Publications by authors named "Yu Gao"

1,064 Publications

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The effects of radiotherapy after thoracic and laparoscopic surgery on patients with esophageal cancer and on their prognoses.

Am J Transl Res 2021 15;13(6):6446-6456. Epub 2021 Jun 15.

Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University Hefei, Anhui Province, China.

Objective: This paper aimed to explore the effects of radiotherapy after thoracic and laparoscopic surgery (TLS) in patients with esophageal cancer and on their prognoses.

Methods: Altogether 118 patients with esophageal cancer diagnosed in our hospital were recruited as the study cohort and randomly divided into a postoperative radiotherapy group (59 cases) and a postoperative chemotherapy group (59 cases). All the patients were treated with TLS. In addition to the TLS, the patients in the postoperative radiotherapy group underwent radiotherapy, and the patients in the postoperative chemotherapy group were administered cisplatin and 5-fluorouracil (PF) chemotherapy. Before the treatment and at 6 months after the treatment, the serum carbohydrate antigen 199 (CA199), carbohydrate antigen 153 (CA153), and carcinoembryonic antigen (CEA) levels were measured using immunity transmission turbidity (ITT). The expression levels of Bax and Bcl-2 in the peripheral blood mononuclear cells (PBMCs) were measured using Western blot (WB). The CD4, CD8 and CD3 levels in the peripheral venous blood were measured using a flow cytometer. The two groups were compared in terms of their effective treatment rates, their incidences of complications, and their postoperative survival rates.

Results: After the treatment, the serum CEA, CA153, and CA199 levels in the postoperative radiotherapy group were significantly lower than they were in the postoperative chemotherapy group (P<0.05). After the treatment, the expression level of Bcl-2 was significantly lower in the postoperative radiotherapy group, but the Bax expression level was significantly higher in the postoperative radiotherapy group (P<0.05). After the treatment, there were no statistically significant differences in the CD4, CD3 or CD8 levels between the two groups (P>0.05). After the treatment, the overall response rate (ORR) and the total incidence of adverse reactions were significantly higher in the postoperative radiotherapy group (P<0.05). After the treatment, the 1-year, 3-year, and 5-year survival rates were significantly elevated in the postoperative radiotherapy group (P<0.05).

Conclusion: Compared with the esophageal cancer patients treated with chemotherapy after TLS, the serum CA153, CA199, and CEA levels were significantly improved in the patients treated with radiotherapy. The Bcl-2 and Bax levels in the PBMCs tended close to normal. Therefore, undergoing radiotherapy after TLS is markedly effective in prolonging patients' survival times and improving their prognoses.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8290759PMC
June 2021

Recreational Screen Time and Anxiety among College Athletes: Findings from Shanghai.

Int J Environ Res Public Health 2021 Jul 13;18(14). Epub 2021 Jul 13.

Department of Public Health Sciences, Clemson University, Clemson, SC 29634, USA.

To better understand the behavioral factors contributing to the mental health status among student athletes, we examined the link between recreational screen time and college student athlete's anxieties. This cross-sectional study was conducted among 278 college student athletes from Shanghai, China, aged between 17 and 25 years old ( = 19.4, = 1.5). Multivariate regression analyses, controlled for age, gender, rural vs. urban residency, and individual vs. team sports factors, were performed to analyze the association between their average daily recreational screen time in a week and their dispositional anxiety, pre-competition anxiety, and anxiety during competition, which were measured by the Chinese version of validated psychometric scales among athlete population. Significant results were found in both dispositional anxiety and situational anxiety in relation to recreational screen time among college athletes. Conclusions: Our findings indicate that excessive recreational screen time is a risk indicator of college student athletes' dispositional anxiety, pre-competition anxiety, and anxiety during competition.
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http://dx.doi.org/10.3390/ijerph18147470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8306689PMC
July 2021

Evaluation of T2-Weighted MRI for Visualization and Sparing of Urethra with MR-Guided Radiation Therapy (MRgRT) On-Board MRI.

Cancers (Basel) 2021 Jul 16;13(14). Epub 2021 Jul 16.

Physics and Biology in Medicine IDP, University of California, 650 Charles E Young Drive S, Los Angeles, CA 90095, USA.

Purpose: To evaluate urethral contours from two optimized urethral MRI sequences with an MR-guided radiotherapy system (MRgRT).

Methods: Eleven prostate cancer patients were scanned on a MRgRT system using optimized urethral 3D HASTE and 3D TSE. A resident radiation oncologist contoured the prostatic urethra on the patients' planning CT, diagnostic 3T T2w MRI, and both urethral MRIs. An attending radiation oncologist reviewed/edited the resident's contours and additionally contoured the prostatic urethra on the clinical planning MRgRT MRI (bSSFP). For each image, the resident radiation oncologist, attending radiation oncologist, and a senior medical physicist qualitatively scored the prostatic urethra visibility. Using MRgRT 3D HASTE-based contouring workflow as baseline, prostatic urethra contours drawn on CT, diagnostic MRI, clinical bSSFP and 3D TSE were evaluated relative to the contour on 3D HASTE using 95th percentile Hausdorff distance (HD95), mean-distance-to-agreement (MDA), and DICE coefficient. Additionally, prostatic urethra contrast-to-noise-ratios (CNR) were calculated for all images.

Results: For two out of three observers, the urethra visibility score for 3D HASTE was significantly higher than CT, and clinical bSSFP, but was not significantly different from diagnostic MRI. The mean HD95/MDA/DICE values were 11.35 ± 3.55 mm/5.77 ± 2.69 mm/0.07 ± 0.08 for CT, 7.62 ± 2.75 mm/3.83 ± 1.47 mm/0.12 ± 0.10 for CT + diagnostic MRI, 5.49 ± 2.32 mm/2.18 ± 1.19 mm/0.35 ± 0.19 for 3D TSE, and 6.34 ± 2.89 mm/2.65 ± 1.31 mm/0.21 ± 0.12 for clinical bSSFP. The CNR for 3D HASTE was significantly higher than CT, diagnostic MRI, and clinical bSSFP, but was not significantly different from 3D TSE.

