Yoshiro Saito

Yoshiro Saito

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Overall Similarities and a Possible Factor Affecting Plasma Metabolome Profiles Between Venous and Capillary Blood Samples From 20 Healthy Human Males.

J Pharm Sci 2019 Nov 5;108(11):3737-3744. Epub 2019 Sep 5.

Division of Medical Safety Science, National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2019.08.026DOI Listing
November 2019

Evaluating the impact of regulatory action on denosumab-induced hypocalcaemia in Japan.

J Clin Pharm Ther 2019 Oct 7;44(5):788-795. Epub 2019 Jul 7.

Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki, Japan.

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http://dx.doi.org/10.1111/jcpt.13004DOI Listing
October 2019

Serum lipidomics for exploring biomarkers of bortezomib therapy in patients with multiple myeloma.

Cancer Sci 2019 Oct 19;110(10):3267-3274. Epub 2019 Sep 19.

Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1111/cas.14178DOI Listing
October 2019

Application of Ion Chromatography Coupled with Mass Spectrometry for Human Serum and Urine Metabolomics.

SLAS Discov 2019 Aug 5;24(7):778-786. Epub 2019 Jun 5.

1 Division of Medical Safety Science, National Institute of Health Sciences, Kanagawa, Japan.

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http://dx.doi.org/10.1177/2472555219850082DOI Listing
August 2019

Selenoprotein P as a significant regulator of pancreatic β cell function.

Authors:
Yoshiro Saito

J Biochem 2019 Aug 2. Epub 2019 Aug 2.

Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan.

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http://dx.doi.org/10.1093/jb/mvz061DOI Listing
August 2019

Polymerization of Oxidized DJ-1 via Noncovalent and Covalent Binding: Significance of Disulfide Bond Formation.

ACS Omega 2019 Jun 3;4(6):9603-9614. Epub 2019 Jun 3.

The Systems Life Sciences Laboratory, Department of Life and Medical Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto 610-0394, Japan.

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http://dx.doi.org/10.1021/acsomega.9b00324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648325PMC
June 2019

Comprehensive lipid profiling of bleomycin-induced lung injury.

J Appl Toxicol 2019 Apr 18;39(4):658-671. Epub 2018 Dec 18.

Department of Respirology (B2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba, Japan.

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http://dx.doi.org/10.1002/jat.3758DOI Listing
April 2019

Conference report: pharmacogenomics in special populations at WCP2018.

Br J Clin Pharmacol 2019 03 24;85(3):467-475. Epub 2019 Jan 24.

Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, Australia.

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http://dx.doi.org/10.1111/bcp.13828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379283PMC
March 2019

Identification of risk factors and development of detection algorithm for denosumab-induced hypocalcaemia.

J Clin Pharm Ther 2019 Feb 24;44(1):62-68. Epub 2018 Aug 24.

Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki, Japan.

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http://doi.wiley.com/10.1111/jcpt.12753
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http://dx.doi.org/10.1111/jcpt.12753DOI Listing
February 2019

[Current Status of Health Foods Including Their Interactions with Drugs and Adverse Events].

Authors:
Yoshiro Saito

Yakugaku Zasshi 2018 ;138(12):1511-1516

Division of Medicinal Safety Science, National Institute of Health Sciences.

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https://www.jstage.jst.go.jp/article/yakushi/138/12/138_18-0
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http://dx.doi.org/10.1248/yakushi.18-00155-1DOI Listing
February 2019

Response by Kikuchi et al Regarding Article, "Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target".

Circulation 2019 Jan;139(5):724-725

Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (N.K., K.S., H.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038479DOI Listing
January 2019

Low Levels of Amlodipine in Breast Milk and Plasma.

Breastfeed Med 2018 11 28;13(9):622-626. Epub 2018 Sep 28.

8 Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children , Toronto, Ontario, Canada .

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http://dx.doi.org/10.1089/bfm.2018.0158DOI Listing
November 2018

2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays).

Bioanalysis 2018 Nov 29. Epub 2018 Nov 29.

Amador Bioscience, Pleasanton, CA, USA (formerly of OncoMed, Redwood City, CA, USA).

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http://dx.doi.org/10.4155/bio-2018-0287DOI Listing
November 2018

Lipid profiling of pre-treatment plasma reveals biomarker candidates associated with response rates and hand-foot skin reactions in sorafenib-treated patients.

Cancer Chemother Pharmacol 2018 10 30;82(4):677-684. Epub 2018 Jul 30.

Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00280-018-3655-zDOI Listing
October 2018

Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.

Biochimie 2018 Oct 7;153:203-209. Epub 2018 Jul 7.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2018.07.004DOI Listing
October 2018

Hydrogen Peroxide-Reducing Factor Released by PC12D Cells Increases Cell Tolerance against Oxidative Stress.

