Yoshiaki Kitamura

Yoshiaki Kitamura

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Yoshiaki Kitamura

Publications by authors named "Yoshiaki Kitamura"

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A new immunohistochemical method to evaluate the development of vestibular compensation after unilateral labyrinthectomy in rats.

Acta Otolaryngol 2019 Jun 16;139(6):505-510. Epub 2019 Apr 16.

a Department of Otolaryngology , Institute of Biomedical Sciences, Tokushima University Graduate School , Tokushima , Japan.

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http://dx.doi.org/10.1080/00016489.2019.1599140DOI Listing
June 2019

Dom34 mediates targeting of exogenous RNA in the antiviral OAS/RNase L pathway.

Nucleic Acids Res 2019 Jan;47(1):432-449

Department of Biological Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467-8603, Japan.

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https://academic.oup.com/nar/advance-article/doi/10.1093/nar
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http://dx.doi.org/10.1093/nar/gky1087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326797PMC
January 2019

Effect of Royal Jelly and Brazilian Green Propolis on the Signaling for Histamine H Receptor and Interleukin-9 Gene Expressions Responsible for the Pathogenesis of the Allergic Rhinitis.

Biol Pharm Bull 2018 ;41(9):1440-1447

Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School.

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http://dx.doi.org/10.1248/bpb.b18-00325DOI Listing
November 2018

Cyclic arylopeptoid oligomers: synthesis and conformational propensities of peptide-mimetic aromatic macrocycles.

Org Biomol Chem 2018 11;16(44):8505-8512

Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1039/c8ob01962bDOI Listing
November 2018

Synthesis of cationic glucosamino nucleic acids for stabilizing oligonucleotides.

Bioorg Med Chem Lett 2018 10 25;28(19):3174-3176. Epub 2018 Aug 25.

Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, Aichi 470-0392, Japan. Electronic address:

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https://www.sciencedirect.com/journal/bioorganic-and-medicin
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https://linkinghub.elsevier.com/retrieve/pii/S0960894X183070
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http://dx.doi.org/10.1016/j.bmcl.2018.08.024DOI Listing
October 2018

Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats.

J Pharmacol Sci 2018 Sep 10;138(1):54-62. Epub 2018 Sep 10.

Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.

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http://dx.doi.org/10.1016/j.jphs.2018.08.011DOI Listing
September 2018

GH30 Glucuronoxylan-Specific Xylanase from Streptomyces turgidiscabies C56.

Appl Environ Microbiol 2018 02 31;84(4). Epub 2018 Jan 31.

Department of Subtropical Biochemistry and Biotechnology, Faculty of Agriculture, University of the Ryukyus, Nishihara, Okinawa, Japan

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http://dx.doi.org/10.1128/AEM.01850-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795079PMC
February 2018

Introduction of 2-O-benzyl abasic nucleosides to the 3'-overhang regions of siRNAs greatly improves nuclease resistance.

Bioorg Med Chem Lett 2017 12 28;27(24):5454-5456. Epub 2017 Oct 28.

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, Aichi 470-0392, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.10.070DOI Listing
December 2017

Histamine H Receptor Gene Expression and Drug Action of Antihistamines.

Handb Exp Pharmacol 2017 ;241:161-169

Department of Otolaryngology and Communicative Neuroscience, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 770-8503, Japan.

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http://dx.doi.org/10.1007/164_2016_14DOI Listing
October 2017

Nucleobase azide-ethynylribose click chemistry contributes to stabilizing oligonucleotide duplexes and stem-loop structures.

Bioorg Med Chem Lett 2017 06 8;27(12):2655-2658. Epub 2017 Apr 8.

Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, Aichi 470-0392, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.04.023DOI Listing
June 2017

Synthesis of Nucleic Acid Mimics and Their Application in Nucleic Acid-based Medicine.

Yakugaku Zasshi 2016 ;136(11):1491-1499

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University.

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http://dx.doi.org/10.1248/yakushi.16-00180DOI Listing
April 2017

Irradiation with narrowband-ultraviolet B suppresses phorbol ester-induced up-regulation of H1 receptor mRNA in HeLa cells.