Conclusion: The urethra's visibility scores showed optimized urethral MRgRT 3D HASTE was superior to the other tested methodologies. The prostatic urethra contours demonstrated significant variability from different imaging and workflows. Urethra contouring uncertainty introduced by cross-modality registration and sub-optimal imaging contrast may lead to significant treatment degradation when urethral sparing is implemented to minimize genitourinary toxicity.
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http://dx.doi.org/10.3390/cancers13143564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8307202PMC
July 2021

Irreversible Electroporation Treatment With Intraoperative Biliary Stenting for Unresectable Perihilar Cholangiocarcinoma: A Pilot Study.

Front Oncol 2021 30;11:710536. Epub 2021 Jun 30.

Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: Treating perihilar cholangiocarcinoma (PHCC) is particularly difficult due to the fact that it is usually in an advanced stage at the time of diagnosis. Irreversible electroporation treatment (IRE) involves the local administration of a high-voltage electric current to target lesions without causing damage to surrounding structures. This study investigated the safety and efficacy of using IRE in conjunction with intraoperative biliary stent placement in cases of unresectable PHCC.

Methods: This study enrolled 17 patients with unresectable Bismuth type III/IV PHCC who underwent IRE in conjunction with intraoperative biliary stent placement (laparotomic) in two medical centers in Asia between June 2015 and July 2018. Analysis focused on the perioperative clinical course, the efficacy of biliary decompression, and outcomes (survival).

Results: Mean total serum bilirubin levels (mg/dL) on postoperative day (POD) 7, POD30, and POD90 were significantly lower than before IRE (respectively 3.46 4.54, p=0.007; 1.21 vs 4.54, p<0.001; 1.99 4.54, p<0.001). Mean serum carbohydrate antigen 19-9 (CA19-9, U/ml) levels were significantly higher on POD3 than before the operation (518.8 372.4, p=0.001) and significantly lower on POD30 and POD90 (respectively 113.7 372.4, p<0.001; 63.9 372.4, p<0.001). No cases of Clavien-Dindo grade III/IV adverse events or mortality occurred within 90 days post-op. The median progression-free survival was 21.5 months, and the median overall survival was 27.9 months. All individuals who survived for at least one year did so without the need to carry percutaneous biliary drainage (PTBD) tubes.

Conclusions: It appears that IRE treatment in conjunction with intraoperative biliary stent placement is a safe and effective approach to treating unresectable PHCC. The decompression of biliary obstruction without the need for PTBD tubes is also expected to improve the quality of life of patients.
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http://dx.doi.org/10.3389/fonc.2021.710536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278819PMC
June 2021

Impact of Adjuvant Chemoradiotherapy on Survival of Resected Pancreatic Adenocarcinoma Cancer: A Surveillance, Epidemiology and End Results (SEER) Analysis.

Front Oncol 2021 1;11:651671. Epub 2021 Jul 1.

Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital, Wuhan University, Wuhan, China.

Background: The benefits of postoperative adjuvant chemoradiotherapy (CRT) for pancreatic cancer remain controversial. The purpose of this study is to determine if adjuvant CRT can improve the overall survival of postoperative pancreatic cancer patients compared to adjuvant chemotherapy (CT).

Methods: Patients with resected pancreas adenocarcinoma were identified in the Surveillance, Epidemiology, and End Results (SEER) database (2004-2016). Multivariate Cox regression was used to determine the factors related to survival rate. Selection bias was reduced to a minimum through propensity matching analysis. Subgroup analyses by clinical characteristics were performed.

Results: This study identified 10,097 patients who received adjuvant CT (n = 5,454) or adjuvant CRT (n = 4,643). On multivariate analysis, age, sex, tumor size, site, grade, stage, T stage, and lymph node metastasis were independent risk factors for OS. The basic clinical characteristics were well balanced after propensity matching. After propensity matching, CRT can improve the survival rate compared with CT [median OS: 22 months 23 months (HR, 0.928; 95% CI, 0.881-0.977; P = 0.004)]. Subgroup analysis indicated that the survival benefit of adjuvant chemoradiotherapy was more significant in patients with female (HR, 0.860; 95% CI, 0.798-0.926; P = 0.005 for interaction) or T3 (HR, 0.905; 95% CI, 0.855-0.957; P = 0.04 for interaction) or lymph nodes positive (HR, 0.883; 95% CI, 0.832-0.938; P = 0.005 for interaction).

Conclusion: Adjuvant CRT was associated with improved survival compared with adjuvant CT in patients with resection of pancreatic ductal adenocarcinoma. The benefit was more significant in patients with female or T3 or lymph nodes positive.
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http://dx.doi.org/10.3389/fonc.2021.651671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8281351PMC
July 2021

Associations of paternal and maternal per- and polyfluoroalkyl substances exposure with cord serum reproductive hormones, placental steroidogenic enzyme and birth weight.

Chemosphere 2021 Jul 12;285:131521. Epub 2021 Jul 12.

Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; MOE-Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200093, China. Electronic address:

Background: Maternal per- and polyfluoroalkyl substances (PFAS) exposure has been associated with placental function and fetal growth measures. However, few studies have simultaneously investigated paternal and maternal exposure effects.

Objectives: We evaluated the associations of paternal or maternal PFAS levels with placental function and fetal growth measures.

Methods: We studied six PFAS measured in matched parental serums collected within 3 days before delivery in a birth cohort from LaiZhouWan, China. Outcomes evaluated include cord serum estradiol (n = 351), testosterone (n = 349), placental P450aromatase (n = 125), and birth weight (n = 369). Multiple linear regression was applied to estimate the associations for these outcomes according to paternal or maternal PFAS level after adjusting for socio-demographic confounders. Co-adjustment analysis of both paternal and maternal PFAS in the same model was performed.

Results: Maternal and paternal PFAS levels were correlated (Spearman's r = 0.23-0.45). Maternal PFAS were associated with increased estradiol (e.g.

, Pfoa: β = 0.03, 95%CI: 0.00, 0.07), testosterone (e.g.

