Youna Hu

Youna Hu

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Youna Hu

Youna Hu

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Whole exome sequencing reveals HSPA1L as a genetic risk factor for spontaneous preterm birth.

PLoS Genet 2018 07 12;14(7):e1007394. Epub 2018 Jul 12.

Division of Human Genetics, Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, March of Dimes Prematurity Research Center Ohio Collaborative, Cincinnati, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1007394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042692PMC
July 2018

Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.

N Engl J Med 2017 09 6;377(12):1156-1167. Epub 2017 Sep 6.

From the Division of Human Genetics (G.Z., L.J.M.), Center for Autoimmune Genomics and Etiology (M.T.W., D.E.M., X.C., C.R.F., L.C.K.) and the Divisions of Biomedical Informatics and Developmental Biology (M.T.W.), Cincinnati Children's Hospital Medical Center, and the Center for Prevention of Preterm Birth, Perinatal Institute, Cincinnati Children's Hospital Medical Center and March of Dimes Prematurity Research Center Ohio Collaborative (G.Z., L.M.M., M.P., J.M.H., L.J.M.), Cincinnati; the Department of Epidemiology Research, Statens Serum Institut (B.F., X.L., F.G., H.A.B., M.M.), and the Department of Clinical Medicine, University of Copenhagen (M.M.), Copenhagen, and the Research Unit of Gynecology and Obstetrics, Institute of Clinical Research, University of Southern Denmark, Odense (E.A.N.) - all in Denmark; the Department of Obstetrics and Gynecology, Sahlgrenska University Hospital Östra (J.B., V.S.), the Department of Obstetrics and Gynecology, Institute of Clinical Sciences (J.J.), and the Department of Obstetrics and Gynecology (B.J.), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 23andMe, Mountain View (N.L., P.-P.J., L.R., D.A.H., Y.H.), and the Department of Medicine, Stanford University School of Medicine, Stanford (M.M.) - both in California; the Department of Ecology and Evolutionary Biology, Yale University (A.R.C., G.P.W., M.C.N., J.M.), and the Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale Medical School (G.P.W.), New Haven, and the Yale Systems Biology Institute, West Haven (A.R.C., G.P.W., M.C.N., J.M.) - all in Connecticut; the Department of Obstetrics and Gynecology, Wayne State University, Detroit (G.P.W.); the PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, and the Department of Children and Adolescents, Oulu University Hospital, Oulu (M.K.K., M.R., J.M.H., M.H.), and the Institute for Molecular Medicine Finland, University of Helsinki (A.P.), and Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital (K.T.), Helsinki - all in Finland; the Analytic and Translational Genetics Unit, Department of Medicine, the Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry, and the Department of Neurology, Massachusetts General Hospital, Boston (A.P.), and the Program in Medical and Population Genetics and the Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge (A.P.) - both in Massachusetts; the Departments of Pediatrics (A.M., B.B.) and Epidemiology (K.K.R.), College of Public Health, and the Department of Pediatrics (K.K.R.), Carver College of Medicine, University of Iowa, Iowa City; the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom (G.D.S.); and the Department of Genetics and Bioinformatics, Area of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo (B.J.).

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http://www.nejm.org/doi/10.1056/NEJMoa1612665
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http://dx.doi.org/10.1056/NEJMoa1612665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5561422PMC
September 2017

Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus.

Pain 2016 11;157(11):2571-2581

aHuman Genetics and Computational Biomedicine, Pfizer WRD, Cambridge, United Kingdom bNeuroscience and Pain Research Unit, Pfizer Ltd, Cambridge, United Kingdom cResearch Statistics, Pfizer WRD, Groton, CT, USA dResearch Statistics, Pfizer WRD, Pfizer Ltd, Cambridge, United Kingdom e23andMe, Inc, Mountain View, CA, USA.

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http://dx.doi.org/10.1097/j.pain.0000000000000678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436737PMC
November 2016

RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data.

