Yoshio Hirabayashi

Yoshio Hirabayashi

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Yoshio Hirabayashi

Publications by authors named "Yoshio Hirabayashi"

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Roles of GPRC5 family proteins: focusing on GPRC5B and lipid-mediated signalling.

J Biochem 2020 Jun;167(6):541-547

Department of Biochemistry, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409-3898, Japan.

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http://dx.doi.org/10.1093/jb/mvaa030DOI Listing
June 2020

Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia.

Schizophr Bull 2020 Apr 29. Epub 2020 Apr 29.

Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Saitama, Japan.

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http://dx.doi.org/10.1093/schbul/sbaa052DOI Listing
April 2020

Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals.

FASEB J 2020 Jan 2;34(1):1465-1480. Epub 2019 Dec 2.

Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Center for Brain Science, Wako-shi, Japan.

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http://dx.doi.org/10.1096/fj.201901598RDOI Listing
January 2020

Kras promotes myeloid differentiation through Wnt/β-catenin signaling.

FASEB Bioadv 2019 Jul 1;1(7):435-449. Epub 2019 Jul 1.

Institute for Environmental and Gender Specific Medicine Juntendo University Graduate School of Medicine Urayasu Chiba Japan.

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http://dx.doi.org/10.1096/fba.2019-00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996383PMC
July 2019

Loss of GPRC5B impairs synapse formation of Purkinje cells with cerebellar nuclear neurons and disrupts cerebellar synaptic plasticity and motor learning.

Neurosci Res 2018 Nov 23;136:33-47. Epub 2018 Feb 23.

Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neures.2018.02.006DOI Listing
November 2018

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Cell Metab 2018 10 12;28(4):573-587.e13. Epub 2018 Jul 12.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.009DOI Listing
October 2018

GPRC5B-Mediated Sphingomyelin Synthase 2 Phosphorylation Plays a Critical Role in Insulin Resistance.

iScience 2018 Oct 6;8:250-266. Epub 2018 Oct 6.

Cell Informatics Laboratory, RIKEN, Wako-shi, Saitama 351-0198, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S25890042183016
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http://dx.doi.org/10.1016/j.isci.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197706PMC
October 2018

Caveolin-1 prevents palmitate-induced NF-κB signaling by inhibiting GPRC5B-phosphorylation.

Biochem Biophys Res Commun 2018 09 4;503(4):2673-2677. Epub 2018 Aug 4.

Cell Informatics Laboratory, RIKEN, Wako-shi, Saitama, 351-0198, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183169
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http://dx.doi.org/10.1016/j.bbrc.2018.08.022DOI Listing
September 2018

Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced obese mice.

Biochem Biophys Res Commun 2018 09 1;504(1):309-314. Epub 2018 Sep 1.

Department of Metabolism and Nutrition, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, 930-0194, Japan; Institute of Natural Medicine, University of Toyama, Toyama, 930-0194, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183188
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http://dx.doi.org/10.1016/j.bbrc.2018.08.180DOI Listing
September 2018

Squaryl group modified phosphoglycolipid analogs as potential modulators of GPR55.

Chem Commun (Camb) 2018 Jul;54(61):8470-8473

Synthetic Cellular Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1039/c8cc04467hDOI Listing
July 2018

EPT1 (selenoprotein I) is critical for the neural development and maintenance of plasmalogen in humans.

J Lipid Res 2018 06 2;59(6):1015-1026. Epub 2018 Mar 2.

Department of Biochemistry, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan

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http://dx.doi.org/10.1194/jlr.P081620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5983406PMC
June 2018

Regulation of glucosylceramide synthesis by Golgi-localized phosphoinositide.

Biochem Biophys Res Commun 2018 05 11;499(4):1011-1018. Epub 2018 Apr 11.

Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama, 351-0198, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2018.04.039DOI Listing
May 2018

Identifying the localization and exploring a functional role for Gprc5c in the kidney.

FASEB J 2018 04 5;32(4):2046-2059. Epub 2018 Jan 5.

Department of Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1096/fj.201700610RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893170PMC
April 2018

Identification and characterization of UDP-mannose in human cell lines and mouse organs: Differential distribution across brain regions and organs.

Biochem Biophys Res Commun 2018 01 11;495(1):401-407. Epub 2017 Nov 11.

Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, RIKEN Global Research Cluster, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.10.173DOI Listing
January 2018

A novel function for glucocerebrosidase as a regulator of sterylglucoside metabolism.

