Publications by authors named "Yonggang Wang"

524 Publications

Naringenin suppresses BEAS-2B-derived extracellular vesicular cargoes disorder caused by cigarette smoke extract thereby inhibiting M1 macrophage polarization.

Front Immunol 2022 18;13:930476. Epub 2022 Jul 18.

Guangdong Engineering and Technology Research Center for Quality and Efficacy Re-evaluation of Post-marketed Traditional Chinese Medicine (TCM), State Key Laboratory of Biocontrol, Guangdong Provincial Key Laboratory of Plant Resources, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Extracellular vesicles (EVs)-mediated epithelium-macrophage crosstalk has been proved to maintain lung homeostasis in cigarette smoke-induced lung diseases such as chronic obstructive pulmonary disease (COPD). In our previous study, we found that EVs derived from cigarette smoke extract (CSE) treated BEAS-2B promoted M1 macrophage polarization, which probably accelerated the development of inflammatory responses. Naringenin has been proved to suppress M1 macrophage polarization, but whether naringenin regulates macrophage polarization mediated by EVs has not been reported. In this study, we firstly found that EVs derived from naringenin and CSE co-treated BEAS-2B significantly inhibited the expression of CD86 and CD80 and the secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, inducible nitric oxide synthase (iNOS), and IL-12 in macrophage induced by EVs derived from CSE-treated BEAS-2B. Further research revealed that naringenin downregulated BEAS-2B-derived EVs miR-21-3p which targeted phosphatase and tensin homolog deleted on chromosome ten/protein kinase B (PTEN/AKT) cascade in macrophages and then suppressed M1 macrophage polarization. Subsequent proteomics suggested that naringenin decreased BEAS-2B-derived EVs poly ADP-ribose polymerase (PARP)1 expression thereby suppressing M1 macrophage polarization probably. Our study provides novel pharmacological references for the mechanism of naringenin in the treatment of cigarette smoke-induced lung inflammatory diseases.
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http://dx.doi.org/10.3389/fimmu.2022.930476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9342665PMC
August 2022

Facilitating Low-Temperature Li Storage via a Riemannian Surface.

ACS Cent Sci 2022 Jul 8;8(7):868-870. Epub 2022 Jul 8.

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai 200433, China.

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http://dx.doi.org/10.1021/acscentsci.2c00641DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335910PMC
July 2022

XIST sponges miR-320d to promote chordoma progression by regulating ARF6.

J Bone Oncol 2022 Aug 16;35:100447. Epub 2022 Jul 16.

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.

Background: Long non-coding RNAs (lncRNAs) have been demonstrated to play important roles in various tumors, including chordoma. The purpose of this study was to investigate the role and mechanism of lncRNA X-inactive specific transcript (XIST) in chordoma.

Methods: RNA levels and protein levels were measured by real-time quantitative polymerase chain reaction (RT‑qPCR) and western blot assay, respectively. Cell proliferation was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 5-ethynyl-2'-deoxyuridine (EdU) assay and colony formation assay. Tanswell assay was used to examine cell migration and invasion. Cellular glycolysis was examined via the measurement of extracellular acidification rate (ECAR) and lactate production. The interaction between microRNA-320d (miR-320d) and XIST or ADP-ribosylation factor 6 (ARF6) was predicted by bioinformatics analysis and verified by a dual-luciferase reporter and RNA-pull down assays. The xenograft tumor model was used to explore the biological function of XIST .

Results: XIST was overexpressed in chordoma tissues. XIST knockdown suppressed chordoma cell proliferation, migration, invasion, and glycolysis. XIST acted as a sponge of miR-320d. Moreover, miR-320d overexpression inhibited the proliferation, migration, invasion, and glycolysis of chordoma cells. ARF6 was a direct target of miR-320d, and XIST upregulated ARF6 expression via sponging miR-320d. Furthermore, overexpression of ARF6 reversed the inhibitory effects of XIST knockdown on chordoma cell proliferation, migration, invasion, and glycolysis. Importantly, XIST silencing blocked xenograft tumor growth .

Conclusion: XIST knockdown inhibited chordoma progression via regulating the miR-320d/ARF6 axis, providing a novel insight into chordoma pathogenesis.
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http://dx.doi.org/10.1016/j.jbo.2022.100447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9309415PMC
August 2022

Interfacially confined preparation of fumaronitrile-based nanofilms exhibiting broadband saturable absorption properties.

J Colloid Interface Sci 2022 Jul 16;627:569-577. Epub 2022 Jul 16.

Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, PR China. Electronic address:

Interfacial nanofilms with nonlinear optical (NLO) properties were prepared via confined dynamic condensation of 4,4'-methylenedianiline (MDA) with the synthesized 2,3-bis(4-(bis(4-formylphenyl)amino)phenyl)fumaronitrile (BTFA). Investigated using the open-aperture Z-scan technique, BTFA showed reverse saturable absorption ascribed to the synergetic mechanisms of two-photon and excited-state absorption. In contrast, the as-prepared nanofilms demonstrated broadband saturable absorption within the spectral range of 720∼1700 nm. The characteristics of nonlinear absorption coefficient (β) decreased along with increasing the incident pulse intensity. Taking advantage of the flexibility and post-machinability properties, the folding layers of the nanofilms offered the feasibility to fine-tune the specific NLO responses. The optimal β value was found to be -10.1 cm/MW for eight-layer nanofilm as well as the normalized transmittance increased up to 35-fold at 800 nm. Utilized as a conceptual saturable absorber, the representative modulation depth and saturation intensity were observed to be around 2.4% and 7.37 GW/cm at 800 nm, respectively, comparable to traditional two-dimensional (2D) materials. Aiming to clarify the possible underlying physical processes, a four-level model was employed to illustrate the fast relaxation of the excited states. Present work demonstrates that proper design of building blocks combined with interfacially confined dynamic condensation enables rational development of high-performance NLO materials.
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http://dx.doi.org/10.1016/j.jcis.2022.07.083DOI Listing
July 2022

Pressure-Induced Structural Phase Transition, Anomalous Insulator-to-Metal Transition, and n-p Conduction-Type Switching in Defective, NiAs-Type CrTe.