Bioinformatics 2016 05 15;32(9):1423-6. Epub 2016 Feb 15.

Division of Biostatistics and Bioinformatics, Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA and Institute for Personalized Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1093/bioinformatics/btw079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848408PMC
May 2016

GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person.

Nat Commun 2016 Feb 2;7:10448. Epub 2016 Feb 2.

23andMe, Inc., 899 W Evelyn Avenue, Mountain View, California 94043 USA.

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http://dx.doi.org/10.1038/ncomms10448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740817PMC
February 2016

Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

N Engl J Med 2014 Jul 18;371(1):22-31. Epub 2014 Jun 18.

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http://dx.doi.org/10.1056/NEJMoa1307095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180269PMC
July 2014

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Authors:
Leslie A Lange Youna Hu He Zhang Chenyi Xue Ellen M Schmidt Zheng-Zheng Tang Chris Bizon Ethan M Lange Joshua D Smith Emily H Turner Goo Jun Hyun Min Kang Gina Peloso Paul Auer Kuo-Ping Li Jason Flannick Ji Zhang Christian Fuchsberger Kyle Gaulton Cecilia Lindgren Adam Locke Alisa Manning Xueling Sim Manuel A Rivas Oddgeir L Holmen Omri Gottesman Yingchang Lu Douglas Ruderfer Eli A Stahl Qing Duan Yun Li Peter Durda Shuo Jiao Aaron Isaacs Albert Hofman Joshua C Bis Adolfo Correa Michael E Griswold Johanna Jakobsdottir Albert V Smith Pamela J Schreiner Mary F Feitosa Qunyuan Zhang Jennifer E Huffman Jacy Crosby Christina L Wassel Ron Do Nora Franceschini Lisa W Martin Jennifer G Robinson Themistocles L Assimes David R Crosslin Elisabeth A Rosenthal Michael Tsai Mark J Rieder Deborah N Farlow Aaron R Folsom Thomas Lumley Ervin R Fox Christopher S Carlson Ulrike Peters Rebecca D Jackson Cornelia M van Duijn André G Uitterlinden Daniel Levy Jerome I Rotter Herman A Taylor Vilmundur Gudnason David S Siscovick Myriam Fornage Ingrid B Borecki Caroline Hayward Igor Rudan Y Eugene Chen Erwin P Bottinger Ruth J F Loos Pål Sætrom Kristian Hveem Michael Boehnke Leif Groop Mark McCarthy Thomas Meitinger Christie M Ballantyne Stacey B Gabriel Christopher J O'Donnell Wendy S Post Kari E North Alexander P Reiner Eric Boerwinkle Bruce M Psaty David Altshuler Sekar Kathiresan Dan-Yu Lin Gail P Jarvik L Adrienne Cupples Charles Kooperberg James G Wilson Deborah A Nickerson Goncalo R Abecasis Stephen S Rich Russell P Tracy Cristen J Willer

Am J Hum Genet 2014 Feb;94(2):233-45

Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928660PMC
February 2014

Accurate local-ancestry inference in exome-sequenced admixed individuals via off-target sequence reads.

Am J Hum Genet 2013 Nov;93(5):891-9

Department of Integrative Biology, University of California Berkeley, Berkeley, CA 94720, USA; Center for Statistical Genetics, Department of Biostatistics, University of Michigan, School of Public Health, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2013.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824118PMC
November 2013

Sample size determination for quadratic inference functions in longitudinal design with dichotomous outcomes.

Stat Med 2012 Apr 23;31(8):787-800. Epub 2012 Feb 23.

Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.

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http://doi.wiley.com/10.1002/sim.4458
Publisher Site
http://dx.doi.org/10.1002/sim.4458DOI Listing
April 2012

Fluid overload at initiation of renal replacement therapy is associated with lack of renal recovery in patients with acute kidney injury.

Nephrol Dial Transplant 2012 Mar 19;27(3):956-61. Epub 2011 Aug 19.

Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1093/ndt/gfr470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471547PMC
March 2012