Biochim Biophys Acta Gen Subj 2017 Oct 6;1861(10):2507-2514. Epub 2017 Jun 6.

Laboratory for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.06.003DOI Listing
October 2017

Loss of BOSS Causes Shortened Lifespan with Mitochondrial Dysfunction in Drosophila.

PLoS One 2017 3;12(1):e0169073. Epub 2017 Jan 3.

Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Wako-shi, Saitama, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0169073PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207625PMC
September 2017

WP1066, a small molecule inhibitor of the JAK/STAT3 pathway, inhibits ceramide glucosyltransferase activity.

Biochem Biophys Res Commun 2017 09 21;491(2):265-270. Epub 2017 Jul 21.

Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.07.115DOI Listing
September 2017

Aglycon diversity of brain sterylglucosides: structure determination of cholesteryl- and sitosterylglucoside.

J Lipid Res 2016 11 3;57(11):2061-2072. Epub 2016 Oct 3.

Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan

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http://dx.doi.org/10.1194/jlr.M071480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087873PMC
November 2016

Separation and analysis of mono-glucosylated lipids in brain and skin by hydrophilic interaction chromatography based on carbohydrate and lipid moiety.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Sep 26;1031:146-153. Epub 2016 Jul 26.

Molecular Membrane Neuroscience, RIKEN Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2016.07.047DOI Listing
September 2016

Differential Effects of Tissue-Specific Deletion of BOSS on Feeding Behaviors and Energy Metabolism.

PLoS One 2015 20;10(7):e0133083. Epub 2015 Jul 20.

Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Wako-shi, Saitama, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133083PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508045PMC
April 2016

Adaptive response to l-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts.

FEBS Open Bio 2016 04 3;6(4):303-16. Epub 2016 Mar 3.

Laboratory of Functional Genomics and Metabolism Department of Innovative Science and Technology for Bio-industry Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Fukuoka Japan; Department of Bioscience and Biotechnology Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Fukuoka Japan; Department of Genetic Resources Technology Graduate School of Bioresource and Bioenvironmental Sciences Kyushu University Fukuoka Japan.

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http://dx.doi.org/10.1002/2211-5463.12038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821351PMC
April 2016

Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant α-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease.

Hum Mol Genet 2015 Dec 11;24(23):6675-86. Epub 2015 Sep 11.

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan and

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http://hmg.oxfordjournals.org/content/early/2015/09/11/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv372DOI Listing
December 2015

Evaluation of aegerolysins as novel tools to detect and visualize ceramide phosphoethanolamine, a major sphingolipid in invertebrates.

FASEB J 2015 Sep 9;29(9):3920-34. Epub 2015 Jun 9.

*Lipid Biology Laboratory, RIKEN, and Laboratory of Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Saitama, Japan; Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan; Yukiguni Maitake Co. Ltd., Niigata, Japan; Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan; Graduate School of Life and Environmental Sciences and Faculty of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan; **Department of Environmental Science and Education, Faculty of Human Life Science, Tokyo Kasei University, Tokyo, Japan; and Institut National de la Santé et de la Recherche Médicale Unité 1060, Université Lyon 1, Villeurbanne, France

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http://www.fasebj.org/doi/10.1096/fj.15-272112
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http://dx.doi.org/10.1096/fj.15-272112DOI Listing
September 2015

AMP-activated Protein Kinase Suppresses Biosynthesis of Glucosylceramide by Reducing Intracellular Sugar Nucleotides.

J Biol Chem 2015 Jul 5;290(29):18245-60. Epub 2015 Jun 5.

From the Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan

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http://dx.doi.org/10.1074/jbc.M115.658948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505067PMC
July 2015

L-Serine Deficiency Elicits Intracellular Accumulation of Cytotoxic Deoxysphingolipids and Lipid Body Formation.

J Biol Chem 2015 Jun 22;290(23):14595-609. Epub 2015 Apr 22.

From the Laboratories of Functional Genomics and Metabolism and Bio-Architecture Center, Kyushu University, Fukuoka 812-8581,

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http://dx.doi.org/10.1074/jbc.M114.603860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505526PMC
June 2015

Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy.

J Neurochem 2014 Dec 21;131(5):675-87. Epub 2014 Aug 21.

Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto, Japan.

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http://dx.doi.org/10.1111/jnc.12838DOI Listing
December 2014

[Novel functions of brain lipids modified with glucose].

