Yoram Vodovotz

Yoram Vodovotz

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Agent-based models of inflammation in translational systems biology: A decade later.

Wiley Interdiscip Rev Syst Biol Med 2019 Nov 1;11(6):e1460. Epub 2019 Jul 1.

Department of Surgery, University of Vermont, Burlington, Vermont.

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https://onlinelibrary.wiley.com/doi/abs/10.1002/wsbm.1460
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http://dx.doi.org/10.1002/wsbm.1460DOI Listing
November 2019

Hepatic Encephalopathy in Children With Acute Liver Failure: Utility of Serum Neuromarkers.

J Pediatr Gastroenterol Nutr 2019 Jul;69(1):108-115

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Pittsburgh School of Medicine, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.

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http://dx.doi.org/10.1097/MPG.0000000000002351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591057PMC
July 2019

Elevations in Circulating sST2 Levels Are Associated With In-hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma.

J Surg Res 2019 Jul 3;244:23-33. Epub 2019 Jul 3.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative, Medicine, Pittsburgh, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2019.05.057DOI Listing
July 2019

Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury.

J Am Coll Surg 2019 Feb 16;228(2):148-160.e7. Epub 2018 Nov 16.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10727515183215
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http://dx.doi.org/10.1016/j.jamcollsurg.2018.10.019DOI Listing
February 2019

Inflammation and Disease: Modelling and Modulation of the Inflammatory Response to Alleviate Critical Illness.

Curr Opin Syst Biol 2018 Dec 23;12:22-29. Epub 2018 Aug 23.

McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA.

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http://dx.doi.org/10.1016/j.coisb.2018.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420220PMC
December 2018

Rationale and design of technology assisted stepped collaborative care intervention to improve patient-centered outcomes in hemodialysis patients (TĀCcare trial).

Contemp Clin Trials 2018 10 9;73:81-91. Epub 2018 Sep 9.

Renal and Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cct.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168366PMC
October 2018

Prospective Analyses of Cytokine Mediation of Sleep and Survival in the Context of Advanced Cancer.

Psychosom Med 2018 06;80(5):483-491

From the Departments of Surgery, Psychiatry, and Psychology (Steel), Occupational Therapy (Terhorst), Surgery, Mathematica Policy Research (Collins), Surgery (Geller, Vodovotz, Kim, Krane, Marsh, Tsung), University of Pittsburg, Pennsylvania; Department of Psychology (Antoni), University of Miami, Florida; School of Nursing (Burke), and Department of Medicine, Surgery and Immunology (Butterfield), University of Pittsburgh, Pennsylvania; Department of Medical Social Sciences, Psychology, and Psychiatry and Behavioral Sciences (Penedo), Northwestern University, Evantson, Illinois; and Department of Psychiatry (Buysse), University of Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/PSY.0000000000000579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976532PMC
June 2018

What's New in Shock, June 2018?

Shock 2018 06;49(6):613-615

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/SHK.0000000000001130DOI Listing
June 2018

IL-17A - A regulator in acute inflammation: Insights from in vitro, in vivo and in silico studies.

Cytokine 2018 Jun 25. Epub 2018 Jun 25.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.03.030DOI Listing
June 2018

Suppressed networks of inflammatory mediators characterize chronic venous insufficiency.

J Vasc Surg Venous Lymphat Disord 2018 05 10;6(3):358-366. Epub 2018 Feb 10.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pa.

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http://dx.doi.org/10.1016/j.jvsv.2017.11.009DOI Listing
May 2018

Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma.

J Orthop Trauma 2018 Mar;32 Suppl 1:S1-S6

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA.

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http://Insights.ovid.com/crossref?an=00005131-201803003-0000
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http://dx.doi.org/10.1097/BOT.0000000000001114DOI Listing
March 2018

Inflammatory Mediators Associated With Pressure Ulcer Development in Individuals With Pneumonia After Traumatic Spinal Cord Injury: A Pilot Study.

