Yongju Lu

Yongju Lu

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Yongju Lu

Publications by authors named "Yongju Lu"

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Characterization of Arsenic-Induced Cancer Stem-Like Cells.

Methods Mol Biol 2020 ;2117:293-303

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

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http://dx.doi.org/10.1007/978-1-0716-0301-7_19DOI Listing
January 2020

Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells.

Semin Cancer Biol 2019 08 19;57:10-18. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI, 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690805PMC
August 2019

Proteomic Characterization of the World Trade Center dust-activated mdig and c-myc signaling circuit linked to multiple myeloma.

Sci Rep 2016 11 11;6:36305. Epub 2016 Nov 11.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1038/srep36305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5105131PMC
November 2016

The proteomic investigation reveals interaction of mdig protein with the machinery of DNA double-strand break repair.

Oncotarget 2015 Sep;6(29):28269-81

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

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http://dx.doi.org/10.18632/oncotarget.4961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695059PMC
September 2015

Filamin A phosphorylation by Akt promotes cell migration in response to arsenic.

Oncotarget 2015 May;6(14):12009-19

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

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http://www.oncotarget.com/fulltext/3617
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494919PMC
http://dx.doi.org/10.18632/oncotarget.3617DOI Listing
May 2015

Gene expression profile of human lung epithelial cells chronically exposed to single-walled carbon nanotubes.

Nanoscale Res Lett 2015 27;10:12. Epub 2015 Jan 27.

Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 USA.

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http://dx.doi.org/10.1186/s11671-014-0707-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314466PMC
April 2015

Oncoprotein mdig contributes to silica-induced pulmonary fibrosis by altering balance between Th17 and Treg T cells.

Oncotarget 2015 Feb;6(6):3722-36

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414149PMC
http://dx.doi.org/10.18632/oncotarget.2914DOI Listing
February 2015

Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion.

PLoS One 2014 4;9(2):e87998. Epub 2014 Feb 4.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy, Wayne State University, Detroit, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087998PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913710PMC
September 2014

Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation.

Cancer Lett 2014 May 14;346(2):257-63. Epub 2014 Jan 14.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976992PMC
May 2014

Reactive oxygen species contribute to arsenic-induced EZH2 phosphorylation in human bronchial epithelial cells and lung cancer cells.

Toxicol Appl Pharmacol 2014 May 25;276(3):165-70. Epub 2014 Feb 25.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA,. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2014.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401465PMC
May 2014

Arsenic-induced sub-lethal stress reprograms human bronchial epithelial cells to CD61¯ cancer stem cells.

Oncotarget 2014 Mar;5(5):1290-303

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA.

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http://www.oncotarget.com/fulltext/1789
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012730PMC
http://dx.doi.org/10.18632/oncotarget.1789DOI Listing
March 2014

Increased expression of mdig predicts poorer survival of the breast cancer patients.

Gene 2014 Feb 3;535(2):218-24. Epub 2013 Dec 3.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, 259 Mack Avenue, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2013.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3976998PMC
February 2014

Mdig de-represses H19 large intergenic non-coding RNA (lincRNA) by down-regulating H3K9me3 and heterochromatin.

Oncotarget 2013 Sep;4(9):1427-37

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy, Wayne State University, 259 Mack Avenue, Detroit, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824531PMC
http://dx.doi.org/10.18632/oncotarget.1155DOI Listing
September 2013

Reactive oxygen species-mediated p38 MAPK regulates carbon nanotube-induced fibrogenic and angiogenic responses.

Nanotoxicology 2013 Mar 20;7(2):157-68. Epub 2012 Jan 20.

Department of Pharmaceutical Sciences, Hampton University, Hampton, VA 23668, USA.

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http://dx.doi.org/10.3109/17435390.2011.647929DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089498PMC
March 2013

JNK and STAT3 signaling pathways converge on Akt-mediated phosphorylation of EZH2 in bronchial epithelial cells induced by arsenic.

Cell Cycle 2013 Jan 19;12(1):112-21. Epub 2012 Dec 19.

Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA.

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http://dx.doi.org/10.4161/cc.23030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570498PMC
January 2013

JNK-dependent Stat3 phosphorylation contributes to Akt activation in response to arsenic exposure.

Toxicol Sci 2012 Oct 13;129(2):363-71. Epub 2012 Jun 13.

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1093/toxsci/kfs199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3529643PMC
October 2012

Carbon nanotubes induce malignant transformation and tumorigenesis of human lung epithelial cells.

Nano Lett 2011 Jul 9;11(7):2796-803. Epub 2011 Jun 9.

Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, United States.

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http://dx.doi.org/10.1021/nl2011214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135732PMC
July 2011

Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.

Am J Respir Cell Mol Biol 2010 May 25;42(5):578-85. Epub 2009 Jun 25.

Department of Pharmaceutical Sciences, Hampton University, Hampton, Virginia 23668, USA.

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http://dx.doi.org/10.1165/rcmb.2009-0094OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874443PMC
May 2010

Phosphatidylinositol-3-kinase/akt regulates bleomycin-induced fibroblast proliferation and collagen production.

Am J Respir Cell Mol Biol 2010 Apr 11;42(4):432-41. Epub 2009 Jun 11.

West Virginia University, Department of Pharmaceutical Sciences, P.O. Box 9530, Morgantown, WV 26506, USA.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2009-0002OC
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http://dx.doi.org/10.1165/rcmb.2009-0002OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848736PMC
April 2010

Direct fibrogenic effects of dispersed single-walled carbon nanotubes on human lung fibroblasts.

