Publications by authors named "Yu Xie"

419 Publications

The prognostic value of serum albumin levels and respiratory rate for community-acquired pneumonia: A prospective, multi-center study.

PLoS One 2021 4;16(3):e0248002. Epub 2021 Mar 4.

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, People's Republic of China.

Community-acquired pneumonia (CAP) is a respiratory disease frequently requiring hospital admission, and a significant cause of death worldwide. This study aimed to investigate the prognostic value of clinical indicators. A prospective, multi-center study was conducted (January 2017-December 2018) where patient demographic and clinical data were recorded (N = 366). The 30-day mortality rate was 5.46%. Cox Regression analyses showed that serum albumin (ALB) and respiratory rate (RR) were independent prognostic variables for 30-day survival in patients with CAP. Albumin negatively correlated with the Pneumonia Severity Index (PSI) and CURB-65 scores using Pearson and Spearman tests. Survival curves showed that a RR >24 breaths/min or ALB ≤30 g/L were associated with a significantly higher risk of mortality. The area-under-the-curve (AUC) for predicting 30-day mortality in patients with CAP was 0.762, 0.763, 0.790, and 0.784 for ALB, RR, PSI, and CURB-65, respectively. The AUC for the prediction of 30-day mortality using ALB combined with PSI, CURB-65 scores, and RR was 0.822 (95% CI 0.731-0.912), 0.847 (95% CI 0.755-0.938), and 0.847 (95% CI 0.738-0.955), respectively. Albumin and RR were found to be reliable prognostic factors for CAP. This combination showed equal predictive value when compared to adding ALB assessment to PSI and CURB-65 scores, which could improve their prognostic accuracy.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0248002PLOS
March 2021

Transcription factor WRKY22 regulates canker susceptibility in sweet orange (Citrus sinensis Osbeck) by enhancing cell enlargement and CsLOB1 expression.

Hortic Res 2021 Mar 1;8(1):50. Epub 2021 Mar 1.

Citrus Research Institute, Southwest University/Chinese Academy of Agricultural Sciences, Chongqing, People's Republic of China.

Pathological hypertrophy (cell enlargement) plays an important role in the development of citrus canker, but its regulators are largely unknown. Although WRKY22 is known to be involved in pathogen-triggered immunity and positively regulates resistance to bacterial pathogens in Arabidopsis, rice and pepper, the CRISPR/Cas9-mediated partial knockout of CsWRKY22 improves resistance to Xanthomonas citri subsp. citri (Xcc) in Wanjincheng orange (Citrus sinensis Osbeck). Here, we demonstrate that CsWRKY22 is a nucleus-localized transcriptional activator. CsWRKY22-overexpressing plants exhibited dwarf phenotypes that had wrinkled and thickened leaves and were more sensitive to Xcc, whereas CsWRKY22-silenced plants showed no visible phenotype changes and were more resistant to Xcc. Microscopic observations revealed that the overexpression of CsWRKY22 increased cell size in the spongy mesophyll. Transcriptome analysis showed that cell growth-related pathways, such as the auxin and brassinosteroid hormonal signaling and cell wall organization and biogenesis pathways, were significantly upregulated upon CsWRKY22 overexpression. Interestingly, CsWRKY22 activated the expression of CsLOB1, which is a key gene regulating susceptibility to citrus canker. We further confirmed that CsWRKY22 bound directly to the W-boxes just upstream of the transcription start site of CsLOB1 in vivo and in vitro. We conclude that CsWRKY22 enhances susceptibility to citrus canker by promoting host hypertrophy and CsLOB1 expression. Thus, our study provides new insights into the mechanism regulating pathological hypertrophy and the function of WRKY22 in citrus.
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http://dx.doi.org/10.1038/s41438-021-00486-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917094PMC
March 2021

New bitongling (NBTL) ameliorates rheumatoid arthritis in rats through inhibiting JAK2/STAT3 signaling pathway.

Eur J Histochem 2021 Feb 17;65(1). Epub 2021 Feb 17.

Affiliated Hospital of Nanjing University of Chinese Medicine; Jiangsu Province Hospital of Chinese Medicine, Nanjing.

Rheumatoid arthritis (RA) is featured by a variety of physical symptoms and fibroblast-like synoviocytes (FLSs) abnormal proliferation. Increasing evidence has demonstrated that traditional Chinese medicine exerts an important role in RA treatment. New bitongling (NBTL) as one of the traditional Chinese medicine has been reported to be involved in the progression of RA, but the exact mechanism is unclear. In our study, we intended to investigate the effect of NBTL on RA to identify the mechanisms related to JAK2/STAT3 signaling pathway. Extracts of Tripterygium wilfordii (TW), a traditional Chinese herbal medicine, have been widely used for treating RA in China for several decades, so, TW was used as a positive control drug for TBNL. RA rats were constructed by immunization with collagen type II to evaluate the action of NBTL in vivo. Body weight and arthritic index were evaluated. Hematoxylin and Eosin staining was performed to analysis the morphological changes of ankle joints tissue. TUNEL and flow cytometry were performed to examine cell apoptosis, while CCK8 and Ethynyl-2'-deoxyuridine (EdU) were performed to examine cell proliferation. In addition, the markers of inflammation were detected by Western blot, ELISA, and RT-qPCR. Firstly, we find that rats treated with NBTL or TW not only reduced swelling degree and bone destruction, but also repressed IL-1 β and IL-6 levels. In addition, NBTL and TW could increase the weight of rats, and promote the level of IL-10 and IL-4 in vivo. Furthermore, NBTL inhibited inflammation of FLS, induced cell apoptosis and hindered cell proliferation, which was reversed by dipeptidyl peptidase (DPP), a JAK2/STAT3 pathway activator. Taken together, NBTL potentially retarded RA via JAK2/STAT3 pathway, highlighting novel mechanisms associated with RA.
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http://dx.doi.org/10.4081/ejh.2021.3202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7907992PMC
February 2021

Corrigendum: Polyphenols Attenuate Inflammatory Response Modulating the Crosstalk Between Macrophages and Adipocytes.

Front Immunol 2021 28;12:633354. Epub 2021 Jan 28.

Institute of Infection and Immunity of Huaihe Hospital, Henan University, Kaifeng, China.

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http://dx.doi.org/10.3389/fimmu.2021.633354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877251PMC
January 2021

Phyllanthin prevents diethylnitrosamine (DEN) induced liver carcinogenesis in rats and induces apoptotic cell death in HepG2 cells.

Biomed Pharmacother 2021 Feb 12;137:111335. Epub 2021 Feb 12.

