Publications by authors named "Young-Kyu Han"

138 Publications

Cellular antioxidant potential and inhibition of foodborne pathogens by a sesquiterpene ilimaquinone in cold storaged ground chicken and under temperature-abuse condition.

Food Chem 2021 Oct 13;373(Pt A):131392. Epub 2021 Oct 13.

TERI-Deakin Nanobiotechnology Centre, The Energy and Resources Institute, Gwal Pahari, Gurugram, Haryana 122003, India. Electronic address:

A sesquiterpene quinone, ilimaquinone, was accessed for its cellular antioxidant efficacy and possible antimicrobial mechanism of action against foodborne pathogens (Staphylococcus aureus and Escherichia coli) in vitro and in vivo. Ilimaquinone was found to be protective against HO-induced oxidative stress as validated by the reduction in the ROS levels, including increasing expression of SOD1 and SOD2 enzymes. Furthermore, ilimaquinone evoked MIC against S. aureus and E. coli within the range of 125-250 µg/mL. Ilimaquinone established its antimicrobial mode of action against both tested pathogens as evident by bacterial membrane depolarization, loss of nuclear genetic material, potassium ion, and release of extracellular ATP, as well as compromised membrane permeabilization and cellular component damage. Also, ilimaquinone showed no teratogenic effect against zebrafish, suggesting its nontoxic nature. Moreover, ilimaquinone significantly reduced the S. aureus count without affecting the sensory properties and color values of cold-storaged ground chicken meat even under temperature abuse condition.
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http://dx.doi.org/10.1016/j.foodchem.2021.131392DOI Listing
October 2021

Nickel Cobaltite: A Positive Electrode Material for Hybrid Supercapacitors.

ChemSusChem 2021 Oct 12. Epub 2021 Oct 12.

Department of Physics, Sanjay Ghodawat University, Kolhapur, 416118, India.

The increased demand of energy due to the recent technological advances in diverse fields such as portable electronics and electric vehicles is often hindered by the poor capability of energy-storage systems. Although supercapacitors (SCs) exhibit higher power density than state-of-the art batteries, their insufficient energy density remains a major challenge. An emerging concept of hybrid supercapacitors (HSCs) with the combination of one capacitive and one battery electrode in a single cell holds a great promise to deliver high energy density without sacrificing power density and cycling stability. This Minireview elaborates the recent advances of use of nickel cobaltite (NiCo O ) as a potential positive electrode (battery-like) for HSCs. A brief introduction on the structural benefits and charge storage mechanisms of NiCo O was provided. It further shed a light on composites of NiCo O with different materials like carbon, polymers, metal oxides, and others, which altogether helps in increasing the electrochemical performance of HSCs. Finally, the key scientific challenges and perspectives on building high-performance HSCs for future-generation applications were reviewed.
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http://dx.doi.org/10.1002/cssc.202101465DOI Listing
October 2021

[email protected] metal-organic framework composite as an immunosensing platform for determination of hepatitis B virus surface antigen.

Mikrochim Acta 2021 10 6;188(11):365. Epub 2021 Oct 6.

TERI-Deakin Nanobiotechnology Centre, The Energy and Resources Institute, Gwal Pahari, Gurugram, Haryana, 122003, India.

An ultrasensitive electrochemical immunosensor has been prepared using an immunofunctionalized zirconium (Zr)-based metal-organic framework (MOF) with gold (Au) decoration [email protected](NH) composite-coated glassy carbon electrode (GCE) for the determination of infectious hepatitis B surface antigen (HBsAg). We fabricated GCE with specific composite via immune-functionalization using anti-HBsAg with Au nanoparticles embedded in UiO-66(NH). The electrochemical sensing performance of the immunofunctionalized [email protected](NH)/GCE with HBsAg was characterized by cyclic voltammetry and differential pulse voltammetry. Under optimized conditions, there was a linear dynamic relationship in the buffer system between the electrical signal and HBsAg levels over the range 1.13 fg mL-100 ng mL (R = 0.999) with a detection limit of 1.13 fg mL. The total analysis time was 15 min per sample. Further validations were performed with HBsAg-spiked human serum samples, and similar detection limits as in the buffer system were observed with reduced signal intensities at lower concentrations of HBsAg (1, 10, and 100 fg mL) and minimal interference. The HBsAg electrochemical immunosensing assay had good selectivity and excellent reproducibility, thereby indicating its significant potential in the super-fast diagnosis of hepatitis B.
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http://dx.doi.org/10.1007/s00604-021-05022-6DOI Listing
October 2021

Partners in crime: The Lewis Y antigen and fucosyltransferase IV in Helicobacter pylori-induced gastric cancer.

Pharmacol Ther 2021 Sep 24:107994. Epub 2021 Sep 24.

Department of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul 04620, Republic of Korea. Electronic address:

Helicobacter pylori (H. pylori) is a major causative agent of chronic gastritis, gastric ulcer and gastric carcinoma. H. pylori cytotoxin associated antigen A (CagA) plays a crucial role in the development of gastric cancer. Gastric cancer is associated with glycosylation alterations in glycoproteins and glycolipids on the cell surface. H. pylori cytotoxin associated antigen A (CagA) plays a significant role in the progression of gastric cancer through post-translation modification of fucosylation to develop gastric cancer. The involvement of a variety of sugar antigens in the progression and development of gastric cancer has been investigated, including type II blood group antigens. Lewis Y (LeY) is overexpressed on the tumor cell surface either as a glycoprotein or glycolipid. LeY is a difucosylated oligosaccharide, which is catalyzed by fucosyltransferases such as FUT4 (α1,3). FUT4/LeY overexpression may serve as potential correlative biomarkers for the prognosis of gastric cancer. We discuss the various aspects of H. pylori in relation to fucosyltransferases (FUT1-FUT9) and its fucosylated Lewis antigens (LeY, LeX, LeA, and LeB) and gastric cancer. In this review, we summarize the carcinogenic effect of H. pylori CagA in association with Le and its synthesis enzyme FUT4 in the development of gastric cancer as well as discuss its importance in the prognosis and its inhibition by combination therapy of anti-Le antibody and celecoxib through MAPK signaling pathway preventing gastric carcinogenesis.
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http://dx.doi.org/10.1016/j.pharmthera.2021.107994DOI Listing
September 2021

Hybridized 1D-2D MnMoO-MXene nanocomposites as high-performing electrochemical sensing platform for the sensitive detection of dihydroxybenzene isomers in wastewater samples.

