Publications by authors named "Ype Elgersma"

89Publications

Clinical aspects of a large group of adults with Angelman syndrome.

Am J Med Genet A 2020 Oct 27. Epub 2020 Oct 27.

Intellectual Disability Medicine, Department of General Practice, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/ajmg.a.61940DOI Listing
October 2020

Motor cortical excitability and plasticity in patients with neurofibromatosis type 1.

Clin Neurophysiol 2020 Nov 11;131(11):2673-2681. Epub 2020 Sep 11.

Department of Neuroscience, Erasmus Medical Center, Rotterdam, the Netherlands; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2020.08.016DOI Listing
November 2020

How the COVID-19 pandemic highlights the necessity of animal research.

Curr Biol 2020 09 10;30(18):R1014-R1018. Epub 2020 Aug 10.

Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2020.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416712PMC
September 2020

Assessing the requirements of prenatal UBE3A expression for rescue of behavioral phenotypes in a mouse model for Angelman syndrome.

Mol Autism 2020 Sep 18;11(1):70. Epub 2020 Sep 18.

Department of Neuroscience and the ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC University Medical Center, 3015 CN, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13229-020-00376-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7501605PMC
September 2020

Conserved UBE3A subcellular distribution between human and mice is facilitated by non-homologous isoforms.

Hum Mol Genet 2020 Sep 2. Epub 2020 Sep 2.

Department of Neuroscience, Erasmus MC University Medical Center, Rotterdam, 3015 CN, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddaa194DOI Listing
September 2020

Angelman Syndrome: From Mouse Models to Therapy.

Neuroscience 2020 Oct 21;445:172-189. Epub 2020 Feb 21.

Department of Neuroscience, The ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC University Medical Center, Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2020.02.017DOI Listing
October 2020

Considerations for Clinical Therapeutic Development of Statins for Neurodevelopmental Disorders.

eNeuro 2020 Mar/Apr;7(2). Epub 2020 Mar 6.

Department of Neuroscience, ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus Medical Center, 3015 GD, Rotterdam, The Netherlands

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http://dx.doi.org/10.1523/ENEURO.0392-19.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070444PMC
March 2020

The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.

Mol Autism 2019 29;10:41. Epub 2019 Nov 29.

Istituto Nanoscienze- Consiglio Nazionale delle Ricerche (CNR) & Scuola Normale Superiore, NEST, Piazza San Silvestro 12, 56127 Pisa, Italy.

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http://dx.doi.org/10.1186/s13229-019-0293-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884852PMC
June 2020

Netrin-G2 dysfunction causes a Rett-like phenotype with areflexia.

Hum Mutat 2020 Feb 15;41(2):476-486. Epub 2019 Nov 15.

Pediatric Neurology Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat Gan, Israel.

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http://dx.doi.org/10.1002/humu.23945DOI Listing
February 2020

Effects of antiepileptic drugs in a new TSC/mTOR-dependent epilepsy mouse model.

Ann Clin Transl Neurol 2019 07 24;6(7):1273-1291. Epub 2019 Jun 24.

Department of Neuroscience and ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC University Medical Center, Rotterdam, 3015 CN, The Netherlands.

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http://dx.doi.org/10.1002/acn3.50829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649373PMC
July 2019

A randomized controlled trial with everolimus for IQ and autism in tuberous sclerosis complex.

Neurology 2019 07 19;93(2):e200-e209. Epub 2019 Jun 19.

From the ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., S.E.M., K.B.-d.H., L.W.t.H., T.v.d.V., Y.E., H.A.M., M.-C.Y.d.W.) and Departments of Neurology (I.E.O., T.v.d.V., M.-C.Y.d.W.), Child and Adolescent Psychiatry and Psychology (A.B.R., S.E.M., L.W.t.H.), and Pediatrics (K.B.-d.H., H.A.M.), Erasmus MC-Sophia Children's Hospital; Departments of Biostatistics (D.R.) and Neuroscience (Y.E.), Erasmus MC, Rotterdam; and Department of Child Neurology (F.E.J.), Brain Centre Rudolf Magnus, University Medical Centre Utrecht, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000007749DOI Listing
July 2019

Delayed loss of UBE3A reduces the expression of Angelman syndrome-associated phenotypes.

Mol Autism 2019 22;10:23. Epub 2019 May 22.

1Department of Neuroscience and the ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC University Medical Center, 3015 CN Rotterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13229-019-0277-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532248PMC
June 2020

From process to progress-2017 International Conference on Neurofibromatosis 1, Neurofibromatosis 2 and Schwannomatosis.

