Publications by authors named "Yonggang Wang"

434 Publications

Alcohol-impaired Walking in 16 Countries: A Theory-Based Investigation.

Accid Anal Prev 2021 Jun 4;159:106212. Epub 2021 Jun 4.

Chang'an University, China.

Alcohol is a global risk factor for road trauma. Although drink driving has received most of the scholarly attention, there is growing evidence of the risks of alcohol-impaired walking. Alcohol-impaired pedestrians are over-represented in fatal crashes compared to non-impaired pedestrians. Additionally, empirical evidence shows that alcohol intoxication impairs road-crossing judgements. Besides some limited early research, much is unknown about the global prevalence and determinants of alcohol-impaired walking. Understanding alcohol-impaired walking will support health promotion initiatives and injury prevention. The present investigation has three aims: (1) compare the prevalence of alcohol-impaired walking across countries; (2) identify international groups of pedestrians based on psychosocial factors (i.e., Theory of Planned Behaviour (TPB) and perceptions of risk); and (3) investigate how segments of pedestrians form their intention for alcohol-impaired walking using the extended TPB (i.e. subjective norm, attitudes, perceived control, and perceived risk). A cross-sectional design was applied. The target behaviour question was "have you been a pedestrian when your thinking or physical ability (balance/strength) is affected by alcohol?" to ensure comparability across countries. Cluster analysis based on the extended TPB was used to identify groups of countries. Finally, regressions were used to predict pedestrians' intentions per group. A total of 6,166 respondents (Age M(SD) = 29.4 (14.2); Males = 39.2%) completed the questionnaire, ranging from 12.6% from Russia to 2.2% from Finland. The proportion of participants who reported never engaging in alcohol-impaired walking in the last three months ranged from 30.1% (Spain) to 83.1% (Turkey). Four groups of countries were identified: group-1 (Czech Republic, Spain, and Australia), group-2 (Russia and Finland), group-3 (Japan), and group-4 (final ten countries including Colombia, China, and Romania). Pedestrian intentions to engage in alcohol- impaired walking are predicted by perceptions of risk and TPB-psychosocial factors in group-1 and group-4. Favourable TPB-beliefs and low perceived risk increased alcohol-impaired walking intentions. Conversely, subjective norms were not significant in group-2 and only perceived risk predicted intention in group-3. The willingness of pedestrians to walk when alcohol-impaired differs significantly across the countries in this study. Perceived risk was the only common predictor among the 16 countries.
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http://dx.doi.org/10.1016/j.aap.2021.106212DOI Listing
June 2021

Ultraflat Langmuir-Blodgett Assembled Graphene Oxide Saturable-Absorber Films for Pulsed Near-Infrared Laser Generation.

Nanotechnology 2021 Jun 2. Epub 2021 Jun 2.

Henan University, No. 1, Jinming Street, Kaifeng, 457004, CHINA.

Large-scale production of ultraflat broadband saturable-absorber films is highly desired for passive mode-locked solid-state lasers. However, the current vapour deposition and spin coating routes for fabricating saturable absorbers are suffering from the limited flexibility in substrate choice and complexity of mass production processes. Here, we demonstrate an ultraflat carboxyl-functionalized graphene oxide (GO-COOH) saturable absorber (SA) film via Langmuir-Blodgett (LB) assembly for solid state laser mode-locking. Hydrophilic carboxyl groups from GO sheets weaken the aggregation effect thus contribute to the uniform and stable dispersion of GO sheets in water. Such GO suspensions are made into an ultrathin large-area graphene-based SA film by a LB assembly process ensuring high surface uniformity. The room-temperature and highly repeated operation for GO LB films avoids the thermal damage of GO sheets and improves the membrane repeatability. Consequently, the ultrathin GO-COOH SA shows the modulation depth (2.3%) and low saturation intensity (24.7 KW/cm2) under 1064 nm laser irradiation. By inserting the GO SA into a Nd: GdVO4 laser, both passive Q-switched (QS) and passive Q-switched mode-locked (QML) operations are also attained. The slope efficiency of QS laser is up to 35.6% and the maximum single pulse energy is 1.48 μJ. In particular, the QML pulses can be achieved stably and repeatedly with an average output power of 1.33 W and a pulse energy of 13.2 nJ. Our strategy provides a new concept for improving the modulation stability of graphene-based SAs and promoting their industrial application in pulsed solid-state lasers.
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http://dx.doi.org/10.1088/1361-6528/ac074dDOI Listing
June 2021

Mechanochemical Synthesis of Pt/NbCT MXene Composites for Enhanced Electrocatalytic Hydrogen Evolution.

Materials (Basel) 2021 May 6;14(9). Epub 2021 May 6.

State Key Laboratory of New Ceramics and Fine Processing, School of Materials, Science and Engineering, Tsinghua University, Beijing 100084, China.

Production of hydrogen from water splitting has been considered as a promising solution for energy conversion and storage. Since a noble metal-based structure is still the most satisfactory but scarce kind of catalyst, it is significant to allow for practical application of such catalysts by engineering the heterogeneous structure and developing green and facile synthetic strategies. Herein, we report a mechanochemical ball milling synthesis of platinum nanoclusters immobilized on a 2D transition metal carbide MXene (NbCT) as an enhanced catalyst for hydrogen evolution. After annealing at 600 °C, ultrafine PtNb nanoclusters are formed on the Pt/NbCT catalyst. As prepared, the Pt/NbCT-600 catalyst demonstrates superior electrochemical HER activity and stability with an ultralow overpotential of 5 mV and 46 mV to achieve 10 mA cm and 100 mA cm, respectively, in comparison with other NbCT-based catalysts and commercial Pt/C catalysts. Moreover, the remarkable durability is also confirmed by accelerated durability tests (ADTs) and long-term chronoamperometry (CA) tests. The excellent HER performance was attributed to high Pt dispersion and more active site exposure by the mechanochemical process and thermal treatment. Such results suggest that the mechanochemical strategy provides a novel approach for rational design and cost-effective production of electrocatalysts, also providing other potential applications in a wide range of areas.
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http://dx.doi.org/10.3390/ma14092426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124981PMC
May 2021

Genomic structural equation modelling provides a whole-system approach for the future crop breeding.

