Publications by authors named "Yongqiang Ji"

21 Publications

  • Page 1 of 1

Tuning optical properties of CsPbBr3 by mixing Nd3+trivalent lanthanide halide cations for blue light emitting devices.

Nanotechnology 2022 Jan 13. Epub 2022 Jan 13.

Department of Physics, COMSATS Institute of Information Technology, Center for Micro and Nano Devices, Park Road, Islamabad, 44000, PAKISTAN.

In recent years, significant progress has been made in the red and green perovskite quantum dots (PQDs) based light-emitting devices. However, a scarcity of blue-emitting devices that are extremely efficient precludes their research and development for optoelectronic applications. Taking advantage of tunable bandgaps of PQDs over the entire visible spectrum, herein we tune optical properties of CSPbBr3 by mixing Nd3+ trivalent lanthanide halide cations for blue light-emitting devices. The CsPbBr3 PQDs doped with Nd3+ trivalent lanthanide halide cations emitted strong photoemission from green into the blue region. By adjusting their doping concentration, a tunable wavelength from (515 nm) to (450 nm) was achieved with FWHM from (37.83 nm) to (16.6 nm). We simultaneously observed PL linewidth broadening thermal quenching of PL and the blue shift of the optical bandgap from temperature-dependent PL studies. The Nd3+ cations into CsPbBr3 PQDs more efficiently reduced non-radiative recombination. As a result of the efficient removal of defects from PQDs, the photoluminescence quantum yield (PLQY) has been significantly increased to 91% in the blue-emitting region. Significantly, Nd3+ PQDs exhibit excellent long-term stability against the external environment, including water, temperature, and ultraviolet light irradiation. Moreover, we successfully transformed Nd3+ doped PQDs into highly fluorescent nanocomposites. Incorporating these findings, we fabricate and test a stable blue light-emitting LED with EL emission at (462 nm), (475 nm), and successfully produce white light emission from Nd3+ doped nanocomposites with a CIE at (0.32, 0.34), respectively. The findings imply that low-cost Nd3+ doped perovskites may be attractive as light converters in LCDs with a broad color gamut.
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http://dx.doi.org/10.1088/1361-6528/ac4b2eDOI Listing
January 2022

Comparison of Levitt's CO breath test and the N-glycine labeling technique for measuring the lifespan of human red blood cells.

Am J Hematol 2021 10 4;96(10):1232-1240. Epub 2021 Aug 4.

Anemia Therapeutic Centre, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.

The red blood cell (RBC) lifespan is an important physiological indicator of clear significance in clinical research, used for the differential diagnosis of various diseases such as anemia, compensatory phase hemolysis, and polycythemia. The N-glycine labeling technique is the gold standard method for determining RBC lifespans. However, the usefulness of this technique in clinical settings is seriously hindered by the several weeks required to complete the analyses. Levitt's CO breath test is another reliable technique for determining RBC lifespans, with a simpler protocol giving much faster results, making it more useful in clinical applications. We compared the CO breath test and N-glycine labeling technique for measuring the human RBC lifespan. We investigated human RBC lifespans where each subject undertook both the N-glycine labeling technique and the CO breath test. The correlation between the results from these two methods was analyzed. Eight of the ten subjects successfully completed the study. The RBC lifespan values obtained by Levitt's CO breath test were lower than those obtained by the N-glycine labeling technique. The RBC lifespan values determined from the N-glycine labeling technique and the CO breath test were significantly correlated, with a Pearson correlation coefficient of R = 0.98 (p < 0.05), while the R of the linear regression equation was 0.96. The CO breath test exhibits as good performance as the N-glycine labelling technique in distinguishing healthy subjects from subjects with hemolysis. The result suggests that the CO breath test is a reliable method for quickly determining human RBC lifespans in clinical applications.
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http://dx.doi.org/10.1002/ajh.26290DOI Listing
October 2021

Trioctylphosphine-Assisted Pre-protection Low-Temperature Solvothermal Synthesis of Highly Stable CsPbBr/TiO Nanocomposites.

J Phys Chem Lett 2021 Apr 13;12(15):3786-3794. Epub 2021 Apr 13.

Centre for Micro and Nano Devices, Department of Physics, COMSATS Institute of Information Technology, Islamabad 44500, Pakistan.

