Publications by authors named "Yongsheng Zhao"

93 Publications

Refining Inaccurate Transmitter and Receiver Positions Using Calibration Targets for Target Localization in Multi-Static Passive Radar.

Sensors (Basel) 2019 Jul 31;19(15). Epub 2019 Jul 31.

PLA Strategic Support Force Information Engineering University, Zhengzhou 86-450001, China.

Transmitter and receiver position errors have been known to significantly deteriorate target localization accuracy in a multi-static passive radar (MPR) system. This paper explores the use of calibration targets, whose positions are known to the MPR system, to counter the loss in target localization accuracy arising from transmitter/receiver position errors. This paper firstly evaluates the Cramér-Rao lower bound (CRLB) for bistatic range (BR)-based target localization with calibration targets, which analytically indicates the potential of calibration targets in enhancing localization accuracy. After that, this paper proposes a novel closed-form solution, which includes two steps: calibration step and localization step. Firstly, the calibration step is devoted to refine the inaccurate transmitter and receiver locations using the BR measurements from the calibration targets, and then in the calibration step, the target localization can be accurately achieved by using the refined transmitter/receiver positions and the BR measurements from the unknown target. Theoretical analysis and simulation results indicate that the proposed method can attain the CRLB at moderate measurement noise level, and exhibits the superiority of localization accuracy over existing algorithms.
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http://dx.doi.org/10.3390/s19153365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695934PMC
July 2019

Predicting the Toxicity of Ionic Liquids toward Acetylcholinesterase Enzymes Using Novel QSAR Models.

Int J Mol Sci 2019 May 2;20(9). Epub 2019 May 2.

School of Material and Chemical Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001, China.

Limited information on the potential toxicity of ionic liquids (ILs) becomes the bottleneck that creates a barrier in their large-scale application. In this work, two quantitative structure-activity relationships (QSAR) models were used to evaluate the toxicity of ILs toward the acetylcholinesterase enzyme using multiple linear regression (MLR) and extreme learning machine (ELM) algorithms. The structures of 57 cations and 21 anions were optimized using quantum chemistry calculations. The electrostatic potential surface area () and the screening charge density distribution area () descriptors were calculated and used for prediction of IL toxicity. Performance and predictive aptitude between MLR and ELM models were analyzed. Highest squared correlation coefficient (), and also lowest average absolute relative deviation (AARD%) and root-mean-square error (RMSE) were observed for training set, test set, and total set for the ELM model. These findings validated the superior performance of ELM over the MLR toxicity prediction model.
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http://dx.doi.org/10.3390/ijms20092186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539465PMC
May 2019

The Influence of DMDBS on Crystallization Behavior and Crystalline Morphology of Weakly-Phase-Separated Olefin Block Copolymer.

Polymers (Basel) 2019 Mar 22;11(3). Epub 2019 Mar 22.

Department of Applied Chemistry, School of Science, Analytical & Testing Center, Northwestern Polytechnical University, Xi'an 710072, China.

Olefin block copolymer (OBC), with its low hard segments, can form unique space-filling spherulites other than confined-crystallization morphologies, mainly due to its weak phase-separation. In this work, 1,3;2,4-Bis(3,4-dimethylbenzylidene) sorbitol (DMDBS), a well-known nucleating agent, was used to tailor the crystallization behavior and crystalline morphology of OBC. It was found that DMDBS can precipitate within an OBC matrix and self-assemble into crystalline fibrils when cooling from the melt. A non-isothermal crystallization process exhibited an increased crystallization rate and strong composition dependence. During the isothermal crystallization process, DMDBS showed a more obvious nucleating efficiency at a higher crystallization temperature. OBC showed typical spherulites when DMDBS was added. Moreover, a low addition of DMDBS significantly decreased the crystal size, while a large addition of DMDBS induced aggregates, due to the limited miscibility of DMDBS with OBC. The efficient nucleating effect of DMDBS on OBC led to an increased optical transparency for OBC/DMDBS composites.
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http://dx.doi.org/10.3390/polym11030552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473251PMC
March 2019

The antagonistic effect of tamoxifen against d-galactosamine/lipopolysaccharide-induced acute liver failure is associated with reactivation of hepatic nuclear factor-κB.

Immunopharmacol Immunotoxicol 2019 Apr 5;41(2):192-198. Epub 2019 Feb 5.

a The Affiliated Ganzhou Hospital of Nanchang University , Ganzhou , Jiangxi , China.

: Tamoxifen (TAM) ameliorates D-galactosamine/lipopolysaccharide (Gal/LPS)-induced acute liver failure (ALF) through its antioxidative effect; thus, this study was designed to determine whether the effectiveness of TAM is related to nuclear factor-κB (NF-κB) reactivation. : Experimental mice were injected with TAM once daily for 3 consecutive days intraperitoneally (i.p). Twelve hours after pretreatment, Gal/LPS was given to mice (i.p) for ALF induction. In the positive control group, N-acetylcysteine (NAC) was administered immediately after ALF establishment. Except for survival observation, other animals were sacrificed 7 h after Gal/LPS treatment. Survival and hepatic failure were evaluated. For the oxidation assessment, the reduced/oxidized glutathione (GSH/GSSG) ratio and hepatic superoxide dismutase (SOD) activity were analyzed using both colorimetry and Western blotting. Lastly, hepatic NF-κB activation was measured through Western blot analysis of p65 and IκBα. : The results indicated that pretreatment with TAM dramatically attenuated Gal/LPS-induced ALF, as demonstrated by improved survival (70%), decreased transaminase levels, and reversed histopathological manifestation. In addition, the hepatic GSH/GSSG ratio and SOD activity were decreased in the ALF model. However, to some degree, TAM and NAC effectively prevented this undesirable phenomenon in contrast to the ALF model. Western blotting revealed that compared with mice in the ALF model group, mice treated with TAM or NAC showed reactivation of hepatic NF-κB. : Taking the results together with those of other studies, we conclude that TAM may attenuate Gal/LPS-induced ALF by antagonizing oxidative stress through NF-κB reactivation.
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http://dx.doi.org/10.1080/08923973.2019.1569044DOI Listing
April 2019

Revealing the Unusual Rigid Boron Chain Substructure in Hard and Superconductive Tantalum Monoboride.

