Publications by authors named "Yosef Shiloh"

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The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.
Mol Cell 2018 Mar;69(5):866-878.e7
The David and Inez Myers Laboratory for Cancer Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address:

Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair.
Nucleic Acids Res 2018 Jan;46(2):730-747
Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

The COP9 signalosome is vital for timely repair of DNA double-strand breaks.
Nucleic Acids Res 2015 May 8;43(9):4517-30. Epub 2015 Apr 8.
The David and Inez Myers Laboratory for Cancer Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, George S. Wise Faculty of Life sciences, Tel Aviv University, Tel Aviv, 69978 Israel

Parallel profiling of the transcriptome, cistrome, and epigenome in the cellular response to ionizing radiation.
Sci Signal 2014 May 13;7(325):rs3. Epub 2014 May 13.
The David and Inez Myers Laboratory for Cancer Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks.
Cell Cycle 2011 Dec 15;10(24):4300-10. Epub 2011 Dec 15.
The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Transcriptional modulation induced by ionizing radiation: p53 remains a central player.
Mol Oncol 2011 Aug 7;5(4):336-48. Epub 2011 Jul 7.
The David and Inez Myers Laboratory for Genetic Research, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Room 1022, Tel Aviv 69978, Israel.

ATM-mediated phosphorylation of polynucleotide kinase/phosphatase is required for effective DNA double-strand break repair.
EMBO Rep 2011 Jul 1;12(7):713-9. Epub 2011 Jul 1.
The David and Inez Myers Laboratory for Cancer Genetics, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.


Accelerated carcinogenesis following liver regeneration is associated with chronic inflammation-induced double-strand DNA breaks.
Proc Natl Acad Sci U S A 2010 Feb 25;107(5):2207-12. Epub 2010 Jan 25.
The Goldyne Savad Institute of Gene Therapy, Magnetic Resonance Imaging/Magnetic Resonance Spectroscopy Laboratory, Hadassah Hebrew University Medical Center, Jerusalem, Israel.



SPIKE--a database, visualization and analysis tool of cellular signaling pathways.
BMC Bioinformatics 2008 Feb 20;9:110. Epub 2008 Feb 20.
The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
Science 2007 May;316(5828):1160-6
Department of Genetics and Center for Genetics and Genomics, Brigham and Women's Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
J Biol Chem 2007 Mar 21;282(9):6582-7. Epub 2006 Dec 21.
Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway.
Nat Cell Biol 2006 Aug 23;8(8):870-6. Epub 2006 Jul 23.
The David and Inez Myers Laboratory for Genetic Research, Department of Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.



Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.
Proc Natl Acad Sci U S A 2005 Apr 23;102(14):5056-61. Epub 2005 Mar 23.
The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

ATM: ready, set, go.
Cell Cycle 2003 Mar-Apr;2(2):116-7
The Dovid and Inez Myers Laboratory lor Genetic Research, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

Dissection of a DNA-damage-induced transcriptional network using a combination of microarrays, RNA interference and computational promoter analysis.
Genome Biol 2005 13;6(5):R43. Epub 2005 Apr 13.
The David and Inez Myers Laboratory for Genetic Research, Department of Human Genetics, Sackler School of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel.

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