Publications by authors named "Young Min Park"

504 Publications

Author Correction: Automated severity scoring of atopic dermatitis patients by a deep neural network.

Sci Rep 2021 Jul 27;11(1):15640. Epub 2021 Jul 27.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Korea.

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http://dx.doi.org/10.1038/s41598-021-94433-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8316353PMC
July 2021

The Risk of Psoriasis in Patients With Allergic Diseases: A Nationwide Population-based Cohort Study.

Allergy Asthma Immunol Res 2021 Jul;13(4):638-645

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

The spectrum of allergic diseases includes atopic dermatitis (AD), allergic rhinitis (AR), and asthma. To date, the association between allergic diseases and psoriasis has not yet been completely evaluated. This study was conducted to determine the risk of psoriasis in patients with allergic diseases. A health screening database, a sub-dataset of the Korean National Health Insurance Service database, was used. All 9,718,722 subjects who underwent health examination in 2009 at age over 20 were included. Subjects with allergic diseases including AD (n = 35,685), AR (n = 1,362,713), asthma (n = 279,451) and control subjects without all three allergic diseases (n = 8,210,042), without AD (n = 9,683,037), without AR (n = 8,356,009) and without asthma group (n = 9,439,271) were analyzed. The subjects were tracked using their medical records during the 8-year period from 2010 to 2017 to identify those who developed psoriasis. Multivariate Cox regression models were used to assess the risk of psoriasis. The incidence probability of psoriasis was analyzed through the Kaplan-Meier method. The incidence of psoriasis per 1,000 person-years was 9.57, 3.78, and 4.28 in the AD, AR, and asthma groups, respectively. The AD group exhibited a significantly increased risk of developing psoriasis compared to subjects without AD (hazard ratio [HR], 3.18; 95% confidence interval [95% CI], 3.05-3.31; < 0.001) after adjustment for confounding factors. The risk of psoriasis was significantly increased in the AR group compared to subjects without AR (HR, 1.32; 95% CI, 1.31-1.34; < 0.001) and asthma group compared to subjects without asthma (HR, 1.30; 95% CI, 1.27-1.33; < 0.001). Allergic diseases, particularly AD, may be a risk factor for psoriasis.
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http://dx.doi.org/10.4168/aair.2021.13.4.638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255348PMC
July 2021

NecroX-5 Can Suppress Melanoma Metastasis by Reducing the Expression of Rho-Family GTPases.

J Clin Med 2021 Jun 25;10(13). Epub 2021 Jun 25.

Department of Biomedicine & Health Sciences, The Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul 06591, Korea.

NecroX-5 (NX-5) is a cell-permeable necrosis inhibitor with cytoprotective effects. Although it has been reported to inhibit lung and breast cancer metastasis by modulating migration, its therapeutic effect on melanoma metastasis is still unknown. In this study, we examined the anti-metastatic effect of NX-5 on melanoma cell lines and its related therapeutic mechanism. The anti-metastatic effect of NX-5 on melanoma cell lines was determined using a transwell migration assay. We performed a quantitative real-time polymerase chain reaction and western blot analysis to measure changes in the expression of mRNA and protein, respectively, for major mediators of Rho-family GTPases after NX-5 treatment in melanoma cells. In addition, after constructing the 3D melanoma model, the expression of Rho-family GTPases was measured by immunohistochemistry. NX-5 (10 μM and 20 μM) treatment significantly reduced melanoma cell migration ( < 0.01). Additionally, NX-5 (20 μM) treatment significantly decreased the mRNA and protein expression levels of Cdc42, Rac1, and RhoA in melanoma cells compared with the untreated group ( < 0.001 and < 0.05, respectively). Immunohistochemistry for our 3D melanoma model showed that Cdc42, Rac1, and RhoA were constitutively expressed in the nuclei of melanoma cells of the untreated group, and NX-5 treatment decreased their expression. These results demonstrate that NX-5 can suppress melanoma metastasis by reducing the expression of Rho-family GTPases.
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http://dx.doi.org/10.3390/jcm10132790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8267632PMC
June 2021

Chronic Ankle Instability Research and Cross-Cultural Adaptation Process Necessity for the Self-Reported Questionnaire.

Iran J Public Health 2021 Apr;50(4):838-839

Division of Health and Kinesiology, Incheon National University, Incheon, Republic of Korea.

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http://dx.doi.org/10.18502/ijph.v50i4.6013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219620PMC
April 2021

Well-demarcated erythematous plaque on the arm.

Indian J Dermatol Venereol Leprol 2021 May 31:1-3. Epub 2021 May 31.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.25259/IJDVL_608_19DOI Listing
May 2021

Care and Management of Voice Change for Thyroid Surgery: Korean Society of Laryngology, Phoniatrics and Logopedics Clinical Practice Guideline.

Clin Exp Otorhinolaryngol 2021 Jun 1. Epub 2021 Jun 1.

Department of Otorhinolaryngology Head and Neck Surgery, Yonsei University College of Medicine, Seoul, Korea.