J Hazard Mater 2022 01 31;421:126775. Epub 2021 Jul 31.

Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 100-715, Republic of Korea. Electronic address:

Hydroquinone (HQ) and catechol (CC) are the two major dihydroxybenzene isomers, are considered one of the toxic pollutants in wastewater, which often coexisted and impede each other during sample identification. For practical analysis and simultaneous detection of HQ and CC in wastewater, we fabricate a hybrid electrochemical sensor with electrospun one-dimensional (1D) MnMoO nanofibers coupled with a few-layered exfoliated two-dimensional (2D) MXene. The facilitated abundant defective edges of 1D MnMoO and 2D MXene nanoarchitecture accelerated the effect of synergistic signal amplification and exhibited high electrocatalytic activity towards the oxidation of hydroquinone and catechol. MnMoO-MXene-GCE showed oxidation potentials of 0.102 V and 0.203 V for hydroquinone and catechol, respectively. It revealed the distinguished and simultaneous detection range of 0.101 V with a strong anodic peak current. Noteworthily, the proposed 1D-2D hybridized MnMoO-MXene-GCE sensor exhibited a wide linear response from 5 nM to 65 nM for hydroquinone and catechol. Moreover, it showed a low detection limit of 0.26 nM and 0.30 nM for HQ and CC with high stability, respectively. The feasible 1D-2D MnMoO-MXene nanocomposite-based biosensor effectively detected hydroquinone and catechol in hazardous water pollutants using the differential pulse voltammetric technique with recovery values.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126775DOI Listing
January 2022

Highly efficient and robust noble-metal free bifunctional water electrolysis catalyst achieved via complementary charge transfer.

Nat Commun 2021 Jul 29;12(1):4606. Epub 2021 Jul 29.

Department of Materials Science and Engineering, Perovtronics Research Center, Low Dimensional Carbon Materials Center, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.

The operating principle of conventional water electrolysis using heterogenous catalysts has been primarily focused on the unidirectional charge transfer within the heterostructure. Herein, multidirectional charge transfer concept has been adopted within heterostructured catalysts to develop an efficient and robust bifunctional water electrolysis catalyst, which comprises perovskite oxides (LaSrCoO, LSC) and potassium ion-bonded MoSe (K-MoSe). The complementary charge transfer from LSC and K to MoSe endows MoSe with the electron-rich surface and increased electrical conductivity, which improves the hydrogen evolution reaction (HER) kinetics. Excellent oxygen evolution reaction (OER) kinetics of LSC/K-MoSe is also achieved, surpassing that of the noble metal (IrO), attributed to the enhanced adsorption capability of surface-based oxygen intermediates of the heterostructure. Consequently, the water electrolysis efficiency of LSC/K-MoSe exceeds the performance of the state-of-the-art Pt/C||IrO couple. Furthermore, LSC/K-MoSe exhibits remarkable chronopotentiometric stability over 2,500 h under a high current density of 100 mA cm.
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http://dx.doi.org/10.1038/s41467-021-24829-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322133PMC
July 2021

Insights into cyclooxygenase-2 inhibition by isolated bioactive compounds 3-caffeoyl-4-dihydrocaffeoyl quinic acid and isorhamnetin 3-O-β-D-glucopyranoside from Salicornia herbacea.

Phytomedicine 2021 Sep 29;90:153638. Epub 2021 Jun 29.

Department of Food Science and Technology, Yeungnam University, Gyeongsan, Gyeongsangbuk-do 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan, Gyeongsangbuk-do 38541, South Korea. Electronic address:

Background: Cyclooxygenase-2 (COX-2) is an important enzyme with numerous biological functions. Overexpression of COX-2 has been associated with various inflammatory-related diseases and therefore, projected as an important pharmacological target.

Purpose: We aimed to investigate the inhibitory potential of isolated bioactive compounds, 3-caffeoyl-4-dihydrocaffeoyl quinic acid (CDQ) and isorhamnetin 3-O-β-d-glucopyranoside (IDG), from Salicornia herbacea against COX-2 using both computational and in vitro approaches.

Methods: Computational analysis, including molecular docking, molecular dynamics (MD) simulations, and post-simulations analysis, were employed to estimate the binding affinity and stability of CDQ and IDG in the catalytic pocket of COX-2 against Celecoxib as positive control. These predictions were further evaluated using in vitro enzyme inhibition as well as gene expression mediation in macrophages cells.

Results: Molecular docking analysis revealed substantial binding energy of CDQ (-6.1 kcal/mol) and IDG (-5.9 kcal/mol) with COX-2, which are lower than Celecoxib (-8.1 kcal/mol). MD simulations (100 ns) and post simulation analysis exhibited the substantial stability and binding affinity of docked CDQ and IDG compounds with COX-2. In vitro assays indicated significant COX-2 inhibition by CDQ (IC = 76.91 ± 2.33 μM) and IDG (IC = 126.06 ± 9.44 μM). This result supported the inhibitory potential of isolated bioactive compounds against COX-2. Also, a cellular level study revealed a downregulation of COX-2 expression in tumor necrosis factor-alpha stimulated RAW 264.7 macrophages treated with CDQ and IDG.

Conclusion: Computational and experimental analysis of CDQ and IDG from S. herbacea established their potential in the inhibition and mediation of COX-2. Hence, CDQ and IDG can be considered for therapeutic development against COX-2 linked disorders, such as inflammation and cancer. Furthermore, CDQ and IDG structures can be served as a lead compound for the development of advanced novel anti-inflammatory drugs.
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http://dx.doi.org/10.1016/j.phymed.2021.153638DOI Listing
September 2021

Substitutional Vanadium Sulfide Nanodispersed in MoS Film for Pt-Scalable Catalyst.

Adv Sci (Weinh) 2021 Aug 3;8(16):e2003709. Epub 2021 Jun 3.

