Yongcheng Song

Yongcheng Song

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Yongcheng Song

Publications by authors named "Yongcheng Song"

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Sugar and iron: Toward understanding the antibacterial effect of ciclopirox in Escherichia coli.

PLoS One 2019 11;14(1):e0210547. Epub 2019 Jan 11.

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210547PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329577PMC
November 2019

Thermodynamic investigation of DNA-binding affinity of wild-type and mutant transcription factor RUNX1.

PLoS One 2019 2;14(5):e0216203. Epub 2019 May 2.

Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216203PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497270PMC
May 2019

Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21).

Theranostics 2018 8;8(8):2189-2201. Epub 2018 Mar 8.

Department of Pharmacology and Chemical Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.7150/thno.22800DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928880PMC
April 2019

Correction: Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma.

Oncotarget 2019 02 22;10(16):1603. Epub 2019 Feb 22.

Department of Infectious Disease, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://www.oncotarget.com/fulltext/26743
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http://dx.doi.org/10.18632/oncotarget.26743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422187PMC
February 2019

Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer.

Med Chem 2018 ;14(7):715-724

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States.

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http://dx.doi.org/10.2174/1573406414666180524093659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205205PMC
October 2018

Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1.

PLoS One 2017 3;12(2):e0170301. Epub 2017 Feb 3.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170301PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291514PMC
August 2017

DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.

Blood 2016 08 22;128(7):971-81. Epub 2016 Jun 22.

Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX; Dan L. Duncan Cancer Center, Department of Molecular and Human Genetics, Stem Cells and Regenerative Medicine Center, and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX;

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http://www.bloodjournal.org/content/bloodjournal/early/2016/
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http://www.bloodjournal.org/cgi/doi/10.1182/blood-2015-11-68
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http://dx.doi.org/10.1182/blood-2015-11-684225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990856PMC
August 2016

Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives.

J Hematol Oncol 2016 06 17;9(1):49. Epub 2016 Jun 17.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13045-016-0279-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912745PMC
June 2016

Antiviral targets of human noroviruses.

Curr Opin Virol 2016 06 17;18:117-25. Epub 2016 Jun 17.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, United States; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.coviro.2016.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4983487PMC
June 2016

Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma.

Oncotarget 2016 May;7(18):26307-30

Department of Infectious Disease, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

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http://dx.doi.org/10.18632/oncotarget.8368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5041982PMC
May 2016

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.

J Hematol Oncol 2016 Mar 12;9:24. Epub 2016 Mar 12.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1186/s13045-016-0252-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789278PMC
March 2016

3-(Piperidin-4-ylmethoxy)pyridine Containing Compounds Are Potent Inhibitors of Lysine Specific Demethylase 1.

J Med Chem 2016 Jan 24;59(1):253-263. Epub 2015 Dec 24.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1021/acs.jmedchem.5b01361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878443PMC
January 2016

Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases by 2-Thiohydantoin Compounds.

J Med Chem 2015 Sep 26;58(17):6899-6908. Epub 2015 Aug 26.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1021/acs.jmedchem.5b00684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4567406PMC
September 2015

DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy.

PLoS One 2014 23;9(5):e98270. Epub 2014 May 23.

Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098270PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032273PMC
June 2015

Inhibition of histone H3K79 methylation selectively inhibits proliferation, self-renewal and metastatic potential of breast cancer.

Oncotarget 2014 Nov;5(21):10665-77

Department of Pharmacology, Baylor College of Medicine, Houston, TX 77030, USA. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279401PMC
http://dx.doi.org/10.18632/oncotarget.2496DOI Listing
November 2014

Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy.

Nat Commun 2014 Nov 17;5:5476. Epub 2014 Nov 17.

Section of Hematology/Oncology, Department of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncomms6476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254804PMC
November 2014

Regioselective radical aminofluorination of styrenes.

Angew Chem Int Ed Engl 2014 Oct 27;53(41):11079-83. Epub 2014 Aug 27.