, Pfua: β = 0.14, 95%CI: 0.00, 0.27), and P450aromatase (e.g.

, Pfoa: β = 0.13, 95%CI: 0.04, 0.22). Maternal PFAS were also associated with a lower mean of birth weight but the estimated 95% CI included the null. Paternal PFAS were not associated with any of the outcomes evaluated.

Conclusions: Several maternal PFAS were associated with fetal steroid hormones and placental enzymes. Despite a correlation of PFAS level within the couples, no association was found for paternal PFAS exposure on these outcomes. The findings suggest the intrauterine PFAS exposure effect on fetal endocrine hormones and growth is unlikely to be confounded by exposure sources or familial factors shared within the couples.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131521DOI Listing
July 2021

Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2.

Cell Res 2021 Jul 15. Epub 2021 Jul 15.

Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global crisis, urgently necessitating the development of safe, efficacious, convenient-to-store, and low-cost vaccine options. A major challenge is that the receptor-binding domain (RBD)-only vaccine fails to trigger long-lasting protective immunity if used alone for vaccination. To enhance antigen processing and cross-presentation in draining lymph nodes (DLNs), we developed an interferon (IFN)-armed RBD dimerized by an immunoglobulin fragment (I-R-F). I-R-F efficiently directs immunity against RBD to DLNs. A low dose of I-R-F induces not only high titers of long-lasting neutralizing antibodies (NAbs) but also more comprehensive T cell responses than RBD. Notably, I-R-F provides comprehensive protection in the form of a one-dose vaccine without an adjuvant. Our study shows that the pan-epitope modified human I-R-F (I-P-R-F) vaccine provides rapid and complete protection throughout the upper and lower respiratory tracts against a high-dose SARS-CoV-2 challenge in rhesus macaques. Based on these promising results, we have initiated a randomized, placebo-controlled, phase I/II trial of the human I-P-R-F vaccine (V-01) in 180 healthy adults, and the vaccine appears safe and elicits strong antiviral immune responses. Due to its potency and safety, this engineered vaccine may become a next-generation vaccine candidate in the global effort to overcome COVID-19.
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http://dx.doi.org/10.1038/s41422-021-00531-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280646PMC
July 2021

Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair.

Genome Biol 2021 Jul 12;22(1):203. Epub 2021 Jul 12.

Department of Neurosciences and Developmental Biology, University of Vienna, 1090, Vienna, Austria.

Background: The origin of sex chromosomes requires the establishment of recombination suppression between the proto-sex chromosomes. In many fish species, the sex chromosome pair is homomorphic with a recent origin, providing species for studying how and why recombination suppression evolved in the initial stages of sex chromosome differentiation, but this requires accurate sequence assembly of the X and Y (or Z and W) chromosomes, which may be difficult if they are recently diverged.

Results: Here we produce a haplotype-resolved genome assembly of zig-zag eel (Mastacembelus armatus), an aquaculture fish, at the chromosomal scale. The diploid assembly is nearly gap-free, and in most chromosomes, we resolve the centromeric and subtelomeric heterochromatic sequences. In particular, the Y chromosome, including its highly repetitive short arm, has zero gaps. Using resequencing data, we identify a ~7 Mb fully sex-linked region (SLR), spanning the sex chromosome centromere and almost entirely embedded in the pericentromeric heterochromatin. The SLRs on the X and Y chromosomes are almost identical in sequence and gene content, but both are repetitive and heterochromatic, consistent with zero or low recombination. We further identify an HMG-domain containing gene HMGN6 in the SLR as a candidate sex-determining gene that is expressed at the onset of testis development.

Conclusions: Our study supports the idea that preexisting regions of low recombination, such as pericentromeric regions, can give rise to SLR in the absence of structural variations between the proto-sex chromosomes.
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http://dx.doi.org/10.1186/s13059-021-02430-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8273981PMC
July 2021

Identification of LecRLK gene family in Cerasus humilis through genomic-transcriptomic data mining and expression analyses.

PLoS One 2021 12;16(7):e0254535. Epub 2021 Jul 12.

College of Horticulture, Shanxi Agricultural University, Taigu, Shanxi, P. R. China.

Lectin receptor-like protein kinases (LecRLKs) have been shown to be involved in plants' responses to various biotic and abiotic stresse factors. Cerasus humilis is an important fruit species widely planted for soil and water conservation in northern China due to its strong tolerance to drought and salinity stresses. In this study, a total of 170 LecRLK family genes (125 G-types, 43 L-types and 2 C-types) were identified in the newly released whole-genome sequences of C. humilis. Furthermore, nine representative LecRLK genes in young plants of C. humilis under varying drought and salinity stresses were selected for qRT-PCR analysis. Our systematic comparative analyses revealed the active participation of these nine LecRLK genes in the salt and drought stress responses of C. humilis. The results from our study have provided a solid foundation for future functional verification of these LecRLK family genes and will likely help facilitate the more rapid and effective development of new stress resistant Cerasus humilis cultivars.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254535PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8274838PMC
July 2021

Microplastic pollution characteristic in surface water and freshwater fish of Gehu Lake, China.

Environ Sci Pollut Res Int 2021 Jul 10. Epub 2021 Jul 10.

School of Environmental & Safety Engineering, Changzhou University, Changzhou, 213164, Jiangsu, China.

Much more attention has been poured into microplastic pollution in freshwater systems recently. In the present study, the pollution of microplastics (MPs) in surface water and freshwater fish (crucian carp, etc.) were investigated from Gehu Lake, which is the second largest lake in southern Jiangsu after Taihu Lake. The result manifested that the average abundance of MPs was respectively 6.33±2.67 n/L for surface water and 10.7 items per individual for freshwater fish. The distribution of MPs in Gehu Lake varied from place to place, with the highest abundance of MPs was observed in the two estuaries of the eastern part of the lake. It was speculated that topographical factors and human factors were the main factors affecting the abundance and distribution of MPs. Transparent fibers were the main type of MPs in water samples, accounting for 69.70% of all detected particles. Meanwhile, most of the MPs ingested by freshwater fish were fibers, and the main colors were transparent and blue. In addition, the dominant size of the MPs was between 0.1 to 0.5 mm in water and fish samples. Moreover, PES, man-made fiber, and PP were the dominant polymer types in the surface water and fish samples. The results of this investigation can provide basic data for the research and management of MPs in freshwater systems.
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http://dx.doi.org/10.1007/s11356-021-15338-8DOI Listing
July 2021

A novel ratiometric fluorescent chemosensor for detecting malononitrile and application assisted with smartphone.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Dec 1;262:120135. Epub 2021 Jul 1.

Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, College of Light Industry and Food, Nanjing Forestry University, Nanjing 210037, China. Electronic address:

Malononitrile can be transformed into hypertoxic hydrogen cyanide which induces severely jeopardizes to human beings and environment. However, an effective detection technology for malononitrile was still lacking, which means that it is necessary to develop new sensitive analysis technology for malononitrile. Here in, a high sensitive fluorescent probe NQBS for detecting malononitrile was designed and synthesized from the derivative of natural product nopinone. NQBS could selectively recognize malononitrile from 26 kinds of competitive compounds in N, N-dimethylformamide (DMF) solution. The detection limit of NQBS for malononitrile was calculated to be 1.96 μM at the concentration range of 0-25 μM. In addition, the sensing mechanism of NQBS towards malononitrile was proved with high resolution mass spectrometer (HRMS), nuclear magnetic resonance hydrogen spectroscopy (H NMR), and density functional theory (DFT) calculation analysis as Knoevenagel condensation process and intramolecular cyclization reaction. With the assistance of smartphone and color recognition software, NQBS was well applied in the on-site recognition of malononitrile in real time by analyzing the change trend of the red-greenblue (RGB) value of the NQBS solution.
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http://dx.doi.org/10.1016/j.saa.2021.120135DOI Listing
December 2021

[Spectrum peak detection algorithm based on trend accumulation without base deduction].

Se Pu 2021 Jun;39(6):670-677

School of Energy and Environmental Engineering, University of Science and Technology Beijing, Beijing 100083, China.

The detection and analysis of spectral peaks play an important role in research on chromatography technology. However, in the process of collecting and transmitting chromatographic data, it is very difficult to detect spectral peaks owing to the interference of different levels of noise. Most of the traditional spectral peak detection algorithms follow three steps: spectral smoothing, baseline correction, and spectral peak recognition, which require high denoising and curve smoothing, and therefore increase the complexity of the algorithm. In addition, a traditional spectrum peak detection algorithm generally defines the shape of the spectrum peak by applying the base deduction method, and divides the spectrum peak into a single peak, overlapping peaks, and so on. Different detection methods are used for different types of spectral peaks, which lead to the shortcomings of traditional peak detection algorithms, such as high complexity, low automation, and susceptibility to distortion. Therefore, this study proposes a novel peak detection algorithm developed using a different point of view. The algorithm omits the base subtraction and spectral peak classification steps and instead detects spectral peaks directly based on the source data curve. In a traditional spectrum peak detection algorithm, the spectrum peak classification depends on determining a baseline. If the baseline is adjusted, the baseline will fit the spectrum peak more closely. At this time, the overlapping peaks can be regarded as two connected peaks. However, there is no so-called baseline in the source data curve, and therefore the proposed algorithm cannot classify the spectral peaks using the baseline approach. Instead, an obvious bulge or depression in the source curve is considered to be the spectral peak. This algorithm essentially performs three steps: discrete difference, trend accumulation, and searching for all peaks. First, the difference between adjacent data is obtained using a discrete difference process. The difference value is compared with 0, and either a 1 or -1 value is used to replace the difference value to reflect the data fluctuation trend. The signals representing the trend are accumulated, and the spectrum peak is located according to the sum of the accumulated signals. The algorithm uses three-point location; that is, the peak starting point, extreme point, and peak end point are used to describe the position of a spectral peak. Finally, according to the spectrum peaks obtained in the previous step, the magnitude of each peak is calculated, and the spectrum peaks are screened by a sorting method. In this manner, the algorithm skips the base subtraction part and obtains the spectrum peak directly. Therefore, to obtain the base part, the peak subtraction method is applied. This study used the C language to design and write the algorithm, and nitrogen adsorption and desorption chromatographic curves measured by several dynamic specific surface area analyzers were detected and analyzed. The results indicate that the proposed algorithm can accurately distinguish the peak part from the base part, and is robust to data curve burr, vibration, and other types of noise. The three-point location of the spectrum peak is very accurate and is not affected by its complex morphology. Therefore, it has strong universality. Compared with other algorithms, this algorithm has the advantages of accurate positioning, clear structure, and good stability and reliability. The application of the proposed peak detection methods such as base-free deduction and trend accumulation, in the adsorption and desorption chromatographic curve and has been proven effective in the determination of absorption and desorption chromatographic peaks.
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http://dx.doi.org/10.3724/SP.J.1123.2020.11009DOI Listing
June 2021

Interfractional Geometric Variations and Dosimetric Benefits of Stereotactic MRI Guided Online Adaptive Radiotherapy (SMART) of Prostate Bed after Radical Prostatectomy: Post-Hoc Analysis of a Phase II Trial.

Cancers (Basel) 2021 Jun 4;13(11). Epub 2021 Jun 4.

Department of Radiation Oncology, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

Purpose: To evaluate geometric variations of patients receiving stereotactic body radiotherapy (SBRT) after radical prostatectomy and the dosimetric benefits of stereotactic MRI guided adaptive radiotherapy (SMART) to compensate for these variations.

Materials/methods: The CTV and OAR were contoured on 55 MRI setup scans of 11 patients treated with an MR-LINAC and enrolled in a phase II trial of post-prostatectomy SBRT. All patients followed institutional bladder and rectum preparation protocols and received five fractions of 6-6.8 Gy to the prostate bed. Interfractional changes in volume were calculated and shape deformation was quantified by the Dice similar coefficient (DSC). Changes in CTV-V95%, bladder and rectum maximum dose, V32.5Gy and V27.5Gy were predicted by recalculating the initial plan on daily MRI. SMART was retrospectively simulated if the predicted dose exceeded pre-set criteria.

