Yonghong Wan

Yonghong Wan

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Yonghong Wan

Publications by authors named "Yonghong Wan"

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Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8 T-cell memory development.

Nat Cell Biol 2020 Jan 23;22(1):18-25. Epub 2019 Dec 23.

Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1038/s41556-019-0440-0DOI Listing
January 2020

Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity.

J Clin Invest 2019 02 18;129(2):518-530. Epub 2018 Dec 18.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI121004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355222PMC
February 2019

HDACi Delivery Reprograms Tumor-Infiltrating Myeloid Cells to Eliminate Antigen-Loss Variants.

Cell Rep 2018 07;24(3):642-654

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8N 3Z5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.040DOI Listing
July 2018

Preclinical development of peptide vaccination combined with oncolytic MG1-E6E7 for HPV-associated cancer.

Vaccine 2018 04 12;36(16):2181-2192. Epub 2018 Mar 12.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada; Turnstone Biologics, Ottawa, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183025
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http://dx.doi.org/10.1016/j.vaccine.2018.02.070DOI Listing
April 2018

A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8 T cells.

Nat Cell Biol 2018 01 11;20(1):21-27. Epub 2017 Dec 11.

Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1038/s41556-017-0002-2DOI Listing
January 2018

Customized Viral Immunotherapy for HPV-Associated Cancer.

Cancer Immunol Res 2017 10 14;5(10):847-859. Epub 2017 Sep 14.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0102DOI Listing
October 2017

Mechanistic insights into the oncolytic activity of vesicular stomatitis virus in cancer immunotherapy.

Oncolytic Virother 2015 15;4:157-67. Epub 2015 Oct 15.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.2147/OV.S66079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918393PMC
August 2016

High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells.

PLoS One 2016 11;11(4):e0153304. Epub 2016 Apr 11.

McMaster Immunology Research Center, Department of Pathology and Molecular Medicine, McMaster University, Michael G. DeGroote Center for Learning and Discovery, Hamilton, Ontario, Canada L8N 3Z5.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153304PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827838PMC
August 2016

Capitalizing on Cancer Specific Replication: Oncolytic Viruses as a Versatile Platform for the Enhancement of Cancer Immunotherapy Strategies.

Biomedicines 2016 Aug 24;4(3). Epub 2016 Aug 24.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.

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http://dx.doi.org/10.3390/biomedicines4030021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5344262PMC
August 2016

Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination.

J Immunol 2016 06 27;196(11):4587-95. Epub 2016 Apr 27.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario L8N 3Z5, Canada

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http://dx.doi.org/10.4049/jimmunol.1600106DOI Listing
June 2016

T Cells Engineered With Chimeric Antigen Receptors Targeting NKG2D Ligands Display Lethal Toxicity in Mice.

Mol Ther 2015 Oct 30;23(10):1600-10. Epub 2015 Jun 30.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S15250016163029
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http://dx.doi.org/10.1038/mt.2015.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817919PMC
October 2015

Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity.

Innate Immun 2015 Aug 5;21(6):626-34. Epub 2015 Mar 5.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada

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http://journals.sagepub.com/doi/10.1177/1753425915575078
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http://dx.doi.org/10.1177/1753425915575078DOI Listing
August 2015

Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling.

Cancer Immunol Res 2015 Feb 4;3(2):196-205. Epub 2014 Dec 4.

State Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0177DOI Listing
February 2015

Chemotherapy and Oncolytic Virotherapy: Advanced Tactics in the War against Cancer.

Front Oncol 2014 11;4:145. Epub 2014 Jun 11.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University , Hamilton, ON , Canada.

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http://dx.doi.org/10.3389/fonc.2014.00145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052116PMC
June 2014

Maraba virus as a potent oncolytic vaccine vector.

Mol Ther 2014 Feb 25;22(2):420-429. Epub 2013 Oct 25.

McMaster Immunology Research Center, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1038/mt.2013.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916044PMC
February 2014

Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.

J Immunol 2013 May 3;190(9):4795-804. Epub 2013 Apr 3.

Department of Pathology and Molecular Medicine, Farncombe Family Digestive Health Research Institute, Health Sciences Centre, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

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http://www.jimmunol.org/content/190/9/4795.full.pdf
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1201887
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http://dx.doi.org/10.4049/jimmunol.1201887DOI Listing
May 2013

Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses.