Theor Appl Genet 2021 May 31. Epub 2021 May 31.

Western Crop Genetics Alliance, Agricultural Sciences, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, WA, Australia.

Key Message: Using genomic structural equation modelling, this research demonstrates an efficient way to identify genetically correlating traits and provides an effective proxy for multi-trait selection to consider the joint genetic architecture of multiple interacting traits in crop breeding. Breeding crop cultivars with optimal value across multiple traits has been a challenge, as traits may negatively correlate due to pleiotropy or genetic linkage. For example, grain yield and grain protein content correlate negatively with each other in cereal crops. Future crop breeding needs to be based on practical yet accurate evaluation and effective selection of beneficial trait to retain genes with the best agronomic score for multiple traits. Here, we test the framework of whole-system-based approach using structural equation modelling (SEM) to investigate how one trait affects others to guide the optimal selection of a combination of agronomically important traits. Using ten traits and genome-wide SNP profiles from a worldwide barley panel and SEM analysis, we revealed a network of interacting traits, in which tiller number contributes positively to both grain yield and protein content; we further identified common genetic factors affecting multiple traits in the network of interaction. Our method demonstrates an efficient way to identify genetically correlating traits and underlying pleiotropic genetic factors and provides an effective proxy for multi-trait selection within a whole-system framework that considers the joint genetic architecture of multiple interacting traits in crop breeding. Our findings suggest the promise of a whole-system approach to overcome challenges such as the negative correlation of grain yield and protein content to facilitating quantitative and objective breeding decisions in future crop breeding.
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http://dx.doi.org/10.1007/s00122-021-03865-4DOI Listing
May 2021

A general approach to realizing perovskite nanocrystals with insulating metal sulfate shells.

Nanoscale 2021 May 28. Epub 2021 May 28.

Experimental Center of Advanced Materials, School of Materials Science and Engineering, Beijing Institute of Technology, 5 Zhongguancun South Street, Beijing 100081, China.

The strategy of constructing the core/shell structure is of great importance in emitting semiconductor nanocrystals. However, the coating on soft metal halide perovskite nanocrystals at the single particle level remains a challenge because of the low compatibility between perovskites and common wide-band-gap semiconductors, such as ZnS and CdS. In addition, using these semiconductors as the shell layer requires high reaction temperatures, which often lead to undesirable chemical transformation. Herein we report a general route to passivate the perovskite nanocrystals by insulating metal sulfate shells. The passivating shell is created around the as-synthesized CsPbBr3 perovskite nanocrystals by initiating the reaction between an organic ammonium sulfate and a variety of metal ions in the presence of ligands. This new method allowed for creating insulating metal sulfate shells with controllable thicknesses and without unwanted chemical transformation. Importantly, these novel core/shell-structured nanocrystals show photoluminescence quantum yields near unity, highly suppressed energy transfer in film and suppressed halide exchange in solution.
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http://dx.doi.org/10.1039/d1nr01671gDOI Listing
May 2021

lncRNA TUG1 inhibits the cancer stem cell‑like properties of temozolomide‑resistant glioma cells by interacting with EZH2.

Mol Med Rep 2021 Jul 26;24(1). Epub 2021 May 26.

Department of Neurosurgery, First People's Hospital of Kunming, Kunming, Yunnan 650032, P.R. China.

Temozolomide (TMZ) is currently one of the first‑line drugs used for the treatment of high‑grade gliomas. However, TMZ resistance results in unsatisfactory therapeutic effects in gliomas. Cancer stem cells (CSCs) have recently been determined to serve a pivotal regulatory role in tumor metastasis, recurrence and chemoresistance. In addition, numerous reports have shown that long non‑coding RNAs (lncRNAs) exert an essential role in the occurrence and development of tumors, and can be used as biomarkers for tumor diagnosis and treatment. Among them, studies have revealed that taurine upregulated gene 1 (TUG1) exhibits an important regulatory effect on the malignant biological behavior of glioma cells. Moreover, it has been reported that enhancer of Zeste homolog 2 polycomb repressive complex subunit 2 (EZH2) promotes tumorigenesis, including in glioma. However, the underlying mechanism of the interaction of TUG1 and EZH2 with CSCs of glioma remains elusive, and thus requires further clarification. The present study aimed to explore the role of TUG1 and EZH2 in TMZ resistance in glioma. Cell Counting Kit‑8, colony formation,sphere formation and Annexin V‑FITC/PI assays were used to detect the proliferation, clone formation efficiency, stemness and apoptosis of TMZ‑resistant glioma cells. Xenograft tumor assay was used to detect the effect of TUG1 on the tumorigenesis of TMZ‑resistant glioma cells. The present findings demonstrated that TUG1 exhibited a low expression in glioma cells, while EZH2 expression was the opposite. Moreover, it was observed that A172/TMZ cells possessed higher CSCs‑like properties compared with parent cells, and that TUG1 and EZH2 were abnormally expressed in A172/TMZ cells. Knockdown of TUG1 or overexpression of EZH2 promoted A172/TMZ cell proliferation and CSCs‑like properties, as well as inhibited their apoptosis, thereby enhancing the TMZ resistance of A172/TMZ cells. Furthermore, it was found that TUG1 alleviated the TMZ resistance of A172/TMZ cells by inhibiting EZH2 expression. Of note, overexpression of TUG1 inhibited the tumorigenicity of A172/TMZ cells by downregulating EZH2 expression in vivo. Collectively, the present study demonstrated that TUG1 served an essential regulatory role in TMZ resistance of gliomas.
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http://dx.doi.org/10.3892/mmr.2021.12172DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8170197PMC
July 2021

Exceptional Cocatalyst-Free Photo-Enhanced Piezocatalytic Hydrogen Evolution of Carbon Nitride Nanosheets from Strong In-Plane Polarization.

Adv Mater 2021 May 8:e2101751. Epub 2021 May 8.

Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing, 100083, China.