Inorg Chem 2022 Aug 20;61(30):11923-11931. Epub 2022 Jul 20.

Center for High Pressure Science and Technology Advanced Research (HPSTAR), Beijing 100193, China.

CrTe, as a unique series of defective compounds with a NiAs-type structure and periodic metal vacancies, has attracted intensive research interest because of its diversity in structure and property dependent on the tunable stoichiometric ratio. Another feature of these compounds is their ability to switch between NiAs- and MnP-type structures, in which there often exist composition-, temperature-, or pressure-induced phase transitions accompanied by intriguing physical property switching. Herein, we report the syntheses of a series of CrTe compounds with similar compositions but distinct crystal structures, their phase transitions, anomalous transport, and photoelectric conduction behaviors under high pressure (HP). For the three CrTe compounds with δ = 0, 0.25, 0.375, CrTe undergoes pressure-induced NiAs-to-MnP phase transition at around 15 GPa, while CrTe and CrTe undergo isostructural phase transitions at around 12 and 11 GPa, respectively. Electrical transport measurements indicate anomalous conduction behaviors: CrTe undergoes a semiconductor-to-metal transition at around 24 GPa, while CrTe and CrTe show unexpected metal-semiconductor-metal transitions sequentially upon compression. Besides, CrTe and CrTe exhibit pressure-induced n-p conduction-type switching at around 9 and 3 GPa, respectively, while CrTe shows p-type conductivity in the full pressure range. Local structure analyses based on in situ HP Raman spectra are performed to understand the structure and property evolutions of CrTe under HP. Defective transition-metal chalcogenides with pressure-induced NiAs-to-MnP phase transition and conduction-type conversion provide a potential platform for the rational design of photoelectric conversion devices.
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http://dx.doi.org/10.1021/acs.inorgchem.2c01659DOI Listing
August 2022

An optimized microplate-based method to evaluate complement-dependent hemolysis mediated by intravenous immunoglobulins (IVIG).

Biologicals 2022 Jul 13. Epub 2022 Jul 13.

Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA. Electronic address:

Hemolytic reactions can cause serious complications after administration of Intravenous Immunoglobulin (IVIG), due to passive transfer of anti-A and anti-B IgG antibodies (isoagglutinins). A maximum allowable amount of isoagglutinins is established in the US and EU for licensed IVIG, as measured by a specified direct hemagglutination test (DHAT). Despite this limit, reports of hemolysis have increased over time, raising the question of how well the DHAT predicts clinically significant hemolysis. This study was undertaken to develop a microplate-based complement-dependent hemolysis assay (CDHA) that reproducibly measures functional hemolytic activity of IVIG, for assessment of IVIG products. An IVIG working reference reagent (NIBSC 14/160) was qualified as an assay control and for quantitation purposes. Hemolytic activities of 36 IVIG product lots encompassing seven brands and including 6 clinically hemolytic lots were measured. Hemolytic activity varied among IVIG product brands, and to a lesser extent, from lot-to-lot for individual brands. Correlation between the CDHA and DHAT was not robust which may reflect imprecision of the DHAT method or additional variables that influence complement-dependent hemolysis after opsonization. In conclusion, the CDHA provides a simple, specific, and sensitive tool for IVIG product characterization and investigation of hemolytic events by manufacturers, researchers, and regulatory authorities.
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http://dx.doi.org/10.1016/j.biologicals.2022.06.005DOI Listing
July 2022

Gamma-aminobutyric acid and glutamate/glutamine levels in the dentate nucleus and periaqueductal gray with episodic and chronic migraine: a proton magnetic resonance spectroscopy study.

J Headache Pain 2022 Jul 15;23(1):83. Epub 2022 Jul 15.

Headache Center, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China.

Background: The pathogenesis of migraine chronification remains unclear. Functional and structural magnetic resonance imaging studies have shown impaired functional and structural alterations in the brains of patients with chronic migraine. The cerebellum and periaqueductal gray (PAG) play pivotal roles in the neural circuits of pain conduction and analgesia in migraine. However, few neurotransmitter metabolism studies of these migraine-associated regions have been performed. To explore the pathogenesis of migraine chronification, we measured gamma-aminobutyric acid (GABA) and glutamate/glutamine (Glx) levels in the dentate nucleus (DN) and PAG of patients with episodic and chronic migraine and healthy subjects.

Methods: Using the MEGA-PRESS sequence and a 3-Tesla magnetic resonance scanner (Signa Premier; GE Healthcare, Chicago, IL, USA), we obtained DN and PAG metabolite concentrations from patients with episodic migraine (n = 25), those with chronic migraine (n = 24), and age-matched and sex-matched healthy subjects (n = 16). Patients with chronic migraine were further divided into those with (n = 12) and without (n = 12) medication overuse headache. All scans were performed at the Beijing Tiantan Hospital, Capital Medical University.

Results: We found that patients with chronic migraine had significantly lower levels of GABA/water (p = 0.011) and GABA/creatine (Cr) (p = 0.026) in the DN and higher levels of Glx/water (p = 0.049) in the PAG than healthy controls. In all patients with migraine, higher GABA levels in the PAG were significantly associated with poorer sleep quality (GABA/water: r = 0.515, p = 0.017, n = 21; GABA/Cr: r = 0.522, p = 0.015, n = 21). Additionally, a lower Glx/Cr ratio in the DN may be associated with more severe migraine disability (r = -0.425, p = 0.055, n = 20), and lower GABA/water (r = -0.424, p = 0.062, n = 20) and Glx/Water (r = -0.452, p = 0.045, n = 20) may be associated with poorer sleep quality.

Conclusions: Neurochemical levels in the DN and PAG may provide evidence of the pathological mechanisms of migraine chronification. Correlations between migraine characteristics and neurochemical levels revealed the pathological mechanisms of the relevant characteristics.
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http://dx.doi.org/10.1186/s10194-022-01452-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9287958PMC
July 2022

Synergy of Weakly-Solvated Electrolyte and Optimized Interphase Enables Graphite Anode Charge at Low Temperature.

Angew Chem Int Ed Engl 2022 Jul 14:e202208345. Epub 2022 Jul 14.

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, iChEM (Collaborative Innovation Center of Chemistry for Energy Materials), Fudan University, Shanghai, 200433, China.