Arch Phys Med Rehabil 2017 09 25;98(9):1792-1799. Epub 2017 Jan 25.

Department of Rehabilitation Science and Technology, University of Pittsburgh, Pittsburgh, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.

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https://linkinghub.elsevier.com/retrieve/pii/S00039993173002
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http://dx.doi.org/10.1016/j.apmr.2016.12.018DOI Listing
September 2017

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure.

J Trauma Acute Care Surg 2017 09;83(3):520-531

From the Acute Care Surgery division (F.A.M., L.L.M.), University of Florida, Gainesville, Florida; Department of Surgery (E.E.M., A.B.), Denver Health, University of Colorado, Denver, Colorado; and Department of Surgery (T.R.B., Y.V.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573617PMC
September 2017

Differential inflammatory networks distinguish responses to bone marrow-derived versus adipose-derived mesenchymal stem cell therapies in vascularized composite allotransplantation.

J Trauma Acute Care Surg 2017 07;83(1 Suppl 1):S50-S58

From the Department of Surgery (R.Z., Y.V.), Department of Plastic Surgery (S.K.R., V.S.G.), University of Pittsburgh, Pittsburgh, Pennsylvania; Division of Plastic Surgery and Hand Surgery (J.A.P., V.S.G.), University Hospital Zurich, Zurich, Switzerland; and Center for Inflammation and Regenerative Modeling (Y.V.), McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000001489DOI Listing
July 2017

Time for trauma immunology.

PLoS Med 2017 Jul 11;14(7):e1002342. Epub 2017 Jul 11.

Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pmed.1002342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5507395PMC
July 2017

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients.

Mediators Inflamm 2016 15;2016:7950374. Epub 2016 Nov 15.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1155/2016/7950374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126463PMC
May 2017

Reverse Engineering the Inflammatory "Clock": From Computational Modeling to Rational Resetting.

Authors:
Yoram Vodovotz

Drug Discov Today Dis Models 2016 15;22:57-63. Epub 2017 Apr 15.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213.

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http://dx.doi.org/10.1016/j.ddmod.2017.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764194PMC
April 2017

Solving Immunology?

Trends Immunol 2017 02 13;38(2):116-127. Epub 2016 Dec 13.

Center for Advanced Research on Diagnostic Assays, Immunology Institute, Friedman Brain Institute, and Departments of Neurology, Neuroscience, Pharmacology, and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.it.2016.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695553PMC
February 2017

Data-Driven Modeling for Precision Medicine in Pediatric Acute Liver Failure.

Mol Med 2017 Jan 23;22:821-829. Epub 2016 Nov 23.

Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA 15213.

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http://dx.doi.org/10.2119/molmed.2016.00183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5263056PMC
January 2017

Individual-specific principal component analysis of circulating inflammatory mediators predicts early organ dysfunction in trauma patients.

J Crit Care 2016 12 11;36:146-153. Epub 2016 Jul 11.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15213; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097026PMC
December 2016

From static to dynamic: a sepsis-specific dynamic model from clinical criteria in polytrauma patients.

Ann Transl Med 2016 Dec;4(24):492

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; ; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.21037/atm.2016.11.72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233511PMC
December 2016

Computational Analysis Supports an Early, Type 17 Cell-Associated Divergence of Blunt Trauma Survival and Mortality.

Crit Care Med 2016 Nov;44(11):e1074-e1081

1Department of Surgery, University of Pittsburgh, Pittsburgh, PA. 2Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA. 3Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA. 4Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. 5Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI. 6Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA.

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http://dx.doi.org/10.1097/CCM.0000000000001951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5201164PMC
November 2016

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients.

Front Pharmacol 2016 1;7:383. Epub 2016 Nov 1.

Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of PittsburghPittsburgh, PA, USA; Department of Surgery, University of PittsburghPittsburgh, PA, USA.

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http://dx.doi.org/10.3389/fphar.2016.00383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5088435PMC
November 2016

Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks.