Chemistry 2019 Apr 8;25(19):5051-5057. Epub 2019 Mar 8.

State Key Laboratory of Superhard Materials, Jilin University, Changchun, 130012, China.

Poor electrical conductivity severely limits the diverse applications of high hardness materials in situations where electrical conductivities are highly desired. A "covalent metal" TaB with metallic electrical conductivity and high hardness has been fabricated by a high pressure and high temperature method. The bulk modulus, 302.0(4.9) GPa, and Vickers hardness, 21.3 GPa, approaches and even exceeds that of traditional insulating hard materials. Meanwhile, temperature-dependent electrical resistivity measurements show that TaB possesses metallic conductivity that rivals some widely-used conductors, and it will transform into a superconductor at T =7.8 K. Contrary to common understanding, the hardness of TaB is higher than that of TaB , which indicates that low boron concentration borides could be mechanically better than the higher boron concentration counterparts. Compression behavior and first principles calculations denote that the high hardness is associated with the ultra-rigid covalent boron chain substructure. The hardness of TaB with different topologies of boron substructure shows that besides incorporating higher boron content, manipulating light element backbone configurations is also critical for higher hardness amongst transition metal borides with identical boron content.
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http://dx.doi.org/10.1002/chem.201806043DOI Listing
April 2019

High-Load Soft Grippers Based on Bionic Winding Effect.

Soft Robot 2019 04 16;6(2):276-288. Epub 2019 Jan 16.

1 Parallel Robot and Mechatronic System Laboratory of Hebei Province, Yanshan University, Qinhuangdao, China.

The improvement of the load capacity of soft grippers has always been a challenge. To tackle this load capacity challenge, this work presents four novel types of high-load (HL) soft grippers that are bioinspired by bionic winding models. The winding models are found commonly in many animals and plants, where different winding patterns are used to grip different objects. Inspired by the winding models, we design four bionic winding structures that are driven by pneumatic artificial muscles (PAMs), and then four HL soft grippers are formed out of the winding structures. The inner cavities of the HL soft grippers contract after the PAMs are inflated, which enables objects to be wrapped to achieve gripping. Compared with most existing soft grippers, the HL soft grippers have a higher load capacity, and they can also grip various objects that have different shapes and stiffnesses without damaging them. In addition, in man-machine collaboration, operators can be in direct contact with them without being hurt. Our study helps lay the foundation for engineered systems with bionic winding structures.
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http://dx.doi.org/10.1089/soro.2018.0024DOI Listing
April 2019

Pressure-Driven Reversible Switching between n- and p-Type Conduction in Chalcopyrite CuFeS.

J Am Chem Soc 2019 Jan 6;141(1):505-510. Epub 2018 Dec 6.

Center for High Pressure Science and Technology Advanced Research (HPSTAR) , Beijing 100094 , China.

Temperature-dependent switching between p- and n-type conduction is a newly observed phenomenon in very few Ag-based semiconductors, which may promote fascinating applications in modern electronics. Pressure, as an efficient external stimulus that has driven collective phenomena such as spin-crossover and Mott transition, is also expected to initialize a conduction-type switching in transition metal-based semiconductors. Herein, we report the observation of a pressure-driven dramatic switching between p- and n-type conduction in chalcopyrite CuFeS associated with a structural phase transition. Under compression around 8 GPa, CuFeS undergoes a phase transition with symmetry breakdown from space group I-42 d to space group I-4 accompanying with a remarkable volume shrinkage of the FeS tetrahedra. A high-to-low spin-crossover of Fe ( S = 2 to S = 0) is manifested along with this phase transition. Instead of pressure-driven metallization, a surprising semiconductor-to-semiconductor transition is observed associated with the structural and electronic transformations. Significantly, both photocurrent and Hall coefficient measurements confirm that CuFeS undergoes a reversible pressure-driven p- n conduction type switching accompanying with the structural phase transition. The absence of cationic charge transfer between copper and iron during the phase transition is confirmed by both X-ray absorption near-edge spectra (Cu/Fe, K-edge) and total-fluorescence-yield X-ray absorption spectra (Fe, K-edge) results, and the valence distribution maintains CuFeS in the high-pressure phase. The observation of an abrupt pressure-driven p- n conduction type switching in a transition metal-based semiconductor paves the way to novel pressure-responsive switching devices.
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http://dx.doi.org/10.1021/jacs.8b11269DOI Listing
January 2019

Enhancing bacterial transport with saponins in saturated porous media for the bioaugmentation of groundwater: visual investigation and surface interactions.

Environ Sci Pollut Res Int 2018 Sep 10;25(26):26539-26549. Epub 2018 Jul 10.

Key Laboratory of Groundwater Resources and Environment of the Ministry of Education, College of Environment and Resources, Jilin University, 2519 Jiefang Road, Changchun, 130021, People's Republic of China.

