Yu-Jui Yvonne Wan

Yu-Jui Yvonne Wan

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Yu-Jui Yvonne Wan

Yu-Jui Yvonne Wan

Publications by authors named "Yu-Jui Yvonne Wan"

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inhibition reduces hepatic steatosis via FGF21 and FGFR1 induction.

JHEP Rep 2020 Apr 18;2(2):100093. Epub 2020 Feb 18.

Department of Pathology and Laboratory Medicine, University of California Davis Health, Sacramento, CA 95817, United States of America.

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http://dx.doi.org/10.1016/j.jhepr.2020.100093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078383PMC
April 2020

Short-Term Exposure to a Western Diet Induces Psoriasiform Dermatitis by Promoting Accumulation of IL-17A-Producing γδ T Cells.

J Invest Dermatol 2020 Feb 10. Epub 2020 Feb 10.

Department of Dermatology, University of California, Davis, Sacramento, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2020.01.020DOI Listing
February 2020

Diet-induced obesity exacerbates imiquimod-mediated psoriasiform dermatitis in anti-PD-1 antibody-treated mice: Implications for patients being treated with checkpoint inhibitors for cancer.

J Dermatol Sci 2020 Jan 24. Epub 2020 Jan 24.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dermatology, University of California, Davis, Sacramento, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2020.01.011DOI Listing
January 2020

Long-term Western diet intake leads to dysregulated bile acid signaling and dermatitis with Th2 and Th17 pathway features in mice.

J Dermatol Sci 2019 Jul 8;95(1):13-20. Epub 2019 Jun 8.

Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, 95817, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jdermsci.2019.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6991164PMC
July 2019

A Western Diet, but Not a High-Fat and Low-Sugar Diet, Predisposes Mice to Enhanced Susceptibility to Imiquimod-Induced Psoriasiform Dermatitis.

J Invest Dermatol 2019 06 17;139(6):1404-1407. Epub 2018 Dec 17.

Department of Dermatology, University of California, Davis, Sacramento, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.12.002DOI Listing
June 2019

Precision dietary supplementation based on personal gut microbiota.

Nat Rev Gastroenterol Hepatol 2019 Apr;16(4):204-206

Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA.

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http://dx.doi.org/10.1038/s41575-019-0108-zDOI Listing
April 2019

Functional Effects of Expression in Colon Cancer Metastasis.

Cancers (Basel) 2019 Apr 6;11(4). Epub 2019 Apr 6.

Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan.

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http://dx.doi.org/10.3390/cancers11040489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521310PMC
April 2019

RARβ acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells.

FASEB J 2019 02 25;33(2):2314-2326. Epub 2018 Sep 25.

Department of Medical Pathology and Laboratory Medicine, University of California, Davis Health System, Sacramento, California, USA.

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http://dx.doi.org/10.1096/fj.201801390RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338632PMC
February 2019

Obesity treatment by epigallocatechin-3-gallate-regulated bile acid signaling and its enriched Akkermansia muciniphila.

FASEB J 2018 Jun 8:fj201800370R. Epub 2018 Jun 8.

Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA.

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http://dx.doi.org/10.1096/fj.201800370RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219838PMC
June 2018

Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet-induced systemic inflammation, microglial activation, and reduced neuroplasticity.

FASEB J 2018 05 10;32(5):2866-2877. Epub 2018 Jan 10.

Department of Medical Pathology and Laboratory Medicine University of California, Davis, Sacramento, California, USA; and.

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http://dx.doi.org/10.1096/fj.201700984RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901391PMC
May 2018

Hepatic inflammation caused by dysregulated bile acid synthesis is reversible by butyrate supplementation.

J Pathol 2017 12 1;243(4):431-441. Epub 2017 Nov 1.

Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA.

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http://dx.doi.org/10.1002/path.4983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953422PMC
December 2017

PPARβ Regulates Liver Regeneration by Modulating Akt and E2f Signaling.