Lead halide perovskite quantum dots (PQDs) are reported as a promising branch of perovskites, which have recently emerged as a field in luminescent materials research. However, before the practical applications of PQDs can be realized, the problem of poor stability has not yet been solved. Herein, we propose a trioctylphosphine (TOP)-assisted pre-protection low-temperature solvothermal synthesis of highly stable CsPbBr/TiO nanocomposites. Due to the protection of branched ligands and the lower temperature of shell formation, these TOP-modified CsPbBr PQDs are successfully incorporated into a TiO monolith without a loss of fluorescence intensity. Because the excellent nature of both parent materials is preserved in CsPbBr/TiO nanocomposites, it is found that the as-prepared CsPbBr/TiO nanocomposites not only display excellent photocatalytic activity but also yield improved PL stability, enabling us to build highly stable white light-emitting diodes and to photodegrade rhodamine B.
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http://dx.doi.org/10.1021/acs.jpclett.1c00693DOI Listing
April 2021

A versatile approach for shape-controlled synthesis of ultrathin perovskite nanostructures.

Dalton Trans 2021 Mar;50(9):3308-3314

Centre for Micro and Nano Devices, Department of Physics, COMSATS Institute of Information Technology, Islamabad, 44500, Pakistan.

Very recently, ultrathin perovskite nanostructures, with the advantages of perovskite and ultrathin properties, have received an enormous level of interest due to their many fascinating properties, such as a strong quantum confinement effect and a large specific surface area. In spite of this incredible success of perovskite nanocrystals (NCs), the development of perovskite NCs is still in its infancy, and the production of high-quality ultrathin perovskite nanostructures has been a hot topic in the fields of nanoscience and nanotechnology. Herein, we demonstrate that ultrathin CsPbBr3 perovskite nanosheets (NSs) can be obtained by a simple mixing of precursor-ligand complexes under ambient conditions. It was found that the formation of NSs is ascribed to the stepwise self-assembly of the initially formed different types of ultrathin nanostructures. Due to the disappearance of grain boundaries and protection of branched ligands, these NSs exhibit enhanced optical properties compared to other types of samples. This direct synthesis method opens up a promising road for the synthesis of ultrathin NSs and guides the fabrication of other ultrathin nanostructures.
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http://dx.doi.org/10.1039/d0dt04203jDOI Listing
March 2021

Pressure-Driven Transformation of CsPbBrI Nanoparticles into Stable Nanosheets in Solution through Self-Assembly.

J Phys Chem Lett 2020 Nov 10;11(22):9862-9868. Epub 2020 Nov 10.

Belarusian State University of Informatics and Radioelectronics, P. Browki St. 6, 220013 Minsk, Belarus.

Very recently, two-dimensional (2D) perovskite nanosheets (PNSs), taking the advantages of perovskite as well as the 2D structure properties, have received an enormous level of interest throughout the scientific community. In spite of this incredible success in perovskite nanocrystals (NCs), self-assembly of many nanostructures in metal halide perovskites has not yet been realized, and producing highly efficient red-emitting PNSs remains challenging. In this Letter, we show that by using CsPbBrI perovskite nanoparticles (NPs) as a building block, PNSs can emerge spontaneously under high ambient pressure via template-free self-assembly without additional complicated operation. It is found that the formation of PNSs is ascribed to the high pressure that provides the driving force for the alignment of NPs in solution. Because of the disappearance of the grain boundaries between the adjacent NPs and increased crystallinity, these PNSs self-assembled from NPs exhibit enhanced properties compared to the initial NPs, including higher PL intensity and remarkable chemical stability toward light and water.
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http://dx.doi.org/10.1021/acs.jpclett.0c02747DOI Listing
November 2020

Highly stable Na: CsPb(Br,I)@AlO nanocomposites prepared by a pre-protection strategy.

Nanoscale 2020 Mar;12(11):6403-6410

Belarusian State University of Informatics and Radioelectronics, P. Browki St. 6, 220013 Minsk, Belarus.