Voice change is a common complaint after thyroid surgery and has significant impacts on quality of life. The Korean Society of Laryngology, Phoniatrics, and Logopedics set up a task force team to establish guideline recommendations on education, care, and management related to thyroid surgery. The guideline recommendations include preoperative voice education, management of anticipated voice change during surgery, and comprehensive voice care after thyroid surgery, including in-depth information and up-to-date knowledge based on validated literature. The committee constructed 14 key questions (KQ) in three categories: preoperative (KQ1-2), intraoperative (KQ 3-8), and postoperative (KQ 9-14) management and developed 18 evidence-based recommendations. The Delphi survey reached an agreement on each recommendation. Detailed evidence profiles are presented for each recommendation. The level of evidence for each recommendation is classified into high, moderate, and low-quality. The recommendation's strengths are adjusted to consider the level of evidence resulting in the recommendation and are divided into strong and weak. The guidelines are primarily targeted toward physicians who treat thyroid surgery patients and speech-language pathologists participating in patient care. These guidelines will also help primary care physicians, nurses, healthcare policymakers, and patients improve their understanding of voice changes and voice care after thyroid surgery.
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http://dx.doi.org/10.21053/ceo.2021.00633DOI Listing
June 2021

Production of IL-31 in CD45ROCLAH4R T Cells in Atopic Dermatitis.

J Clin Med 2021 May 4;10(9). Epub 2021 May 4.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Korea.

IL-31 is involved in pruritus in atopic dermatitis (AD) and the pathogenesis of AD. However, the mechanism of IL-31 production is not fully understood. We sought to investigate the association between CD45ROCLAH4R T cells and IL-31 production. Immunofluorescence studies were performed retrospectively on punch-biopsy specimens from five people with AD and three healthy controls. In addition, blood samples were collected prospectively from eight patients with AD and eight healthy controls for sorting CD45ROCLAH4R T cells. There was no overlap of patients between the biopsy group and the blood sampling group. Sorted cells were stimulated with 4-methylhistamine (4MH), and the level of IL-31 was measured by an enzyme-linked immunosorbent assay. Immunofluorescence showed co-localization of H4R and IL-31 in lesional AD skin but not in normal skin of healthy controls. The proportion of CLAH4R T cells among CD3CD45RO lymphocytes was 18.3 ± 6.2% in patients with AD and 11.2 ± 7.6% in healthy controls. In the AD group, production of IL-31 by CD45ROCLAH4R T cells increased from 32.4 ± 13.3 pg/mL to 47.5 ± 18.7 pg/mL by 4MH stimulation after 24 h ( < 0.001). However, in the control group, production of IL-31 was 20.1 ± 10.6 pg/mL without and 22.1 ± 9.3 pg/mL with 4MH stimulation ( > 0.05). According to our study, CD45ROCLAH4R T cells are an important source of IL-31 in AD, and may be a target for treatment of IL-31-induced pruritus.
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http://dx.doi.org/10.3390/jcm10091976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124489PMC
May 2021

Recent progress of robotic head and neck surgery using a flexible single port robotic system.

J Robot Surg 2021 May 3. Epub 2021 May 3.

Department of Otorhinolaryngology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.

We performed robotic neck surgery through a transoral or retroauricular approach (RA) using the DaVinci SP and analyzed our experiences to evaluate the feasibility and safety of this system for performing RA neck surgeries. A total of 63 patients were enrolled in this study, consisting of 37 males and 26 females. All operations were successfully completed without significant complication in 63 patients with head and neck tumor. Using DaVinci SP, it is easy to insert three robotic arms into a long and narrow working space because all robotic arms and an endoscope are inserted through a single arm. Using the navigation function of the DaVinci SP, the endoscopic arm could be made into the shape of a "cobra" to secure proper visualization of the surgical site, which helps surgeons identify specific anatomic structures such as cranial nerve or vessels. We did not have any cases where robotic surgery was converted to open surgery due to severe bleeding or technical issues during surgery. The mean operative time was 207 min and the average hospital stay was 6.9 days. The time required for docking the surgical robot was within 10 min on average for DaVinci SP, which was much simpler and faster than that of the previous Si/Xi system. Based on our early experiences performing robotic head and neck surgery using the DaVinci SP, we confirmed that the system provided advanced technical advantages over the previous Si/Xi system in performing robotic surgery.
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http://dx.doi.org/10.1007/s11701-021-01221-8DOI Listing
May 2021

Reconstruction Experience Using Logarithmic Spiral Flap on the Nasal Sidewall.

Ann Dermatol 2020 Jun 24;32(3):260-261. Epub 2020 Apr 24.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.5021/ad.2020.32.3.260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992615PMC
June 2020

Reconstruction Experience Using Logarithmic Spiral Flap on the Nasal Sidewall.

Ann Dermatol 2020 Jun 24;32(3):260-261. Epub 2020 Apr 24.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

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http://dx.doi.org/10.5021/ad.2020.32.3.260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992615PMC
June 2020

Type 2 human papillomavirus E7 attenuates E-cadherin expression in human keratinocytes.