Department of Hepato-pancreato-biliary Surgery, Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China. Electronic address:

Liver cancer is a critical clinical condition with augmented malignancy, rapid progression, and poor prognosis. Liver cancer often initiates as fibrosis, develops as cirrhosis, and results in cancer. For centuries, medicinal plants have been incorporated in various liver-associated complications, and recently, research has recognized that many bioactive compounds from medicinal plants may interact with targets related to liver disorders. Phyllanthin from the Phyllanthus species is one such compound extensively used by folklore practitioners for various health benefits. However, most practices continue to be unrecognized scientifically. Hence, in this work, we investigated the protective role of phyllanthin on diethylnitrosamine (DEN) induced liver carcinoma in Wistar Albino rats and the anti-tumor potential on human hepatocellular carcinoma (HCC) HepG2 cells. The DEN-challenged liver cancer in experimental rats caused increased liver weight, 8-OHD, hepatic tissue injury marker, lipid peroxidation, and tumor markers levels. Remarkably, phyllanthin counteracted the DEN effect by ameliorating all the liver function enzymes, oxidative DNA damage, and tumor-specific markers by enhanced anti-oxidant capacity and induced caspase-dependent apoptosis through the mTOR/ PI3K signaling pathway. MTT assay demonstrated that phyllanthin inhibited the HepG2 cell growth in a dose-dependent manner. Fascinatingly, phyllanthin did not demonstrate any substantial effect on the normal cell line, HL7702. In addition, HepG2 cells were found in the late apoptotic stage upon treatment with phyllanthin as depicted by acridine orange/ethidium bromide staining. Overall, this work offers scientific justification that phyllanthin can be claimed to be a safe candidate with potential chemotherapeutic activity against HCC.
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http://dx.doi.org/10.1016/j.biopha.2021.111335DOI Listing
February 2021

Positive Inotropic Effects of ATP Released the Maxi-Anion Channel in Langendorff-Perfused Mouse Hearts Subjected to Ischemia-Reperfusion.

Front Cell Dev Biol 2021 21;9:597997. Epub 2021 Jan 21.

National Institute for Physiological Sciences (NIPS), Okazaki, Japan.

The organic anion transporter SLCO2A1 constitutes an essential core component of the ATP-conductive large-conductance anion (Maxi-Cl) channel. Our previous experiments using Langendorff-perfused mouse hearts showed that the Maxi-Cl channel contributes largely to the release of ATP into the coronary effluent observed during 10-min reperfusion following a short period (6 min) of oxygen-glucose deprivation. The present study examined the effect of endogenous ATP released Maxi-Cl channels on the left ventricular contractile function of Langendorff-perfused mouse hearts, using a fluid-filled balloon connected to a pressure transducer. After the initial 30-min stabilization period, the heart was then perfused with oxygen-glucose-deprived Tyrode solution for 6 min, which was followed by a 10-min perfusion with oxygenated normal Tyrode solution in the absence and presence of an ATP-hydrolyzing enzyme, apyrase, and/or an adenosine A1 receptor antagonist, 8-cyclopentyl-1,3-dipropylxanthine (DPCPX). In the absence of apyrase and DPCPX, the left ventricular developed pressure (LVDP) decreased from a baseline value of 72.3 ± 7.1 to 57.5 ± 5.5 mmHg ( = 4) at the end of 6-min perfusion with oxygen-glucose-deprived Tyrode solution, which was followed by a transient increase to 108.5 ± 16.5 mmHg during subsequent perfusion with oxygenated normal Tyrode solution. However, in the presence of apyrase and DPCPX, the LVDP decreased to the same degree during 6-min perfusion with oxygen-glucose-deprived Tyrode solution, but failed to exhibit a transient increase during a subsequent perfusion with oxygenated normal Tyrode solution. These results strongly suggest that endogenous ATP released through Maxi-Cl channels contributes to the development of transient positive inotropy observed during reperfusion after short-period hypoxia/ischemia in the heart.
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http://dx.doi.org/10.3389/fcell.2021.597997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859278PMC
January 2021

Effects and potential mechanisms of rapamycin on MPTP-induced acute Parkinson's disease in mice.

Ann Palliat Med 2021 Feb 7. Epub 2021 Feb 7.

Department of Neurology Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Parkinson's disease is the second major neurodegenerative diseases secondarily to Alzheimer's disease. Rapamycin is a fermentation product, which derived from Streptomyces hygroscopius. The aim of this study is to investigate the effect of rapamycin and its potential mechanisms on the acute attack of 1-methyl-4-phenyl-1,2,3,6-four hydrogen pyridine (MPTP) induced Parkinson's disease (PD) in mice.

Methods: PD model was established by intraperitoneal injection of MPTP for 5 days. The effect of intraperitoneal injection of rapamycin for treating the symptoms caused by PD was evaluated by behavior observation and HE pathological section. In order to understand the possible mechanism, immunofluorescence and immune precipitation mainly analyzes were used to measure the expression of critical protein p-4ebp1 in mammalian target of rapamycin (mTOR) signaling pathways in the striatum and substantia nigra.

Results: Rapamycin can effectively alleviate symptoms of PD. The levels of key protein p-4EBP1 in the striatum and substantia nigra were both significantly higher in PD group compared with control group (P<0.01), while being pretreated with rapamycin, the expression of p-4EBP1 in the striatum and substantia nigra were both decreased obviously (P<0.01).

Conclusions: p-4EBP1 protein may be involved in the pathogenesis of PD via mTOR signaling pathway. Inhibited mTOR-4EBP1 pathways could make a certain protective effect for the acute attack of PD induced by MPTP.
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http://dx.doi.org/10.21037/apm-20-1096DOI Listing
February 2021

Human Serum-derived Extracellular Vesicles Protect A549 from PM -induced Cell Apoptosis.

Biomed Environ Sci 2021 Jan;34(1):40-49

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.

Objective: Epidemiological studies reveal that exposure to fine particulate matter (aerodynamic diameter ≤ 2.5 μm, PM ) increases the morbidity and mortality of respiratory diseases. Emerging evidence suggests that human circulating extracellular vesicles (EVs) may offer protective effects against injury caused by particulate matter. Currently, however, whether EVs attenuate PM -induced A549 cell apoptosis is unknown.

Methods: EVs were isolated from the serum of healthy subjects, quantified nanoparticle tracking analysis, and qualified by the marker protein CD63. PM -exposed (50 μg/mL) A549 cells were pre-treated with 10 μg/mL EVs for 24 h. Cell viability, cell apoptosis, and AKT activation were assessed via Cell Counting Kit-8, flow cytometry, and Western blot, respectively. A rescue experiment was also performed using MK2206, an AKT inhibitor.