J Toxicol Environ Health A 2010 ;73(5):410-22

National Institute for Occupational Safety and Health, HELD/PPRB, Morgantown, West Virginia 26505, USA.

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http://dx.doi.org/10.1080/15287390903486550DOI Listing
March 2010

Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin.

Int J Oncol 2010 Jan;36(1):59-67

Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.

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January 2010

Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3.

Cell Cycle 2009 Jul 5;8(13):2101-9. Epub 2009 Jul 5.

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.

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http://dx.doi.org/10.4161/cc.8.13.8927DOI Listing
July 2009

Dependence of reactive oxygen species and FLICE inhibitory protein on lipofectamine-induced apoptosis in human lung epithelial cells.

J Pharmacol Exp Ther 2008 Jun 19;325(3):969-77. Epub 2008 Mar 19.

Department of Pharmaceutical Sciences, West Virginia University, Morgantown, West Virginia 26506, USA.

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http://dx.doi.org/10.1124/jpet.107.136077DOI Listing
June 2008

The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation.

J Immunol 2008 Mar;180(5):3072-80

Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833600PMC
http://dx.doi.org/10.4049/jimmunol.180.5.3072DOI Listing
March 2008

Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells.

Carcinogenesis 2007 Oct 23;28(10):2218-26. Epub 2007 May 23.

Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA.

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http://dx.doi.org/10.1093/carcin/bgm115DOI Listing
October 2007

Antioxidant activity of Vaccinium stamineum: exhibition of anticancer capability in human lung and leukemia cells.

Planta Med 2007 May 29;73(5):451-60. Epub 2007 Mar 29.

Fruit Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, MD 20705-2350, USA.

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http://dx.doi.org/10.1055/s-2007-967164DOI Listing
May 2007

Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells.

J Biol Chem 2006 Dec 11;281(48):37142-9. Epub 2006 Sep 11.

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.

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http://dx.doi.org/10.1074/jbc.M603631200DOI Listing
December 2006

Cyanidin-3-glucoside, a natural product derived from blackberry, exhibits chemopreventive and chemotherapeutic activity.

J Biol Chem 2006 Jun 17;281(25):17359-68. Epub 2006 Apr 17.

Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.

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http://dx.doi.org/10.1074/jbc.M600861200DOI Listing
June 2006

Involvement of protein kinase C in crystalline silica-induced activation of the MAP kinase and AP-1 pathway.

Am J Physiol Lung Cell Mol Physiol 2006 Feb 16;290(2):L291-7. Epub 2005 Sep 16.

Pathology and Physiology Research Branch, NIOSH, 1095 Willowdale Rd., Morgantown, WV 26505, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00053.2005
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http://dx.doi.org/10.1152/ajplung.00053.2005DOI Listing
February 2006

Deficiency in Ikkbeta gene enhances arsenic-induced gadd45alpha expression.

Mol Cell Biochem 2005 Nov;279(1-2):163-8

Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, P.R. China.

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http://dx.doi.org/10.1007/s11010-005-8289-xDOI Listing
November 2005

The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer.

Oncogene 2005 Jul;24(31):4873-82

Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China.

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http://dx.doi.org/10.1038/sj.onc.1208668DOI Listing
July 2005

Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid.

J Biol Chem 2005 Jul 8;280(30):27888-95. Epub 2005 Jun 8.

Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M503347200
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http://dx.doi.org/10.1074/jbc.M503347200DOI Listing
July 2005

Inhibitory effect on activator protein-1, nuclear factor-kappaB, and cell transformation by extracts of strawberries (Fragaria x ananassa Duch.).

J Agric Food Chem 2005 May;53(10):4187-93

Fruit Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, Maryland 20705-2350, USA.

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http://dx.doi.org/10.1021/jf0478049DOI Listing
May 2005

Blackberry extracts inhibit activating protein 1 activation and cell transformation by perturbing the mitogenic signaling pathway.

Nutr Cancer 2004 ;50(1):80-9

Pathology and Physiology Research Branch, Helath Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.

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http://www.tandfonline.com/doi/abs/10.1207/s15327914nc5001_1
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http://dx.doi.org/10.1207/s15327914nc5001_11DOI Listing
April 2005

Essential role of p53 in silica-induced apoptosis.

Am J Physiol Lung Cell Mol Physiol 2005 Mar 19;288(3):L488-96. Epub 2004 Nov 19.

Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.

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http://dx.doi.org/10.1152/ajplung.00123.2003DOI Listing
March 2005

Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract.

J Biol Chem 2004 Mar 9;279(11):10670-6. Epub 2003 Dec 9.

Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M311465200
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http://dx.doi.org/10.1074/jbc.M311465200DOI Listing
March 2004

Protective roles of NF-kappa B for chromium(VI)-induced cytotoxicity is revealed by expression of Ikappa B kinase-beta mutant.

J Biol Chem 2002 Feb 28;277(5):3342-9. Epub 2001 Nov 28.

Health Effects Laboratory Division, NIOSH, Morgantown, West Virginia 26505, USA.

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http://dx.doi.org/10.1074/jbc.M101089200DOI Listing
February 2002

Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway.

Proc Natl Acad Sci U S A 2002 Feb 12;99(4):1990-5. Epub 2002 Feb 12.

Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA.

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http://dx.doi.org/10.1073/pnas.032428899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122307PMC
February 2002