Among the leading energy materials, metal tri-halide perovskite quantum dots (PQDs) with outstanding optoelectronic properties are at the forefront of current research. However, enormous challenges remain to be addressed, including hazardous components and poor stability, before achieving practical applications of PQDs. Although there are diverse methods to improve the stability of PQDs, it is of central importance to avoid damage during operation. Herein, we develop a pre-protected strategy in which the coating combines the advantages of doping with sodium ions to jointly improve stability. Because the stable Na-rich surface acts as a defence, it protects the PQDs from damage during the coating process; therefore, they retain their initial fluorescence. When employing these Na-rich PQDs as core materials of a coating, the highly fluorescent Na: CsPb(Br,I)[email protected] nanocomposites can maintain good stability even when directly immersed in water or exposed to illumination. Clearly, the combination of these features sheds light on the stabilization and applications of PQDs.
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http://dx.doi.org/10.1039/d0nr00069hDOI Listing
March 2020

Reversible transformation between CsPbBr nanowires and nanoparticles.

Chem Commun (Camb) 2019 Nov 9;55(85):12809-12812. Epub 2019 Oct 9.

Belarusian State University of Informatics and Radioelectronics, P. Browki St. 6, 220013 Minsk, Belarus.

We show that CsPbBr nanowires (NWs) are formed by the hierarchical arrangement of individual nanoparticles (NPs), and reversible transformation from NWs to NPs is also achieved by anion exchange.
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http://dx.doi.org/10.1039/c9cc06123aDOI Listing
November 2019

G2019S Variation in LRRK2: An Ideal Model for the Study of Parkinson's Disease?

Front Hum Neurosci 2019 4;13:306. Epub 2019 Sep 4.

Department of Blood Supply, Yantai Center Blood Station, Yantai, China.

Parkinson's disease (PD) is the second most common neurodegenerative disorder and has plagued humans for more than 200 years. The etiology and detailed pathogenesis of PD is unclear, but is currently believed to be the result of the interaction between genetic and environmental factors. Studies have found that PD patients with the LRRK2:G2019S variation have the typical clinical manifestations of PD, which may be familial or sporadic, and have age-dependent pathogenic characteristics. Therefore, the LRRK2:G2019S variation may be an ideal model to study the interaction of multiple factors such as genetic, environmental and natural aging factors in PD in the future. This article reviewed the progress of LRRK2:G2019S studies in PD research in order to provide new research ideas and directions for the pathogenesis and treatment of PD.
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http://dx.doi.org/10.3389/fnhum.2019.00306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738350PMC
September 2019

Development and Internal Validation of a Prediction Model to Estimate the Probability of Left-Ventricular Diastolic Dysfunction in Stable Maintenance Hemodialysis Patients without Clinical Heart Failure.

Nephron 2019 2;142(4):301-310. Epub 2019 May 2.

Department of Nephrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Objective: To develop and internally validate a multivariable prediction model based on simple clinical record data and laboratory tests and to estimate the probability of left-ventricular diastolic dysfunction (LVDD) in stable maintenance hemodialysis (MHD) patients without clinical heart failure.

Design: Cross-sectional study.

Setting And Participants: In all, 181 patients on MHD without clinical heart failure were eligible from the dialysis center of Tongren Hospital, Shanghai Jiao Tong University School of Medicine between October 2017 and September 2018.

Outcomes: LVDD detected by echocardiography.

Measurements: We performed multivariable logistic regression using demographic, clinical, and laboratory data to identify predictors of LVDD with internal validation by using 200 bootstrap replications.

Results: Overall, 78 out of 181 (43.1%) patients were affected by LVDD. Predictors included in the LVDD Model were high-sensitive cardiac troponin T (OR 5.91 per 1-ln unit; 95% CI 2.17-16.13), B-type natriuretic peptide (OR 2.35 per 1-ln unit; 95% CI 1.14-4.86), and dialysis vintage (OR 1.04 per 1-month; 95% CI 1.01-1.07). The area (AUC) under the receiver operating characteristic curve of the Model was 0.871 (95% CI 0.811-0.932, p < 0.001). The calibration plot showed good agreement between predicted and observed probabilities with a calibration slope of 1.023 and intercept of -0.010. After internal validation, the Model maintained excellent discrimination (AUC 0.858, 95% CI 0.798-0.919) and good calibration (slope of 1.079, 95% CI 1.058-1.097 and intercept of -0.120, 95% CI -0.142 to -0.093). LVDD Model <0.23 can be used to rule out (sensitivity = 87.3%, negative likelihood ratio = 12.7%) and ≥0.44 can be used to rule in (specificity = 87.6%, positive likelihood ratio = 12.4%) echocardiography diagnosed LVDD.