Am J Med Genet A 2019 06 25;179(6):1098-1106. Epub 2019 Mar 25.

Division of Neuroscience, Oregon National Primate Research Center, and Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.

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http://dx.doi.org/10.1002/ajmg.a.61112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488427PMC
June 2019

Adult Gene Reinstatement Restores the Electrophysiological Deficits of Prefrontal Cortex Layer 5 Neurons in a Mouse Model of Angelman Syndrome.

J Neurosci 2018 09 6;38(37):8011-8030. Epub 2018 Aug 6.

Department of Neuroscience and ENCORE Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands

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http://dx.doi.org/10.1523/JNEUROSCI.0083-18.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6596147PMC
September 2018

Enhanced Transmission at the Calyx of Held Synapse in a Mouse Model for Angelman Syndrome.

Front Cell Neurosci 2017 4;11:418. Epub 2018 Jan 4.

Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fncel.2017.00418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758499PMC
January 2018

Modulation of Murine Olivary Connexin 36 Gap Junctions by PKA and CaMKII.

Front Cell Neurosci 2017 14;11:397. Epub 2017 Dec 14.

Department of Neuroscience, Erasmus Medical Center, Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fncel.2017.00397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735106PMC
December 2017

Improvement of ubiquitylation site detection by Orbitrap mass spectrometry.

J Proteomics 2018 02 6;172:49-56. Epub 2017 Nov 6.

Proteomics Center, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jprot.2017.10.014DOI Listing
February 2018

De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability.

Authors:
Sébastien Küry Geeske M van Woerden Thomas Besnard Martina Proietti Onori Xénia Latypova Meghan C Towne Megan T Cho Trine E Prescott Melissa A Ploeg Stephan Sanders Holly A F Stessman Aurora Pujol Ben Distel Laurie A Robak Jonathan A Bernstein Anne-Sophie Denommé-Pichon Gaëtan Lesca Elizabeth A Sellars Jonathan Berg Wilfrid Carré Øyvind Løvold Busk Bregje W M van Bon Jeff L Waugh Matthew Deardorff George E Hoganson Katherine B Bosanko Diana S Johnson Tabib Dabir Øystein Lunde Holla Ajoy Sarkar Kristian Tveten Julitta de Bellescize Geir J Braathen Paulien A Terhal Dorothy K Grange Arie van Haeringen Christina Lam Ghayda Mirzaa Jennifer Burton Elizabeth J Bhoj Jessica Douglas Avni B Santani Addie I Nesbitt Katherine L Helbig Marisa V Andrews Amber Begtrup Sha Tang Koen L I van Gassen Jane Juusola Kimberly Foss Gregory M Enns Ute Moog Katrin Hinderhofer Nagarajan Paramasivam Sharyn Lincoln Brandon H Kusako Pierre Lindenbaum Eric Charpentier Catherine B Nowak Elouan Cherot Thomas Simonet Claudia A L Ruivenkamp Sihoun Hahn Catherine A Brownstein Fan Xia Sébastien Schmitt Wallid Deb Dominique Bonneau Mathilde Nizon Delphine Quinquis Jamel Chelly Gabrielle Rudolf Damien Sanlaville Philippe Parent Brigitte Gilbert-Dussardier Annick Toutain Vernon R Sutton Jenny Thies Lisenka E L M Peart-Vissers Pierre Boisseau Marie Vincent Andreas M Grabrucker Christèle Dubourg Wen-Hann Tan Nienke E Verbeek Martin Granzow Gijs W E Santen Jay Shendure Bertrand Isidor Laurent Pasquier Richard Redon Yaping Yang Matthew W State Tjitske Kleefstra Benjamin Cogné Slavé Petrovski Kyle Retterer Evan E Eichler Jill A Rosenfeld Pankaj B Agrawal Stéphane Bézieau Sylvie Odent Ype Elgersma Sandra Mercier

Am J Hum Genet 2017 Nov;101(5):768-788

CHU Nantes, Service de Génétique Médicale, 9 quai Moncousu, 44093 Nantes Cedex 1, France.

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http://dx.doi.org/10.1016/j.ajhg.2017.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673671PMC
November 2017

A brain proteomic investigation of rapamycin effects in the mouse model.

Mol Autism 2017 1;8:41. Epub 2017 Aug 1.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QT UK.

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http://dx.doi.org/10.1186/s13229-017-0151-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5540199PMC
April 2018

loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice.

