Publications by authors named "Yu Song"

845 Publications

The complete chloroplast genome sequence of Lodd.

Mitochondrial DNA B Resour 2021 Jun 7;6(7):1873-1874. Epub 2021 Jun 7.

Medical College, Qinghai University, Xining, PR China.

Lodd is an important traditional Chinese medicine, which is widely distributed in many areas of China. It has a variety of pharmacological activities and has been drunk as a tea for a long time. Therefore, it has great economic, research, and social value. However, no plastid genome has been reported to date. Here, we report species of this genus complete chloroplast genome of Lodd. The chloroplast genome of Lodd is found to be 152,900 bp in length with 37.24% GC contents. The cp genome sequences contained 130 genes, including 84 mRNA genes, 37 tRNA, eight rRNA genes, and one pseudogenes, respectively. A phylogenetic tree reconstructed by 42 chloroplast genomes reveals that Lodd is most related with . The complete chloroplast genome of these plants will be benefit for studies on the general characteristics and evolution of the Potentilla family genome.
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http://dx.doi.org/10.1080/23802359.2021.1934141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189135PMC
June 2021

Rectangular 3-snip punctoplasty versus punch punctoplasty with silicone intubation for acquired external punctal stenosis: a prospective randomized comparative study.

Int J Ophthalmol 2021 18;14(6):849-854. Epub 2021 Jun 18.

Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.

Aim: To evaluate the effectiveness of rectangular 3-snip punctoplasty versus punch punctoplasty Kelly punch with silicone intubation for the management of acquired external punctal stenosis (AEPS).

Methods: A prospective, randomized, comparative study was performed on 123 eyes of 94 patients with AEPS. Patients were recruited into either group of rectangular 3-snip punctoplasty (group A) or group of punch punctoplasty with silicone intubation (group B). Outcomes measured were Munk score, grade of punctal stenosis, fluorescein dye disappearance time test (FDDT) and tear meniscus height (TMH) 6 and 12mo after surgery.

Results: Twelve months after surgery, Munk score, FDDT and TMH significantly decreased in both groups compared with the baseline (all <0.05), and grade of punctal stenosis increased significantly (<0.05). The grade of punctal stenosis, Munk score, FDDT and TMH were better in group B compared with group A at 6 or 12mo (all <0.05). There was a positive correlation between TMH and Munk score (=0.655, <0.001). At the last followed-up, anatomical success was noted in 96.7% eyes in group A and 98.4% eyes in group B (=0.613).

Conclusion: Punch punctoplasty Kelly punch with silicone intubation achieves better outcomes than rectangular 3-snip punctoplasty. The new technique is a simple, minimally invasive, with high anatomical and functional success in patients with AEPS.
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http://dx.doi.org/10.18240/ijo.2021.06.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165618PMC
June 2021

TiN Paper for Ultrafast-Charging Supercapacitors.

Nanomicro Lett 2019 Dec 10;12(1). Epub 2019 Dec 10.

Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA, 95064, USA.

Ultrafast-charging energy storage devices are attractive for powering personal electronics and electric vehicles. Most ultrafast-charging devices are made of carbonaceous materials such as chemically converted graphene and carbon nanotubes. Yet, their relatively low electrical conductivity may restrict their performance at ultrahigh charging rate. Here, we report the fabrication of a porous titanium nitride (TiN) paper as an alternative electrode material for ultrafast-charging devices. The TiN paper shows an excellent conductivity of 3.67 × 10 S m, which is considerably higher than most carbon-based electrodes. The paper-like structure also contains a combination of large pores between interconnected nanobelts and mesopores within the nanobelts. This unique electrode enables fast charging by simultaneously providing efficient ion diffusion and electron transport. The supercapacitors (SCs) made of TiN paper enable charging/discharging at an ultrahigh scan rate of 100 V s in a wide voltage window of 1.5 V in NaSO neutral electrolyte. It has an outstanding response time with a characteristic time constant of 4 ms. Significantly, the TiN paper-based SCs also show zero capacitance loss after 200,000 cycles, which is much better than the stability performance reported for other metal nitride SCs. Furthermore, the device shows great promise in scalability. The filtration method enables good control of the thickness and mass loading of TiN electrodes and devices.
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http://dx.doi.org/10.1007/s40820-019-0340-7DOI Listing
December 2019

A Review on Nano-/Microstructured Materials Constructed by Electrochemical Technologies for Supercapacitors.

Nanomicro Lett 2020 May 30;12(1):118. Epub 2020 May 30.

Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA, 24061, USA.

The article reviews the recent progress of electrochemical techniques on synthesizing nano-/microstructures as supercapacitor electrodes. With a history of more than a century, electrochemical techniques have evolved from metal plating since their inception to versatile synthesis tools for electrochemically active materials of diverse morphologies, compositions, and functions. The review begins with tutorials on the operating mechanisms of five commonly used electrochemical techniques, including cyclic voltammetry, potentiostatic deposition, galvanostatic deposition, pulse deposition, and electrophoretic deposition, followed by thorough surveys of the nano-/microstructured materials synthesized electrochemically. Specifically, representative synthesis mechanisms and the state-of-the-art electrochemical performances of exfoliated graphene, conducting polymers, metal oxides, metal sulfides, and their composites are surveyed. The article concludes with summaries of the unique merits, potential challenges, and associated opportunities of electrochemical synthesis techniques for electrode materials in supercapacitors.
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http://dx.doi.org/10.1007/s40820-020-00451-zDOI Listing
May 2020

Well-demarcated erythematous plaque on the arm.

Indian J Dermatol Venereol Leprol 2021 May 31:1-3. Epub 2021 May 31.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.25259/IJDVL_608_19DOI Listing
May 2021

Research progress of dual inhibitors targeting crosstalk between histone epigenetic modulators for cancer therapy.

