Publications by authors named "Young-Chae Chang"

156Publications

4-O-methylascochlorin attenuates inflammatory responses induced by lipopolysaccharide in RAW 264.7 macrophages.

Int Immunopharmacol 2021 Jan 11;90:107184. Epub 2020 Dec 11.

Molecular and Cellular Glycobiology Laboratory, Department of Biological Science, SungKyunKwan University, Seoburo 2066, Suwon City, Kyunggi-Do 16419, Republic of Korea; Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Samsung Medical Center, Seoul 06351, South Korea. Electronic address:

View Article and Find Full Text PDF
January 2021

4-O-methylascochlorin activates autophagy by activating AMPK and suppressing c-Myc in glioblastoma.

J Biochem Mol Toxicol 2020 Oct 20;34(10):e22552. Epub 2020 Jun 20.

Department of Medicine, Research Institute of Biomedical Engineering, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.

View Article and Find Full Text PDF
October 2020

Ascofuranone suppresses invasion and F-actin cytoskeleton organization in cancer cells by inhibiting the mTOR complex 1 signaling pathway.

Cell Oncol (Dordr) 2020 Oct 2;43(5):793-805. Epub 2020 Jun 2.

Research Institute of Biomedical Engineering, Department of Medicine, Catholic University of Daegu School of Medicine, 42472, Deagu, Korea.

View Article and Find Full Text PDF
October 2020

Ascofuranone inhibits epidermal growth factor-induced cell migration by blocking epithelial-mesenchymal transition in lung cancer cells.

Eur J Pharmacol 2020 Aug 18;880:173199. Epub 2020 May 18.

Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu, 42472, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
August 2020

PDCD4 inhibits lung tumorigenesis by the suppressing p62-Nrf2 signaling pathway and upregulating Keap1 expression.

Am J Cancer Res 2020 1;10(2):424-439. Epub 2020 Feb 1.

Research Institute of Biomedical Engineering and Department of Cell Biology, Catholic University of Daegu School of Medicine Daegu 705-718, Republic of Korea.

View Article and Find Full Text PDF
February 2020

Bee Venom Suppresses EGF-Induced Epithelial-Mesenchymal Transition and Tumor Invasion in Lung Cancer Cells.

Am J Chin Med 2019 2;47(8):1869-1883. Epub 2019 Dec 2.

Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu 42472, Korea.

View Article and Find Full Text PDF
April 2020

4--methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition.

Biosci Biotechnol Biochem 2019 Dec 8;83(12):2244-2248. Epub 2019 Aug 8.

Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu, Republic of Korea.

View Article and Find Full Text PDF
December 2019

Ascochlorin induces caspase-independent necroptosis in LPS-stimulated RAW 264.7 macrophages.

J Ethnopharmacol 2019 Jul 24;239:111898. Epub 2019 Apr 24.

Molecular and Cellular Glycobiology Laboratory, Department of Biological Science, SungKyunKwan University, Seoburo 2066, Suwon City, Kyunggi-Do, 16419, Republic of Korea; Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Samsung Medical Center, Seoul, 06351, South Korea. Electronic address:

View Article and Find Full Text PDF
July 2019

4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate.

J Antibiot (Tokyo) 2019 05 22;72(5):271-281. Epub 2019 Feb 22.

Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.

View Article and Find Full Text PDF
May 2019

Esculentoside B inhibits inflammatory response through JNK and downstream NF-κB signaling pathway in LPS-triggered murine macrophage RAW 264.7 cells.

Int Immunopharmacol 2019 Mar 9;68:156-163. Epub 2019 Jan 9.

Molecular and Cellular Glycobiology Unit, Department of Biological Sciences, Sungkyunkwan University, Seoburo 2066, Jangan-Gu, Suwon, Gyunggi-Do 16419, Republic of Korea. Electronic address:

View Article and Find Full Text PDF
March 2019

Upregulation of AMPK by 4-O-methylascochlorin promotes autophagy via the HIF-1α expression.

J Cell Mol Med 2018 12 19;22(12):6345-6356. Epub 2018 Oct 19.

Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu, Korea.

View Article and Find Full Text PDF
December 2018

Mitochondrial dysfunction induces the invasive phenotype, and cell migration and invasion, through the induction of AKT and AMPK pathways in lung cancer cells.

Int J Mol Med 2018 Sep 18;42(3):1644-1652. Epub 2018 Jun 18.

Department of Cell Biology, Catholic University of Daegu School of Medicine, Daegu 42472, Republic of Korea.

View Article and Find Full Text PDF
September 2018

Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity.

Oncotarget 2017 Sep 12;8(38):63949-63962. Epub 2017 Jul 12.

Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu 705-718, Republic of Korea.

View Article and Find Full Text PDF
September 2017