Publications by authors named "Yu Jin Oh"

20 Publications

  • Page 1 of 1

Bakkenolides and Caffeoylquinic Acids from the Aerial Portion of and Their Bacterial Neuraminidase Inhibition Ability.

Biomolecules 2020 06 10;10(6). Epub 2020 Jun 10.

Plant Resource Industry Division, Forest Plant Industry Department, Baekdudaegan National Arboretum, Bonghwa-gun 26209, Korea.

have been used since a long time in folk medicine to treat diseases including plague, pestilential fever, allergy, and inflammation in East Asia and European countries. Bioactive compounds that may prevent and treat infectious diseases are identified based on their ability to inhibit bacterial neuraminidase (NA). We aimed to isolate and identify bioactive compounds from leaves and stems of (PJA) and elucidate their mechanisms of NA inhibition. Key bioactive compounds of PJA responsible for NA inhibition were isolated using column chromatography, their chemical structures revealed using H NMR, C NMR, DEPT, and HMBC, and identified to be bakkenolide B (), bakkenolide D (), 1,5-di--caffeoylquinic acid (), and 5--caffeoylquinic acid (). Of these, exhibited the most potent NA inhibitory activity (IC = 2.3 ± 0.4 μM). Enzyme kinetic studies revealed that and were competitive inhibitors, whereas exhibited non-competitive inhibition. Furthermore, a molecular docking simulation revealed the binding affinity of these compounds to NA and their mechanism of inhibition. Negative-binding energies indicated high proximity of these compounds to the active site and allosteric sites of NA. Therefore, PJA has the potential to be further developed as an antibacterial agent for use against diseases associated with NA.
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http://dx.doi.org/10.3390/biom10060888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7357027PMC
June 2020

Indoor levels of volatile organic compounds and formaldehyde from emission sources at elderly care centers in Korea.

PLoS One 2018 7;13(6):e0197495. Epub 2018 Jun 7.

Department of Environmental Health Science, Soonchunhyang University, Asan, Republic of Korea.

The objective of this study is to characterize indoor and outdoor levels of volatile organic compounds (VOCs) and formaldehyde (HCHO) and identify indoor emission sources in thirty elderly care centers (ECCs) located in the Seoul metropolitan city and Gyeonggi province in Korea. Air monitoring samples from indoor and outdoor environments were collected from January to December in 2007. Statistical analyses of indoor and outdoor VOCs and HCHO levels in three rooms (a bedroom, living, and dining rooms) of each ECC were performed, and these were compared to identify environmental factors associated with an increase of indoor pollution levels. Total volatile organic compounds (TVOC) levels were significantly (p<0.05) different between indoor (230.7±1.7 μg/m3) and outdoor (137.8±1.9 μg/m3) environments, with an I/O ratio of 1.67. The indoor HCHO level (20.1±1.6 μg/m3) was significantly (p<0.05) higher than the outdoor level (8.1±1.9 μg/m3), with an I/O ratio of 2.48. Indoor VOCs and HCHO levels in the bedrooms were significantly (p<0.05) higher than those in the living and dining rooms. Furthermore, indoor levels of VOCs and HCHO at ECCs were significantly (p<0.05) different depending on environmental factors such as the use of carpet, paint, and wooden furniture. In multiple regression analysis, indoor VOCs and HCHO levels at ECCs were significantly (p<0.05) correlated with two micro-environmental factors: the use of carpet and paint. This study confirmed that indoor VOCs and HCHO levels were significantly higher than those in outdoor environments. These air pollutants were mainly emitted from indoor sources, such as carpet, paint, and construction materials at the ECCs in Korea.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197495PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5991643PMC
November 2018

Protection of Radiation-Induced DNA Damage by Functional Cosmeceutical Poly-Gamma-Glutamate.

J Microbiol Biotechnol 2018 Apr;28(4):527-533

Department of Bio and Fermentation Convergence Technology, BK21 PLUS project, Kookmin University, Seoul 02707, Republic of Korea.