J Microbiol 2021 Jun 29;59(6):616-625. Epub 2021 Mar 29.

Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, 34054, Republic of Korea.

Human papillomaviruses (HPVs) are known to utilize the down-regulation of epithelial (E)-cadherin, a major component of adherens junctions of keratinocytes, to evade host immune surveillance in high-risk group. However, the effects of HPV on the function of E-cadherin in low-risk groups remain unknown. We investigated whether type 2 HPV (HPV-2) E7 could induce alterations in E-cadherin expression in transiently transfected keratinocytes and cell lines expressing HPV-2 E7. To examine the expression pattern of E-cadherin in cutaneous warts and normal skin samples, immunohistochemical analysis was performed. Quantitative real-time polymerase chain reactions, luciferase assays, western blot, immunocytochemistry, and electron microscopy were used to evaluate the mRNA and protein expression levels of E-cadherin in normal human epidermal keratinocytes transfected with HPV-2 E7 plasmid DNA or E7-specific siRNA and in E7-expressing cell lines. E-cadherin expression levels in HPV-2 positive cutaneous warts were significantly decreased compared to those in normal skin (p < 0.05). Similarly, the mRNA and protein expression levels of E-cadherin in E7 transiently transfected cells were significantly decreased compared to those in empty vector-transfected cells. The decreases were restored by transfection with E7-specific siRNA (p < 0.05). Likewise, cell lines expressing E7 showed a decreased expression of E-cadherin. When the cells were cultured in low attachment plates, cell-to-cell aggregation was inhibited. Taken together, our data suggest that HPV-2 E7, the causative agent of cutaneous warts, could mediate the transcriptional repression of E-cadherin.
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http://dx.doi.org/10.1007/s12275-021-0690-yDOI Listing
June 2021

Menopause and the Loss of Skeletal Muscle Mass in Women.

Iran J Public Health 2021 Feb;50(2):413-414

Division of Health and Kinesiology, Incheon National University, Incheon, Republic of Korea.

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http://dx.doi.org/10.18502/ijph.v50i2.5362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956097PMC
February 2021

Automated severity scoring of atopic dermatitis patients by a deep neural network.

Sci Rep 2021 Mar 15;11(1):6049. Epub 2021 Mar 15.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul, 06591, Korea.

Scoring atopic dermatitis (AD) severity with the Eczema Area and Severity Index (EASI) in an objective and reproducible manner is challenging. Automated measurement of erythema, papulation, excoriation, and lichenification severity using images has not yet been investigated. Our aim was to determine whether convolutional neural networks (CNNs) could assess erythema, papulation, excoriation, and lichenification severity at a level of competence comparable to dermatologists. We created a standard dataset of 8,000 clinical images showing AD. Each component of the EASI was scored from 0 to 3 by three dermatologists. We trained four CNNs (ResNet V1, ResNet V2, GoogLeNet, and VGG-Net) with the image dataset and determined which CNN was the most suitable for erythema, papulation, excoriation, and lichenification scoring. The brightness of the images in each dataset was adjusted to - 80% to + 80% of the original brightness (i.e., 9 levels by 20%) to investigate if the CNNs accurately measured scores if image brightness levels were changed. Compared to the dermatologists' scoring, accuracy rates of the CNNs were 99.17% for erythema, 93.17% for papulation, 96.00% for excoriation, and 97.17% for lichenification. CNNs trained with brightness-adjusted images achieved a high accuracy without the need to standardize camera settings. These results suggested that CNNs perform at level of competence comparable to dermatologists for scoring erythema, papulation, excoriation, and lichenification severity.
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http://dx.doi.org/10.1038/s41598-021-85489-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961024PMC
March 2021

Epigallocatechin-3-gallate Can Prevent Type 2 Human Papillomavirus from Suppressing Interferon-Stimulated Genes.

Int J Mol Sci 2021 Feb 28;22(5). Epub 2021 Feb 28.

Program of Immunology & Microbiology, Department of Biomedicine & Health Sciences, Graduate School, The Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, Korea.

Human papillomavirus (HPV) in high-risk groups is known to suppress the type I interferon (IFN) signaling pathway leading to the transcription of interferon-stimulated genes (ISGs), which have many antiviral functions. However, the effects of HPV on the action of various ISGs in low-risk groups are not fully understood. We aimed to investigate whether antiviral ISGs are expressed in transfected keratinocytes with type 2 HPV (HPV-2) . The mRNA and protein expressions of ISGs and type I IFN signaling pathway components were evaluated by quantitative real-time polymerase chain reaction, western blot, immunofluorescence, and/or immunohistochemistry. Compared with normal skin, mRNA expression of all ISGs in HPV-2 positive cutaneous warts was significantly decreased ( < 0.05). In comparison with empty vector transfection, transfection significantly down-regulated the mRNA and protein expressions of ISGs and type I IFN signaling pathway components, which were significantly up-regulated by siRNA transfection ( < 0.05). Interestingly, epigallocatechin-3-gallate (EGCG) pretreatment up-regulated the mRNA and protein expressions of ISGs and type I IFN signaling pathway components, which were significantly down-regulated by transfection ( < 0.05). Our results demonstrate that EGCG is a potential candidate for cutaneous wart prevention.
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http://dx.doi.org/10.3390/ijms22052418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957673PMC
February 2021

Machine learning-based prediction model using clinico-pathologic factors for papillary thyroid carcinoma recurrence.