Results: PM exposure caused a 100% increase in cell apoptosis. EVs treatment reduced cell apoptosis by 10%, promoted cell survival, and inhibited the PM -induced upregulation of Bax/Bcl2 and cleaved caspase 3/caspase 3 in PM -exposed A549 cells. Moreover, EVs treatment reversed PM -induced reductions in p-AKT and p-AKT . AKT inhibition attenuated the anti-apoptotic effect of EVs treatment on PM -exposed A549 cells.

Conclusions: EVs treatment promotes cell survival and attenuates PM -induced cell apoptosis AKT phosphorylation. Human serum-derived EVs may be an efficacious novel therapeutic strategy in PM -induced lung injury.
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http://dx.doi.org/10.3967/bes2021.006DOI Listing
January 2021

[Pregnancy-preserving and maternal-fetal management in a patient with rare large cell neuroendocrine carcinoma of the uterine cervix].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Jan;41(1):1-9

Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.

Objective: To explore the strategy of pregnancy-preserving and maternal- fetal management in patients with primary gynecologic neuroendocrine tumors (gNETs) during pregnancy.

Methods: We performed whole genome sequencing (WGS) for analyzing maternal and fetal somatic and germline single nucleotide variations (SNVs) and small insertions and deletions (InDels) for a 29-year-old pregnant woman diagnosed with stage IB2 large cell neuroendocrine carcinoma (LCNEC) and adenocarcinoma in the cervix. A systematic literature review was performed to explore the strategies for treatment of such rare histological type while maintaining pregnancy.

Results: Global case analysis of cervical NETs during pregnancy suggested that negative lymph node metastasis and an early FIGO stage were potentially associated with a good prognosis of the patients. In the case presented herein, a pregnancy-preserving strategy was adopted and favorable maternal-fetal outcomes were achieved after neoadjuvant chemotherapy, radical surgery and postoperative systemic chemotherapy. At 35 weeks, the fetus was delivered by caesarian section, and the patient has by now had a disease-free survival of 19 months postoperatively. WGS analysis revealed 6 missense somatic pathogenic mutations in two cancer tissues of the patient, and among them KARS and VEGFA were related with targeted therapy. Five pathogenic germline variants were detected in the patient and her son, suggesting the necessity of a long-term follow-up schedule including precise genetic counselling for both the mother and the child.

Conclusions: Although gNETs in pregnancy are rare and highly risky, pregnancy-preserving managements of gNETs can still be considered and favorable maternalfetal outcomes are possible with proper assessment of the clinical indications and implementation of multimodal treatments. Precise treatment and follow-up strategies based on the results of WGS for risk-reducing intervention of cancer recurrence or occurrence can potentially benefit the patient and the neonate.
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http://dx.doi.org/10.12122/j.issn.1673-4254.2021.01.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867493PMC
January 2021

Evaluation of an electrochemically aligned collagen yarn for textile scaffold fabrication.

Biomed Mater 2021 Jan 25. Epub 2021 Jan 25.

Wilson College of Textiles, North Carolina State University, 1000 Main Campus Dr, Raleigh, North Carolina, 27606, UNITED STATES.

Collagen is the major component of the extracellular matrix (ECM) in human tissues and widely used in the fabrication of tissue engineered scaffolds for medical applications. However, these forms of collagen gels and films have limitations due to their inferior strength and mechanical performance and their relatively fast rate of degradation. A new form of continuous collagen yarn has recently been developed for potential usage in fabricating textile tissue engineering scaffolds. In this study, we prepared the continuous electrochemical aligned collagen yarns from acid-soluble collagen that was extracted from rat tail tendons using 0.25 M acetic acid. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Fourier transform infrared spectroscopy (FTIR) confirmed that the major component of the extracted collagen contained alpha 1 and alpha 2 chains and the triple helix structure of Type 1 collagen. The collagen solution was processed to monofilament yarns in continuous lengths by using a rotating electrode electrochemical compaction device. Exposing the non-crosslinked collagen yarns and the collagen yarns crosslinked with 1-ethyl-3-(-3-dimethyl-aminopropyl) carbodiimide hydrochloride (EDC) to normal physiological hydrolytic degradation conditions showed that both yarns were able to maintain their tensile strength during the first six weeks of the study. Cardiosphere-derived cells (CDCs) showed significantly enhanced attachment and proliferation on the collagen yarns compared to synthetic polylactic acid (PLA) filaments. Moreover, the cells were fully spread and covered the surface of the collagen yarns, which confirmed the superiority of collagen in terms of promoting cellular adhesion. The results of this work indicated that the aligned rat-tail tendon collagen yarns are favorable for fabricating biotextile scaffolds and are encouraging for further studies of various textile structure for different tissue engineering applications.
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http://dx.doi.org/10.1088/1748-605X/abdf9eDOI Listing
January 2021

Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke.

Aging (Albany NY) 2021 01 21;13(2):3060-3079. Epub 2021 Jan 21.

Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Guangzhou, China.

To investigate the therapeutic mechanism of action of transplanted stem cells and develop exosome-based nanotherapeutics for ischemic stroke, we assessed the effect of exosomes (Exos) produced by human umbilical cord mesenchymal stem cells (hUMSCs) on microglia-mediated neuroinflammation after ischemic stroke. Our results found that injected hUMSC-Exos were able to access the site of ischemic damage and could be internalized by cells both and . , treatment with hUMSC-Exos attenuated microglia-mediated inflammation after oxygen-glucose deprivation (OGD). results demonstrated that treatment with hUMSC-Exos significantly reduced infarct volume, attenuated behavioral deficits, and ameliorated microglia activation, as measured three days post-transient brain ischemia. Furthermore, miR-146a-5p knockdown (miR-146a-5p k/d Exos) partially reversed the neuroprotective effect of hUMSC-Exos. Our mechanistic study demonstrated that miR-146a-5p in hUMSC-Exos reduces microglial-mediated neuroinflammatory response through IRAK1/TRAF6 pathway. We conclude that miR-146a-5p derived from hUMSC-Exos can attenuate microglia-mediated neuroinflammation and consequent neural deficits following ischemic stroke. These results elucidate a potential therapeutic mechanism of action of mesenchymal stem cells and provide evidence that hUMSC-Exos represent a potential cell-free therapeutic option for ischemic stroke.
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http://dx.doi.org/10.18632/aging.202466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880318PMC
January 2021

TiO Nanowires with Doped g-CN Nanoparticles for Enhanced H Production and Photodegradation of Pollutants.

