Yu Rao

Yu Rao

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PROTACs as Potential Therapeutic Agents for Cancer Drug Resistance.

Authors:
Xiuyun Sun Yu Rao

Biochemistry 2020 Jan 4;59(3):240-249. Epub 2019 Nov 4.

Ministry of Education (MOE) Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Tsinghua University , Beijing 100084 , P. R. China.

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http://dx.doi.org/10.1021/acs.biochem.9b00848DOI Listing
January 2020

Plasticity in designing PROTACs for selective and potent degradation of HDAC6.

Chem Commun (Camb) 2019 Dec;55(98):14848-14851

MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, P. R. China.

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http://dx.doi.org/10.1039/c9cc08509bDOI Listing
December 2019

Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.

ACS Med Chem Lett 2019 Dec 25;10(12):1667-1673. Epub 2019 Nov 25.

School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.

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http://dx.doi.org/10.1021/acsmedchemlett.9b00447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6912870PMC
December 2019

PROTACs: great opportunities for academia and industry.

Signal Transduct Target Ther 2019 24;4:64. Epub 2019 Dec 24.

1Ministry of Education (MOE) Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084 P. R. China.

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http://dx.doi.org/10.1038/s41392-019-0101-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927964PMC
December 2019

A single amino acid substitution in the FAD-binding domain causes the inactivation of isomerase.

Biosci Biotechnol Biochem 2019 Dec 31:1-8. Epub 2019 Dec 31.

State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.

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http://dx.doi.org/10.1080/09168451.2019.1709960DOI Listing
December 2019

Correction to: Developing potent PROTACs tools for selective degradation of HDAC6 protein.

Protein Cell 2019 Nov;10(11):854-855

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s13238-019-0613-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834731PMC
November 2019

Characterization of a probiotic starter culture with anti-Candida activity for Chinese pickle fermentation.

Food Funct 2019 Oct;10(10):6936-6944

School of Food Science and Bioengineering, Xihua University, Hongguang Street, Pidu District, Chengdu, 610039, China.

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http://dx.doi.org/10.1039/c9fo01191aDOI Listing
October 2019

Mucor indicus and Rhizopus oryzae co-culture to improve the flavor of Chinese turbid rice wine.

J Sci Food Agric 2019 Sep 1;99(12):5577-5585. Epub 2019 Jul 1.

Key Laboratory of Food Biotechnology of Sichuan, Xihua University, Chengdu, China.

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http://dx.doi.org/10.1002/jsfa.9831DOI Listing
September 2019

Developing potent PROTACs tools for selective degradation of HDAC6 protein.

Protein Cell 2019 08;10(8):606-609

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1007/s13238-018-0602-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626596PMC
August 2019

Degradation of Bruton's tyrosine kinase mutants by PROTACs for potential treatment of ibrutinib-resistant non-Hodgkin lymphomas.

Leukemia 2019 08 11;33(8):2105-2110. Epub 2019 Mar 11.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, P.R. China.

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http://dx.doi.org/10.1038/s41375-019-0440-xDOI Listing
August 2019

Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders.

J Med Chem 2019 Aug 2;62(16):7575-7582. Epub 2019 Aug 2.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Tsinghua University , Beijing 100084 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790125PMC
August 2019

Discovery of 4-Aminoquinoline-3-carboxamide Derivatives as Potent Reversible Bruton's Tyrosine Kinase Inhibitors for the Treatment of Rheumatoid Arthritis.

J Med Chem 2019 Jul 12;62(14):6561-6574. Epub 2019 Jul 12.

Ministry of Education (MOE) Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Tsinghua University , Beijing 100084 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00329DOI Listing
July 2019

Gram-scale total synthesis of teixobactin promoting binding mode study and discovery of more potent antibiotics.

Nat Commun 2019 07 22;10(1):3268. Epub 2019 Jul 22.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, 100084, Beijing, China.

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http://dx.doi.org/10.1038/s41467-019-11211-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646333PMC
July 2019

Aromaticity versus regioisomeric effect of β-substituents in porphyrinoids.

Phys Chem Chem Phys 2019 May;21(19):10152-10162

Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China.

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http://xlink.rsc.org/?DOI=C9CP01177C
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http://dx.doi.org/10.1039/c9cp01177cDOI Listing
May 2019

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.

J Med Chem 2019 Apr 12;62(8):4056-4073. Epub 2019 Apr 12.

College of Life Sciences , Hebei Normal University , Shijiazhuang , Hebei 050024 , P. R. China.