Department of Energy Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Among transition metal dichalcogenides (TMdCs) as alternatives for Pt-based catalysts, metallic-TMdCs catalysts have highly reactive basal-plane but are unstable. Meanwhile, chemically stable semiconducting-TMdCs show limiting catalytic activity due to their inactive basal-plane. Here, metallic vanadium sulfide (VS ) nanodispersed in a semiconducting MoS film (V-MoS ) is proposed as an efficient catalyst. During synthesis, vanadium atoms are substituted into hexagonal monolayer MoS to form randomly distributed VS units. The V-MoS film on a Cu electrode exhibits Pt-scalable catalytic performance; current density of 1000 mA cm at 0.6 V and overpotential of -0.08 V at a current density of 10 mA cm with excellent cycle stability for hydrogen-evolution-reaction (HER). The high intrinsic HER performance of V-MoS is explained by the efficient electron transfer from the Cu electrode to chalcogen vacancies near vanadium sites with optimal Gibbs free energy (-0.02 eV). This study provides insight into ways to engineer TMdCs at the atomic-level to boost intrinsic catalytic activity for hydrogen evolution.
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http://dx.doi.org/10.1002/advs.202003709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373103PMC
August 2021

Deep Learning-Assisted Quantification of Atomic Dopants and Defects in 2D Materials.

Adv Sci (Weinh) 2021 Aug 3;8(16):e2101099. Epub 2021 Jun 3.

Department of Energy Science, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

Atomic dopants and defects play a crucial role in creating new functionalities in 2D transition metal dichalcogenides (2D TMDs). Therefore, atomic-scale identification and their quantification warrant precise engineering that widens their application to many fields, ranging from development of optoelectronic devices to magnetic semiconductors. Scanning transmission electron microscopy with a sub-Å probe has provided a facile way to observe local dopants and defects in 2D TMDs. However, manual data analytics of experimental images is a time-consuming task, and often requires subjective decisions to interpret observed signals. Therefore, an approach is required to automate the detection and classification of dopants and defects. In this study, based on a deep learning algorithm, fully convolutional neural network that shows a superior ability of image segmentation, an efficient and automated method for reliable quantification of dopants and defects in TMDs is proposed with single-atom precision. The approach demonstrates that atomic dopants and defects are precisely mapped with a detection limit of ≈1 × 10 cm , and with a measurement accuracy of ≈98% for most atomic sites. Furthermore, this methodology is applicable to large volume of image data to extract atomic site-specific information, thus providing insights into the formation mechanisms of various defects under stimuli.
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http://dx.doi.org/10.1002/advs.202101099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373156PMC
August 2021

Epitaxial Single-Crystal Growth of Transition Metal Dichalcogenide Monolayers via the Atomic Sawtooth Au Surface.

Adv Mater 2021 Apr 10;33(15):e2006601. Epub 2021 Mar 10.

Center for Integrated Nanostructure Physics (CINAP), Institute for Basic Science (IBS), Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Growth of 2D van der Waals layered single-crystal (SC) films is highly desired not only to manifest the intrinsic physical and chemical properties of materials, but also to enable the development of unprecedented devices for industrial applications. While wafer-scale SC hexagonal boron nitride film has been successfully grown, an ideal growth platform for diatomic transition metal dichalcogenide (TMdC) films has not been established to date. Here, the SC growth of TMdC monolayers on a centimeter scale via the atomic sawtooth gold surface as a universal growth template is reported. The atomic tooth-gullet surface is constructed by the one-step solidification of liquid gold, evidenced by transmission electron microscopy. The anisotropic adsorption energy of the TMdC cluster, confirmed by density-functional calculations, prevails at the periodic atomic-step edge to yield unidirectional epitaxial growth of triangular TMdC grains, eventually forming the SC film, regardless of the Miller indices. Growth using the atomic sawtooth gold surface as a universal growth template is demonstrated for several TMdC monolayer films, including WS , WSe , MoS , the MoSe /WSe heterostructure, and W Mo S alloys. This strategy provides a general avenue for the SC growth of diatomic van der Waals heterostructures on a wafer scale, to further facilitate the applications of TMdCs in post-silicon technology.
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http://dx.doi.org/10.1002/adma.202006601DOI Listing
April 2021

Reproductive toxic potential of phthalate compounds - State of art review.

Pharmacol Res 2021 05 4;167:105536. Epub 2021 Mar 4.

Department of Energy and Materials Engineering, Dongguk University, 30 Pildong-ro 1-gil, Seoul 04620, South Korea. Electronic address:

Phthalates are pervasive compounds, and due to the ubiquitous usage of phthalates, humans or even children are widely exposed to them. Since phthalates are not chemically bound to the plastic matrix, they can easily leach out to contaminate the peripheral environment. Various animal and human studies have raised vital health concern including developmental and reproductive toxicity of phthalate exposure. The present review is based upon the available literature on phthalates with respect to their reproductive toxic potential. Common reproductive effects such as declined fertility, reduced testis weight, variations in accessory sex organs and several female reproductive disorders appeared to be largely associated with the transitional phthalates. Among the higher molecular weight phthalates (≥ C7), di-isononyl phthalate (DINP) produces some minor effects on development of male reproductive tract and among low molecular weight phthalates (≤C3), di-methyl (DMP) and di-isobutyl (DIBP) phthalate produce some adverse effects on male reproductive system. Whereas transitional phthalates such as di-butyl phthalate, benzyl butyl phthalate, and di-(2-ethylhexyl) phthalate have shown adverse effects on female reproductive system. Owing to these, non-toxic alternatives to phthalates may be developed and use of phthalates could be rationalized as an important issue where human reproduction system is involved. Though, more epidemiological studies are needed to substantiate the reported findings on phthalates.
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http://dx.doi.org/10.1016/j.phrs.2021.105536DOI Listing
May 2021

A facile method for the fabrication of hierarchically structured NiCoS nanopetals on carbon nanofibers to enhance non-enzymatic glucose oxidation.

Mikrochim Acta 2021 03 2;188(3):106. Epub 2021 Mar 2.

Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 100-715, Republic of Korea.