The success of bioaugmentation processes for the remediation of groundwater contamination relies on effective transport of the injected microorganisms in a subsurface environment. Biosurfactants potentially affect bacterial attachment and transport behavior in porous media. Although saponins as biosurfactants are abundant in nature, their influence on bacterial transport in groundwater systems remains unknown. In this research, tank visual-transport experiments, breakthrough curve monitoring, and surface property measurement were performed to evaluate the effects of saponins on the transport of Pseudomonas migulae AN-1 cells, which were used as a model bacterium in saturated sand. Results show that the 0.1% saponins could effectively facilitated the AN-1 secondary transport and the addition of saponins decreased the hydrophobicity of AN-1 and sand. The role of the promotion of saponins was more dominant than that of the inhibition of ions on AN-1 transport in a saturated porous medium when ions and saponins coexisted. The interactions between AN-1 and sand grains with saponins and ions were explained in accordance with the Derjaguin-Landau-Verwey-Overbeek theory.
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http://dx.doi.org/10.1007/s11356-018-2477-1DOI Listing
September 2018

Strong Photonic-Band-Gap Effect on the Spontaneous Emission in 3D Lead Halide Perovskite Photonic Crystals.

Chemphyschem 2018 08 19;19(16):2101-2106. Epub 2018 Apr 19.

Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

Stimulated emission in perovskite-embedded polymer opal structures is investigated. A polymer opal structure is filled with a perovskite, and perovskite photonic crystals are prepared. The spontaneous emission of the perovskite embedded in the polymer opal structures exhibits clear signatures of amplified spontaneous emission (ASE) via gain modulation. The difference in refractive-index contrast between the perovskite and the polymer opal is large enough for retaining photonic-crystals properties. The photonic band gap has a strong effect on the fluorescence emission intensity and lifetime. The stimulated emission spectrum exhibits a narrow ASE rather than a wide fluorescence peak in the thin film.
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http://dx.doi.org/10.1002/cphc.201701268DOI Listing
August 2018

Using machine learning and quantum chemistry descriptors to predict the toxicity of ionic liquids.

J Hazard Mater 2018 06 15;352:17-26. Epub 2018 Mar 15.

Collaborative Innovation Center of Environmental Pollution Control and Ecological Restoration, Zhengzhou, Henan, 450001, China; Xuchang University, Xuchang, Henan, 461001, China. Electronic address:

Large-scale application of ionic liquids (ILs) hinges on the advancement of designable and eco-friendly nature. Research of the potential toxicity of ILs towards different organisms and trophic levels is insufficient. Quantitative structure-activity relationships (QSAR) model is applied to evaluate the toxicity of ILs towards the leukemia rat cell line (ICP-81). The structures of 57 cations and 21 anions were optimized by quantum chemistry. The electrostatic potential surface area (S) and charge distribution area (S) descriptors are calculated and used to predict the toxicity of ILs. The performance and predictive aptitude of extreme learning machine (ELM) model are analyzed and compared with those of multiple linear regression (MLR) and support vector machine (SVM) models. The highest R and the lowest AARD% and RMSE of the training set, test set and total set for the ELM are observed, which validates the superior performance of the ELM than that of obtained by the MLR and SVM. The applicability domain of the model is assessed by the Williams plot.
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http://dx.doi.org/10.1016/j.jhazmat.2018.03.025DOI Listing
June 2018

Assessment of future climate change impacts on nonpoint source pollution in snowmelt period for a cold area using SWAT.

Sci Rep 2018 02 5;8(1):2402. Epub 2018 Feb 5.

Key Lab of Groundwater Resources and Environment, College of the Environment and Resources, Jilin University, Changchun, Jilin Province, 130021, China.

The source area of Liao River is a typical cold region in northeastern China, which experiences serious problems with agricultural nonpoint source pollution (NPS), it is important to understand future climate change impacts on NPS in the watershed. This issue has been investigated by coupling semi distributed hydrological model (SWAT), statistical downscaling model (SDSM) and global circulation model (GCMs). The results show that annual average temperature would rise by 2.1 °C (1.3 °C) in the 2080 s under scenario RCP8.5 (RCP4.5), and annual precipitation would increase by 67 mm (33 mm). The change in winter temperature and precipitation is most significant with an increase by 0.23 °C/10a (0.17 °C/10a) and 1.94 mm/10a (2.78 mm/10a). The future streamflow, TN and TP loads would decrease by 19.05% (10.59%), 12.27% (8.81%) and 10.63% (6.11%), respectively. Monthly average streamflow, TN and TP loads would decrease from March to November, and increase from December to February. This is because the increased precipitation and temperature in winter, which made the spring snowpack melting earlier. These study indicate the trends of nonpoint source pollution during the snowmelt period under climate change conditions, accordingly adaptation measures will be necessary.
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http://dx.doi.org/10.1038/s41598-018-20818-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799487PMC
February 2018

The revision of 8th edition TNM stage criteria is more accurate in prediction postoperative survival for SCLC patients.

Int J Surg 2017 Dec 5;48:83-85. Epub 2017 Oct 5.

Department of Thoracic Surgery, West China Hospital of Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan 610041, China. Electronic address:

Objectives: The 8th edition TNM lung cancer classification was enacted in January 2017. An important change is the old T2a was revised to new T2a and T2b. Whether a postoperative survival difference exists between the two stages is still undefined. The purpose of this study is to investigate the postoperative outcomes of small cell lung cancer (SCLC) patients and compare the survival difference between the two stages.

Methods: Data of patients with SCLC who underwent surgery between October 2005 and August 2013 at our institute were reviewed. A total number of 194 patients were enrolled and were reclassified according to the 8th edition TNM stage. Survival was determined by Kaplan-Meier analysis, the log-rank test was used to compare survival differences.