Nanomaterials (Basel) 2021 Jan 19;11(1). Epub 2021 Jan 19.

School of Civil Engineering and Architecture, East China Jiaotong University, Nanchang 330013, China.

With the rapid consumption of fossil fuels, along with the ever-increasing environmental pollution, it is becoming a top priority to explore efficient photocatalysts for the production of renewable hydrogen and degradation of pollutants. Here, we fabricated a composite of g-CN/TiO via an in situ growth method under the conditions of high-temperature calcination. In this method, TiO nanowires with a large specific surface area could provide enough space for loading more g-CN nanoparticles to obtain CN/TiO composites. Of note, the g-CN/TiO composite could effectively photocatalyze both the degradation of several pollutants and production of hydrogen, both of which are essential for environmental governance. Combining multiple characterizations and experiments, we found that the heterojunction constructed by the TiO and g-CN could increase the photocatalytic ability of materials by prompting the separation of photogenerated carriers. Furthermore, the photocatalytic mechanism of the g-CN/TiO composite was also clarified in detail.
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http://dx.doi.org/10.3390/nano11010254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835803PMC
January 2021

Prevalence and dynamic characteristics of generalized joint hypermobility in college students.

Gait Posture 2021 Feb 14;84:254-259. Epub 2020 Dec 14.

Department of Orthopaedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510000, Guangdong, China. Electronic address:

Background: Generalized joint hypermobility (GJH) is a common, but often ignored, condition characterized by general joint laxity, which is reported to increase one's risk of anterior cruciate ligament (ACL) injury and osteoarthritis. Nevertheless, it is not clearly learned in the prevalence and dynamic characteristics in college students.

Research Question: Is the active motion stability in the six-degree-of-freedom (6DOF) kinematics of the knee joint of people with GJH poorer than that of others?

Methods: This is a cross-sectional study. A population of 489 college students was recruited who was divided into two groups: a GJH group (Beighton score ≥ 4, n = 54) and a normal group (Beighton score < 4, n = 435). A paper questionnaire with questions about the participants' demographic characteristics and musculoskeletal disorder symptoms was collected. A three-dimensional gait analysis system was used to collect the participants' knee joint kinematic parameters during treadmill walking. Variables were evaluated using independent t-tests and Wilcoxon signed-rank tests.

Results: The prevalence of GJH was found to be 11.0 % among college students. Participants with GJH exhibited a greater active range of motions in the anterior/posterior translation than the normal (P =  0.026). Participants with GJH exhibited greater flexion at the end of the terminal stance (P = 0.039) and greater anterior translation of the tibia during almost the whole gait period than the normal group (P<0.05) during the treadmill gait. A greater external angle was found in GJH group during the periods of middle stance (P = 0.008).

Significance: GJH with a prevalence of 11.0 % among college students should be paid attention. Poor active motion stability in anterior/posterior translation may play an important role in the development of knee joint instability, potentially resulting in subsequent ACL deficiency and the development of knee osteoarthritis among people with GJH.
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http://dx.doi.org/10.1016/j.gaitpost.2020.12.002DOI Listing
February 2021

Titanium mesh for bone augmentation in oral implantology: current application and progress.

Int J Oral Sci 2020 12 30;12(1):37. Epub 2020 Dec 30.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Department of Implant Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Guided bone regeneration (GBR) is an effective and simple method for bone augmentation, which is often used to reconstruct the alveolar ridge when the bone defect occurs in the implant area. Titanium mesh has expanded the indications of GBR technology due to its excellent mechanical properties and biocompatibility, so that the GBR technology can be used to repair alveolar ridges with larger bone defects, and can obtain excellent and stable bone augmentation results. Currently, GBR with titanium mesh has various clinical applications, including different clinical procedures. Bone graft materials, titanium mesh covering methods, and titanium mesh fixing methods are also optional. Moreover, the research of GBR with titanium mesh has led to multifarious progresses in digitalization and material modification. This article reviews the properties of titanium mesh and the difference of titanium mesh with other barrier membranes; the current clinical application of titanium mesh in bone augmentation; common complications and management and prevention methods in the application of titanium mesh; and research progress of titanium mesh in digitization and material modification. Hoping to provide a reference for further improvement of titanium mesh in clinical application and related research of titanium mesh.
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http://dx.doi.org/10.1038/s41368-020-00107-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773733PMC
December 2020

Synthesis of mitochondria-targeted coumarin-3-carboxamide fluorescent derivatives: Inhibiting mitochondrial TrxR2 and cell proliferation on breast cancer cells.

Bioorg Med Chem Lett 2021 Feb 21;33:127750. Epub 2020 Dec 21.

School of Pharmacy, Lanzhou University, Lanzhou 730000, China. Electronic address:

Targeting specific mitochondrial alterations to kill cancer cells without affecting their normal counterparts emerges as a feasible strategy. Coumarin derivatives have demonstrated the potential anti-breast cancer activities. By coupling coumarin-3-carboxamide derivatives with mitochondria carrier triphenylphosphonium, mitocoumarins 15a-c were produced and tested as the anti-breast cancer fluorescence agents. Among them, 15b as the amide-based drug potently suppressed the cell growth in MCF-7, MDA-231, SK-BR-3 breast cancer cells with the IC values from 3.0 to 4.1 μM, including the lower cytotoxicity to normal MCF-10A cells with the IC value around 45.30 ± 2.45 μM. In mechanistic study for 15b in MDA-MB-231 cells, it could localize in mitochondria to elicit ROS burst and collapse Δψ. Besides, it could deplete GSH by an irreversible alkylation process and moderately inhibit mitochondrial thioredoxin reductase TrxR2, thus leading to aggravate cellular oxidative stress. This study reported 15b might be useful for the further development into a mitochondria-targeted anti-triple negative breast cancer drug.
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http://dx.doi.org/10.1016/j.bmcl.2020.127750DOI Listing
February 2021

Wnt signalling pathway in bladder cancer.

Cell Signal 2021 Mar 17;79:109886. Epub 2020 Dec 17.