Acta Otolaryngol 2016 29;136(4):409-13. Epub 2016 Jan 29.

a Department of Otolaryngology , Institute of Medical Biosciences, Tokushima University Graduate School , Tokushima , Japan ;

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http://dx.doi.org/10.3109/00016489.2015.1129555DOI Listing
January 2017

Practical and Reliable Synthesis of 1,2-Dideoxy-d-ribofuranose and its Application in RNAi Studies.

Nucleosides Nucleotides Nucleic Acids 2016 29;35(2):64-75. Epub 2016 Jan 29.

a United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University , 1-1 Yanagido, Gifu , Japan.

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http://dx.doi.org/10.1080/15257770.2015.1114128DOI Listing
December 2016

Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites.

J Pharmacol Toxicol Methods 2015 Nov-Dec;76:83-95. Epub 2015 Aug 24.

DMPK Research Laboratory, Watarase Research Center, Kyorin Pharmaceutical Co., Ltd., 1848, Nogi, Nogi-machi, Shimotsuga-gun, Tochigi 329-0114, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.vascn.2015.08.157DOI Listing
September 2016

Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.

Bioorg Med Chem 2016 08 16;24(16):3870-4. Epub 2016 Jun 16.

Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Applied Chemistry, Faculty of Engineering, Aichi Institute of Technology, 1247 Yachigusa, Yakusa-cho, Toyota, Aichi 470-0392, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.06.033DOI Listing
August 2016

Antihistamines suppress upregulation of histidine decarboxylase gene expression with potencies different from their binding affinities for histamine H1 receptor in toluene 2,4-diisocyanate-sensitized rats.

J Pharmacol Sci 2016 Apr 11;130(4):212-8. Epub 2016 Feb 11.

Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto, Tokushima 770-8503, Japan.

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http://dx.doi.org/10.1016/j.jphs.2016.02.002DOI Listing
April 2016

Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats.

J Pharmacol Sci 2016 Mar 6;130(3):151-8. Epub 2016 Jan 6.

Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School, Kuramoto, Tokushima 770-8503, Japan.

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http://dx.doi.org/10.1016/j.jphs.2015.12.008DOI Listing
March 2016

A novel benzofuran, 4-methoxybenzofuran-5-carboxamide, from Tephrosia purpurea suppressed histamine H1 receptor gene expression through a protein kinase C-δ-dependent signaling pathway.

Int Immunopharmacol 2016 Jan 24;30:18-26. Epub 2015 Nov 24.

Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School, Fujii Memorial Institute of Medical Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.

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http://dx.doi.org/10.1016/j.intimp.2015.11.021DOI Listing
January 2016

Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit.

J Pharmacol Sci 2015 Nov 30;129(3):183-7. Epub 2015 Oct 30.

Department of Otolaryngology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.

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http://dx.doi.org/10.1016/j.jphs.2015.10.007DOI Listing
November 2015

A proposal of a pharmacokinetic/pharmacodynamic (PK/PD) index map for selecting an optimal PK/PD index from conventional indices (AUC/MIC, Cmax/MIC, and TAM) for antibiotics.

Drug Metab Pharmacokinet 2014 8;29(6):455-62. Epub 2014 Jul 8.

Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd.

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http://dx.doi.org/10.2133/dmpk.DMPK-14-RG-013DOI Listing
October 2015

Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin-4 genes.

Pharmacol Res Perspect 2015 Oct 10;3(5):e00166. Epub 2015 Aug 10.

Department of Molecular Studies for Incurable Diseases, Institute of Biomedical Sciences, Tokushima University Graduate School 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.

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http://dx.doi.org/10.1002/prp2.166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618638PMC
October 2015

Quantitative Analysis of the ABCG2 c.421C>A Polymorphism Effect on In Vivo Transport Activity of Breast Cancer Resistance Protein (BCRP) Using an Intestinal Absorption Model.

J Pharm Sci 2015 Sep 30;104(9):3039-48. Epub 2015 Jan 30.

Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Research Cluster for Innovation, Yokohama, Japan.

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http://dx.doi.org/10.1002/jps.24366DOI Listing
September 2015

Bioenergetics and gene silencing approaches for unraveling nucleotide recognition by the human EIF2C2/Ago2 PAZ domain.