Results: Surgical resection included 165 lobectomy or bilobectomy, 19 sublobectomy and 10 pneumonectomy. There were 159 patients received chemotherapy, 35 underwent surgery alone. The 5-year survival rate and median survival time (MST) of whole group was 34.5% and 45 months. For patients who received similar therapy (surgery plus chemotherapy) in N0 stage, the MST of T2a stage was 83 months, significantly longer than 62 months in T2b stage (P = 0.017).

Conclusions: In the 8th edition TNM lung cancer stage criteria, the postoperative survival of T2a is superior to T2b for non-metastatic SCLC at N0 stage.
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http://dx.doi.org/10.1016/j.ijsu.2017.09.072DOI Listing
December 2017

A mechanism study of airflow rate distribution within the zone of influence during air sparging remediation.

Sci Total Environ 2017 Dec 25;609:377-384. Epub 2017 Jul 25.

Key Laboratory of Groundwater Resources and Environment, Ministry of Education, Jilin University, Changchun 130021, China.

In this study, an improved laboratory two-dimensional airflow visualization device was developed for the quantitative analysis of airflow distribution at different heights from the sparger (20, 30, and 40cm) within the zone of influence (ZOI). The results indicated that the measured airflow rate distribution appeared Trapezium when the height was 20cm; however, the airflow rate matched a Gaussian distribution when the heights became 30cm and 40cm. The conical shape of the ZOI was observed in the experimental processes. The experimental results verified that the airflow distribution within the ZOI conformed to turbulent jet theory. According to turbulent jet theory, the distribution of the airflow rate changes from Trapezium to Gaussian, and the jet boundary mixed layer is a linear extension in the processes of jets. Through our study, it was found that this theory could be applied to airflow distribution and predictive models for the ZOI in air sparging remediation. The shape of the ZOI should be cone-like and the boundary layer of the ZOI is a linear extension in air sparging process. All the results from this study can provide theoretical support for the design and prediction of air sparging remediation for groundwater pollution.
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http://dx.doi.org/10.1016/j.scitotenv.2017.07.169DOI Listing
December 2017

Database and new models based on a group contribution method to predict the refractive index of ionic liquids.

Phys Chem Chem Phys 2017 Aug;19(30):19967-19974

Beijing Key Laboratory of Ionic Liquids Clean Process, Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Refractive index is one of the important physical properties, which is widely used in separation and purification. In this study, the refractive index data of ILs were collected to establish a comprehensive database, which included about 2138 pieces of data from 1996 to 2014. The Group Contribution-Artificial Neural Network (GC-ANN) model and Group Contribution (GC) method were employed to predict the refractive index of ILs at different temperatures from 283.15 K to 368.15 K. Average absolute relative deviations (AARD) of the GC-ANN model and the GC method were 0.179% and 0.628%, respectively. The results showed that a GC-ANN model provided an effective way to estimate the refractive index of ILs, whereas the GC method was simple and extensive. In summary, both of the models were accurate and efficient approaches for estimating refractive indices of ILs.
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http://dx.doi.org/10.1039/c7cp03214eDOI Listing
August 2017

Abnormal Pressure-Induced Photoluminescence Enhancement and Phase Decomposition in Pyrochlore La Sn O.

Adv Mater 2017 Sep 10;29(34). Epub 2017 Jul 10.

Center for High Pressure Science and Technology Advanced Research (HPSTAR), Shanghai, 201203, China.

La Sn O is a transparent conducting oxide (TCO) material and shows a strong near-infrared fluorescent at ambient pressure and room temperature. By in situ high-pressure research, pressure-induced visible photoluminescence (PL) above 2 GPa near 2 eV is observed. The emergence of unusual visible PL behavior is associated with the seriously trigonal lattice distortion of the SnO octehedra, under which the Sn-O1-Sn exchange angle θ is decreased below 22.1 GPa, thus enhancing the PL quantum yield leading to Sn P → S photons transition. Besides, bandgap closing followed by bandgap opening and the visible PL appearing at the point of the gap reversal, which is consistent with high-pressure phase decomposition, are discovered. The high-pressure PL results demonstrate a well-defined pressure window (7-17 GPa) with flat maximum PL yielding and sharp edges at both ends, which may provide a great calibration tool for pressure sensors for operation in the deep sea or at extreme conditions.
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http://dx.doi.org/10.1002/adma.201701513DOI Listing
September 2017

Visualisation study on Pseudomonas migulae AN-1 transport in saturated porous media.

Water Res 2017 10 7;122:329-336. Epub 2017 Jun 7.

Key Laboratory of Groundwater Resources and Environment of the Ministry of Education, College of Environment and Resources, Jilin University, 2519 Jiefang Road, Changchun, 130021, PR China. Electronic address:

Influence of granular size and groundwater flow rate on transport of Pseudomonas migulae AN-1 in saturated porous media was non-invasively and visually investigated with a novel imaging technique based on our previously established green fluorescent protein-tagging approach. AN-1 was transported faster than water was. The finer the media were, the greater the enhancement of bacterial velocity was. Mass recovery (MR) increased, while deposition rate coefficient (K) decreased, with increasing granular size. Similar and linear trends of MR and K, respectively, were quantitatively observed with increasing water flow rate. The images revealed that the initial shape of bacterial plume after injection was a narrow strip along the injection well and an ellipsoid in the lower part of the injection well in medium and coarse sand, respectively. Bacterial plume migrated horizontally in medium sand, but shifted slightly downward in coarse sand. Under similar conditions, the fluorescent area carrying AN-1 in medium sand was larger than that carrying AN-1 in coarse sand during the same period. The visualisation method of this study captured both the movement of free-state and retained bacteria that adhered to sediments. A continuous biological zone composed of planktonic and retained AN-1 was observed. These findings are significant for actual bioremediation.
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http://dx.doi.org/10.1016/j.watres.2017.06.012DOI Listing
October 2017

Prognostic factors for overall survival after lung metastasectomy in renal cell cancer patients: A systematic review and meta-analysis.

