Young Chan Chae

Young Chan Chae

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Young Chan Chae

Young Chan Chae

Publications by authors named "Young Chan Chae"

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28Publications

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Phospholipase C-β1 potentiates glucose-stimulated insulin secretion.

FASEB J 2019 Oct 3;33(10):10668-10679. Epub 2019 Jul 3.

School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, South Korea.

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http://dx.doi.org/10.1096/fj.201802732RRDOI Listing
October 2019

ITGB4-mediated metabolic reprogramming of cancer-associated fibroblasts.

Oncogene 2019 Sep 18. Epub 2019 Sep 18.

Brain Korea 21 Plus Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.

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http://dx.doi.org/10.1038/s41388-019-1014-0DOI Listing
September 2019

Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer.

EBioMedicine 2019 Sep 14. Epub 2019 Sep 14.

Prostate Cancer Discovery and Development Program, USA; Immunology, Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2019.09.017DOI Listing
September 2019

Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.

Am J Respir Crit Care Med 2018 07;198(1):90-103

1 Pulmonary Hypertension Research Group, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec City, Québec, Canada.

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http://dx.doi.org/10.1164/rccm.201708-1751OCDOI Listing
July 2018

Cancer stem cell metabolism: target for cancer therapy.

BMB Rep 2018 Jul;51(7):319-326

Department of Physiology, School of Medicine, Pusan National University, Yangsan 50621; Research Institute of Convergence Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50621, Korea.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089865PMC
http://dx.doi.org/10.5483/bmbrep.2018.51.7.112DOI Listing
July 2018

Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation.

Korean J Physiol Pharmacol 2018 Mar 23;22(2):203-213. Epub 2018 Feb 23.

Department of Physiology, Laboratory for Vascular Medicine and Stem Cell Biology, Convergence Stem Cell Research Center, Medical Research Institute, Pusan National University School of Medicine, Yangsan 50612, Korea.

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http://dx.doi.org/10.4196/kjpp.2018.22.2.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5840079PMC
March 2018

PLCγ1: Potential arbitrator of cancer progression.

Adv Biol Regul 2018 01 8;67:179-189. Epub 2017 Nov 8.

School of Life Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.jbior.2017.11.003DOI Listing
January 2018

A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.

Oncotarget 2017 Dec 11;8(68):112184-112198. Epub 2017 Dec 11.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA, USA.

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http://dx.doi.org/10.18632/oncotarget.23097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5762502PMC
December 2017

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.

Cancer Cell 2016 08;30(2):257-272

Prostate Cancer Discovery and Development Program, Tumor Microenvironment and Metastasis Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131882PMC
August 2016

Pairwise detection of site-specific receptor phosphorylations using single-molecule blotting.

Nat Commun 2016 Mar 24;7:11107. Epub 2016 Mar 24.

Department of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.

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http://dx.doi.org/10.1038/ncomms11107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820850PMC
March 2016

PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.

Proc Natl Acad Sci U S A 2015 Jul 29;112(28):8638-43. Epub 2015 Jun 29.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104; Tumor Microenvironment and Metastasis Program, The Wistar Institute, Philadelphia, PA 19104;

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http://dx.doi.org/10.1073/pnas.1500722112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507184PMC
July 2015

Adaptive mitochondrial reprogramming and resistance to PI3K therapy.

J Natl Cancer Inst 2015 Mar 3;107(3). Epub 2015 Feb 3.

Prostate Cancer Discovery and Development Program (JCG, MT, YCC, SL, MCC, JHS, LRL, DCA), Tumor Microenvironment and Metastasis Program (JCG, MT, YCC, SL, MCC, JHS, DCA), Center for Systems and Computational Biology (AVK), and Center for Chemical Biology and Translational Medicine (DCS), The Wistar Institute, Philadelphia, PA; Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY (MDS); Istituto Nazionale Genetica Molecolare "Romeo and Enrica Invernizzi," Milan, Italy (VV); Division of Pathology (VV, AF, SB), Division of Neurosurgery (PR), and Division of Surgery (MG), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Metabolon, Inc. Durham, NC (RDM); Department of Pathophysiology and Organ Transplant, University of Milan, Milan, Italy (SB); Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA (LRL).

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http://dx.doi.org/10.1093/jnci/dju502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565533PMC
March 2015

Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.

Cell Rep 2014 Aug 31;8(3):671-7. Epub 2014 Jul 31.

Prostate Cancer Discovery and Development Program, The Wistar Institute, Philadelphia, PA 19104, USA; Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA 19104, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.06.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127146PMC
August 2014

Protein kinase Cdelta-mediated phosphorylation of phospholipase D controls integrin-mediated cell spreading.

Mol Cell Biol 2010 Nov 23;30(21):5086-98. Epub 2010 Aug 23.

Division of Molecular and Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.

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http://dx.doi.org/10.1128/MCB.00443-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953051PMC
November 2010

Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.

Cell Signal 2009 Dec 8;21(12):1818-26. Epub 2009 Aug 8.

Division of Molecular and Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, 790-784, Republic of Korea.

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http://dx.doi.org/10.1016/j.cellsig.2009.07.017DOI Listing
December 2009

Phospholipase D activity regulates integrin-mediated cell spreading and migration by inducing GTP-Rac translocation to the plasma membrane.

Mol Biol Cell 2008 Jul 14;19(7):3111-23. Epub 2008 May 14.

Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.

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http://dx.doi.org/10.1091/mbc.e07-04-0337DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441685PMC
July 2008

RGS2 promotes formation of neurites by stimulating microtubule polymerization.

Cell Signal 2006 Dec 23;18(12):2182-92. Epub 2006 May 23.

Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyungbuk 790-784, South Korea.

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http://dx.doi.org/10.1016/j.cellsig.2006.05.006DOI Listing
December 2006

Inhibition of muscarinic receptor-linked phospholipase D activation by association with tubulin.

J Biol Chem 2005 Feb 16;280(5):3723-30. Epub 2004 Nov 16.

Division of Molecular and Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.

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http://dx.doi.org/10.1074/jbc.M406987200DOI Listing
February 2005

Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner.

J Biol Chem 2004 Apr 26;279(16):16339-48. Epub 2004 Jan 26.

Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, 790-784 Republic of Korea.

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http://dx.doi.org/10.1074/jbc.M310976200DOI Listing
April 2004