Results: The CTV volume and shape remained stable with a median volumetric change of 3.0% (IQR -3.0% to 11.5%) and DSC of 0.83 (IQR 0.79 to 0.88). Relatively large volumetric changes in bladder (median -24.5%, IQR -34.6% to 14.5%) and rectum (median 5.4%, IQR - 9.7% to 20.7%) were observed while shape changes were moderate (median DSC of 0.79 and 0.73, respectively). The median CTV-V95% was 98.4% (IQR 94.9% to 99.6%) for the predicted doses. However, SMART would have been deemed beneficial for 78.2% of the 55 fractions based on target undercoverage (16.4%), exceeding OAR constraints (50.9%), or both (10.9%). Simulated SMART improved the dosimetry and met dosimetric criteria in all fractions. Moderate correlations were observed between the CTV-V95% and target DSC (R2 = 0.73) and bladder mean dose versus volumetric changes (R2 = 0.61).

Conclusions: Interfractional dosimetric variations resulting from anatomic deformation are commonly encountered with post-prostatectomy RT and can be mitigated with SMART.
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http://dx.doi.org/10.3390/cancers13112802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200117PMC
June 2021

A remotely-delivered community action project to promote a diabetes lifestyle intervention programme in northwest London: basis, process and outcomes.

Health Promot Perspect 2021 19;11(2):250-255. Epub 2021 May 19.

Eastbury Surgery, Northwood, London, UK.

: The prevalence of type 2 diabetes mellitus (T2DM) in London is rising, obesity being a major driver. As part of a primary care placement, the authors (two medical students and a lead general practitioner) directly promoted the Reducing Weight with Intensive Dietary Support (REWIND) programme to patients in Northwest London and collected feedback on the promotion. : The team developed and delivered three remote interventions: a redesigned patient-facing information leaflet, phone calls and text messages, and a live, interactive webinar, to directly engage patients and raise awareness about REWIND. Feedback was collected pre and post-webinar using an anonymised, online survey (essentially functioning as a 'teaching' evaluation). : Mean interest in REWIND had increased from 2.7 (pre-promotion) to 4.7 (post-promotion), knowledge about REWIND had increased from 2.1 to 4, and self-reported likelihood of enrolling had increased from 2.6 to 4.2 (P<0.01 in all cases). The reported usefulness of the leaflet and webinar was scored 3.7 and 4.4 respectively. Within two weeks of the webinar, two of these patients had joined . : Feedback from the patients and GP revealed that the project successfully raised awareness, improved knowledge, and increased the likelihood of enrolment in REWIND. Diabetes programmes and organisations are encouraged to adapt the methods of this project to their own contexts, especially in light of COVID-19 where remote interventions will remain essential.
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http://dx.doi.org/10.34172/hpp.2021.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8233682PMC
May 2021

Association of lung function with functional limitation in older adults: A cross-sectional study.

PLoS One 2021 29;16(6):e0253606. Epub 2021 Jun 29.

Department of Epidemiology and Health Statistics, The School of Public Health, Qingdao University, Qingdao, Shandong, China.

Introduction: Impaired lung function is independently associated with higher rates of disability, however, few studies have examined the association between lung function and functional limitation. This study aimed to assess this association and dose-response relationship in older adults.

Methods: Data from the National Health and Nutrition Examination Survey (2007-2012) was used as a cross-sectional study. Lung function was determined by Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC). Functional limitation in older adults was identified by six self-reported questions on physical function. 3070 adults aged 60 and over were enrolled in our study. Logistic regression models and restricted cubic spline models were applied to examine the association between lung function and the risk of functional limitation.

Results: FEV1 and FVC were inversely associated with the risk of functional limitation. In the full adjusted model, compared with the lowest tertile of FEV1, the odds ratios (95% confidence intervals) of functional limitation for tertile 2 and tertile 3 were 0.5422 (0.3848-0.7639) and 0.4403 (0.2685-0.7220), and the odds ratios (95% confidence intervals) of functional limitation for tertile 2 and tertile 3 of FVC were 0.5243 (0.3503-0.7848) and 0.3726 (0.2072-0.6698). Furthermore, an inverse association persisted after stratified analysis by gender and sensitivity analysis. Dose-response analyses showed that the odds of functional limitation declined with increase in FEV1 and FVC in a nonlinear manner.

Conclusions: Lung function was inversely associated with functional limitation among older adults.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253606PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241026PMC
June 2021

Differences in berry skin and pulp cell wall polysaccharides from ripe and overripe Shiraz grapes evaluated using glycan profiling reveals extensin-rich flesh.

Food Chem 2021 May 24;363:130180. Epub 2021 May 24.

South African Grape and Wine Research Institute, Department of Viticulture and Oenology, Faculty of AgriSciences, Stellenbosch University, Matieland 7602, South Africa. Electronic address:

Shiraz is a widely planted cultivar in many of the world's top wine regions where it is used for the production of top-quality single varietal or blended red wines. Cell wall changes during grape ripening and over-ripening have been investigated, particularly in the context of understanding berry deconstruction thereby facilitating the release of favorable compounds during winemaking. However, no information is available on cell wall changes during berry shrinkage in Shiraz. Glycan microarray technology was used to directly profile Shiraz berries for cell wall polysaccharide and glycoprotein epitopes. Skins and pulp tissues were profiled separately and revealed that whereas the skin was rich in pectins and xyloglucans, the pulp tissues were mainly composed of extensin glycoproteins. Overripe (26-28°B) berries, particularly those from the warmer region site, revealed degradation of their pectin and extensin epitopes.
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http://dx.doi.org/10.1016/j.foodchem.2021.130180DOI Listing
May 2021

Bioinformatics Analysis of Differentially Expressed Rhythm Genes in Liver Hepatocellular Carcinoma.

Front Genet 2021 3;12:680528. Epub 2021 Jun 3.

School of Life Sciences, Bengbu Medical College, Bengbu, China.