Front Pharmacol 2016 4;7:413. Epub 2016 Nov 4.

Department of Surgery, University of Pittsburgh, PittsburghPA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, PittsburghPA, USA.

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http://dx.doi.org/10.3389/fphar.2016.00413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095594PMC
November 2016

Early Detection of Pressure Ulcer Development Following Traumatic Spinal Cord Injury Using Inflammatory Mediators.

Arch Phys Med Rehabil 2016 10 25;97(10):1656-62. Epub 2016 Jan 25.

Department of Rehabilitation Science and Technology, School of Health and Rehabilitation Science, University of Pittsburgh, Pittsburgh, PA; Human Engineering Research Laboratories, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA; Department of Mathematics, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1016/j.apmr.2016.01.003DOI Listing
October 2016

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective.

Ann Biomed Eng 2016 09 25;44(9):2611-25. Epub 2016 Mar 25.

Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Sciences Tower, 200 Lothrop St., Pittsburgh, PA, 15213, USA.

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http://dx.doi.org/10.1007/s10439-016-1596-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983470PMC
September 2016

Precision Medicine for Critical Illness and Injury.

Crit Care Med 2016 09;44(9):1635-8

Emory UniversityUniversity of PittsburghUniformed Services University of the Health SciencesDuke UniversityEmory UniversityUniversity of PittsburghEmory University.

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http://dx.doi.org/10.1097/CCM.0000000000002028DOI Listing
September 2016

Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death.

Front Pharmacol 2016 27;7:342. Epub 2016 Sep 27.

Department of Surgery, University of PittsburghPittsburgh, PA, USA; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of PittsburghPittsburgh, PA, USA.

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http://dx.doi.org/10.3389/fphar.2016.00342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5037938PMC
September 2016

Temporal Patterns of Circulating Inflammation Biomarker Networks Differentiate Susceptibility to Nosocomial Infection Following Blunt Trauma in Humans.

Ann Surg 2016 Jan;263(1):191-8

*Department of Surgery, University of Pittsburgh, Pittsburgh, PA †Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA ‡Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA §Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA ¶Department of Internal Medicine, Division of Rheumatology, Wayne State University, Detroit, MI ||Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SLA.0000000000001001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136774PMC
January 2016

Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling.

Front Immunol 2015 20;6:587. Epub 2015 Nov 20.

Department of Surgery, University of Pittsburgh , Pittsburgh, PA , USA ; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, PA , USA.

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http://dx.doi.org/10.3389/fimmu.2015.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653302PMC
December 2015

Mathematical Modeling of Early Cellular Innate and Adaptive Immune Responses to Ischemia/Reperfusion Injury and Solid Organ Allotransplantation.

Front Immunol 2015 25;6:484. Epub 2015 Sep 25.

Department of Surgery, University of Pittsburgh , Pittsburgh, PA , USA ; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine , Pittsburgh, PA , USA.

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http://dx.doi.org/10.3389/fimmu.2015.00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585194PMC
October 2015

Impact of Injury Severity on Dynamic Inflammation Networks Following Blunt Trauma.

Shock 2015 Aug;44(2):101-9

*Department of Surgery and †Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, and ‡Department of Critical Care Medicine, University of Pittsburgh, Pennsylvania.

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http://pdfs.journals.lww.com/shockjournal/2015/08000/Impact_
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SHK.0000000000000395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504837PMC
August 2015

Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans.

Crit Care Med 2015 Jul;43(7):1395-404

1Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA. 2Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA. 3Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. 4Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

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https://insights.ovid.com/crossref?an=00003246-201507000-000
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http://dx.doi.org/10.1097/CCM.0000000000000964DOI Listing
July 2015

In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain.

J Neuroimmunol 2015 Jun 28;283:43-9. Epub 2015 Apr 28.

Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jneuroim.2015.04.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465386PMC
June 2015

Impact of chemically-modified tetracycline 3 on intertwined physiological, biochemical, and inflammatory networks in porcine sepsis/ARDS.