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http://dx.doi.org/10.1021/acs.jmedchem.9b00091DOI Listing
April 2019

A chemical approach for global protein knockdown from mice to non-human primates.

Cell Discov 2019 5;5:10. Epub 2019 Feb 5.

1Ministry of Education (MOE) Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084 China.

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http://dx.doi.org/10.1038/s41421-018-0079-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361926PMC
February 2019

Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule.

Chem Commun (Camb) 2019 Jan;55(3):369-372

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, P. R. China.

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http://dx.doi.org/10.1039/c8cc07813kDOI Listing
January 2019

Diagnostic accuracy of STAF, LADS, and iPAB scores for predicting paroxysmal atrial fibrillation in patients with acute cerebral infarction.

Clin Cardiol 2018 Dec 23;41(12):1507-1512. Epub 2018 Nov 23.

Department of Neurology, Huizhou Affiliated Hospital of Guangdong Medical University, Huizhou Municipal Central Hospital, Huizhou, China.

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http://dx.doi.org/10.1002/clc.23080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6489907PMC
December 2018

Design, synthesis and biological evaluation of novel zanamivir derivatives as potent neuraminidase inhibitors.

Bioorg Med Chem Lett 2018 12 26;28(23-24):3622-3629. Epub 2018 Oct 26.

School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, China.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183084
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http://dx.doi.org/10.1016/j.bmcl.2018.10.040DOI Listing
December 2018

Synthesis, Evaluation, and Structure-Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation.

J Med Chem 2018 10 24;61(19):8693-8706. Epub 2018 Sep 24.

Eye Center of the Second Affiliated Hospital, Institutes of Translational Medicine , Zhejiang University School of Medicine , Hangzhou 310058 , PR China.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.8b00705
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http://dx.doi.org/10.1021/acs.jmedchem.8b00705DOI Listing
October 2018

PROTAC-induced BTK degradation as a novel therapy for mutated BTK C481S induced ibrutinib-resistant B-cell malignancies.

Cell Res 2018 07 6;28(7):779-781. Epub 2018 Jun 6.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1038/s41422-018-0055-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028582PMC
July 2018

Loss of smooth muscle myosin heavy chain results in the bladder and stomach developing lesion during foetal development in mice.

J Genet 2018 Jun;97(2):469-475

State Key Laboratory of Agrobiotechnology, College of Biological Sciences China Agricultural University Beijing People's Republic of China.

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June 2018

Developing Equipotent Teixobactin Analogues against Drug-Resistant Bacteria and Discovering a Hydrophobic Interaction between Lipid II and Teixobactin.

J Med Chem 2018 04 13;61(8):3409-3421. Epub 2018 Apr 13.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology , Tsinghua University , Beijing 100084 , P. R. China.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01241
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http://dx.doi.org/10.1021/acs.jmedchem.7b01241DOI Listing
April 2018

Mixing O-Containing and N-Containing Directing Groups for C-H Activation: A Strategy for the Synthesis of Highly Functionalized 2,2'-Biaryls.

J Org Chem 2018 03 16;83(5):2582-2591. Epub 2018 Feb 16.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University , Beijing 100084, P.R. China.

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http://dx.doi.org/10.1021/acs.joc.7b02863DOI Listing
March 2018

Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.

J Med Chem 2017 10 21;60(19):7965-7983. Epub 2017 Sep 21.

School of Pharmacy, Second Military Medical University , 325 Guohe Road, Shanghai 200433, People's Republic of China.

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http://dx.doi.org/10.1021/acs.jmedchem.7b00467DOI Listing
October 2017

Synthesis and evaluation of osimertinib derivatives as potent EGFR inhibitors.

Bioorg Med Chem 2017 09 8;25(17):4553-4559. Epub 2017 Jul 8.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.06.004DOI Listing
September 2017

Enhancing the reactivity of nickel(ii) in hydrogen evolution reactions (HERs) by β-hydrogenation of porphyrinoid ligands.

Chem Sci 2017 Sep 19;8(9):5953-5961. Epub 2017 Jun 19.

Beijing National Laboratory for Molecular Sciences , State Key Laboratory of Rare Earth Materials Chemistry and Applications , College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , P. R. China . Email: ; Email: ; Email:

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http://dx.doi.org/10.1039/c7sc02073bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620542PMC
September 2017

An Improved FFR Design with a Ventilation Fan: CFD Simulation and Validation.

PLoS One 2016 25;11(7):e0159848. Epub 2016 Jul 25.

