Yoshihiro Nakajima

Yoshihiro Nakajima

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Yoshihiro Nakajima

Yoshihiro Nakajima

Publications by authors named "Yoshihiro Nakajima"

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64Publications

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Reactive oxygen species independent genotoxicity of indium tin oxide nanoparticles triggered by intracellular degradation.

Food Chem Toxicol 2018 Aug 14;118:264-271. Epub 2018 May 14.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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August 2018

Bioluminescence-based cytotoxicity assay for simultaneous evaluation of cell viability and membrane damage in human hepatoma HepG2 cells.

Luminescence 2018 May 8;33(3):616-624. Epub 2018 Feb 8.

Chromosome Engineering Research Center, Tottori University, Yonago, Tottori, Japan.

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May 2018

Yuzu (Citrus junos Tanaka) Peel Attenuates Dextran Sulfate Sodium-induced Murine Experimental Colitis.

J Oleo Sci 2018 Mar 19;67(3):335-344. Epub 2018 Feb 19.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST).

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March 2018

Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes.

Mol Ther Nucleic Acids 2018 Mar 14;10:64-74. Epub 2017 Nov 14.

Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2-17-2-1 Tsukisamu-Higashi, Toyohira-ku, Sapporo 062-8517, Japan. Electronic address:

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March 2018

Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics.

Drug Metab Pharmacokinet 2018 Feb 11;33(1):17-30. Epub 2018 Jan 11.

Chromosome Engineering Research Center (CERC), Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan; Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Sciences, Tottori University, 86 Nishi-cho, Yonago, Tottori, 683-8503, Japan. Electronic address:

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February 2018

Antioxidant properties of 5-hydroxy-4-phenyl-butenolide via activation of Nrf2/ARE signaling pathway.

Food Chem Toxicol 2017 Sep 24;107(Pt A):129-137. Epub 2017 Jun 24.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan. Electronic address:

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September 2017

Effect of calcium carbonate particle shape on phagocytosis and pro-inflammatory response in differentiated THP-1 macrophages.

Biochem Biophys Res Commun 2017 08 15;490(2):499-505. Epub 2017 Jun 15.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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August 2017

A Novel Dual-Color Luciferase Reporter Assay for Simultaneous Detection of Estrogen and Aryl Hydrocarbon Receptor Activation.

Chem Res Toxicol 2017 07 3;30(7):1436-1447. Epub 2017 Jul 3.

German Federal Institute for Risk Assessment , Department of Chemical and Product Safety, Max-Dohrn-Strasse 8-10, 10589 Berlin, Germany.

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July 2017

Continuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement.

BMC Biotechnol 2017 06 20;17(1):54. Epub 2017 Jun 20.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa, 761-0395, Japan.

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June 2017

Dissociation of and circadian rhythms in the suprachiasmatic nucleus in parallel with behavioral outputs.

Proc Natl Acad Sci U S A 2017 05 17;114(18):E3699-E3708. Epub 2017 Apr 17.

Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Japan.

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May 2017

Enhanced in-cell folding of reversibly cationized transcription factor using amphipathic peptide.

J Biosci Bioeng 2017 Apr 16;123(4):419-424. Epub 2017 Jan 16.

Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan. Electronic address:

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April 2017

Development of N- and O-linked oligosaccharide engineered Saccharomyces cerevisiae strain.

Glycobiology 2016 11 12;26(11):1248-1256. Epub 2016 Jul 12.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi, Takamatsu, Kagawa 761-0395, Japan.

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November 2016

Antioxidative and Antidiabetic Effects of Natural Polyphenols and Isoflavones.

Molecules 2016 May 30;21(6). Epub 2016 May 30.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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May 2016

Involvement of splenic iron accumulation in the development of nonalcoholic steatohepatitis in Tsumura Suzuki Obese Diabetes mice.

Sci Rep 2016 Mar 2;6:22476. Epub 2016 Mar 2.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.

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March 2016

Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage.

J Biochem 2016 Feb 15;159(2):225-37. Epub 2015 Sep 15.

Health Research Institute, National Institute of Advanced Industrial Science and Technology, 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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February 2016

Spatiotemporal profiles of arginine vasopressin transcription in cultured suprachiasmatic nucleus.

Eur J Neurosci 2015 Nov 5;42(9):2678-89. Epub 2015 Oct 5.

Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638, Japan.

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November 2015

Optimization of the IL-8 Luc assay as an in vitro test for skin sensitization.