Utilizing mechanical energy to produce hydrogen is emerging as a promising way to generate renewable energy, but is challenged by low efficiency and scanty cognition. In this work, graphitic carbon nitride (g-C N ) with an atomically thin sheet-like structure is applied for prominent piezocatalytic and photo-enhanced piezocatalytic H production. It is revealed that the anomalous piezoelectricity in g-C N originates from the strong in-plane polarization along the a-axis, contributed by the superimposed polar tri-s-triazine units and flexoelectric effect derived from the structured triangular cavities, which provides powerful electrochemical driving force for the water reduction reaction. Furthermore, the photo-enhanced charge transfer enables g-C N nanosheets to reserve more energized polarization charges to fully participate in the reaction at the surface reactive sites enriched by strain-induced carbon vacancies. Without any cocatalysts, an exceptional photo-piezocatalytic H evolution rate of 12.16 mmol g h is delivered by the g-C N nanosheets, far exceeding that of previously reported piezocatalysts and g-C N photocatalysts. Further, high pure-water-splitting performance with production of the value-added oxidation product H O via photo-piezocatalysis is also disclosed. This work not only exposes the potential of g-C N as a piezo-semiconductor for catalytic H evolution, but also breaks a new ground for the conversion of solar and mechanical energy by photomediated piezocatalytic reaction.
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http://dx.doi.org/10.1002/adma.202101751DOI Listing
May 2021

Fertility and early embryonic development toxicity assessment of naringin in Sprague-Dawley rats.

Regul Toxicol Pharmacol 2021 Apr 29;123:104938. Epub 2021 Apr 29.

Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed TCM, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, PR China. Electronic address:

Naringin is a dihydroflavonoid abundantly existed in grapefruit and related citrus species. The double directional adjusting function of estrogenic and anti-estrogenic activities of naringin and its aglycone naringenin has raised concern about possible risks of unwanted interference with endocrine regulation. Herein we assessed the safety of naringin on fertility and early embryonic development toxicity in Sprague-Dawley rats. Twenty-two male and 22 female rats per group were orally given naringin at 0, 50, 250, and 1250 mg/kg/day. Male rats were administered beginning 9 weeks prior to mating and continued until necropsy. Dosing to female began 2 weeks before mating and continued until gestation day 7. There were no obvious effects of naringin on physical signs, animal behavior, and survival rate, although female and male rats from 1250 mg/kg group had lower body weight and tended to have less food consumption. Importantly, no treatment-related effects of naringin were found in relation to fertility and early embryonic development. Under these experimental conditions, it was concluded that the no-observed-adverse-effect levels (NOAEL) of naringin were at least 1250 mg/kg/day for fertility and early embryonic development in rats.
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http://dx.doi.org/10.1016/j.yrtph.2021.104938DOI Listing
April 2021

Optimization and mechanism exploration for Escherichia coli transformed with plasmid pUC19 by the combination with ultrasound treatment and chemical method.

Ultrason Sonochem 2021 Jun 20;74:105552. Epub 2021 Apr 20.

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China. Electronic address:

As a basic technique of molecular cloning, bio-transformation has been successfully used in the fields of biomedicine and food processing. In this study, we established a transformation system of exogenous DNA into E. coli cells mediated by ultrasound. Under the optimal conditions (i.e. 35 °C, 40 W, 25 s, OD600 = 0.4-0.6) optimized by RSM, the transformation efficiency reached at 1.006 × 10 CFU/μg DNA. The results of membrane permeability, macromolecular substance and cell structure analysis before and after ultrasound treatment showed that the damage of host cells induced by lower (40 W) ultrasound and shorter ultrasound time (25 s) was reversible, and the transformation efficiency and cell survival rate were not significantly affected under this condition. In brief, proper changes in cell membrane and cell wall were the basic conditions for host cells to uptake exogenous DNA, while, whether exogenous DNA could be replicated and expressed in cells depends on the viability of host cells.
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http://dx.doi.org/10.1016/j.ultsonch.2021.105552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8091046PMC
June 2021

Correction: A lithium air battery with a lithiated Al-carbon anode.

Chem Commun (Camb) 2021 Apr 1;57(30):3724. Epub 2021 Apr 1.

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, Fudan University, Shanghai 200433, China.

Correction for 'A lithium air battery with a lithiated Al-carbon anode' by Ziyang Guo et al., Chem. Commun., 2015, 51, 676-678, DOI: .
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http://dx.doi.org/10.1039/d1cc90115jDOI Listing
April 2021

Molybdenum Carbide Buried in D-Shaped Fibers as a Novel Saturable Absorber Device for Ultrafast Photonics Applications.

ACS Appl Mater Interfaces 2021 Apr 13;13(16):19128-19137. Epub 2021 Apr 13.

State Key Laboratory of Transient Optics and Photonics, Xi'an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi'an 710119, China.

Study of nonlinear laser-matter interactions in 2D materials has promoted development of photonics applications. As a typical MXene material, molybdenum carbide (MoC) has attracted much attention because of its graphene-like structure. Here, a type of D-shaped fiber (DF)-buried MoC saturable absorber (SA) fabricated by magnetron-sputtering deposition (MSD) and sol-gel technique is reported. The MoC material was buried between the bottom DF and the upper amorphous silica fabricated by sol-gel technology. Therefore, the DF-based SA effectively solves the problem of material shedding and aging, thus improving the stability and damage threshold of the fiber laser. Application of the SA in erbium-doped fiber laser and stable passive Q-switched operation with a maximum pulse energy of 430.47 nJ is realized. By adjusting the polarization state and pump power, high-power mode-locked pulses are generated with a pulse duration and output power of 199 fs and 54.13 mW, respectively. Further, bound-state soliton pulses are obtained with a pulse width of 312 fs and soliton interval of 1.26 ps for the first time based on MXene materials. Moreover, by application of the SA in ytterbium-doped fiber lasers, a stable dissipative soliton mode-locked pulse is obtained with a pulse width of 23 ps. These results indicate that the DF-based buried MoC as a novel SA provides a reliable method for all-fiber and multifunctional high-power ultrafast laser.
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http://dx.doi.org/10.1021/acsami.1c01345DOI Listing
April 2021

Impacts of Pharmacists-Managed Oncology Outpatient Clinic on Resolving Drug-Related Problems in Ambulatory Neoplasm Patients: A Prospective Study in China.