Eur J Med Chem 2021 Jun 1;222:113588. Epub 2021 Jun 1.

School of Pharmacy, Xinxiang Medical University, 453003, Xinxiang, Henan Province, PR China. Electronic address:

Abnormal epigenetics is a critical hallmark of human cancers. Anticancer drug discovery directed at histone epigenetic modulators has gained impressive advances with six drugs available for cancer therapy and numerous other candidates undergoing clinical trials. However, limited therapeutic profile, drug resistance, narrow safety margin, and dose-limiting toxicities pose intractable challenges for their clinical utility. Because histone epigenetic modulators undergo intricate crosstalk and act cooperatively to shape an aberrant epigenetic profile, co-targeting histone epigenetic modulators with a different mechanism of action has rapidly emerged as an attractive strategy to overcome the limitations faced by the single-target epigenetic inhibitors. In this review, we summarize in detail the crosstalk of histone epigenetic modulators in regulating gene transcription and the progress of dual epigenetic inhibitors targeting this crosstalk.
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http://dx.doi.org/10.1016/j.ejmech.2021.113588DOI Listing
June 2021

Loco-regional therapy and the risk of breast cancer-related lymphedema: a systematic review and meta-analysis.

Breast Cancer 2021 Jun 9. Epub 2021 Jun 9.

Department of Breast Disease, Peking Union Medical College Hospital, Peking Union Medical College, 1 Shuaifuyuan, Wangfujing, Beijing, 100730, China.

Background: This meta-analysis was designed to assess the association between two loco-regional therapies, regional nodal irradiation (RNI) and axillary lymph node dissection (ALND), and breast cancer-related lymphoedema (BCRL).

Methods: We searched PubMed, Science Direct, Embase, and BMJ databases for clinical studies published between January 1, 2010 and January 1, 2020, which assessed risk factors and incidence/prevalence of BCRL. Two investigators independently selected articles to extract relative data and calculate corresponding exact binomial 95% confidence intervals (CIs). In total, 93 articles were reviewed, from which 19 studies were selected. The extracted data were pooled using a random-effects mixed model.

Results: The incidence of lymphedema in the selected studies ranged from 3% to 36.7%, with a pooled incidence of 14.29% (95% CI 13.79-14.79). The summary odds ratio/risk ratio (OR/RR) of ALND vs. no-ALND was 3.67 (95% CI 2.25-5.98) with a heterogeneity (I) of 81% (P < 0.00001). After excluding the studies with an abnormally high risk of lymphedema from self-reporting, the summary hazard ratio (HR) was 2.99 (95% CI 2.44-3.66) with no heterogeneity (I = 0%, P = 0.83). The summary OR/RR of patients with vs. without radiotherapy (RT) was 1.82 (95% CI 0.92-3.59), but the RR of RT to breast/chest vs. both axillary and supraclavicular areas was 2.66 (95% CI 0.73-9.70).

Conclusion: Regional nodal irradiation has a significantly higher risk for developing lymphedema than irradiation of the breast/chest wall. Axillary dissection and axillary RT have a similar risk for early-onset of breast cancer-related lymphoedema, although the risk trends higher for axillary dissection.
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http://dx.doi.org/10.1007/s12282-021-01263-8DOI Listing
June 2021

Longitudinal assessments of strength and dynamic balance from pre-injury baseline to 3 and 4 months after labrum repairs in collegiate athletes.

Physiother Theory Pract 2021 Jun 7:1-9. Epub 2021 Jun 7.

Division of Kinesiology and Health, University of Wyoming, 1000 E. University AvE., Laramie, WY, USA.

There is a lack of quantitative assessments of athletes' functional strength and dynamic balance following labrum repairs. To compare the upper extremity strength and dynamic balance among pre-injury baseline and approximately 3 and 4 months after labrum surgeries in collegiate athletes to identify critical values to inform rehabilitation. Fifteen male and one female collegiate athletes between 18 and 22 years old were tested at pre-injury baseline (n = 14) and 2.7 (n = 16) and 3.8 months (n = 12) after labrum surgeries. Strength was assessed using the peak forces produced in a maximal push-up test. Dynamic balance was assessed using the reaching distances in a reaching test. The injured side's peak forces significantly decreased from the baseline to the 3-month post-surgery and then significantly increased between the 3-month and 4-month post-surgery assessments but remained significantly less at the 4-month post-surgery compared to the baseline (p ≤ 0.024; Cohen's d ≥ 0.75). Peak force asymmetries were greater at the 3-month and 4-month post-surgery assessments than the baseline (p ≤ 0.005; Cohen's d ≥ 1.02). With a relatively small sample size, the results support the use of objective functional assessments for rehabilitation and return-to-play decisions among collegiate athletes following labrum repairs.
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http://dx.doi.org/10.1080/09593985.2021.1934925DOI Listing
June 2021

Pathogenic mechanism, detection methods and clinical significance of group B .

Future Microbiol 2021 Jun 8;16:671-685. Epub 2021 Jun 8.

Department of Central Lab, Weihai Municipal Hospital, Cheeloo College of Medicine, Shandong University, Weihai, Shandong, 264200, PR China.

Group B (GBS) is the main pathogen of perinatal infection. It can lead to adverse pregnancy, maternal infection, premature delivery, abortion, stillbirth and a series of adverse maternal and infant outcomes such as neonatal sepsis, meningitis or pneumonia during delivery. In order to reduce the infection of perinatal pregnant and the adverse pregnancy outcome, more attention should be paid in the clinical practice, screening efforts, universal detection of GBS infection for pregnant women and preventive treatment for the possible mother infant infection. In this study, the biological characteristics, immunophenotype, major pathogenic mechanism, laboratory test methods and clinical significance of GBS are summarized.
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http://dx.doi.org/10.2217/fmb-2020-0189DOI Listing
June 2021

Challenges in establishing a strong family medicine system in China.