Graphite anode suffers from great capacity loss and even fails to charge (i.e. Li -intercalation) under low temperature, mainly arising from the large overpotential including sluggish de-solvation process and insufficient ions movement in the solid electrolyte interphase (SEI). Herein, an electrolyte is developed by utilizing weakly solvated molecule ethyl trifluoroacetate and film-forming fluoroethylene carbonate to achieve smooth de-solvation and high ionic conductivity at low temperature. Evolution of SEI formed at different temperatures is further investigated to propose an effective room-temperature SEI formation strategy for low-temperature operations. The synergetic effect of tamed electrolyte and optimized SEI enables graphite with a reversible charge/discharge capacity of 183 mAh g at -30 °C and fast-charging up to 6C-rate at room temperature. Moreover, graphite||LiFePO full cell maintains a capacity retention of 78 % at -30 °C, and 37 % even at a super-low temperature of -60 °C. This work offers a progressive insight towards fast-charging and low-temperature batteries.
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http://dx.doi.org/10.1002/anie.202208345DOI Listing
July 2022

Correction: TRIM6 promotes colorectal cancer cells proliferation and response to thiostrepton by TIS21/FoxM1.

J Exp Clin Cancer Res 2022 Jul 13;41(1):221. Epub 2022 Jul 13.

Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

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http://dx.doi.org/10.1186/s13046-022-02434-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281032PMC
July 2022

Case Report: Osmotic Demyelination Syndrome After Transcatheter Aortic Valve Replacement: Case Report and Review of Current Literature.

Front Med (Lausanne) 2022 20;9:915981. Epub 2022 Jun 20.

Department of Critical Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Osmotic demyelination syndrome (ODS) has a low incidence but is a life-threatening neurological disorder whose common cause is rapid overcorrection of chronic hyponatremia. Transcatheter aortic valve replacement (TAVR) is a new and important therapy for patients with aortic valve stenosis. In this article, we discuss the case of a 64-year-old woman who developed ODS after TAVR and provide a literature review.

Case Presentation: A 64-year-old female patient was admitted to the hospital with chest tightness, shortness of breath, and fatigue for 2 months, with worsening of symptoms for 3 days prior to presentation. Auscultation revealed crackles in the lung fields, and systolic murmurs could be easily heard in the aortic area. Echocardiography showed severe aortic stenosis. Chest X-ray showed pulmonary oedema. Laboratory examinations showed that her serum sodium was 135 mmol/L. The patient received a diuretic to relieve her symptoms but showed little benefit. Her symptoms worsened, and her blood pressure dropped. Then, she underwent emergency TAVR under extracorporeal membrane oxygenation (ECMO) support. After the operation, her urine output increased markedly, and serum sodium increased sharply from 140 to 172 mmol/L. An MRI scan showed multiple lesions in the pons suggestive of ODS.

Conclusion: To date, this is the first reported case of a patient who developed ODS after receiving TAVR. In current clinical practice, diuretics are often used in aortic stenosis patients because of pulmonary oedema. After a patient receives TAVR, kidney perfusion pressure quickly returns to normal, and with the residual effect of a high-dose diuretic, balances of fluid volume and electrolyte levels in this phase are quite fragile and must be carefully managed. If a patient has neurological symptoms/signs during this phase, ODS should be considered, and MRI might be necessary.
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http://dx.doi.org/10.3389/fmed.2022.915981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251175PMC
June 2022

Endovascular treatment of type B aortic dissection in patients with end-stage renal disease.

Vascular 2022 Jul 5:17085381221112550. Epub 2022 Jul 5.

Department of Vascular Surgery, Zhongshan Hospital, Shanghai, China.

Objectives: This study aimed to evaluate the postoperative and intermediate outcomes of thoracic endovascular aortic repair (TEVAR) in patients with end-stage renal disease (ESRD).

Methods: We retrospectively reviewed patients with type B aortic dissection (TBAD) undergoing TEVAR at our single center from January 2010 to December 2020. Patients with pre-existing ESRD were enrolled as the study group. One hundred consecutive patients from September 2013 to March 2015 without ESRD were included as the control group. The primary and secondary outcomes were adverse events and survival, respectively. Kaplan-Meier curves of survival and freedom from adverse events were calculated and analyzed using the log-rank univariate test. Multivariable analysis was used to isolate the effects of ESRD.

Results: A total of 39 patients with ESRD and TBAD underwent TEVAR during the study period. The median follow-up time of patients with and without ESRD was 45 and 46 months, respectively. There was significant difference between the survival at 4 years of patients with and without ESRD (72.8% vs 94.9%; = 0.011). Meanwhile, the incidence of adverse events was significantly higher in patients with ESRD ( = 0.026). Multivariable logistic regression analysis showed that ESRD (OR, 2.46; = 0.049) and peripheral artery disease (OR, 4.11; = 0.002) were the predictors of adverse events.

Conclusions: The rates of adverse events and survival expectancy were poor in patients with ESRD and TBAD.
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http://dx.doi.org/10.1177/17085381221112550DOI Listing
July 2022

Surgical Management of Cardiac Masses in Right Atrium Among Bone Sarcoma Pediatric Patients With Totally Implanted Ports.

Front Oncol 2022 16;12:926387. Epub 2022 Jun 16.

Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Introduction: Totally implanted ports (PORTs) have been widely used among patients with malignancy. Cardiac metastasis secondary to bone sarcoma and catheter-related right atrial thrombosis (CRAT) can be both present as cardiac masses. However, these two cardiac masses share very similar imaging characteristics.

Methods: The features, treatments, and outcomes of 5 bone sarcoma pediatric patients with PORTs who suffered from cardiac masses in the right atrium were analyzed. Clinical data and histological characteristics of cardiac masses were also recorded.

Results: Among 928 patients with malignancy and PORTs, 5 bone sarcoma pediatric patients were found to have cardiac masses in the right atrium. The catheter tips were located in the right atrium of 4 patients and the superior vena cava-right atrium junction (CAJ) of 1 patient. Four patients with good response to anti-tumor treatment had received surgical lumpectomies for pathologic identification and mass excision, with cardiac metastases among 1 patient and thromboses among 3 patients. The median time from venous access port implantation to cardiac mass detection for CRAT was 6.3 months (range: 4.7-6.8 months) and to diagnosis of or possible cardiac metastasis was 13.3 months (range: 11.2-15.4 months).

