Yu-Hua Tseng

Yu-Hua Tseng

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Yu-Hua Tseng

Yu-Hua Tseng

Publications by authors named "Yu-Hua Tseng"

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Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes.

PLoS Biol 2020 Feb 10;18(2):e3000630. Epub 2020 Feb 10.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034924PMC
February 2020

Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer.

Methods Mol Biol 2020 ;2138:289-296

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1007/978-1-0716-0471-7_20DOI Listing
January 2020

Lipokines and Thermogenesis.

Endocrinology 2019 10;160(10):2314-2325

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1210/en.2019-00337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760332PMC
October 2019

ComBATing aging-does increased brown adipose tissue activity confer longevity?

Geroscience 2019 06 22;41(3):285-296. Epub 2019 Jun 22.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA, 02215, USA.

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http://dx.doi.org/10.1007/s11357-019-00076-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6702504PMC
June 2019

Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation.

Mol Metab 2018 12 19;18:153-163. Epub 2018 Sep 19.

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183069
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http://dx.doi.org/10.1016/j.molmet.2018.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6308035PMC
December 2018

RGB-Color Intensiometric Indicators to Visualize Spatiotemporal Dynamics of ATP in Single Cells.

Angew Chem Int Ed Engl 2018 08 18;57(34):10873-10878. Epub 2018 Jul 18.

Cell Signaling Group, Waseda Bioscience Research Institute in Singapore (WABIOS), Singapore, 138667, Republic of Singapore.

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http://dx.doi.org/10.1002/anie.201804304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456769PMC
August 2018

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism.

Cell Rep 2018 07;24(3):781-790

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117118PMC
July 2018

Protocols for Generation of Immortalized Human Brown and White Preadipocyte Cell Lines.

Methods Mol Biol 2017 ;1566:77-85

Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA.

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http://dx.doi.org/10.1007/978-1-4939-6820-6_8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870121PMC
February 2018

Deciphering adipose tissue heterogeneity.

Ann N Y Acad Sci 2018 01 1;1411(1):5-20. Epub 2017 Aug 1.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts and Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts.

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http://dx.doi.org/10.1111/nyas.13398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788721PMC
January 2018

Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes.

Cell Rep 2017 Dec;21(11):3040-3048

Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Bioinformatics Core, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247173171
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http://dx.doi.org/10.1016/j.celrep.2017.11.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5841536PMC
December 2017

Ca-associated triphasic pH changes in mitochondria during brown adipocyte activation.

Mol Metab 2017 08 31;6(8):797-808. Epub 2017 May 31.

WASEDA Bioscience Research Institute in Singapore (WABIOS), 11 Biopolis Way, #05-02 Helios, Singapore 138667, Singapore; Comprehensive Research Organization, Waseda University, Tokyo, 162-0041, Japan; PRESTO, Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518710PMC
August 2017

MicroRNA Regulation of Brown Adipogenesis and Thermogenic Energy Expenditure.

Front Endocrinol (Lausanne) 2017 23;8:205. Epub 2017 Aug 23.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.3389/fendo.2017.00205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572399PMC
August 2017

Identification and characterization of a supraclavicular brown adipose tissue in mice.

JCI Insight 2017 Jun 2;2(11). Epub 2017 Jun 2.

US Department of Agriculture/Agricultural Research Center (USDA/ARS), Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1172/jci.insight.93166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453704PMC
June 2017

Shades of brown: an introduction for the special focus issue of Adipocyte on "brown and beige/brite adipocytes".

Authors:
Yu-Hua Tseng

Adipocyte 2016 Apr;5(2):97

a Section on Integrative Physiology and Metabolism , Joslin Diabetes Center, Harvard Medical School , Boston , MA , USA.

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http://dx.doi.org/10.1080/21623945.2016.1194132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4916934PMC
April 2016

Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling.

Biochem Biophys Res Commun 2016 Feb 20;470(4):783-91. Epub 2016 Jan 20.

Division of Applied Physiology, Department of Exercise Science, University of South Carolina, Columbia, SC 29208, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.01.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768059PMC
February 2016

3D brown adipogenesis to create "Brown-Fat-in-Microstrands".

Biomaterials 2016 Jan 8;75:123-134. Epub 2015 Oct 8.

Colleges of Nanoscale Science and Engineering, SUNY Polytechnic Institute, 257 Fuller Road, Albany, NY 12203, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2015.10.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644497PMC
January 2016

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

EMBO Rep 2015 Oct 24;16(10):1378-93. Epub 2015 Aug 24.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA

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http://dx.doi.org/10.15252/embr.201540837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766451PMC
October 2015

Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning.

Sci Rep 2015 Aug 13;5:13116. Epub 2015 Aug 13.

Molecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Boston, MA.

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http://www.nature.com/articles/srep13116
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http://dx.doi.org/10.1038/srep13116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534785PMC
August 2015

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes.

Nat Med 2015 Jul 15;21(7):760-8. Epub 2015 Jun 15.

1] Section on Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA. [2] Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nm.3881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4496292PMC
July 2015

A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis.