Toxicol In Vitro 2015 Oct 15;29(7):1816-30. Epub 2015 Jul 15.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan; Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 305-8566, Japan. Electronic address:

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October 2015

Oleuropein-Rich Diet Attenuates Hyperglycemia and Impaired Glucose Tolerance in Type 2 Diabetes Model Mouse.

J Agric Food Chem 2015 Aug 28;63(30):6715-22. Epub 2015 Jul 28.

†Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan.

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August 2015

Mutagenicity and clastogenicity of extracts of Helicobacter pylori detected by the Ames test and in the micronucleus test using human lymphoblastoid cells.

Mutagenesis 2015 Jul 24;30(4):537-44. Epub 2015 Mar 24.

Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Okayama University of Science, Ridai-cho Kita-ku, Okayama 700-0005, Japan.

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July 2015

The impact of HIF1α on the Per2 circadian rhythm in renal cancer cell lines.

PLoS One 2014 21;9(10):e109693. Epub 2014 Oct 21.

Department of Physiology, Saitama Medical University, Saitama, Japan; Molecular Clock Project, Project Research Division, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.

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June 2015

In vitro evaluation of the cellular effect of indium tin oxide nanoparticles using the human lung adenocarcinoma A549 cells.

Metallomics 2015 May 17;7(5):816-27. Epub 2015 Mar 17.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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May 2015

Highly sensitive luciferase reporter assay using a potent destabilization sequence of calpain 3.

J Biotechnol 2015 Jan 18;194:115-23. Epub 2014 Dec 18.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395, Japan. Electronic address:

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January 2015

Type 2 diabetes model TSOD mouse is exposed to oxidative stress at young age.

J Clin Biochem Nutr 2014 Nov 27;55(3):216-20. Epub 2014 Aug 27.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu, Kagawa 761-0395, Japan.

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November 2014

Development of an artificial calcium-dependent transcription factor to detect sustained intracellular calcium elevation.

ACS Synth Biol 2014 Oct 9;3(10):717-22. Epub 2014 Sep 9.

Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University , Miki-cho, Kagawa 761-0793, Japan.

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October 2014

Protease-deficient Saccharomyces cerevisiae strains for the synthesis of human-compatible glycoproteins.

Biosci Biotechnol Biochem 2013 7;77(12):2461-6. Epub 2013 Dec 7.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST).

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August 2014

Real-time analysis of the circadian oscillation of the Rev-Erb β promoter.

J Atheroscler Thromb 2013 7;20(3):267-76. Epub 2012 Dec 7.

Department of Neurology, Meitan General Hospital, Beijing, China.

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September 2013

Regional circadian period difference in the suprachiasmatic nucleus of the mammalian circadian center.

Eur J Neurosci 2013 Sep 22;38(6):2832-41. Epub 2013 Jul 22.

Department of Anatomy and Neurobiology, Faculty of Medicine, Kinki University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan.

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September 2013

Monitoring circadian time in rat plasma using a secreted Cypridina luciferase reporter.

Anal Biochem 2013 Aug 25;439(2):80-7. Epub 2013 Apr 25.

Photonic Bioimaging Section, Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.

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August 2013

Surface functionalization of a polymeric lipid bilayer for coupling a model biological membrane with molecules, cells, and microstructures.

Langmuir 2013 Feb 14;29(8):2722-30. Epub 2013 Feb 14.

Research Center for Environmental Genomics, Kobe University, Rokkodaicho 1-1, Nada, Kobe 657-8501, Japan.

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February 2013

A dual-color luciferase assay system reveals circadian resetting of cultured fibroblasts by co-cultured adrenal glands.

PLoS One 2012 15;7(5):e37093. Epub 2012 May 15.

Health Research Institute, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan.

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January 2013

In vivo monitoring of peripheral circadian clocks in the mouse.

Curr Biol 2012 Jun 10;22(11):1029-34. Epub 2012 May 10.

Department of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo 162-8480, Japan.

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June 2012

Period coding of Bmal1 oscillators in the suprachiasmatic nucleus.

J Neurosci 2012 Jun;32(26):8900-18

Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan.

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June 2012

An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8.

Toxicol Sci 2011 Dec 13;124(2):359-69. Epub 2011 Sep 13.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi 980-8574, Japan.

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December 2011

Quantum yields and kinetics of the firefly bioluminescence reaction of beetle luciferases.