Sci Rep 2021 Mar 2;11(1):4948. Epub 2021 Mar 2.

Department of Otorhinolaryngology-Head and Neck Surgery, Pusan National University School of Medicine, Pusan National University and Biomedical Research Institute, Pusan National University Hospital, 1-10 Ami-Dong, Seo-Gu, Busan, 602-739, Korea.

This study analyzed the prognostic significance of clinico-pathologic factors, including the number of metastatic lymph nodes (LNs) and lymph node ratio (LNR), in patients with papillary thyroid carcinoma (PTC), and attempted to construct a disease recurrence prediction model using machine learning techniques. We retrospectively analyzed clinico-pathologic data from 1040 patients diagnosed with PTC between 2003 and 2009. We analyzed clinico-pathologic factors related to recurrence through logistic regression analysis. Among the factors that we included, only sex and tumor size were significantly correlated with disease recurrence. Parameters such as age, sex, tumor size, tumor multiplicity, ETE, ENE, pT, pN, ipsilateral central LN metastasis, contralateral central LNs metastasis, number of metastatic LNs, and LNR were input for construction of a machine learning prediction model. The performance of five machine learning models related to recurrence prediction was compared based on accuracy. The Decision Tree model showed the best accuracy at 95%, and the lightGBM and stacking model together showed 93% accuracy. Among those factors mentioned above, LNR and contralateral LN metastasis were used as important features in all machine learning prediction models. We confirmed that all machine learning prediction models showed an accuracy of 90% or more for predicting disease recurrence in PTC. LNR and contralateral LN metastasis were used as important features for constructing a robust machine learning prediction model. In the future, we have a plan to perform large-scale multicenter clinical studies to improve the performance of our prediction models and verify their clinical effectiveness.
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http://dx.doi.org/10.1038/s41598-021-84504-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925610PMC
March 2021

Genomic Association Study for Cognitive Impairment in Parkinson's Disease.

Front Neurol 2020 4;11:579268. Epub 2021 Feb 4.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Cognitive impairment is very common in Parkinson's disease (PD) and constitutes the most debilitating complication of this disease. However, to date, few studies have investigated a genome-wide association in the development of cognitive impairment of PD. We aimed to identify the genetic loci associated with cognitive impairment in patients with sporadic PD by ethnicity-specific genotyping. We recruited 1,070 patients with PD and performed a genome-wide association study using the Korean Chip, a microarray chip containing 827,400 single-nucleotide polymorphisms (SNPs) optimized for the Korean population. Multiple logistic regression models adjusting for age, sex, years of education, and disease duration were used to compare between patients with and without cognitive impairment, which was defined using the Mini-Mental Status Examination (MMSE) score (MMSE score ≥ 26 vs. < 26) or the Montreal Cognitive Assessment (MoCA) score (MoCA score ≥24 vs. < 24). SNP rs10495397 was most significantly associated with cognitive impairment based on the MMSE scores (OR = 3.21; 95% CI = 1.96-5.25, = 3.36 × 10) and showed the strongest association with cognitive impairment based on the MoCA scores. However, none of the SNPs were statistically significant after Bonferroni correction. may play a role in cognitive impairment in PD by the pathogenic mechanism of neuroinflammation. However, more studies are needed to replicate and validate the results of our functional study.
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http://dx.doi.org/10.3389/fneur.2020.579268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890115PMC
February 2021

The differential expression of EPHB4 and ephrin B2 in cutaneous squamous cell carcinoma according to the grade of tumor differentiation: a clinicopathological study.

Int J Dermatol 2021 Jun 17;60(6):736-741. Epub 2021 Feb 17.

Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: EPHB4 and its ligand, ephrin B2, which are receptor tyrosine kinases of the erythropoietin-producing hepatocellular (EPH) family, are known to be linked to several human cancers. The aim of this study was to investigate their expression patterns in cutaneous squamous cell carcinoma (CSCC) in association with tumor differentiation and other variable clinical characteristics.

Materials And Methods: Immunohistochemical staining for EPHB4 and ephrin B2 was performed in 32 cases of CSCC with different histologic grades. The clinical characteristics and histologic grades of CSCC were evaluated in association with EPHB4 and ephrin B2 expression patterns.

Results: EPHB4 and ephrin B2 expression levels were significantly inversely proportional to the grade of differentiation of CSCC (P < 0.001 and P < 0.001, respectively).

Conclusion: These results indicated that EPHB4 and ephrin B2 can be useful markers for poorly differentiated CSCC.
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http://dx.doi.org/10.1111/ijd.15445DOI Listing
June 2021

Bone Mineral Density in Different Menopause Stages is Associated with Follicle Stimulating Hormone Levels in Healthy Women.