Biol Pharm Bull 2018 ;41(5):777-785

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University.

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http://dx.doi.org/10.1248/bpb.b18-00016DOI Listing
September 2018

Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits.

Biol Pharm Bull 2018 ;41(5):828-832

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University.

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http://dx.doi.org/10.1248/bpb.b18-00046DOI Listing
September 2018

Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension.

Circulation 2018 08;138(6):600-623

Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (N.K., K.S., R.K., S.M., N.Y., M.E.-A.-M., M.A.H.S., J.O., T.S., M.N., S.S., H.S.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.033113DOI Listing
August 2018

Association between dipeptidyl peptidase-4 inhibitors and urinary tract infection in elderly patients: A retrospective cohort study.

Pharmacoepidemiol Drug Saf 2018 08 30;27(8):931-939. Epub 2018 May 30.

Department of Health Care Administration and Management, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka City, Japan.

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http://dx.doi.org/10.1002/pds.4560DOI Listing
August 2018

Ether-phosphatidylcholine characterized by consolidated plasma and liver lipidomics is a predictive biomarker for valproic acid-induced hepatic steatosis.

J Toxicol Sci 2018 ;43(6):395-405

Toxicology Research Lab., Central Pharmaceutical Research Institute, JAPAN TOBACCO Inc.

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http://dx.doi.org/10.2131/jts.43.395DOI Listing
August 2018

Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.

Sci Rep 2018 08 13;8(1):12056. Epub 2018 Aug 13.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, 610-0394, Japan.

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http://dx.doi.org/10.1038/s41598-018-30561-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089991PMC
August 2018

6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.

Autophagy 2018 16;14(11):1943-1958. Epub 2018 Aug 16.

a Department of Medical Life Systems, Faculty of Life and Medical Sciences , Doshisha University , Kyoto , Japan.

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http://dx.doi.org/10.1080/15548627.2018.1493043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152502PMC
August 2018

Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies.

J Pharmacol Sci 2018 Aug 9;137(4):350-358. Epub 2018 Aug 9.

Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, Japan; Department of Pharmacology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13478613183012
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http://dx.doi.org/10.1016/j.jphs.2018.06.013DOI Listing
August 2018

Points-to-consider documents: Scientific information on the evaluation of genetic polymorphisms during non-clinical studies and phase I clinical trials in the Japanese population.

Drug Metab Pharmacokinet 2018 Jun 15;33(3):141-149. Epub 2018 Mar 15.

Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan; National Institute of Health Sciences (NIHS), Tokyo, Japan.

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http://dx.doi.org/10.1016/j.dmpk.2018.01.005DOI Listing
June 2018

Current situation on biomarker validation in Japan.

Bioanalysis 2018 06 20;10(12):901-903. Epub 2018 Jun 20.

Analysis & Pharmacokinetics Research Laboratories, Astellas Pharma, Inc., Tsukuba, Japan.

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http://dx.doi.org/10.4155/bio-2017-0244DOI Listing
June 2018

Effect of Infectious Diseases on the Pathogenesis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Biol Pharm Bull 2017 ;40(9):1576-1580

Division of Medicinal Safety Science, National Institute of Health Sciences.

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http://dx.doi.org/10.1248/bpb.b17-00207DOI Listing
May 2018

DJ-1 as a Biomarker of Parkinson's Disease.

Authors:
Yoshiro Saito

Adv Exp Med Biol 2017 ;1037:149-171

Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto, 610-0394, Japan.

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http://dx.doi.org/10.1007/978-981-10-6583-5_10DOI Listing
April 2018

Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein.

Neurosci Res 2018 Mar 10;128:58-62. Epub 2017 Jul 10.

Department of Neurology, Faculty of Medicine, Kindai University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan.

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http://dx.doi.org/10.1016/j.neures.2017.06.008DOI Listing
March 2018

Comparison of different immunoassay methods to detect human anti-drug antibody using the WHO erythropoietin antibody reference panel for analytes.

J Immunol Methods 2018 01 29;452:73-77. Epub 2017 Sep 29.

National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jim.2017.09.009DOI Listing
January 2018

Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.

Genes Cells 2018 Jan 5;23(1):22-34. Epub 2017 Dec 5.

Department of Molecular Life Sciences, Graduate School of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto, Japan.

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http://dx.doi.org/10.1111/gtc.12544DOI Listing
January 2018

Immunogenicity of therapeutic protein products: current considerations for anti-drug antibody assay in Japan.

Bioanalysis 2018 Jan 15;10(2):95-105. Epub 2017 Dec 15.

National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501, Japan.