This study compared the radioprotective effects of high-molecular-weight poly-gamma-glutamate (γ-PGA, average molecular mass 3,000 kDa) and a reduced form of glutathione (GSH, a known radioprotector) on calf thymus DNA damage. The radiation-induced DNA damage was measured on the basis of the decreased fluorescence intensity after binding the DNA with ethidium bromide. All the experiments used ⁶⁰Co gamma radiation at 1,252 Gy, representing 50% DNA damage. When increasing the concentration of γ-PGA from 0.33 to 1.65 μM, the DNA protection from radiation-induced damage also increased, with a maximum of 87% protection. Meanwhile, the maximal DNA protection when increasing the concentration of GSH was only 70%. Therefore, γ-PGA exhibited significant radioprotective effects against gamma irradiation.
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http://dx.doi.org/10.4014/jmb.1712.12016DOI Listing
April 2018

Primary Cutaneous Apocrine Carcinoma.

Ann Dermatol 2016 Oct 30;28(5):669-670. Epub 2016 Sep 30.

Department of Dermatology, Kyung Hee University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5021/ad.2016.28.5.669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064209PMC
October 2016

Serum leptin and adiponectin levels in Korean patients with psoriasis.

J Korean Med Sci 2014 May 25;29(5):729-34. Epub 2014 Apr 25.

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

Psoriasis is a disorder caused by genetic and immunological factors. Leptin, a peptide hormone secreted predominantly from adipose tissue, regulates energy intake and expenditure, as well as the T-helper response. There have been conflicting reports regarding serum levels of leptin and adiponectin in patients with psoriasis. In the present study, we measured serum levels of leptin and adiponectin in Korean patients with psoriasis. Twenty-four patients with psoriasis and fifteen control subjects were included in the study. Serum leptin and adiponectin levels were determined by an immunometric sandwich enzyme-linked immunosorbent assay (ELISA). The mean serum leptin concentration in patients with psoriasis was higher than in controls, and the difference was statistically significant. In contrast, serum adiponectin levels in patients with psoriasis were significantly decreased compared with healthy controls. Leptin levels in vitamin D-deficient patients were statistically significantly higher than in vitamin D-sufficient patients. Serum adiponectin concentrations showed a negative correlation with body mass index (BMI) and psoriasis area and severity index (PASI) in patients with psoriasis. In conclusion, the present study demonstrated that leptin and adiponectin may play a role in the immunopathogenesis of psoriasis and may be useful biomarkers indicating severity of psoriasis in Korean patients.
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http://dx.doi.org/10.3346/jkms.2014.29.5.729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4024941PMC
May 2014

Effect of hydroxypropyl methyl cellulose phthalate coating on digestive stability and intestinal transport of green tea catechins.

Integr Med Res 2014 Mar 9;3(1):34-37. Epub 2013 Dec 9.

Department of Food Science and Technology and Carbohydrate Bioproduct Research Center, Sejong University, Seoul, Korea.

Background: The purpose of this study was to investigate the effect of hydroxypropyl methyl cellulose phthalate (HPMCP) coating on the digestive stability and intestinal transport of green tea catechins (GTCs).

Methods: Two types of HPMCP coating were prepared: one type with size smaller than 500 μm (S-HPMCP) and the other with size larger than 500 μm (L-HPMCP). An gastrointestinal model system coupled with Caco-2 cells was used for estimating the bioavailability of GTCs. Ultraperformance liquid chromatography with a photodiode array detector was performed to analyze GTCs.

Results: The digestive stability of GTCs was enhanced up to 33.73% and 35.28% for S-HPMCP and L-HPMCP, respectively. Intestinal transport of the GTCs was increased to 22.98% and 23.23% for S-HPMCP and L-HPMCP, respectively. Overall, the bioavailability of GTCs increased by 4.08 and 11.71 times for S-HPMCP and L-HPMCP, respectively.

Conclusion: The results of this study confirm that coating with HPMCP could be a way to improve the digestive stability and intestinal transport of GTCs.
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http://dx.doi.org/10.1016/j.imr.2013.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481709PMC
March 2014

Green tea formulations with vitamin C and xylitol on enhanced intestinal transport of green tea catechins.

J Food Sci 2013 May 1;78(5):C685-90. Epub 2013 Apr 1.

Dept. of Food Science & Technology and Carbohydrate Bioproduct Research Center, Sejong Univ., 98 Gunja-dong, Gwangjin-gu, Seoul, 143-747, Republic of Korea.