Fam Pract 2021 Jun 7. Epub 2021 Jun 7.

Psychosomatic Medical Center, The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China.

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http://dx.doi.org/10.1093/fampra/cmab059DOI Listing
June 2021

Pyrolysis and Combustion Chemistry of Pyrrole, a Reference Component for Bio-oil Surrogates: Jet-Stirred Reactor Experiments and Kinetic Modeling.

Energy Fuels 2021 May 2;35(9):7265-7284. Epub 2021 Mar 2.

Laboratoire Réactions et Génie des Procédés, CNRS, Université de Lorraine, ENSIC, 54001 Nancy Cedex, France.

Fast-pyrolysis bio-oils (FPBOs) obtained from lignocellulosic biomass are gaining attention as sustainable fuels for various applications, including the transport sector and power production. A significant fraction of bio-oils is constituted by nitrogen-containing compounds (N fuels) that should be considered when developing surrogate models for FPBOs. Moreover, the content of N fuels in FPBOs is expected to strongly contribute to the production of nitrogen oxides (NO ) directly from fuel-bound nitrogen (fuel NO ), in addition to the thermal NO formation pathways typical of high-temperature combustion conditions. This work investigates the pyrolysis and combustion chemistry of pyrrole (CHN), a candidate reference fuel component for FPBO surrogate models. Speciation measurements in an atmospheric pressure jet-stirred reactor have been performed for both pyrolysis and oxidation conditions. Pyrolysis experiments have been performed for 1% pyrrole/helium mixtures over the temperature range = 925-1200 K. Oxidation experiments were carried out for 1% pyrrole/oxygen/helium mixtures at three equivalence ratios (φ = 0.5, 1.0, and 2.0) over the temperature range = 700-1200 K. These new data significantly extend the number of experimental targets for kinetic model validation available at present for pyrrole combustion. After a thorough revision of previous theoretical and kinetic modeling studies, a preliminary kinetic model is developed and validated by means of comparison to new experimental data and those previously reported in the literature. The rate of production and sensitivity analyses highlight important pathways deserving further investigations for a better understanding of pyrrole and, more in general, N fuel combustion chemistry. A critical discussion on experimental challenges to be faced when dealing with pyrrole is also reported, encouraging further experimental investigation with advanced diagnostics.
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http://dx.doi.org/10.1021/acs.energyfuels.0c03874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8161689PMC
May 2021

Production of IL-31 in CD45ROCLAH4R T Cells in Atopic Dermatitis.

J Clin Med 2021 May 4;10(9). Epub 2021 May 4.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Korea.

IL-31 is involved in pruritus in atopic dermatitis (AD) and the pathogenesis of AD. However, the mechanism of IL-31 production is not fully understood. We sought to investigate the association between CD45ROCLAH4R T cells and IL-31 production. Immunofluorescence studies were performed retrospectively on punch-biopsy specimens from five people with AD and three healthy controls. In addition, blood samples were collected prospectively from eight patients with AD and eight healthy controls for sorting CD45ROCLAH4R T cells. There was no overlap of patients between the biopsy group and the blood sampling group. Sorted cells were stimulated with 4-methylhistamine (4MH), and the level of IL-31 was measured by an enzyme-linked immunosorbent assay. Immunofluorescence showed co-localization of H4R and IL-31 in lesional AD skin but not in normal skin of healthy controls. The proportion of CLAH4R T cells among CD3CD45RO lymphocytes was 18.3 ± 6.2% in patients with AD and 11.2 ± 7.6% in healthy controls. In the AD group, production of IL-31 by CD45ROCLAH4R T cells increased from 32.4 ± 13.3 pg/mL to 47.5 ± 18.7 pg/mL by 4MH stimulation after 24 h ( < 0.001). However, in the control group, production of IL-31 was 20.1 ± 10.6 pg/mL without and 22.1 ± 9.3 pg/mL with 4MH stimulation ( > 0.05). According to our study, CD45ROCLAH4R T cells are an important source of IL-31 in AD, and may be a target for treatment of IL-31-induced pruritus.
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http://dx.doi.org/10.3390/jcm10091976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124489PMC
May 2021

The energy storage behavior of a phosphate-based cathode material in rechargeable zinc batteries.

Chem Commun (Camb) 2021 Jun 1. Epub 2021 Jun 1.

Department of Chemistry, Northeastern University, Shenyang, 110819, China.

The energy storage behavior of the Li3V2(PO4)3 cathode in zinc batteries is evaluated. The dissolution or decomposition into vanadium oxide in aqueous electrolytes is revealed. Using the optimal combination of water and acetonitrile solvents in electrolyte, those processes are effectively prevented without sacrificing the Zn2+ de/insertion kinetics. Further investigation demonstrates a water induced phase transformation into a VOPO4 type structure, which is still a polyanion material and preserves the high voltage. It delivers 128 mA h g-1 capacity at 1C with 1.45 V discharge voltage, and 87 mA h g-1 capacity is retained at 10C. A stable cycling is obtained for 1000 cycles.
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http://dx.doi.org/10.1039/d1cc00584gDOI Listing
June 2021

Release of inhalable particles and viable microbes to the air during packaging peeling: Emission profiles and mechanisms.

Environ Pollut 2021 May 11;285:117338. Epub 2021 May 11.

Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Qingdao, 266237, China. Electronic address:

Packaging is necessary for preserving and delivering products and has significant impacts on human health and the environment. Particle matter (PM) may be released from packages and transferred to the air during a typical peeling process, but little is known about this package-to-air migration route of particles. Here, we investigated the emission profiles of total and biological particles, and the horizontal and vertical dispersion abilities and community structure of viable microbes released from packaging to the air by peeling. The results revealed that a lot of inhalable particles and viable microbes were released from package to the air in different migration directions, and this migration can be regulated by several factors including package material, effective peeling area, peeling speed and angles, as well as the characteristics of the migrant itself. Dispersal of package-borne viable microbes provides direct evidence that viable microbes, including pathogens, can survive the aerosolization caused by peeling and be transferred to air over different distances while remaining alive. Based on the experimental data and visual proof in movies, we speculate that nonbiological particles are package fibers fractured and released to air by the external peeling force exerted on the package and that microbe dispersal is attributed to surface-borne microbe suspension by vibration caused by the peeling force. This investigation provides new information that aerosolized particles can deliver package-borne substances and viable microbes from packaging to the ambient environment, motivating further studies to characterize the health effects of such aerosolized particles and the geographic migration of microbes via packaging.
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http://dx.doi.org/10.1016/j.envpol.2021.117338DOI Listing
May 2021

Identify dominant dimensions of 3D hand shapes using statistical shape model and deep neural network.

Appl Ergon 2021 May 25;96:103462. Epub 2021 May 25.

Faculty of Industrial Design Engineering, Delft University of Technology, Delft, South Holland, 2628CE, the Netherlands.

Hand anthropometry is one of the fundamentals of ergonomic research and product design. Many studies have been conducted to analyze the hand dimensions among different populations, however, the definitions and the numbers of those dimensions were usually selected based on the experience of the researchers and the available equipment. Few studies explored the importance of each hand dimension regarding the 3D shape of the hand. In this paper, we aim to identify the dominant dimensions that influence the hand shape variability while considering the stability of the measurements in practice. A novel four-step research method was proposed where in the first step, based on literature study, we defined 58 landmarks and 53 dimensions for the exploration. In the second step, 80,000 virtual hand models, each had the associated 53 dimensions, were augmented by changing the weights of Principle Components (PCs) of a statistical shape model (SSM). Deep neural networks (DNNs) were used to establish the inverse relationships from the dimensions to the weight of each PC of the hand SSM. Using the structured sparsity learning method, we identified 21 dominant dimensions that represent 90% of the variance of the hand shape. In the third step, two different manual measuring methods were used to evaluate the stability of the measurements in practice. Finally, we selected 16 dominant dimensions with lower measurement variance by synthesizing the findings in Step 2 and 3. It was concluded that the recognized 21 dominant dimensions can be treated as the reference dimensions for anthropometric study and using the selected 16 dominant dimensions with lower measurement variance, ergonomists are able to generate a 3D hand model based on simple measurement tools with an accuracy of 5.9 mm. Though the accuracy is limited, the efforts are minimum, and the results can be used as an indicator in the early stage of research/design.
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http://dx.doi.org/10.1016/j.apergo.2021.103462DOI Listing
May 2021

Plastid NDH Pseudogenization and Gene Loss in a Recently Derived Lineage from the Largest Hemiparasitic Plant Genus Pedicularis (Orobanchaceae).

Plant Cell Physiol 2021 May 28. Epub 2021 May 28.

Center for Integrative Conservation, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan 666303, China.

The plastid genome (plastome) is highly conserved in both gene order and content and has a lower mutation rate than the nuclear genome. However, the plastome is more variable in heterotrophic plants. To date, most such studies have investigated just a few species or only holoheterotrophic groups, and few have examined plastome evolution in recently derived lineages at an early stage of transition from autotrophy to heterotrophy. In this study, we investigated the evolutionary dynamics of plastomes in the monophyletic and recently derived Pedicularis sect. Cyathophora (Orobanchaceae) . We obtained 22 new plastomes, 13 from the six recognized species of section Cyathophora, six from hemiparasitic relatives, and three from autotrophic relatives. Comparative analyses of gene content, plastome structure, and selection pressure showed dramatic differences among species in section Cyathophora and in Pedicularis as a whole. In comparison with autotrophic relatives and other Pedicularis spp., we found that the IR region in section Cyathophora had expansions to the SSC region, with a large expansion event and two independent contraction events. Moreover, NDH, accD, and ccsA have lost function multiple times with the function of accD being replaced by nuclear copies of an accD-like gene in Pedicularis spp. The ccsA and ndhG genes may have evolved under selection in association with IR expansion/contraction events. This study is the first to report high plastome variation in a recently derived lineage of hemiparasitic plants, and therefore provides evidence for plastome evolution in the transition from autotrophy to heterotrophy.
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http://dx.doi.org/10.1093/pcp/pcab074DOI Listing
May 2021

Risk Score for Predicting Dysphagia in Patients After Neurosurgery: A Prospective Observational Trial.

Front Neurol 2021 11;12:605687. Epub 2021 May 11.

Department of Nursing, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Acquired dysphagia is common in patients with tracheal intubation and neurological disease, leading to increased mortality. This study aimed to ascertain the risk factors and develop a prediction model for acquired dysphagia in patients after neurosurgery. A multicenter prospective observational study was performed on 293 patients who underwent neurosurgery. A standardized swallowing assessment was performed bedside within 24 h of extubation, and logistic regression analysis with a best subset selection strategy was performed to select predictors. A nomogram model was then established and verified. The incidence of acquired dysphagia in our study was 23.2% (68/293). Among the variables, days of neurointensive care unit (NICU) stay [odds ratio (OR), 1.433; 95% confidence interval (CI), 1.141-1.882; = 0.005], tracheal intubation duration (OR, 1.021; CI, 1.001-1.062; = 0.175), use of a nasogastric feeding tube (OR, 9.131; CI, 1.364-62.289; = 0.021), and Acute Physiology and Chronic Health Evaluation (APACHE)-II C score (OR, 1.709; CI, 1.421-2.148; < 0.001) were selected as risk predictors for dysphagia and included in the nomogram model. The area under the receiver operating characteristic curve was 0.980 (CI, 0.965-0.996) in the training set and 0.971 (0.937-1) in the validation set, with Brier scores of 0.045 and 0.056, respectively. Patients who stay longer in the NICU, have a longer duration of tracheal intubation, require a nasogastric feeding tube, and have higher APACHE-II C scores after neurosurgery are likely to develop dysphagia. This developed model is a convenient and efficient tool for predicting the development of dysphagia.
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http://dx.doi.org/10.3389/fneur.2021.605687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144441PMC
May 2021

Divergence of stem biomechanics and hydraulics between lianas and trees.

