Youhou Kang

Youhou Kang

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Youhou Kang

Youhou Kang

Publications by authors named "Youhou Kang"

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Pancreatitis-Induced Depletion of Syntaxin 2 Promotes Autophagy and Increases Basolateral Exocytosis.

Gastroenterology 2018 05 31;154(6):1805-1821.e5. Epub 2018 Jan 31.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Physiology, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.01.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461447PMC
May 2018

Syntaxin 2 Acts as Inhibitory SNARE for Insulin Granule Exocytosis.

Diabetes 2017 04 23;66(4):948-959. Epub 2017 Jan 23.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada

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http://dx.doi.org/10.2337/db16-0636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860373PMC
April 2017

Munc18b Increases Insulin Granule Fusion, Restoring Deficient Insulin Secretion in Type-2 Diabetes Human and Goto-Kakizaki Rat Islets with Improvement in Glucose Homeostasis.

EBioMedicine 2017 Feb 22;16:262-274. Epub 2017 Jan 22.

Department of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.01.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474508PMC
February 2017

Synaptotagmin-7 Functions to Replenish Insulin Granules for Exocytosis in Human Islet β-Cells.

Diabetes 2016 07 26;65(7):1962-76. Epub 2016 Apr 26.

Department of Medicine, University of Toronto, Toronto, ON, Canada Department of Physiology, University of Toronto, Toronto, ON, Canada

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http://dx.doi.org/10.2337/db15-1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384637PMC
July 2016

Syntaxin-4 mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose-stimulated insulin secretion in human pancreatic beta cells.

Diabetologia 2015 Jun 13;58(6):1250-9. Epub 2015 Mar 13.

Department of Medicine, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, ON, Canada, M5S 1A8.

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http://dx.doi.org/10.1007/s00125-015-3545-4DOI Listing
June 2015

Phosphatidylinositol 4,5-biphosphate (PIP2) modulates syntaxin-1A binding to sulfonylurea receptor 2A to regulate cardiac ATP-sensitive potassium (KATP) channels.

J Mol Cell Cardiol 2014 Oct 26;75:100-10. Epub 2014 Jul 26.

Department of Medicine, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2014.07.012DOI Listing
October 2014

RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding α2 δ-1 subunit.

Traffic 2013 Apr 14;14(4):428-39. Epub 2013 Feb 14.

Department of Physiology and Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1111/tra.12047DOI Listing
April 2013

Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A.

J Mol Cell Cardiol 2011 Nov 22;51(5):790-802. Epub 2011 Aug 22.

Department of Medicine, University of Toronto, Room 7368, Medical Sciences Building, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/j.yjmcc.2011.08.011DOI Listing
November 2011

SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.

Diabetes 2011 Mar 24;60(3):838-47. Epub 2011 Jan 24.

Department of Pharmacology and Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.2337/db10-0440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046844PMC
March 2011

ATP modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic beta-cell KATP channels.

J Biol Chem 2011 Feb 20;286(7):5876-83. Epub 2010 Dec 20.

Department of Medicine, University of Toronto and University Health Network, Toronto, Ontario M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M109.089607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037700PMC
February 2011

Truncation of SNAP-25 reduces the stimulatory action of cAMP on rapid exocytosis in insulin-secreting cells.

Am J Physiol Endocrinol Metab 2009 Aug 9;297(2):E452-61. Epub 2009 Jun 9.

Department of Clinical Sciences Lund, Biomedical Center, Lund University Diabetes Centre, Lund, Sweden.

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http://ajpendo.physiology.org/content/ajpendo/297/2/E452.ful
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http://ajpendo.physiology.org/cgi/doi/10.1152/ajpendo.90585.
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http://dx.doi.org/10.1152/ajpendo.90585.2008DOI Listing
August 2009

Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.

Cardiovasc Res 2008 Dec 14;80(3):365-74. Epub 2008 Aug 14.

Department of Medicine, University of Toronto, Room 7310, Medical Sciences Building, Toronto, ON, Canada.