Unique NiCoS-carbon nanofiber (CNF) composite nanostructures were fabricated using a simple electrospinning-assisted hydrothermal route and used for the rapid and accurate electrochemical oxidation of glucose in real samples at the trace level. Electrochemical impedance spectroscopy and cyclic voltammetry of unmodified and modified electrodes revealed low charge-transfer resistance and the excellent electrocatalytic sensing of glucose when using the NiCoS-CNF at a low potential due to the combined benefits of the highly conductive NiCoS anchored to the large surface area of the CNFs. Amperometric analysis of the fabricated sensor has shown an extremely low limit of detection (0.25 nM) and a large linear range (5-70 nM) for glucose at a working potential of 0.54 V (vs. Hg/HgO). The practicability of the NiCoS-CNF for use in glucose determination was tested withl human saliva, blood plasma, and fruit juice samples. The NiCoS-CNF/GCE showed acceptable recovery values for human saliva (99.1-100.8%), blood plasma (98.6-101.5%), and fruit juice (95.1-105.7%) samples. The proposed sensor also exhibited outstanding electroanalytical characteristics for glucose oxidation in these samples, including reusability, repeatability, and interference resistance, even in the presence of other biological substances and organic and inorganic metal ions.
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http://dx.doi.org/10.1007/s00604-021-04749-6DOI Listing
March 2021

Bottom-up Approach for Designing Cobalt Tungstate Nanospheres through Sulfur Amendment for High-Performance Hybrid Supercapacitors.

ChemSusChem 2021 Mar 17;14(6):1602-1611. Epub 2021 Feb 17.

MEMS and Nanotechnology Laboratory, School of Mechanical Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea.

Nanofabrication of heteroatom-doped metal oxides into a well-defined architecture via a "bottom-up" approach is crucial to overcome the boundaries of the metal oxides for energy storage systems. In the present work, this issue was addressed by developing sulfur-doped bimetallic cobalt tungstate (CoWO ) porous nanospheres for efficient hybrid supercapacitors via a single-step, ascendable bottom-up approach. The combined experimental and kinetics studies revealed enhanced electrical conductivity, porosity, and openness for ion migration after amendments of the CoWO via sulfur doping. As a result, the sulfur-doped CoWO nanospheres exhibited a specific capacity of 248.5 mA h g with outstanding rate capability and cycling stability. The assembled hybrid supercapacitor cell with sulfur-doped CoWO nanospheres and activated carbon electrodes could be driven reversibly in a voltage of 1.6 V and exhibited a specific capacitance of 177.25 F g calculated at 1.33 A g with a specific energy of 63.41 Wh kg at 1000 W kg specific power. In addition, the hybrid supercapacitor delivered 94.85 % initial capacitance over 10000 charge-discharge cycles. The excellent supercapacitive performance of sulfur-doped CoWO nanospheres may be credited to the sulfur doping and bottom-up fabrication of the electrode materials.
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http://dx.doi.org/10.1002/cssc.202002968DOI Listing
March 2021

Simple synthesis of a clew-like tungsten carbide nanocomposite decorated with gold nanoparticles for the ultrasensitive detection of tert-butylhydroquinone.

Food Chem 2021 Jun 24;348:128936. Epub 2020 Dec 24.

Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 100-715, Republic of Korea. Electronic address:

The excessive use of food additives in manufactured food products negatively affects their quality and potentially impacts human health. In the present study, a composite consisting of gold nanoparticles decorated on tungsten carbide (AuNP-WC) was successfully fabricated using a facile and cost-effective ultrasonication technique. Compared to a bare glassy carbon electrode (GCE), AuNP-GCE, and WC-GCE, the AuNP-WC-GCE demonstrated excellent sensing performance for tert-butylhydroquinone (TBHQ) when used as an electrocatalyst in 0.05 M phosphate buffer solution (PBS), with a low working potential and a high peak current. In particular, the composite was able to detect the oxidation of TBHQ within a linear concentration range of 5 to 75 nM, with an extremely low detection limit of 0.20 nM. The practicability of the sensor was also assessed in the analysis of TBHQ in real samples of soybean oil, blended oil, and red wine, with satisfactory recovery rates obtained.
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http://dx.doi.org/10.1016/j.foodchem.2020.128936DOI Listing
June 2021

Metasequoia glyptostroboides potentiates anticancer effect against cervical cancer via intrinsic apoptosis pathway.

Sci Rep 2021 01 13;11(1):894. Epub 2021 Jan 13.

Department of Biological Engineering, NanoBio High-Tech Materials Research Center, Inha University, 100 Inha-ro, Nam-gu, Incheon, 22212, Republic of Korea.

This study was undertaken to investigate the anticancer effects of organic extracts derived from the floral cones of Metasequoia glyptostroboides. Dried powder of M. glyptostroboides floral cones was subjected to methanol extraction, and the resulting extract was further partitioned by liquid-liquid extraction using the organic solvents n-hexane, dichloromethane (DME), chloroform, and ethyl acetate in addition to deionized water. HeLa cervical and COS-7 cells were used as a cancer cell model and normal cell control, respectively. The anticancer effect was evaluated by using the Cell Counting Kit-8 assay. The viability of COS-7 cells was found to be 12-fold higher than that of the HeLa cells under the administration of 50 µg/ml of the DME extract. Further, the sub-G1 population was determined by FACS analysis. The number of cells at the sub-G1 phase, which indicates apoptotic cells, was increased approximately fourfold upon treatment with the DME and CE extracts compared with that in the negative control. Furthermore, RT-qPCR and western blotting were used to quantitate the relative RNA and protein levels of the cell death pathway components, respectively. Our results suggest that the extracts of M. glyptostroboides floral cones, especially the DME extract, which possesses several anticancer components, as determined by GC-MS analysis, could a potential natural anticancer agent.
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http://dx.doi.org/10.1038/s41598-020-79573-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7806586PMC
January 2021

Pd-Cu nanospheres supported on MoC for the electrochemical sensing of nitrites.

J Hazard Mater 2021 04 20;408:124914. Epub 2020 Dec 20.