J Neurophysiol 2017 07 3;118(1):634-646. Epub 2017 May 3.

Curriculum in Neurobiology, University of North Carolina, Chapel Hill, North Carolina;

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http://dx.doi.org/10.1152/jn.00618.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5511875PMC
July 2017

Calcium threshold shift enables frequency-independent control of plasticity by an instructive signal.

Proc Natl Acad Sci U S A 2016 11 31;113(46):13221-13226. Epub 2016 Oct 31.

Department of Neurobiology, University of Chicago, Chicago, IL 60637;

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http://dx.doi.org/10.1073/pnas.1613897113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135319PMC
November 2016

Sirolimus for epilepsy in children with tuberous sclerosis complex: A randomized controlled trial.

Neurology 2016 Sep 10;87(10):1011-8. Epub 2016 Aug 10.

From the Departments of Neurology (I.E.O., A.B.R., M.-C.Y.d.W.), Pediatrics (K.B.-d.H., H.A.M.), Public Health (C.W.N.L.), Biostatistics (D.R.), Neurophysiology (T.M.S., P.J.C.), and Neuroscience (Y.E.), ENCORE Expertise Centre for Neurodevelopmental Disorders (I.E.O., A.B.R., K.B.-d.H., H.A.M., Y.E., M.-C.Y.d.W.), Erasmus University Medical Centre, Rotterdam; and the Department of Pediatric Neurology (F.E.J.), Brain Center Rudolf Magnus, University Medical Centre Utrecht, the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000003077DOI Listing
September 2016

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.

Neuron 2016 Apr 24;90(1):56-69. Epub 2016 Mar 24.

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC 27599, USA; Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27599, USA; Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina, Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.02.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824651PMC
April 2016

Behavioral and cognitive outcomes for clinical trials in children with neurofibromatosis type 1.

Neurology 2016 Jan 30;86(2):154-60. Epub 2015 Oct 30.

From the Departments of Neuroscience (T.v.d.V., Y.E.), Pediatrics (T.v.d.V., H.A.M.), and Neurology (A.B.R.), and ENCORE-Expertise Center for Neurodevelopmental Disorders (T.v.d.V., A.B.R., Y.E., H.A.M.), Erasmus MC: University Medical Centre, Rotterdam, the Netherlands; the Department of Human Genetics (E.P., E.L.), Catholic University Leuven; and the Centre for Human Genetics at University Hospital Leuven (E.P., E.L.), Belgium.

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http://dx.doi.org/10.1212/WNL.0000000000002118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731686PMC
January 2016

An essential role for UBE2A/HR6A in learning and memory and mGLUR-dependent long-term depression.

Hum Mol Genet 2016 Jan 16;25(1):1-8. Epub 2015 Oct 16.

Department of Neuroscience, ENCORE Expertise Centre for Neurodevelopmental Disorders, and

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http://dx.doi.org/10.1093/hmg/ddv436DOI Listing
January 2016

Neurodevelopmental disease: A molecular tightrope.

Authors:
Ype Elgersma

Nature 2015 Oct;526(7571):50-1

Erasmus MC University Medical Center, ENCORE Expertise Center for Neurodevelopmental Disorders, Department of Neuroscience, 3015 CN Rotterdam, the Netherlands.

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http://dx.doi.org/10.1038/526050bDOI Listing
October 2015

In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome.

Front Cell Neurosci 2015 3;9:234. Epub 2015 Jul 3.

Department of Neuroscience, Erasmus MC, University Medical Center Rotterdam Rotterdam, Netherlands.

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http://dx.doi.org/10.3389/fncel.2015.00234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490249PMC
July 2015

Treatment of Cognitive Deficits in Genetic Disorders: A Systematic Review of Clinical Trials of Diet and Drug Treatments.

JAMA Neurol 2015 Sep;72(9):1052-60

Department of Neuroscience, Erasmus MC, University Medical Center, Rotterdam, the Netherlands3ENCORE-Expertise Center for Neurodevelopmental Disorders, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1001/jamaneurol.2015.0443DOI Listing
September 2015

Intact neuronal function in Rheb1 mutant mice: implications for TORC1-based treatments.

Hum Mol Genet 2015 Jun 10;24(12):3390-8. Epub 2015 Mar 10.

Department of Neuroscience and ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands

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http://dx.doi.org/10.1093/hmg/ddv087DOI Listing
June 2015

Conditional deletion of α-CaMKII impairs integration of adult-generated granule cells into dentate gyrus circuits and hippocampus-dependent learning.