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http://dx.doi.org/10.1093/cvr/cvn210DOI Listing
December 2008

SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteins.

Endocr Rev 2007 Oct 18;28(6):653-63. Epub 2007 Sep 18.

Departmnet of Physiology, China Medical University, Taichung 40402, Taiwan.

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http://dx.doi.org/10.1210/er.2007-0010DOI Listing
October 2007

The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.

Diabetes 2007 Aug 11;56(8):2124-34. Epub 2007 May 11.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.2337/db07-0030DOI Listing
August 2007

Distinct modulation of Kv1.2 channel gating by wild type, but not open form, of syntaxin-1A.

Am J Physiol Gastrointest Liver Physiol 2007 May 18;292(5):G1233-42. Epub 2007 Jan 18.

Department of Medicine and Physiology, University Health Network, University of Toronto, Toronto, Canada.

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http://www.physiology.org/doi/10.1152/ajpgi.00473.2006
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http://dx.doi.org/10.1152/ajpgi.00473.2006DOI Listing
May 2007

Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells.

Endocrinology 2006 Aug 27;147(8):3727-36. Epub 2006 Apr 27.

Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 67 College Street, Toronto, Ontario, Canada M5G 2M1.

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http://dx.doi.org/10.1210/en.2006-0056DOI Listing
August 2006

The neuronal Ca2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion.

J Biol Chem 2006 Aug 26;281(31):21942-53. Epub 2006 May 26.

Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M512924200
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http://dx.doi.org/10.1074/jbc.M512924200DOI Listing
August 2006

Modulation of Kv2.1 channel gating and TEA sensitivity by distinct domains of SNAP-25.

Biochem J 2006 Jun;396(2):363-9

School of Public Health and Family Medicine, Capital University of Medical Sciences, Beijing, China.

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http://dx.doi.org/10.1042/BJ20051478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462716PMC
June 2006

Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A.

J Biol Chem 2004 Nov 31;279(45):47125-31. Epub 2004 Aug 31.

Department of Medicine, University of Toronto, Toronto M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M404954200DOI Listing
November 2004

Regional differences in L-type Ca2+ channel expression in feline lower esophageal sphincter.

Am J Physiol Gastrointest Liver Physiol 2004 Oct 3;287(4):G772-81. Epub 2004 Jun 3.

Department of Medicine, University of Toronto, Ontario, Canada M5T 2S8.

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http://www.physiology.org/doi/10.1152/ajpgi.00102.2004
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http://dx.doi.org/10.1152/ajpgi.00102.2004DOI Listing
October 2004

Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel.

J Biol Chem 2004 Feb 25;279(6):4234-40. Epub 2003 Nov 25.

Department of Medicine of the University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M309667200
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http://dx.doi.org/10.1074/jbc.M309667200DOI Listing
February 2004

Direct interaction of target SNAREs with the Kv2.1 channel. Modal regulation of channel activation and inactivation gating.

J Biol Chem 2003 Sep 13;278(36):34320-30. Epub 2003 Jun 13.

Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Ramat Aviv, Israel.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304943200
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http://dx.doi.org/10.1074/jbc.M304943200DOI Listing
September 2003

SNAP-25 inhibits L-type Ca2+ channels in feline esophagus smooth muscle cells.

Biochem Biophys Res Commun 2003 Jun;306(1):298-302

University Health Network, Toronto Western Hospital, Ont., M5T 2S8, Toronto, Canada.

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http://dx.doi.org/10.1016/s0006-291x(03)00968-9DOI Listing
June 2003

Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking.

J Biol Chem 2003 May 5;278(19):17532-8. Epub 2003 Mar 5.

Department of Medicine, University of Toronto, Toronto M5S 1A8, Canada.

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http://dx.doi.org/10.1074/jbc.M213088200DOI Listing
May 2003

Effects of selective endocrine or exocrine induction of AR42J on SNARE and Munc18 protein expression.

Pancreas 2002 Nov;25(4):e56-63

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

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November 2002