Yongzhang Luo

Yongzhang Luo

UNVERIFIED PROFILE

Are you Yongzhang Luo?   Register this Author

Register author
Yongzhang Luo

Yongzhang Luo

Publications by authors named "Yongzhang Luo"

Are you Yongzhang Luo?   Register this Author

69Publications

1428Reads

26Profile Views

Metformin Inhibits Tumor Metastasis through Suppressing Hsp90α Secretion in an AMPKα1-PKCγ Dependent Manner.

Cells 2020 Jan 7;9(1). Epub 2020 Jan 7.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/cells9010144DOI Listing
January 2020

Pharmacokinetics of PEGylated recombinant human endostatin in rhesus monkeys.

Life Sci 2019 Dec 15;238:116967. Epub 2019 Oct 15.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, 100084, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lfs.2019.116967DOI Listing
December 2019

Biophysical and biological characterization of PEGylated recombinant human endostatin.

Clin Exp Pharmacol Physiol 2019 Oct 30;46(10):920-927. Epub 2019 Jul 30.

National Engineering Laboratory for Anti-tumour Protein Therapeutics, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1440-1681.13134DOI Listing
October 2019

A novel pan-cancer biomarker plasma heat shock protein 90alpha and its diagnosis determinants in clinic.

Cancer Sci 2019 Sep 9;110(9):2941-2959. Epub 2019 Aug 9.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.14143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6726694PMC
September 2019

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

J Cell Sci 2019 07 31;132(15). Epub 2019 Jul 31.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Beijing, Haidian district, 100084, China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/jcs.228213DOI Listing
July 2019

High expression of CCR5 in melanoma enhances epithelial-mesenchymal transition and metastasis via TGFβ1.

J Pathol 2019 04 16;247(4):481-493. Epub 2019 Jan 16.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.5207DOI Listing
April 2019

Lysyl Oxidase-Like Protein 2 Promotes Tumor Lymphangiogenesis and Lymph Node Metastasis in Breast Cancer.

Neoplasia 2019 04 27;21(4):413-427. Epub 2019 Mar 27.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics; Beijing Key Laboratory for Protein Therapeutics; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neo.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439287PMC
April 2019

Quality, bioactivity study, and preclinical acute toxicity, safety pharmacology evaluation of PEGylated recombinant human endostatin (M ES).

J Biochem Mol Toxicol 2019 Mar 10;33(3):e22257. Epub 2018 Dec 10.

National Engineering Laboratory for Anti-Tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbt.22257DOI Listing
March 2019

Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.

J Exp Clin Cancer Res 2019 Feb 11;38(1):66. Epub 2019 Feb 11.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13046-019-1053-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371491PMC
February 2019

CXCR7 promotes melanoma tumorigenesis via Src kinase signaling.

Cell Death Dis 2019 02 25;10(3):191. Epub 2019 Feb 25.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41419-019-1442-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389959PMC
February 2019

A pre-clinical safety study of PEGylated recombinant human endostatin (MES) in Sprague Dawley rats.

Regul Toxicol Pharmacol 2018 Jun 24;95:190-197. Epub 2018 Mar 24.

National Center for Safety Evaluation of Drugs, National Institute for Food and Drug Control, Beijing 100176, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yrtph.2018.03.017DOI Listing
June 2018

Lung fibroblasts promote metastatic colonization through upregulation of stearoyl-CoA desaturase 1 in tumor cells.

Oncogene 2018 03 12;37(11):1519-1533. Epub 2018 Jan 12.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-017-0062-6DOI Listing
March 2018

Endostatin sensitizes p53-deficient non-small-cell lung cancer to genotoxic chemotherapy by targeting DNA-dependent protein kinase catalytic subunit.

J Pathol 2017 10;243(2):255-266

The National Engineering Laboratory for Anti-Tumour Protein Therapeutics, Tsinghua University, Beijing, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4952DOI Listing
October 2017

Plasma Heat Shock Protein 90alpha as a Biomarker for the Diagnosis of Liver Cancer: An Official, Large-scale, and Multicenter Clinical Trial.

EBioMedicine 2017 Oct 12;24:56-63. Epub 2017 Sep 12.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, People's Republic of China; Beijing Key Laboratory for Protein Therapeutics, Tsinghua University, Beijing, People's Republic of China; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, People's Republic of China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2017.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652007PMC
October 2017

E-M, an Engineered Endostatin with High ATPase Activity, Inhibits the Recruitment and Alternative Activation of Macrophages in Non-small Cell Lung Cancer.

Front Pharmacol 2017 9;8:532. Epub 2017 Aug 9.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua UniversityBeijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2017.00532DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552665PMC
August 2017

Adrenomedullin promotes the growth of pancreatic ductal adenocarcinoma through recruitment of myelomonocytic cells.