Conclusion: The placement of a catheter tip into the right atrium should be avoided. The time from PORTs implantation to cardiac mass detection might serve as a potential tool to differentiate cardiac metastasis from CRAT. Surgical management may be an effective treatment for bone sarcoma pediatric patients who had good response to anti-tumor treatment and suffered from cardiac masses in the right atrium.
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http://dx.doi.org/10.3389/fonc.2022.926387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246414PMC
June 2022

The PI3K/AKT signalling pathway in inflammation, cell death and glial scar formation after traumatic spinal cord injury: Mechanisms and therapeutic opportunities.

Cell Prolif 2022 Jun 26:e13275. Epub 2022 Jun 26.

Department of Orthopedics, Lanzhou University Second Hospital, Lanzhou, China.

Objects: Traumatic spinal cord injury (TSCI) causes neurological dysfunction below the injured segment of the spinal cord, which significantly impacts the quality of life in affected patients. The phosphoinositide 3kinase/serine-threonine kinase (PI3K/AKT) signaling pathway offers a potential therapeutic target for the inhibition of secondary TSCI. This review summarizes updates concerning the role of the PI3K/AKT pathway in TSCI.

Materials And Methods: By searching articles related to the TSCI field and the PI3K/AKT signaling pathway, we summarized the mechanisms of secondary TSCI and the PI3K/AKT signaling pathway; we also discuss current and potential future treatment methods for TSCI based on the PI3K/AKT signaling pathway.

Results: Early apoptosis and autophagy after TSCI protect the body against injury; a prolonged inflammatory response leads to the accumulation of pro-inflammatory factors and excessive apoptosis, as well as excessive autophagy in the surrounding normal nerve cells, thus aggravating TSCI in the subacute stage of secondary injury. Initial glial scar formation in the subacute phase is a protective mechanism for TSCI, which limits the spread of damage and inflammation. However, mature scar tissue in the chronic phase hinders axon regeneration and prevents the recovery of nerve function. Activation of PI3K/AKT signaling pathway can inhibit the inflammatory response and apoptosis in the subacute phase after secondary TSCI; inhibiting this pathway in the chronic phase can reduce the formation of glial scar.

Conclusion: The PI3K/AKT signaling pathway has an important role in the recovery of spinal cord function after secondary injury. Inducing the activation of PI3K/AKT signaling pathway in the subacute phase of secondary injury and inhibiting this pathway in the chronic phase may be one of the potential strategies for the treatment of TSCI.
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http://dx.doi.org/10.1111/cpr.13275DOI Listing
June 2022

Pressure-Enhanced Photocurrent in One-Dimensional SbSI via Lone-Pair Electron Reconfiguration.

Materials (Basel) 2022 May 27;15(11). Epub 2022 May 27.

Center for High Pressure Science and Technology Advanced Research, Shanghai 201203, China.

Understanding the relationships between the local structures and physical properties of low-dimensional ferroelectrics is of both fundamental and practical importance. Here, pressure-induced enhancement in the photocurrent of SbSI is observed by using pressure to regulate the lone-pair electrons (LPEs). The reconfiguration of LPEs under pressure leads to the inversion symmetry broken in the crystal structure and an optimum bandgap according to the Shockley-Queisser limit. The increased polarization caused by the stereochemical expression of LPEs results in a significantly enhanced photocurrent at 14 GPa. Our research enriches the foundational understanding of structure-property relationships by regulating the stereochemical role of LPEs and offers a distinctive approach to the design of ferroelectric-photovoltaic materials.
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http://dx.doi.org/10.3390/ma15113845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182005PMC
May 2022

Premature Termination Codon of Gene Improves Cookie Quality in Ningmai9 Wheat.

Front Plant Sci 2022 12;13:835164. Epub 2022 May 12.

Jiangsu Co-innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Lab of Crop Genomics and Molecular Breeding, Yangzhou University, Yangzhou, China.

The area between middle and lower reaches of the Yangtze River is the largest region for soft wheat production in China. In soft wheat breeding, the lack of germplasm with desirable quality for end-use products is a barrier. Ningmai9 is the main variety of soft wheat planted in this area. To create germplasm with better quality and yield potential than Ningmai9, mutants of HMW-GSs in Ningmai9 induced by ethylmethanesulfonate (EMS) were obtained. SDS-PAGE showed that two mutants, md10 and md11, were HMW-GS 1Dy deletions. DNA sequencing confirmed that one mutation was caused by a C/T substitution, resulting in the change of CAA encoding glutamine into the termination codon TAA, and another mutation was due to a G/A substitution in the central repetitive domain of the coding region, causing TGG encoding tryptophan to become the termination codon TGA. The premature termination codon of the gene affected the expression of and kept the mRNA at a lower transcription level during the kernel development stage in comparison with the wild type. HMW-GS 1Dy12 deletion mutants decreased the content of HMW-GSs and glutenin macropolymers, mixograph envelope peak time and TIMEX width, water solvent retention capacity (WSRC), and lactic acid solvent retention capacity (LASRC). In the HMW-GS 1Dy12 deletion lines, the sugar-snap cookie diameter was 8.70-8.74 cm, which was significantly larger than that in the wild type of 8.0 cm. There were no significant differences in spike number, kernel number, thousand kernel weight, and yield between the deletion lines and wild type. Overall, the study indicated that the knockout of the gene induced by EMS is an effective way to improve wheat quality, and deletion mutants of HMW-GS 1Dy12 decrease gluten strength and increase sugar snap cookie diameter without yield penalty in Ningmai9 wheat.
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http://dx.doi.org/10.3389/fpls.2022.835164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9134186PMC
May 2022

VPO F Fluorophosphates Polyanion Cathodes for High-Voltage Proton Storage.

Angew Chem Int Ed Engl 2022 Aug 21;61(32):e202206635. Epub 2022 Jun 21.

Department of Chemistry, Department of Materials Science, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200433, China.