Photochem Photobiol 2010 Sep-Oct;86(5):1046-9

National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology(AIST), Tsukuba, Japan.

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March 2011

Coactivation of the CLOCK-BMAL1 complex by CBP mediates resetting of the circadian clock.

J Cell Sci 2010 Oct;123(Pt 20):3547-57

Department of Biological Sciences and 21st Frontier Program in Neuroscience, Seoul National University, Seoul 151-742, Korea.

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October 2010

Dual-color luciferase mouse directly demonstrates coupled expression of two clock genes.

Biochemistry 2010 Sep;49(37):8053-61

National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan.

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September 2010

Bioluminescence assays: multicolor luciferase assay, secreted luciferase assay and imaging luciferase assay.

Expert Opin Drug Discov 2010 Sep 21;5(9):835-49. Epub 2010 Jul 21.

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka, Japan.

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September 2010

Bioluminescence imaging of dual gene expression at the single-cell level.

Biotechniques 2010 Jun;48(6):460-2

Regenerative Medicine/Tissue Engineering Division, Research Center for Cooperative Projects, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

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June 2010

Enhanced beetle luciferase for high-resolution bioluminescence imaging.

PLoS One 2010 Apr 2;5(4):e10011. Epub 2010 Apr 2.

National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan.

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April 2010

A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma.

J Atheroscler Thromb 2010 Feb 21;17(1):73-83. Epub 2010 Jan 21.

Department of Diabetes and Endocrinology, Saitama Medical University, Saitama 350-0495, Japan.

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February 2010

Applications of luciferin biosynthesis: Bioluminescence assays for l-cysteine and luciferase.

Anal Biochem 2010 Jan 11;396(2):316-8. Epub 2009 Sep 11.

National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305-8568, Japan.

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January 2010

Enhanced red-emitting railroad worm luciferase for bioassays and bioimaging.

Protein Sci 2010 Jan;19(1):26-33

Cell Dynamics Research Group, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Ikeda, Osaka 563-8577, Japan.

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January 2010

The molecular mechanism regulating the autonomous circadian expression of Topoisomerase I in NIH3T3 cells.

Biochem Biophys Res Commun 2009 Feb 10;380(1):22-7. Epub 2009 Jan 10.

Department of Physiology, Saitama Medical University, 38 Morohongo, Moroyama, Iruma-gun, Saitama 350-0495, Japan.

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February 2009

Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance.

J Biol Chem 2008 Jun 5;283(26):18218-26. Epub 2008 May 5.

Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

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June 2008

Simultaneous monitoring of independent gene expression patterns in two types of cocultured fibroblasts with different color-emitting luciferases.

BMC Biotechnol 2008 Apr 17;8:40. Epub 2008 Apr 17.

Cell Dynamics Research Group, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577, Japan.

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April 2008

Luciferase-YFP fusion tag with enhanced emission for single-cell luminescence imaging.

Nat Methods 2007 Aug 8;4(8):637-9. Epub 2007 Jul 8.

Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Osaka 563-8577, Japan.

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August 2007

New reporter system for Per1 and Bmal1 expressions revealed self-sustained circadian rhythms in peripheral tissues.

Genes Cells 2006 Oct;11(10):1173-82

Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.

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October 2006

A new additional reporter enzyme, dinoflagellate luciferase, for monitoring of gene expression in mammalian cells.

Gene 2005 Jan 19;344:61-6. Epub 2004 Nov 19.

Toyo B-net Corporation, 3-5-1, Wadai, Tsukuba 432-8011, Japan.

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January 2005

Bidirectional role of orphan nuclear receptor RORalpha in clock gene transcriptions demonstrated by a novel reporter assay system.

FEBS Lett 2004 May;565(1-3):122-6

Cell Dynamics Research Group, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Midorigaoka, Ikeda, Osaka 563-8577, Japan.

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May 2004

Improved expression of novel red- and green-emitting luciferases of Phrixothrix railroad worms in mammalian cells.

Biosci Biotechnol Biochem 2004 Apr;68(4):948-51

Cell Dynamics Research Group, Research Institute for Cell Engineering, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan.

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April 2004

cDNA cloning and characterization of a secreted luciferase from the luminous Japanese ostracod, Cypridina noctiluca.

Biosci Biotechnol Biochem 2004 Mar;68(3):565-70

Cell Dynamics Research Group, The Special Division for Human Life Technology, National Institute of Advanced Industrial Science and Technology, Ikeda, Osaka, Japan.

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March 2004