Int J Environ Res Public Health 2021 01 29;18(3). Epub 2021 Jan 29.

Department of Medicine, Division of Geriatric Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Although estradiol (E) has been believed to be the most critical factor in the menopause-associated decrease in bone mineral density (BMD), the role of increasing follicle stimulating hormone (FSH) during menopause is relatively unclear. We determined the extent to which hip and lumbar spine BMD differ among the stages of menopause in healthy women, and whether BMD is associated with FSH and E levels. A cross-sectional study of 141 healthy women classified as premenopausal (Pre; 38 ± 6 yrs; mean ± SD, = 30), early perimenopausal (EPeri; 50 ± 3yrs, = 31), late perimenopausal (LPeri; 50 ± 4yrs, = 30), early postmenopausal (EPost; 55 ± 3yrs, = 24), or late postmenopausal (LPost; 62 ± 4 yrs, = 26), was conducted. Spine/hip BMD and sex hormones were measured using dual-energy X-ray absorptiometry and enzymatic/colorimetric methods, respectively. Compared to EPeri, spine BMD was lower ( < 0.05) in LPeri, EPost, and LPost and hip BMD was lower ( < 0.05) in EPost and LPost. BMD was inversely associated with FSH (spine: r = -0.341; hip: r = -0.271, < 0.05) and directly associated with E (spine: r = 0.274; hip: r = 0.256, < 0.05). The menopause-related loss of spine and hip BMD is associated not only with low E but also higher FSH. Future studies are essential to delineating the mechanisms by which FSH regulates bone health in aging women.
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http://dx.doi.org/10.3390/ijerph18031200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908273PMC
January 2021

High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria.

Sci Rep 2021 Jan 21;11(1):1875. Epub 2021 Jan 21.

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

In a previous study, we found that higher waist circumference (WC) and higher body mass index (BMI) both increase the risk of chronic spontaneous urticaria (CSU). The aim of this study was to determine whether WC and BMI also increase the duration of CSU. We used multivariable Cox proportional hazards models to determine the hazard ratio (HR) for longer disease duration (longer than 3 years) according to WC and BMI. A total of 52,667 subjects were enrolled and their mean age was 54.5. After adjustments for other confounding variables the high WC/high BMI group had 1.062 times higher HR (95% CI, 1.028-1.098) than the normal WC/normal BMI group. Interestingly, the high WC/normal BMI group showed a significantly higher HR (1.053; 95% CI, 1.008-1.101) than the normal WC/normal BMI group, but not the normal WC/high BMI group (0.998; 95% CI, 0.951-1.046). Taken together, our results suggest that high WC rather than high BMI is a predictive risk factor for the longer disease duration of CSU.
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http://dx.doi.org/10.1038/s41598-021-81484-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7820591PMC
January 2021

Coronectomy of Mandibular Third Molar: Four Years of Follow-Up of 130 Cases.

Medicina (Kaunas) 2020 Nov 27;56(12). Epub 2020 Nov 27.

Department of Stomatology, Tuscan Stomatologic Institute, Foundation for Dental Clinic, Research and Continuing Education, 55042 Forte dei Marmi, Italy.

Inferior wisdom teeth extraction surgery may have some complications that, in some cases, could be prevented by a correct diagnosis and minimal surgery. Coronectomy is a technique used for wisdom teeth surgery where only the crown is extracted and the root/roots are left in situ. This procedure may be controversial, but it could limit the common risks of the extraction procedure. Nowadays, the indication and contraindication of this technique are debated, and clinicians normally extract the entire tooth. The following case series includes the data and follow-up radiographs of 130 patients who received a coronectomy, reporting the safety of the procedure. After a mean follow-up period of four years, no complications occurred. A total of 13 patients showed mobile roots but had no complications or symptoms. The roots migrated in a mesial or coronal direction in 31 patients; in 4 cases, they were removed because of patient preference. Coronectomy is a useful oral surgical procedure in certain complicated cases of mandibular wisdom tooth extraction.
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http://dx.doi.org/10.3390/medicina56120654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7760348PMC
November 2020

Mismatch Negativity and Loudness Dependence of Auditory Evoked Potentials among Patients with Major Depressive Disorder, Bipolar II Disorder, and Bipolar I Disorder.

Brain Sci 2020 Oct 28;10(11). Epub 2020 Oct 28.

Department of Psychiatry, Inje Univeristy, Ilsan Paik Hospital, Goyang 10380, Korea.