Proton batteries are emerging in electrochemical energy storage because of the associated fast kinetics, low cost and high safety. However, their development is hindered by the relatively low energy density due to the limited choice of cathode materials. Herein, metal phosphate polyanion cathodes are proposed as the proton cathode for the first time. Combining experimental results and theoretical simulations, a universal criterion for the proton cathode was put forward. Vanadium fluorophosphate (VPO F) was demonstrated as a promising high-voltage proton cathode material with a specific capacity of 116 mAh g at a high potential of 1.0 V (vs. SHE). The proton insertion/extraction mechanism in the VPO F electrode was also verified through X-ray diffraction (XRD) and photoelectron spectroscopy (XPS). Furthermore, the stability of VPO F was investigated in various electrolytes and the optimized electrolyte enabled the stable operation of VPO F for 300 cycles. This work provides new inspiration in the exploitation of new electrode materials for electrochemical proton storage devices.
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http://dx.doi.org/10.1002/anie.202206635DOI Listing
August 2022

Improved growth and metabolite accumulation in Codonopsis pilosula (Franch.) Nannf. by inoculation with the endophytic Geobacillu sp. RHBA19 and Pseudomonas fluorescens RHBA17.

J Plant Physiol 2022 Jul 13;274:153718. Epub 2022 May 13.

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.

In this study, we focused on the plant-growth-promoting properties of two strains isolated from Codonopsis pilosula, and the effect of inoculation with different strain treatments on physiological and metabolite accumulation of C. pilosula. The strains RHBA19 and RHBA17 were isolated and identified as Geobacillu sp. and Pseudomonas fluorescens, respectively. The two strains produced indole acetic acid (IAA), siderophore, biofilm, and various exoenzymes. Based on the pot experiments, inoculation of RHBA19 (G group) and the two mixed bacteria (M group) significantly improved the growth, root development, and photosynthesis of C. pilosula. Compared with the no-inoculation group (CK), the total polysaccharide content of root in the G and M groups was dramatically enhanced by 59.27% and 96.07%, and the lobetyolin (root) improved by 58.4% and 66.0%, respectively. After inoculation with bacteria agents, the activities of antioxidant enzymes (CAT, POD, SOD) of C. pilosula increased differentially. Inoculation with two types of bacterial agents significantly increased the activities of sucrose synthase (SS) and sucrose phosphate synthase (SPS) in root, and phenylalanine ammonia lyase (PAL) in leaf of C. pilosula. In addition, the content of signaling molecules (NO and HO) in three types of tissue increased significantly. The magnitude of these results was higher with mixtures than with individual strains. These results imply that the two types of bacterial agents induce physiological metabolism changes to accumulate polysaccharides and lobetyolin by regulating stress resistance enzymes and signal molecules, especially NO and HO.
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http://dx.doi.org/10.1016/j.jplph.2022.153718DOI Listing
July 2022

Preparation and Characterization of Polysaccharide-Based Hydrogels for Cutaneous Wound Healing.

Polymers (Basel) 2022 Apr 22;14(9). Epub 2022 Apr 22.

School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China.

Natural hydrogels are growing in interest as a priority for wound healing. Plant polysaccharides have a variety of biological pharmacological activities, and chitosan hydrogels have proven strong antimicrobial effects, but hydrogels prepared with polysaccharides alone have certain deficiencies. Polysaccharides from flowers of Thunb. (LP) and the aerial parts of L. (MP) were extracted and oxidized by sodium periodate (NaIO) and then cross-linked with oxidized-carboxymethylated chitosan (O-CCS) to develop oxidized plant- polysaccharides-chitosan hydrogels (OPHs). SEM observation showed that OPHs had porous interior structures with interconnecting pores. The OPHs showed good swelling, water-retention ability, blood coagulation, cytocompatibility properties, and low cytotoxicity (classed as grade 1 according to United States Pharmacopoeia), which met the requirements for wound dressings. Then the cutaneous wound-healing effect was evaluated in BALB/C mice model, after 7 days treatment, the wound-closure rate of OPHs groups were all greater than 50%, and after 14 days, all were greater than 90%, while the value of the control group was only 72.6%. Of them, OPH-2 and OPH-3 were more favorable to the wound-healing process, as the promotion was more significant. The plant polysaccharides and CS-based hydrogel should be a candidate for cutaneous wound dressings.
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http://dx.doi.org/10.3390/polym14091716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105569PMC
April 2022

Establishment and Application of the Assessment System on Ecosystem Health for Restored Urban Rivers in North China.

Int J Environ Res Public Health 2022 05 5;19(9). Epub 2022 May 5.

Beijing Municipal Research Institute of Eco-Environment Protection, National Engineering Research Center for Urban Environmental Pollution Control, Beijing 100037, China.

The study on ecosystem health evaluation for restored urban rivers is of specific significance to improving river health and realizing the adaptive management for urban river ecosystems. Based on the health definition of restored urban rivers in North China, this study attempted to set up a system of alternative indicators on ecosystem health assessment, including water quality, water regime, aquatic organism, riparian environment, and physical morphology. Additionally, a set of health assessment system was proposed, including selection of assessment indexes and determination of assessment criteria and health classes. Taking seventeen typical restored urban rivers in Beijing as the assessment target, the said system was applied in assessing urban river health in 2016 and 2019. As the assessment results indicated, in 2016, the health statuses of 29 percent of urban rivers were ordinary, while 71 percent of urban rivers were somewhat inferior. In 2019, the health state of only one urban river reached "good" level. The health statuses of 88 percent of urban rivers were ordinary, and 6 percent were somewhat inferior in terms of comprehensive health index. In 2019, the health states of rivers improved significantly compared with that of 2016, which indicated that most urban rivers saw marked improvement in ecosystem health after ecological restoration. The health assessment system proposed in the paper not only could be applied to regular evaluation of restored urban rivers in the north but also was suitable for a contrastive health-state analysis between different years prior to or after the restoration. In order to carry out adaptive management of water ecology in urban rivers, the measures of ecological restoration could be adjusted based on the regular health assessment and health weakness analysis.
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http://dx.doi.org/10.3390/ijerph19095619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105896PMC
May 2022

Development and Comparison of Multimodal Models for Preoperative Prediction of Outcomes After Endovascular Aneurysm Repair.