Int J Surg 2017 May 27;41:70-77. Epub 2017 Mar 27.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Guoxuexiang, No. 37, Chengdu, 610041, Sichuan, China. Electronic address:

Background: Pulmonary metastasis of Renal cell carcinomas (RCC) is usually considered as a systemic disease. However, some studies revealed potential survival benefits of pulmonary metastasectomies for such patients. The aim of this study was to conduct a systematic review and meta-analysis to assess the prognostic factors for pulmonary metastasectomy of RCC patients.

Methods: An electronic search in MEDLINE, EMBASE, CENTRAL and Chinese BioMedical Literature Database (CBM) were conducted to identify eligible studies. We combined the hazard ratios (HRs) of the identified prognostic factors for overall survival of RCC patients after pulmonary metastasectomy from the eligible studies.

Results: Sixteen studies with a total of 1447 patients were included in this meta-analysis. The pooled 1, 3, 5, 10-year overall survival rates for RCC patient after pulmonary metastasectomy were 84%, 59%, 43% and 20%, respectively. The poor prognostic factors were lymph node involvement (LNI) of primary RCC (HR 3.44, 95% confidence interval (CI) 1.78-6.67, P = 0.001), incomplete resection of metastases (HR 3.74, 95% CI 2.49-5.61, P = 0.000), multiple metastases (HR 1.55, 95% CI 1.18-2.03, P = 0.002), larger metastases (HR 1.45, 95% CI 1.26-1.66, P = 0.000), LNI of metastases (HR 3.06, 95% CI 1.52-6.19, P = 0.002), synchronous metastasis (HR 2.49, 95% CI 1.46-4.24, P = 0.001) and short disease free interval (DFI).

Conclusions: Surgery may be a promising treatment for pulmonary metastases of RCC patients. A short DFI, LNI of primary RCC, incomplete resection of metastases, multiple metastases, larger metastases, LNI of metastases and synchronous metastasis are predictors of poor survival after pulmonary metastasectomy for RCC patients.
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http://dx.doi.org/10.1016/j.ijsu.2017.03.062DOI Listing
May 2017

Loss of phosphatase and tensin homolog expression correlates with clinicopathological features of non-small cell lung cancer patients and its impact on survival: A systematic review and meta-analysis.

Thorac Cancer 2017 05 6;8(3):203-213. Epub 2017 Mar 6.

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.

Background: Phosphatase and tensin homolog ( PTEN ), regarded as a tumor suppressor gene, may act as a prognostic biomarker in human cancers.

Methods: All eligible studies from MEDLINE, Embase, CENTRAL, and the Chinese BioMedical Literature Database to October 2016 were incorporated. Two reviewers independently screened the literature according to inclusion and exclusion criteria, extracted the data, assessed the methodological quality of the included studies, and conducted meta-analysis.

Results: A total of 2486 patients from 19 studies were included. PTEN expression was significantly correlated with gender, smoking history, histology (adenocarcinoma [ADC] vs. squamous cell carcinoma), tumor node metastasis stage (I-II vs. III-IV), N status (N0 vs. N1-N3), and distant metastasis (M0 vs. M1). Loss of PTEN expression was associated with poorer overall survival, but had no significant association with disease-free survival. Subgroup analysis showed that negative PTEN expression was associated with a poorer outcome in Asian and ADC patients, but not in Western or squamous cell carcinoma patients.

Conclusion: Loss of PTEN might play an unfavorable prognostic role for overall survival of non-small cell lung cancer patients, especially Asian or ADC patients.
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http://dx.doi.org/10.1111/1759-7714.12425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415467PMC
May 2017

A Single Crystal with Multiple Functions of Optical Waveguide, Aggregation-Induced Emission, and Mechanochromism.

ACS Appl Mater Interfaces 2017 Mar 1;9(10):8910-8918. Epub 2017 Mar 1.

Beijing National Laboratory for Molecular Sciences and Key Laboratory of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.

A novel single crystal, PyB, is produced in a high yield by the simple method of connecting a pyrene unit and a rhodamine B moiety together. PyB shows multiple functions of aggregation-induced emission, low-loss optical waveguiding, and tricolored mechanochromism. The crucial point for fabricating such a multifunctional single crystal is selecting the C═N group as a spacer, which simplifies the synthetic procedure, confines the molecular conformation to develop single crystals, and allows one to dynamically observe the color variation in situ and quantitatively analyze the effect of applied pressures. Such a simple approach may be extended to other fluorophores, thus providing a new opportunity for the real world application of mechanochromic materials for mechanical sensors, optical encoding, and optoelectronic devices, etc.
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http://dx.doi.org/10.1021/acsami.7b00195DOI Listing
March 2017

A Comparative Study of Video-Assisted Thoracic Surgery with Thoracotomy for Middle Lobe Syndrome.

World J Surg 2017 Mar;41(3):780-784

Department of Thoracic Surgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, Sichuan, 610041, China.

Objectives: The aim of this study is to evaluate the feasibility and safety of video-assisted thoracic surgery (VATS) for the treatment of middle lobe syndrome (MLS) through comparison with thoracotomy during the same period.

Methods: We retrospectively reviewed all consecutive patients with MLS who underwent lobectomy or lingular segmentectomy between December 2005 and November 2015 in a single institute. Thirty patients were enrolled and divided into two groups: VATS group (n = 19) and thoracotomy group (n = 11). Data regarding the patients' demographics, medical history were collected and statistically compared.