Limitation: External validation of the Model will be required.

Conclusions: A model using routinely available simple clinical record data and laboratory tests can accurately predict the risk of LVDD in stable MHD patients. The Model and its cutoff values may be useful for early diagnosis and intervention of LVDD.
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http://dx.doi.org/10.1159/000499605DOI Listing
September 2020

Efficacy and Safety of Amphotericin B with Autologous Serum for Fungal Corneal Ulcer.

J Coll Physicians Surg Pak 2019 Feb;29(2):133-136

Department of Medical Record, Jinan Bus Hospital, Shandong Province, 250000, China.

Objective: To observe the clinical efficacy and safety of injection therapy of amphotericin B combined with autologous serum in the treatment of fungal corneal ulcer.

Study Design: An experimental study.

Place And Duration Of Study: Department of Ophthalmology, Jinan Second People's Hospital, Shandong Province, China, from July 2013 to June 2017.

Methodology: Patients diagnosed with monocular fungal corneal ulcer were divided randomly into observation group and control group, 48 cases in each group. Control group was treated with amphotericin B alone. Observation group was treated with autologous serum injection on the basis of the control group treatment. The improvement time of clinical symptoms such as hypopyon, corneal ulcer, foreign body sensation and photophobia were observed in two groups. The clinical efficacy and adverse reactions were compared between the two groups.

Results: The total effective rate of the observation group was higher than that of the control group (p=0.011). After treatment, the improvement time of the symptoms such as hypopyon, corneal ulcer, foreign body sensation, and photophobia was shorter in the observation group than the control group (all p <0.001). There was no significant difference in adverse reaction rate between the two groups (p=0.557).

Conclusion: Injection therapy of amphotericin B combined with autologous serum has significant efficacy for fungal corneal ulcer, which can effectively improve the clinical symptoms with fewer adverse reactions and safe and reliable results, thus worthy of promotion.
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http://dx.doi.org/10.29271/jcpsp.2019.02.133DOI Listing
February 2019

LINC00520 targeting miR-27b-3p regulates OSMR expression level to promote acute kidney injury development through the PI3K/AKT signaling pathway.

J Cell Physiol 2019 08 26;234(8):14221-14233. Epub 2019 Jan 26.

Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China.

Background: Acute kidney injury (AKI) shows several kinds of disorders, which acutely harm the kidney. However, the current medical methods have limited therapeutic effects. The present study aimed to find out the molecular mechanism of AKI pathogenesis, which may provide new insights for future therapy.

Methods: Bioinformatic analysis was conducted using the R language (AT&T BellLaboratories, University of Auckland, New Zealand) to acquire the differentially expressed long noncoding RNAs (lncRNAs) and messenger RNAs (mRNAs) in AKI. The expression levels of RNAs and related proteins in tissues and cells were detected by quantitative real-time PCR (qRT-PCR) and western blot. Dual-luciferase reporter gene assays were performed to verify the target relationship between microRNA (miRNA) and lncRNA as well as miRNA and mRNA. Flow cytometry and tunnel assay were used to detect the cell apoptotic rate in AKI.

Results: LINC00520, miR-27b-3p, and OSMR form an axis to regulate AKI. Knockdown of LINC00520 reduced acute renal injury both in vitro and in vivo. LINC00520 activated the PI3K/AKT pathway to aggravate renal ischemia/reperfusion injury, while upregulation of miR-27b-3p or downregulation of OSMR could accelerate the recovery of AKI.

Conclusion: Overexpression of LINC00520 contributes to the aggravation of AKI by targeting miR-27b-3p/ OSMR.
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http://dx.doi.org/10.1002/jcp.28118DOI Listing
August 2019

Congenital internal carotid artery hypoplasia: Case report.

Medicine (Baltimore) 2019 Jan;98(1):e13986

Department of Neurology.

Rationale: Congenital internal carotid artery hypoplasia (CICAH) is rarely reported. This study aimed to discuss the epidemiological characteristics, clinical manifestation, imaging and treatment of CICAH.

Patient Concerns: The case was male who showed barylalia and limited abilities of the left limbs as their main clinical manifestation. This patient was diagnosed CICAH by digital subtraction angiography (DSA) and computed tomography (CT).