Inquiry 2021 Jan-Dec;58:469580211009662

Department of Pharmacy, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Pharmacists are health care professionals who are actively involved in identifying and solving drug-related problems (DRPs) in neoplasm patients. However, the effectiveness of pharmaceutical services at outpatient clinic for neoplasm patients have not been reported in China. This study aims to describe and investigate the impacts of pharmacists-managed oncology outpatient clinic on ambulatory neoplasm patients. We performed a descriptive, prospective study from June 6, 2018 to June 6, 2020. Firstly, we established a pharmacists-managed oncology outpatient clinic and a Pharmacists Work System of Medication Therapy Management (MTM) software with the cooperation of oncologists, pharmacists and software engineers in 2018. Subjects were neoplasm patients who visited the pharmacists-managed outpatient clinic. The pharmacists performed a comprehensive assessment of the patient's medication and made planned interventions based on the DRPs identified. A total of 215 eligible patients with 707 visits were enrolled and recorded in the MTM software. A total of 316 DRPs (1.47 per patient) were identified. Adverse reactions, non-adherence, untreated indication, and drug interactions were the leading DRPs. 261 (82.6%) of the identified DRPs had been confirmed as resolved and 104 (78.2%) of adverse reactions were improved following pharmacist interventions and 2 to 3 course follow-up. Of the 382 planned interventions, 345 (90.3%) were accepted by patients or physicians. This is the first pharmacists-managed oncology outpatient clinic to describe the type of DRPs in neoplasm patients and evaluate the effectiveness of pharmacist interventions in China. Pharmacist interventions were efficacious in resolving DRPs and improving adverse reactions. We confirmed that pharmacists have an important role in ambulatory neoplasm patients care.
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http://dx.doi.org/10.1177/00469580211009662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047945PMC
April 2021

Agomelatine prevents macrophage infiltration and brain endothelial cell damage in a stroke mouse model.

Aging (Albany NY) 2021 04 4;13(10):13548-13559. Epub 2021 Apr 4.

Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

Background And Purpose: Ischemic/reperfusions are regarded as the clinical consensus for stroke treatment, which results in secondary injury of brain tissues. Increased blood-brain barrier (BBB) permeability and infiltration of inflammatory cells are responsible for the ischemic/reperfusion injury. In the present study, we aimed to investigate the effects of Agomelatine on brain ischemic/reperfusions injury and the underlying mechanism.

Methods: MCAO model was established in mice. The expressions of CD68 and claudin-5 in the cerebral cortex were determined using an immunofluorescence assay. Brain permeability was evaluated using Evans blue staining assay. A two-chamber and two-cell trans-well assay was used to detect the migration ability of macrophages through endothelial cells. The expression levels of claudin-5 and MCP-1 in the endothelial cells were determined using qRT-PCR and ELISA.

Results: CD68 was found to be up-regulated in the cerebral cortex of MCAO mice but was down-regulated by treatment with Agomelatine. The expression level of down-regulated claudin-5 in the cerebral cortex of MCAO mice was significantly suppressed by Agomelatine. Deeper staining of Evans blue was found in the MCAO group, which was however faded significantly in the Agomelatine treated MCAO mice. The migrated macrophages were significantly increased by hypoxia incubation but were greatly suppressed by the introduction of Agomelatine. The down-regulated claudin-5 by hypoxic incubation in endothelial cells was up-regulated by treatment with Agomelatine. Furthermore, the increased expression of MCP-1 in endothelial cells under hypoxic conditions was significantly inhibited by Agomelatine.

Conclusion: Agomelatine prevents macrophage infiltration and brain endothelial cell damage in a stroke mouse model.
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http://dx.doi.org/10.18632/aging.202836DOI Listing
April 2021

Impact of Secondary Aneurysmal Bone Cysts on Survival of Patients with Enneking Stage IIB Extremity Osteosarcoma: A Propensity Score Matching Analysis.

Ann Surg Oncol 2021 Apr 2. Epub 2021 Apr 2.

Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Background: The clinicopathology of aneurysmal bone cysts (ABCs) secondary to osteosarcoma has not yet been reported. We conduct a retrospective review of ABCs secondary to osteosarcoma to characterize clinicopathology and influence on the survival of patients with Enneking stage IIB extremity osteosarcoma.

Patients And Methods: A total of 300 patients with Enneking stage IIB extremity osteosarcoma were eligible for analysis. These cases were divided, according to the pathology of biopsy and magnetic resonance imaging (MRI), into ABCs group and no ABCs group. Patients (ABCs versus no ABCs) were compared using a 1:2 propensity score analysis to best match between groups. Clinicopathology and survival data were analyzed.

Results: The total occurrence rate of secondary ABCs was 10.3%. A higher prevalence of pathological fractures was observed in the ABCs group (22.6%) compared with the no ABCs group (8.6%) (p = 0.032). Patients with ABCs were more likely to undergo amputation compared with patients without ABCs (p = 0.007). Those with secondary ABCs had poorer response to chemotherapy before and after propensity score matching (p = 0.006 and p = 0.048, respectively). Kaplan-Meier survival analysis showed that EFS and OS distributions were not significantly different between the two patient groups. ABCs were not significantly different in terms of EFS or OS in the multivariate analysis model (p > 0.05).

Conclusions: The presence of secondary ABCs was associated with increased occurrence rate of pathological fracture and high percentage of amputation. Moreover, patients with secondary ABCs had poorer response to chemotherapy. However, the presence of secondary ABCs did not influence survival of patients with Enneking stage IIB extremity osteosarcoma.
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http://dx.doi.org/10.1245/s10434-021-09878-zDOI Listing
April 2021

CircPITX1 Regulates Proliferation, Angiogenesis, Migration, Invasion, and Cell Cycle of Human Glioblastoma Cells by Targeting miR-584-5p/KPNB1 Axis.

J Mol Neurosci 2021 Mar 24. Epub 2021 Mar 24.

Department of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.