Seikagaku 2014 Dec;86(6):735-43

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December 2014

Ceramide galactosyltransferase expression is regulated positively by Nkx2.2 and negatively by OLIG2.

Glycobiology 2014 Oct 11;24(10):926-34. Epub 2014 May 11.

Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, Global Research Cluster, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan

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http://dx.doi.org/10.1093/glycob/cwu042DOI Listing
October 2014

Infusion of growth hormone into the hippocampus induces molecular and behavioral responses in mice.

Exp Brain Res 2014 Sep 18;232(9):2957-66. Epub 2014 May 18.

Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto, 603-8555, Japan.

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http://dx.doi.org/10.1007/s00221-014-3977-yDOI Listing
September 2014

Synthesis of o-linked glycoconjugates in the nervous system.

Adv Neurobiol 2014;9:71-87

Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai, Miyagi, 981-8558, Japan.

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http://dx.doi.org/10.1007/978-1-4939-1154-7_4DOI Listing
January 2014

Cholesterol glucosylation is catalyzed by transglucosylation reaction of β-glucosidase 1.

Biochem Biophys Res Commun 2013 Nov 6;441(4):838-43. Epub 2013 Nov 6.

Graduate School of Humanities and Sciences, Department of Life Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610, Japan; Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.10.145DOI Listing
November 2013

The acetyl-CoA transporter family SLC33.

Mol Aspects Med 2013 Apr-Jun;34(2-3):586-9

Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.mam.2012.05.009DOI Listing
September 2013

New insights on glucosylated lipids: metabolism and functions.

Biochim Biophys Acta 2013 Sep 13;1831(9):1475-85. Epub 2013 Jun 13.

Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Wako, Saitama, Japan.

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http://dx.doi.org/10.1016/j.bbalip.2013.06.001DOI Listing
September 2013

A bilirubin-inducible fluorescent protein from eel muscle.

Cell 2013 Jun 13;153(7):1602-11. Epub 2013 Jun 13.

Cell Function Dynamics, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.cell.2013.05.038DOI Listing
June 2013

Brain gangliosides of a transgenic mouse model of Alzheimer's disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1aα.

ASN Neuro 2013 May 30;5(2):141-8. Epub 2013 May 30.

Institute of Molecular Medicine and Genetics and Institute of Neuroscience, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912, USA.

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http://dx.doi.org/10.1042/AN20130006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667643PMC
May 2013

A small molecule inhibitor of Bcl-2, HA14-1, also inhibits ceramide glucosyltransferase.

Biochem Biophys Res Commun 2013 Apr 26;433(2):170-4. Epub 2013 Feb 26.

Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi, Niigata 956-8603, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2013.02.052DOI Listing
April 2013

GPRC5B activates obesity-associated inflammatory signaling in adipocytes.

Sci Signal 2012 Nov 20;5(251):ra85. Epub 2012 Nov 20.

Laboratory for Molecular Membrane Neuroscience, RIKEN Brain Science Institute, Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2003149
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http://dx.doi.org/10.1126/scisignal.2003149DOI Listing
November 2012

A world of sphingolipids and glycolipids in the brain--novel functions of simple lipids modified with glucose.

Proc Jpn Acad Ser B Phys Biol Sci 2012 ;88(4):129-43

Laboratory for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Saitama, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406307PMC
http://dx.doi.org/10.2183/pjab.88.129DOI Listing
September 2012

Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis.

FASEB J 2012 Jul 16;26(7):3065-74. Epub 2012 Apr 16.

Department of Neurology, Fujita Health University School of Medicine, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi 470-1192, Japan.

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http://www.fasebj.org/content/26/7/3065.full.pdf
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http://www.fasebj.org/cgi/doi/10.1096/fj.11-198630
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http://dx.doi.org/10.1096/fj.11-198630DOI Listing
July 2012

Gangliosides stimulate bradykinin B2 receptors to promote calmodulin kinase II-mediated neuronal differentiation.

J Biochem 2012 Jul 9;152(1):63-72. Epub 2012 May 9.

Division of Glyco-Signal Research, Institute of Molecular Biomembrane and Glycobiology, Tohoku Pharmaceutical University, Sendai, Miyagi 981-8558, Japan.

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https://academic.oup.com/jb/article-lookup/doi/10.1093/jb/mv
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http://dx.doi.org/10.1093/jb/mvs055DOI Listing
July 2012

Phosphatidylglucoside: its structure, thermal behavior, and domain formation in plasma membranes.