AoB Plants 2021 Jun 8;13(3):plab016. Epub 2021 Apr 8.

CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla, Yunnan 666303, China.

Liana abundance and biomass are increasing in neotropical and Asian tropical seasonal forests over the past decades. Stem mechanical properties and hydraulic traits influence the growth and survival of plants, yet the differences in stem mechanical and hydraulic performance between congeneric lianas and trees remain poorly understood. Here, we measured 11 stem mechanical and hydraulic traits for 10 liana species and 10 tree species from grown in a tropical common garden. Our results showed that lianas possessed lower stem mechanical strength as indicated by both modulus of elasticity and modulus of rupture, and higher stem potential hydraulic conductivity than congeneric trees. Such divergence was mainly attributed to the differentiation in liana and tree life forms. Whether the phylogenetic effect was considered or not, mechanical strength was positively correlated with wood density, vessel conduit wall reinforcement and sapwood content across species. Results of principle component analysis showed that traits related to mechanical safety and hydraulic efficiency were loaded in the opposite direction, suggesting a trade-off between biomechanics and hydraulics. Our results provide evidence for obvious differentiation in mechanical demand and hydraulic efficiency between congeneric lianas and trees.
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http://dx.doi.org/10.1093/aobpla/plab016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114228PMC
June 2021

Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis).

Dev Comp Immunol 2021 Sep 15;122:104135. Epub 2021 May 15.

Wuxi Fisheries College, Nanjing Agricultural University, Wuxi, 214081, China; Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Key Laboratory for Sustainable Development of Marine Fisheries, Ministry of Agriculture, Qingdao, 266071, China; Laboratory for Marine Fisheries Science and Food Production Processes, Pilot National Laboratory for Marine Science and Technology(Qingdao), Qingdao, 266237, China; Shandong Key Laboratory of Marine Fisheries Biotechnology and Genetic Breeding, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, 266071, China. Electronic address:

The pore-forming protein perforin is one of the effectors of cell-mediated killing via the granule exocytosis pathway. In this study, a genome-wide association study was conducted in Vibrio harveyi disease-resistant and disease-susceptible families of half smooth tongue sole (Cynoglossus semilaevis) to determine the genes accounting for host resistance, and a perforin homologue was identified, designated perforin-1 like (CsPRF1l). The full-length cDNA of CsPRF1l is 1835 bp, and encodes 514 amino acids. The CsPRF1l gene consists of 10 exons and 9 introns, spanning approximately 7 kb. The amino acid sequence of CsPRF1l shows 60.35, 54.03, 41.92, and 34.17% identities to Morone saxatilis PRF1l, Oryzias melastigma PRF1l, Danio rerio PRF1.5 and Homo sapiens PRF, respectively. Sequence analysis revealed the presence of membrane attack complex/perforin (MACPF) and C2 domains in CsPRF1l. Quantitative real-time PCR showed that CsPRF1l presented a higher intestinal expression level in disease-resistant families than in susceptible families. Tissue expression pattern analysis showed that CsPRF1l is present in most of the tested tissues and highly expressed in the intestine, brain, stomach and gills. After challenge with V. harveyi, CsPRF1l mRNA was markedly upregulated in the liver, spleen, kidney, intestine, gills and skin. In addition, the recombinant CsPRF1l protein exhibited obvious antimicrobial activity against V. harveyi in vitro and in a zebrafish model. Collectively, these data indicate that CsPRF1l modulates host immune defense against V. harveyi invasion and provide clues about the efficacy of rCsPRF1l in fish that will give rise to useful therapeutic applications for V. harveyi infection in C. semilaevis.
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http://dx.doi.org/10.1016/j.dci.2021.104135DOI Listing
September 2021

Fumonisin B1 triggers carcinogenesis via HDAC/PI3K/Akt signalling pathway in human esophageal epithelial cells.

Sci Total Environ 2021 Sep 30;787:147405. Epub 2021 Apr 30.

SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address:

Fumonisin B1 (FB1) is a contaminant that commonly present in the global environment, especially in food and feed. Epidemiologic studies have shown that esophageal cancer is associated with fumonisin toxicity. However, the molecular mechanism of FB1-induced esophageal cancer is unclear. In this research, the molecular mechanism of FB1-induced cell carcinogenesis in human esophageal epithelial cells line (HEEC) was explored. We found that FB1 (0.3125-5 μM) could promote cell proliferation, and the same phenomenon was found in a 3D cell model. FB1 could also accelerate cell migration. The expression levels of DNA damage markers were significantly increased after FB1 exposure. Meanwhile, the expression levels of cell cycle-regulated proteins and cancer-related genes were abnormal. Furthermore, FB1 significantly upregulated the histone deacetylase (HDAC) expression and activated the phosphoinositide 3 kinase (PI3K)/protein kinase B (Akt) signalling pathway. The HDAC inhibitor trichostatin A (TSA) could repressed FB1-promoted cell proliferation and abnormal phenomenon induced by FB1. Moreover, myriocin (ISP-1) could relieve FB1-enhanced HDAC expression and cell proliferation, which implied that ISP-1 may be used to block the fumonisin toxicity in the future. Our findings suggested that the HDAC/PI3K/Akt signalling pathway is a novel mechanism for FB1-induced cell carcinogenesis in HEEC and provided new ideas for the prevention and control of fumonisin toxicity, subsequently avoiding adverse effects on the ecosystem and human health.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147405DOI Listing
September 2021

Serum nuclear factor IB as a novel and noninvasive indicator in the diagnosis of secondary hyperparathyroidism.