Liver Hepatocellular Carcinoma (LIHC), a malignant tumor with high incidence and mortality, is one of the most common cancers in the world. Multiple studies have found that the aberrant expression of rhythm genes is closely related to the occurrence of LIHC. This study aimed to use bioinformatics analysis to identify differentially expressed rhythm genes (DERGs) in LIHC. A total of 563 DERGs were found in LIHC, including 265 downregulated genes and 298 upregulated genes. KEGG pathway enrichment and GO analyses showed that DERGs were significantly enriched in rhythmic and metabolic processes. Survival analysis revealed that high expression levels of , , and S2 were significantly associated with the low survival rate in LIHC patients. Through cell experiment verification, the mRNA expression levels of , , and were found to be strongly upregulated, which was consistent with the bioinformatics analysis of LIHC patient samples. A total of 23 nodes and 135 edges were involved in the protein-protein interaction network of , , and genes. Clinical correlation analyses revealed that , , and expression levels were high-risk factors and independently connected with the overall survival rate in LIHC patients. In conclusion, the identification of these DERGs contributes to the exploration of the molecular mechanisms of LIHC occurrence and development and may be used as diagnostic and prognostic biomarkers and molecular targets for chronotherapy in LIHC patients in the future.
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http://dx.doi.org/10.3389/fgene.2021.680528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211427PMC
June 2021

Water management of alternate wetting and drying combined with phosphate application reduced lead and arsenic accumulation in rice.

Chemosphere 2021 Jun 11;283:131043. Epub 2021 Jun 11.

Key Laboratory for Water Pollution Control and Environmental Safety, Zhejiang University, Hangzhou, 310058, China; Department of Environmental Engineering, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China. Electronic address:

Lead (Pb) and arsenic (As) exist in soil with different ionic forms, and it is difficult to immobilize simultaneously Pb and As in soil. The objective of this study is to determine the effects of water management including flooding (FL), alternate wetting and drying (AWD) and dry farming (DF) combined with addition of phosphate (P) on the accumulation of Pb and As in rice. Our results showed that Pb accumulated in root during vegetative stage, and most of As in root was transported to the above ground parts during the reproductive stage. Pb was evenly distributed in grains, and As was mostly accumulated in bran and aleurone layer. Water management had a reverse effect on the accumulation of Pb and As in rice. However, the effects of P on arid soil environment and Pb, As accumulation in rice were stronger than that in flooded soil. Application of P under AWD treatment could maintain a similar quantity of Fe plaque with flooding, decrease the availability of Pb in rhizosphere soil, reduce Pb and As accumulation in root, and result in the reduction of Pb and As accumulation in grains by 86% and 66% respectively. Besides, our study also found that flooding or AWD during vegetative stage facilitated the formation of iron plaque. In conclusion, AWD combined with P application could maintain a relatively lower concentrations of Pb and As in grains.
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http://dx.doi.org/10.1016/j.chemosphere.2021.131043DOI Listing
June 2021

Algorithm optimization of cross-interfaces computed tomography into full field.

Appl Opt 2021 May;60(15):4469-4476

Tomographic approaches in confined space require advanced imaging algorithms that can properly consider the refractive distortion as the imaging rays pass through the optical wall. Our previous work established an algorithm (cross-interfaces computed tomography, CICT) and practically solved tomographic problems in confined space. However, critical restriction was found in CICT, which is that images simulated at small azimuth angles are contaminated with noticeable signal loss and become unusable. Based on this recognition, this work has developed an improved tomography approach, namely, full-field cross-interfaces computed tomography (FCICT), to extend the available view angles to all perspectives. The key to this approach involves the 3D domain discretization using voxel parallelepipeds instead of traditional voxel layers to establish the ray-tracing relationship between imaging planes and the measurement domain. The imaging process of FCICT is first validated by quantitatively comparing the grid imaging locations in measured and simulated projections of a calibration plate. By evenly distributing the view angles in the whole azimuth angle range, the FCICT reconstruction is then numerically validated by reconstructing a simulated double-cone flame phantom. The reconstruction presents a high correlation coefficient of ${\sim}{98}\%$ with the original phantom. Finally, the FCICT is employed to reconstruct an ethylene-air premixed flame. Comparisons show that re-projections generated by the FCICT reconstruction are in accordance with measured flame images, with the mean correlation coefficients of more than 95%.
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http://dx.doi.org/10.1364/AO.425829DOI Listing
May 2021

Diabetic Endothelial Cells Differentiated From Patient iPSCs Show Dysregulated Glycine Homeostasis and Senescence Associated Phenotypes.

Front Cell Dev Biol 2021 31;9:667252. Epub 2021 May 31.

National Heart Centre Singapore, National Heart Research Institute Singapore, Singapore, Singapore.

Induced pluripotent stem cells derived cells (iPSCs) not only can be used for personalized cell transfer therapy, but also can be used for modeling diseases for drug screening and discovery Although prior studies have characterized the function of rodent iPSCs derived endothelial cells (ECs) in diabetes or metabolic syndrome, feature phenotypes are largely unknown in hiPSC-ECs from patients with diabetes. Here, we used hiPSC lines from patients with type 2 diabetes mellitus (T2DM) and differentiated them into ECs (dia-hiPSC-ECs). We found that dia-hiPSC-ECs had disrupted glycine homeostasis, increased senescence, and impaired mitochondrial function and angiogenic potential as compared with healthy hiPSC-ECs. These signature phenotypes will be helpful to establish dia-hiPSC-ECs as models of endothelial dysfunction for understanding molecular mechanisms of disease and for identifying and testing new targets for the treatment of endothelial dysfunction in diabetes.
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http://dx.doi.org/10.3389/fcell.2021.667252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201091PMC
May 2021

STING Contributes to Host Defense Against Pneumonia Through Suppressing Necroptosis.

