Publications by authors named "Yosef Landesman"

72Publications

Selinexor Sensitizes TRAIL-R2-Positive TNBC Cells to the Activity of TRAIL-R2xCD3 Bispecific Antibody.

Cells 2020 Oct 2;9(10). Epub 2020 Oct 2.

Biomarkers Unit, Department of Applied Research and Technical Development, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.

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http://dx.doi.org/10.3390/cells9102231DOI Listing
October 2020

Selinexor, bortezomib, and dexamethasone (SVD) in heavily treated relapsed refractory multiple myeloma.

Ann Hematol 2020 Oct 2. Epub 2020 Oct 2.

Department of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, 10 East 102nd Street, 6th Floor, New York, NY, 10029, USA.

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http://dx.doi.org/10.1007/s00277-020-04293-yDOI Listing
October 2020

Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas.

Cell Mol Life Sci 2020 Aug 26. Epub 2020 Aug 26.

Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1007/s00018-020-03620-wDOI Listing
August 2020

The Nuclear Export Inhibitor Selinexor Inhibits Hypoxia Signaling Pathways And 3D Spheroid Growth Of Cancer Cells.

Onco Targets Ther 2019 11;12:8387-8399. Epub 2019 Oct 11.

Center for Structural and Cell Biology in Medicine, Institute of Physiology, Working Group Hypoxia, University of Lübeck, Lübeck D-23562, Germany.

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https://www.dovepress.com/the-nuclear-export-inhibitor-selin
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http://dx.doi.org/10.2147/OTT.S213208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793465PMC
October 2019

The SINE Compound KPT-350 Blocks Dystrophic Pathologies in DMD Zebrafish and Mice.

Mol Ther 2020 01 3;28(1):189-201. Epub 2019 Sep 3.

Department of Pediatrics, Division of Neurology, University of Alabama at Birmingham and Children's of Alabama, Birmingham, AL 35294, USA; UAB Center for Exercise Medicine (UCEM), Birmingham, AL 35294, USA; Department of Genetics at the University of Alabama at Birmingham, Birmingham, AL 35294, USA; Civitan International Research Center at the University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2019.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952030PMC
January 2020

Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma.

N Engl J Med 2019 08;381(8):727-738

From the Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai (A.C., S.P., S.J.), and New York University Langone Medical Center (D.K.) - both in New York; the Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia (D.T.V.); the School of Medicine, National and Kapodistrian University of Athens, Athens (M.G., M. Dimopoulos); the Winship Cancer Institute, Emory University, Atlanta (A.K.N., S.L.); Massachusetts General Hospital Cancer Center (A.J.Y.), Tufts Medical Center (R.L.C.), and the Dana-Farber Cancer Institute (P.G.R.), Boston, and Karyopharm Therapeutics, Newton (M.G.K., S.S., L.L., S. Tang, C.P., J.-R.S.-M., M.C., H.C., Y.L., J.S.) - all in Massachusetts; Johns Hopkins University, Baltimore (C.A.H.); the University of Nantes, Nantes (P.M.), Hôpital Necker (L.F.), Hôpital Saint-Antoine (M.M.), and La Pitié-Salpêtrière Hospital (S.C.), Paris, University Hospital, Lille (T.F.), Centre Hospitalier Lyon Sud, Pierre-Benite (L.K.), and Centre Hospitalo-Universitaire Vandoeuvre-lès-Nancy, Nancy (A.P.) - all in France; the Mayo Clinic, Rochester, MN (D.D.); the University of Michigan, Ann Arbor (C.C.); the Mayo Clinic of Arizona, Phoenix (A.K.S.); Hackensack University Medical Center, Hackensack, NJ (J.R.); Washington University School of Medicine, St. Louis (R.V.); Lineberger Comprehensive Cancer Center at University of North Carolina-Chapel Hill, Chapel Hill (S. Tuchman); the University of Heidelberg, Heidelberg (M.S.R.), University Medical Center Hamburg-Eppendorf, Hamburg (K.C.W.), the University of Tübingen, Tübingen (K.C.W.), University Hospital Würzburg, Würzburg (M.S.), the University of Freiburg, Freiburg (M.E.), and Gemeinschaftspraxis Hämatologie-Onkologie, Dresden (T.I.) - all in Germany; the University of Leuven, Leuven (M. Delforge), Institut Jules Bordet, Université Libre de Bruxelles, Brussels (N.M.), University Hospital Ghent, Ghent (P.V.), and Centre Hospitalier Universitaire Université Catholique de Louvain Namur, Yvoir (C.D.) - all in Belgium; Vanderbilt University Medical Center, Nashville (R.F.C.); Sylvester Cancer Center, University of Miami, Miami (J.E.H.); the University of Alabama at Birmingham, Birmingham (L.J.C.); Yale School of Medicine, New Haven, CT (T.L.P.); Baylor University Medical Center, Dallas (M.L.); the David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles (G.S.); and University Hospital Krems, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria (K.P.).