School of Power and Mechanical Engineering, Wuhan University, Wuhan, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0159848PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959710PMC
July 2017

Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria.

J Med Chem 2017 03 22;60(5):1994-2005. Epub 2017 Feb 22.

MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01733DOI Listing
March 2017

Regioselective Annulation of Aryl Sulfonamides with Allenes through Cobalt-Promoted C-H Functionalization.

Org Lett 2017 03 23;19(5):972-975. Epub 2017 Feb 23.

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acs.orglett.6b03510DOI Listing
March 2017

One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp)-H activations.

Chem Commun (Camb) 2017 Jan;53(9):1534-1537

MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.

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http://xlink.rsc.org/?DOI=C6CC06897A
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http://dx.doi.org/10.1039/c6cc06897aDOI Listing
January 2017

Auxiliary-assisted palladium-catalyzed halogenation of unactivated C(sp(3))-H bonds at room temperature.

Chem Commun (Camb) 2016 May 20;52(38):6423-6. Epub 2016 Apr 20.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://xlink.rsc.org/?DOI=C6CC00234J
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http://dx.doi.org/10.1039/c6cc00234jDOI Listing
May 2016

One-Step Synthesis of Diverse Pyridine-Containing Heterocycles with 3-Ethoxycyclobutanones at Room Temperature.

Org Lett 2016 05 26;18(9):2304-7. Epub 2016 Apr 26.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.

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http://pubs.acs.org/doi/10.1021/acs.orglett.6b01027
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http://dx.doi.org/10.1021/acs.orglett.6b01027DOI Listing
May 2016

A Preliminary Study of Diastereoselectivity in the Pd -Catalyzed C(sp )-H Alkoxylation of Cyclic Systems.

Chemistry 2016 Mar 16;22(10):3273-3277. Epub 2016 Feb 16.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1002/chem.201503967DOI Listing
March 2016

A diversity-oriented synthesis of bioactive benzanilides a regioselective C(sp)-H hydroxylation strategy.

Chem Sci 2016 Mar 3;7(3):2229-2238. Epub 2015 Dec 3.

MOE Key Laboratory of Protein Sciences , Department of Pharmacology and Pharmaceutical Sciences , School of Medicine and School of Life Sciences , Tsinghua University , Beijing 100084 , China . Email:

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http://dx.doi.org/10.1039/c5sc03905cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975941PMC
March 2016

Unactivated C(sp(3))-H hydroxylation through palladium catalysis with H2O as the oxygen source.

Chem Commun (Camb) 2015 Oct;51(80):14929-32

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1039/c5cc04952kDOI Listing
October 2015

Development of a Rhodium(II)-Catalyzed Chemoselective C(sp(3) )-H Oxygenation.

Chemistry 2015 Oct 27;21(42):14937-42. Epub 2015 Aug 27.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084 (P. R. China).

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http://dx.doi.org/10.1002/chem.201502140DOI Listing
October 2015

Weak Coordination Promoted Regioselective Oxidative Coupling Reaction for 2,2'-Difunctional Biaryl Synthesis in Hexafluoro-2-propanol.

Authors:
Chao Zhang Yu Rao

Org Lett 2015 Sep 31;17(18):4456-9. Epub 2015 Aug 31.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/acs.orglett.5b02115DOI Listing
September 2015

Pd(II) catalyzed ortho C-H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents.

Chem Commun (Camb) 2015 Jun;51(49):10014-7

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1039/c5cc02533hDOI Listing
June 2015

Palladium-catalyzed unactivated β-methylene C(sp(3))-H bond alkenylation of aliphatic amides and its application in a sequential C(sp(3))-H/C(sp(2))-H bond alkenylation.

Org Biomol Chem 2015 Jan;13(3):697-701

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1039/c4ob02389gDOI Listing
January 2015

The synthesis of diarylsulfones with simple arenes and K2S2O8 through double C-S bond formation.

Chem Commun (Camb) 2014 Dec;50(95):15037-40

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://xlink.rsc.org/?DOI=C4CC05964F
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http://dx.doi.org/10.1039/c4cc05964fDOI Listing
December 2014

Investigation of effect of 17α-ethinylestradiol on vigilin expression using an isolated recombinant antibody.

Aquat Toxicol 2014 Nov 29;156:1-9. Epub 2014 Jul 29.

State Key Laboratory of Fresh water Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Southern East Lake Road, Wuhan 430072, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.aquatox.2014.07.016DOI Listing
November 2014

Developing Pd(II) catalyzed double sp3 C-H alkoxylation for synthesis of symmetric and unsymmetric acetals.