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http://dx.doi.org/10.4155/bio-2017-0186DOI Listing
January 2018

Association between infection and severe drug adverse reactions: an analysis using data from the Japanese Adverse Drug Event Report database.

Eur J Clin Pharmacol 2017 Dec 22;73(12):1643-1653. Epub 2017 Aug 22.

Division of Medicinal Safety Science, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo, 158-8501, Japan.

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http://dx.doi.org/10.1007/s00228-017-2320-5DOI Listing
December 2017

Pharmacokinetics and Pharmacodynamics of Meloxicam in East Asian Populations: The Role of Ethnicity on Drug Response.

CPT Pharmacometrics Syst Pharmacol 2017 12 23;6(12):823-832. Epub 2017 Nov 23.

Laboratory of Clinical Pharmacokinetics, School of Pharmacy, Nihon University, Chiba, Japan.

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http://dx.doi.org/10.1002/psp4.12259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5744175PMC
December 2017

Structural Basis of Single-Nucleotide Polymorphisms in Cytochrome P450 2C9.

Biochemistry 2017 10 3;56(41):5476-5480. Epub 2017 Oct 3.

Department of Pharmaceutical Sciences, University of Connecticut , Storrs, Connecticut 06267, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5761073PMC
October 2017

Plasma Lipidomics of Healthy Japanese Adults Reveals Gender- and Age-Related Differences.

J Pharm Sci 2017 09 8;106(9):2914-2918. Epub 2017 May 8.

Division of Medicinal Safety Science, National Institute of Health Sciences, Setagaya, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.05.002DOI Listing
September 2017

Arachidonic acid-containing phosphatidylcholine characterized by consolidated plasma and liver lipidomics as an early onset marker for tamoxifen-induced hepatic phospholipidosis.

J Appl Toxicol 2017 08 31;37(8):943-953. Epub 2017 Jan 31.

Toxicology Research Lab, Central Pharmaceutical Research Institute, Japan Tobacco Inc., Hadano, Kanagawa, 257-0024, Japan.

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http://doi.wiley.com/10.1002/jat.3442
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http://dx.doi.org/10.1002/jat.3442DOI Listing
August 2017

Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum.

PLoS One 2016 2;11(8):e0160530. Epub 2016 Aug 2.

Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160530PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4970716PMC
July 2017

Cross-Classification of Human Urinary Lipidome by Sex, Age, and Body Mass Index.

PLoS One 2016 14;11(12):e0168188. Epub 2016 Dec 14.

Division of Medicinal Safety Science, National Institute of Health Sciences, Setagaya, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168188PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156423PMC
July 2017

Enrichment of resolving power improves ion-peak quantification on a lipidomics platform.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Jun 13;1055-1056:20-28. Epub 2017 Apr 13.

Division of Medical Safety Science, National Institute of Health Sciences, Setagaya, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.jchromb.2017.04.019DOI Listing
June 2017

Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis.

J Steroid Biochem Mol Biol 2017 05 4;169:69-76. Epub 2016 Mar 4.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jsbmb.2016.03.003DOI Listing
May 2017

Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47.

Sci Rep 2017 02 27;7:43441. Epub 2017 Feb 27.

Laboratory of Human Retrovirology and Immunoinformatics, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, USA.

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http://dx.doi.org/10.1038/srep43441DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5327488PMC
February 2017

Gender- and Age-Associated Differences in Serum Metabolite Profiles among Japanese Populations.

Biol Pharm Bull 2016 ;39(7):1179-86

Division of Medicinal Safety Science, National Institute of Health Sciences.

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http://dx.doi.org/10.1248/bpb.b16-00226DOI Listing
January 2017

[Regulatory science on biomarker usage for development and proper use of drugs].

Yakugaku Zasshi 2015 ;135(5):647-8

National Institute of Health Sciences, Division of Medicinal Safety Science.

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http://dx.doi.org/10.1248/yakushi.14-00230-FDOI Listing
September 2016

[Regulatory science for the proper evaluation of biomarkers (overview)].

Yakugaku Zasshi 2015 ;135(5):649-53

Department of Regulatory Science, Graduate School of Pharmaceutical Sciences, Nagoya City University.

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http://dx.doi.org/10.1248/yakushi.14-00230-1DOI Listing
September 2016

[Predictive genomic markers for severe adverse drug reactions].

Yakugaku Zasshi 2015 ;135(4):589-95

Division of Medicinal Safety Science, National Institute of Health Sciences.

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http://dx.doi.org/10.1248/yakushi.14-00249-3DOI Listing
June 2016

Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma.

Sci Rep 2016 06 30;6:28932. Epub 2016 Jun 30.

Division of Medical Safety Science, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo, Japan.