Chem Phys Lipids 2012 Feb 27;165(2):197-206. Epub 2011 Dec 27.

Biophysics Laboratory, Department of Chemistry and Chemical Biology, Gunma University, Maebashi, Gunm, Japan.

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http://dx.doi.org/10.1016/j.chemphyslip.2011.12.010DOI Listing
February 2012

Up-regulation of ceramide glucosyltransferase during the differentiation of U937 cells.

J Biochem 2011 Sep 10;150(3):303-10. Epub 2011 May 10.

Laboratory for Animal Cell Engineering, Niigata University of Pharmacy and Applied Life Sciences (NUPALS), 265-1 Higashijima, Akiha-ku, Niigata-shi Niigata 956-8603, Japan.

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http://dx.doi.org/10.1093/jb/mvr058DOI Listing
September 2011

Comparative characterization of GPRC5B and GPRC5CLacZ knockin mice; behavioral abnormalities in GPRC5B-deficient mice.

Biochem Biophys Res Commun 2011 Sep 5;412(3):460-5. Epub 2011 Aug 5.

Laboratory for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2011.07.118DOI Listing
September 2011

Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila.

J Lipid Res 2011 Jul 5;52(7):1392-9. Epub 2011 May 5.

Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1194/jlr.M014266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122912PMC
July 2011

Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ).

J Lipid Res 2011 Jun 12;52(6):1294-302. Epub 2011 Apr 12.

Lipid Biology Laboratory, Advanced Science Institute, Brain Science Institute, RIKEN, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1194/jlr.D014621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3090250PMC
June 2011

Canopy1, a positive feedback regulator of FGF signaling, controls progenitor cell clustering during Kupffer's vesicle organogenesis.

Proc Natl Acad Sci U S A 2011 Jun 31;108(24):9881-6. Epub 2011 May 31.

Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Nara 630-0101, Japan.

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http://dx.doi.org/10.1073/pnas.1017248108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116425PMC
June 2011

Novel sterol glucosyltransferase in the animal tissue and cultured cells: evidence that glucosylceramide as glucose donor.

Biochim Biophys Acta 2011 May 17;1811(5):314-22. Epub 2011 Mar 17.

Graduate School of Humanities and Sciences, Department of Life Science, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo 112-8610, Japan.

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http://dx.doi.org/10.1016/j.bbalip.2011.02.005DOI Listing
May 2011

The novel neutrophil differentiation marker phosphatidylglucoside mediates neutrophil apoptosis.

J Immunol 2011 May 30;186(9):5323-32. Epub 2011 Mar 30.

Institute for Environmental and Gender-Specific Medicine, Juntendo University School of Medicine, Urayasu-shi, 279-0021 Chiba, Japan.

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http://dx.doi.org/10.4049/jimmunol.1002100DOI Listing
May 2011

Phosphatidylglucoside: a novel marker for adult neural stem cells.

J Neurochem 2011 Mar 13;116(5):840-4. Epub 2011 Jan 13.

Laboratory for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Wako-shi, Saitama, Japan.

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http://doi.wiley.com/10.1111/j.1471-4159.2010.07106.x
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http://dx.doi.org/10.1111/j.1471-4159.2010.07106.xDOI Listing
March 2011

The Drosophila 7-pass transmembrane glycoprotein BOSS and metabolic regulation: What Drosophila can teach us about human energy metabolism.

Methods Enzymol 2010 ;480:525-38

Laboratory for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Japan.

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http://dx.doi.org/10.1016/S0076-6879(10)80024-2DOI Listing
December 2010

Glycosphingolipid synthesis in cerebellar Purkinje neurons: roles in myelin formation and axonal homeostasis.

Glia 2010 Aug;58(10):1197-207

Laboratory for Molecular Membrane Neuroscience, Brain Science Institute, RIKEN, Wako-Shi, Saitama, Japan.

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http://dx.doi.org/10.1002/glia.20999DOI Listing
August 2010

Improved method of phosphopeptides enrichment using biphasic phosphate-binding tag/C18 tip for versatile analysis of phosphorylation dynamics.

Proteomics 2009 Dec;9(24):5525-33

Hirabayashi Research Unit, Brain Science Institute, RIKEN, Hirosawa, Wako, Saitama, Japan.

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http://dx.doi.org/10.1002/pmic.200900341DOI Listing
December 2009

Analysis of development of lesions in mice with serine palmitoyltransferase (SPT) deficiency -Sptlc2 conditional knockout mice-.