Recent researches reported that several circular RNAs (circRNAs) were associated with the glioblastoma (GBM) progression, while the regulatory role of circPITX1 remains unknown in GBM. The real-time quantitative polymerase chain reaction (RT-qPCR) was used to quantify circPITX1, miR-584-5p, and karyopherin b1 (KPNB1) expression in GBM tissues and cells. The proliferation capability of cells was analyzed by Cell Counting Kit-8 (CCK-8) and colony-forming assays. The matrigel angiogenesis assay was used to assess tube formation in GBM cells. Flow cytometry assays were conducted to evaluate the cell cycle distribution of GBM cells. The migration and invasion assays were assessed by transwell assay. The Western blot assay was employed to quantify the protein expression level in GBM tissues and cells. The targets of circPITX1 and miR-584-5p were confirmed by dual-luciferase reporter and RNA pull-down assays. A xenograft experiment in nude mice was used to assess the functional role of circPITX1 in vivo. CircPITX1 was obviously overexpressed in GBM tissues and cells when compared with negative groups. The functional experiment implied that knockdown of circPITX1 suppressed proliferation, angiogenesis, migration, invasion, and tumor growth in vivo along with induced cell cycle arrest of GBM cells. Furthermore, miR-584-5p was a target gene of circPITX1, and knockdown of miR-584-5p could abolish circPITX1 silencing-induced effects on GBM cells. KPNB1 was a target gene of miR-584-5p, and functional experiments revealed that overexpression of miR-584-5p repressed proliferation, angiogenesis, migration, invasion, and cell cycle process in GBM cells by targeting KPNB1. Mechanistically, circPITX1/miR-584-5p/KPNB1 axis regulated GBM process via mediating proliferation, angiogenesis, migration, invasion, and cell cycle process of GBM cells.
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http://dx.doi.org/10.1007/s12031-021-01820-yDOI Listing
March 2021

Postoperative Long-Term Independence Among the Elderly With Meningiomas: Function Evolution, Determinant Identification, and Prediction Model Development.

Front Oncol 2021 5;11:639259. Epub 2021 Mar 5.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Maintenance of postoperative long-term independence has value for older adults who undergo surgical procedures. However, independence has barely caught attention for the elderly with meningiomas. Preventing postoperative long-term independence decline in this population necessitates the identification of the factors related to this outcome and minimizing their implications. Therefore, we assessed the independence evolution and identified potential determinants and population.

Materials And Methods: From 2010 to 2016, elderly meningioma patients (≥65 years old) undergoing operation at Beijing Tiantan Hospital were included in our study. The primary outcome was 3-year (., long-term) postoperative independence measured by Karnofsky performance scale (KPS) score. We used univariate and multivariate analyses to determine the risk factors for postoperative long-term independence, and nomogram was established.

Results: A total of 470 patients were included eligibly. The distribution in each KPS was significantly different before and 3 years after resection ( < 0.001). Especially in patients with preoperative KPS 80 and 70, only 17.5 and 17.3% of the patients kept the same KPS after 3 years, and the remaining patients experienced significant polarization. The most common remaining symptom cluster correlated with postoperative long-term independence included fatigue (R = -0.795), memory impairment (R = -0.512), motor dysfunction (R = -0.636) and communication deficits (R = -0.501). Independent risk factors for postoperative long-term non-independence included: advanced age (70-74 65-69 OR: 2.631; 95% CI: 1.545-4.481 and ≥75 65-69 OR: 3.833; 95% CI: 1.667-8.812), recurrent meningioma (OR: 7.791; 95% CI: 3.202-18.954), location in the skull base (OR: 2.683; 95% CI: 1.383-5.205), tumor maximal diameter >6 cm (OR: 3.089; 95% CI: 1.471-6.488), nerves involved (OR: 3.144; 95% CI: 1.585-6.235), high risk of WHO grade and biological behavior (OR: 2.294; 95% CI: 1.193-4.408), recurrence during follow-up (OR: 10.296; 95% CI: 3.253-32.585), lower preoperative KPS (OR: 0.964; 95% CI: 0.938-0.991) and decreased KPS on discharge (OR: 0.967; 95% CI: 0.951-0.984) ( < 0.05). The discrimination and calibration of the nomogram revealed good predictive ability (C-index: 0.810).

Conclusion: Elderly meningioma patients might present significant polarization trend in maintaining long-term independence after surgery. Our findings will be helpful for guiding surgical management for the elderly with meningioma and provide proposals for early functional rehabilitation.
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http://dx.doi.org/10.3389/fonc.2021.639259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7982808PMC
March 2021

Ventricular fibrillation storm after revascularization of chronic total occlusion of the left anterior descending artery: is this reperfusion arrhythmia?

J Int Med Res 2021 Mar;49(3):300060521997618

Department of Cardiology, the First Hospital of Jilin University, Changchun, Jilin Province, China.

Electrical storm is a life-threatening emergency condition defined as three or more episodes of ventricular tachycardia or ventricular fibrillation (VF) within 24 hours requiring anti-tachycardia therapy, electrical cardioversion, or defibrillation. However, studies of the incidence of electrical storm after chronic total occlusion-percutaneous coronary intervention (CTO-PCI) are limited, and post-procedural VF after revascularization of CTO has not been described. The purpose of this article was to present a case of post-operative VF electrical storm after revascularization of CTO of the left anterior descending (LAD) artery to determine whether the electrical storm was caused by reperfusion arrhythmia or compromise of either branch vessels or the collateral circulation during intervention.
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http://dx.doi.org/10.1177/0300060521997618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8166392PMC
March 2021

The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells.

Int J Mol Sci 2021 Feb 25;22(5). Epub 2021 Feb 25.

Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-Evaluation of Post-Marketed TCM, Guangdong Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.