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http://dx.doi.org/10.1038/srep28932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928052PMC
June 2016

Plasma lipid profiling of different types of hepatic fibrosis induced by carbon tetrachloride and lomustine in rats.

Lipids Health Dis 2016 Apr 12;15:74. Epub 2016 Apr 12.

Division of Medical Safety Science, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo, 158-8501, Japan.

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http://dx.doi.org/10.1186/s12944-016-0244-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828842PMC
April 2016

Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum.

J Clin Lab Anal 2016 Mar 26;30(2):114-22. Epub 2014 Dec 26.

Diagnostic R&D, Development & Production Headquarters, Alfresa Pharma Corporation, Ibaraki City, Osaka, Japan.

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http://dx.doi.org/10.1002/jcla.21824DOI Listing
March 2016

Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene.

J Lipid Res 2015 Nov 27;56(11):2172-82. Epub 2015 Sep 27.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M059105
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http://dx.doi.org/10.1194/jlr.M059105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617404PMC
November 2015

New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death.

Free Radic Biol Med 2015 Oct 9;87:366-72. Epub 2015 Jul 9.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan.

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http://dx.doi.org/10.1016/j.freeradbiomed.2015.06.036DOI Listing
October 2015

Comparison of circulating lipid profiles between fasting humans and three animal species used in preclinical studies: mice, rats and rabbits.

Lipids Health Dis 2015 Sep 10;14:104. Epub 2015 Sep 10.

Division of Medicinal Safety Science, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya, Tokyo, 158-8501, Japan.

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http://dx.doi.org/10.1186/s12944-015-0104-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566205PMC
September 2015

Association of aging with gene expression profiling in mouse submandibular glands.

Genom Data 2015 Sep 30;5:115-9. Epub 2015 May 30.

Department of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan.

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http://dx.doi.org/10.1016/j.gdata.2015.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584023PMC
September 2015

24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8.

Steroids 2015 Jul 16;99(Pt B):230-7. Epub 2015 Feb 16.

Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, 1-3 Miyakodani, Tatara, Kyotanabe, Kyoto 610-0394, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.steroids.2015.02.007DOI Listing
July 2015

Impact of Japanese regulatory action on metformin-associated lactic acidosis in type II diabetes patients.

Int J Clin Pharm 2015 Jun 31;37(3):537-45. Epub 2015 Mar 31.

Division of Medicinal Safety Science, National Institute of Health Sciences, Kamiyoga 1-18-1, Setagaya-ku, Tokyo, 158-8501, Japan.

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http://dx.doi.org/10.1007/s11096-015-0097-0DOI Listing
June 2015

No contribution of the ABCB11 p.444A polymorphism in Japanese patients with drug-induced cholestasis.

Drug Metab Dispos 2015 May 23;43(5):691-7. Epub 2015 Feb 23.

Department of Gastroenterology (T.K., S.H., Y.A., K.A., K.T., K.S., R.O., S.I., T.M.), Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine (H.I.), and Institute of Medical Science (A.O.), Tokai University School of Medicine, Isehara, Japan; Department of Gastroenterology, Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan (T.N.); Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan (K.T., R.H., S.M.); Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan (H.E., H.S.); Department of Gastroenterology, Juntendo University Urayasu Hospital, Urayasu, Japan (T.K.); International University of Health and Welfare, Research Centre of Clinical Medicine, Sanno Hospital, Tokyo, Japan (Y.H.); Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan (C.O.); Ikegami General Hospital, Tokyo, Japan (M.W.); Division of Medicinal Safety Science, National Institutes of Health Sciences, Tokyo, Japan (M.T., Y.S., K.M.); and Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan (H.T.).

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http://dx.doi.org/10.1124/dmd.114.061325DOI Listing
May 2015

[Collaborative projects with academia for regulatory science studies on biomarkers].

Kokuritsu Iyakuhin Shokuhin Eisei Kenkyusho Hokoku 2014 (132):19-21

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March 2015

Hydrocortisone enhances the barrier properties of HBMEC/ciβ, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects.

Fluids Barriers CNS 2015 5;12. Epub 2015 Mar 5.

Laboratory of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba-shi, Chiba 260-8675 Japan.

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http://www.fluidsbarrierscns.com/content/12/1/7
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http://dx.doi.org/10.1186/s12987-015-0003-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4355132PMC
March 2015

The risk of cutaneous adverse reactions among patients with the HLA-A* 31:01 allele who are given carbamazepine, oxcarbazepine or eslicarbazepine: a perspective review.

Ther Adv Drug Saf 2013 Dec;4(6):246-53

Director, Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan.

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http://dx.doi.org/10.1177/2042098613499791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125310PMC
December 2013