Yoon-Sim Yap

Yoon-Sim Yap

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Yoon-Sim Yap

Yoon-Sim Yap

Publications by authors named "Yoon-Sim Yap"

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52Publications

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Response to Sung, Rosenberg, and Yang.

J Natl Cancer Inst 2019 Sep 23. Epub 2019 Sep 23.

National Taiwan University Hospital, Taipei, Taiwan.

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http://dx.doi.org/10.1093/jnci/djz191DOI Listing
September 2019

Assessment of PARP4 as a candidate breast cancer susceptibility gene.

Breast Cancer Res Treat 2019 Aug 22;177(1):145-153. Epub 2019 May 22.

Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore.

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http://dx.doi.org/10.1007/s10549-019-05286-wDOI Listing
August 2019

Patterns of relapse after neoadjuvant chemotherapy in breast cancer: implications for surveillance in clinical practice.

Breast Cancer Res Treat 2019 Aug 30;177(1):197-206. Epub 2019 May 30.

Division of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Singapore, 169610, Singapore.

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http://dx.doi.org/10.1007/s10549-019-05290-0DOI Listing
August 2019

Insights Into Breast Cancer in the East vs the West: A Review.

JAMA Oncol 2019 May 16. Epub 2019 May 16.

Department of Haematology-Oncology, National University Cancer Institute, Singapore.

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2019.0620DOI Listing
May 2019

Elucidating therapeutic molecular targets in premenopausal Asian women with recurrent breast cancers.

NPJ Breast Cancer 2018 26;4:19. Epub 2018 Jul 26.

3Oncology Next-Generation Diagnostics, Novartis Institutes for Biomedical Research, Cambridge, USA.

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http://dx.doi.org/10.1038/s41523-018-0070-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062514PMC
July 2018

Genotype-Phenotype Correlation in NF1: Evidence for a More Severe Phenotype Associated with Missense Mutations Affecting NF1 Codons 844-848.

Am J Hum Genet 2018 01 28;102(1):69-87. Epub 2017 Dec 28.

Department of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777934PMC
January 2018

Identification of Novel Breast Cancer Risk Loci.

Cancer Res 2017 10 3;77(19):5428-5437. Epub 2017 Aug 3.

Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1158/0008-5472.CAN-17-0992DOI Listing
October 2017

Outcome after neoadjuvant chemotherapy in Asian breast cancer patients.

Cancer Med 2017 01 20;6(1):173-185. Epub 2016 Dec 20.

Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, Singapore, 117549, Singapore.

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http://dx.doi.org/10.1002/cam4.985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5269707PMC
January 2017

Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer.

N Engl J Med 2016 11 7;375(18):1738-1748. Epub 2016 Oct 7.

From the University of Texas M.D. Anderson Cancer Center, Houston (G.N.H.), and Texas Oncology-Baylor Charles A. Sammons Cancer Center and the U.S. Oncology Network, Dallas (J.O.) - all in Texas; Davidoff Center, Rabin Medical Center, Tel Aviv University, Tel Aviv (S.M.S.), and Sheba Medical Center, Ramat Gan (S.P.-S.) - both in Israel; the Sarah Cannon Research Institute (H.A.B., D.Y.), Vanderbilt-Ingram Cancer Center (C.L.A.), and Tennessee Oncology (D.Y.) - all in Nashville; National Cancer Center Singapore, Singapore (Y.-S.Y.); Netherlands Cancer Institute and BOOG Study Center, Amsterdam (G.S.S.); Institut de Cancérologie de l'Ouest/René Gauducheau, Saint-Herblain (M.C.), Institut Gustave Roussy, Université Paris Sud, Villejuif (F.A.), University Hospital of Besançon, Besançon (C.V.), and Centre Léon Bérard, Lyon (T.B.) - all in France; Duke University Medical Center, Durham, NC (K.L.B.); Dana-Farber Cancer Institute, Boston (E.P.W.); University of Ulm, Ulm (W.J.), Onkologische Praxis, Velbert (A.N.), University of Tübingen, Tübingen (E.-M.G.), and Joint Practice for Interdisciplinary Oncology and Hematology, Freiburg (N.M.) - all in Germany; Tom Baker Cancer Centre, Calgary, AB, Canada (S.V.); University of Padua and Istituto Oncologico Veneto, Istituto di Ricovero e Cura a Carattere Scientifico, Padua, Italy (P.C.); Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh (D.A.C.); Masaryk Memorial Cancer Institute, Brno, Czech Republic (K.P.); Florida Cancer Specialists-Sarah Cannon Research Institute, Fort Myers (L.L.H.); Breast Cancer Research Centre-Western Australia and Curtin University, Perth, Australia (A.C.); Department of Oncology, Vejle Hospital, Vejle, Denmark (E.J.); Arkhangelsk Clinical Oncology Dispensary, Arkhangelsk, Russia (O.B.); Hospital Universitario Virgen de la Victoria, Institute of Biomedical Research in Málaga, Málaga, Spain (E.A.); Oslo University Hospital, Oslo (E.W.); Virginia Cancer Specialists, Arlington (A.M.F.); Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan (L.-M.T.); Rainier Hematology-Oncology, Northwest Medical Specialties, Puyallup, WA (S.B.); Novartis Pharmaceuticals, East Hanover, NJ (F.X., M.M., C.G., S.H.); and Novartis Pharma, Basel, Switzerland (F.S.).

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http://dx.doi.org/10.1056/NEJMoa1609709DOI Listing
November 2016

Predictive Factors for BRCA1 and BRCA2 Genetic Testing in an Asian Clinic-Based Population.