Department of Energy and Materials Engineering, Dongguk University, Seoul 100-715, Republic of Korea. Electronic address:

The improper disposal in agricultural and industrial wastewater leads to high NO concentrations in the aquatic environment, which can cause cancer in humans and animals; thus, their quick and accurate detection is urgently needed to ensure public health and environmental safety. In this study, a reliable and selective electrochemical sensor consisting of Pd-Cu nanospheres (NSs) supported on molybdenum carbide was prepared via simple ultrasonication. Then, a glassy carbon electrode was realized using this composite (Pd-Cu-MoC-modified GCE) to test its electrocatalytic sensing for NO in a 0.1 M phosphate-buffered solution (PBS) solution via cyclic voltammetry and amperometry; at a low oxidation potential, the anodic peak current of NO detected by this electrode was significantly higher than that of its unmodified and other modified electrodes. The sensor showed a broad linear response in the 5-165-nM NO concentration range, with a low detection limit (0.35 nM in 0.1 M PBS) and high sensitivity (3.308 μAnM cm). Moreover, the fabricated electrode was successfully applied for detecting nitrites in sausages, river water, and milk, showing also good recovery.
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http://dx.doi.org/10.1016/j.jhazmat.2020.124914DOI Listing
April 2021

Silicon as the Anode Material for Multivalent-Ion Batteries: A First-Principles Dynamics Study.

ACS Appl Mater Interfaces 2020 Dec 2;12(50):55746-55755. Epub 2020 Dec 2.

Department of Energy and Materials Engineering and Advanced Energy and Electronic Materials Research Center, Dongguk University-Seoul, Seoul 04620, Republic of Korea.

Due to its huge capacity, Si is a promising anode material for practical applications in lithium-ion batteries. Here, using first-principles calculations, we study the applicability of the amorphous Si anode in multivalent-ion batteries, which are of great interest as candidates for post-lithium-ion batteries. Of the multivalent Mg, Ca, Zn, and Al ions, only Mg and Ca are able to form MgSi and CaSi by alloying with Si, delivering very high capacities of 4390 and 4771 mA h g, respectively. MgSi has an 8% smaller capacity than CaSi, but its volume expansion ratio and ion diffusivity are ∼200% smaller and 3 orders of magnitude higher than those of CaSi, respectively. The capacity, volume expansion, and ion diffusion of MgSi are excellently high, moderately small, and fairly fast, respectively, when compared to those of LiSi, NaSi, and KSi. The high performance of MgSi can be understood in terms of the coordination numbers of Si and the atomic size of Mg. This work suggests that, as a carrier ion for the amorphous Si anode, Mg is the most competitive among the multivalent ions and is at least as good as monovalent ions.
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http://dx.doi.org/10.1021/acsami.0c13312DOI Listing
December 2020

Sugiol, a diterpenoid: Therapeutic actions and molecular pathways involved.

Pharmacol Res 2021 01 24;163:105313. Epub 2020 Nov 24.

Department of Energy and Materials Engineering, Dongguk University, 30 Pildong-ro 1-gil, Seoul, 04620, South Korea. Electronic address:

Understanding how the natural products structural diversity interacts with cellular metabolism and infectious disease targets remains a challenge. Inflammation is an important process in the human healing response in which the tissues respond to injuries induced by many agents, including pathogens. In recent years, several drugs derived from plant products have been developed, and current drug research is actively investigating the pharmacotherapeutic role of natural products in advanced multimodal inflammatory disease targeting. Sugiol, a diterpenoid, can act as an antimicrobial, antioxidant, anti-inflammatory, anti-carcinoma, antiviral, and cardiovascular agent. Until now, there have been no updates on the pharmacotherapeutic advancement of sugiol. Herein, we correlate the diverse molecular pathways in disease prevention involving sugiol. We also discuss the origins of its structural diversity and summarize new research directions toward exploring its novel effective future uses. Despite much evidence of its efficacy and safety, the sugiol has not yet been approved as a therapeutic agent due to its low bioavailability, and insolubility in an aqueous environment. The aim of this review is to renew and update noteworthy information on the pharmacotherapeutic characteristics of sugiol to approach different advanced strategies employed in the context of natural nurturing-based biomedicine.
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http://dx.doi.org/10.1016/j.phrs.2020.105313DOI Listing
January 2021

Why Does Dimethyl Carbonate Dissociate Li Salt Better Than Other Linear Carbonates? Critical Role of Polar Conformers.

J Phys Chem Lett 2020 Dec 25;11(24):10382-10387. Epub 2020 Nov 25.

Department of Energy Science and Engineering, DGIST, Daegu 42988, Republic of Korea.

The marked difference in the ionic conductivities of linear carbonate (LC) electrolyte solutions despite their similar viscosities and permittivities is a long-standing puzzle. This study unraveled the critical impact of solvent conformational isomerism on salt dissociation in 0.1-3.0 M LiPF dimethyl carbonate (DMC), ethyl methyl carbonate (EMC), and diethyl carbonate (DEC) solutions using Raman and dielectric relaxation spectroscopies. The extent of salt dissociation in the LC solutions, which decreased in the order DMC > EMC > DEC, is closely related to the fraction of polar LC conformers, as this conformer participates in Li ion solvation more readily than the nonpolar counterpart. Our first-principles calculations corroborated that the conformer facilitates free ion formation more than the conformer, and the extent of this effect decreased in the order DMC > EMC > DEC. This study provides an avenue for the design of highly conductive electrolytes by exploiting the conformational isomerism of solvent molecules.
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http://dx.doi.org/10.1021/acs.jpclett.0c03235DOI Listing
December 2020

Morin Hydrate Sensitizes Hepatoma Cells and Xenograft Tumor towards Cisplatin by Downregulating PARP-1-HMGB1 Mediated Autophagy.

Int J Mol Sci 2020 Nov 4;21(21). Epub 2020 Nov 4.

Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk 38453, Korea.