Naringenin, a natural flavonoid widely found in citrus fruits, has been reported to possess anti-oxidant, anti-inflammatory, and hepatoprotective properties as a natural dietary supplement. However, the regulatory mechanism of naringenin in human liver remains unclear. In the present study, messenger RNA sequencing (mRNA-seq), microRNA sequencing (miRNA-seq), and real-time qPCR were used to distinguish the expression differences between control and naringenin-treated HepaRG cells. We obtained 1037 differentially expressed mRNAs and 234 miRNAs. According to the target prediction and integration analysis in silico, we found 20 potential miRNA-mRNA pairs involved in liver metabolism. This study is the first to provide a perspective of miRNA-mRNA interactions in the regulation of naringenin via an integrated analysis of mRNA-seq and miRNA-seq in HepaRG cells, which further characterizes the nutraceutical value of naringenin as a food additive.
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http://dx.doi.org/10.3390/ijms22052292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7956767PMC
February 2021

Structural characteristics of polysaccharide microcapsules from, and their applications in skin wound healing and pathological repair.

Biomed Mater 2021 Feb 24. Epub 2021 Feb 24.

Lanzhou University of Technology, School of Life Science and Engineering, Lanzhou University of Technology, Langongping Road 287, Qilihe District, Lanzhou City, Gansu Province, P. R. China, Lanzhou, Gansu, 730050, CHINA.

In this study, the extraction conditions of Nostoc commune Vauch polysaccharide (NCVP) were optimized by single factor and orthogonal experiments. Then, the microcapsules (NCVPM) was prepared. After analyzing the microcapsule structural, thermal characteristics, the skin wound healing ability was studied by establishing back trauma rat models. Results showed that, the NCVP yield was 10.37% under the following optimum conditions: 210 minute extraction time, solid-liquid ratio of 1:50 and extraction temperature of 90°C. The overall performance of the microcapsule was the best when the concentration of sodium alginate, calcium chloride and chitosan was 2%, 3% and 0.3%, respectively. NCVPM had spherical morphology, typical microcapsule structural characteristics and good thermal stability, and NCVP was dispersed in the microcapsules. NCVPM showed good biocompatibility and biodegradability, which met the requirements for slow-release polymer materials. After 14 days treatment, the wound healing rate was 92.4%, the cells were arranged neatly and regularly, the cell nucleus became large and elliptical, and the cell has a tendency to divide, the fibers and microvessel were significantly more. By evaluating mechanism, NVCPM could increase the contents of hydroxyproline (HYP) and glutathione (GSH-Px) to protect cells from oxidative damage, leading in turn to accelerate wound healing and shorted wound healing times. And could accelerate cell division, collagen and microvascular production by increasing transcription levels of Vascular endothelial growth factor (VEGF) mRNA and miRNA-21.
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http://dx.doi.org/10.1088/1748-605X/abe978DOI Listing
February 2021

Preparation, characterization and wound healing effect of alginate/chitosan microcapsules loaded with polysaccharides from Nostoc Commune Vaucher.

Biomed Mater 2021 Feb 18;16(2):025015. Epub 2021 Feb 18.

School of Life Science and Engineering, Lanzhou University of Technology, Langongping Road 287, Qilihe District, Lanzhou, Gansu Province 730000, People's Republic of China.

Biologically active coating materials could promote the growth of granulation tissue as auxiliary materials, while natural polysaccharides could promote vascular regeneration and wound healing. Therefore, in this study, ultrasound-assisted extract of Nostoc commune Vaucher polysaccharides (UAP) yield after the process optimization was 12.89 ± 0.24%, which was used to prepare microcapsules by emulsification and cross-linking. The effect of alginate/chitosan-UAP composite materials on wound healing in an experimental rat model for 14 d and its physical properties were evaluated. In vitro experiments indicated that the UAP microcapsule material had a porous and loose three-dimensional network structure, and had good biocompatibility and swelling properties as a wound healing material. Animal experiments indicated that UAP microcapsules could extremely significantly promote wound healing (P < 0.01), and wound closure rate reached 79.16 ± 3.91% on 14th day. Meanwhile UAP microcapsules might promote angiogenesis and granulation growth by enhancing immunity and increasing the expression of VEGF and miR-21. Therefore, the composites of UAP microcapsules have shown encouraging results as a potential dressing for wound healing.
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http://dx.doi.org/10.1088/1748-605X/abd051DOI Listing
February 2021

Towards High-Performance Zinc-Based Hybrid Supercapacitors via Macropores-Based Charge Storage in Organic Electrolytes.

Angew Chem Int Ed Engl 2021 Apr 17;60(17):9610-9617. Epub 2021 Mar 17.

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai, 200433, China.

Zn-based aqueous supercapacitors are attracting extensive attention. However, most of the reported long-life and high-power performances are achieved with low Zn-utilization (<0.6 %) and low mass loading in cathode (<2 mg cm ). And, many obtained high energy densities are generally evaluated without considering the mass of Zn-anode. Herein, we propose a Zn-based hybrid supercapacitor, involving a metal organic framework derived porous carbon cathode, a Zn-anode and an N, N-dimethylformamide (DMF)-based electrolyte containing Zn . We demonstrate that the charge storage of cathode mainly occurs in macropores, showing high rate performance at high mass loading (40 mg cm ). Furthermore, the aprotic nature of electrolyte and formation of Zn -DMF complex avoid the Zn-corrosion and dendrite formation. Therefore, the supercapacitor shows a long-life (9,000 cycles) with a high Zn-utilization (2.2 %). When calculated with the total mass of cathode (40 mg cm ) and Zn-anode, the energy density reaches 25.9 Wh kg .
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http://dx.doi.org/10.1002/anie.202014766DOI Listing
April 2021

NaBi(IO): An Alkali-Metal Bismuth Iodate with Intriguing One-Dimensional [BiIO] Chains and Pressure-Induced Structural Transition.

Inorg Chem 2021 Mar 11;60(5):2893-2898. Epub 2021 Feb 11.

Beijing Center for Crystal Research and Development, Key Laboratory of Functional Crystals and Laser Technology, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

An alkali-metal bismuth iodate, NaBi(IO), was successfully obtained by the hydrothermal method for the first time and contains intriguing one-dimensional [BiIO] chains. High-pressure Raman spectra were carried out to investigate the structural transition of NaBi(IO). Electronic states and anisotropic optical responses were also investigated by theoretical calculations.
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http://dx.doi.org/10.1021/acs.inorgchem.0c03697DOI Listing
March 2021

Single-segment central lumbar spinal stenosis: Correlation with lumbar X-ray measurements.