Department of Chemistry, Northeast Normal University, Changchun, 130024 (China).

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http://doi.wiley.com/10.1002/anie.201406797
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http://dx.doi.org/10.1002/anie.201406797DOI Listing
October 2014

Inhibition of cancer-associated mutant isocitrate dehydrogenases: synthesis, structure-activity relationship, and selective antitumor activity.

J Med Chem 2014 Oct 1;57(20):8307-18. Epub 2014 Oct 1.

Department of Pharmacology, ⊥Department of Pediatrics-oncology, ∥Department of Medicine, and ‡Dan L. Duncan Cancer Center, Baylor College of Medicine , 1 Baylor Plaza, Houston, Texas 77030, United States.

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http://dx.doi.org/10.1021/jm500660fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207540PMC
October 2014

An epigenomic approach to therapy for tamoxifen-resistant breast cancer.

Cell Res 2014 Jul 30;24(7):809-19. Epub 2014 May 30.

1] Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA [2] Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

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http://dx.doi.org/10.1038/cr.2014.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085766PMC
July 2014

Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae.

PLoS One 2013 23;8(7):e69646. Epub 2013 Jul 23.

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069646PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720592PMC
March 2014

A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.

J Med Chem 2013 Nov 14;56(22):8972-83. Epub 2013 Aug 14.

Department of Pharmacology, Baylor College of Medicine , 1 Baylor Plaza, Houston, Texas 77030, United States.

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http://dx.doi.org/10.1021/jm4007752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109313PMC
November 2013

Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.

Medchemcomm 2013 Oct;4(10)

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, United States.

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http://dx.doi.org/10.1039/C3MD00219EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826262PMC
October 2013

Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.

ACS Med Chem Lett 2013 Jun;4(6):542-546

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, United States.

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http://dx.doi.org/10.1021/ml400036zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686309PMC
June 2013

Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.

Medchemcomm 2013 May;4(5):822-826

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, United States. ; Tel: +1 713-798-7415.

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http://dx.doi.org/10.1039/C3MD00021DDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686528PMC
May 2013

Structural basis of substrate specificity and protease inhibition in Norwalk virus.

J Virol 2013 Apr 30;87(8):4281-92. Epub 2013 Jan 30.

Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.

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http://dx.doi.org/10.1128/JVI.02869-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624372PMC
April 2013

Expression, characterization and inhibition of Toxoplasma gondii 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

Bioorg Med Chem Lett 2013 Apr 30;23(7):2158-61. Epub 2013 Jan 30.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/j.bmcl.2013.01.097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602143PMC
April 2013

Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase.

ACS Med Chem Lett 2013 Feb;4(2):278-282

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, United States.

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http://dx.doi.org/10.1021/ml300419rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685428PMC
February 2013

2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases.

Bioorg Med Chem Lett 2012 Oct 10;22(19):6229-32. Epub 2012 Aug 10.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, United States.

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http://dx.doi.org/10.1016/j.bmcl.2012.08.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463135PMC
October 2012

Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase.

ACS Med Chem Lett 2012 Jun 7;3(6):496-500. Epub 2012 May 7.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, United States.

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http://pubs.acs.org/doi/10.1021/ml300071w
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http://dx.doi.org/10.1021/ml300071wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462030PMC
June 2012

Selective inhibitors of histone methyltransferase DOT1L: design, synthesis, and crystallographic studies.

J Am Chem Soc 2011 Oct 4;133(42):16746-9. Epub 2011 Oct 4.

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/ja206312bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492951PMC
October 2011

Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes.

ACS Med Chem Lett 2011 Feb;2(2):165-170

Department of Pharmacology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030.

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http://dx.doi.org/10.1021/ml100243rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046873PMC
February 2011

Biochemical control of CARM1 enzymatic activity by phosphorylation.

J Biol Chem 2009 Dec 20;284(52):36167-74. Epub 2009 Oct 20.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1074/jbc.M109.065524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794732PMC
December 2009

Coordination chemistry based approach to lipophilic inhibitors of 1-deoxy-D-xylulose-5-phosphate reductoisomerase.