Mismatch negativity (MMN) and loudness dependence of auditory evoked potentials (LDAEP), which are event-related potentials, have been investigated as biomarkers. MMN indicates the pre-attentive function, while LDAEP may be an index of central serotonergic activity. This study aimed to test whether MMN and LDAEP are useful biological markers for distinguishing patients with bipolar disorder (BD) and major depressive disorder (MDD), as well as the relationship between MMN and LDAEP. Fifty-five patients with major depressive episodes, aged 20 to 65 years, who had MDD ( = 17), BD type II (BIID) ( = 27), and BD type I (BID) ( = 11), were included based on medical records. Patients with MDD had a higher MMN amplitude than those with BID. In addition, the MMN amplitude in F4 positively correlated with the Korean version of mood disorder questionnaire scores ( = 0.37, = 0.014), while the MMN amplitude in F3 correlated negatively with LDAEP ( = -0.30, = 0.024). The odds ratios for the BID group and some variables were compared with those for the MDD group using multinomial logistic regression analysis. As a result, a significant reduction of MMN amplitude was found under BID diagnosis compared to MDD diagnosis ( = 0.015). This study supported the hypothesis that MMN amplitude differed according to MDD, BIID, and BID, and there was a relationship between MMN amplitude and LDAEP. These findings also suggested that BID patients had a reduced automatic and pre-attentive processing associated with serotonergic activity or N-methyl-D-aspartate receptor.
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http://dx.doi.org/10.3390/brainsci10110789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692302PMC
October 2020

Survival Benefits From Surgery for Stage IVa Head and Neck Squamous Cell Carcinoma: A Multi-institutional Analysis of 1,033 Cases.

Clin Exp Otorhinolaryngol 2021 May 25;14(2):225-234. Epub 2020 Sep 25.

Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea.

Objectives: Head and neck squamous cell carcinomas (HNSCs) are frequently diagnosed at the locoregional advanced stage (stage IVa), but controversy remains regarding whether stage IVa HSNCs should be treated with upfront surgery or definitive chemoradiation therapy (CRT). The purpose of this study was to compare overall survival (OS) and disease-free survival (DFS) in patients with stage IVa HNSC treated primarily by surgery with curative intent with/without (neo)adjuvant treatment (surgery group) versus those treated primarily with CRT (CRT group).

Methods: We reviewed data of 1,033 patients with stage IVa HNSC treated with curative intent at 17 cancer centers between 2010 and 2016.

Results: Among 1,033 patients, 765 (74.1%) received upfront surgery and 268 (25.9%) received CRT. The 5-year OS and DFS rates were 64.4% and 62.0% in the surgery group and 49.5% and 45.4% in the CRT group, respectively. In multivariate analyses, OS and DFS were better in the surgery group than in the CRT group (odds ratio [OR] for death, 0.762; 95% confidence interval [CI], 0.592-0.981; OR for recurrence, 0.628; 95% CI, 0.492-0.802). In subgroup analyses, the OS and DFS of patients with oropharyngeal cancer were better in the surgery group (OR for death, 0.548; 95% CI, 0.341-0.879; OR for recurrence, 0.598; 95% CI, 0.377-0.948). In the surgery group, patients with laryngeal cancer showed better OS (OR for death, 0.432; 95% CI, 0.211-0.882), while those with hypopharyngeal cancer DFS was improved (OR for recurrence, 0.506; 95% CI, 0.328-0.780).

Conclusion: A survival benefit from surgery may be achieved even in patients with stage IVa HNSC, particularly those with oropharyngeal and laryngeal cancer. Surgery led to a reduction in the recurrence rate in patients with hypopharyngeal cancer.
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http://dx.doi.org/10.21053/ceo.2020.01732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8111393PMC
May 2021

Linear Vertigo in Benign Paroxysmal Positional Vertigo: Prevalence and Mechanism.

Cerebellum 2021 Apr 5;20(2):160-168. Epub 2020 Oct 5.

Dizziness Center, Clinical Neuroscience Center, and Department of Neurology, Seoul National University Bundang Hospital, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea.

This study aimed to determine the prevalence and mechanism of linear vertigo reported by the patients during the attacks of benign paroxysmal positional vertigo (BPPV). We prospectively evaluated the characteristics (rotational vs. linear) of positional vertigo in 70 patients with posterior and horizontal canal BPPV using a questionnaire allowing multiple choices. In patients with linear vertigo, we further assessed the directionality of linear vertigo. We adopted the velocity-storage model to explain the occurrence and direction of linear vertigo in these patients with BPPV. Patients reported only rotational vertigo in 46 (46/70, 65.7%), only linear vertigo in 10 (14.3%), and both rotational and linear vertigo in 14 (20%). The patients experienced fear from rotational vertigo in 54 (54/70, 77.1%) and from linear vertigo in 20 (20/70, 28.6%). The direction of linear vertigo was concordant with the direction of inertial acceleration predicted by the velocity-storage model. Patients with BPPV may experience linear as well as rotational vertigo during the attacks. This linear vertigo may be ascribed to centrally estimated inertial acceleration.
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http://dx.doi.org/10.1007/s12311-020-01196-6DOI Listing
April 2021

Interaction between adverse childhood experiences and polygenic risk in patients with bipolar disorder.

Transl Psychiatry 2020 09 22;10(1):326. Epub 2020 Sep 22.

Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.