The effect of green tea formulated with vitamin C and xylitol on intestinal cell transport of gallated and nongallated catechin was studied. The transport of catechins from both apical to basolateral and basolateral to apical directions was measured. The effect of vitamin C (4, 10, 20 ppm), xylitol (11, 27.5, 55 ppm), and combinations of both on the intestinal transport rate of catechins was examined. The efflux value (Pb→a/Pa→b) of (-)-epigallocatechin (EGC), (-)-epigallocatechin gallate (EGCG), (-)-epicatechin (EC), and (-)-epicatechin gallate (ECG) was 0.26, 0.22, 1.22, and 0.17, respectively, indicating that EC appeared to be less absorbed compared with other catechins. The addition of xylitol (11, 27.5, 55 ppm) and vitamin C (4, 10, 20 ppm) and in combination enhanced transport rate of nongallated catechins such as EC and EGC. For EC, vitamin C was revealed to be the most effective on intestinal transport, implying the inhibition of the efflux transport mechanism of EC. Intestinal transport of gallated catechins significantly increased from catechins formulated with vitamin C and xylitol in a dose-dependent manner compared to the catechin-only formulation. Results provide a potential strategy to enhance the delivery and bioavailability of catechins in humans by modulating green tea formulation with vitamin C and xylitol.
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http://dx.doi.org/10.1111/1750-3841.12112DOI Listing
May 2013

A intense-focused ultrasound tightening for the treatment of infraorbital laxity.

J Cosmet Laser Ther 2012 Dec;14(6):290-5

Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.

Background: Infraorbital laxity is a common problem that increases with age. Blepharoplasty with lipectomy is a very commonly performed surgical procedure to treat this problem; however, it is invasive and is associated with the potential for re-emergence. Therefore, young patients may prefer a non-surgical procedure rather than to a surgical procedure. Intense-focused ultrasound (IFUS) has emerged as an effective, non-surgical, tissue-tightening procedure.

Objective: This study assessed the safety and efficacy of IFUS (Ulthera system, Ulthera Inc, Mesa, AZ, U.S.A.) for facial tightening in Asian patients with infraorbital laxity.

Methods: We studied 15 patients who were treated with an IFUS device applied to both lower eyelids. The primary outcome measure was an objective improvement in a paired comparison of pre-treatment and post treatment (6 months) photographs. A secondary outcome measure was patient satisfaction as measured by a questionnaire.

Results: The mean patient age was 50 years (range, 27-69). All patients received one to two treatments with intense-focused ultrasound. All patients in the study experienced both subjective and objective improvement.

Conclusion: IFUS can be used as a non-invasive, skin-tightening procedure for infraorbital laxity. No serious, permanent, or delayed side effects were noted up to 6 months post treatment. Thus, this procedure can be effective and safe in the treatment of decreased laxity of the lower eyelids.
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http://dx.doi.org/10.3109/14764172.2012.738912DOI Listing
December 2012

Subcutaneous Sweet syndrome with nuclear segmentation anomalies: a diagnostic marker of myelodysplasia.

Int J Dermatol 2012 Aug;51(8):976-8

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

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http://dx.doi.org/10.1111/j.1365-4632.2011.05103.xDOI Listing
August 2012

Narrow-band ultraviolet B treatment for diphenylcyclopropenone-induced vitiliginous lesions.

Acta Derm Venereol 2012 Jan;92(1):102-3

Department of Dermatology, College of Medicine, Kyung Hee University, Dongdaemun-gu, Seoul, Korea.

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http://dx.doi.org/10.2340/00015555-1176DOI Listing
January 2012

Acantholytic Anaplastic Extramammary Paget's Disease: A Case Report and Review of the Literature.

Ann Dermatol 2011 Oct 31;23(Suppl 2):S226-30. Epub 2011 Oct 31.

Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.

Extramammary Paget's disease (EMPD) is an uncommon intraepithelial neoplasm that most commonly arises on the vulva and perianal region. Very few cases of EMPD revealing a histological Bowenoid appearance have been reported. This study describes scrotal EMPD presenting with histological features of Bowen's disease in a 79-year-old man. He presented with a 5-year history of a pruritic erythematous plaque and a verrucous papule on the scrotum. The verrucous papule histopathologically showed Bowenoid features, and the erythematous plaque demonstrated acantholytic EMPD. Immunohistochemical findings revealed strong expression for carcinoembryonic antigen, Cam 5.2, epithelial membrane antigen, cytokeratin (CK) 7, and pancytokeratin (AE1/AE3) in both areas, but negative CK20 staining, supporting the overall diagnosis of primary acantholytic anaplastic EMPD. This is the first reported case of acantholytic anaplastic EMPD in the Korean literature.
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http://dx.doi.org/10.5021/ad.2011.23.S2.S226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229072PMC
October 2011

CK20 Positive Large-cell Neuroendocrine Carcinoma Presenting with Skin Metastases.