J Med Chem 2009 Nov;52(21):6539-42

Department of Pharmacology, Baylor College of Medicine, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1021/jm9012592DOI Listing
November 2009

Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results.

J Med Chem 2009 Jul;52(13):3869-80

Department of Chemistry and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1021/jm9001764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753857PMC
July 2009

Photoaffinity antigens for human gammadelta T cells.

J Immunol 2008 Dec;181(11):7738-50

Department of Internal Medicine, Division of Rheumatology, niversity of Iowa College of Medicine, Iowa City, IA 52242, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696061PMC
http://dx.doi.org/10.4049/jimmunol.181.11.7738DOI Listing
December 2008

Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation.

Bioorg Med Chem 2008 Oct 27;16(19):8959-67. Epub 2008 Aug 27.

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA.

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http://dx.doi.org/10.1016/j.bmc.2008.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2586422PMC
October 2008

A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence.

Science 2008 Mar 14;319(5868):1391-4. Epub 2008 Feb 14.

Institute of Biological Chemistry, Academia Sinica, Nankang, Taipei 11529, Taiwan.

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http://dx.doi.org/10.1126/science.1153018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747771PMC
March 2008

NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model.

J Am Chem Soc 2008 Jan 4;130(4):1264-73. Epub 2008 Jan 4.

Center for Biophysics and Computational Biology, 607 South Mathews Avenue, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja0759949
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http://dx.doi.org/10.1021/ja0759949DOI Listing
January 2008

Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.

Proc Natl Acad Sci U S A 2007 Jun 29;104(24):10022-7. Epub 2007 May 29.

Taiwan International Graduate Program, Institute of Biological Chemistry, Core Facility for Protein Crystallography, Academia Sinica, Taipei 115, Taiwan.

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http://dx.doi.org/10.1073/pnas.0702254104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1877987PMC
June 2007

Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.

J Am Chem Soc 2006 Nov;128(45):14485-97

Department of Chemistry and Biophysics, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1021/ja061737cDOI Listing
November 2006

Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines.

J Med Chem 2006 Sep;49(19):5804-14

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm060280e
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http://dx.doi.org/10.1021/jm060280eDOI Listing
September 2006

Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates.

J Med Chem 2006 Jan;49(1):215-23

Department of Biophysics, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1021/jm0582625DOI Listing
January 2006

Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase.

J Med Chem 2005 Sep;48(19):6128-39

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm058220g
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http://dx.doi.org/10.1021/jm058220gDOI Listing
September 2005

A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase.

J Am Chem Soc 2005 Jan;127(2):536-7

Institute de Recherche Wiame and Laboratoire de Microbiologie, Universite Libre de Bruxelles, 1 Avenue E. Gryson, 1070 Bruxelles, Belgium.

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http://dx.doi.org/10.1021/ja040207iDOI Listing
January 2005

Synthesis of chiral phosphoantigens and their activity in gamma delta T cell stimulation.

Bioorg Med Chem Lett 2004 Sep;14(17):4471-7

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, 61801, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X040082
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http://dx.doi.org/10.1016/j.bmcl.2004.06.052DOI Listing
September 2004

Specific inhibition of cyclin-dependent kinases and cell proliferation by harmine.

Biochem Biophys Res Commun 2004 Apr;317(1):128-32

Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore.

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http://dx.doi.org/10.1016/j.bbrc.2004.03.019DOI Listing
April 2004

Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates.

J Med Chem 2004 Jan;47(2):375-84

Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

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http://dx.doi.org/10.1021/jm0303709DOI Listing
January 2004

Beta-carbolines as specific inhibitors of cyclin-dependent kinases.

Bioorg Med Chem Lett 2002 Apr;12(7):1129-32

Medicinal and Combinatorial Chemistry Group, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore.

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http://dx.doi.org/10.1016/s0960-894x(02)00094-xDOI Listing
April 2002