The cross-talk between apoptosis and autophagy influences anticancer drug sensitivity and cellular death in various cancer cell lines. However, the fundamental mechanisms behind this phenomenon are still unidentified. We demonstrated anti-cancerous role of cisplatin (CP) and morin hydrate (Mh) as an individual and/or in combination (CP-Mh) in hepatoma cells and tumor model. Exposure of CP resulted in the production of intracellular reactive oxygen species (ROS)-mediated cellular vacuolization, expansion of mitochondria membrane and activation of endoplasmic reticulum (ER)-stress. Consequently, Cyt translocation led to the increase of Bax/Bcl-2 ratio, which simultaneously triggered caspase-mediated cellular apoptosis. In addition, CP-induced PARP-1 activation led to ADP-ribosylation of HMGB1, which consequently developed autophagy as evident by the LC3I/II ratio. Chemically-induced inhibition of autophagy marked by increased cell death signified a protective role of autophagy against CP treatment. CP-Mh abrogates the PARP-1 expression and significantly reduced HMGB1-cytoplasmic translocation with subsequent inhibition of the HMGB1-Beclin1 complex formation. In the absence of PARP-1, a reduced HMGB1 mediated autophagy was observed followed by induced caspase-dependent apoptosis. To confirm the role of PARP-1-HMGB1 signaling in autophagy, we used the PARP-1 inhibitor, 4-amino-1,8-naphthalimide (ANI), HMGB1 inhibitor, ethyl pyruvate (EP), autophagy inhibitors, 3-methyl adenine (3-MA) and bafilomycin (baf) and small interfering RNAs (siRNA) to target Atg5 in combination of CP and Mh. Exposure to these inhibitors enhanced the sensitivity of HepG2 cells to CP. Collectively, our findings indicate that CP-Mh in combination served as a prominent regulator of autophagy and significant inducer of apoptosis that maintains a homeostatic balance towards HepG2 cells and the subcutaneous tumor model.
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http://dx.doi.org/10.3390/ijms21218253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885522PMC
November 2020

(-)-Tetrahydroberberrubine∙acetate accelerates antioxidant potential and inhibits food associated Bacillus cereus in rice.

Food Chem 2021 Mar 26;339:127902. Epub 2020 Aug 26.

Department of Food Science and Technology, National Institute of Food Technology Entrepreneurship and Management (NIFTEM), Sonipat, Haryana 131028, India. Electronic address:

A protoberberine alkaloid, (-)-tetrahydroberberrubine∙acetate (THBA) was assessed for its antioxidant potential and ability to inhibit the growth of a food hazard bacterium Bacillus cereus in vitro and in situ. THBA displayed significant and dose-dependent cellular antioxidant potential against hydrogen peroxide-induced oxidative stress in NIH 3T3 fibroblast cells and decreased the ROS levels as well as increased the expression levels of SOD1 and SOD2 enzymes. The inhibitory spectrum of THBA confirmed its mechanistic role in the disruption of the membrane integrity of B. cereus as evidenced by the results of time-inactivation, cell membrane integrity, NPN membrane uptake, membrane potential, and electron microscopy analyses. Moreover, THBA inhibited biofilm formation by B. cereus and disrupted pre-established biofilms on a glass surface. Furthermore, THBA was also able to inhibit B. cereus in raw rice with a significant amount of reduction in CFU counts, suggesting its potential role as a natural antioxidant and antimicrobial agent.
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http://dx.doi.org/10.1016/j.foodchem.2020.127902DOI Listing
March 2021

Folic acid-modified bovine serum albumin nanoparticles with doxorubicin and chlorin e6 for effective combinational chemo-photodynamic therapy.

Mater Sci Eng C Mater Biol Appl 2020 Dec 11;117:111343. Epub 2020 Aug 11.

Department of Biological Engineering, NanoBio High-Tech Materials Research Center, Inha University, Incheon 22212, Republic of Korea. Electronic address:

We herein describe a facile method to synthesize stable bovine serum albumin-based nanoparticles (BNPs) loaded with two anticancer therapeutics, doxorubicin (DOX) and a photosensitizer, chlorin e6 (Ce6), in combination with folic acid (FA) as a target cancer cell receptor for the development of an effective combined chemo and photodynamic (FA-Ce6/DOX/BNPs) therapy against cervical cancer. FA-Ce6/DOX/BNPs exhibited excellent monodispersity with an average diameter of 103.5 ± 3.8 nm, a negative zeta potential of approximately -30.44 ± 0.35 mV, and long-term stability. As a result, FA-Ce6/DOX/BNPs exhibited severe toxicity to cervical HeLa cancer cells. Also, a higher drug release rate was observed under acidic pH conditions (pH 5.0). Moreover, FA-Ce6/DOX/BNPs potentiated mitochondrial reactive oxygen species (ROS) production in HeLa cells under 671-nm laser exposure, leading to activation of key regulator proteins of apoptosis such as BH3 interacting-domain death agonist (BID), B-cell lymphoma 2 (Bcl-2), and Bcl-2-associated X (BAX), as well as induction of the caspase cascade and mitochondrial ROS-mediated cell death. Confocal microscopy analysis further validated cellular uptake of FA-Ce6/DOX/BNPs by HeLa cells. Furthermore, results of real-time quantitative PCR (RT-qPCR) and western blot analysis further validated the anticancer effect of FA-Ce6/DOX/BNPs, as evidenced by elevated gene/protein expression levels of apoptotic biomarkers p53, BID, caspase-3, cleaved poly(ADP-ribose) polymerase 1 (PARP-1), and BAX, contrary to levels of the anti-apoptotic marker Bcl-2. Moreover, in vivo toxicity results of FA-Ce6/DOX/BNPs using laser irradiation in zebrafish larvae, as a chemo-photodynamic therapy confirmed that it does not affect the larval development without causing any adverse toxic effect in zebrafish larvae. Altogether these findings strongly support the anticancer effect of FA-Ce6/DOX/BNPs combinational chemo-photodynamic therapy, which could be a promising candidate for cervical cancer therapy.
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http://dx.doi.org/10.1016/j.msec.2020.111343DOI Listing
December 2020

True Meaning of Pseudocapacitors and Their Performance Metrics: Asymmetric versus Hybrid Supercapacitors.

Small 2020 Sep 6;16(37):e2002806. Epub 2020 Aug 6.

Centre for Materials Science, Queensland University of Technology (QUT), 2 George Street, Brisbane, QLD, 4001, Australia.