PLoS One 2015 29;10(7):e0134408. Epub 2015 Jul 29.

Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore; Department of Physiology, Yong Yoo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134408PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4519264PMC
May 2016

Patient Management with Eribulin in Metastatic Breast Cancer: A Clinical Practice Guide.

J Breast Cancer 2016 Mar 25;19(1):8-17. Epub 2016 Mar 25.

Department of Medical Oncology, National Cancer Centre Singapore, Singapore.

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http://dx.doi.org/10.4048/jbc.2016.19.1.8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822111PMC
March 2016

Brain-derived neurotrophic factor genetic polymorphism (rs6265) is protective against chemotherapy-associated cognitive impairment in patients with early-stage breast cancer.

Neuro Oncol 2016 Feb 19;18(2):244-51. Epub 2015 Aug 19.

Department of Pharmacy, National University of Singapore, Singapore (T.N., S.M.T., H.L.Y., M.S., Y.T.C., H.K.H., A.C.); Department of Pharmacy, National Cancer Centre Singapore, Singapore (Y.X.G., A.C.); Department of Pharmacy, K.K. Women's and Children's Hospital, Singapore (K.M.F.); Breast Centre, K.K. Women's and Children's Hospital, Singapore (M.T.C., J.A.L.); Department of Psychosocial Oncology, National Cancer Centre Singapore, Singapore (Y.P.T., G.F.); Department of Surgical Oncology, National Cancer Centre Singapore, Singapore (W.S.Y., M.P.); Department of Medical Oncology, National Cancer Centre Singapore, Singapore (W.-J.K.L., S.-L.K., A.J., G.E.L., M.W., R.D., Y.S.Y., R.N.); Duke-N.U.S Graduate Medical School Singapore, Singapore (R.D., R.N.); Human Genetics, Genome Institute of Singapore, Singapore (C.C.K.); Singapore Eye Research Institute, Singapore (C.C.K.).

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http://dx.doi.org/10.1093/neuonc/nov162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724179PMC
February 2016

Inherited breast cancer predisposition in Asians: multigene panel testing outcomes from Singapore.

NPJ Genom Med 2016 13;1:15003. Epub 2016 Jan 13.

Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore.

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http://dx.doi.org/10.1038/npjgenmed.2015.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685290PMC
January 2016

PI3K/Akt/mTOR inhibitors in breast cancer.

Cancer Biol Med 2015 Dec;12(4):342-54

Department of Medical Oncology, National Cancer Center Singapore, Singapore 169610, Singapore.

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http://dx.doi.org/10.7497/j.issn.2095-3941.2015.0089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706528PMC
December 2015

Clinical validation of an ultra high-throughput spiral microfluidics for the detection and enrichment of viable circulating tumor cells.

PLoS One 2014 7;9(7):e99409. Epub 2014 Jul 7.

Mechanobiology Institute, National University of Singapore, Singapore, Singapore; BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore; Clearbridge BioMedics Pte Ltd, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085042PMC
November 2015

The NF1 gene revisited - from bench to bedside.

Oncotarget 2014 Aug;5(15):5873-92

Cancer Therapeutics Laboratory, Centre for Personalised Cancer Medicine, University of Adelaide, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171599PMC
http://dx.doi.org/10.18632/oncotarget.2194DOI Listing
August 2014

Minimal clinically important difference (MCID) for the functional assessment of cancer therapy: cognitive function (FACT-Cog) in breast cancer patients.

J Clin Epidemiol 2014 Jul 18;67(7):811-20. Epub 2014 Mar 18.

Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore 117543; Department of Pharmacy, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610. Electronic address:

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http://dx.doi.org/10.1016/j.jclinepi.2013.12.011DOI Listing
July 2014

An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells.

Analyst 2014 Jul;139(13):3245-55

BioSystems and Micromechanics (BioSyM) IRG, Singapore-MIT Alliance for Research and Technology (SMART) Centre, Singapore.

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http://dx.doi.org/10.1039/c4an00355aDOI Listing
July 2014

Improving indel detection specificity of the Ion Torrent PGM benchtop sequencer.

PLoS One 2012 19;7(9):e45798. Epub 2012 Sep 19.

Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0045798PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446914PMC
February 2013

Effect of CYP3A4 inducer dexamethasone on hepatotoxicity of lapatinib: clinical and in vitro evidence.

Breast Cancer Res Treat 2012 Jun 28;133(2):703-11. Epub 2012 Feb 28.

Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore, Singapore.

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http://link.springer.com/10.1007/s10549-012-1995-7
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http://dx.doi.org/10.1007/s10549-012-1995-7DOI Listing
June 2012

Time trends in the outcome of elderly patients with breast cancer.

Breast J 2008 Mar-Apr;14(2):158-63. Epub 2008 Feb 25.

The Royal Marsden Hospital, Surrey, United Kingdom.

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http://dx.doi.org/10.1111/j.1524-4741.2007.00547.xDOI Listing
April 2008

A phase II study of weekly docetaxel in patients with anthracycline pretreated metastatic breast cancer.

Cancer Chemother Pharmacol 2006 Dec 10;58(6):809-15. Epub 2006 Mar 10.

Department of Medicine, Breast Unit, Royal Marsden NHS Trust, 233 Fulham Road, SW3 6JJ, London, United Kingdom.

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http://dx.doi.org/10.1007/s00280-006-0222-9DOI Listing
December 2006

Lymphomatous infiltration of the peripheral nervous system in enteropathy-associated T-cell lymphoma.

Med J Aust 2005 Apr;182(7):348-9

Medical Oncology Register, The Queen Elizabeth Hospital, Adelaide, South Australia.

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April 2005