J Clin Lab Anal 2021 Jun 15;35(6):e23787. Epub 2021 May 15.

Department of Nephrology, The First People's Hospital of Xiaoshan District, Hangzhou, China.

Background: Chronic renal failure (CRF) referred to chronic progressive renal parenchymal damage caused by various causes, with metabolite retention and imbalance of water, electrolyte, and acid-base balance as the main clinical manifestations. Secondary hyperparathyroidism (sHPT) was a common complication in maintenance hemodialysis patients with CRF. Nuclear factor IB (NFIB) was a newly found tumor suppressor gene in various cancers. The present study aimed to illustrate the role of NFIB in sHPT clinical diagnosis and treatment response.

Methods: A retrospective, case-control study, including 189 patients with sHPT and 106 CRF patients without sHPT, compared with 95 controls. Serum NFIB and 1,25(OH) D levels were measured by RT-qPCR and ELISAs, respectively. ROC analysis was conducted to verify the diagnostic value of NFIB in sHPT. Spearman's correlation analysis was conducted to verify the association between NFIB and bone mineral density (BMD) scores. After 6 months of treatment, the variance of NFIB and 1,25(OH) D in different groups was recorded.

Results: The expression of NFIB was significantly lower in serum samples from sHPT and non-sHPT CRF patients, compared to controls. Clinicopathological information verified sHPT was associated with NFIB, parathyroid hormone (PTH), serum calcium, serum phosphorus, time of dialysis, and serum 1,25(OH) D levels. Spearman's correlation analysis illustrated the positive correlation between NFIB levels and BMD scores. At receiver operator characteristic (ROC) curve analysis, the cutoff of 1.6508 for NFIB was able to identify patients with sHPT from healthy controls; meanwhile, NFIB could also discriminate sHPT among CRF patients as well (cutoff = 1.4741). Furthermore, we found that during 6 months of treatment, NFIB levels were gradually increased, while PTH and serum P levels were decreased.

Conclusions: Serum NFIB was a highly accurate tool to identify sHPT from healthy controls and CRF patients. Due to its simplicity, specificity, and sensitivity, this candidate can be proposed as a first-line examination in the diagnostic workup in sHPT.
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http://dx.doi.org/10.1002/jcla.23787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183937PMC
June 2021

Michelson interferometer based phase demodulation for stable time transfer over 1556 km fiber links.

Opt Express 2021 May;29(10):14505-14512

Time transfer based on phase modulation schemes has attracted extensive attention in recent years. We propose and experimentally demonstrate an adjustable and stable Michelson interferometer (MI) with a DC phase tracking algorithm for two-way time transfer. Time signal with one pulse per second (1 PPS) is loaded on an optical carrier modulated in phase and demodulated by a Michelson interferometer. The whole compact and cost-effective demodulator is symmetrical with a single coupler to split and recombine optical waves, flexible with one photodetector and a bias tee to separate the DC signal and recovery pulses and stable with a phase modulator to compensate for the drift-phase noise. We show the implementation of modulation and demodulation of the time signal and obtain the stability of 2.31 × 10 at 1000 s averaging time. We then demonstrate two-way time transfer over 1556 km lab fibers. The experimental result shows time interval stability of 1 PPS with 5.62 × 10 at 1000 s averaging time. It has the potential to transfer time signals in long-distance fiber optic links.
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http://dx.doi.org/10.1364/OE.420712DOI Listing
May 2021

Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration.

Biomaterials 2021 07 6;274:120850. Epub 2021 May 6.

Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Extracellular vesicles (EVs) are extracellular nanovesicles that deliver diverse cargoes to the cell and participate in cell communication. Mesenchymal stem cell (MSCs)-derived EVs are considered a therapeutic approach in musculoskeletal degenerative diseases, including intervertebral disc degeneration. However, limited production yield and unstable quality have impeded the clinical application of EVs. In the present study, it is indicated that metformin promotes EVs release and alters the protein profile of EVs. Metformin enhances EVs production via an autophagy-related pathway, concomitantly with the phosphorylation of synaptosome-associated protein 29. More than quantity, quality of MSCs-derived EVs is influenced by metformin treatment. Proteomics analysis reveals that metformin increases the protein content of EVs involved in cell growth. It is shown that EVs derived from metformin-treated MSCs ameliorate intervertebral disc cells senescence in vitro and in vivo. Collectively, these findings demonstrate the great promise of metformin in EVs-based intervertebral disc regeneration.
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http://dx.doi.org/10.1016/j.biomaterials.2021.120850DOI Listing
July 2021

Combining External Medical Knowledge for Improving Obstetric Intelligent Diagnosis: Model Development and Validation.

JMIR Med Inform 2021 May 10;9(5):e25304. Epub 2021 May 10.

The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Data-driven medical health information processing has become a new development trend in obstetrics. Electronic medical records (EMRs) are the basis of evidence-based medicine and an important information source for intelligent diagnosis. To obtain diagnostic results, doctors combine clinical experience and medical knowledge in their diagnosis process. External medical knowledge provides strong support for diagnosis. Therefore, it is worth studying how to make full use of EMRs and medical knowledge in intelligent diagnosis.

Objective: This study aims to improve the performance of intelligent diagnosis in EMRs by combining medical knowledge.