Results: All patients received successful middle lobe resection or lingular segmentectomy. In terms of operation time, blood transfusion, chest drainage amount, duration of chest drainage and postoperative complications, no significant differences were found between the two groups (p > 0.05). The mean intraoperative blood loss of VATS group was less than thoracotomy group (79.0 ± 63.9 vs. 165 ± 94.9 ml, p = 0.04). In VATS group, the mean length of postoperative hospital stay was 6.0 ± 2.4 days, shorter than that in group thoracotomy (9.0 ± 3.5 days, p = 0.01).

Conclusions: VATS was a feasible and safe method for the surgical treatment of MLS in selected patients when no severe calcified lymph nodes surrounding hilus pulmonis was observed by preoperative chest CT scan.
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http://dx.doi.org/10.1007/s00268-016-3777-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313576PMC
March 2017

Tuning the Solid State Emission of the Carbazole and Cyano-Substituted Tetraphenylethylene by Co-Crystallization with Solvents.

Small 2016 Dec 20;12(47):6554-6561. Epub 2016 Jul 20.

Beijing National Laboratory for Molecular Sciences, Laboratories of Organic Solids and Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.

Solid state emissive materials with high quantum yields and tunable emissions are desirable for various applications. A new TPE derivative (1) with two carbazole moieties and two cyano groups is reported, which shows typical aggregation induced emission behavior. Four crystals 1a, 1b, 1c, and 1d are obtained after crystallization from N,N-dimethylformamid (DMF), trichloromethane (CHCl ), tetrahydrofuran (THF), and dichloromethane (CH Cl ), respectively. Crystal structural analyses reveal that (i) molecules of 1 co-crystallize with DMF, CHCl , THF, and CH Cl in 1a, 1b, 1c, and 1d, respectively, and (ii) conformations of 1 are different within 1a, 1b, 1c, and 1d, and compound 1 within crystal 1a adopts the most twisting conformation. Crystalline solids 1a, 1b, 1c, and 1d exhibit high emission quantum yields up to 0.65, but their emission colors are varied from blue to green. In comparison, the amorphous solid of 1 is yellow-emissive with emission maximum at 542 nm. Moreover, the blue- or green-emissive crystalline solids and the yellow-emissive amorphous solid can be inter-converted by the grinding of crystalline solids and exposure of the amorphous solid to vapors of appropriate solvents. It is also demonstrated that microrods of 1a, 1b, and 1d show typical optical waveguiding behavior.
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http://dx.doi.org/10.1002/smll.201601516DOI Listing
December 2016

Efficacy of forming biofilms by Pseudomonas migulae AN-1 toward in situ bioremediation of aniline-contaminated aquifer by groundwater circulation wells.

Environ Sci Pollut Res Int 2016 Jun 26;23(12):11568-73. Epub 2016 Apr 26.

Key Laboratory of Groundwater Resources and Environment of the Ministry of Education, College of Environment and Resources, Jilin University, 2519 Jiefang Road, Changchun, 130021, People's Republic of China.

The formation and activity of aniline-degrading biofilms developed by the psychrotrophic Pseudomonas migulae AN-1 were studied for the in situ remediation of contaminated aquifer using in-well bioreactor of groundwater circulating wells (GCWs). Biofilms grown in mineral salt medium with aniline exhibited tolerance to high concentrations of aniline. In aniline degradation rate, AN-1 biofilms exhibited slight differences compared with planktonic cells. The effectiveness and bio-implication of AN-1 biofilms in GCWs were investigated to treat aniline-contaminated aquifer. The results demonstrate that AN-1 biofilms survived the GCWs treatment process with high aniline-degrading efficiency. This system provides a novel environmentally friendly technology for the in situ bioremediation of low-volatile contaminants.
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http://dx.doi.org/10.1007/s11356-016-6737-7DOI Listing
June 2016

Bioaugmentation with GFP-Tagged Pseudomonas migulae AN-1 in Aniline-Contaminated Aquifer Microcosms: Cellular Responses, Survival and Effect on Indigenous Bacterial Community.

J Microbiol Biotechnol 2016 May;26(5):891-9

Key Laboratory of Groundwater Resources and Environment of the Ministry of Education, College of Environment and Resources, Jilin University, Changchun 130021, P.R. China.

The recently isolated aniline-degrading bacterium Pseudomonas migulae AN-1 was tagged with green fluorescent protein (GFP) to investigate its bioaugmentation potential against anilinecontaminated groundwater through microcosm experiments. The survival and cellular response of GFP-tagged AN-1 introduced in a lab-scale aquifer corresponded directly with aniline consumption. During the process, the GFP-tagged AN-1 biomass increased from 7.52 × 10⁵ cells/ml to 128 × 10⁵ cells/ml and the degradation rate of aniline was 6.04 mg/l/h. GFP-tagged AN-1 was moderately hydrophobic (41.74%-47.69%) when treated with 20- 100 mg/l aniline and exhibited relatively strong hydrophobicity (55.25%-65.78%) when the concentration of aniline was ≥100 mg/l. The membrane permeability of AN-1 increased followed by a rise in aniline below 100 mg/l and was invariable with aniline above 100 mg/l. Pyrosequencing analysis showed that the relative abundance of Proteobacteria (accounted for 99.22% in the non-bioaugmentation samples) changed to 89.23% after bioaugmentation with GFP-tagged AN-1. Actinobacteria increased from 0.29% to 2.01%, whereas the abundance of Firmicutes barely changed. These combined findings demonstrate the feasibility of removing aniline in aquifers by introducing the strain AN-1 and provide valuable information on the changes in the diversity of dominant populations during bioaugmentation.
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http://dx.doi.org/10.4014/jmb.1511.11070DOI Listing
May 2016

Effect of stretching on the mechanical properties in melt-spun poly(butylene succinate)/microfibrillated cellulose (MFC) nanocomposites.