Exp Anim 2009 Oct;58(5):515-24

Safety Assessment, Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan.

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http://dx.doi.org/10.1538/expanim.58.515DOI Listing
October 2009

Simultaneous quantification of glucosylceramide and galactosylceramide by normal-phase HPLC using O-phtalaldehyde derivatives prepared with sphingolipid ceramide N-deacylase.

Glycobiology 2009 Jul 1;19(7):767-75. Epub 2009 May 1.

Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.

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http://dx.doi.org/10.1093/glycob/cwp047DOI Listing
July 2009

Distinct role of growth hormone on epilepsy progression in a model of temporal lobe epilepsy.

J Neurochem 2009 Jul 29;110(2):509-19. Epub 2009 Apr 29.

Department of Structural and Functional Biosciences for Animals, Osaka Prefecture University, Izumisano, Japan.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06132.xDOI Listing
July 2009

Preferential expression of phosphatidylglucoside along neutrophil differentiation pathway.

Leuk Lymphoma 2009 Jul;50(7):1190-7

Division of Cell Transplantation and Transfusion, Jichi Medical University, Tochigi, Shimotsuke, Japan.

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http://dx.doi.org/10.1080/10428190902934928DOI Listing
July 2009

Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model.

Neurosci Res 2009 Mar 11;63(3):184-93. Epub 2008 Dec 11.

Laboratory of Metabolic Regulation Research, Kyushu University Bio-Architecture Center, Fukuoka 812-8581, Japan; Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan.

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http://dx.doi.org/10.1016/j.neures.2008.12.002DOI Listing
March 2009

Glycosphingolipid deficiency increases the sterol regulatory element-mediated gene transcription.

Biochem Biophys Res Commun 2009 Jan 17;378(2):240-3. Epub 2008 Nov 17.

Lipid Biology Laboratory, RIKEN (Institute of Physical and Chemical Research) Advanced Science Institute, 2-1, Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2008.11.030DOI Listing
January 2009

A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism.

Proc Natl Acad Sci U S A 2008 Oct 1;105(40):15328-33. Epub 2008 Oct 1.

Hirabayashi Research Unit, Chemical Neuroscience Group, Brain Science Institute, RIKEN, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1073/pnas.0807833105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563099PMC
October 2008

Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency.

Funct Integr Genomics 2008 Aug 29;8(3):235-49. Epub 2008 Jan 29.

Laboratory of Metabolic Regulation Research, Kyushu University Bio-Architecture Center, Hakozaki, Fukuoka City, Fukuoka, Japan.

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http://dx.doi.org/10.1007/s10142-007-0072-5DOI Listing
August 2008

Increase of GQ1b in the hippocampus of mice following kindled-seizures.

Neurosci Lett 2008 Aug 26;441(3):286-90. Epub 2008 Jun 26.

Department of Structural and Functional Biosciences for Animals, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8231, Japan.

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http://dx.doi.org/10.1016/j.neulet.2008.06.058DOI Listing
August 2008

Syntheses of phosphatidyl-beta-D-glucoside analogues to probe antigen selectivity of monoclonal antibody 'DIM21'.

Bioorg Med Chem 2008 Aug 25;16(15):7210-7. Epub 2008 Jun 25.

RIKEN, The Institute of Physical and Chemical Research, Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.bmc.2008.06.041DOI Listing
August 2008

A role for ceramide in driving cancer cell resistance to doxorubicin.

FASEB J 2008 Jul 1;22(7):2541-51. Epub 2008 Feb 1.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, 700 University Ave., Monroe, LA 71209, USA.

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http://dx.doi.org/10.1096/fj.07-092981DOI Listing
July 2008

Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival.

Prog Lipid Res 2008 May 15;47(3):188-203. Epub 2008 Feb 15.

Hirabayashi Research Unit, RIKEN Brain Science Institute, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.plipres.2008.01.003DOI Listing
May 2008

Quantitative analysis of a novel glucosylated phospholipid by liquid chromatography-mass spectrometry.

Anal Biochem 2008 May 13;376(2):252-7. Epub 2008 Feb 13.

Hitachi High-Technologies Corp., 1-24-14 Nishi-shinbashi, Minato-ku, Tokyo 105-8717, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S000326970800076
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http://dx.doi.org/10.1016/j.ab.2008.02.007DOI Listing
May 2008

Phosphatidylglucoside: a new marker for lipid rafts.