Front Cardiovasc Med 2022 26;9:870132. Epub 2022 Apr 26.

Department of Vascular Surgery, Zhongshan Hospital, Institute of Vascular Surgery, Fudan University, National Clinical Research Center for Interventional Medicine, Shanghai, China.

Objective: The aim of this study was to develop and compare multimodal models for predicting outcomes after endovascular abdominal aortic aneurysm repair (EVAR) based on morphological, deep learning (DL), and radiomic features.

Methods: We retrospectively reviewed 979 patients (January 2010-December 2019) with infrarenal abdominal aortic aneurysms (AAAs) who underwent elective EVAR procedures. A total of 486 patients (January 2010-December 2015) were used for morphological feature model development and optimization. Univariable and multivariable analyses were conducted to determine significant morphological features of EVAR-related severe adverse events (SAEs) and to build a morphological feature model based on different machine learning algorithms. Subsequently, to develop the morphological feature model more easily and better compare with other modal models, 340 patients of AAA with intraluminal thrombosis (ILT) were used for automatic segmentation of ILT based on deep convolutional neural networks (DCNNs). Notably, 493 patients (January 2016-December 2019) were used for the development and comparison of multimodal models (optimized morphological feature, DL, and radiomic models). Of note, 80% of patients were classified as the training set and 20% of patients were classified as the test set. The area under the curve (AUC) was used to evaluate the predictive abilities of different modal models.

Results: The mean age of the patients was 69.9 years, the mean follow-up was 54 months, and 307 (31.4%) patients experienced SAEs. Statistical analysis revealed that short neck, angulated neck, conical neck, ILT, ILT percentage ≥51.6%, luminal calcification, double iliac sign, and common iliac artery index ≥1.255 were associated with SAEs. The morphological feature model based on the support vector machine had a better predictive performance with an AUC of 0.76, an accuracy of 0.76, and an F1 score of 0.82. Our DCNN model achieved a mean intersection over union score of more than 90.78% for the segmentation of ILT and AAA aortic lumen. The multimodal model result showed that the radiomic model based on logistics regression had better predictive performance (AUC 0.93, accuracy 0.86, and F1 score 0.91) than the optimized morphological feature model (AUC 0.62, accuracy 0.69, and F1 score 0.81) and the DL model (AUC 0.82, accuracy 0.85, and F1 score 0.89).

Conclusion: The radiomic model has better predictive performance for patient status after EVAR. The morphological feature model and DL model have their own advantages and could also be used to predict outcomes after EVAR.
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http://dx.doi.org/10.3389/fcvm.2022.870132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9086541PMC
April 2022

Fibrinogen-Albumin Ratio Index Exhibits Predictive Value of Neoadjuvant Chemotherapy in Osteosarcoma.

Cancer Manag Res 2022 5;14:1671-1682. Epub 2022 May 5.

Department of Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China.

Purpose: Inflammatory response and nutritional status are associated with cancer development and progression. The present study aimed to evaluate the predictive ability of the fibrinogen-albumin ratio index (FARI) to the efficacy of neoadjuvant chemotherapy (NAC) for osteosarcoma.

Patients And Methods: A retrospective analysis involving 752 consecutive osteosarcoma patients between 2012 and 2020 was performed. Data on serum fibrinogen, albumin levels, white blood cell count, platelet count, and alkaline phosphatase (ALP) before and after NAC were collected. The predictive value of the NAC efficacy in osteosarcoma was assessed by constructing a receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC). Prognosis and its predictive factors were analyzed by Kaplan-Meier method and COX regression analysis. Nomogram was established according to selected variables. The predictive performance of the nomogram model was assessed using C-statistics.

Results: A total of 203 patients were included. ROC analysis showed that both FARI before NAC (preFARI; AUC = 0.594, = 0.032) and the change in FARI before and after NAC (dfFARI = preFARI-postFARI; AUC = 0.652, = 0.001) exhibited more favorable predictive ability than ALP and other inflammation markers. The preFARI was divided into the high group (>6.1%) and the low group (≤6.1%) based on the optimal cut-off value of 6.1%. Patients with a high preFARI showed significantly decreased metastasis-free survival (MFS) and disease-free survival (DFS) (all <0.01). In multivariable analysis, preFARI was an independent prognostic marker for patients with osteosarcoma. Predictive nomograms exhibited good ability to predict MFS (C-index = 0.748, se = 0.028) and DFS (C-index=0.727, se = 0.030).

Conclusion: Our findings indicated that FARI exhibits the favorable predictive ability for the efficacy of NAC for osteosarcoma, which could support clinicians and patients in clinical decision-making and treatment optimization.
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http://dx.doi.org/10.2147/CMAR.S358310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084387PMC
May 2022

Hierarchical Sulfide-Rich Modification Layer on SiO/C Anode for Low-Temperature Li-Ion Batteries.

Adv Sci (Weinh) 2022 Jul 7;9(20):e2104531. Epub 2022 May 7.

Tianjin Key Laboratory for Photoelectric Materials and Devices, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin, 300384, China.

The silicon oxide/graphite (SiO/C) composite anode represents one of the promising candidates for next generation Li-ion batteries over 400 Wh kg . However, the rapid capacity decay and potential safety risks at low temperature restrict their widely practical applications. Herein, the fabrication of sulfide-rich solid electrolyte interface (SEI) layer on surface of SiO/C anode to boost the reversible Li-storage performance at low temperature is reported. Different from the traditional SEI layer, the present modification layer is composed of inorganic-organic hybrid components with three continuous layers as disclosed by time-of-flight secondary ion mass spectrometry (TOF-SIMS). The result shows that ROSO Li, ROCO Li, and LiF uniformly distribute over different layers. When coupled with LiNi Co Mn O cathode, the capacity retention achieves 73% at -20 °C. The first principle calculations demonstrate that the gradient adsorption of sulfide-rich surface layer and traditional intermediate layer can promote the desolvation of Li at low temperature. Meanwhile, the inner LiF-rich layer with rapid ionic diffusion capability can inhibit dendrite growth. These results offer new perspective of developing advanced SiO/C anode and low-temperature Li-ion batteries.
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http://dx.doi.org/10.1002/advs.202104531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9284185PMC
July 2022

Differences in geological conditions have reshaped the structure and diversity of microbial communities in oily soils.