Diabetes 2015 Jun 20;64(6):2002-14. Epub 2015 Jan 20.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db14
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http://dx.doi.org/10.2337/db14-0704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4439563PMC
June 2015

The Thermogenic Circuit: Regulators of Thermogenic Competency and Differentiation.

Genes Dis 2015 Jun 3;2(2):164-172. Epub 2015 Apr 3.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.gendis.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610149PMC
June 2015

Adipogenic fate commitment of muscle-derived progenitor cells: isolation, culture, and differentiation.

Methods Mol Biol 2014 ;1213:229-43

Research Group Adipocyte Development, German Institute of Human Nutrition, Arthur-Scheunert-Allee 114-116, Nuthetal, 14558, Germany.

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http://dx.doi.org/10.1007/978-1-4939-1453-1_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511918PMC
May 2015

Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat but normal muscle development.

Endocrinology 2015 May 27;156(5):1637-47. Epub 2015 Jan 27.

Section on Integrative Physiology and Metabolism (M.D.L., Y.-H.T.), Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215; Department of Adipocyte Development (T.J.S.), German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany 14558; Stem Cell and Regenerative Biology Department (A.J.P.), Harvard University, Cambridge, Massachusetts; and Harvard Stem Cell Institute (Y.-H.T.), Harvard University, Cambridge, Massachusetts 02138.

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http://dx.doi.org/10.1210/en.2014-1773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398768PMC
May 2015

Genetic and functional characterization of clonally derived adult human brown adipocytes.

Nat Med 2015 Apr 16;21(4):389-94. Epub 2015 Mar 16.

1] Diabetes Center, University of California, San Francisco (UCSF), San Francisco, California, USA. [2] Department of Cell and Tissue Biology, UCSF, San Francisco, California, USA. [3] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nm.3819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427356PMC
April 2015

Unwiring the transcriptional heat circuit.

Proc Natl Acad Sci U S A 2014 Oct 26;111(40):14318-9. Epub 2014 Sep 26.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215

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http://dx.doi.org/10.1073/pnas.1416145111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209983PMC
October 2014

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Cell 2014 Jul;158(1):69-83

Division of Endocrinology, Beth Israel Deaconess Medical Center and Department of Genetics, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.04.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116691PMC
July 2014

Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signalling.

Nat Commun 2014 Jun 5;5:4063. Epub 2014 Jun 5.

Division of Genetics, Boston Children's Hospital, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncomms5063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084855PMC
June 2014

Brown fat fuel utilization and thermogenesis.

Trends Endocrinol Metab 2014 Apr 2;25(4):168-77. Epub 2014 Jan 2.

Joslin Diabetes Center and Harvard Medical School, One Joslin Place, Boston, MA 02215, USA; Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2013.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972344PMC
April 2014

Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.

Cell 2014 Jan;156(3):440-55

Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674140000
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http://dx.doi.org/10.1016/j.cell.2013.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951122PMC
January 2014

Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle.

Stem Cell Reports 2014 Jan 14;2(1):92-106. Epub 2014 Jan 14.

Howard Hughes Medical Institute, Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, MA 02138, USA ; Joslin Diabetes Center and the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3966115PMC
January 2014

Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT.

J Nucl Med 2013 Nov 26;54(11):1896-901. Epub 2013 Sep 26.

Section of Integrative Physiology and Metabolism, Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.2967/jnumed.113.121012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012367PMC
November 2013

Systemic control of brown fat thermogenesis: integration of peripheral and central signals.

Ann N Y Acad Sci 2013 Oct 23;1302:35-41. Epub 2013 Sep 23.

Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.12277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805713PMC
October 2013

Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake.

Antioxid Redox Signal 2013 Jul 9;19(3):243-57. Epub 2012 Oct 9.

Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1089/ars.2012.4536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691916PMC
July 2013

Brown adipose tissue: development, metabolism and beyond.

Biochem J 2013 Jul;453(2):167-78

Research Group Adipocyte Development, German Institute of Human Nutrition, Nuthetal 14558, Germany.

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http://dx.doi.org/10.1042/BJ20130457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887508PMC
July 2013

Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.

Am J Physiol Gastrointest Liver Physiol 2013 May 28;304(10):G876-84. Epub 2013 Mar 28.

Beth Israel Deaconess Medical Center, Dana 501, 330 Brookline Ave., Boston, MA 02215, USA.

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http://dx.doi.org/10.1152/ajpgi.00305.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3652072PMC
May 2013

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

Nature 2013 Mar 13;495(7441):379-83. Epub 2013 Mar 13.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature11943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623555PMC
March 2013

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

J Clin Invest 2013 Jan 10;123(1):215-23. Epub 2012 Dec 10.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI62308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533266PMC
January 2013

Intrinsic differences in adipocyte precursor cells from different white fat depots.

Diabetes 2012 Jul 17;61(7):1691-9. Epub 2012 May 17.

Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts,USA.

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http://dx.doi.org/10.2337/db11-1753DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3379665PMC
July 2012

Brown adipose tissue: Recent insights into development, metabolic function and therapeutic potential.