PLoS One 2014 2;9(5):e94538. Epub 2014 May 2.

United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan; Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0094538PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4008379PMC
December 2014

Synthesis of acetylene-substituted probes with benzene-phosphate backbones for RNA labeling.

Curr Protoc Nucleic Acid Chem 2014 Jun 24;57:4.59.1-15. Epub 2014 Jun 24.

Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan.

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http://dx.doi.org/10.1002/0471142700.nc0459s57DOI Listing
June 2014

Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides.

Bioorg Med Chem Lett 2014 Mar 8;24(6):1519-22. Epub 2014 Feb 8.

United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2014.01.082DOI Listing
March 2014

Combination of leukotoriene receptor antagonist with antihistamine has an additive suppressive effect on the up-regulation of H1-receptor mRNA in the nasal mucosa of toluene 2,4-diisocyanate-sensitized rat.

J Pharmacol Sci 2013 25;122(1):55-8. Epub 2013 Apr 25.

Department of Otolaryngology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.

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December 2013

Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.

J Leukoc Biol 2013 Nov 31;94(5):1013-24. Epub 2013 Jul 31.

1.Laboratory of Molecular Immunogenetics, NIAMS, NIH, Building 10, Room 13C103, Bethesda, MD 20892. J.R., E-mail:

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http://dx.doi.org/10.1189/jlb.0313163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800067PMC
November 2013

Relationship between the urinary excretion mechanisms of drugs and their physicochemical properties.

J Pharm Sci 2013 Sep 27;102(9):3294-301. Epub 2013 May 27.

Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1002/jps.23599DOI Listing
September 2013

Synthesis of carbocyclic pyrimidine nucleosides and their inhibitory activities against Plasmodium falciparum thymidylate kinase.

Parasitol Int 2013 Aug 10;62(4):368-71. Epub 2013 Apr 10.

United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.parint.2013.03.009DOI Listing
August 2013

Chemically modified siRNAs and miRNAs bearing urea/thiourea-bridged aromatic compounds at their 3'-end for RNAi therapy.

Bioorg Med Chem 2013 Aug 4;21(15):4494-501. Epub 2013 Jun 4.

Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.bmc.2013.05.046DOI Listing
August 2013

Synthesis of oligonucleotides with glucosamine at the 3'-position and evaluation of their biological activity.

Bioorg Med Chem Lett 2013 Jul 20;23(14):4157-61. Epub 2013 May 20.

United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2013.05.036DOI Listing
July 2013

PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H(1) receptor.

Sci Rep 2012 3;2:916. Epub 2012 Dec 3.

Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8505, Japan.

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http://dx.doi.org/10.1038/srep00916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512088PMC
May 2013

Molecular characterization and mutational analysis of recombinant diadenosine 5',5″-P¹,P⁴-tetraphosphate hydrolase from Plasmodium falciparum.

Biol Pharm Bull 2012 ;35(7):1191-6

United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Japan.

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December 2012

Carbocyclic thymidine derivatives efficiently inhibit Plasmodium falciparum thymidylate kinase (PfTMK).

Parasitol Int 2012 Sep 9;61(3):501-3. Epub 2012 Mar 9.

Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.parint.2012.03.001DOI Listing
September 2012

Effects of dietary zinc deprivation on zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in serum of mice.

Auris Nasus Larynx 2012 Jun 20;39(3):294-7. Epub 2011 Aug 20.

Project for the National Health and Nutrition Survey, Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S03858146110018
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http://dx.doi.org/10.1016/j.anl.2011.05.007DOI Listing
June 2012

Synthesis and biological properties of chemically modified siRNAs bearing 1-deoxy-D-ribofuranose in their 3'-overhang region.

Bioorg Med Chem Lett 2012 Apr 11;22(7):2518-21. Epub 2012 Feb 11.

Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2012.01.132DOI Listing
April 2012

Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms.

Bioorg Med Chem 2012 Jan 1;20(1):16-24. Epub 2011 Dec 1.

Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.bmc.2011.11.045DOI Listing
January 2012

Dietary zinc intake and its effects on zinc nutrition in healthy Japanese living in the central area of Japan.