Department of Urology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518052, China; Department of Urology, the Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University, Hunan Cancer Hospital, Changsha, Hunan 410013, China; The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen 518060, China. Electronic address:

Bladder cancer (BC) is one of the most common tumours of the urinary system and is also known as a highly malignant tumour. In addition to conventional diagnosis and treatment methods, recent research has focused on studying the molecular mechanisms related to BC, in the hope that new, less toxic and effective targeted anticancer drugs and new diagnostic markers can be discovered. It is known that the Wingless (Wnt) signalling pathway and its related genes, proteins and other substances are involved in multiple biological processes of various tumours. Clarifying the contribution of the Wnt signalling pathway in bladder tumours will help establish early diagnosis indicators, develop new therapeutic drugs and evaluate the prognosis for BC. This review aims to summarise previous studies related to BC and the Wnt signalling pathway, with a focus on exploring the participating substances and their mechanisms in the regulation of the Wnt signalling pathway to better determine how to promote new chemotherapeutic drugs, potential therapeutic targets and diagnostic biomarkers.
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http://dx.doi.org/10.1016/j.cellsig.2020.109886DOI Listing
March 2021

Tumor-associated macrophage polarization promotes the progression of esophageal carcinoma.

Aging (Albany NY) 2020 12 15;13(2):2049-2072. Epub 2020 Dec 15.

Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases (Ministry of Education), Department of Pathology, The First Affiliated Hospital, Shihezi University School of Medicine, Xinjiang 832000, China.

The immune response facilitated by tumor-associated macrophages is a vital determinant of tumor progression. We identified differentially expressed genes between various macrophage phenotypes in the Gene Expression Omnibus, and used Kaplan-Meier Plotter to determine which of them altered the prognosis of esophageal carcinoma patients. Fibrinogen-like protein 2 (), an immunosuppressive factor in the tumor microenvironment of various cancers, was upregulated in M2 macrophages, and higher expression was associated with poorer survival in esophageal carcinoma patients. Using the TIMER database, we found that expression correlated positively with the levels of immune markers of infiltrating B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells in esophageal carcinoma samples. Correlation analyses in cBioPortal revealed that the mRNA levels of correlated strongly with those of interleukin 10, matrix metalloproteinase 9, C-C motif chemokine ligand 5, T-cell immunoglobulin mucin 3, interleukin 13, vascular cell adhesion molecule 1, macrophage colony-stimulating factor and fibroblast growth factor 7 in esophageal carcinoma tissues. The same cytokines were upregulated when esophageal squamous cell carcinoma cells were co-cultured with M2-like tumor-associated macrophages. Thus, by secreting FGL2, M2-like tumor-associated macrophages may create an immunosuppressive tumor microenvironment that induces the occurrence and progression of esophageal carcinoma.
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http://dx.doi.org/10.18632/aging.202201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7880404PMC
December 2020

The optimization conditions of establishing H9c2 cardiomyocyte hypoxia/reoxygenation injury model based on AnaeroPack System.

Cell Biol Int 2020 Dec 2. Epub 2020 Dec 2.

Department of Pharmacy, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116023, P.R. China.

Ischemia-reperfusion (I/R) injury is a major cause of cardiomyocyte apoptosis after vascular recanalization, which was mimicked by a hypoxia/reoxygenation (H/R) injury model of cardiomyocytes in vitro. In this study, we explored an optimal H/R duration procedure using the AnaeroPack System. To study H/R procedure, cardiomyocytes were exposed to AnaeroPack System with sugar and serum-free medium, followed by reoxygenation under normal condition. Cell injury was detected through lactate dehydrogenase (LDH) and cardiac troponin (c-Tn) release, morphological changes, cell apoptosis and expression of apoptosis-related proteins. The results showed that the damage to H9c2 cells increased with prolonged hypoxia time, as demonstrated by increased apoptosis rate, LDH and c-Tn release, HIF-1α expression, as well as decreased expression of Bcl-2. Furthermore, hypoxia for 10 h and reoxygenation for 6 h exhibited the highest apoptosis rate and damage cytokine release; in addition, cells were deformed, small and visibly round. After 12 h of hypoxia, majority of the cells were dead. Taken together, this study showed that subjecting H9c2 cells to the AnaeroPack System for 10 h and reoxygenation for 6 h can achieve a practicable and repeatable H/R injury model. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/cbin.11513DOI Listing
December 2020

Mental health and psychological responses during the coronavirus disease 2019 (COVID-19) epidemic: A comparison between Wuhan and other areas in China.

Psychosom Med 2020 Dec 4. Epub 2020 Dec 4.

Department of Neurology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P.R. China.

Objective: To compare the mental health and psychological responses in Wuhan, a severely affected area, and other areas of China, during the coronavirus disease 2019 (COVID-19) epidemic.

Methods: This cross-sectional study was conducted during February 10-20, 2020. A set of online questionnaires was employed to measure mental health and responses. 1,397 participants from Wuhan (age: 36.4 ± 10.7; male: 36.1%) and 2,794 age- and sex-matched participants from other areas of China (age: 35.9 ± 9.9; male: 39.0%) were recruited.

Results: Compared with their counterparts, participants from Wuhan had significantly higher prevalence of any mental health problems (46.6% vs. 32.2%; adjusted OR=1.89, 95%CI=1.65-2.17), anxiety (15.2% vs. 6.2%; adjusted OR=2.65, 95%CI=2.14-3.29), depression (18.3% vs. 9.7%; adjusted OR = 2.11, 95%CI=1.74-2.54), suicidal ideation (10.5% vs. 7.1%; adjusted OR=1.60, 95%CI=1.28-2.02), and insomnia (38.6% vs. 27.6%; adjusted OR=1.70, 95%CI=1.48-1.96). Participants from Wuhan had a slightly higher rate of help-seeking behavior (7.1% vs. 4.2%, adjusted OR=1.76, 95% CI=1.12-2.77) but similar rate of treatment (3.5% vs. 2.7%, adjusted OR = 1.23, 95% CI=0.68-2.24) for mental problems than their counterparts. In addition, compared with their counterparts, participants from Wuhan gave higher proportions of responses regarding "fearful" (52% vs. 36%, P < .001), "discrimination against COVID-19 cases" (64% vs. 58%, P = .006), "strictly comply with preventive behaviors" (98.7% vs. 96%, P =.003), and "fewer living and medical supplies" (<2 weeks: 62% vs. 57%, P = .015).

Conclusions: The COVID-19 epidemic has raised enormous challenges regarding public mental health and psychological responses, especially in the highly affected Wuhan area. The present findings provide important information for developing appropriate strategies for the prevention and management of mental health problems during COVID-19 and other epidemics.
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http://dx.doi.org/10.1097/PSY.0000000000000892DOI Listing
December 2020

Distribution and prognostic impact of M1 macrophage on esophageal squamous cell carcinoma.

Carcinogenesis 2020 Dec 3. Epub 2020 Dec 3.