Environ Pollut 2022 Aug 3;306:119404. Epub 2022 May 3.

School of Petrochemical Engineering, Lanzhou University of Technology, Lanzhou, 730050, China.

High-throughput sequencing was used to study the microbial community structure diversity changes in oil-contaminated soils under different spatial distances and environmental conditions. 239 Phyla, 508 Classes, 810 Orders, 1417 Families, 2048 Genera, 511 Species of microbial communities were obtained from 16 samples in three regions. The physicochemical properties of the soil, microorganisms' community structure has been changed by Petroleum hydrocarbon (PHA). Alpha diversity results showed that the soil contained high bacterial diversity, especially in Qingyang's loess soil. The bacterial abundance was in the order of loess soil > black soil > sandy soil. Beta diversity revealed that spatial distance limitation and random variation of repeated samples may be the main factors leading to soil heterogeneity and microbial community structure differences. The dominant bacteria phyla with broad petroleum hydrocarbon degradation ability such as Proteobacteria, Firmicutes, Bacteroidetes and Actinobacteria were identified. Pseudomonas, Bacillus, Nocardioides, Oceanobacillus, Sphingomonas, Alkanindiges and Streptomyces were identified as functional microbial for the PHA degradation. The microbial communities manifested the co-exclusion under different geological conditions, and played the key role in the soil PHA degradation through amino acid metabolism, energy metabolism and carbohydrate metabolism. The correlation results of amos structural equation showed that the diversity and abundance of soil microorganisms in different regions were controlled by soil PHA content and environmental factors. Altitude, annual average temperature and annual rainfall were positively correlated with microbial diversity. Annual rainfall and soil physical and chemical factors exhibited the most significant influence on it. Microbial diversity indirectly affected the PHA content in different type soil. We believe that reshape the structure and diversity of microbial communities in soil could be changed and reshaped by different geological conditions, pollutants and soil type. This study can provide helps for understanding the ecological effect of geomicrobiology formation under the driving force of geographic environment and other factors.
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http://dx.doi.org/10.1016/j.envpol.2022.119404DOI Listing
August 2022

Probing individual-level structural atrophy in frontal glioma patients.

Neurosurg Rev 2022 Aug 4;45(4):2845-2855. Epub 2022 May 4.

Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Brian Tumor, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.

Although every glioma patient varies in tumor size, location, histological grade and molecular biomarkers, non-tumoral morphological abnormalities are commonly detected by a statistical comparison among patient groups, missing the information of individual morphological alterations. In this study, we introduced an individual-level structural abnormality detection method for glioma patients and proposed several abnormality indexes to depict individual atrophy patterns. Forty-five patients with a glioma in the frontal lobe and fifty-one age-matched healthy controls participated in the study. Individual structural abnormality maps (SAM) were generated using patients' preoperative T1 images, by calculating the degree of deviation of voxel volume in each patient with the normative model built from healthy controls. Based on SAM, a series of individual abnormality indexes were computed, and their relationship with glioma characteristics was explored. The results demonstrated that glioma patients showed unique non-tumoral atrophy patterns with overlapping atrophy regions mainly located at hippocampus, parahippocampus, amygdala, insula, middle temporal gyrus and inferior temporal gyrus, which are closely related to the human cognitive functions. The abnormality indexes were associated with several molecular biomarkers including isocitrate dehydrogenase (IDH) mutation, 1p/19q co-deletion and telomerase reverse transcriptase (TERT) promoter mutation. Our study provides an effective way to access the individual-level non-tumoral structural abnormalities in glioma patients, which has the potential to significantly improve individualized precision medicine.
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http://dx.doi.org/10.1007/s10143-022-01800-9DOI Listing
August 2022

Simultaneously achieving giant piezoelectricity and record coercive field enhancement in relaxor-based ferroelectric crystals.

Nat Commun 2022 May 4;13(1):2444. Epub 2022 May 4.

Center for High Pressure Science and Technology Advanced Research, 201203, Shanghai, China.

A large coercive field (E) and ultrahigh piezoelectricity are essential for ferroelectrics used in high-drive electromechanical applications. The discovery of relaxor-PbTiO crystals is a recent breakthrough; they currently afford the highest piezoelectricity, but usually with a low E. Such performance deterioration occurs because high piezoelectricity is interlinked with an easy polarization rotation, subsequently favoring a dipole switch under small fields. Therefore, the search for ferroelectrics with both a large E and ultrahigh piezoelectricity has become an imminent challenge. Herein, ternary Pb(ScNb)O-Pb(MgNb)O-PbTiO crystals are reported, wherein the dispersed local heterogeneity comprises abundant tetragonal phases, affording a E of 8.2 kV/cm (greater than that of Pb(MgNb)O-PbTiO by a factor of three) and ultrahigh piezoelectricity (d = 2630 pC/N; d = 490 pC/N). The observed E enhancement is the largest reported for ultrahigh-piezoelectric materials, providing a simple, practical, and universal route for improving functionalities in ferroelectrics with an atomic-level understanding.
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http://dx.doi.org/10.1038/s41467-022-29962-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9068613PMC
May 2022

Y-shaped branched ventriculo-peritoneal shunt for adult multiloculated hydrocephalus.

Chin Med J (Engl) 2022 04 20;135(8):980-982. Epub 2022 Apr 20.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing Neurosurgical Institute, China National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Brain Tumor Laboratory, Beijing 100070, China.

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http://dx.doi.org/10.1097/CM9.0000000000001961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9276358PMC
April 2022

Effects of Silicone Mattress Combined with Hydrocolloid Dressing on Pressure Ulcers and Phlebitis in ICU Patients with Liver Failure.

Comput Math Methods Med 2022 15;2022:7828650. Epub 2022 Apr 15.

Department of Critical Care Medicine, The Fifth Medical Center of Chinese PLA General Hospital, 100039 Beijing, China.

Objective: This study was aimed at clarifying the application effect of silicone mattress combined with hydrocolloid dressing in ICU patients with liver failure.