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http://www.nejm.org/doi/10.1056/NEJMoa1903455
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http://dx.doi.org/10.1056/NEJMoa1903455DOI Listing
August 2019

Targeting the XPO1-dependent nuclear export of E2F7 reverses anthracycline resistance in head and neck squamous cell carcinomas.

Sci Transl Med 2018 06;10(447)

Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Translational Research Institute, Woolloongabba, Queensland 4102, Australia.

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http://dx.doi.org/10.1126/scitranslmed.aar7223DOI Listing
June 2018

FoxO-1 contributes to the efficacy of the combination of the XPO1 inhibitor selinexor and cisplatin in ovarian carcinoma preclinical models.

Biochem Pharmacol 2018 01 16;147:93-103. Epub 2017 Nov 16.

Molecular Pharmacology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, via Amadeo 42, 20133 Milan, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2017.11.009DOI Listing
January 2018

Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma.

Transl Oncol 2017 Aug 29;10(4):632-640. Epub 2017 Jun 29.

Department of Radiation Oncology, Cancer Biology Division, Washington University in Saint Louis School of Medicine, Saint Louis, MO 63108, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tranon.2017.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5496204PMC
August 2017

A novel orally bioavailable compound KPT-9274 inhibits PAK4, and blocks triple negative breast cancer tumor growth.

Sci Rep 2017 02 15;7:42555. Epub 2017 Feb 15.

Susan Lehman Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Road, Piscataway, NJ, 08854, USA.

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http://dx.doi.org/10.1038/srep42555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5309789PMC
February 2017

The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia.

Clin Cancer Res 2017 May 25;23(10):2528-2541. Epub 2016 Oct 25.

KU Leuven Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1580DOI Listing
May 2017

Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export.

Oncotarget 2016 Oct;7(42):68842-68850

Katholieke Universiteit Leuven, Department of Immunology and Microbiology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium.

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http://dx.doi.org/10.18632/oncotarget.11995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356594PMC
October 2016

ERα-XPO1 Cross Talk Controls Tamoxifen Sensitivity in Tumors by Altering ERK5 Cellular Localization.

Mol Endocrinol 2016 Oct 17;30(10):1029-1045. Epub 2016 Aug 17.

Department of Food Science and Human Nutrition (K.W., Y.C.Z., E.K., K.H., Z.M.-E.), Division of Nutritional Sciences (K.L.A.C., Z.M.-E.), University of Illinois at Urbana-Champaign, Departments of Surgery (P.S.R.) and Bioengineering (P.S.R.), Interdisciplinary Health Sciences Institute (P.S.R.), and Division of Surgical Oncology (P.S.R.), Carle Cancer Center, and Departments of Crop Sciences (A.E.L.) and Pathobiology (R.L.S.), College of Veterinary Medicine, Urbana, Illinois 61801; (J.H.), Arlington, Massachusetts; Onconostic Technologies Inc (S.L., T.R., P.S.R.), Urbana, Illinois 61820; Karyopharm Therapeutics (Y.L.), Newton, Massachusetts 02459; and Cancer Community Illinois (Z.M.-E.), Urbana, Illinois 61801.

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http://dx.doi.org/10.1210/me.2016-1101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045498PMC
October 2016

First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors.

J Clin Oncol 2016 12 31;34(34):4142-4150. Epub 2016 Oct 31.

Albiruni R. Abdul Razak and Lee-Anne Stayner, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Morten Mau-Soerensen and Ulrik Lassen, Rigshospitalet, Copenhagen, Denmark; Nashat Y. Gabrail, Gabrail Cancer Institute, Canton, OH; John F. Gerecitano, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, New York, NY; Anthony F. Shields, Karmanos Cancer Institute, Wayne State University, Detroit, MI; Thaddeus J. Unger, Jean R. Saint-Martin, Robert Carlson, Yosef Landesman, Dilara McCauley, Tami Rashal, Mansoor R. Mirza, Michael Kauffman, and Sharon Shacham, Karyopharm Therapeutics, Newton, MA; and Richard Kim and Amit Mahipal, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

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http://dx.doi.org/10.1200/JCO.2015.65.3949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562433PMC
December 2016

A Nuclear Attack on Traumatic Brain Injury: Sequestration of Cell Death in the Nucleus.