PLoS One 2013 18;8(6):e65644. Epub 2013 Jun 18.

Department of Medical Pathology and Laboratory Medicine, University of California, Sacramento, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0065644PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688817PMC
October 2017

Silencing of α-complex protein-2 reverses alcohol- and cytokine-induced fibrogenesis in hepatic stellate cells.

Liver Res 2017 Jun;1(1):70-79

Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.

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http://dx.doi.org/10.1016/j.livres.2017.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5613955PMC
June 2017

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration.

J Hepatol 2016 Mar 12;64(3):641-50. Epub 2016 Jan 12.

Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278150067
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http://dx.doi.org/10.1016/j.jhep.2015.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761311PMC
March 2016

Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases.

Transl Res 2016 Mar 6;169:67-79.e1-2. Epub 2015 Nov 6.

The Center for Growth, Metabolism and Aging, The Key Laboratory for Bio-Resource and Eco-Environment, College of Life Science, and The National Key Laboratory of Biotherapy, Sichuan University, Chengdu, China. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2015.10.008DOI Listing
March 2016

Association of Fusobacterium nucleatum infection with colorectal cancer in Chinese patients.

World J Gastroenterol 2016 Mar;22(11):3227-33

Yu-Yuan Li, Quan-Xing Ge, Jie Cao, Yong-Jian Zhou, Yan-Lei Du, Bo Shen, Yu-Qiang Nie, Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, Guangdong Province, China.

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http://www.wjgnet.com/1007-9327/full/v22/i11/3227.htm
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http://dx.doi.org/10.3748/wjg.v22.i11.3227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789998PMC
March 2016

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration.

Oncotarget 2016 Jan;7(2):1096-106

Department of Medical Pathology and Laboratory Medicine, University of California, Davis, Sacramento, CA, USA.

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http://dx.doi.org/10.18632/oncotarget.6665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811446PMC
January 2016

Implications of microbiota and bile acid in liver injury and regeneration.

J Hepatol 2015 Dec 7;63(6):1502-10. Epub 2015 Aug 7.

Department of Medical Pathology and Laboratory Medicine, University of California, Sacramento, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jhep.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654653PMC
December 2015

Hepatoma SK Hep-1 cells exhibit characteristics of oncogenic mesenchymal stem cells with highly metastatic capacity.

PLoS One 2014 22;9(10):e110744. Epub 2014 Oct 22.

Department of Internal Medicine, University of California Davis Medical Center, Sacramento, California, United States of America; Institute for Regenerative Cures, University of California Davis Medical Center, Sacramento, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110744PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206444PMC
July 2015

Genome-wide binding and transcriptome analysis of human farnesoid X receptor in primary human hepatocytes.

PLoS One 2014 8;9(9):e105930. Epub 2014 Sep 8.

Department of Pharmacology and Toxicology, School of Pharmacy, Rutgers University, Piscataway, New Jersey, United States of America; Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105930PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157742PMC
May 2015

MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor.

J Biol Chem 2015 Mar 17;290(10):6507-15. Epub 2015 Jan 17.

From the Department of Pathology and Laboratory Medicine, the University of California at Davis Medical Center, Sacramento, California 95817 and the Institute of Chinese Material Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203 China

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http://dx.doi.org/10.1074/jbc.M114.620369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4358284PMC
March 2015

Bile acids regulate nuclear receptor (Nur77) expression and intracellular location to control proliferation and apoptosis.

Mol Cancer Res 2015 Feb 17;13(2):281-92. Epub 2014 Sep 17.

Department of Medical Pathology and Laboratory Medicine, University of California, Davis Health Systems, Sacramento, California. Department of Gastroenterology, First Municipal's People Hospital of Guangzhou, Guangzhou Medical University, Guangzhou, China.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-14-0230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336821PMC
February 2015

Accelerated partial hepatectomy-induced liver cell proliferation is associated with liver injury in Nur77 knockout mice.