Diagnosis: CICAH.

Interventions: The patient underwent anti platelet aggregation, lipid-lowering, improving cerebral circulation.

Outcomes: The patient was in a stable condition after management of cerebrovascular risk.

Lessons: Given the asymptomatic and congenital nature of carotid agenesis, no treatment is necessary or possible to re-establish the internal carotid artery (ICA). However, with the high risk of aneurysm and cerebrovascular insufficiency, management of cerebrovascular risk is important. Urgent radiological assessment is necessary for patients with suspicious neurological symptoms.
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http://dx.doi.org/10.1097/MD.0000000000013986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344190PMC
January 2019

High-sensitive cardiac troponin T: a biomarker of left-ventricular diastolic dysfunction in hemodialysis patients.

J Nephrol 2018 Dec 22;31(6):967-973. Epub 2018 Oct 22.

Department of Nephrology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.

Objective: To identify the relationship between serum high-sensitive cardiac troponin T (hs-cTnT) and left ventricular diastolic dysfunction (LVDD) among maintenance hemodialysis patients and to further explore the value of hs-cTnT in evaluating and predicting LVDD in this special group of patients.

Methods: In a cross-sectional study, 152 dialysis patients with end-stage renal disease (ESRD) underwent Hs-cTnT measurement using the high sensitivity assay. Echocardiography measurements were carried out according to the American Society of Echocardiography recommendations and E/E' > 15 or E' < 7 cm/s was defined as diastolic dysfunction. Demographic, biochemical, and echocardiographic values of left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), left atrial diameter, early/late peak velocities ratio (E/A), early peak diastolic annular velocity (E') and E/E' were compared across quartiles of hs-cTnT. The association of plasma hs-cTnT concentrations with echocardiographic parameters was analyzed by Spearman's correlation. The relationship between serum hs-cTnT and LVDD parameters of E/E' and E' was analyzed using multivariate regression analysis, and the value of hs-cTnT on assessing LVDD was evaluated by receiver-operating characteristic (ROC) curves.

Results: The median value of hs-cTnT was 45 pg/ml (range 28-73). All patients had detectable hs-cTnT, while 88% had greater hs-cTnT than the 99th percentile of the general population (14 pg/ml). Serum hs-cTnT values showed a significantly positive correlation with E/E' (r = 0.739, p < 0.001) and LVMI (r = 0.608, p < 0.001), but showed a negative correlation with E' (r = - 0.554, p < 0.001). Serum hs-cTnT was not associated with LV systolic dysfunction. The associations of hs-cTnT with E/E' and E' persisted after multivariate adjustment for LVMI and comorbidities. In logistic multiple regression analysis, compared with the lowest quartile of hs-cTnT, the highest two quartiles were approximately 5 and 11 times more likely to have E/E' > 15 and 7 and 17 times more likely to have E' < 7 cm/s. The area under the ROC curve for hs-cTnT evaluating E/E' > 15 was 0.847 and evaluating E' < 7 cm/s was 0.799, which denoted a moderate accuracy.

Conclusions: Our studies suggest that serum hs-cTnT may serve as a biomarker of LVDD in hemodialysis patients.
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http://dx.doi.org/10.1007/s40620-018-0540-0DOI Listing
December 2018

Evaluation of the drug effect and rational use of antiseptic drugs in outpatient and emergency department of hospital.

Pak J Pharm Sci 2018 Jul;31(4(Special)):1701-1705

Department of Nephrology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, China.

With the popularization and application of antiseptic drugs, the abuse of antiseptic drugs and various unreasonable applications have also become a serious medical problem. The prescriptions of antibiotics in our hospital were randomly selected for statistical analysis. Further, we analyzed the various situations of the use of antibiotics in outpatient department, and calculated the DDDs of different drugs based on the defined daily dose (DDD). The results showed that there were 403 unreasonable prescriptions, accounting for 24.9% of the drug prescriptions. The main problems of irrational prescriptions were unsuitable drugs, non indications and improper frequency of administration, which accounted for 27.1%, 21.3% and 18.3%. It is suggested that the quality department of the hospital should strengthen the special training for rational use of antimicrobial agents, intervene in time and effectively, and gradually change post evaluation into prevention and intervention in advance.
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July 2018

Sclerostin as a new key factor in vascular calcification in chronic kidney disease stages 3 and 4.