Ann Dermatol 2011 Sep 30;23 Suppl 1:S20-4. Epub 2011 Sep 30.

Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.

We present a case of cytokeratin (CK) 20-positive large cell neuroendocrine carcinoma (LCNEC) presenting with multiple skin metastases as the primary manifestation. The patient was a 55-year-old man who presented with a one- month history of subcutaneous skin colored nodules of various sizes on his trunk. Pathologic examination of the skin revealed a nested and solid proliferation of large undifferentiated cells with vesicular nuclei and prominent nucleoli. Tumor cells were found to be immunohistochemically positive for CK 20, chromogranin A, synaptophysin, and CD56. Based on these features, the tumor was diagnosed as a large cell neuroendocrine carcinoma with multiple skin metastases. Computed tomographic (CT) imaging found metastatic foci in the liver, pleura, bone, and lymph nodes. We were unable to identify the primary site of origin. To the best of our knowledge, this is the first case of a large cell neuroendocrine carcinoma with a primary manifestation of multiple skin metastases.
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http://dx.doi.org/10.5021/ad.2011.23.S1.S20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3199414PMC
September 2011

A split-face study using botulinum toxin type B to decrease facial erythema index.

J Cosmet Laser Ther 2011 Oct;13(5):243-8

Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea.

Introduction: A reddish tone in facial skin is a common concern of patients who suffer from facial flushing. No studies have been conducted to date for evaluation of the effect of botulinum toxin type B (BTX-B) on facial flushing.

Materials And Method: We evaluated the efficacy of BTX-B for improvement of facial flushing. Fifteen Korean subjects who complained of facial flushing were enrolled in this study. Patients were randomized to receive BTX-B injections on one side of the face, with the other side receiving saline control injections. Changes in skin tone were evaluated using an overall self-assessment and an objective mexameter.

Result: After treatment, this mexameter demonstrated significant improvement of erythema at 8 weeks after injections on both sides. However, according to the change in erythema index measures between the two groups, the BTX-B injection side did not show a significant decrease in objective erythema, compared with the control side. Subjective satisfaction did not differ between the treated side and the control side.

Conclusion: Although findings from this study suggest that BTX-B was ineffective in treatment of facial flushing, it is significant that, to the best of our knowledge, this is the first report on an investigator-initiated, randomized, split-face trial for evaluation of efficacy of BTX-B treatment for facial flushing.
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http://dx.doi.org/10.3109/14764172.2011.613479DOI Listing
October 2011

Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model.

J Control Release 2011 Feb 9;150(1):56-62. Epub 2010 Nov 9.

Department of Bioengineering, Hanyang University, Seoul 133-791, Republic of Korea.

Inhaling corticosteroids, such as budesonide (BD), is the most common treatment for asthma. However, frequent steroid administration is associated with many side effects. We hypothesized that porous microparticles containing BD could provide an effective treatment method for asthma, as the sustained delivery of corticosteroid and a reduced number of doses could be achieved using porous polymeric microparticles. Porous microparticles were prepared from poly(lactic-co-glycolic acid) (PLGA) by a water-in-oil-in-water double emulsion method with ammonium bicarbonate as the porogen. Varying the porogen concentration controlled the morphology, particle size, and pore size of the PLGA microparticles, with particle size and pore size increasing as the porogen concentration increased. The BD loading efficiency in the porous PLGA microparticles was about 60%, and BD was released from the porous microparticles in a sustained manner for 24h in vitro. Lung uptake efficiency of the porous PLGA microparticles in mice was significantly higher than that of non-porous PLGA microparticles. Budesonide-loaded porous PLGA microparticles were delivered to asthmatic mice, and the numbers of inflammatory cells in bronchoalveolar lavage (BAL) fluid and tissue sections were significantly reduced when the drug was administrated every 3days. We also found significantly reduced bronchial hyperresponsiveness of asthmatic mice after treatment with budesonide-loaded porous PLGA microparticles. This approach to controlling the porous structure of polymeric microparticles, as well as the release behavior of drugs from the microparticles, could have useful applications in the pulmonary delivery of many therapeutic drugs.
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http://dx.doi.org/10.1016/j.jconrel.2010.11.001DOI Listing
February 2011

Facile control of porous structures of polymer microspheres using an osmotic agent for pulmonary delivery.