Am J Pathol 2014 Dec 7;184(12):3272-83. Epub 2014 Oct 7.

Department of Medical Pathology and Laboratory Medicine, University of California, Davis Health Systems, Sacramento, California; Department of Gastroenterology and Hepatology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China; Guangzhou Digestive Disease Center, Guangzhou, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029440140048
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http://dx.doi.org/10.1016/j.ajpath.2014.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258495PMC
December 2014

Bile acid dysregulation, gut dysbiosis, and gastrointestinal cancer.

Exp Biol Med (Maywood) 2014 Nov 20;239(11):1489-504. Epub 2014 Jun 20.

Department of Pathology and Laboratory Medicine, University of California at Davis Medical Center, Sacramento, CA 95831, USA

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http://dx.doi.org/10.1177/1535370214538743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357421PMC
November 2014

All-trans retinoic acid regulates hepatic bile acid homeostasis.

Biochem Pharmacol 2014 Oct 28;91(4):483-9. Epub 2014 Aug 28.

Institute of Chinese Material Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cai-Lun Road, Shanghai 201203, China; Department of Pathology and Laboratory Medicine, the University of California at Davis Medical Center, 4645, 2nd Avenue, Sacramento, CA 95817, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.08.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236914PMC
October 2014

Retinoic acid regulates cell cycle genes and accelerates normal mouse liver regeneration.

Biochem Pharmacol 2014 Sep 1;91(2):256-65. Epub 2014 Aug 1.

Department of Medical Pathology and Laboratory Medicine, 4645 2nd Ave, Research Building III, University of California, Davis Health Systems, Sacramento, CA 95817,United States of America. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00062952140039
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http://dx.doi.org/10.1016/j.bcp.2014.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236911PMC
September 2014

Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.

Am J Physiol Gastrointest Liver Physiol 2014 Jul 15;307(2):G205-18. Epub 2014 May 15.

Department of Pathology and Laboratory Medicine, University of California Davis Medical Center, Sacramento, California

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http://www.physiology.org/doi/10.1152/ajpgi.00105.2014
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http://dx.doi.org/10.1152/ajpgi.00105.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101682PMC
July 2014

The effect of miRNA-122 in regulating fat deposition in a cell line model.

J Cell Biochem 2014 May;115(5):839-46

Department of Gastroenterology and Hepatology, Guangzhou Institute of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, 510180, China.

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http://dx.doi.org/10.1002/jcb.24725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991241PMC
May 2014

Metabolomic and genomic evidence for compromised bile acid homeostasis by senecionine, a hepatotoxic pyrrolizidine alkaloid.

Chem Res Toxicol 2014 May 1;27(5):775-86. Epub 2014 Apr 1.

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine , 1200 Cailun Road, Shanghai 201203, China.

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http://dx.doi.org/10.1021/tx400451qDOI Listing
May 2014

Nutritional lipidomics: molecular metabolism, analytics, and diagnostics.

Mol Nutr Food Res 2013 Aug 1;57(8):1319-35. Epub 2013 Jul 1.

Foods for Health Institute, University of California, Davis, CA 95616, USA.

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http://dx.doi.org/10.1002/mnfr.201200808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3806310PMC
August 2013

The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling.

BMC Genomics 2013 Aug 28;14:575. Epub 2013 Aug 28.

Department of Medical Pathology and Laboratory Medicine, University of California, Davis Health Systems, Sacramento 95817, CA, USA.

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http://dx.doi.org/10.1186/1471-2164-14-575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3846674PMC
August 2013

Function annotation of hepatic retinoid x receptor α based on genome-wide DNA binding and transcriptome profiling.

PLoS One 2012 15;7(11):e50013. Epub 2012 Nov 15.