Authors:
Yu Zong Yu Rao

Org Lett 2014 Oct 29;16(20):5278-81. Epub 2014 Sep 29.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/ol502377xDOI Listing
October 2014

Distribution of vitellogenin in zebrafish (Danio rerio) tissues for biomarker analysis.

Aquat Toxicol 2014 Apr 2;149:1-7. Epub 2014 Feb 2.

State Key Laboratory of Fresh Water Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, 7 Southern East Lake Road, Wuhan 430072, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.aquatox.2014.01.022DOI Listing
April 2014

Synthesis of indazoles and azaindazoles by intramolecular aerobic oxidative C-N coupling under transition-metal-free conditions.

Chemistry 2014 Apr 3;20(14):3932-8. Epub 2014 Mar 3.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084 (China).

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http://doi.wiley.com/10.1002/chem.201304923
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http://dx.doi.org/10.1002/chem.201304923DOI Listing
April 2014

Room-temperature Pd-catalyzed C-H chlorination by weak coordination: one-pot synthesis of 2-chlorophenols with excellent regioselectivity.

Chem Commun (Camb) 2014 Feb;50(10):1262-4

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://xlink.rsc.org/?DOI=C3CC47431C
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http://dx.doi.org/10.1039/c3cc47431cDOI Listing
February 2014

Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.

Proc Natl Acad Sci U S A 2014 Jan 27;111(2):652-7. Epub 2013 Dec 27.

Laboratory of Non-Coding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

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http://dx.doi.org/10.1073/pnas.1321032111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896195PMC
January 2014

An efficient palladium-catalyzed C-H alkoxylation of unactivated methylene and methyl groups with cyclic hypervalent iodine (i(3+) ) oxidants.

Angew Chem Int Ed Engl 2013 Dec 8;52(51):13606-10. Epub 2013 Nov 8.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084 (China).

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http://dx.doi.org/10.1002/anie.201307090DOI Listing
December 2013

Synthesis of 2-aminophenols and heterocycles by Ru-catalyzed C-H mono- and dihydroxylation.

Org Lett 2013 May 26;15(10):2334-7. Epub 2013 Apr 26.

MOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University , Beijing 100084, China.

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http://dx.doi.org/10.1021/ol400437aDOI Listing
May 2013

Broadening the catalyst and reaction scope of regio- and chemoselective C-H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(II) and Ru(II) catalysis.

Org Biomol Chem 2013 Apr;11(14):2318-22

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://xlink.rsc.org/?DOI=c3ob27457h
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http://dx.doi.org/10.1039/c3ob27457hDOI Listing
April 2013

Regio- and chemoselective C-H chlorination/bromination of electron-deficient arenes by weak coordination and study of relative directing-group abilities.

Angew Chem Int Ed Engl 2013 Apr 19;52(16):4440-4. Epub 2013 Mar 19.

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing, 100084, China.

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http://dx.doi.org/10.1002/anie.201300176DOI Listing
April 2013

Pd-catalyzed C-H oxygenation with TFA/TFAA: expedient access to oxygen-containing heterocycles and late-stage drug modification.

Angew Chem Int Ed Engl 2012 Dec 19;51(52):13070-4. Epub 2012 Nov 19.

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1002/anie.201207458DOI Listing
December 2012

Synthesis of tri- and tetrasubstituted pyrazoles via Ru(II) catalysis: intramolecular aerobic oxidative C-N coupling.

Org Lett 2012 Oct 18;14(19):5030-3. Epub 2012 Sep 18.

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1021/ol3022353DOI Listing
October 2012

Crystal structure of a bacterial homologue of glucose transporters GLUT1-4.

Nature 2012 Oct;490(7420):361-6

State Key Laboratory of Bio-membrane and Membrane Biotechnology, Center for Structural Biology, Tsinghua University, Beijing 100084, China.

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http://www.nature.com/articles/nature11524
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http://dx.doi.org/10.1038/nature11524DOI Listing
October 2012

Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group.

Org Lett 2012 Jun 14;14(11):2874-7. Epub 2012 May 14.

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1021/ol301104nDOI Listing
June 2012

A new practical approach towards the synthesis of unsymmetric and symmetric 1,10-phenanthroline derivatives at room temperature.

Chem Commun (Camb) 2012 Mar 6;48(23):2906-8. Epub 2012 Feb 6.

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing, 100084, China.