Int Urol Nephrol 2016 Dec 27;48(12):2043-2050. Epub 2016 Jul 27.

Department of Nephrology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, 264000, Shandong, China.

Background: Sclerostin is an osteocyte-derived inhibitor of the Wnt pathway and has been shown to play a key role in chronic kidney disease-mineral and bone disorder (CKD-MBD). The present study aimed to validate its potential as a predictor of vascular calcification in patients with CKD stages 3-4.

Methods: A total of 97 patients with CKD stages 3-4 were enrolled in this cross-sectional study. Routine clinical biochemistry tests and assays for sclerostin and mineral metabolism markers were performed. Additionally, vascular calcification was assessed by multislice spiral computed tomography. Logistic regression analyses were used to study the relationships between sclerostin and vascular calcification.

Results: Serum sclerostin levels (30.8 ± 6.4 vs. 41.7 ± 12.6 pmol/L, P < 0.05) were significantly elevated in patients with CKD stage 3a compared to in controls and increased with the decline in glomerular filtration rates. Furthermore, patients with vascular calcification had higher serum sclerostin levels. Patients with sclerostin levels above the median value had increased the prevalence of vascular calcification. Multivariate analysis revealed that sclerostin levels were positively associated with vascular calcification.

Conclusion: Our data indicate that sclerostin levels are elevated in patients with CKD and are associated with vascular calcification. Therefore, sclerostin may be used as a predictor of vascular calcification in the clinical setting.
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http://dx.doi.org/10.1007/s11255-016-1379-8DOI Listing
December 2016

Controllable optoelectric composite logic gates based on the polarization switching in an optically injected VCSEL: erratum.

Opt Express 2015 Nov;23(24):31295

A number of erratums are presented to correct the inadvertent typing mistakes in our paper.
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http://dx.doi.org/10.1364/OE.23.031295DOI Listing
November 2015

Controllable optoelectric composite logic gates based on the polarization switching in an optically injected VCSEL.

Opt Express 2015 Nov;23(23):29823-33

Based on the polarization switching mechanism in an optically injected vertical cavity surface emitting laser (VCSEL), and the new electro-optic modulation theory, we propose a novel approach to implement optoelectric logic gates. Here, the two linearly polarized lights from the output of the laser are considered as two logic outputs. Under the electro-optic modulation, one of the logic outputs is the NOT operation with the other one. With the same logic input signal, we perform various digital signal processing (AND, OR, XNOR, NAND, NOR and XOR) in the optical domain, controlling the logic operation of the applied electric field between the two logic input signals. On this basis, the logic operation of half-adder is further implemented.
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http://dx.doi.org/10.1364/OE.23.029823DOI Listing
November 2015

Protective effects of leflunomide on renal lesions in a rat model if diabetic nephropathy.

Ren Fail 2016 29;38(1):124-30. Epub 2015 Oct 29.

a Department of Nephrology , Yantai Yuhuangding Hospital, Qingdao University Medical School , Yantai , Shandong , China.

Diabetic nephropathy is one of the most common chronic complications of diabetes with poor efficacy of clinical treatment. This study investigated the protective effects of leflunomide, a new immunosuppressant, on tubulointerstitial lesions in a rat model of diabetic nephropathy. Diabetes was induced with streptozotocin (STZ, 50 mg/kg) by intraperitoneal injection in male Wistar rats. Two weeks after STZ injection, diabetic rats were treated daily for 8 weeks with low (5 mg/kg) and high dose (10 mg/kg) of leflunomide, and benazepril hydrochloride (4 mg/kg) as a positive control. In diabetic rats, the 24-h urine volume, urine protein and microalbumin, blood creatinine and urea nitrogen significantly increased, which were attenuated by leflunomide treatment in a dose-dependent manner (all p < 0.05). The increase of kidney weight/body weight and the histopathological findings of tubulointerstitial lesion in diabetic rats were mitigated by leflunomide treatment. Immunohistochemistry study and real-time polymerase chain reaction results demonstrated that osteopontin (OPN), transforming growth factor beta 1 (TGF-β1), α-smooth muscle actin and CD68 expression in the renal tubulointerstitial region were significantly increased in the diabetic rats, while these increases were inhibited by leflunomide treatment. These findings suggest that leflunomide protects the kidney injury of diabetic rats might through its inhibition of OPN/TGF-β1 mediated extracellular matrix deposition and tubulointerstitial fibrosis, as well as its inhibition on tubular epithelial-myofibroblast transdifferentiation.
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http://dx.doi.org/10.3109/0886022X.2015.1105024DOI Listing
January 2017

Characterization of rice black-streaked dwarf virus- and rice stripe virus-derived siRNAs in singly and doubly infected insect vector Laodelphax striatellus.