Oncotarget 2016 Aug;7(34):55043-55056

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.10393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342400PMC
August 2016

Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog.

Chin J Cancer 2016 Jan 20;35:14. Epub 2016 Jan 20.

The National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, 100084, P. R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40880-016-0080-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4721152PMC
January 2016

Endostatin inhibits the tumorigenesis of hemangioendothelioma via downregulation of CXCL1.

Mol Carcinog 2015 Nov 30;54(11):1340-53. Epub 2014 Aug 30.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/mc.22210DOI Listing
November 2015

Tumor cell-secreted angiogenin induces angiogenic activity of endothelial cells by suppressing miR-542-3p.

Cancer Lett 2015 Nov 10;368(1):115-125. Epub 2015 Aug 10.

The National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2015.07.036DOI Listing
November 2015

Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling.

J Pathol 2015 Oct 15;237(2):190-202. Epub 2015 Jun 15.

The National Engineering Laboratory for Anti-Tumour Protein Therapeutics, Tsinghua University, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4564DOI Listing
October 2015

Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis.

Diabetes 2015 Jul 20;64(7):2442-56. Epub 2015 Jan 20.

National Engineering Laboratory of Anti-tumor Protein Therapeutics, Beijing Key Laboratory of Protein Therapeutics, and Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2337/db14-0528DOI Listing
July 2015

The miR-30 Family Inhibits Pulmonary Vascular Hyperpermeability in the Premetastatic Phase by Direct Targeting of Skp2.

Clin Cancer Res 2015 Jul 25;21(13):3071-80. Epub 2015 Mar 25.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing, China. Beijing Key Laboratory for Protein Therapeutics, Beijing, China. Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-14-2785DOI Listing
July 2015

Nuclear-translocated endostatin downregulates hypoxia inducible factor-1α activation through interfering with Zn(II) homeostasis.

Mol Med Rep 2015 May 19;11(5):3473-80. Epub 2015 Jan 19.

National Engineering Laboratory for Anti‑Tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2015.3223DOI Listing
May 2015

Endostatin has ATPase activity, which mediates its antiangiogenic and antitumor activities.

Mol Cancer Ther 2015 May 18;14(5):1192-201. Epub 2015 Mar 18.

The National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China. Beijing Key Laboratory for Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China. Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-14-0836DOI Listing
May 2015

High expression of small GTPase Rab3D promotes cancer progression and metastasis.

Oncotarget 2015 May;6(13):11125-38

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://www.oncotarget.com/fulltext/3575
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484444PMC
http://dx.doi.org/10.18632/oncotarget.3575DOI Listing
May 2015

Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody cetuximab and antibody-drug conjugates by cholesterol sequestration.

Int J Cancer 2015 Jan 14;136(1):182-94. Epub 2014 May 14.

The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Tsinghua University, Beijing, 100084, China; Beijing Key Laboratory for Protein Therapeutics, Tsinghua University, Beijing, 100084, China; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.28950DOI Listing
January 2015

Pre-clinical toxicokinetics and safety study of M2ES, a PEGylated recombinant human endostatin, in rhesus monkeys.

Regul Toxicol Pharmacol 2014 Aug 27;69(3):512-23. Epub 2014 May 27.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Beijing Key Laboratory for Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yrtph.2014.05.019DOI Listing
August 2014

PLCγ1-PKCγ signaling-mediated Hsp90α plasma membrane translocation facilitates tumor metastasis.

Traffic 2014 Aug 26;15(8):861-78. Epub 2014 Jun 26.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing, 100084, China; Beijing Key Laboratory for Protein Therapeutics, Tsinghua University, Beijing, 100084, China; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tra.12179DOI Listing
August 2014

Phase I trial of MES, a novel polyethylene glycosylated recombinant human endostatin, plus gemcitabine in advanced pancreatic cancer.

Mol Clin Oncol 2014 Jul 27;2(4):586-590. Epub 2014 Mar 27.

National Engineering Laboratory for Antitumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China ; Beijing Key Laboratory of Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China ; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, P.R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mco.2014.271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051555PMC
July 2014

MicroRNA-542-3p inhibits tumour angiogenesis by targeting angiopoietin-2.

J Pathol 2014 Apr 24;232(5):499-508. Epub 2014 Feb 24.

National Engineering Laboratory for Anti-tumour Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics and Cancer Biology Laboratory, and School of Life Sciences, Tsinghua University, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.4324DOI Listing
April 2014

Genetically engineered endostatin-lidamycin fusion proteins effectively inhibit tumor growth and metastasis.

BMC Cancer 2013 Oct 15;13:479. Epub 2013 Oct 15.

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, P, R, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-13-479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016579PMC
October 2013

Role of bone marrow-derived cells in angiogenesis: focus on macrophages and pericytes.