J Back Musculoskelet Rehabil 2021 Jan 29. Epub 2021 Jan 29.

Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Background: Lumbar X-rays are usually preferred in patients with lower back pain, but lumbar spinal stenosis (LSS) cannot be directly observed on lumbar X-ray films.

Objective: The purpose of this study is to explore the correlation between the degree of single-segment central LSS and lumbar X-ray measurements.

Methods: The data of 60 male patients aged 39-78 years with single-segment central LSS were analyzed. Linear correlation analysis was used to determine the correlation between the single-segment central LSS and the various measurement parameters. Multiple linear regression analysis was used to analyze the factors affecting single-segment central LSS.

Results: There were significant differences in S1/S0, E, B, L1-5Cobb, and M among the three groups (p< 0.05). S1/S0 was positively correlated with E, B, L1-5Cobb, and M (p< 0.05), but was not correlated with D (p= 0.66). After multiple linear regression analysis, B, L1-5Cobb, and M were independently associated with S1/S0.

Conclusions: The B, L1-5Cobb, and M parameters were independently associated with single-stage central LSS, and would likely be of particular value in evaluating the degree of single-segment central LSS; B, L1-5Cobb, and M served as independent predictors of the degree of LSS. These findings will guide clinicians' decision-making in the future.
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http://dx.doi.org/10.3233/BMR-200051DOI Listing
January 2021

Association of ABO blood groups with ovarian reserve, and outcomes after assisted reproductive technology: systematic review and meta-analyses.

Reprod Biol Endocrinol 2021 Feb 6;19(1):20. Epub 2021 Feb 6.

Reproductive Medicine Center, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha City, Hunan Province, People's Republic of China.

Background: There has been an interest in the relationship between ABO blood groups and infertility. Many studies have investigated the association of ABO blood groups with diminished ovarian reserve (DOR), ovarian hyperstimulation syndrome (OHSS), and outcomes of assisted reproductive technology (ART), with controversial results.

Methods: A systematic review and meta-analysis was conducted to evaluating the association of ABO blood groups with DOR, OHSS, and outcomes of ART.

Results: Thirteen studies performed between 2010 and 2018 were included in this meta-analysis. DOR, OHSS, live birth rate (LBR), clinical pregnancy rate (CPR), miscarriage rate (MR) were reported in 9, 2, 4, 3, 2 studies, respectively. The combined results showed similar risk of DOR among individuals with blood group A (RR, 0.98; 95% confidence interval [CI], 0.85, 1.13), B (RR, 0.96; 95% CI, 0.76, 1.20), AB (RR, 1.00; 95% CI, 0.76, 1.30), and non-O (RR, 0.94; 95% CI, 0.79, 1.11) as compared to those with blood group O. Meta-analysis showed that the incidences of OHSS were similar in women with blood group A (RR, 1.05; 95% CI, 0.66, 1.66), B (RR, 1.04; 95% CI, 0.46, 2.35), AB (RR, 0.51; 95% CI, 0.10, 2.56), non-O (RR, 1.02; 95% CI, 0.65, 1.57) with blood group O. As to the clinical outcomes, meta-analysis showed no difference in LBR among individuals with blood group A (RR, 1.27; 95% CI, 0.74, 2.17), B (RR, 1.47; 95% CI, 0.95, 2.29), AB (RR, 1.48; 95% CI, 0.76, 2.90), non-O (RR, 1.28; 95% CI, 0.83, 1.98) when compared to those with blood group O. Similarly, the results also found that there were no difference in CPR and MR between women with blood A (CPR: RR, 1.12), B (CPR: RR, 1.08), AB (CPR: RR, 1.05), non-O (CPR: RR, 1.05; MR: RR, 0.94) and blood group O.

Conclusions: ABO blood groups may not be associated with DOR, OHSS, LBR, CPR, and MR of ART. Infertility and ART outcomes are influenced by multiple factors. Blood groups should not be taken into account excessively during diagnosis and treatment of infertile women.
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http://dx.doi.org/10.1186/s12958-020-00685-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866457PMC
February 2021

Mechanism-of-Action Elucidation of Reversible Li-CO Batteries Using the Water-in-Salt Electrolyte.

ACS Appl Mater Interfaces 2021 Feb 5;13(6):7396-7404. Epub 2021 Feb 5.

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, China.

Li-CO batteries have attracted worldwide attention because of their dual characteristics of high energy density and effective CO capture. However, the basic electrochemistry mechanism involved has been unclear, which is mainly confused by the complicated decomposition of organic electrolytes. Herein, water-in-salt (WIS, LiTFSI/HO 21.0 mol/1 kg) has been explored as a suitable electrolyte for the first time to investigate the reaction mechanism of Li-CO batteries with different cathodes (carbon nanotube (CNT) and MoC/CNT, respectively). An MoC-based Li-CO battery with WIS delivers a higher energy efficiency of 83% and a superior cyclability, compared to those of the CNT-based counterpart cell. Through various ex/in situ qualitative/quantitative characterizations, the MoC-based Li-CO battery with WIS can operate on the reversible conversion of CO-to-LiCO ((e/CO) = 1) at lower discharge/charge overpotentials, while the CNT-based counterpart cell is based on the formation/decomposition of LiCO ((e/CO) ≈ 1.33) at high overpotentials. Such a difference in CO reduction products stems from the stronger interaction between MoC(101) and LiCO than that of the CNT and LiCO based on the density functional theory calculations, resulting in the selective stabilization of the intermediate product LiCO on the MoC surface.
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http://dx.doi.org/10.1021/acsami.1c01306DOI Listing
February 2021

The Effect of Hydrothermal Treatment on Structure and Flotation Characteristics of Lignite and a Mechanistic Analysis.

ACS Omega 2021 Jan 12;6(3):1930-1940. Epub 2021 Jan 12.

School of Chemical and Environmental Engineering, China University of Mining & Technology (Beijing), Beijing 100083, China.