Department of Gastroenterology Hepatology, Guangzhou First Municipal People's Hospital, Guangzhou Medical College, Guangzhou, Guangdong Province, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0050013PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499475PMC
April 2013

Transcriptome profiling and genome-wide DNA binding define the differential role of fenretinide and all-trans RA in regulating the death and survival of human hepatocellular carcinoma Huh7 cells.

Biochem Pharmacol 2013 Apr 8;85(7):1007-17. Epub 2013 Feb 8.

Department of Medical Pathology and Laboratory Medicine, 4645 2nd Ave, Research Building III, University of California, Davis Health Systems, Sacramento, CA 95817, USA.

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http://dx.doi.org/10.1016/j.bcp.2013.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857153PMC
April 2013

NURBS: a database of experimental and predicted nuclear receptor binding sites of mouse.

Bioinformatics 2013 Jan 29;29(2):295-7. Epub 2012 Nov 29.

Applied Bioinformatics Laboratory, University of Kansas, Lawrence, KS 66047, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/bts693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546791PMC
January 2013

Evaluation of the protective effect of Rhei Radix et Rhizoma against α-naphthylisothiocyanate induced liver injury based on metabolic profile of bile acids.

J Ethnopharmacol 2012 Dec 8;144(3):599-604. Epub 2012 Oct 8.

MOE Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China.

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http://dx.doi.org/10.1016/j.jep.2012.09.049DOI Listing
December 2012

The C-681G polymorphism of the PPAR-γ gene is associated with susceptibility to non-alcoholic fatty liver disease.

Tohoku J Exp Med 2012 08;227(4):253-62

Department of Gastroenterology and Hepatology, Guangzhou Institute of Clinical Medicine, Guangzhou First Municipal People's Hospital, Guangzhou Medical College, Guangzhou, PR China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126502PMC
http://dx.doi.org/10.1620/tjem.227.253DOI Listing
August 2012

PCBP2 siRNA reverses the alcohol-induced pro-fibrogenic effects in hepatic stellate cells.

Pharm Res 2011 Dec 4;28(12):3058-68. Epub 2011 Jun 4.

Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.

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http://link.springer.com/10.1007/s11095-011-0475-9
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http://dx.doi.org/10.1007/s11095-011-0475-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970775PMC
December 2011

Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.

Antioxid Redox Signal 2011 Oct 13;15(8):2135-46. Epub 2011 Jun 13.

Innovative Drug Research Center for Metabolic and Inflammatory Disease, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea.

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http://dx.doi.org/10.1089/ars.2010.3834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468953PMC
October 2011

The interaction between HCV and nuclear receptor-mediated pathways.

Pharmacol Ther 2011 Oct 18;132(1):30-8. Epub 2011 May 18.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S016372581100116
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http://dx.doi.org/10.1016/j.pharmthera.2011.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3152951PMC
October 2011

Inhibition of Carrageenan-Induced Cutaneous Inflammation by PPAR Agonists Is Dependent on Hepatocyte-Specific Retinoid X ReceptorAlpha.

PPAR Res 2006 ;2006:96341

Department of Pharmacology, Toxicology & Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

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https://www.hindawi.com/journals/ppar/2006/096341/abs/
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http://dx.doi.org/10.1155/PPAR/2006/96341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1664714PMC
July 2011

ERK1/2 deactivation enhances cytoplasmic Nur77 expression level and improves the apoptotic effect of fenretinide in human liver cancer cells.

Biochem Pharmacol 2011 Apr 15;81(7):910-6. Epub 2011 Jan 15.

Department of Gastroenterology, Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

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http://linkinghub.elsevier.com/retrieve/pii/S000629521100038
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http://dx.doi.org/10.1016/j.bcp.2011.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059345PMC
April 2011

Enrichment of Nur77 mediated by retinoic acid receptor β leads to apoptosis of human hepatocellular carcinoma cells induced by fenretinide and histone deacetylase inhibitors.

Hepatology 2011 Mar 11;53(3):865-74. Epub 2011 Feb 11.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.

