving UALT. A total of 124 gouty patients with hypercholesterolemia or hypertriglyceridemia who were administered UALT were monitored. Of the 124 patients with gout, 52 were treated with febuxostat, 29 were treated with allopurinol, and 43 were treated with benzbromarone. Cholesterol and triglyceride levels were recorded and analyzed following treatment for 8-10 weeks.

Results: We compared the efficacy of febuxostat, allopurinol, and benzbromarone. All therapies mildly influenced serum cholesterol and triglyceride levels. Febuxostat significantly decreased cholesterol and triglyceride levels in patients who did not receive lipid-lowering therapy. Allopurinol and benzbromarone modestly decreased triglyceride levels, but cholesterol levels were unaffected.

Conclusion: Uric acid-lowering therapy benefits hyperlipidemia in gouty patients. Febuxostat effectively improved serum cholesterol and triglyceride levels compared to allopurinol and benzbromarone in patients with gout.
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http://dx.doi.org/10.1111/1756-185X.13652DOI Listing
August 2019

Blockade of Stellate Ganglion Remediates Hemorrhagic Shock-Induced Intestinal Barrier Dysfunction.

J Surg Res 2019 12 4;244:69-76. Epub 2019 Jul 4.

Institute of Microcirculation, Hebei North University, Hebei Zhangjiakou, PR China. Electronic address:

Background: Acute hemorrhage-induced excessive excitation of sympathetic-adrenal-medullary system (SAS) leads to gut hypoperfusion and barrier dysfunction, which is a critical event during hemorrhagic shock-induced multiple organ injury. Stellate ganglion blockade (SGB) has been widely used for suppression of sympathetic-adrenal-medullary system in the clinical practice. However, whether SGB improves intestinal barrier function after hemorrhagic shock remains unclear. Here, we hypothesized that the implementation of SGB restores intestinal barrier function and reduces gut injury.

Materials And Methods: Male rats received the SGB pretreatment and underwent hemorrhagic shock followed by resuscitation. The 96-h survival rate, intestinal permeability and morphology, D-lactic acid concentration and diamine oxidase activity in plasma, and expressions of F-actin, Claudin-1, and E-cadherin in intestinal tissues were observed.

Results: Pretreatment with SGB significantly enhances the 96-h survival rate in rats subjected to hemorrhagic shock (from 8.3% to 66.7%). Hemorrhagic shock reduced the coverage scale of intestinal mucus and intestinal villus width and height, enhanced the intestinal permeability to fluorescein isothiocyanate-dextran 4 and D-lactic acid concentration in plasma, and decreased the expressions of F-actin, Claudin-1, and E-Cadherin in intestinal tissue. These hemorrhagic shock-induced adverse effects were abolished by SGB treatment.

Conclusions: SGB treatment has a beneficial effect during hemorrhagic shock, which is associated with the improvement of intestine barrier function. SGB may be considered as a new therapeutic strategy for treatment of hemorrhagic shock.
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http://dx.doi.org/10.1016/j.jss.2019.06.007DOI Listing
December 2019

A novel synthesis of oleophylic FeO/polystyrene fibers by γ-Ray irradiation for the enhanced photocatalysis of 4-chlorophenol and 4-nitrophenol degradation.

J Hazard Mater 2019 11 21;379:120806. Epub 2019 Jun 21.

College of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang, 453000, China.

Photocatalytic degradation by efficient and easy recyclable semiconductor-catalysts is an ideal way to solve the environmental problem. A series of FeO/Polystyrene (FeO/PS) composite fibers with hydrophobic property were obtained by the electrospinning and γ-Ray irradiation methods. The γ-Ray irradiation treatment not only formed steady micro-nano construction of nanoparticles and fiber, but also reduced the hydroxyl group on FeO surface. The high photocatalytic efficiencies of FeO/PS fiber were discovered with the high content of 4-chlorophenol (4-CP) and 4-nitrophenol (4-NP), due to the synergetic effect of adsorption and degradation. The suitable adsorption capacity of FeO/PS could promote the utilization of the generated hydroxyl radical(OH) to directly oxidize the adsorbed pollutant molecules. Additionally, the photocatalytic activities for 4-CP and 4-NP still reached 80% and 75% in the 6 cycling and the composite fiber exhibited the good recyclability, which has the application development prospect for wastewater treatment. The mechanism of 4-CP and 4-NP decomposition was verified. Hence, the gained results could provide some insights into phenol degradation over the multifunctional and efficient catalyst.
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http://dx.doi.org/10.1016/j.jhazmat.2019.120806DOI Listing
November 2019

Facile Fabrication of Superhydrophobic Copper- Foam and Electrospinning Polystyrene Fiber for Combinational Oil⁻Water Separation.

Polymers (Basel) 2019 Jan 8;11(1). Epub 2019 Jan 8.

College of Chemistry and Molecular Engineering, Zhengzhou University, Henan 450001, China.

Membrane-based metal substrates with special surface wettability have been applied widely for oil/water separation. In this work, a series of copper foams with superhydrophobicity and superoleophilicity were chemically etched using 10 mg mL-1 FeCl3/HCl solution with consequent ultrasonication, followed by the subsequent modification of four sulfhydryl compounds. A water contact angle of 158° and a sliding angle lower than 5° were achieved for the copper foam modified using 10 mM n-octadecanethiol solution in ethanol. In addition, the interaction mechanism was initially investigated, indicating the coordination between copper atoms with vacant orbital and sulfur atoms with lone pair electrons. In addition, the polymeric fibers were electrospun through the dissolution of polystyrene in a good solvent of chlorobenzene, and a nonsolvent of dimethyl sulfoxide. Oil absorption and collection over the water surface were carried out by the miniature boat made out of copper foam, a string bag of as-spun PS fibers with high oil absorption capacity, or the porous boat embedded with the as-spun fibers, respectively. The findings might provide a simple and practical combinational method for the solution of oil spill.
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http://dx.doi.org/10.3390/polym11010097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402002PMC
January 2019
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