J Neurosci 2014 Sep;34(36):11919-28

Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada, Institute of Medical Science, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada, Department of Psychology, University of Toronto, Toronto, Ontario M5S 3G3, Canada

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http://dx.doi.org/10.1523/JNEUROSCI.0652-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608460PMC
September 2014

Temporal and region-specific requirements of αCaMKII in spatial and contextual learning.

J Neurosci 2014 Aug;34(34):11180-7

Department of Neuroscience, and ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, 3015 GE, Rotterdam, The Netherlands, and

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http://dx.doi.org/10.1523/JNEUROSCI.0640-14.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340969PMC
August 2014

Mammalian target of rapamycin complex I (mTORC1) activity in ras homologue enriched in brain (Rheb)-deficient mouse embryonic fibroblasts.

PLoS One 2013 26;8(11):e81649. Epub 2013 Nov 26.

Molecular Cancer Research, Centre for Biomedical Genetics and Cancer Genomics Centre, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081649PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841147PMC
October 2014

Treatment of intractable epilepsy in tuberous sclerosis complex with everolimus is not yet evidence-based.

Ann Neurol 2014 Jan 2;75(1):163-4. Epub 2014 Jan 2.

Departments of Neurology, ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands; Neuroscience, ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.

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http://doi.wiley.com/10.1002/ana.24047
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http://dx.doi.org/10.1002/ana.24047DOI Listing
January 2014

Interaction of SH-SY5Y cells with nanogratings during neuronal differentiation: comparison with primary neurons.

Adv Healthc Mater 2014 Apr 1;3(4):581-7. Epub 2013 Oct 1.

NEST, Scuola Normale Superiore and Istituto Nanoscienze-CNR, Piazza San Silvestro 12, 56127, Pisa, Italy.

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http://dx.doi.org/10.1002/adhm.201300216DOI Listing
April 2014

Simvastatin for cognitive deficits and behavioural problems in patients with neurofibromatosis type 1 (NF1-SIMCODA): a randomised, placebo-controlled trial.

Lancet Neurol 2013 Nov 1;12(11):1076-83. Epub 2013 Oct 1.

Department of Neuroscience, Erasmus University Medical Centre, Rotterdam, Netherlands; Department of Paediatrics, Erasmus University Medical Centre, Rotterdam, Netherlands; ENCORE Expertise Centre For Neurodevelopmental Disorders, Erasmus University Medical Centre, Rotterdam, Netherlands.

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http://www.thelancet.com/pdfs/journals/laneur/PIIS1474-4422(
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http://linkinghub.elsevier.com/retrieve/pii/S147444221370227
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http://dx.doi.org/10.1016/S1474-4422(13)70227-8DOI Listing
November 2013

CaMKIIβ regulates oligodendrocyte maturation and CNS myelination.

J Neurosci 2013 Jun;33(25):10453-8

Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.5875-12.2013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685839PMC
June 2013

TORC1-dependent epilepsy caused by acute biallelic Tsc1 deletion in adult mice.

Ann Neurol 2013 Oct 10;74(4):569-79. Epub 2013 Sep 10.

Department of Neuroscience, Erasmus University Medical Center, Rotterdam, the Netherlands; ENCORE Expertise Center for Neurodevelopmental Disorders, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1002/ana.23943DOI Listing
October 2013

Rheb regulates mitophagy induced by mitochondrial energetic status.

Cell Metab 2013 May 18;17(5):719-30. Epub 2013 Apr 18.

EA4576, Maladies Rares: Génétique et Métabolisme, 33000 Bordeaux Cedex, France.

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http://dx.doi.org/10.1016/j.cmet.2013.03.014DOI Listing
May 2013

Treatment of neurodevelopmental disorders in adulthood.

J Neurosci 2012 Oct;32(41):14074-9

Neuroscience Center, University of Helsinki, 00014 Helsinki, Finland.

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http://dx.doi.org/10.1523/JNEUROSCI.3287-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500763PMC
October 2012

α-Calcium calmodulin kinase II modulates the temporal structure of hippocampal bursting patterns.

PLoS One 2012 20;7(2):e31649. Epub 2012 Feb 20.

Department of Neurobiology, Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031649PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3282754PMC
June 2012

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

J Neurosci 2011 Aug;31(35):12543-53

Department of Neuroscience, Erasmus MC, 3015 GE, Rotterdam, The Netherlands, Cancer Genomics Center, Department of Genetics, Center for Biomedical Genetics, Erasmus MC, 3015 GE, Rotterdam, The Netherlands.