The interaction between genes and environment often occurs when they depend on one another. We hypothesized that adverse childhood experiences (ACEs) would interact with genetic predispositions to bipolar disorder (BD), demonstrating earlier age at onset (AAO) and worse clinical outcomes. We aimed to clarify the effects of the interaction between ACEs and genetic susceptibility using polygenic risk score (PRS) on AAO and clinical outcomes. Single nucleotide polymorphisms and clinical data, including ACEs, were obtained from the Bipolar Genomic Study, which contains a large sample of BD participants. A total of 1615 subjects with BD I were obtained and divided into two groups according to the presence or absence of ACEs and an additional four groups based on the number of ACEs (none versus one versus two versus ≥ three types). ACEs was evaluated using the childhood life events scale (CLES). BD-PRS was obtained from the Psychiatric Genomics Consortium, which compared BD patients and healthy controls. The BD-PRS was higher in the group with ACEs than without ACEs at most p-value thresholds. In multivariate linear regression analyses, both groups with more ACEs and higher BD-PRS were independently and interactively associated with an earlier AAO of BD; however, only greater ACEs were associated with worsened clinical outcome. These findings highlight the clinical importance of evaluating ACEs and polygenic risk in research of the etiology of BD.
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http://dx.doi.org/10.1038/s41398-020-01010-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7509781PMC
September 2020

Solution and Evaporation Hybrid Approach to Enhance the Stability and Pattern Resolution Characteristics of Organic Light-Emitting Diodes.

ACS Appl Mater Interfaces 2020 Oct 28;12(40):45064-45072. Epub 2020 Sep 28.

Micro/Nano Scale Manufacturing R&D Group, Korea Institute of Industrial Technology, Ansan-si 15588, Gyeonggi-do, Republic of Korea.

The solution process and vacuum evaporation, both fabrication methods for conventional organic light-emitting diodes (OLEDs), are intrinsically restricted with regard to their ability to enhance pattern resolutions and film stability outcomes. Here, we introduce a novel approach of the solution process followed by intense pulsed light (IPL) evaporation for producing high-resolution line patterns of OLEDs. Through control of the wettability between the banks and microchannels via a mask-free selective surface treatment, we successfully deposited phosphorescent green and red inks only into the microchannels. Then, high-resolution patterns of an emitting layer (EML) layer were uniformly evaporated onto the device substrate using IPL evaporation. Ultimately, we fabricated green and red phosphorescent OLED devices with a high pixel density of a line-patterned EML with a width of 6 μm and a pitch of 13.6 μm. In addition, we demonstrated that the IPL-evaporated films have many advantages compared to those fabricated by the conventional solution process. We also showed that the IPL evaporation process can be less sensitive to problems related to the aggregation of organic molecules during a drying or annealing process. Hence, the device performance and lifetime of the IPL-evaporated OLEDs were enhanced compared to those of the spin-coated OLEDs.
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http://dx.doi.org/10.1021/acsami.0c12749DOI Listing
October 2020

Height Is Associated with Dyslipidemia in Korean Premenopausal Women: Data from the Korea National Health and Nutrition Examination Survey.

Cardiology 2020 10;145(11):736-739. Epub 2020 Sep 10.

Cardiology Division, Department of Internal Medicine, Gachon University College of Medicine, Incheon, Republic of Korea,

Background: The association between height and cardiovascular disease (CVD) has been reported in epidemiological studies for decades; however, the mechanism for this relationship is still unclear. We previously reported that dyslipidemia was associated with adult height in Korean men without CVD.

Objectives: This study explored the potential -relationship between height and dyslipidemia in premenopausal women.

Methods: This study used data from the 2007-2016 Korea National Health and Nutritional Examination Survey (KNHANES). We identified 16,361 premenopausal women aged ≥19 years without a history of CVD (myocardial infarction/stroke) or cancer. Fasting total cholesterol, triglyceride, and high-density lipoprotein cholesterol (HDL-C) levels were measured. Dyslipidemia was further classified as hypercholesterolemia (total cholesterol level ≥240 mg/dL or treatment with lipid-lowering medications), hypertriglyceridemia (triglyceride level ≥200 mg/dL), and low HDL-C (HDL-C level <40 mg/dL). Subjects were divided into four groups by their height (<155, 155-159.9, 160-164.9, and ≥165 cm), and the prevalence of dyslipidemia was compared.

Results: Multiple regression analysis revealed that short premenopausal women had a higher likelihood of hypercholesterolemia (ptrend = 0.002), hypertriglyceridemia (ptrend = 0.010), and low HDL-C (ptrend = 0.002) when adjusted for age, comorbidities, waist circumference, health-related habits, and economic status.

Conclusion: There was a dose-dependent correlation between adult height and adverse lipid profile in premenopausal Korean women who did not have CVD. This finding could serve as further evidence that dyslipidemia can be a link between shortness and CVD.
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http://dx.doi.org/10.1159/000509631DOI Listing
September 2020

Selective Nonenzymatic Amperometric Detection of Lactic Acid in Human Sweat Utilizing a Multi-Walled Carbon Nanotube (MWCNT)-Polypyrrole Core-Shell Nanowire.