Carbohydr Polym 2016 Apr 24;140:383-92. Epub 2015 Dec 24.

Department of Polymer Science and Materials, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, People's Republic of China. Electronic address:

In order to prepare poly(butylene succinate)/microfibrillated cellulose composites with high performance, in this work, microfibrillated cellulose (MFC) was first treated by acetylchloride with ball-milling to improve its interfacial compatibility with poly(butylene succinate) (PBS). Then melt stretching processing was adopted to further improve the dispersion and orientation of MFC in as-spun PBS fiber. And the effect of MFC on the crystalline structure and mechanical properties were systematically investigated for the melt-spun fibers prepared with two different draw ratios. The dispersion, alignment of the MFC and interfacial crystalline structure in the composite fibers are significantly influenced by the stretching force during the melt spinning. The possible formation of nanohybrid shish kebab (NHSK) superstructure where aligned MFC as shish and PBS lamellae as kebab has been suggested via SEM and SAXS in the composite fibers prepared at the high draw ratio. Large improvement in tensile strength has been realized at the high draw ratio due to the enhanced orientation and dispersion of MFC as well as the formation of NHSK.
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http://dx.doi.org/10.1016/j.carbpol.2015.12.040DOI Listing
April 2016

Hybrid Top-Down/Bottom-Up Strategy Using Superwettability for the Fabrication of Patterned Colloidal Assembly.

ACS Appl Mater Interfaces 2016 Feb 12;8(7):4985-93. Epub 2016 Feb 12.

The Laboratory of Bio-Inspired Smart Interface Sciences, Technical Institute of Physics and Chemistry, Chinese Academy of Science , Beijing 100190, China.

Superwettability of substrates has had a profound influence on the production of novel and advanced colloidal assemblies in recent decades owing to its effect on the spreading area, evaporation rate, and the resultant assembly structure. In this paper, we investigated in detail the influence of the superwettability of a transfer/template substrate on the colloidal assembly from a hybrid top-down/bottom-up strategy. By taking advantage of a superhydrophilic flat transfer substrate and a superhydrophobic groove-structured silicon template, the patterned colloidal microsphere assembly was formed including linear and mesh-, cyclic-, and multistopband assembly arrays of microspheres, and the optic-waveguide of a circular colloidal structure was demonstrated. We believed this liquid top-down/bottom-up strategy would open an efficient avenue for assembling/integrating microspheres building blocks into device applications in a low-cost manner.
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http://dx.doi.org/10.1021/acsami.5b11945DOI Listing
February 2016

A flavone-based turn-on fluorescent probe for intracellular cysteine/homocysteine sensing with high selectivity.

Talanta 2016 14;146:41-8. Epub 2015 Aug 14.

School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences (UCAS), Beijing 100049, PR China. Electronic address:

A new type of flavone-based fluorescent probe (DMAF) capable of cysteine (Cys)/homocysteine (Hcy) sensing with high selectivity over other amino acids was developed. Such type of probe undergoes Cys/Hcy-mediated cyclization reaction with the involvement of its aldehyde group, which suppresses of the photoinduced electron transfer (PET) process of the probe molecule and consequently leads to the enhancement of fluorescence emission upon excitation using visible light. The formation of product of the Cys/Hcy-mediated cyclization reaction was confirmed and the preliminary fluorescence imaging experiments revealed the biocompatibility of the as-prepared probe and validated its practicability for intracellular Cys/Hcy sensing.
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http://dx.doi.org/10.1016/j.talanta.2015.08.025DOI Listing
September 2016

[Long term outcomes of patients with stage I lung cancer treated by single-direction video-assisted thoracoscopic surgery lobectomy or segmentectomy].

Zhonghua Wai Ke Za Zhi 2015 Oct;53(10):742-6

Department of Thoracic Surgery, West China Hospital, Sichuan University, Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Chengdu 610041, China; Email:

Objective: To observe the outcome of stage I lung cancer treated by single-direction video-assisted thoracoscopic surgery (SD-VATS) major lung resection.

Methods: Between May 2006 and December 2013, a total of 3 743 patients with lung cancer underwent surgical treatment in Department of Thoracic Surgery, West China Hospital. The clinical date of 783 patients with stage I lung cancer treated by SD-VATS lobectomy/segmentectomy was analyzed retrospectively. There were 388 males and 395 females with a mean age of (59 ± 10) years (range 25 to 86 years). There were 740 cases of lobectomy and 43 cases of segmentectomy. Twenty patients underwent conversion to open thoracotomy. The methods of Kaplan-Meier survival analysis and Cox proportional hazard regression model were used to investigate the long term outcome and prognostic factors.