Methods: As an EMR usually contains multiple types of diagnostic results, the intelligent diagnosis can be treated as a multilabel classification task. We propose a novel neural network knowledge-aware hierarchical diagnosis model (KHDM) in which Chinese obstetric EMRs and external medical knowledge can be synchronously and effectively used for intelligent diagnostics. In KHDM, EMRs and external knowledge documents are integrated by the attention mechanism contained in the hierarchical deep learning framework. In this way, we enrich the language model with curated knowledge documents, combining the advantages of both to make a knowledge-aware diagnosis.

Results: We evaluate our model on a real-world Chinese obstetric EMR dataset and showed that KHDM achieves an accuracy of 0.8929, which exceeds that of the most advanced classification benchmark methods. We also verified the model's interpretability advantage.

Conclusions: In this paper, an improved model combining medical knowledge and an attention mechanism is proposed, based on the problem of diversity of diagnostic results in Chinese EMRs. KHDM can effectively integrate domain knowledge to greatly improve the accuracy of diagnosis.
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http://dx.doi.org/10.2196/25304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145091PMC
May 2021

LncRNA PINK1-AS promotes Gαi1-driven gastric cancer tumorigenesis by sponging microRNA-200a.

Oncogene 2021 Jun 6;40(22):3826-3844. Epub 2021 May 6.

Center of Translational Medicine, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, China.

Gastric cancer (GC) is one of the leading causes of human mortality around the world. We have previously shown that Gαi1 (the inhibitory subunit 1 of the heterotrimeric guanine nucleotide-binding protein) recruitment to ligand-activated receptor tyrosine kinases (RTKs) is essential for signaling. Testing its role in GC cancer-promoting functions, we found that Gαi1 is upregulated in human GC, correlating with poor overall survival. In established and primary human GC cells, Gαi1 shRNA (small hairpin RNA) or knockout produced significant anti-GC cell activity, proliferation and migration was inhibited, and apoptosis was activated. Conversely, ectopic Gαi1 overexpression promoted proliferation and migration of GC cells in vitro. By examining the tumor-suppressive miRNA microRNA-200a (miR-200a), we found that miR-200a directly silenced Gαi1 to induce anti-GC cell activity. The expression of miR-200a was downregulated in human GC, correlating with upregulation of a novel miR-200a-targeting long non-coding RNA (LncRNA), PINK1 (PTEN Induced Kinase 1)-AS. RNA immunoprecipitation, RNA-pull down, and RNA fluorescence in situ hybridization assays confirmed that PINK1-AS directly binds to miR-200a. Silencing PINK1-AS in GC cells led to miR-200a accumulation, Gαi1 downregulation, and inhibition of GC cell progression in vitro, whereas PINK1-AS upregulation produced the converse results. Significantly, anti-GC cell activity induced by PINK1-AS shRNA was ameliorated by the expression of miR-200a antisense or the 3'-UTR (untranslated region)-depleted Gαi1. In vivo, the growth of subcutaneous MGC-803 xenografts in nude mice was inhibited by PINK1-AS shRNA, but accelerated by PINK1-AS overexpression. Patient-derived GC xenograft growth in nude mice was largely inhibited after intratumoral injection of PINK1-AS shRNA lentivirus. In conclusion, PINK1-AS promotes Gαi1-driven GC progression by sponging miR-200a.
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http://dx.doi.org/10.1038/s41388-021-01812-7DOI Listing
June 2021

Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer.

Eur J Med Chem 2021 Aug 25;220:113453. Epub 2021 Apr 25.

School of Pharmacy, Xinxiang Medical University, Xinxiang, Henan, 453003, China. Electronic address:

LSD1 and HDAC are physical and functional related to each other in various human cancers and simultaneous pharmacological inhibition of LSD1 and HDAC exerts synergistic anti-cancer effects. In this work, a series of novel LSD1/HDAC bifunctional inhibitors with a styrylpyridine skeleton were designed and synthesized based on our previously reported LSD1 inhibitors. The representative compounds 5d and 5m showed potent activity against LSD1 and HDAC at both molecular and cellular level and displayed high selectivity against MAO-A/B. Moreover, compounds 5d and 5m demonstrated potent antiproliferative activities against MGC-803 and HCT-116 cancer cell lines. Notably, compound 5m showed superior in vitro anticancer potency against a panel of gastric cancer cell lines than ORY-1001 and SP-2509 with IC values ranging from 0.23 to 1.56 μM. Compounds 5d and 5m significantly modulated the expression of Bcl-2, Bax, Vimentin, ZO-1 and E-cadherin, induced apoptosis, reduced colony formation and suppressed migration in MGC-803 cancer cells. In addition, preliminary absorption, distribution, metabolism, excretion (ADME) studies revealed that compounds 5d and 5m showed acceptable metabolic stability in human liver microsomes with minimal inhibition of cytochrome P450s (CYPs). Those results indicated that compound 5m could be a promising lead compound for further development as a therapeutic agent in gastric cancers via LSD1 and HDAC dual inhibition.
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http://dx.doi.org/10.1016/j.ejmech.2021.113453DOI Listing
August 2021

Effects of preoperative serum vitamin D levels on early clinical function outcomes and the moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty.

Menopause 2021 May 3. Epub 2021 May 3.

Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.

Objective: To investigate the impact of vitamin D levels on early clinical function outcomes and the potential risk factors of moderate-to-severe pain prevalence in postmenopausal women after primary total knee arthroplasty (TKA).

Methods: From April 2017 to December 2019, 226 women were retrospectively recruited. The women were divided into two groups based on their preoperative serum 25-hydroxyvitamin D levels: (1) vitamin D-sufficient group (≥30 ng/mL); (2) vitamin D-deficient group (<30 ng/mL). The visual analog scale, Western Ontario and McMaster Arthritis Index score, and Knee Society Score were used to evaluate clinical outcomes. Risk factors for developing postoperative moderate-to-severe knee pain were studied using multivariate binary logistic regression analyses.