J Med Invest 2011 Aug;58(3-4):203-9

Project for National Health and Nutrition Survey, Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan.

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August 2011

Prorocentrol, a polyoxy linear carbon chain compound isolated from the toxic dinoflagellate Prorocentrum hoffmannianum.

J Org Chem 2011 May 22;76(9):3131-8. Epub 2011 Mar 22.

Department of Chemistry, School of Science, University of Tokyo, 7-3-1 Hongo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1021/jo102585kDOI Listing
May 2011

Synthesis of oligonucleotides possessing versatile probes for PET labelling and their rapid ligand-free click reaction.

Chem Commun (Camb) 2011 Mar 12;47(9):2691-3. Epub 2011 Jan 12.

United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan.

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http://dx.doi.org/10.1039/c0cc04979dDOI Listing
March 2011

[Histamine H₁ receptor gene as an allergic diseases-sensitive gene and its impact on therapeutics for allergic diseases].

Yakugaku Zasshi 2011 Feb;131(2):171-8

Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School.

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February 2011

Synthesis and properties of oligodeoxynucleotides containing biaryl units.

Nucleic Acids Symp Ser (Oxf) 2009 (53):27-8

Department of Biomolecular Science, Faculty of Engineering, Gifu University, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1093/nass/nrp014DOI Listing
May 2010

The exceptional properties of Plasmodium deoxyguanylate pathways as a potential area for metabolic and drug discovery studies.

Nucleic Acids Symp Ser (Oxf) 2009 (53):39-40

Department of Biomolecular Science, Faculty of Engineering, Center for Advanced Drug Research and Center for Emerging Infectious Diseases and United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1093/nass/nrp020DOI Listing
May 2010

Introduction of 8-methyladenosine into 2', 5'-oligoadenylate (2-5A) 2'-terminus induces dramatic shift in binding site of RNase L.

Nucleic Acids Symp Ser (Oxf) 2009 (53):123-4

Department of Biomolecular Science, Faculty of Engineering, United Graduate School of Drug Discovery and Medical information Science, Gifu University, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1093/nass/nrp062DOI Listing
May 2010

Thymidylate kinase: the lost chemotherapeutic target.

Nucleic Acids Symp Ser (Oxf) 2009 (53):283-4

Department of Biomolecular Science, Faculty of Engineering, Center for Advanced Drug Research and Center for Emerging Infectious Diseases and United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1093/nass/nrp142DOI Listing
May 2010

Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice.

J Clin Invest 2010 May 19;120(5):1429-40. Epub 2010 Apr 19.

Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1172/JCI40659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860904PMC
May 2010

Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment.

Auris Nasus Larynx 2010 Apr 28;37(2):190-4. Epub 2009 Aug 28.

Department of Otolaryngology and Communicative Neuroscience, Institute of Health Bioscience University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, Japan.

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http://dx.doi.org/10.1016/j.anl.2009.07.003DOI Listing
April 2010

Basolateral efflux mediated by multidrug resistance-associated protein 3 (Mrp3/Abcc3) facilitates intestinal absorption of folates in mouse.

Pharm Res 2010 Apr 11;27(4):665-72. Epub 2010 Feb 11.

Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

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http://dx.doi.org/10.1007/s11095-009-0047-4DOI Listing
April 2010

Structure of RecJ exonuclease defines its specificity for single-stranded DNA.

J Biol Chem 2010 Mar 2;285(13):9762-9. Epub 2010 Feb 2.

Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan.

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http://dx.doi.org/10.1074/jbc.M109.096487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843225PMC
March 2010

Functional characterization of multidrug resistance-associated protein 3 (mrp3/abcc3) in the basolateral efflux of glucuronide conjugates in the mouse small intestine.

J Pharmacol Exp Ther 2010 Feb 4;332(2):659-66. Epub 2009 Nov 4.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1124/jpet.109.156943DOI Listing
February 2010

5'-O-dephosphorylated 2',5'-oligoadenylate (2-5A) with 8-methyladenosine at the 2'-terminus activates human RNase L.

Bioorg Med Chem Lett 2010 Feb 4;20(3):1186-8. Epub 2009 Dec 4.