Cancer Microenviron 2012 Dec 20;5(3):225-36. Epub 2012 Apr 20.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing, 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12307-012-0106-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460052PMC
December 2012

The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells.

Angiogenesis 2012 Dec 19;15(4):697-711. Epub 2012 Jun 19.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10456-012-9284-yDOI Listing
December 2012

The CXCL12-CXCR4 chemokine pathway: a novel axis regulates lymphangiogenesis.

Clin Cancer Res 2012 Oct 29;18(19):5387-98. Epub 2012 Aug 29.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-12-0708DOI Listing
October 2012

Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin.

Arterioscler Thromb Vasc Biol 2012 Sep 28;32(9):e126-34. Epub 2012 Jun 28.

National Engineering Laboratory for Antitumor Protein Therapeutics; Beijing Key Laboratory for Protein Therapeutics, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/ATVBAHA.112.247502DOI Listing
September 2012

Thr90 phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery.

Biochem J 2012 Jan;441(1):387-97

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20110855DOI Listing
January 2012

Tumor-associated macrophages promote angiogenesis and melanoma growth via adrenomedullin in a paracrine and autocrine manner.

Clin Cancer Res 2011 Dec 12;17(23):7230-9. Epub 2011 Oct 12.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-11-1354DOI Listing
December 2011

Endostatin specifically targets both tumor blood vessels and lymphatic vessels.

Front Med 2011 Dec 27;5(4):336-40. Epub 2011 Dec 27.

National Engineering Laboratory for Anti-Tumor Protein Therapeutics, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11684-011-0163-5DOI Listing
December 2011

Arginine deiminase modulates endothelial tip cells via excessive synthesis of reactive oxygen species.

Biochem Soc Trans 2011 Oct;39(5):1376-81, suppl 2 p following 1382

Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST0391376DOI Listing
October 2011

Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways.

Blood 2011 Jun 11;117(23):6392-403. Epub 2011 Apr 11.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-12-322867DOI Listing
June 2011

Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse model.

Am J Pathol 2011 Mar;178(3):1298-308

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2010.11.057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070550PMC
March 2011

The regulatory mechanism of extracellular Hsp90{alpha} on matrix metalloproteinase-2 processing and tumor angiogenesis.

J Biol Chem 2010 Dec 11;285(51):40039-49. Epub 2010 Oct 11.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.181941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000986PMC
December 2010

Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells.

J Pathol 2010 Nov;222(3):249-60

National Engineering Laboratory for Anti-Tumour Protein Therapeutics, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.2760DOI Listing
November 2010

The N-terminal integrity is critical for the stability and biological functions of endostatin.

Biochemistry 2010 Aug;49(30):6420-9

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing Key Laboratory of Protein Therapeutics, and Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, P. R. China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi100489xDOI Listing
August 2010

The regulatory mechanism of Hsp90alpha secretion from endothelial cells and its role in angiogenesis during wound healing.

Biochem Biophys Res Commun 2010 Jul 15;398(1):111-7. Epub 2010 Jun 15.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2010.06.046DOI Listing
July 2010

NFAT1 mediates placental growth factor-induced myelomonocytic cell recruitment via the induction of TNF-alpha.

J Immunol 2010 Mar 22;184(5):2593-601. Epub 2010 Jan 22.

National Engineering Laboratory for Antitumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, and Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.0902378DOI Listing
March 2010

The heparin binding motif of endostatin mediates its interaction with receptor nucleolin.

Biochemistry 2009 Dec;48(49):11655-63

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing 100084, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi901265zDOI Listing
December 2009

The regulatory mechanism of Hsp90alpha secretion and its function in tumor malignancy.

Proc Natl Acad Sci U S A 2009 Dec 24;106(50):21288-93. Epub 2009 Nov 24.

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing Key Laboratory for Protein Therapeutics, Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.0908151106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795546PMC
December 2009

Pulmonary vascular destabilization in the premetastatic phase facilitates lung metastasis.

Cancer Res 2009 Oct 22;69(19):7529-37. Epub 2009 Sep 22.

Cancer Biology Laboratory and Beijing Key Laboratory of Protein Therapeutics, Department of Biological Sciences and Biotechnology and National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-08-4382DOI Listing
October 2009

Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1alpha/CXCR4 axis.

Cancer Res 2009 Aug 7;69(15):6057-64. Epub 2009 Jul 7.

Department of Biological Sciences and Biotechnology, National Engineering Laboratory for Antitumor Protein Therapeutics, Tsinghua University, Beijing, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-2007DOI Listing
August 2009

Unraveling the mysteries of endostatin.

