Yongyong Hou

Yongyong Hou

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Yongyong Hou

Publications by authors named "Yongyong Hou"

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Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice.

Sci Total Environ 2019 Jun 2;668:310-317. Epub 2019 Mar 2.

Program of Environmental Toxicology, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.008DOI Listing
June 2019

Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic.

Toxicol Appl Pharmacol 2019 Mar 8;367:62-70. Epub 2019 Feb 8.

School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2019.02.003DOI Listing
March 2019

Triptolide enhances chemotherapeutic efficacy of antitumor drugs in non-small-cell lung cancer cells by inhibiting Nrf2-ARE activity.

Toxicol Appl Pharmacol 2018 11 6;358:1-9. Epub 2018 Sep 6.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New area, Shenyang 110122, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0041008X183040
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http://dx.doi.org/10.1016/j.taap.2018.09.004DOI Listing
November 2018

NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice.

Food Chem Toxicol 2018 Nov 21;121:495-503. Epub 2018 Sep 21.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2018.09.042DOI Listing
November 2018

Nrf2 in alcoholic liver disease.

Toxicol Appl Pharmacol 2018 10 27;357:62-69. Epub 2018 Aug 27.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2018.08.019DOI Listing
October 2018

Adipocyte-specific deficiency of Nfe2l1 disrupts plasticity of white adipose tissues and metabolic homeostasis in mice.

Biochem Biophys Res Commun 2018 09 25;503(1):264-270. Epub 2018 Jun 25.

School of Public Health, China Medical University, Shenyang, 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.06.013DOI Listing
September 2018

Impact of silencing hepatic SREBP-1 on insulin signaling.

PLoS One 2018 3;13(5):e0196704. Epub 2018 May 3.

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196704PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933792PMC
August 2018

NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes.

Oxid Med Cell Longev 2017 10;2017:7417694. Epub 2017 Sep 10.

Program of Environmental Toxicology, School of Public Health, China Medical University, Shenyang, Liaoning, China.

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https://www.hindawi.com/journals/omcl/2017/7417694/
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http://dx.doi.org/10.1155/2017/7417694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5610874PMC
July 2018

silenced insulinoma cells acquire aggressiveness and chemoresistance.

Endocr Relat Cancer 2018 03 4;25(3):185-200. Epub 2017 Dec 4.

Program of Environmental ToxicologySchool of Public Health, China Medical University, Shenyang, People's Republic of China

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http://dx.doi.org/10.1530/ERC-17-0458DOI Listing
March 2018

Silencing of long isoforms of nuclear factor erythroid 2 like 1 primes macrophages towards M1 polarization.

Free Radic Biol Med 2018 03 3;117:37-44. Epub 2018 Feb 3.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China; The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC, 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2018.01.022DOI Listing
March 2018

The impairment of glucose-stimulated insulin secretion in pancreatic β-cells caused by prolonged glucotoxicity and lipotoxicity is associated with elevated adaptive antioxidant response.

Food Chem Toxicol 2017 Feb 25;100:161-167. Epub 2016 Dec 25.

Program of Environmental Toxicology, School of Public Health, China Medical University No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, 110122, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2016.12.016DOI Listing
February 2017

An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy.

Free Radic Biol Med 2016 10 12;99:544-556. Epub 2016 Sep 12.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.09.010DOI Listing
October 2016

The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study.

Biochem Biophys Res Commun 2016 09 21;478(1):87-92. Epub 2016 Jul 21.

School of Public Health, China Medical University, Shenyang, Liaoning, PR China; The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.07.088DOI Listing
September 2016

Protective Role of Nuclear Factor E2-Related Factor 2 against Acute Oxidative Stress-Induced Pancreatic β -Cell Damage.

Oxid Med Cell Longev 2015 9;2015:639191. Epub 2015 Apr 9.

Program of Environmental Toxicology, School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, China.

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http://www.hindawi.com/journals/omcl/2015/639191/
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http://dx.doi.org/10.1155/2015/639191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407529PMC
April 2016

Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells.

Toxicol Appl Pharmacol 2016 Feb 18;292:1-7. Epub 2015 Dec 18.

School of Public Health, China Medical University, 77 Puhe Road, Shenyang North New Area, Shenyang, China; The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2015.12.008DOI Listing
February 2016

Induction of glutathione synthesis in human hepatocytes by acute and chronic arsenic exposure: differential roles of mitogen-activated protein kinases.

Toxicology 2014 Nov 6;325:96-106. Epub 2014 Sep 6.

Environmental Toxicology Program, School of Public Health, China Medical University, No. 92 North 2nd Road, Shenyang, Liaoning 110001, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.tox.2014.09.002DOI Listing
November 2014

Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes.

Toxicol Appl Pharmacol 2013 Dec 12;273(3):435-41. Epub 2013 Oct 12.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA; The First Affiliated Hospital, China Medical University, Shenyang 110001, China.

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http://dx.doi.org/10.1016/j.taap.2013.10.005DOI Listing
December 2013

Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes.

Environ Toxicol 2013 Jul 1;28(7):401-10. Epub 2011 Aug 1.

Department of Occupational and Environmental Health, Liaoning Provincial Key Laboratory of Arsenic Biological Effect and Poisoning, School of Public Health, China Medical University, Shenyang 110001, China.

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http://dx.doi.org/10.1002/tox.20731DOI Listing
July 2013

Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome.

Diabetes 2013 Mar 13;62(3):845-54. Epub 2012 Dec 13.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.2337/db12-0584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581189PMC
March 2013

Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress response.

Environ Health Perspect 2013 Feb 5;121(2):237-43. Epub 2012 Dec 5.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA.

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http://ehp.niehs.nih.gov/wp-content/uploads/121/2/ehp.120573
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http://ehp.niehs.nih.gov/2013/02/1205731/
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http://dx.doi.org/10.1289/ehp.1205731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569692PMC
February 2013

Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damage.

Toxicol Appl Pharmacol 2012 Nov 21;264(3):315-23. Epub 2012 Sep 21.

Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.taap.2012.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478490PMC
November 2012

Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.

J Proteome Res 2012 Apr 19;11(4):2480-91. Epub 2012 Mar 19.

Division of Pulmonary, Allergy and Critical Care Medicine, Small Molecule Synthesis Facility and Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, United States.

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http://dx.doi.org/10.1021/pr201180mDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327136PMC
April 2012

ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.

Toxicol Appl Pharmacol 2010 Apr 6;244(1):77-83. Epub 2009 Jun 6.

Division of Translational Biology, The Hamner Institutes for Health Sciences, 6 Davis Drive, Research Triangle Park, NC 27709, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0041008X0900224
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http://dx.doi.org/10.1016/j.taap.2009.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837798PMC
April 2010

Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophages.

Toxicol Appl Pharmacol 2009 Jul 17;238(1):27-36. Epub 2009 Apr 17.

Division of Computational Biology, The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.taap.2009.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2697450PMC
July 2009