Publications by authors named "Yoshihide Kanaoka"

52Publications

Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2.

Sci Immunol 2020 01 17;5(43). Epub 2020 Jan 17.

Division of Allergy and Clinical Immunology, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA, USA.

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January 2020

Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions.

Adv Immunol 2019 14;142:65-84. Epub 2019 May 14.

Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA, United States. Electronic address:

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April 2020

The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation.

Sci Immunol 2018 10;3(28)

Division of Rheumatology, Immunology and Allergy, Jeff and Penny Vinik Center for Allergic Disease Research, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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October 2018

Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity.

J Immunol 2018 02 27;200(3):915-927. Epub 2017 Dec 27.

Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115;

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February 2018

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s.

J Exp Med 2017 01 23;214(1):27-37. Epub 2016 Dec 23.

Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143

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January 2017

CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma.

J Immunol 2016 07 25;197(1):266-77. Epub 2016 May 25.

Meakins-Christie Laboratories, McGill University Health Centre and McGill University, Montreal, Quebec H4A 3J1, Canada;

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July 2016

Phosphoinositide 3-Kinase δ Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity.

J Immunol 2016 07 18;197(1):278-87. Epub 2016 May 18.

Department of Medicine, Harvard Medical School, Boston, MA 02115; Jeff and Penny Vinik Center for Allergic Disease Research, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115;

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July 2016

Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99.

Proc Natl Acad Sci U S A 2016 May 16;113(22):6242-7. Epub 2016 May 16.

Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Boston, MA 02115; Department of Medicine, Harvard Medical School, Boston, MA 02115

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May 2016

Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway.

J Immunol 2015 Oct 4;195(8):3537-45. Epub 2015 Sep 4.

Department of Medicine, Harvard Medical School, Boston, MA 02115; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115; Jeff and Penny Vinik Center for Allergic Disease Research, Boston, MA 02115; Department of Pediatrics, Harvard Medical School, Boston, MA 02115

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October 2015

Cysteinyl leukotrienes and their receptors; emerging concepts.

Allergy Asthma Immunol Res 2014 Jul 27;6(4):288-95. Epub 2014 May 27.

Jeff and Penny Vinik Center for Allergic Disease Research, Boston, MA, United States. ; Department of Medicine, Harvard Medical School; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, United States.

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July 2014

Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand.

J Biol Chem 2013 Apr 15;288(16):10967-72. Epub 2013 Mar 15.

Department of Medicine, Harvard Medical School and the Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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April 2013

A leukotriene C4 synthase inhibitor with the backbone of 5-(5-methylene-4-oxo-4,5-dihydrothiazol-2-ylamino) isophthalic acid.

J Biochem 2013 May 31;153(5):421-9. Epub 2013 Jan 31.

Structural Biophysics Laboratory, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan, USA.

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May 2013

Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice.

Anesthesiology 2011 Oct;115(4):804-11

Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.

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October 2011

[Cysteinyl reukotriene receptors].

Seikagaku 2011 Jul;83(7):609-14

Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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July 2011

The catalytic architecture of leukotriene C4 synthase with two arginine residues.

J Biol Chem 2011 May 16;286(18):16392-401. Epub 2011 Mar 16.

Structural Biophysics Laboratory, RIKEN SPring-8 Center, Harima Institute, Sayo, Hyogo, Japan.

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May 2011

Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes.

J Exp Med 2011 Mar 28;208(3):593-604. Epub 2011 Feb 28.

Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.

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March 2011

Oxidative stress suppresses cysteinyl leukotriene generation by mouse bone marrow-derived mast cells.

J Biol Chem 2011 Mar 13;286(10):8277-86. Epub 2011 Jan 13.

Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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March 2011

GPR17 regulates immune pulmonary inflammation induced by house dust mites.

J Immunol 2010 Aug 23;185(3):1846-54. Epub 2010 Jun 23.

Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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August 2010

Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor.

J Exp Med 2009 Oct 12;206(11):2543-55. Epub 2009 Oct 12.

Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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October 2009

The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications.

J Allergy Clin Immunol 2009 Sep 3;124(3):406-14; quiz 415-6. Epub 2009 Aug 3.

Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, Mass 02115, USA.

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September 2009

GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4.

Proc Natl Acad Sci U S A 2009 Jul 26;106(28):11685-90. Epub 2009 Jun 26.

Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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July 2009

P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells.

J Immunol 2009 Jan;182(2):1129-37

Department of Medicine, Harvard Medical School and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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January 2009

Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells.

J Immunol 2009 Jan;182(2):1119-28

Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA.

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January 2009

Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors.

Proc Natl Acad Sci U S A 2008 Oct 17;105(43):16695-700. Epub 2008 Oct 17.

Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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October 2008

Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis.

Nature 2007 Aug 15;448(7153):609-12. Epub 2007 Jul 15.

Structural Biophysics Laboratory, RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo, Hyogo 679-5148, Japan.

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August 2007

Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice.

Cancer Res 2007 Feb;67(3):881-9

Division of Medical Genetics, Department of Pediatrics and Department of Pathology, Los Angeles Biomedical Research Institute, Harbor-University of California-Los Angeles Medical Center, 1124 West Carson Street, Torrance, CA 90502, USA.

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February 2007

Neutrophil-derived leukotriene B4 is required for inflammatory arthritis.

J Exp Med 2006 Apr 27;203(4):837-42. Epub 2006 Mar 27.

Department of Medicine and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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April 2006

Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.

Proc Natl Acad Sci U S A 2006 Mar 17;103(13):5179-84. Epub 2006 Mar 17.

Experimental Pathology, St. Bartholomew's and the London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, United Kingdom.

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March 2006

Human leukotriene C(4) synthase at 4.5 A resolution in projection.

Structure 2004 Nov;12(11):2009-14

Department of Structural Biology, Max-Planck-Institute of Biophysics, Marie-Curie-Strasse 15, 60439 Frankfurt am Main, Germany.

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November 2004

Cysteinyl leukotrienes and their receptors: cellular distribution and function in immune and inflammatory responses.

J Immunol 2004 Aug;173(3):1503-10

Department of Medicine, Harvard University Medical School and Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston MA 02115, USA.

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August 2004

Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis.

Proc Natl Acad Sci U S A 2004 Mar 17;101(9):3047-52. Epub 2004 Feb 17.

Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

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March 2004

Hematopoietic prostaglandin D synthase.

Prostaglandins Leukot Essent Fatty Acids 2003 Aug-Sep;69(2-3):163-7

Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Smith Building, Room 626C One Jimmy Fund Way, Boston, MA 02115, USA.

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April 2004

Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses.

J Biol Chem 2002 Jun 3;277(23):20820-4. Epub 2002 Apr 3.

Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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June 2002