Int J Burns Trauma 2015 20;5(1):22-35. Epub 2015 Mar 20.

Department of Surgery, University of Pittsburgh Pittsburgh, PA, USA ; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh Pittsburgh, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448085PMC
June 2015

A Computational, Tissue-Realistic Model of Pressure Ulcer Formation in Individuals with Spinal Cord Injury.

PLoS Comput Biol 2015 Jun 25;11(6):e1004309. Epub 2015 Jun 25.

Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America; Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482429PMC
June 2015

Insights from computational modeling in inflammation and acute rejection in limb transplantation.

PLoS One 2014 13;9(6):e99926. Epub 2014 Jun 13.

Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University, Innsbruck, Austria; Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099926PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057425PMC
May 2015

Myocyte TLR4 enhances enteric and systemic inflammation driving late murine endotoxic ileus.

Am J Physiol Gastrointest Liver Physiol 2015 May 6;308(10):G852-62. Epub 2015 Mar 6.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Physiology and Pharmacology, Liberty University College of Osteopathic Medicine, Lynchburg, Virginia

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http://www.physiology.org/doi/10.1152/ajpgi.00211.2014
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http://dx.doi.org/10.1152/ajpgi.00211.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437022PMC
May 2015

Innate immunity in disease: insights from mathematical modeling and analysis.

Adv Exp Med Biol 2014 ;844:227-43

University of Pittsburgh, 3064 Biomedical Sciences Tower 3, 3501 Fifth Ave., 15213, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1007/978-1-4939-2095-2_11DOI Listing
April 2015

Trauma in silico: Individual-specific mathematical models and virtual clinical populations.

Sci Transl Med 2015 Apr;7(285):285ra61

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa3636DOI Listing
April 2015

The early evolving sex hormone environment is associated with significant outcome and inflammatory response differences after injury.

J Trauma Acute Care Surg 2015 Mar;78(3):451-7; discussion 457-8

From the Division of Trauma and General Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/TA.0000000000000550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340085PMC
March 2015

Predicting in vivo responses to biomaterials via combined in vitro and in silico analysis.

Tissue Eng Part C Methods 2015 Feb 4;21(2):148-59. Epub 2014 Aug 4.

1 Department of Bioengineering, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/ten.TEC.2014.0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313398PMC
February 2015

Injury-induced MRP8/MRP14 stimulates IP-10/CXCL10 in monocytes/macrophages.

FASEB J 2015 Jan 23;29(1):250-62. Epub 2014 Oct 23.

State Key Laboratory of Organ Failure Research, Key Laboratory of Transcriptomics and Proteomics, Ministry of Education of China, Key Laboratory of Proteomics of Guangdong Province, Southern Medical University, Guangzhou, China;

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http://dx.doi.org/10.1096/fj.14-255992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285539PMC
January 2015

Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses.

J Theor Biol 2014 Oct 5;358:132-48. Epub 2014 Jun 5.

Immunetrics, Inc., Pittsburgh, PA 15203, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jtbi.2014.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4125477PMC
October 2014

Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience.

Authors:
Yoram Vodovotz

Interface Focus 2014 Oct;4(5):20140004

Department of Surgery , University of Pittsburgh , W944 Starzl Biomedical Sciences Tower, 200 Lothrop Street, Pittsburgh, PA 15213 , USA.

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http://dx.doi.org/10.1098/rsfs.2014.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142014PMC
October 2014

Delayed neutralization of interleukin 6 reduces organ injury, selectively suppresses inflammatory mediator, and partially normalizes immune dysfunction following trauma and hemorrhagic shock.

Shock 2014 Sep;42(3):218-27

*Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and †Department of General Surgery, Union Hospital, Huazhong University of Science and Technology, China.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SHK.0000000000000211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134434PMC
September 2014

Central role for MCP-1/CCL2 in injury-induced inflammation revealed by in vitro, in silico, and clinical studies.