Blood 2013 Mar 16;121(13):2432-9. Epub 2013 Jan 16.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/blood-2012-06-438481DOI Listing
March 2013

Combined mTOR inhibition and OX40 agonism enhances CD8(+) T cell memory and protective immunity produced by recombinant adenovirus vaccines.

Mol Ther 2012 Apr 20;20(4):860-9. Epub 2011 Dec 20.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2011.281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321597PMC
April 2012

Engineering dendritic cells to enhance cancer immunotherapy.

Mol Ther 2011 May 5;19(5):841-53. Epub 2011 Apr 5.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2011.57DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098642PMC
May 2011

IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells.

Cancer Res 2011 Apr 9;71(7):2497-506. Epub 2011 Feb 9.

Department of Pathology and Molecular Medicine and Medical Sciences Program, McMaster University, Hamilton, Ontario, Canada.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-3025DOI Listing
April 2011

Tolerogenic dendritic cells and their potential applications.

Authors:
Jim Hu Yonghong Wan

Immunology 2011 Mar 5;132(3):307-14. Epub 2011 Jan 5.

Physiology and Experimental Medicine Research Program, Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada.

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http://dx.doi.org/10.1111/j.1365-2567.2010.03396.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044897PMC
March 2011

Adaptive antiviral immunity is a determinant of the therapeutic success of oncolytic virotherapy.

Mol Ther 2011 Feb 30;19(2):335-44. Epub 2010 Nov 30.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2010.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034857PMC
February 2011

Potentiating cancer immunotherapy using an oncolytic virus.

Mol Ther 2010 Aug 15;18(8):1430-9. Epub 2010 Jun 15.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2010.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927075PMC
August 2010

Processing of tumor antigen differentially impacts the development of helper and effector CD4+ T-cell responses.

Mol Ther 2010 Jun 23;18(6):1224-32. Epub 2010 Feb 23.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2010.30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889742PMC
June 2010

Immunotherapy can reject intracranial tumor cells without damaging the brain despite sharing the target antigen.

J Immunol 2010 Apr 17;184(8):4269-75. Epub 2010 Mar 17.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.0901447DOI Listing
April 2010

Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cells.

Cancer Immunol Immunother 2010 Feb;59(2):313-21

Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, The People's Republic of China.

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http://dx.doi.org/10.1007/s00262-009-0752-1DOI Listing
February 2010

Persistence of transgene expression influences CD8+ T-cell expansion and maintenance following immunization with recombinant adenovirus.

J Virol 2009 Dec 16;83(23):12027-36. Epub 2009 Sep 16.

Department of Pathology and Molecular Medicine, McMaster University, Center for Gene Therapeutics, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1128/JVI.00593-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786755PMC
December 2009

Vesicular stomatitis virus as a novel cancer vaccine vector to prime antitumor immunity amenable to rapid boosting with adenovirus.

Mol Ther 2009 Oct 14;17(10):1814-21. Epub 2009 Jul 14.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1038/mt.2009.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835010PMC
October 2009

CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis.

Eur J Immunol 2009 May;39(5):1252-9

Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada.

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http://dx.doi.org/10.1002/eji.200839152DOI Listing
May 2009

Neoadjuvant vaccination provides superior protection against tumor relapse following surgery compared with adjuvant vaccination.

Cancer Res 2009 May 21;69(9):3979-85. Epub 2009 Apr 21.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3385DOI Listing
May 2009

Mucosally delivered dendritic cells activate T cells independently of IL-12 and endogenous APCs.

J Immunol 2008 Aug;181(4):2356-67

Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, and M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.181.4.2356DOI Listing
August 2008

Culture of myeloid dendritic cells from bone marrow precursors.

J Vis Exp 2008 Jul 25(17). Epub 2008 Jul 25.

Medical Sciences Program, McMaster University.

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http://dx.doi.org/10.3791/769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253608PMC
July 2008

The magnitude of the CD8+ T cell response produced by recombinant virus vectors is a function of both the antigen and the vector.

Cell Immunol 2007 Nov-Dec;250(1-2):55-67. Epub 2008 Mar 3.

Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Room MDCL-5025, 1200 Main Street West, Hamilton, Ont., Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.cellimm.2008.01.005DOI Listing
May 2008

Enhanced antitumor immunity elicited by dendritic cell vaccines is a result of their ability to engage both CTL and IFN gamma-producing NK cells.