Lignite is difficult to obtain highly efficient indexes by conventional flotation due to its poor surface hydrophobicity. Although the modification of flotation reagents has made some progress in improving the flotation performance, they all remain at the stage in the laboratory. Here, we proposed to improve the flotation performance by hydrothermal treatment dewatering (HTD) for lignite. Combined with the C NMR and FT-IR analysis, the impact of the HTD process on lignite's chemical structural evolution and flotation performance was investigated. The results showed that the HTD process is an effective means for dehydration and deoxygenation to increase lignite quality and the metamorphic degree of coal. The content of oxygen-containing functional groups generally decreases during the HTD process, especially carboxyl acid and ether groups. Therefore, surface properties and wettability of HTD coal samples were changed, and the contact angle gradually increases with the HTD temperature increased, which enhance the hydrophobicity and decrease hydrophilia of the lignite surface. The HTD process effectively improves the flotation performance of lignite during the conventional flotation operation condition, even if the coal pulp after HTD was directly used as a flotation feedstock. Specifically, the coal oil and capryl alcohol were used as collector and forming agents, respectively, and the pulp concentration was adjusted to 60 g/L. The yield of the cleaned coal increased from 12.14% of the raw coal to 55.58% of HTD310, and combustible matter recovery increased from 13.83% of the raw coal to 65.17% of HTD310 by raw coal basis.
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http://dx.doi.org/10.1021/acsomega.0c04713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841791PMC
January 2021

Temperature and pH Dual Responsive Nanogels of Modified Sodium Alginate and NIPAM for Berberine Loading and Release.

ACS Omega 2021 Jan 4;6(2):1119-1128. Epub 2021 Jan 4.

Laboratory and Equipment Management, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.

pH- and temperature-sensitive nanogels (NGs) were prepared from sodium alginate (SA) and -isopropylacrylamide (NIPAM), as the sensitivity at pH 5.5 and 31 °C. SA was pH-modified with glutamic acid (Glu) and ethylenediamine (EDA). The products Glu-SA (Glu-modified SA) and EGSA (EDA- and Glu-modified SA) were characterized by ninhydrin color reaction, infrared spectroscopy, and zeta potential, and the best reactant ratio was selected. Moreover, temperature-sensitive, pH-sensitive EGSA-NGs possessing a semi-interpenetrating network structure were prepared by radical polymerization using -isopropylacrylamide. The morphology of EGSA-NGs was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic force microscopy (AFM). The cytotoxicity test shows the low cytotoxicity and high biocompatibility of the NGs. The newly prepared NGs were also subjected to pH-sensitive temperature-sensitive in vitro drug-loading and drug-release experiments. The pH-sensitive and temperature-sensitive experiments showed that the particle size of EGSA-NGs was reduced at pH 5.5 and above 31 °C. The drug-loading and drug-release experiments also confirmed this finding, indicating that the newly synthesized NGs could release the drug according to the environmental changes. Therefore, the material has potential application value in solid tumor targeted therapy.
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http://dx.doi.org/10.1021/acsomega.0c03965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7818125PMC
January 2021

Omics resources and omics-enabled approaches for achieving high productivity and improved quality in pea (Pisum sativum L.).

Theor Appl Genet 2021 Mar 12;134(3):755-776. Epub 2021 Jan 12.

College of Life Sciences, China Jiliang University, Hangzhou, 310018, China.

Pea (Pisum sativum L.), a cool-season legume crop grown in more than 85 countries, is the second most important grain legume and one of the major green vegetables in the world. While pea was historically studied as the genetic model leading to the discovery of the laws of genetics, pea research has lagged behind that of other major legumes in the genomics era, due to its large and complex genome. The evolving climate change and growing population have posed grand challenges to the objective of feeding the world, making it essential to invest research efforts to develop multi-omics resources and advanced breeding tools to support fast and continuous development of improved pea varieties. Recently, the pea researchers have achieved key milestones in omics and molecular breeding. The present review provides an overview of the recent important progress including the development of genetic resource databases, high-throughput genotyping assays, reference genome, genes/QTLs responsible for important traits, transcriptomic, proteomic, and phenomic atlases of various tissues under different conditions. These multi-faceted resources have enabled the successful implementation of various markers for monitoring early-generation populations as in marker-assisted backcrossing breeding programs. The emerging new breeding approaches such as CRISPR, speed breeding, and genomic selection are starting to change the paradigm of pea breeding. Collectively, the rich omics resources and omics-enable breeding approaches will enhance genetic gain in pea breeding and accelerate the release of novel pea varieties to meet the elevating demands on productivity and quality.
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http://dx.doi.org/10.1007/s00122-020-03751-5DOI Listing
March 2021

Tricolor Ho^{3+} Photoluminescence Enhancement from Site Symmetry Breakdown in Pyrochlore Ho_{2}Sn_{2}O_{7} after Pressure Treatment.

Phys Rev Lett 2020 Dec;125(24):245701

Center for High Pressure Science and Technology Advanced Research (HPSTAR), Shanghai 201203, China.

The photoluminescence (PL) characterization spectrum has been widely used to study the electronic energy levels. Ho^{3+} is one of the commonly used doping elements to provide the PL with concentration limited to 1% atomic ratio. Here, we present a tricolor PL achieved in pyrochlore Ho_{2}Sn_{2}O_{7} through pressure treatment at room temperature, which makes a non-PL material to a strong multiband PL material with Ho^{3+} at the regular lattice site with 18.2% concentration. Under a high pressure compression-decompression treatment up to 78.0 GPa, the Ho_{2}Sn_{2}O_{7} undergoes pyrochlore (Fd 3m), to cotunnite (Pnma), then amorphous phase transition with different Ho^{3+} coordinations and site symmetries. The PL emerged from 31.2 GPa when the pyrochlore to cotunnite phase transition took place with the breakdown of site symmetry and enhanced hybridization of Ho^{3+} 4f and 5d orbitals. Upon decompression, the materials became an amorphous state with a partial retaining of the defected cotunnite phase, accompanied with a large enhancement of red-dominant tricolor PL from the ion pair cross-relaxation effect in the low-symmetry (C_{1}) site, in which two distinct Ho^{3+} emission centers (S center and L center) are present.
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http://dx.doi.org/10.1103/PhysRevLett.125.245701DOI Listing
December 2020