Department of Pathology and Key Laboratory of Xinjiang Endemic and Ethnic Diseases (Ministry of Education) / Department of Pathology, the First Affiliated Hospital, Shihezi University School of Medicine, Shihezi, China.

Macrophages are a double-edged sword with potential cancer-promoting and anti-cancer effects. Controversy remains regarding the effect of macrophages, especially M1 macrophages, on tumor promotion and suppression. We aimed to investigate the role of M1 macrophages in the occurrence and progression of esophageal squamous cell carcinoma (ESCC). Analyzing the data in Gene Expression Omnibus (GEO) database by The CIBERSORT algorithm found that M1 macrophages were one of the important components of many immune cells in ESCCs, and the increased in their number was obviously negatively correlated with tumor T staging. This result was verified by our experimental data: the density of CD68/HLA-DR double-stained M1 macrophages in ESCC tumor nest and tumor stroma were significantly higher than that in cancer-adjacent normal (CAN) tissues. The density of M1 macrophages in ESCC tumor nest was negatively correlated with the patient's lymph node metastasis and clinical stage (P < 0.05), and the negative tendency was more obvious for M1 macrophages in ESCC tumor stroma (P < 0.001). Exposure to M1 macrophage CM inhibited ESCC cell migration and invasion ability significantly (P < 0.05). Moreover, the increased M1 macrophage density in ESCC tumor stroma correlated positively with good prognosis of ESCC. M1 macrophages were involved in inhibiting ESCC cell migration and invasion, which could serve as a good prognostic factor in patients with ESCC.
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http://dx.doi.org/10.1093/carcin/bgaa128DOI Listing
December 2020

Candidal periprosthetic joint infection after primary total knee arthroplasty combined with ipsilateral intertrochanteric fracture: A case report.

World J Clin Cases 2020 Nov;8(21):5401-5408

Department of Trauma Surgery, State Key Laboratory of Trauma, Burns and Combined Injuries, Medical Center of Trauma and War Injury, Daping Hospital, Army Medical University of PLA, Chongqing 400042, China.

Background: Candidal periprosthetic joint infection is a rare and difficult to diagnose complication of total knee arthroplasty. The treatment of such complications is inconclusive and may include prosthesis removal, debridement, arthrodesis, and extensive antifungal therapy to control the infection.

Case Summary: A 62-year-old male with a history of total knee arthroplasty (TKA) in his left knee presented with ipsilateral knee pain and a sinus discharge 20 mo after TKA. The patient was previously evaluated for left knee pain, swelling, and a transient fever one month postoperatively. Prothesis removal and insertion of a cement spacer were performed in a local hospital six months prior to the current presentation. Medical therapy included rifampicin and amphotericin which were administered for 4 wk following prosthesis removal. A second debridement was performed in our hospital and was detected in the knee joint. Fourteen weeks following the latter debridement, the patient suffered a left intertrochanteric fracture and received closed reduction and internal fixation with proximal femoral nail anterotation. Two weeks after fracture surgery, a knee arthrodesis with autograft was performed using a double-plate fixation. The patient recovered adequately and was subsequently discharged. At the two-year follow-up, the patient has a stable gait with a pain-free, fused knee.

Conclusion: Fungal periprosthetic joint infection following TKA may be successfully and safely treated with prosthesis removal, exhaustive debridement, and arthrodesis after effective antifungal therapy. Ipsilateral intertrochanteric fractures of the affected knee can be safely fixated with internal fixation if the existing infection is clinically excluded and aided by the investigation of serum inflammatory markers.
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http://dx.doi.org/10.12998/wjcc.v8.i21.5401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7674749PMC
November 2020

A hybrid vascular graft harnessing the superior mechanical properties of synthetic fibers and the biological performance of collagen filaments.

Mater Sci Eng C Mater Biol Appl 2021 Jan 22;118:111418. Epub 2020 Aug 22.

Wilson College of Textiles, North Carolina State University, Raleigh, NC, USA; College of Textiles, Donghua University, Songjiang District, Shanghai, China. Electronic address:

Tissue-engineered small caliber vascular grafts have attracted much research attention as a viable alternative to traditional vascular grafts with their biocompatibility and potential to achieve complete healing. However, the major challenge is to fabricate a scaffold with both satisfactory mechanical properties and fast endothelialization. In this study, a hybrid tubular vascular tissue engineered scaffold has been circular-knitted using novel electrochemically aligned collagen (ELAC) filaments plied together with traditional poly(lactic acid) (PLA) yarn. The collagen component was able to promote the recruitment and proliferation of endothelial cells by increasing the initial cell adhesion 10-fold and the eventual cell population 3.2 times higher than the PLA scaffold alone. At the same time, the PLA yarn was able to provide sufficient mechanical strength and structural stability, as well as facilitate scaffold fabrication on high speed textile production equipment. The tubular hybrid scaffold exhibited excellent bursting strength (1.89 ± 0.43 MPa) and suture retention strength (10.86 ± 0.49 N), and had comparable compliance (3.98 ± 1.94%/100 mmHg) to that of the coronary artery (3.8 ± 0.3%/100 mmHg) under normotensive pressure. With its excellent mechanical and biological performance, this prototype hybrid scaffold is a promising candidate for the construction of a clinically successful and easily translatable tissue-engineered small caliber vascular graft.
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http://dx.doi.org/10.1016/j.msec.2020.111418DOI Listing
January 2021

Can new energy vehicles subsidy curb the urban air pollution? Empirical evidence from pilot cities in China.

Sci Total Environ 2021 Feb 5;754:142232. Epub 2020 Sep 5.

School of Economics and Trade, Hunan University, Changsha 410079, China.

New energy vehicles (NEVs) are considered as the potential measure to address urban air pollution, and the Chinese government has launched a pilot subsidy scheme to improve its market penetration. We explored the environmental effects of subsidy on urban air pollution from the extensive and intensive margins and formulated a detailed panel dataset, covering 286 cities in China over the years 2006-2018. Moreover, the PSM-DID method and the instrumental strategy are used to confirm the robustness and validity of empirical results on the basis of comprehensive analysis of potential endogenous issues. The results indicate that the implementation of NEVs subsidy policy could significantly improve urban air quality in general, and as the subsidies scale increased by 1%, air pollution level will be reduced by about 0.15%. Then, from the perspective of the dynamic effect of subsidy, it not only has remarkable current environmental effect, but also an effective technology route in the long run. Simultaneously, compared with traditional intervention tools, subsidies enhance the diffusion of NEVs, reduce emissions of air pollutants while meeting residents' travel needs, and thus achieve incentive compatibility, which is the micro-foundation of environmental improvement. Nonetheless, we cannot simply believe the assertion that NEVs subsidy has positive environmental benefits to each region, as the non-clean generation of electricity in some areas will offset the potential environmental benefits. Additionally, the accelerated phase-out of NEVs subsidies at this stage may cause negative externalities of economy and environment, resulting the deadweight loss of industrial dividends accumulated in the early period. Based on above findings, governments should implement more flexible stimulus policies consistent with NEVs industry developments, rather than drastically reducing subsidies, while paying close attention to decarbonization of energy production stage.
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http://dx.doi.org/10.1016/j.scitotenv.2020.142232DOI Listing
February 2021

ADNP Upregulation Promotes Bladder Cancer Cell Proliferation the AKT Pathway.