United Graduate School of Drug Discovery and Medical Information Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2009.12.005DOI Listing
February 2010

Expression, purification and X-ray analysis of 1,3-propanediol dehydrogenase (Aq_1145) from Aquifex aeolicus VF5.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2010 Feb 28;66(Pt 2):184-6. Epub 2010 Jan 28.

National Synchrotron Radiation Research Center, 101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu 30076, Taiwan.

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http://dx.doi.org/10.1107/S1744309109052403DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815688PMC
February 2010

Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions.

Acta Crystallogr D Biol Crystallogr 2009 Oct 16;65(Pt 10):1098-106. Epub 2009 Sep 16.

Riken SPring-8 Center, Harima Institute, Sayo, Hyogo 679-5148, Japan.

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http://dx.doi.org/10.1107/S0907444909029710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756165PMC
October 2009

Glycerol-induced folding of unstructured disulfide-deficient lysozyme into a native-like conformation.

Biopolymers 2009 Aug;91(8):665-75

School of Science and Technology, Kwansei Gakuin University, Sanda, 669-1337, Japan.

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http://dx.doi.org/10.1002/bip.21198DOI Listing
August 2009

Prediction of human bioavailability from human oral administration data and animal pharmacokinetic data without data from intravenous administration of drugs in humans.

Pharm Res 2009 Aug 7;26(8):1881-9. Epub 2009 May 7.

Minase Research Institute, ONO Pharmaceutical Co., Ltd., 3-1-1, Sakurai, Shimamoto-cho, Mishima-gun, Osaka, 618-8585, Japan.

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http://dx.doi.org/10.1007/s11095-009-9902-6DOI Listing
August 2009

Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at its stem moiety.

Org Biomol Chem 2009 Jul 12;7(13):2761-9. Epub 2009 May 12.

Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan.

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http://dx.doi.org/10.1039/b901631gDOI Listing
July 2009

Sho-seiryu-to suppresses histamine signaling at the transcriptional level in TDI-sensitized nasal allergy model rats.

Allergol Int 2009 Mar 1;58(1):81-8. Epub 2008 Dec 1.

Department of Molecular Pharmacology, Institute of Health-Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.

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http://dx.doi.org/10.2332/allergolint.O-07-526DOI Listing
March 2009

Dry anaerobic ammonia-methane production from chicken manure.

Appl Microbiol Biotechnol 2009 Mar 31;82(4):757-64. Epub 2009 Jan 31.

Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Kagamiyama 1-3-1, Higashi-Hiroshima 739-8530, Japan.

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http://dx.doi.org/10.1007/s00253-009-1881-3DOI Listing
March 2009

Effect of incorporation of alkyl linkers into siRNAs on RNA interference.

Bioorg Med Chem Lett 2009 Feb 6;19(3):875-7. Epub 2008 Dec 6.

Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2008.11.107DOI Listing
February 2009

Effects of hypergravity on histamine H1 receptor mRNA expression in hypothalamus and brainstem of rats: implications for development of motion sickness.

Acta Otolaryngol 2009 Jan;129(1):45-51

Department of Otolaryngology, Institute of Health Biosciences, University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima, Japan.

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http://dx.doi.org/10.1080/00016480802008173DOI Listing
January 2009

Increasing systemic exposure of methotrexate by active efflux mediated by multidrug resistance-associated protein 3 (mrp3/abcc3).

J Pharmacol Exp Ther 2008 Nov 21;327(2):465-73. Epub 2008 Aug 21.

Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1124/jpet.108.140475DOI Listing
November 2008

Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression.

J Biol Chem 2008 Nov 6;283(48):33417-27. Epub 2008 Oct 6.

RIKEN SPring-8 Center, Harima Institute, 1-1-1 Kouto, Sayo-gun, Hyogo, 679-5148, Japan.

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http://dx.doi.org/10.1074/jbc.M806755200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662267PMC
November 2008

Synthesis of nuclease-resistant siRNAs possessing benzene-phosphate backbones in their 3'-overhang regions.

Bioorg Med Chem Lett 2008 Oct 28;18(19):5194-6. Epub 2008 Aug 28.

Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2008.08.086DOI Listing
October 2008

Modest effect of impaired P-glycoprotein on the plasma concentrations of fexofenadine, quinidine, and loperamide following oral administration in collies.