The development of pseudocapacitive materials for energy-oriented applications has stimulated considerable interest in recent years due to their high energy-storing capacity with high power outputs. Nevertheless, the utilization of nanosized active materials in batteries leads to fast redox kinetics due to the improved surface area and short diffusion pathways, which shifts their electrochemical signatures from battery-like to the pseudocapacitive-like behavior. As a result, it becomes challenging to distinguish "pseudocapacitive" and "battery" materials. Such misconceptions have further impacted on the final device configurations. This Review is an earnest effort to clarify the confusion between the battery and pseudocapacitive materials by providing their true meanings and correct performance metrics. A method to distinguish battery-type and pseudocapacitive materials using the electrochemical signatures and quantitative kinetics analysis is outlined. Taking solid-state supercapacitors (SSCs, only polymer gel electrolytes) as an example, the distinction between asymmetric and hybrid supercapacitors is discussed. The state-of-the-art progress in the engineering of active materials is summarized, which will guide for the development of real-pseudocapacitive energy storage systems.
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http://dx.doi.org/10.1002/smll.202002806DOI Listing
September 2020

Multifunctional N-P-doped carbon dots for regulation of apoptosis and autophagy in B16F10 melanoma cancer cells and imaging applications.

Theranostics 2020 22;10(17):7841-7856. Epub 2020 Jun 22.

Department of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul 04620, Republic of Korea.

The present study reports the multifunctional anticancer activity against B16F10 melanoma cancer cells and the bioimaging ability of fluorescent nitrogen-phosphorous-doped carbon dots (NPCDs). The NPCDs were synthesized using a single-step, thermal treatment and were characterized by TEM, XPS, fluorescence and UV-Vis spectroscopy, and FTIR analysis. The anticancer efficacy of NPCDs was confirmed by using cell viability assay, morphological evaluation, fluorescent live-dead cell assay, mitochondrial potential assay, ROS production, RT-PCR, western-blot analysis, siRNA transfection, and cellular bioimaging ability. The NPCDs inhibited the proliferation of B16F10 melanoma cancer cells after 24 h of treatment and induced apoptosis, as confirmed by the presence of fragmented nuclei, reduced mitochondrial membrane potential, and elevated levels of reactive oxygen species. The NPCDs treatment further elevated the levels of pro-apoptotic factors and down-regulated the level of Bcl2 (B-cell lymphoma 2) that weakened the mitochondrial membrane, and activated proteases such as caspases. Treatment with NPCDs also resulted in dose-dependent cell cycle arrest, as indicated by reduced cyclin-dependent kinase (CDK)-2, -4, and -6 protein levels and an enhanced level of p21. More importantly, the NPCDs induced the activation of autophagy by upregulating the protein expression levels of LC3-II and ATG-5 (autophagy-related-5) and by downregulating p62 level, validated by knockdown of ATG-5. Additionally, owing to their excellent luminescence property, these NPCDs were also applicable in cellular bioimaging, as evidenced by the microscopic fluorescence imaging of B16F10 melanoma cells. Based on these findings, we conclude that our newly synthesized NPCDs induced cell cycle arrest, autophagy, and apoptosis in B16F10 melanoma cells and presented good cellular bioimaging capability.
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http://dx.doi.org/10.7150/thno.42291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7359102PMC
May 2021

A radially controlled ZnS interlayer on ultra-long ZnO-GdS core-shell nanorod arrays for promoting the visible photocatalytic degradation of antibiotics.

Nanoscale 2020 Jul 25;12(26):14047-14060. Epub 2020 Jun 25.

Department of Energy and Material Engineering, Dongguk University, Seoul 04620, Republic of Korea.

Nanorod (NR) arrays offer commendable visible-light-driven photocatalytic performances. Herein, we describe the construction of a ternary ZnO-ZnS-GdS nanostructural array in which a sulfidation process is used to decorate a GdS shell layer with a ZnS interface over vapor-phase-grown vertically-aligned ZnO. With control over the shell-wall thickness, the shell layer of ∼25 nm wall thickness on the ultra-long ZnO NR arrays exhibited a higher catalytic efficiency close to 3.3, 2.0, 1.2, and 1.8 times those of the bare ZnO, the ZnO-ZnS, the GdS-decorated (∼10 nm) and GdS shell-layered (∼40 nm) ZnO-ZnS core-shell structures, respectively. The core-shell geometry and the shell-wall thickness with maximized contact interface afforded increased light absorption in the visible region and effectively retarded the recombination rate of the photoinduced charge carriers by confining electrons and holes separately, thus providing advantages in terms of the degradation of the pharmaceutical residue tetracycline and the industrial pollutant 4-nitrophenol in wastewater.
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http://dx.doi.org/10.1039/d0nr03094eDOI Listing
July 2020

Improved conductivity of flower-like MnWO on defect engineered graphitic carbon nitride as an efficient electrocatalyst for ultrasensitive sensing of chloramphenicol.

J Hazard Mater 2020 11 19;399:122868. Epub 2020 May 19.

Department of Energy and Materials Engineering, Dongguk University, Seoul 100-715, Republic of Korea. Electronic address:

Environmental hazards caused by chloramphenicol has attained special attention. Fast, accurate and reliable detection of chloramphenicol in foodstuffs and water samples is of utmost importance. Herein, we developed a g-CN/MnWO composite for the selective and sensitive detection of chloramphenicol. Successful fabrication of g-CN/MnWO composite was verified by using scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD) and x-ray photo electron spectroscopy (XPS) techniques. Electrochemical characteristics were evaluated by using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The g-CN/MnWO modified glassy carbon electrode has shown the highest electrocatalytic activity towards chloramphenicol with a decreased reduction potential of -0.547 V and increased cathodic peak current. The developed sensor has shown excellent performance for the detection of chloramphenicol with a sensitivity of 0.9986 μA nM cm and LOD of 1.03 nM in a broad linear range of 4.0-71 nM. In addition, the fabricated sensor has achieved anti-interference ability, good stability, excellent repeatability and remarkable reproducibility for the detection of chloramphenicol. The fabricated sensor applied for the determination of chloramphenicol in milk, human blood serum and sewage samples, in which significant and satisfactory results were achieved.
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http://dx.doi.org/10.1016/j.jhazmat.2020.122868DOI Listing
November 2020

One-Dimensional NiSe-Se Hollow Nanotubular Architecture as a Binder-Free Cathode with Enhanced Redox Reactions for High-Performance Hybrid Supercapacitors.

ACS Appl Mater Interfaces 2020 Jul 22;12(26):29302-29315. Epub 2020 Jun 22.

School of Nano Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.