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http://www.jneurosci.org/content/31/35/12543.full.pdf
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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.1589-11.2
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http://dx.doi.org/10.1523/JNEUROSCI.1589-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703271PMC
August 2011

Interval timing is intact in arrhythmic Cry1/Cry2-deficient mice.

J Biol Rhythms 2011 Aug;26(4):305-13

Department of Neuroscience, Erasmus University Medical Center, Rotterdam, the Netherlands.

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http://dx.doi.org/10.1177/0748730411410026DOI Listing
August 2011

Rheb: enrichment beyond the brain.

Cell Cycle 2011 Aug 1;10(15):2412-3. Epub 2011 Aug 1.

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http://dx.doi.org/10.4161/cc.10.15.16385DOI Listing
August 2011

Rheb is essential for murine development.

Mol Cell Biol 2011 Apr 14;31(8):1672-8. Epub 2011 Feb 14.

Department of Neuroscience, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.

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http://dx.doi.org/10.1128/MCB.00985-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3126339PMC
April 2011

Motor learning in children with neurofibromatosis type I.

Cerebellum 2011 Mar;10(1):14-21

Department of General Pediatrics, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1007/s12311-010-0217-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038237PMC
March 2011

betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses.

Nat Neurosci 2009 Jul 7;12(7):823-5. Epub 2009 Jun 7.

Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/nn.2329DOI Listing
July 2009

Neurofibromin regulation of ERK signaling modulates GABA release and learning.

Cell 2008 Oct;135(3):549-60

Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/j.cell.2008.09.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673196PMC
October 2008

Health-related quality of life in children with neurofibromatosis type 1: contribution of demographic factors, disease-related factors, and behavior.

J Pediatr 2009 Mar 31;154(3):420-5, 425.e1. Epub 2008 Oct 31.

NF1 CoRe Team (Cognitive Research Team), Department of General Pediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jpeds.2008.08.045DOI Listing
March 2009

Impact of neurofibromatosis type 1 on school performance.

J Child Neurol 2008 Sep;23(9):1002-10

Department of General Pediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1177/0883073808316366DOI Listing
September 2008

Oncogenes on my mind: ERK and MTOR signaling in cognitive diseases.

Trends Genet 2008 Oct 4;24(10):498-510. Epub 2008 Sep 4.

Department of Neuroscience, Erasmus University Medical Center, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.tig.2008.07.005DOI Listing
October 2008

Cognitive deficits in Tsc1+/- mice in the absence of cerebral lesions and seizures.

Ann Neurol 2007 Dec;62(6):648-55

Department of Neuroscience, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1002/ana.21317DOI Listing
December 2007

Kinase activity is not required for alphaCaMKII-dependent presynaptic plasticity at CA3-CA1 synapses.

Nat Neurosci 2007 Sep 29;10(9):1125-7. Epub 2007 Jul 29.

Department of Neuroscience, Erasmus University Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/nn1946DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804046PMC
September 2007

Rescue of neurological deficits in a mouse model for Angelman syndrome by reduction of alphaCaMKII inhibitory phosphorylation.

Nat Neurosci 2007 Mar 28;10(3):280-2. Epub 2007 Jan 28.

Erasmus MC, University Medical Centre, Department of Neuroscience, Dr. Molewaterplein 50, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/nn1845DOI Listing
March 2007

alphaCaMKII Is essential for cerebellar LTD and motor learning.

Neuron 2006 Sep;51(6):835-43

Department of Neuroscience, Erasmus MC, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.neuron.2006.08.013DOI Listing
September 2006

Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?

Nat Neurosci 2005 Oct 28;8(10):1292-4. Epub 2005 Aug 28.

Laboratoire de Physiologie de la Perception et de l'Action, UMR CNRS 7152, 11 place Marcelin Berthelot, Collège de France, 75005 Paris, France.

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http://dx.doi.org/10.1038/nn1532DOI Listing
October 2005

Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition.

J Neurosci 2004 Sep;24(39):8410-5

Department of Neuroscience, Erasmus Medical Center, 3000 DR, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1523/JNEUROSCI.3622-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6729904PMC
September 2004

Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.

Neuron 2002 Oct;36(3):493-505

Department of Neurobiology, Department of Psychiatry, Department of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1016/s0896-6273(02)01007-3DOI Listing
October 2002