Mol Ther 2008 Feb 4;16(2):411-8. Epub 2007 Dec 4.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.mt.6300347DOI Listing
February 2008

Enhanced Antitumor Immunity Elicited by Dendritic Cell Vaccines Is a Result of Their Ability to Engage Both CTL and IFNγ-producing NK Cells.

Mol Ther 2008 Feb 7;16(2):411-418. Epub 2016 Dec 7.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1038/sj.mt.6300347DOI Listing
February 2008

Enhanced protein expression by internal ribosomal entry site-driven mRNA translation as a novel approach for in vitro loading of dendritic cells with antigens.

Hum Immunol 2008 Jan 27;69(1):32-40. Epub 2007 Dec 27.

Department of Hematology, Beijing Military General Hospital, No. 6, DongSi, Beijing 100700, China.

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http://dx.doi.org/10.1016/j.humimm.2007.11.009DOI Listing
January 2008

Antigen presentation by exosomes released from peptide-pulsed dendritic cells is not suppressed by the presence of active CTL.

J Immunol 2007 Oct;179(8):5024-32

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.179.8.5024DOI Listing
October 2007

On the role of CD4+ T cells in the CD8+ T-cell response elicited by recombinant adenovirus vaccines.

Mol Ther 2007 May 20;15(5):997-1006. Epub 2007 Mar 20.

Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.mt.6300130DOI Listing
May 2007

Cigarette smoke impairs NK cell-dependent tumor immune surveillance.

J Immunol 2007 Jan;178(2):936-43

Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.178.2.936DOI Listing
January 2007

Development of cell-based tuberculosis vaccines: genetically modified dendritic cell vaccine is a much more potent activator of CD4 and CD8 T cells than peptide- or protein-loaded counterparts.

Mol Ther 2006 Apr 15;13(4):766-75. Epub 2005 Dec 15.

Department of Pathology and Molecular Medicine and Division of Infectious Diseases, Centre for Gene Therapeutics, McMaster University, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.ymthe.2005.10.018DOI Listing
April 2006

Recombinant adenovirus vaccines can successfully elicit CD8+ T cell immunity under conditions of extreme leukopenia.

Mol Ther 2006 Feb 16;13(2):270-9. Epub 2005 Nov 16.

Department of Pathology and Molecular Medicine, Center for Gene Therapeutics, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.ymthe.2005.09.018DOI Listing
February 2006

Recent advances in the development of adenovirus- and poxvirus-vectored tuberculosis vaccines.

Curr Gene Ther 2005 Oct;5(5):485-92

Infectious Diseases Division, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.2174/156652305774329230DOI Listing
October 2005

T-cell-mediated inflammation does not contribute to the maintenance of airway dysfunction in mice.

J Appl Physiol (1985) 2004 Dec 30;97(6):2258-65. Epub 2004 Jul 30.

Firestone Institute for Respiratory Health, Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1152/japplphysiol.00597.2004DOI Listing
December 2004

CTL-dependent and -independent antitumor immunity is determined by the tumor not the vaccine.

J Immunol 2004 May;172(9):5200-5

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.172.9.5200DOI Listing
May 2004

TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection.

J Clin Invest 2004 Feb;113(3):401-13

Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1172/JCI18991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC324534PMC
February 2004

Vaccination-induced autoimmune vitiligo is a consequence of secondary trauma to the skin.

Cancer Res 2004 Feb;64(4):1509-14

Department of Pathology and Molecular Medicine, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.

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http://dx.doi.org/10.1158/0008-5472.can-03-3227DOI Listing
February 2004

A phase I trial of adenovector-mediated delivery of interleukin-2 (AdIL-2) in high-risk localized prostate cancer.

Cancer Gene Ther 2003 Oct;10(10):755-63

1Division of Hematology-Oncology and Urology, The Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9.

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http://dx.doi.org/10.1038/sj.cgt.7700626DOI Listing
October 2003

High-dimensional architectures from the self-assembly of lanthanide ions with benzenedicarboxylates and 1,10-phenanthroline.

Inorg Chem 2003 Aug;42(16):4985-94

Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China.

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http://dx.doi.org/10.1021/ic034258cDOI Listing
August 2003

Adenoviral-mediated gene transfer of lymphotactin to the lungs of mice and rats results in infiltration and direct accumulation of CD4+, CD8+, and NK cells.

J Interferon Cytokine Res 2002 May;22(5):573-82

Division of Hematology-Oncology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://www.liebertpub.com/doi/10.1089/10799900252982052
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http://dx.doi.org/10.1089/10799900252982052DOI Listing
May 2002