IUBMB Life 2009 Jun;61(6):613-26

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/iub.215
Publisher Site
http://dx.doi.org/10.1002/iub.215DOI Listing
June 2009

Alpha(E)C, the C-terminal extension of fibrinogen, has chaperone-like activity.

Biochemistry 2009 May;48(18):3967-76

National Engineering Laboratory for Anti-tumor Protein Therapeutics, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi900015nDOI Listing
May 2009

Fibrinogen facilitates the anti-tumor effect of nonnative endostatin.

Biochem Biophys Res Commun 2009 Mar 22;380(2):249-53. Epub 2009 Jan 22.

Cancer Biology Laboratory, Department of Biological Sciences and Biotechnology, Tsinghua University, Qinghua Yuan 1, Beijing 100084, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2009.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676347PMC
March 2009

Fibrinogen has chaperone-like activity.

Biochem Biophys Res Commun 2009 Jan 4;378(3):662-7. Epub 2008 Dec 4.

National Engineering Laboratory for Anti-tumor Protein Therapeutics Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2008.11.112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663026PMC
January 2009

Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis.

FASEB J 2008 Aug 1;22(8):2809-20. Epub 2008 Apr 1.

Beijing Key Laboratory for Protein Therapeutics, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.08-107417
Publisher Site
http://dx.doi.org/10.1096/fj.08-107417DOI Listing
August 2008

Soluble tissue factor has unique angiogenic activities that selectively promote migration and differentiation but not proliferation of endothelial cells.

Biochem Biophys Res Commun 2008 Jun 4;370(3):489-94. Epub 2008 Apr 4.

Laboratory of Protein Chemistry, Beijing Key Laboratory for Protein Therapeutics, Department of Biological Sciences & Biotechnology, Tsinghua University, Qinghua Yuan 1, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2008.03.133DOI Listing
June 2008

Sulfate stabilizes the folding intermediate more than the native structure of endostatin.

Arch Biochem Biophys 2008 Mar 7;471(2):232-9. Epub 2008 Jan 7.

Laboratory of Protein Chemistry, Beijing Key Laboratory of Protein Therapeutics, Department of Biological Sciences & Biotechnology, Tsinghua University, Zhongguancun Street, Beijing 100084, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.abb.2007.12.011DOI Listing
March 2008

Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin.

Blood 2007 Oct 5;110(8):2899-906. Epub 2007 Jul 5.

Laboratory of Protein Chemistry, the Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2007-01-064428DOI Listing
October 2007

Contributions of Zn(II)-binding to the structural stability of endostatin.

FEBS Lett 2007 Jun 29;581(16):3027-32. Epub 2007 May 29.

Laboratory of Protein Chemistry, the Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2007.05.058DOI Listing
June 2007

Insight into the catalytic mechanism of arginine deiminase: functional studies on the crucial sites.

Proteins 2007 Feb;66(3):740-50

Protein Science Laboratory of the Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/prot.21235DOI Listing
February 2007

The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.

Blood 2006 May 10;107(9):3564-71. Epub 2006 Jan 10.

Laboratory of Protein Chemistry, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2005-07-2961DOI Listing
May 2006

Deficiency of disulfide bonds facilitating fibrillogenesis of endostatin.

J Biol Chem 2006 Jan 3;281(2):1048-57. Epub 2005 Nov 3.

Laboratory of Protein Chemistry, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M507745200DOI Listing
January 2006

Contributions of disulfide bonds in a nested pattern to the structure, stability, and biological functions of endostatin.

J Biol Chem 2005 Mar 5;280(12):11303-12. Epub 2005 Jan 5.

Laboratory of Protein Chemistry, Ministry of Education Laboratory of Protein Science, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M412072200DOI Listing
March 2005

Fibrillogenesis of apomyoglobin facilitated by aggregation sequence of yeast Sup35 in various regions.

FEBS Lett 2005 Feb;579(6):1503-8

Laboratory of Protein Chemistry, MOE Laboratory of Protein Science, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2005.01.059DOI Listing
February 2005

Low stability of nucleocapsid protein in SARS virus.

Biochemistry 2004 Aug;43(34):11103-8

Department of Biological Sciences and Biotechnology, MOE Laboratory of Protein Science, Tsinghua University, Beijing 100084, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi049194bDOI Listing
August 2004

Detection and characterization of an acid-induced folding intermediate of endostatin.

Biochem Biophys Res Commun 2004 Jul;320(3):973-8

Department of Biological Sciences and Biotechnology, MOE laboratory of Protein Science, Tsinghua University, Beijing 100084, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2004.06.047DOI Listing
July 2004

Acid-induced unfolding mechanism of recombinant human endostatin.

Biochemistry 2004 Mar;43(9):2550-7

Department of Biological Sciences and Biotechnology, MOE laboratory of Protein Science, Tsinghua University, Beijing 100084, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bi0357863DOI Listing
March 2004