Front Immunol 2021 31;12:636861. Epub 2021 May 31.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

STING (Stimulator of interferon genes) is known as an important adaptor protein or direct sensor in the detection of nucleotide originating from pathogens or the host. The implication of STING during pulmonary microbial infection remains unknown to date. Herein, we showed that STING protected against pulmonary infection by suppressing necroptosis. STING deficiency resulted in increased mortality, more bacteria burden in BALF and lungs, severe destruction of lung architecture, and elevated inflammatory cells infiltration and inflammatory cytokines secretion. STING deficiency also had a defect in bacterial clearance, but did not exacerbate pulmonary inflammation during the early stage of infection. Interestingly, TUNEL staining and LDH release assays showed that STING mice had increased cell death than WT mice. We further demonstrated that STING mice had decreased number of macrophages accompanied by increased dead macrophages. Our and findings further demonstrated this cell death as necroptosis. The critical role of necroptosis was detected by the fact that MLKL mice exhibited decreased macrophage death and enhanced host defense to infection. Importantly, blocking necroptosis activation rescued host defense defect against pneumonia in STING mice. Hence, these results reveal an important role of STING in suppressing necroptosis activation to facilitate early pathogen control during pulmonary infection.
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http://dx.doi.org/10.3389/fimmu.2021.636861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202078PMC
May 2021

Correction to: Ectopic overexpression of a type-II DGAT (CeDGAT2-2) derived from oil-rich tuber of Cyperus esculentus enhances accumulation of oil and oleic acid in tobacco leaves.

Biotechnol Biofuels 2021 Jun 16;14(1):139. Epub 2021 Jun 16.

College of Agriculture, Institute of Molecular Agriculture and Bioenergy, Shanxi Agricultural University, Taigu, 030801, Shanxi, China.

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http://dx.doi.org/10.1186/s13068-021-01990-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8210380PMC
June 2021

Resting Heart Rate Mediates the Relationship between Parenting Style and Callous-Unemotional Traits in Chinese Children.

Res Child Adolesc Psychopathol 2021 Jun 14. Epub 2021 Jun 14.

Department of Psychology, Guangzhou University, Guangzhou, P. R. China.

Despite increasing knowledge of social and biological risk factors for callous-unemotional (CU) traits, relatively less is known about how these two sets of risk factors combine to affect these traits. The current longitudinal study investigated pathways from parenting style to CU traits via resting heart rate in a three-year project. Parents of 382 children completed the Parenting Styles and Dimensions Questionnaire at Time 1 (children Mean age = 9.06, SD = 0.94, range = 7-11 years), with the heart rate data collected at Time 2 (M = 10.16, SD = 0.93, range = 8-13 years) and CU traits assessed at Time 3 (M = 11.06, SD = 0.94, range = 9-13 years). We found that parenting style and CU traits were associated with resting heart rate, and that structural equation modeling showed resting heart rate to partially mediate the effect of parenting style on CU traits. Specifically, higher levels of authoritarian parenting were associated with lower resting heart rate, which in turn was linked to higher level of CU traits. On the contrary, children in the context of authoritative parenting showed relatively higher resting heart rate, which was predictive of lower CU traits. Overall, findings have implications for understanding the etiology of CU traits in children and developing effective prevention programs for children with affective deficits.
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http://dx.doi.org/10.1007/s10802-021-00834-9DOI Listing
June 2021

Dual-Emission Ratiometric Fluorescent Probe Based on Lanthanide-Functionalized Carbon Quantum Dots for White Light Emission and Chemical Sensing.

ACS Omega 2021 Jun 27;6(22):14629-14638. Epub 2021 May 27.

School of Materials Science & Engineering, University of Shanghai for Science and Technology, Shanghai 200093, P. R. China.

Herein, we develop a novel method to synthesize lanthanide-functionalized carbon quantum dots via free-radical copolymerization using the methyl methacrylate (MMA) monomer as a functional monomer and introducing a lanthanide complex to obtain the dual-emission fluorescent composite material FCQDs-Ln(TFA) (Ln = Eu, Tb; TFA: trifluoroacetylacetone). The obtained composites were fully characterized, and their structures were investigated by Fourier transform infrared spectroscopy (FTIR), H NMR spectroscopy, X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). Subsequently, a series of white-light-emitting polymer composite films FCQDs- (Eu:Tb)(TFA)/poly(methyl methacrylate) (PMMA) were designed and synthesized by adjusting the ratio of Eu(TFA)/Tb(TFA) under different wavelengths. More significantly, FCQDs-Tb(TFA) was selected as a sensitive probe for sensing metal cations due to excellent photoluminescence properties, revealing a unique capability of FCQDs-Tb(TFA) of detecting Fe(III) cations with high efficiency and selectivity. Furthermore, the sensing experiment results indicated that FCQDs-Tb(TFA) is ideal as a fluorescent nanoprobe for Fe ion detection, and the lowest detection limit for Fe is 0.158 μM, which is superior to many other previous related research studies. This pioneering work provides a new idea and method for constructing a dual-emission ratio sensor based on carbon quantum dots and also extends the potential application in the biological and environmental fields.
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http://dx.doi.org/10.1021/acsomega.1c01745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190926PMC
June 2021

Magneto-sonothrombolysis with combination of magnetic microbubbles and nanodroplets.

Ultrasonics 2021 Jun 6;116:106487. Epub 2021 Jun 6.

Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA. Electronic address:

This paper reports a novel technique using the rotational magnetic field oscillation and low-intensity sub-megahertz ultrasound stimulation of magnetic microbubbles (MMBs) to promote the nanodroplets (NDs) phase transition and improve the permeation of NDs into the blood clot fibrin network to enhance the sonothrombolysis efficiency. In this study, the influence of different treatment methods with a combination of MMBs and NDs on the thrombolysis rate of both unretracted and retracted clots were investigated, including the stable and inertial cavitation, tPA effects, MMBs/NDs concentration ratio, sonication factors (input voltage, duty cycle) and rotational magnetic field factors (flux density, frequency). We demonstrated that tPA-mediated magneto-sonothrombolysis in combining NDs with MMBs could significantly enhance in vitro lysis of both unretracted clots (85 ± 8.3%) and retracted clots (57 ± 6.5%) in a flow model with 30 min treatment. The results showed that the combination of MMBs and NDs substantially improves in vitro lysis of blood clots with an unprecedented lysis rate.
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http://dx.doi.org/10.1016/j.ultras.2021.106487DOI Listing
June 2021

Treatments for Endometritis in Mares Caused by Streptococcus equi Subspecies zooepidemicus: A Structured Literature Review.