Drug Metab Dispos 2008 May 25;36(5):807-10. Epub 2008 Feb 25.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1124/dmd.107.017624DOI Listing
May 2008

Ligand-free Pd/C-catalyzed Suzuki-Miyaura coupling reaction for the synthesis of heterobiaryl derivatives.

Chem Commun (Camb) 2007 Dec 2(47):5069-71. Epub 2007 Oct 2.

Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu, 502-8585, Japan.

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http://xlink.rsc.org/?DOI=b712207a
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http://dx.doi.org/10.1039/b712207aDOI Listing
December 2007

Preliminary X-ray crystallographic study of glucose dehydrogenase from Thermus thermophilus HB8.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 May 28;63(Pt 5):446-8. Epub 2007 Apr 28.

Bioinformatics Centre (Centre of Excellence in Structural Biology and Biocomputing), Indian Institute of Science, Bangalore 560 012, India.

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http://dx.doi.org/10.1107/S1744309107014819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2334996PMC
May 2007

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic study of molybdopterin synthase from Thermus thermophilus HB8.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Apr 30;63(Pt 4):324-6. Epub 2007 Mar 30.

Bioinformatics Centre (Centre of Excellence in Structural Biology and Biocomputing), Indian Institute of Science, Bangalore 560 012, India.

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http://dx.doi.org/10.1107/S1744309107011426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2330224PMC
April 2007

Stimulation of histamine H1 receptor up-regulates histamine H1 receptor itself through activation of receptor gene transcription.

J Pharmacol Sci 2007 Apr 31;103(4):374-82. Epub 2007 Mar 31.

Department of Molecular Pharmacology, Graduate School of Health Biosciences, The University of Tokushima, Japan.

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April 2007

Zinc nutrition in healthy subjects and patients with taste impairment from the view point of zinc ingestion, serum zinc concentration and angiotensin converting enzyme activity.

Auris Nasus Larynx 2006 Sep 10;33(3):283-8. Epub 2006 Mar 10.

Department of International Public Health Nutrition, Institute of Health Bioscience University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.

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http://dx.doi.org/10.1016/j.anl.2006.01.006DOI Listing
September 2006

Dexamethasone suppresses histamine synthesis by repressing both transcription and activity of HDC in allergic rats.

Allergol Int 2006 Sep;55(3):279-86

Department of Otolaryngology, Graduate School of Health-Biosciences, The University of Tokushima, Tokushima, Japan.

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http://dx.doi.org/10.2332/allergolint.55.279DOI Listing
September 2006

Identification of catalytic amino acids of cyclodextran glucanotransferase from Bacillus circulans T-3040.

Biosci Biotechnol Biochem 2006 Aug;70(8):1947-53

National Food Research Institute, Tsukuba, Japan.

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http://dx.doi.org/10.1271/bbb.60105DOI Listing
August 2006

Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.

Clin Pharmacol Ther 2006 May 11;79(5):427-39. Epub 2006 Apr 11.

Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.clpt.2006.01.011DOI Listing
May 2006

Effect of glucocorticoid on upregulation of histamine H1 receptor mRNA in nasal mucosa of rats sensitized by exposure to toluene diisocyanate.

Acta Otolaryngol 2004 Nov;124(9):1053-8

Department of Otolaryngology, University of Tokushima School of Medicine, Tokushima, Japan.

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http://dx.doi.org/10.1080/00016480410022525DOI Listing
November 2004

The expression of vascular endothelial growth factor-A and -C, and receptors 1 and 3: correlation with lymph node metastasis and prognosis in tongue squamous cell carcinoma.

Int J Mol Med 2004 Sep;14(3):389-95

Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, Kanazawa-ku, Yokohama 236-0004, Japan.

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September 2004

The changes in mechanical properties of regenerated and residual tissues in the patellar tendon after removal of its central portion.

Clin Biomech (Bristol, Avon) 2003 Oct;18(8):765-72

Department of Sports Medicine and Joint Reconstruction Surgery, Hokkaido University School of Medicine, Kita-15 Nishi-7, Sapporo, 060-8638, Japan.

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October 2003