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http://doi.wiley.com/10.1002/hep.24101
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http://dx.doi.org/10.1002/hep.24101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077573PMC
March 2011

Retinoid pathway and cancer therapeutics.

Adv Drug Deliv Rev 2010 Oct 3;62(13):1285-98. Epub 2010 Aug 3.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0169409X1000146
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http://dx.doi.org/10.1016/j.addr.2010.07.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991380PMC
October 2010

The association of exon 3 VNTR polymorphism of the dopamine receptor D4 (DRD4) gene with alcoholism in Mexican Americans.

Psychiatry Res 2010 May 1;177(3):358-60. Epub 2010 Apr 1.

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1016/j.psychres.2010.02.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868944PMC
May 2010

Pathogenesis of alcoholic liver disease: the role of nuclear receptors.

Exp Biol Med (Maywood) 2010 May;235(5):547-60

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, Kansas 66160-7417, USA.

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http://journals.sagepub.com/doi/10.1258/ebm.2009.009249
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http://dx.doi.org/10.1258/ebm.2009.009249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908670PMC
May 2010

Induction and intracellular localization of Nur77 dictate fenretinide-induced apoptosis of human liver cancer cells.

Biochem Pharmacol 2010 Apr 11;79(7):948-54. Epub 2009 Nov 11.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1016/j.bcp.2009.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832928PMC
April 2010

The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury.

Lab Invest 2010 Feb 7;90(2):257-65. Epub 2009 Dec 7.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://www.nature.com/doifinder/10.1038/labinvest.2009.129
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http://dx.doi.org/10.1038/labinvest.2009.129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814901PMC
February 2010

Deregulation of growth factor, circadian clock, and cell cycle signaling in regenerating hepatocyte RXRalpha-deficient mouse livers.

Am J Pathol 2010 Feb 24;176(2):733-43. Epub 2009 Dec 24.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000294401060387
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http://dx.doi.org/10.2353/ajpath.2010.090524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808080PMC
February 2010

Retinoids activate RXR/CAR-mediated pathway and induce CYP3A.

Biochem Pharmacol 2010 Jan 15;79(2):270-6. Epub 2009 Aug 15.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Biomedical Research Center Building/KLSIC, 2146 W 39th Avenue, Kansas City, KS 66160, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000629520900692
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http://dx.doi.org/10.1016/j.bcp.2009.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2784018PMC
January 2010

Histone modification-mediated CYP2E1 gene expression and apoptosis of HepG2 cells.

Exp Biol Med (Maywood) 2010 Jan;235(1):32-9

Department of Gastroenterology Hepatology, First Municipal's People Hospital of Guangzhou, Guangzhou Medical College, Guangzhou 510180, China.

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http://dx.doi.org/10.1258/ebm.2009.009252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991239PMC
January 2010

The interaction of reward genes with environmental factors in contribution to alcoholism in mexican americans.

Alcohol Clin Exp Res 2009 Dec 17;33(12):2103-12. Epub 2009 Sep 17.

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, U.S.A.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017868PMC
December 2009

Retinoic Acid-mediated Nuclear Receptor Activation and Hepatocyte Proliferation.

J Exp Clin Med 2009 Dec;1(1):23-30

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, USA.

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http://dx.doi.org/10.1016/S1878-3317(09)60007-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5021315PMC
December 2009

Comparison of the population capacity of hematopoietic and mesenchymal stem cells in experimental colitis rat model.

Transplantation 2009 Jul;88(1):42-8

Department of Gastroenterology, Guangzhou Institute of Clinical Medicine, First Municipal People's Hospital of Guangzhou, Guangzhou Medical College, Guangzhou, People's Republic of China.

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http://dx.doi.org/10.1097/TP.0b013e3181a9f0a7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991233PMC
July 2009

Gender disparity of hepatic lipid homoeostasis regulated by the circadian clock.

J Biochem 2009 May 27;145(5):609-23. Epub 2009 Jan 27.