PLoS One 2013 3;8(12):e79804. Epub 2013 Dec 3.

Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America ; Department of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America ; Joint Carnegie Mellon University - University of Pittsburgh Ph.D. Program in Computational Biology, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079804PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849193PMC
August 2014

From data patterns to mechanistic models in acute critical illness.

J Crit Care 2014 Aug 29;29(4):604-10. Epub 2014 Mar 29.

Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219. Electronic address:

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http://dx.doi.org/10.1016/j.jcrc.2014.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074505PMC
August 2014

A Multiscale Agent-Based in silico Model of Liver Fibrosis Progression.

Front Bioeng Biotechnol 2014 30;2:18. Epub 2014 May 30.

Department of Surgery, University of Pittsburgh , Pittsburgh, PA , USA ; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, PA , USA.

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http://d-scholarship.pitt.edu/24764/1/fbioe-02-00018.pdf
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http://journal.frontiersin.org/article/10.3389/fbioe.2014.00
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http://dx.doi.org/10.3389/fbioe.2014.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126446PMC
August 2014

Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure.

PLoS One 2013 11;8(11):e78202. Epub 2013 Nov 11.

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America ; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America ; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078202PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823926PMC
July 2014

How implementation of systems biology into clinical trials accelerates understanding of diseases.

Front Neurol 2014 27;5:102. Epub 2014 Jun 27.

Stroke Branch, National Institute of Neurological Disorder and Stroke, National Institutes of Health , Bethesda, MD , USA.

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http://dx.doi.org/10.3389/fneur.2014.00102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073421PMC
July 2014

Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma.

Crit Care Med 2014 Jun;42(6):1487-97

1Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. 2Department of Surgery, University of Pittsburgh, Pittsburgh, PA. 3Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA. 4Department of Sports Medicine and Nutrition, University of Pittsburgh, Pittsburgh, PA. 5Department of Rehabilitation Science and Technology, University of Pittsburgh, Pittsburgh, PA. 6Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.

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http://dx.doi.org/10.1097/CCM.0000000000000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133186PMC
June 2014

Identification of distinct monocyte phenotypes and correlation with circulating cytokine profiles in acute response to spinal cord injury: a pilot study.

PM R 2014 Apr 17;6(4):332-41. Epub 2013 Oct 17.

Department of Physical Medicine and Rehabilitation, 3471 5th Ave, Suite 201, University of Pittsburgh, Pittsburgh, PA 15213; The Ferguson Laboratory for Orthopaedic Research, Department of Orthopaedic Surgery, University of Pittsburgh, PA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA(‡‡). Electronic address:

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http://dx.doi.org/10.1016/j.pmrj.2013.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990657PMC
April 2014

Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies.

Shock 2014 Apr;41(4):317-23

*Department of Surgery, SUNY Upstate University, Syracuse, New York; Departments of †Surgery and ‡Computational and Systems Biology, University of Pittsburgh, Pennsylvania; §Department of Biologic Sciences, SUNY Cortland, Cortland, New York; ∥Department of Surgery, University of Chicago, Chicago, Illinois; and ¶Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1097/SHK.0000000000000121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962670PMC
April 2014

Abstract 102: inflammatory mediators modulate alloreactive T cell susceptibility to immune-regulation in reconstructive transplantation.

Plast Reconstr Surg 2014 Mar;133(3 Suppl):117

1Johns Hopkins University School of Medicine, Dept of Plastic & Reconstructive Surgery, Baltimore, MD, 2University of Pittsburgh Medical Center, Starzl Transplantation Institute, Pittsburgh, PA, 3Language Technologies Institute, Carnegie Mellon University, Pittsburgh, PA.

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http://dx.doi.org/10.1097/01.prs.0000444926.53453.9fDOI Listing
March 2014

The central role of arginine catabolism in T-cell dysfunction and increased susceptibility to infection after physical injury.