Selenium-enriched nickel selenide (NiSe-Se) nanotubes supported on highly conductive nickel foam ([email protected] foam) were synthesized using chemical bath deposition with the aid of lithium chloride as a shape-directing agent. The uniformly grown [email protected] foam, with its large number of electroactive sites, facilitated rapid diffusion and charge transport. The [email protected] foam electrode exhibited a superior specific capacitance value of 2447.46 F g at a current density value of 1 A g in 1 M aqueous KOH electrolyte. Furthermore, a high-energy-density pouch-type hybrid supercapacitor (HSC) device was fabricated using the proposed [email protected] foam as the positive electrode, activated carbon on Ni foam as the negative electrode, and a filter paper separator soaked in 1 M KOH electrolyte solution. The HSC delivered a specific capacitance of 84.10 F g at a current density of 4 mA cm with an energy density of 29.90 W h kg at a power density of 594.46 W kg for an extended operating voltage window of 1.6 V. In addition, the HSC exhibited excellent cycling stability with a capacitance retention of 95.09% after 10,000 cycles, highlighting its excellent potential for use in the hands-on applications. The real-life practicality of the HSC was tested by using it to power a red light-emitting diode.
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http://dx.doi.org/10.1021/acsami.0c05612DOI Listing
July 2020

N,P-Doped Carbon Nanodots for Food-Matrix Decontamination, Anticancer Potential, and Cellular Bio-Imaging Applications.

J Biomed Nanotechnol 2020 Mar;16(3):283-303

We report a facile one-step thermal treatment method for the synthesis of biocompatible, fluorescent nitrogen-phosphorus-doped carbon nanodots (NPCDs) as multifunctional agents for the food matrix decontamination, cancer targeting, and cellular bio-imaging. NPCDs exhibit high toxicity towards , as illustrated by fluorescent live-dead cell counting, disruption of membrane permeability/potential, changes in the levels of cellular ions, genetic materials, and proteins, as well as intracellular production of reactive oxygen species. The tryptophan and protein peaks released in NPCDs treated cells contributed to indole ring breathing and correlated with induced cell death. NPCDs significantly inhibited bacterial biofilm formation on a solid substrate. NPCDs-coated low-density polyethylene (LDPE) film crosslinked with 1% aminopropyltriethoxy silane (APTES) via silane-hydroxyl linking as a food-grade wrap significantly reduced bacterial counts in a raw chicken food model. Furthermore, NPCDs induced apoptosis in HeLa cervical cancer cells, as confirmed by the distorted cell morphology, fluorescence microscopic analysis, presence of fragmented nuclei and the qPCR results of mRNA expression levels of apoptotic markers. Moreover, NPCDs were also applicable in utilized for the cellular bio-imaging of KM12-C colon cancer cells under confocal microscopy owing to their excellent luminescence properties. Overall, NPCDs represent a promising platform to reduce the environmental health risks associated with hazardous pathogens, anticancer targeting, and their application in cellular bio-imaging as multifunctional targets/nanocarriers.
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http://dx.doi.org/10.1166/jbn.2020.2899DOI Listing
March 2020

Bioreceptor-free, sensitive and rapid electrochemical detection of patulin fungal toxin, using a reduced graphene [email protected] nanocomposite.

Mater Sci Eng C Mater Biol Appl 2020 Aug 16;113:110916. Epub 2020 Apr 16.

Department of Energy and Materials Engineering, Dongguk University-Seoul, 30 Pildong-ro 1-gil, Seoul 04620, Republic of Korea. Electronic address:

In this research, we successfully synthesized a reduced graphene oxide/tin oxide (rGO/SnO) composite for the electrochemical detection of fungal contaminant, patulin (PAT) that does not require a biological or chemical receptor or specific antibodies. The resulting rGO/SnO composite exhibited promising electrochemical properties and demonstrated outstanding performance in the direct measurement of PAT levels in contaminated apple juice samples. The differential pulse voltammetric response of the rGO/SnO composite electrode exhibited a linear relationship with PAT concentration in the 50-600 nM range and had a lower detection limit of 0.6635 nM. The sensor electrode exhibited high sensitivity, reliable reproducibility, and good selectivity. The designed electrochemical sensor was also tested against the time-consuming and conventional high-performance liquid chromatography (HPLC) approach for the detection of PAT in spiked apple juice samples. We found that the electrochemical sensor had ability to rapidly detect PAT in apple juice samples without the need of extraction or clean-up steps and achieved a higher recovery rate (74.33 ± 0.70 to 99.26 ± 0.70%) within a short-time analysis than did by the HPLC (61.97 ± 1.78 to 84.31 ± 1.96%), thus illustrating its feasibility for use in agricultural and food safety industries.
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http://dx.doi.org/10.1016/j.msec.2020.110916DOI Listing
August 2020

A simple strategy for the synthesis of flower-like textures of Au-ZnO anchored carbon nanocomposite towards the high-performance electrochemical sensing of sunset yellow.

Food Chem 2020 Apr 18;323:126848. Epub 2020 Apr 18.

Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul 100-715, Republic of Korea. Electronic address:

Consumption of sunset yellow (SY) above a certain concentration through food products may leads to adverse health issues. Therefore, it is imperative to develop technologies for rapid and selective detection of SY. Herein, a flower-like reduced graphene oxide (rGO)-graphitic carbon nitride (g-CN)/ZnO-Au nanoparticle (NPs) has been prepared and utilized for the specific detection of SY. The fabricated rGO-g-CN/ZnO-AuNPs composite was characterized and investigated by XRD, FTIR, SEM, TEM, XPS, EIS, and voltammetry techniques. Characterization techniques elucidated the deposition of ZnO-AuNPs on to the rGO-g-CN and successful fabrication of rGO-g-CN/ZnO-AuNPs composite. rGO-g-CN/ZnO-AuNPs composite possesses excellent catalytic activity for the oxidation of SY. Developed rGO-g-CN/ZnO-AuNPs sensor exhibits LOD of 1.34 nM for SY concentrations ranging from 5 to 85 nM. Noteworthily, the sensor has been successfully employed for the detection and recovery of SY in real-time samples. Fabricated composite opens up new avenues to develop electrochemical sensor for food safety.
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http://dx.doi.org/10.1016/j.foodchem.2020.126848DOI Listing
April 2020
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