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http://xlink.rsc.org/?DOI=c2cc17208a
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http://dx.doi.org/10.1039/c2cc17208aDOI Listing
March 2012

A facile synthesis of substituted 2-alkylquinolines through [3+3] annulation between 3-ethoxycyclobutanones and aromatic amines at room temperature.

Org Lett 2011 Nov 3;13(21):5770-3. Epub 2011 Oct 3.

Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://pubs.acs.org/doi/abs/10.1021/ol202334s
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http://dx.doi.org/10.1021/ol202334sDOI Listing
November 2011

[Strategy for soluble expression of phage-displayed scFv antibody specific for zebrafish vitellogenin].

Sheng Wu Gong Cheng Xue Bao 2011 Nov;27(11):1637-44

State Key Laboratory of Freshwater Ecology and Biotechnology, Institution of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China.

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November 2011

A general and efficient approach to 2H-indazoles and 1H-pyrazoles through copper-catalyzed intramolecular N-N bond formation under mild conditions.

Chem Commun (Camb) 2011 Sep 9;47(36):10133-5. Epub 2011 Aug 9.

Department of Pharmacology and Pharmaceutical Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1039/c1cc13908hDOI Listing
September 2011

A new synthesis of pyrazoles through a Lewis acid catalyzed union of 3-ethoxycyclobutanones with monosubstituted hydrazines.

Org Lett 2011 Apr 7;13(7):1746-9. Epub 2011 Mar 7.

Department of Pharmacology and Pharmaceutical Sciences, School of Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China.

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http://dx.doi.org/10.1021/ol2002682DOI Listing
April 2011

Novel recombinant monoclonal antibodies for vitellogenin assays in cyprinid fish species.

Dis Aquat Organ 2010 Dec;93(1):83-91

Institute of Hydrobiology, Chinese Academy of Sciences, 7 Southern East Lake Road, Wuchang, Wuhan, Hubei 430072, PR China.

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http://www.int-res.com/abstracts/dao/v93/n1/p83-91/
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http://dx.doi.org/10.3354/dao02268DOI Listing
December 2010

A Simple Method for the Conversion of Carboxylic Acids into Thioacids with Lawesson's Reagent.

Tetrahedron Lett 2009 Dec;50(48):6684-6686

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.tetlet.2009.09.080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762222PMC
December 2009

Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds.

J Am Chem Soc 2009 Sep;131(36):12924-6

Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.

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http://dx.doi.org/10.1021/ja906005jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756580PMC
September 2009

Generation of recombinant monoclonal antibodies to study structure-function of envelope protein VP28 of white spot syndrome virus from shrimp.

Biochem Biophys Res Commun 2008 Aug 4;372(4):902-6. Epub 2008 Jun 4.

Institute of Hydrobiology, Chinese Academy of Sciences, 7 Southern East Lake Road, Wuchang, Wuhan, Hubei 430072, PR China.

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X080108
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http://dx.doi.org/10.1016/j.bbrc.2008.05.152DOI Listing
August 2008

Synthesis and immunological properties of a tetrasaccharide portion of the B side chain of rhamnogalacturonan II (RG-II).

Chembiochem 2008 Feb;9(3):381-8

Complex Carbohydrate Research Center, The University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.

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http://doi.wiley.com/10.1002/cbic.200700501
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http://dx.doi.org/10.1002/cbic.200700501DOI Listing
February 2008

A highly convergent chemical synthesis of conformational epitopes of rhamnogalacturonan II.

Angew Chem Int Ed Engl 2007 ;46(32):6148-51

Complex Carbohydrate Research Center, The University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.

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http://dx.doi.org/10.1002/anie.200701750DOI Listing
October 2007

Practical approach for the stereoselective introduction of beta-arabinofuranosides.

J Am Chem Soc 2006 Sep;128(36):11948-57

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, USA.

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http://dx.doi.org/10.1021/ja0629817DOI Listing
September 2006

Smokers at higher risk for undetected antibody for oncogenic human papillomavirus type 16 infection.

Cancer Epidemiol Biomarkers Prev 2006 May;15(5):915-20

School of Nursing, University of California at Los Angeles, Los Angeles, CA 90095-6919, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0963DOI Listing
May 2006

Trisaccharide mimetics of the aminoglycoside antibiotic neomycin.

Org Biomol Chem 2006 Apr 22;4(7):1328-37. Epub 2006 Feb 22.

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA.

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http://dx.doi.org/10.1039/b517725aDOI Listing
April 2006