Front Oncol 2020 9;10:491129. Epub 2020 Nov 9.

Department of Urology, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Hunan Cancer Hospital, Changsha, China.

Background: Activity-dependent neuroprotective protein (ADNP), which is involved in embryonic development and neurogenesis, has been proven to be upregulated in some human tumors. However, its role in bladder cancer (BC) has never been studied.

Objective: We aimed to investigate the mechanisms by which ADNP promotes the progression of BC.

Methods: ADNP expressions in BC cell lines and paired BC and adjacent normal tissues were measured by quantitative real-time PCR (qRT-PCR), Western blot, and immunohistochemistry. Colony formation, Cell Counting Kit-8 (CCK-8), trypan blue exclusion assay, flow cytometry, and nude mice tumorigenesis assay were performed to explore the effects of ADNP on growth of BC and . The impacts of ADNP on AKT signaling pathways were measured by Western blot.

Results: The expression of ADNP mRNA and protein was significantly upregulated in BC tissues compared with adjacent normal tissues. Immunohistochemical analysis of 221 BC and 51 adjacent normal tissue paraffin sections indicated that ADNP expression was significantly associated with histological classification and pathological T and N stages. Survival analysis revealed that patients with high ADNP expression have worse prognosis with respect to overall survival and progression-free disease. ADNP knockdown markedly delayed propagation of BC and the development of BC ADNP overexpression showed the opposite effect. In addition, ADNP can markedly promote G1-S cell cycle transition in BC cells. On the molecular level, we confirmed that ADNP mediated acceleration of G1-S transition was associated with activation of the AKT pathways in BC.

Conclusion: ADNP is overexpressed in BC and promotes BC growth partly through AKT pathways. ADNP is crucial in predicting the outcome of BC patients and may be a potential therapeutic target in BC.
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http://dx.doi.org/10.3389/fonc.2020.491129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680929PMC
November 2020

Mushroom Inonotus sanghuang alleviates experimental pulmonary fibrosis: Implications for therapy of pulmonary fibrosis.

Biomed Pharmacother 2021 Jan 14;133:110919. Epub 2020 Nov 14.

Institute of Infection and Immunity and Translational Medical Center, Huaihe Hospital of Henan University, Kaifeng, 475000, China. Electronic address:

Mushroom Inonotus sanghuang has been characterized as a traditional medicine in China and has pharmacological activities to treat inflammation, gastroenteric dysfunction, and cancer. Recently, we reported the impact of Inonotus sanghuang extract (ISE) from ethyl acetate fraction on bleomycin (BLM)-induced acute lung injury in mice. Here, we aimed to investigate ISE's impact on pulmonary fibrosis using in vivo and in vitro models and the underlying mechanisms. To evaluate pulmonary fibrosis, female C57BL/6 mice fed ISE (0% or 0.6% in diet) for 4 weeks were instilled intratracheally with BLM and then continued the same diet before the end of the experiment. A549 cells were used to evaluate the epithelial-mesenchymal transition (EMT). Feeding ISE improved BLM-treated mice's survival via decreasing lung infiltrating cells and fibrosis, followed by reducing hydroxyproline content, collagen deposition, and mesenchymal markers (α-SMA and vimentin) while increasing epithelial marker E-cadherin. ISE also suppressed the TGF-β expression, Smad2/3 phosphorylation, and EMT-related transcription factor Snail upon BLM instillation. Iin vitro study demonstrated that ISE inhibited TGF-β-induced EMT-like phenotype and cell behaviors, the expression of α-SMA and vimentin, and prevented E-cadherin reduction of A549 cells. Consistent with in vivo study, ISE abrogated p-Smad2/3, and Snail expression. Finally, the influence of ISE on EMT was not due to ISE toxicity. Our findings indicated that ISE effectively attenuated BLM-induced lung fibrosis. These ISE properties were thought to be involved in interfering TGF-β, Smad2/3 phosphorylation, and EMT process, suggesting that the material has the potential health benefits to improve lung fibrosis.
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http://dx.doi.org/10.1016/j.biopha.2020.110919DOI Listing
January 2021

Mid-infrared microfiber Bragg gratings.

Opt Lett 2020 Nov;45(22):6114-6117

We report mid-infrared (mid-IR) Bragg gratings fabricated on sub-wavelength-diameter chalcogenide glass (ChG) microfibers. ChG microfibers with diameters around 3 µm are tapered drawn from glass fibers, and the mid-IR microfiber Bragg gratings (mFBGs) are inscribed on microfibers using interference patterns of near bandgap light at a 532 nm wavelength. At a wavelength of about 4.5 µm, the mFBG has an extinction ratio of 15 dB and a positive photo-induced refractive index change of 2×10. The dependence of the grating formation on accumulated influence of exposure power density and time is investigated. The mid-IR mFBGs demonstrated here may be used as building blocks for micro-photonic circuits or devices in the mid-IR spectral range.
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http://dx.doi.org/10.1364/OL.403893DOI Listing
November 2020

Mushroom Modulates Host Immunological Response and Gut Microbiota in Mice.

Front Nutr 2020 8;7:144. Epub 2020 Oct 8.

Institute of Infection and Immunity and Translational Medical Center, Huaihe Hospital of Henan University, Kaifeng, China.