J Control Release 2010 Aug 26;146(1):61-7. Epub 2010 May 26.

Department of Bioengineering, Hanyang University, Seoul 133-791, Republic of Korea.

It has been challenging to prepare polymeric microspheres with controlled porous structures for many biomedical applications, particularly for pulmonary drug delivery. Here, we report the use of bovine serum albumin (BSA) as an osmotic agent in order to control the porous structure of poly(D,L-lactide-co-glycolide) (PLGA) microspheres prepared by a double emulsion method. BSA was useful to induce osmosis between internal and external water phases during the double emulsion process, resulting in the fabrication of microspheres with controllable, uniform porous structures. The pore size of PLGA microspheres was controlled independently from the particle size by this approach. The use of BSA as an osmotic agent reduced the initial burst of model proteins (e.g., insulin and VEGF) entrapped in the porous microspheres, and the sustained release of VEGF was achieved for two weeks in vitro. This approach to controlling porous structures of polymer microspheres could be useful to develop novel pulmonary drug delivery systems.
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http://dx.doi.org/10.1016/j.jconrel.2010.05.026DOI Listing
August 2010

Comparison of student's satisfaction on school food service environment by the eating place and gender.

Nutr Res Pract 2009 31;3(4):295-9. Epub 2009 Dec 31.

Department of Food and Nutrition, Kyungwon University, Bokjeong-dong, Sujeong-gu, Seongnam, Gyeonggi 461-701, Korea.

The purpose of this study was to compare student's satisfaction with school food service environment to improve the quality of middle school meal service. A survey was conducted of 680 students (boys 246, girls 433) from 6 middle schools providing school meals from October to November 2007. The questionnaires were directly distributed to the subjects for comparison of satisfaction of school meals depending on the eating place. As for the quantity of food, classroom group (3.40) expressed significantly higher satisfaction than cafeteria group (3.16, P < 0.01), but as for the satisfaction on hygiene, classroom group (2.76) showed significantly lower satisfaction than cafeteria group (3.03, P < 0.01). About the satisfaction of school meal environment, classroom group showed more satisfaction on distribution time, eating place, eating atmosphere (P < 0.001). The classroom group showed higher satisfaction than cafeteria group in cases of quantity, diversity of types of soup, dessert, and the cost of school meal. To improve eating place and hygiene of school meal, sufficient cafeteria space and pleasant environment is needed to be established.
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http://dx.doi.org/10.4162/nrp.2009.3.4.295DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809236PMC
July 2011

Spontaneously infarcted fibroadenoma mimicking breast cancer.

J Ultrasound Med 2009 Oct;28(10):1421-3

Department of Radiology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

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http://dx.doi.org/10.7863/jum.2009.28.10.1421DOI Listing
October 2009

Mothers' perceptions of children's food behaviors: use of focus group interview study.

Nutr Res Pract 2008 31;2(4):259-68. Epub 2008 Dec 31.

Department of Food and Nutrition, Kyungwon University, Bokjeong-dong, Sujeong-gu, Seongnam-si, Kyungki 461-701, Korea.

Children's food behaviors have been expressed in a various ways because of recent changes in their family environment. Thus, this study was performed to investigate in-depth qualitative research on the mother's perception on children's food behaviors by focused group interview. This study was designed in four steps of planning, collection of participants, process, and analysis. Participants for the focus group interview were recruited and sampled from households with elementary school students in the Seoul and Gyeonggido areas. Groups were divided by total income and education expense levels. 1) High income household: It is better to improve currently existing web sites for nutrition education. 2) Mid income household: Easy, practical, and inexpensive off-line cooking class/nutrition education classes for mothers are needed. Nutrition programs for children should be developed through mass media and be promoted in the broadcasting circle. 3) Low income household: Motivation is required for mothers' education and the serious nutritional problems of children should be informed through mass media and home correspondence from school. And interesting educational materials should be developed for children to read whenever they want.
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http://dx.doi.org/10.4162/nrp.2008.2.4.259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2788199PMC
July 2011

"Nutrition exploration" with food characters: interactive multimedia nutrition software for preschoolers.

J Nutr Educ Behav 2007 May-Jun;39(3):173-4

Department of Food and Nutrition, Kyungwon University, Seongnam, South Korea.

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http://dx.doi.org/10.1016/j.jneb.2006.10.004DOI Listing
July 2007