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1093/jb/mvp018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917062PMC
May 2009

Mechanisms of resistance of hepatocyte retinoid X receptor alpha-null mice to WY-14,643-induced hepatocyte proliferation and cholestasis.

J Biol Chem 2009 Apr 27;284(14):9321-30. Epub 2009 Jan 27.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.

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http://dx.doi.org/10.1074/jbc.M808861200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666584PMC
April 2009

Hepatocyte RXR alpha deletion in mice leads to inhibition of angiogenesis.

Genes Nutr 2009 Mar 18;4(1):69-72. Epub 2009 Feb 18.

Department of Clinical Biochemistry, Jagiellonian University Medical College, Kopernika 15a Street, 31-501, Cracow, Poland,

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http://dx.doi.org/10.1007/s12263-009-0111-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654051PMC
March 2009

Pharmacogenomic strategy for individualizing antidepressant therapy.

Dialogues Clin Neurosci 2008 ;10(4):401-8

Division of Mental Health and Substance Abuse Research, National Health Research Institutes, Taipei, Taiwan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181891PMC
February 2009

Hepatic effects of a methionine-choline-deficient diet in hepatocyte RXRalpha-null mice.

Toxicol Appl Pharmacol 2009 Jan 8;234(2):166-78. Epub 2008 Oct 8.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656443PMC
January 2009

Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin.

Biochem Pharmacol 2009 Jan 15;77(2):238-47. Epub 2008 Oct 15.

Department of Biomedical and Pharmaceutical Sciences, Center for Pharmacogenomics and Molecular Therapy, University of Rhode Island Kingston, Kingston, RI 02881, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2671154PMC
January 2009

The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet.

Dig Dis Sci 2008 Oct 26;53(10):2761-74. Epub 2008 Feb 26.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://link.springer.com/10.1007/s10620-007-0193-7
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991247PMC
October 2008

Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner.

BMC Genomics 2008 Aug 28;9:403. Epub 2008 Aug 28.

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66103, USA.

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http://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2547858PMC
August 2008

Retinoids induce cytochrome P450 3A4 through RXR/VDR-mediated pathway.

Biochem Pharmacol 2008 Jun 6;75(11):2204-13. Epub 2008 Mar 6.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 2146 W 39th Avenue, Kansas City, KS 66160, United States.

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http://dx.doi.org/10.1016/j.bcp.2008.02.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742682PMC
June 2008

Nuclear receptors and inflammatory diseases.

Exp Biol Med (Maywood) 2008 May 28;233(5):496-506. Epub 2008 Mar 28.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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http://journals.sagepub.com/doi/10.3181/0708-MR-231
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991236PMC
May 2008

Pregnane X receptor is essential for normal progression of liver regeneration.

Hepatology 2008 Apr;47(4):1277-87

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA.

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April 2008

Hepatocyte retinoid X receptor alpha-dependent regulation of lipid homeostasis and inflammatory cytokine expression contributes to alcohol-induced liver injury.

J Pharmacol Exp Ther 2008 Feb 1;324(2):443-53. Epub 2007 Nov 1.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.107.13225
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February 2008

The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury.

Biochem Pharmacol 2008 Feb 18;75(4):981-95. Epub 2007 Oct 18.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323588PMC
February 2008

A haplotype analysis of CYP2E1 polymorphisms in relation to alcoholic phenotypes in Mexican Americans.

Alcohol Clin Exp Res 2007 Dec;31(12):1991-2000

Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, Kansas 66160, USA.

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http://doi.wiley.com/10.1111/j.1530-0277.2007.00533.x
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December 2007

Fenretinide-induced apoptosis of Huh-7 hepatocellular carcinoma is retinoic acid receptor beta dependent.

BMC Cancer 2007 Dec 31;7:236. Epub 2007 Dec 31.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1186/1471-2407-7-236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2249606PMC
December 2007

Genotyping and haplotyping of CYP2C19 functional alleles on thin-film biosensor chips.