We aimed to determine the prebiotic impact of Mushroom (BI) on the host immune response and gut microbiota. Male C57BL/6 mice were fed a diet supplemented with 0, 1, or 2% BI for 4 wks. Compared to mice fed with a control diet (0% BI), mice fed with 1 or 2% BI had an increase of T cell proliferation from the spleen, but such change was not found between 1 and 2% BI treated mice. Also, BI at 2% increased the production of IL-2 of splenocytes stimulated with T-cell mitogens, but BI at 1 and 2% did not affect productions of other splenic-T cell cytokines including IL-4, IL-10, and IFN-γ. Interestingly, BI at 1 or 2% inhibited T cell proliferation of mesenteric lymph node (mLN) but this effect was not found between 1 and 2% BI treated mice. Furthermore, BI inhibited the production of IL-2 in anti-CD3/CD28-stimulated T cells from mLN in a dose-dependent manner. Meanwhile, BI at 2%, not 1% inhibited the production of IL-4, IL-10, and IFN-γ of mLN. Since BI at 2% produced a more significant effect on the immune response, we further used BI at 2% to evaluate the effect of BI on gut microbiota. Of note, BI reduced the diversity of gut microbiota and resulted in an increase of and abundance and the decrease of _, and abundance at the genus level. Finally, the correlation was observed between specific bacteria genera and the productions of T-cell cytokines from mesenteric lymphocytes: and correlated positively with IL-2, IL-4, IL-10, and IFN-γ; and correlated negatively with IL-2 and IL-4; correlated negatively with IFN-γ and IL-4 and and correlated negatively with IFN-γ. The specific role of each intestinal microbiota observed is still unclear, but BI might exert a prebiotic effect on gut microbiota by increasing the abundance of potentially beneficial bacteria (). This is helpful for further demonstrating the healthy-promotion mechanism of .
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http://dx.doi.org/10.3389/fnut.2020.00144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7578393PMC
October 2020

Discriminative Sparse Filtering for Multi-source Image Classification.

Sensors (Basel) 2020 Oct 16;20(20). Epub 2020 Oct 16.

School of Electronics and Information, Northwestern Polytechnical University, Xi'an 710072, China.

Distribution mismatch caused by various resolutions, backgrounds, etc. can be easily found in multi-sensor systems. Domain adaptation attempts to reduce such domain discrepancy by means of different measurements, e.g., maximum mean discrepancy (MMD). Despite their success, such methods often fail to guarantee the separability of learned representation. To tackle this issue, we put forward a novel approach to jointly learn both domain-shared and discriminative representations. Specifically, we model the feature discrimination explicitly for two domains. Alternating discriminant optimization is proposed to obtain discriminative features with an l2 constraint in labeled source domain and sparse filtering is introduced to capture the intrinsic structures exists in the unlabeled target domain. Finally, they are integrated in a unified framework along with MMD to align domains. Extensive experiments compared with state-of-the-art methods verify the effectiveness of our method on cross-domain tasks.
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http://dx.doi.org/10.3390/s20205868DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7594069PMC
October 2020

Different transmission dynamics of COVID-19 and influenza suggest the relative efficiency of isolation/quarantine and social distancing against COVID-19 in China.

Clin Infect Dis 2020 Oct 20. Epub 2020 Oct 20.

School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China.

Background: Non-pharmaceutical interventions (NPIs) against Coronavirus Disease 2019 (COVID-19) are vital to reducing the transmission risks. However, the relative efficiency of social distancing against COVID-19 remains controversial, since social distancing and isolation/quarantine were implemented almost at the same time in China.

Methods: In this study, surveillance data of COVID-19 and seasonal influenza in the year 2018-2020 were used to quantify the relative efficiency of NPIs against COVID-19 in China, since isolation/quarantine was not used for the influenza epidemics. Given that the relative age-dependent susceptibility to influenza and COVID-19 may vary, an age-structured Susceptible-Infected-Recovered model was built to explore the efficiency of social distancing against COVID-19 under different population susceptibility scenarios.

Results: The mean effective reproductive number, Rt, of COVID-19 before NPIs was 2.12 (95% confidential interval (CI): 2.02-2.21). By March 11, 2020, the overall reduction in Rt of COVID-19 was 66.1% (95% CI: 60.1%-71.2%). In the epidemiological year 2019/20, influenza transmissibility reduced by 34.6% (95% CI: 31.3%-38.2%) compared with that in the epidemiological year 2018/19. Under the observed contact patterns changes in China, social distancing had similar efficiency against COVID-19 in three different scenarios. By assuming same efficiency of social distancing against seasonal influenza and COVID-19 transmission, isolation/quarantine and social distancing could lead to a 48.1% (95% CI: 35.4%-58.1%) and 34.6% (95% CI: 31.3%-38.2%) reduction of the transmissibility of COVID-19.

Conclusions: Though isolation/quarantine is more effective than social distancing, given that typical basic reproductive number of COVID-19 is 2-3, isolation/quarantine alone could not contain the COVID-19 pandemic effectively in China.
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http://dx.doi.org/10.1093/cid/ciaa1584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7665384PMC
October 2020

Visible and near-infrared driven Yb/Tm co-doped InVO nanosheets for highly efficient photocatalytic applications.

Dalton Trans 2020 Oct;49(40):14030-14045

Research Institute of Photocatalysis, State Key Laboratory of Photocatalysis on Energy and Environment, Fuzhou University, Fuzhou, 350002, China.

To effectively enhance the utilization of clean sunlight energy, harvesting a large percentage of near infrared (NIR) light is significant. One of the commonly used effective methods for modifying semiconductors is by co-doping upconversion materials on semiconductors to heighten the photocatalytic efficiency. In this work, Yb3+/Tm3+ co-doped InVO4 nanosheets were synthesized by a facile hydrothermal path, and the crystal phases, morphologies, surface chemical compositions, as well as optical properties were characterized. Yb3+/Tm3+ co-doped InVO4 revealed significantly enhanced photoactivity towards chromium(vi) reduction and methyl orange oxidation under visible or NIR light irradiation. Furthermore, 5YT-IV presented the highest electrocatalytic performance and photocatalytic production of H2O2 under visible light irradiation, requiring low overpotential and low Tafel slope (390 mV dec-1) for hydrogen evolution reaction than that of the bare InVO4 (731 mV dec-1), and as well improved the yield of photocatalytic H2O2 production by about 3.5 times. This was primarily ascribed to intensive light absorption resulting from the benign upconversion energy transfer of Yb3+/Tm3+ and the boosted charge separation caused by the intermediate energy states. Moreover, the presence of h+ and ˙O2- as the main oxidative species played a significant role during the photocatalytic oxidation process of methyl orange and electrons played a decisive role in Cr(vi) reduction. This study provides a promising platform for efficiently utilizing the visible-NIR energy of sunlight in the field of photocatalytic H2O2 production and for alleviating environmental pollution in future.
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http://dx.doi.org/10.1039/d0dt02318cDOI Listing
October 2020