PLoS One 2013 11;8(6):e66007. Epub 2013 Jun 11.

State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control, Ministry of Agriculture Key Laboratory of Biotechnology in Plant Protection, Institute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, Zhejiang Province, China.

Replication of RNA viruses in insect cells triggers an antiviral defense that is mediated by RNA interference (RNAi) which generates viral-derived small interfering RNAs (siRNAs). However, it is not known whether an antiviral RNAi response is also induced in insects by reoviruses, whose double-stranded RNA genome replication is thought to occur within core particles. Deep sequencing of small RNAs showed that when the small brown planthopper (Laodelphax striatellus) was infected by Rice black-streaked dwarf virus (RBSDV) (Reoviridae; Fijivirus), more viral-derived siRNAs accumulated than when the vector insect was infected by Rice stripe virus (RSV), a negative single-stranded RNA virus. RBSDV siRNAs were predominantly 21 and 22 nucleotides long and there were almost equal numbers of positive and negative sense. RBSDV siRNAs were frequently generated from hotspots in the 5'- and 3'-terminal regions of viral genome segments but these hotspots were not associated with any predicted RNA secondary structures. Under laboratory condition, L. striatellus can be infected simultaneously with RBSDV and RSV. Double infection enhanced the accumulation of particular genome segments but not viral coat protein of RBSDV and correlated with an increase in the abundance of siRNAs derived from RBSDV. The results of this study suggest that reovirus replication in its insect vector potentially induces an RNAi-mediated antiviral response.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0066007PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679040PMC
January 2014

Ultrasound-guided percutaneous renal biopsy-induced accessory renal artery bleeding in an amyloidosis patient.

Diagn Pathol 2012 Dec 11;7:176. Epub 2012 Dec 11.

Department of Nephrology, Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai 264000, China.

Unlabelled: Ultrasound-guided percutaneous renal biopsy is an important technique for diagnosis of glomerular diseases, and the biopsy-induced life-threatening bleeding rarely happens. Primary systemic amyloidosis is a rare disease which may lead to organ dysfunction including arterial stiffness. The accessory renal artery is a kind of renal vascular variation which goes into the renal parenchyma directly or via the renal hilum. Here we reported a rare case of percutaneous renal biopsy-induced accessory renal artery life-threatening bleeding in a renal amyloidosis patient, and our experience of successful rescue in this patient.

Virtual Slides: http://www.diagnosticpathology.diagnomx.eu/vs/1524207344817819.
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http://dx.doi.org/10.1186/1746-1596-7-176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564814PMC
December 2012

Microregion detection of ionic liquid microemulsions.

J Colloid Interface Sci 2006 Sep 12;301(2):612-6. Epub 2006 Jun 12.

Key Laboratory of Colloid and Interface Chemistry (Shandong University), Ministry of Education, Jinan 250100, China.

Nonaqueous ionic liquid (IL) microemulsion consisting of IL, 1-butyl-3-methylimidazolium tetrafluoroborate (bmimBF(4)), surfactant TX-100, and toluene was prepared and the phase behavior of the ternary system was investigated. Electrical conductivity measurement was used for investigating the microregions of the nonaqueous IL microemulsions. On the basis of the percolation theory, the bmimBF(4)-in-toluene (IL/O), bicontinuous, and toluene-in-bmimBF(4) (O/IL) microregions of the microemulsions were successfully identified using insulative toluene as the titration phase. However, this method was invalid when conductive bmimBF(4) acted as the titration phase. The microregions obtained by conductivity measurements were further proved by electrochemical cyclic voltammetry experiments. The results indicated that the conductivity method was feasible for identifying microstructures of the nonaqueous IL microemulsions.
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http://dx.doi.org/10.1016/j.jcis.2006.05.010DOI Listing
September 2006
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