CNS Neurosci Ther 2016 Apr 4;22(4):306-15. Epub 2016 Feb 4.

Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

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http://dx.doi.org/10.1111/cns.12501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067638PMC
April 2016

XPO1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal Cancer.

Clin Cancer Res 2016 Apr 24;22(7):1663-73. Epub 2015 Nov 24.

Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts. Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-0978DOI Listing
April 2016

Human Exportin-1 is a Target for Combined Therapy of HIV and AIDS Related Lymphoma.

EBioMedicine 2015 Sep 1;2(9):1102-13. Epub 2015 Aug 1.

KU Leuven, Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ebiom.2015.07.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588406PMC
September 2015

Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.

Sci Rep 2015 Sep 24;5:14391. Epub 2015 Sep 24.

Department of Molecular, Cellular, and Developmental Biology, GOLD A240B, 347 UCB, University of Colorado-Boulder, Boulder, CO 80309 USA.

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http://dx.doi.org/10.1038/srep14391DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585873PMC
September 2015

Therapeutic Potential of Targeting PAK Signaling.

Anticancer Agents Med Chem 2016 ;16(1):75-88

Karyopharm Therapeutics, Inc. Address: 85 Wells Avenue, Newton, Massachusetts, USA, 02459.

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http://dx.doi.org/10.2174/1871520615666150617111414DOI Listing
August 2016

Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing.

Chem Biol 2015 Jan 8;22(1):107-16. Epub 2015 Jan 8.

Department of Microbiology and Immunology, Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven-University of Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2014.11.015DOI Listing
January 2015

Specific inhibition of the nuclear exporter exportin-1 attenuates kidney cancer growth.

PLoS One 2014 2;9(12):e113867. Epub 2014 Dec 2.

Division of Nephrology, Dept. of Internal Medicine, University of California Davis, Davis, California, United States of America; Cancer Center, University of California Davis, Davis, California, United States of America; Medical Service, Sacramento VA Medical Center, Sacramento, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113867PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252068PMC
July 2015

Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.

Am J Physiol Renal Physiol 2014 Dec 18;307(11):F1179-86. Epub 2014 Sep 18.

Graduate Group in Comparative Pathology, Division of Nephrology, Department of Internal Medicine, and Cancer Center, University of California, Davis, California; Medical Service, Sacramento Veterans Affairs Medical Center, Sacramento, California

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http://dx.doi.org/10.1152/ajprenal.00406.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254973PMC
December 2014

Biologic activity of the novel orally bioavailable selective inhibitor of nuclear export (SINE) KPT-335 against canine melanoma cell lines.

BMC Vet Res 2014 Jul 15;10:160. Epub 2014 Jul 15.

Departments of Veterinary Biosciences and Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 1925 Coffey Rd,, Columbus, OH 43210, USA.

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http://bmcvetres.biomedcentral.com/articles/10.1186/1746-614
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http://dx.doi.org/10.1186/1746-6148-10-160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105800PMC
July 2014

Clinical translation of nuclear export inhibitors in cancer.

Semin Cancer Biol 2014 Aug 19;27:74-86. Epub 2014 Apr 19.

Karyopharm Therapeutics, Inc., 2 Mercer Road, Natick, MA 01760, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S1044579X140005
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http://dx.doi.org/10.1016/j.semcancer.2014.04.005DOI Listing
August 2014

XPO1 (CRM1) inhibition represses STAT3 activation to drive a survivin-dependent oncogenic switch in triple-negative breast cancer.

Mol Cancer Ther 2014 Mar 15;13(3):675-86. Epub 2014 Jan 15.

Corresponding Author: Rachel A. Altura, Department of Pediatrics, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3954411PMC
March 2014

CRM1 blockade by selective inhibitors of nuclear export attenuates kidney cancer growth.

J Urol 2013 Jun 16;189(6):2317-26. Epub 2012 Oct 16.

Division of Nephrology, Department of Internal Medicine, University of California-Davis, Davis, California 95616, USA.

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http://dx.doi.org/10.1016/j.juro.2012.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4593314PMC
June 2013

Multiple connexins contribute to intercellular communication in the Xenopus embryo.

J Cell Sci 2003 Jan;116(Pt 1):29-38

Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/jcs.00182DOI Listing
January 2003

Xwnt-2 (Xwnt-2b) is maternally expressed in Xenopus oocytes and embryos.

Biochim Biophys Acta 2002 Jul;1576(3):265-8

Department of Neurobiology, Harvard Medical School, 220 Longwood Ave., Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/s0167-4781(02)00344-5DOI Listing
July 2002