Pharmacogenet Genomics 2007 Feb;17(2):103-14

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.

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February 2007

The role of retinoid X receptor alpha in regulating alcohol metabolism.

J Pharmacol Exp Ther 2006 Oct 7;319(1):360-8. Epub 2006 Jul 7.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA.

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http://dx.doi.org/10.1124/jpet.106.108175DOI Listing
October 2006

Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse.

Toxicol Sci 2006 Jul 11;92(1):33-41. Epub 2006 Apr 11.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

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July 2006

Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells.

Toxicol Sci 2006 Jul 21;92(1):51-60. Epub 2006 Apr 21.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

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http://dx.doi.org/10.1093/toxsci/kfj207DOI Listing
July 2006

Genetic polymorphism of cytochrome P450 2C19 in Mexican Americans: a cross-ethnic comparative study.

Clin Pharmacol Ther 2006 Jul 8;80(1):33-40. Epub 2006 Jun 8.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, 66160-7417, USA.

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July 2006

The effect of ethanol, ethanol metabolizing enzyme inhibitors, and Vitamin E on regulating glutathione, glutathione S-transferase, and S-adenosylmethionine in mouse primary hepatocyte.

Hepatol Res 2006 May 15;35(1):53-61. Epub 2006 Mar 15.

University of Kansas Medical Center, Department of Pharmacology, Toxicology, and Therapeutics, Kansas City, KS 66160, United States.

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http://dx.doi.org/10.1016/j.hepres.2006.02.003DOI Listing
May 2006

Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene.

BMC Genet 2006 May 18;7:29. Epub 2006 May 18.

Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA.

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http://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1488870PMC
May 2006

Identification of CYP2D6 impaired functional alleles in Mexican Americans.

Eur J Clin Pharmacol 2005 Dec 8;61(11):797-802. Epub 2005 Nov 8.

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Mail Stop 1018, Breidenthal Building, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA.

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http://link.springer.com/10.1007/s00228-005-0044-4
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December 2005

Animal models of xenobiotic receptors.

Curr Drug Metab 2005 Aug;6(4):341-55

Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.

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http://dx.doi.org/10.2174/1389200054633862DOI Listing
August 2005

Evolution of the DRD2 gene haplotype and its association with alcoholism in Mexican Americans.

Alcohol 2005 Jun;36(2):117-25

Department of Pharmacology, Toxicology & Therapeutics, Breidenthal Building, Mail Stop 1018, The University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS 66160-7417, USA.

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http://dx.doi.org/10.1016/j.alcohol.2005.09.003DOI Listing
June 2005

9-cis-retinoic acid inhibits androgen receptor activity through activation of retinoid X receptor.

Mol Endocrinol 2005 May 13;19(5):1200-12. Epub 2005 Jan 13.

George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester Medical Center, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1210/me.2004-0181DOI Listing
May 2005

Polymorphisms of CYP2C19 and CYP2D6 in Israeli ethnic groups.

Am J Pharmacogenomics 2004 ;4(6):395-401

Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, Kansas 66160-7417, USA.

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February 2005

ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles.

Alcohol Clin Exp Res 2004 Aug;28(8):1145-52

Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA, USA.

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August 2004

Induction of multidrug resistance protein 3 (mrp3) in vivo is independent of constitutive androstane receptor.

Drug Metab Dispos 2003 Nov;31(11):1315-9

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA.

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November 2003

Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment.

Biol Psychiatry 2003 Nov;54(9):879-83

Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA.

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http://dx.doi.org/10.1016/s0006-3223(03)00424-4DOI Listing
November 2003

Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice.

Endocrinology 2003 Jun;144(6):2311-8

Department of Pathology, University of Rochester, Rochester, New York 14642, USA.

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http://dx.doi.org/10.1210/en.2002-0129DOI Listing
June 2003