J Equine Vet Sci 2021 07 24;102:103430. Epub 2021 Feb 24.

College of Animal Science and Technology, China Agriculture University, Beijing, China. Electronic address:

Bacterial infections are the main causes of endometritis in mares. It is well known that the most common bacterial pathogen is Streptococcus equi subspecies zooepidemicus (SEZ). This structured review was completed according to the PRISMA procedure to search endometritis treatment protocols published between 1990 and 2020 it was our intent to evaluate the actual effects of different treatment protocols for endometritis caused by SEZ. The trials included were collected from Pubmed, CAB and Agricola. Ten articles with 116 horses and 17 different interventions were identified. The results of this structured review indicated that the reported antibiotics, immunomodulatory agents and fresh white blood cell treatments were superior for treating SEZ caused endometritis in mares, whereas oxytocin and uterine lavage alone may not be as effective as presumed. The inclusion and evaluation of more randomized controlled trials may be helpful for further elucidation of the differences.
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http://dx.doi.org/10.1016/j.jevs.2021.103430DOI Listing
July 2021

Solution combustion synthesis of a nanometer-scale CoO anode material for Li-ion batteries.

Beilstein J Nanotechnol 2021 10;12:424-431. Epub 2021 May 10.

Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, Poland.

A novel solution combustion synthesis of nanoscale spinel-structured CoO powder was proposed in this work. The obtained material was composed of loosely arranged nanoparticles whose average diameter was about 36 nm. The as-prepared cobalt oxide powder was also tested as the anode material for Li-ion batteries and revealed specific capacities of 1060 and 533 mAh·g after 100 cycles at charge-discharge current densities of 100 and 500 mA·g, respectively. Moreover, electrochemical measurements indicate that even though the synthesized nanomaterial possesses a low active surface area, it exhibits a relatively high specific capacity measured at 100 mA·g after 100 cycles and a quite good rate capability at current densities between 50 and 5000 mA·g.
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http://dx.doi.org/10.3762/bjnano.12.34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144916PMC
May 2021

Circ-RNA Expression Pattern and circ-RNA-miRNA-mRNA Network in The Pathogenesis of Human Intervertebral Disc Degeneration.

Cell J 2021 Jul 26;23(2):218-224. Epub 2021 May 26.

Clinical Medical College, Weifang Medical University, Weifang 261053, Shandong, China.

Objective: The present study aimed to screen the differentially expressed (DE) circular RNAs (circ-RNAs) between lumbar intervertebral disc degeneration (IVDD) and normal tissues.

Materials And Methods: In this experimental study, microarray hybridization was performed to evaluate circ-RNA expression, and the DE circ-RNAs were confirmed by quantitative real-time polymerase chain reaction (qRT-PCR). Host genes of DE circ-RNAs were predicted, and their functions were evaluated. Further, a competitive endogenesis (ce) RNA network among 4 DE circ-RNAs-miRNA-mRNA was constructed by Cytoscape.

Results: A total of 2636 circ-RNAs were detected in all samples; among them, 89.23% were exonic circ-RNAs. There were 138 DE circ-RNAs, including 134 up-regulated circ-RNAs and 4 downregulated circ-RNAs in IVDD samples. qRT-PCR validation experiments showed that expression trends of hsa_circ_0003239, hsa_circ_0003162, hsa_circ_0005918, and hsa_circ_0005556 were in line with the microarray analysis results. Functional enrichment analysis showed that host genes of DE circ-RNAs significantly disturbed pathways of regulation of actin cytoskeleton, propanoate metabolism, and ErbB signaling pathway. The four DE circ-RNAs related ceRNA network was constructed.

Conclusion: Our results revealed that circ-RNAs can function as miRNA sponges and regulate parent gene expression to affect IVDD.
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http://dx.doi.org/10.22074/cellj.2021.6832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181320PMC
July 2021

Helper T Cells in Idiopathic Membranous Nephropathy.

Front Immunol 2021 20;12:665629. Epub 2021 May 20.

Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, China.

Idiopathic membranous nephropathy (IMN) is an autoimmune disease in which the immune system produces an antibody response to its own antigens due to impaired immune tolerance. Although antibodies are derived from plasma cells differentiated by B cells, the T-B cells also contribute a lot to the immune system. In particular, the subsets of helper T (Th) cells, including the dominant subsets such as Th2, Th17, and follicular helper T (Tfh) cells and the inferior subsets such as regulatory T (Treg) cells, shape the immune imbalance of IMN and promote the incidence and development of autoimmune responses. After reviewing the physiological knowledge of various subpopulations of Th cells and combining the existing studies on Th cells in IMN, the role model of Th cells in IMN was explained in this review. Finally, the existing clinical treatment regimens for IMN were reviewed, and the importance of the therapy for Th cells was highlighted.
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http://dx.doi.org/10.3389/fimmu.2021.665629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8173183PMC
May 2021

Effect of Different Plants on the Growth and Reproduction of (Thysanoptera: Thripidae).

Insects 2021 May 28;12(6). Epub 2021 May 28.

College of Plant Protection, Jilin Agricultural University, Changchun 130118, China.

Host plants play an important role in affecting insect development and reproduction. Understanding the host plant preferences is important for pest control. Schrank (Thysanoptera: Thripidae) is a worldwide phytophagous pest in Palearctic Asian and European countries. We used a life table analysis to study the development duration, population parameters, and population growth of on five plant species, including (Solanaceae), (Solanaceae), (Leguminosae), var. (Cruciferae), and (Cucurbitaceae). The results showed that can survive and reproduce on and , which were two potentially suitable host plants. preferred to oviposit on with a shorter duration of development (17.8 days) at 25 °C. Therefore, the host plant was an important factor influencing the development and fecundity of populations. These results will improve our understanding of the population dynamics of and facilitate the development of more scientific and efficient measures to control thrips.
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http://dx.doi.org/10.3390/insects12060502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8228280PMC
May 2021
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