Results: The mean operating time was (145 ± 54) minutes (range 70 to 460 minutes). The median intraoperative blood loss was 50 (70) ml (range 5 to 1 200 ml). The postoperative morbidity and 90-day mortality were 13.3% and 1.0%, respectively. 5.9% patients were lost to follow-up. Finally 730 patients were enrolled into prognostic analysis with a mean follow-up time of (37 ± 18) months (range 5 to 92 months). The 5-year overall survival (OS), disease free survival (DFS), and cancer specific survival (CSS) were 83.8%, 74.4%, and 86.6%, respectively. The 5-year OS of IA and IB were 90.7% and 79.8% respectively. Univariate and multivariate analysis indicated that age ≥ 60 years (OR = 1.786, 95% CI: 1.081 to 2.948, P = 0.023), non-adenocarcinoma (OR = 1.647, 95% CI: 1.204 to 2.253, P = 0.002), and higher T status (OR = 2.709, 95% CI: 1.031 to 7.121, P = 0.043) were independently associated with poor OS; higher T status (OR = 5.118, 95% CI: 2.330 to 11.240, P = 0.000) and higher pathological stage status (OR = 0.369, 95% CI: 0.137 to 0.991, P = 0.048) were independently associated with poor DFS; non-adenocarcinoma (OR = 1.717, 95% CI: 1.224 to 2.409, P = 0.002) and higher T status (OR = 5.029, 95% CI: 1.432 to 17.659, P = 0.012) were independently associated with poor CSS.

Conclusion: SD-VATS lung cancer resection is a safe and feasible method for the treatment of stage I lung cancer resulting good outcomes.
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October 2015

Simultaneous thoracoscopic resection for coexisting pulmonary and thymic lesions.

J Thorac Dis 2015 Sep;7(9):1637-42

Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

Background: The management of synchronous thymic and pulmonary lesions remains a challenge due to the lack of case series and surgical guidelines. This study aims to retrospectively review our preliminary experience and results of performing simultaneous thoracoscopic resection of coexisting diseases of the lung and thymus.

Methods: Simultaneous thoracoscopic resection was performed to remove coexisting thymic and pulmonary lesions in nine patients from August 2008 to November 2013. Patient demographics, preoperative assessment, surgical procedures and postoperative course of these patients were reviewed.

Results: There were four female and five male patients between 43 and 70 years old (median age, 64 years). Each patient had thymic neoplasm and solitary pulmonary lesion on chest computed tomography (CT) scan. Four patients underwent thoracoscopic lobectomy and thymectomy. One patient had thoracoscopic bronchovascular sleeve lobectomy combined with thymic cyst resection (TCR). The other four patients received pulmonary wedge resection and thymectomy (n=3)/TCR (n=1). The operation lasted from 35-480 min (median, 110 min). Intra-operative blood loss was 20-380 mL (median, 120 mL). Two patients developed post-operative pneumonia without mortality. All the patients were discharged home within 9 days after surgery. Two patients died from metastatic lung cancer 14 months after surgery.

Conclusions: Simultaneous thoracoscopic resection of coexisting pulmonary and thymic lesions is safe and feasible in selected patients.
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http://dx.doi.org/10.3978/j.issn.2072-1439.2015.09.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598524PMC
September 2015

A Luminescent Nitrogen-Containing Polycyclic Aromatic Hydrocarbon Synthesized by Photocyclodehydrogenation with Unprecedented Regioselectivity.

Chemistry 2015 Dec 22;21(49):17973-80. Epub 2015 Oct 22.

HKUST-Shenzhen Research Institute, No. 9 Yuexing 1st RD, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057 (P.R. China).

We present a nitrogen-containing polycyclic aromatic hydrocarbon (N-PAH), namely 12-methoxy-9-(4-methoxyphenyl)-5,8-diphenyl-4-(pyridin-4-yl)pyreno[1,10,9-h,i,j]isoquinoline (c-TPE-ON), which exhibits high quantum-yield emission both in solution (blue) and in the solid state (yellow). This molecule was unexpectedly obtained by a three-fold, highly regioselective photocyclodehydrogenation of a tetraphenylethylene-derived AIEgen. Based on manifold approaches involving UV/Vis, photoluminescence, and NMR spectroscopy as well as HRMS, we propose a reasonable mechanism for the formation of the disk-like N-PAH that is supported by density functional theory calculations. In contrast to most PAHs that are commonly used, our system does not suffer from entire fluorescence quenching in the solid state due to the peripheral aromatic rings preventing π-π stacking interactions, as evidenced by single-crystal X-ray analysis. Moreover, its rod-like microcrystals exhibit excellent optical waveguide properties. Hence, c-TPE-ON comprises a N-PAH with unprecedented luminescent properties and as such is a promising candidate for fabricating organic optoelectronic devices. Our design and synthetic strategy might lead to a more general approach to the preparation of solution- and solid-state luminescent PAHs.
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http://dx.doi.org/10.1002/chem.201503147DOI Listing
December 2015

Improved light-transmission method for the study of LNAPL migration and distribution rule.

Water Sci Technol 2015 ;71(10):1576-85

Key Laboratory of Groundwater Resources and Environment, Ministry of Education, Jilin University, Changchun 130021, China E-mail:

In this study, diesel was selected as a pollutant to study the migration and distribution rule of light non-aqueous phase liquid (LNAPL) in the simulated vadose zone. Saturation was regarded as a critical parameter to reflect the LNAPL migration and distribution rule. To get LNAPL saturation distribution figures, an image processing method of saturation was established to improve light-transmission technology, which can deal with digital camera images. Results showed that the vadose zone contains three areas from top to bottom, named dry media, transition zone and capillary zone. The system has two interfaces at which moisture content increased significantly. The significant increase in moisture content induced two apparent horizontal LNAPL diffusions in the two interfaces. Furthermore, the highly saturated LNAPL was mostly distributed near the wet interface, which lay between the dry media and the transition zone. Moreover, the downstream expansion of LNAPL in the capillary zone was promoted by groundwater flow, yet cutting off LNAPL supply could stop the downstream expansion after a period of time. The accuracy of this image processing method of saturation was verified by mass balance theory and reported a relative error of 4.38%.
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http://dx.doi.org/10.2166/wst.2015.141DOI Listing
December 2015
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