Biosensors (Basel) 2020 Aug 28;10(9). Epub 2020 Aug 28.

Surface Technology Group, Korea Institute of Industrial Technology (KITECH), Incheon 21999, Korea.

Lactic acid plays an important role as a biochemical indicator for sports medicine and clinical diagnosis. The detection of lactic acid in sweat is a promising technique without any intrusive inconvenience or risk of infection. In this study, we present a selective nonenzymatic amperometric detection method for lactic acid in human sweat utilizing a multi-wall carbon nanotube (MWCNT)-polypyrrole core-shell nanowire. Because polypyrrole is a p-type conducting polymer, onto which anions are exclusively doped, leading to charge transfer, it offers selective detection for lactate anions at a specific potential, while being inert to the neutral and cationic species contained in human sweat. A chronoamperometric study reveals good sensing performance for lactic acid with a high sensitivity of 2.9 μA mM cm and detection limit of 51 μM. Furthermore, the MWCNT-polypyrrole nanowire exhibits excellent selectivity for lactic acid over interfering species, such as sodium chloride, glucose, urea, and riboflavin, which coexist with lactic acid in sweat. Finally, a nonenzymatic amperometric sensor for the selective detection of lactic acid in human sweat is demonstrated on commercial flexible electrodes. The results demonstrate the potential applications of the MWCNT-polypyrrole core-shell nanowire as a nonenzymatic amperometric lactate sensor.
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http://dx.doi.org/10.3390/bios10090111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559985PMC
August 2020

Genomic Analysis Identifies New Loci Associated With Motor Complications in Parkinson's Disease.

Front Neurol 2020 7;11:570. Epub 2020 Jul 7.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Parkinson's disease (PD) is a common neurodegenerative disorder, characterized by a clinical symptomatology involving both motor and non-motor symptoms. Motor complications associated with long-term dopaminergic treatment include motor fluctuations and levodopa-induced dyskinesia (LID), which may have a major impact on the quality of life. The clinical features and onset time of motor complications in the disease course are heterogeneous, and the etiology remains unknown. We aimed to identify genomic variants associated with the development of motor fluctuations and LID at 5 years after the onset of PD. Genomic data were obtained using Affymetrix Axiom KORV1.1 array, including an imputation genome-wide association study (GWAS) grid and other GWAS loci; functional variants of the non-synonymous exome; pharmacogenetic variants; variants in genes involved in absorption, distribution, metabolism, and excretion of drugs; and expression quantitative trait loci in 741 patients with PD. single-nucleotide polymorphism (SNP) rs10760490 was nominally associated with the occurrence of motor fluctuations at 5 years after the onset of PD [odds ratio (OR) = 2.9, 95% confidence interval (CI) = 1.8-4.8, = 6.5 × 10]. SNP rs144125291 was significantly associated with the occurrence of LID (OR = 5.5, 95% CI = 2.9-10.3, = 7.88 × 10) and was still significant after Bonferroni correction. Several other genetic variants were associated with the occurrence of motor fluctuations or LID, but the associations were not significant after Bonferroni correction. This study identified new loci associated with the occurrence of motor fluctuations and LID at 5 years after the onset of PD. However, further studies are needed to confirm our findings.
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http://dx.doi.org/10.3389/fneur.2020.00570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358548PMC
July 2020

Multiple yellow-brown papules on the penis.

Cutis 2020 Jun;105(6):E44-E45

Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, South Korea.

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June 2020

The KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children: Part 2. Management of H1-Antihistamine-Refractory Chronic Urticaria.

Allergy Asthma Immunol Res 2020 Sep;12(5):750-770

Department of Dermatology, School of Medicine, Eulji University, Daejeon, Korea.

Quite a few patients with chronic spontaneous urticaria (CSU) are refractory to H₁-antihistamines, even though the dose of H₁-antihistamines is increased up to 4-fold. CSU that is not controlled with H₁-antihistamines results in increased disease burden. Several immunomodulators have been used to manage these patients. The guidelines reported herein are connected to Part 1 of the KAAACI/KDA Evidence-Based Practice Guidelines for Chronic Spontaneous Urticaria in Korean Adults and Children, and aimed to provide evidence-based recommendations for the management of H₁-antihistamine-refractory CSU. Part 2 focuses on the more commonly used additional treatment options for refractory CSU, including omalizumab, cyclosporine, leukotriene receptor antagonist, dapsone, methotrexate, and phototherapy. The evidence to support their efficacy, dosing, safety, and selection of these agents is systematically reviewed. To date, for patients with refractory CSU, the methodologically sound data to evaluate the use of omalizumab has been growing; however, the evidence of other immunomodulators and phototherapy is still insufficient. Therefore, an individualized stepwise approach with a goal of achieving complete symptom control and minimizing side effects can be recommended. Larger controlled studies are needed to elevate the level of evidence to select a rational therapeutic agent for patients with refractory CSU.
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http://dx.doi.org/10.4168/aair.2020.12.5.750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7346997PMC
September 2020
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