Biochim Biophys Acta 2008 Mar 6;1780(3):405-9. Epub 2007 Sep 6.

Hirabayashi Research Unit, Brain Science Institute, The Institute of Physical and Chemical Research (RIKEN), Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.bbagen.2007.08.016DOI Listing
March 2008

Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation.

Int Immunopharmacol 2008 Jan 1;8(1):59-70. Epub 2007 Nov 1.

Department of Hard Tissue Engineering, Biochemistry, Division of Bio-Matrix, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo 113-8549, Japan.

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http://dx.doi.org/10.1016/j.intimp.2007.10.010DOI Listing
January 2008

Identification and analysis of novel glycolipids in vertebrate brains by HPLC/mass spectrometry.

Methods Enzymol 2006 ;417:155-67

Hirabayashi Laboratory Unit and CREST, Neuronal Circuit Mechanisms Research Group, Brain Science Institute RIKEN, Saitama, Japan.

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http://dx.doi.org/10.1016/S0076-6879(06)17012-3DOI Listing
October 2007

Immunohistochemical distribution of phosphatidylglucoside using anti-phosphatidylglucoside monoclonal antibody (DIM21).

Biochem Biophys Res Commun 2007 Oct 24;362(2):252-5. Epub 2007 Jul 24.

Department of Microbiology and Pathology, Field of Molecular Pathology, Faculty of Medicine, Tottori University, Nishi-chyou 86, Yonago 683-8503, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.07.065DOI Listing
October 2007

Sensitivity of phosphatidylglucoside against phospholipases.

Anal Biochem 2007 Jun 13;365(1):149-51. Epub 2007 Feb 13.

Neuronal Circuit Mechanisms Research Group, Brain Science Institute, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.ab.2007.02.008DOI Listing
June 2007

Glycolipids with nonreducing end alpha-mannosyl residues that have the potential to activate invariant Valpha19 NKT cells.

FEBS J 2007 Jun 4;274(11):2921-32. Epub 2007 May 4.

Developmental Immunology Unit, Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan.

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http://dx.doi.org/10.1111/j.1742-4658.2007.05826.xDOI Listing
June 2007

Identification and characterization of human ethanolaminephosphotransferase1.

J Lipid Res 2007 Mar 28;48(3):503-8. Epub 2006 Nov 28.

Neuronal Circuit Mechanisms Research Group, Brain Science Institute, RIKEN, Hirosawa 2-1, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1194/jlr.C600019-JLR200DOI Listing
March 2007

Drosophila beta 1,4-N-acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids.

Biochem Biophys Res Commun 2007 Mar 11;354(2):522-7. Epub 2007 Jan 11.

Laboratory of Cell Biology, Department of Bioinformatics, Faculty of Engineering, Soka University, 1-236 Hachioji, Tokyo 192-8577, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.01.015DOI Listing
March 2007

Lipid rafts: new tools and a new component.

Biol Pharm Bull 2006 Aug;29(8):1526-31

Lipid Biology Laboratory, RIKEN (Institute of Physical and Chemical Research), Japan.

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http://dx.doi.org/10.1248/bpb.29.1526DOI Listing
August 2006

Role of glycosphingolipids and therapeutic perspectives on Alzheimer's disease.

CNS Neurol Disord Drug Targets 2006 Aug;5(4):375-80

Department of Neurology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

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http://dx.doi.org/10.2174/187152706777950710DOI Listing
August 2006

Phosphatidylglucoside exists as a single molecular species with saturated fatty acyl chains in developing astroglial membranes.

Biochemistry 2006 Jul;45(29):8742-50

Hirabayashi Research Unit, Neuronal Circuit Mechanisms Research Group, and Laboratory for Neuronal Architecture, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1021/bi0606546DOI Listing
July 2006

Comprehensive analysis of monoclonal antibodies against detergent-insoluble membrane/lipid rafts of HL60 cells.

J Immunol Methods 2006 Apr 9;311(1-2):106-16. Epub 2006 Mar 9.

Laboratory for Neural Architecture, Advanced Technology Development Group, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.jim.2006.01.019DOI Listing
April 2006

Gangliosides are not essential for influenza virus infection.

Glycoconj J 2006 Feb;23(1-2):107-13

Institute of Virology, Philipps University, Robert Koch str. 17, 35037, Marburg, Germany.

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http://dx.doi.org/10.1007/s10719-006-5443-yDOI Listing
February 2006