Results: There was no significant difference in preoperative clinical function assessment between the two groups. The difference in postoperative Western Ontario and McMaster Arthritis Index score between the two groups was statistically significant (15.3 ± 0.7 vs 15.6 ± 0.7: P = 0.02). However, the differences in postoperative visual analog scale and Knee Society Score scores between the two groups were not significant (P > 0.05). The incidence of postoperative moderate-to-severe pain was 16.4% (95% CI 11.8%-21.9%). Multivariate logistic regression analysis revealed that vitamin D deficiency, smoking, and high body mass index were potential risk factors for moderate-to-severe knee pain in postmenopausal women early after TKA (P < 0.05).

Conclusion: Preoperative vitamin D deficiency may adversely affect early functional outcomes in postmenopausal women after TKA. In addition, vitamin D deficiency, smoking, and high body mass index were independent risk factors for moderate-to-severe knee pain after surgery.
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http://dx.doi.org/10.1097/GME.0000000000001789DOI Listing
May 2021

KCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice.

Neurosci Bull 2021 May 26;37(5):597-610. Epub 2021 Apr 26.

Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, 221004, China.

Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that chronic constructive injury (CCI) in mice increased the firing activity and decreased the KCNQ channel-mediated M-currents in ventral tegmental area (VTA) DA neurons projecting to the nucleus accumbens (NAc). Chemogenetic inhibition of the VTA-to-NAc DA neurons alleviated CCI-induced thermal nociception. Opposite changes in the firing activity and M-currents were recorded in VTA DA neurons projecting to the medial prefrontal cortex (mPFC) but did not affect nociception. In addition, intra-VTA injection of retigabine, a KCNQ opener, while reversing the changes of the VTA-to-NAc DA neurons, alleviated CCI-induced nociception, and this was abolished by injecting exogenous BDNF into the NAc. Taken together, these findings highlight a vital role of KCNQ channel-mediated modulation of mesolimbic DA activity in regulating thermal nociception in the chronic pain state.
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http://dx.doi.org/10.1007/s12264-021-00668-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099961PMC
May 2021

Participation of the Anterior Cingulate Cortex in Sodium Salicylate-induced Tinnitus.

Otol Neurotol 2021 Apr 14. Epub 2021 Apr 14.

Department of Otolaryngology Head and Neck Surgery, Peking University Third Hospital Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing, China.

Hypothesis: The anterior cingulate cortex (ACC) participates in sodium salicylate (SS)-induced tinnitus through alteration of the disordered neural activity and modulates the neuronal changes in the auditory cortex (AC).

Background: Although the mechanism underlying tinnitus remains unclear, the crucial roles of the auditory center and limbic system in this process have been elucidated. Recent reports suggest that dysfunction of the ACC, an important component of the limbic system that regulates and controls the conduction of multiple sensations, is involved in tinnitus. Although altered functional connectivity between the ACC and the auditory system has been observed in humans with tinnitus, the underlying neuronal mechanism remains unexplored.

Methods: SS (350 mg/kg, 10%, i.p.) was used to yield tinnitus model in rats, followed by comparison of the alteration in the spontaneous firing rate (SFR), local field potential (LFP), and extracellular glutamic acid in the ACC. The responses of neurons in the AC to electrical stimulation from the ACC were also observed.

Results: We determined significant increases in the neuronal SFR and extracellular glutamate level in the ACC after SS injection (p < 0.05). These effects were accompanied by decreased alpha band activity and increased beta and gamma band activity (p < 0.05). In the majority of AC neurons, the SFR decreased in response to ACC stimulation (p < 0.05).

Conclusions: Our results demonstrated that disordered neural activity in the ACC contributes to SS-induced tinnitus and that ACC activation can modulate AC activity.
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http://dx.doi.org/10.1097/MAO.0000000000003183DOI Listing
April 2021

Temporal and spatial characteristics of turbulent transfer and diffusion coefficient of PM.

Sci Total Environ 2021 Aug 27;782:146804. Epub 2021 Mar 27.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, Department of Environmental Science, Peking University, Beijing 100081, PR China.

The temporal and spatial characteristics of turbulent transfer and diffusion coefficient of PM (K) were investigated by determining the deviation, turbulent flux and form of universal function of PM mass concentrations. Turbulence and sounding observations from December 8-25, 2019, of three sites, Tuonan, Baoding, and Renqiu stations in the North China Plain were selected. Mean PM mass fluxes during the intensive observational period of three stations were negative. The spatial distribution of PM mass flux of three stations showed no obvious tendency. Then, the fact that PM mass concentrations satisfied the Monin-Obukhov similarity were reconfirmed by examining the relationship between the normalized standard deviation of PM mass concentrations and stability factor ζ. Thus, the universal functions in the three stations were achieved. The time series and profiles of K in the three stations were also shown. There was a good inverse correlation between K and PM mass concentration which suggested that the influence of turbulent diffusion is remarkably important during observational time even the emission, deposition, secondary transformation can all affect the change of mass concentrations of PM in the ABL. Changes in K obviously presented diurnal characteristics. The comparisons of K and K and K suggested that the strength of turbulent PM mass flux exchange could be weaker or stronger than the strength of turbulent momentum and heat flux exchange at different stations. The magnitude relationship between K and K could not be completely determined, so there were limitations in using K to replace directly K in the existing numerical weather or climate models. Finally, the spatial distribution of K at the three stations presented almost symmetrical characteristics from east to west (Tuonan to Renqiu); that is, Baoding always had the lowest K, and Tuonan and Renqiu stations had higher Ks. The spatial distribution of K at the three stations corresponded well with that of PM mass concentrations, and Baoding always had the largest PM mass concentrations.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146804DOI Listing
August 2021