Adipocyte 2012 Jan;1(1):13-24

Joslin Diabetes Center and Harvard Medical School; Boston, MA USA.

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http://dx.doi.org/10.4161/adip.18951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661118PMC
January 2012

Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways.

Endocrinology 2011 Oct 23;152(10):3680-9. Epub 2011 Aug 23.

Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-1229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176640PMC
October 2011

Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis.

Mol Cell Biol 2010 Sep 28;30(17):4224-33. Epub 2010 Jun 28.

Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1128/MCB.00363-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937545PMC
September 2010

Cellular bioenergetics as a target for obesity therapy.

Nat Rev Drug Discov 2010 Jun;9(6):465-82

Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nrd3138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880836PMC
June 2010

Insulin and insulin-like growth factor-1 receptors act as ligand-specific amplitude modulators of a common pathway regulating gene transcription.

J Biol Chem 2010 May 1;285(22):17235-45. Epub 2010 Apr 1.

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Joslin Diabetes Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M110.118620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878077PMC
May 2010

Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism.

Cytokine Growth Factor Rev 2009 Oct-Dec;20(5-6):523-31. Epub 2009 Nov 6.

Joslin Diabetes Center, One Joslin Place, and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cytogfr.2009.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2799934PMC
March 2010

Identification of somatic mutations in the von Hippel-Lindau (VHL) gene in a patient with renal cell carcinoma.

J Formos Med Assoc 2009 Nov;108(11):886-93

Department of Obstetrics and Gynecology, Jen-Ai Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1016/S0929-6646(09)60421-6DOI Listing
November 2009

Substance P as a novel anti-obesity target.

Gastroenterology 2008 Mar;134(3):747-55

Gastrointestinal Neuropeptide Center, Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1053/j.gastro.2007.12.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359157PMC
March 2008

Dissection of the insulin signaling pathway via quantitative phosphoproteomics.

Proc Natl Acad Sci U S A 2008 Feb 11;105(7):2451-6. Epub 2008 Feb 11.

Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1073/pnas.0711713105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268157PMC
February 2008

Rad GTPase deficiency leads to cardiac hypertrophy.

Circulation 2007 Dec 3;116(25):2976-2983. Epub 2007 Dec 3.

Cardiovascular Center (L.C., J.Z., C.-Q.X., T.C., S.M.D., Y.E.C.), Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich; Joslin Diabetes Center (Y.-H.T., J.I., J.C.B., C.R.K.), Harvard Medical School, Boston, Mass; Institute of Molecular Medicine (Z.S., X.Z.), Peking University, Beijing, People's Republic of China; Department of Cardiology (K.A.Y.), The Methodist Hospital Research Institute, Houston, Tex; and Cardiovascular Research Institute (Q.Y.), Morehouse School of Medicine, Atlanta, Ga.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.707257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207362PMC
December 2007

Developmental origin of fat: tracking obesity to its source.

Cell 2007 Oct;131(2):242-56

Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2007.10.004DOI Listing
October 2007

Reduced expression of the NADPH oxidase NOX4 is a hallmark of adipocyte differentiation.

Biochim Biophys Acta 2007 Jul 19;1773(7):1015-27. Epub 2007 Mar 19.

Department of Cellular Physiology and Metabolism, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1016/j.bbamcr.2007.03.003DOI Listing
July 2007

Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin.

Nat Cell Biol 2005 Jun 15;7(6):601-11. Epub 2005 May 15.

Research Division, Joslin Diabetes Center, Children's Hospital, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/ncb1259DOI Listing
June 2005

Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration.

Circulation 2005 Mar 14;111(8):1071-7. Epub 2005 Feb 14.

Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Ga 30310, USA.

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http://dx.doi.org/10.1161/01.CIR.0000156439.55349.ADDOI Listing
March 2005

Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse.

Proc Natl Acad Sci U S A 2004 Jul 6;101(28):10422-7. Epub 2004 Jul 6.

Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0402511101
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http://dx.doi.org/10.1073/pnas.0402511101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC478587PMC
July 2004

Differential roles of insulin receptor substrates in brown adipocyte differentiation.

Mol Cell Biol 2004 Mar;24(5):1918-29

Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC350563PMC
http://dx.doi.org/10.1128/mcb.24.5.1918-1929.2004DOI Listing
March 2004

Antisense thymidylate synthase electrogene transfer to increase uptake of radiolabeled iododeoxyuridine in a murine model.

J Nucl Med 2004 Mar;45(3):478-84

Cancer Center, Veterans General Hospital-Taipei, National Yang-Ming University, Taipei, Taiwan.

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March 2004

Differential roles of insulin receptor substrates in the anti-apoptotic function of insulin-like growth factor-1 and insulin.

J Biol Chem 2002 Aug 24;277(35):31601-11. Epub 2002 Jun 24.

Research Division, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M202932200DOI Listing
August 2002

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

Mol Cell Biol 2002 Feb;22(3):965-77

Research Division, Joslin Diabetes Center, Harvard Medical School. Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133541PMC
http://dx.doi.org/10.1128/mcb.22.3.965-977.2002DOI Listing
February 2002