Ann Surg 2014 Jan;259(1):171-8

Departments of *Surgery †Departments of Microbiology, Immunology, and Parasitology, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA. ‡Immunology §Microbiology and Molecular Genetics ¶Critical Care Medicine, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA; and ‖Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine.

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http://dx.doi.org/10.1097/SLA.0b013e31828611f8DOI Listing
January 2014

Nitric oxide, a protective molecule in the cardiovascular system.

Nitric Oxide 2013 Nov 1;35:175-85. Epub 2013 Oct 1.

Department of Surgery, University of Pittsburgh, United States. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2013.09.004DOI Listing
November 2013

Computational Modeling of Inflammation and Wound Healing.

Adv Wound Care (New Rochelle) 2013 Nov;2(9):527-537

Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh , Pittsburgh, Pennsylvania. ; Department of Surgery, University of Pittsburgh , Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/wound.2012.0416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816782PMC
November 2013

A Systems Engineering Perspective on Homeostasis and Disease.

Front Bioeng Biotechnol 2013 9;1. Epub 2013 Sep 9.

Department of Biomedical Engineering, Rutgers University , Piscataway, NJ , USA ; Department of Chemical and Biochemical Engineering, Rutgers University , Piscataway, NJ , USA ; Department of Surgery, Rutgers Robert Wood Johnson Medical School , New Brunswick, NJ , USA.

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http://dx.doi.org/10.3389/fbioe.2013.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090890PMC
September 2013

In silico modeling: methods and applications to trauma and sepsis.

Crit Care Med 2013 Aug;41(8):2008-14

Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA.

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http://dx.doi.org/10.1097/CCM.0b013e31829a6eb4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722589PMC
August 2013

Age-independent co-expression of antimicrobial gene clusters in the blood of septic patients.

Int J Antimicrob Agents 2013 Jun 15;42 Suppl:S2-7. Epub 2013 May 15.

Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany.

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http://dx.doi.org/10.1016/j.ijantimicag.2013.04.012DOI Listing
June 2013

Therapeutic strategies in inflammasome mediated diseases of the liver.

J Hepatol 2013 May 21;58(5):1047-52. Epub 2012 Dec 21.

Section of Digestive Diseases, Yale University, and West Haven Veterans Medical Center, New Haven, CT, United States.

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http://dx.doi.org/10.1016/j.jhep.2012.12.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113326PMC
May 2013

A three-dimensional mathematical and computational model of necrotizing enterocolitis.

J Theor Biol 2013 Apr 7;322:17-32. Epub 2012 Dec 7.

Department of Mathematics, 301 Thackeray Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00225193120059
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http://dx.doi.org/10.1016/j.jtbi.2012.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646071PMC
April 2013

The effects of ingested mammalian blood factors on vector arthropod immunity and physiology.

Microbes Infect 2013 Mar 28;15(3):243-54. Epub 2013 Jan 28.

Department of Medical Microbiology and Immunology, University of California, Davis, CA 95616, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S12864579130001
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http://dx.doi.org/10.1016/j.micinf.2013.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602389PMC
March 2013

Sepsis: from pattern to mechanism and back.

Crit Rev Biomed Eng 2012 ;40(4):341-51

Department of Surgery, University of Chicago, Chicago, IL 60637, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3623270PMC
January 2013

Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling.

Front Physiol 2012 2;3:222. Epub 2012 Jul 2.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Case Western Reserve University Cleveland, OH, USA.

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http://dx.doi.org/10.3389/fphys.2012.00222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387781PMC
October 2012

Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO.

J Immunol 2012 Oct 7;189(8):3848-58. Epub 2012 Sep 7.

Department of Surgery, Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

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http://dx.doi.org/10.4049/jimmunol.1200819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466356PMC
October 2012

A Biohybrid Device for the Systemic Control of Acute Inflammation.

Disrupt Sci Technol 2012 May;1(1)

Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania. ; Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

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http://dx.doi.org/10.1089/dst.2012.0001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3817839PMC
May 2012