Methods: A total of 86 patients with liver failure admitted to the intensive care unit (ICU) of the Fifth Medical Center of Chinese PLA General Hospital from September 2018 to September 2020 were selected as the research subjects. Patients treated with conventional sponge mattress and routine nursing care were included in group A ( = 43), and those treated with silicone mattress combined with hydrocolloid dressing were included in group B ( = 43). The incidence of pressure ulcers and phlebitis, the scores of Visual Analogue Scale (VAS) and Pittsburgh Sleep Quality Index (PSQI), and the nursing satisfaction were observed and compared between the two groups.

Results: The incidence of pressure ulcers in group B (6.98%) was lower than that in group A (25.58%). The incidence of phlebitis in group B was lower than that in group A (20.93% vs. 53.49%). The VAS score of group B was 2.16 ± 0.38, which was lower than that of group A (4.86 ± 1.09). The PSQI score of group B was lower than that of group A (9.74 ± 2.76 vs. 14.84 ± 3.95). A higher nursing satisfaction was determined in group B compared with group A (93.02% vs. 76.74%).

Conclusions: Silicone mattress combined with hydrocolloid dressing can reduce the incidence of pressure ulcers and phlebitis in ICU patients with liver failure, reduce complications, and improve nursing satisfaction, which is worthy of clinical promotion.
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http://dx.doi.org/10.1155/2022/7828650DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9033363PMC
April 2022

Inhibition of PDE10A-Rescued TBI-Induced Neuroinflammation and Apoptosis through the cAMP/PKA/NLRP3 Pathway.

Evid Based Complement Alternat Med 2022 12;2022:3311250. Epub 2022 Apr 12.

Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

Phosphodiesterase 10A (PDE10A) is a dual-substrate phosphodiesterase that is highly expressed in the striatal complex. PDE10A is an important target for the treatment of ganglion dysfunction and neuroinflammation-related diseases, but its possible impact on traumatic brain injury (TBI) is still unclear. This study aims to investigate the protective effects of inhibiting PDE10A on neuroinflammation post-TBI injury and its possible molecular mechanism. The expression of PDE10A in rats and HT22 cells was determined by Western blotting. The neurological dysfunction of these rats was detected by Nissl staining, hematoxylin-eosin (HE) staining, and Morris water maze test. The activity of HT22 cells was measured by MTT. The findings of this study suggest that PDE10A is highly expressed in the brain tissue of TBI rats and HT22 cells induced by mechanical injury. Inhibition of PDE10A reduces the expression of interleukin-1 (IL-1) and interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-) in HT22 cells induced by mechanical injury to inhibit cell apoptosis. Simultaneously, inhibition of PDE10A in TBI rats reduces the time to find a visible platform in the same pool, while cAMP/PKA activator treatment alleviates all of the abovementioned phenomena. Additionally, it is further confirmed that inhibition of PDE10A activates the cAMP/PKA pathway and downregulates the expression of NRLP3. These findings demonstrate that inhibition of PDE10A exerts neuroprotection by inhibiting apoptosis and inflammation following TBI, at least partially by the cAMP/PKA/NLRP3 pathway.
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http://dx.doi.org/10.1155/2022/3311250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019408PMC
April 2022

Spiral molecules with antimalarial activities: A review.

Eur J Med Chem 2022 Jul 8;237:114361. Epub 2022 Apr 8.

Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou, Guangdong, 510260, China. Electronic address:

Malaria is a prevalent fatal disease in tropical and subtropical regions around the world. Combinations of Artemisinin, folate antagonists, quinolines, and antibiotics are major choices in clinics. Currently, wide range of parasite's resistance necessitates the search for chemical compounds with new structures and novel antimalarial targets. The literature review was performed covering the relevant literatures published from 1966 to 2021. On the basis of structural classification (spiro-peroxides, spiroindolones, spirocyclohexadienones et al.), different types of molecules were summarized with resources, anti-malarial activities, structure-activity relationship, target introductions, resistance, development progress, and synthetic strategies, for the purpose of providing comprehensive information for developing antimalarial drugs to overcome drug resistance and highlighting the importance of the spiral structure in medicinal chemistry.
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http://dx.doi.org/10.1016/j.ejmech.2022.114361DOI Listing
July 2022

A radiomics model for predicting the outcome of endovascular abdominal aortic aneurysm repair based on machine learning.

Vascular 2022 Apr 19:17085381221091061. Epub 2022 Apr 19.

Department of Vascular Surgery, National Clinical Research Center for Interventional Medicine, Institute of Vascular Surgery, 92323Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: This study aimed to develop a radiomics model to predict the outcome of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysm (AAA), based on machine learning (ML) algorithms.

Methods: We retrospectively reviewed 711 patients with infra-renal AAA who underwent elective EVAR procedures between January 2016 and December 2019 at our single center. The radiomics features of AAA were extracted using Pyradiomics. Pearson correlation analysis, analysis of variance (ANOVA), least absolute shrinkage, and selection operator (LASSO) regression were applied to determine the predictors for EVAR-related severe adverse events (SAEs). Eighty percent of patients were classified as the training set and the remaining 20 percent of patients were classified as the test set. The selected features were used to build a radiomics model in training set using different ML algorithms. The performance of each model was assessed using the area under the curve (AUC) from the receiver operating characteristic (ROC) curve in the test set.

Results: A total of 493 patients were enrolled in this study, the mean follow-up time was 32 months. During the follow-up, 156 (31.6%) patients experienced EVAR-related SAEs. A total of 1223 radiomics features were extracted from each patient, of which 30 radiomics features were finally identified. The quantitative performance assessment and the ROC curves indicated that the logistics regression (LR) model had better predictive value than others, with accuracy, 0.86; AUC, 0.93; and F1 score, 0.91. The Rad-score waterfall plot showed that the overall amount of error was small both in the training set and in the test set. Calibration curve showed that the calibration degree of the training set and the test set were good ( > 0.05). Decision curve analysis (threshold 0.32) demonstrated that the model had good clinical applicability.

Conclusion: Our radiomics model could be used as an efficient and adjunctive tool to predict the outcome after EVAR.
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http://dx.doi.org/10.1177/17085381221091061DOI Listing
April 2022
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