Yong-Yu Liu - University of Louisiana at Monroe - Professor

Yong-Yu Liu

University of Louisiana at Monroe

Professor

Louisiana | United States

Main Specialties: Biochemical Genetics, Molecular Genetic Pathology, Oncology, Pharmacology

Additional Specialties: Pharmacology

Yong-Yu Liu - University of Louisiana at Monroe - Professor

Yong-Yu Liu

Introduction

Primary Affiliation: University of Louisiana at Monroe - Louisiana , United States

Specialties:

Additional Specialties:

Publications

40Publications

1529Reads

-Profile Views

666PubMed Central Citations

An N-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.

Biochem Pharmacol 2019 02 19;160:134-145. Epub 2018 Dec 19.

School of Basic Pharmaceutical and Toxicological Sciences, University of Louisiana at Monroe, Monroe, LA 71201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2018.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407121PMC
February 2019
13 Reads
5.009 Impact Factor

(-)-Oleocanthal Combined with Lapatinib Treatment Synergized against HER-2 Positive Breast Cancer In Vitro and In Vivo.

Nutrients 2019 Feb 15;11(2). Epub 2019 Feb 15.

School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.

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http://dx.doi.org/10.3390/nu11020412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412724PMC
February 2019
267 Reads
3.148 Impact Factor

Highly and moderately aggressive mouse ovarian cancer cell lines exhibit differential gene expression.

Tumour Biol 2016 Aug 2;37(8):11147-11162. Epub 2016 Mar 2.

Department of Biology, Xavier University of Louisiana, 1 Drexel Drive, New Orleans, LA 70125, USA.

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http://dx.doi.org/10.1007/s13277-015-4518-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292133PMC
August 2016
40 Reads
1 Citation
2.840 Impact Factor

Novel Peptidomimetics for Inhibition of HER2:HER3 Heterodimerization in HER2-Positive Breast Cancer.

Chem Biol Drug Des 2015 Jun 6;85(6):702-714. Epub 2014 Nov 6.

Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe LA 71201.

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http://dx.doi.org/10.1111/cbdd.12453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408264PMC
June 2015
15 Reads
6 Citations
2.485 Impact Factor

Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models.

PLoS One 2014 21;9(5):e97622. Epub 2014 May 21.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0097622PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029740PMC
January 2015
47 Reads
18 Citations
3.234 Impact Factor

Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells.

Biochim Biophys Acta 2014 Nov 6;1841(11):1571-80. Epub 2014 Sep 6.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2014.08.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188706PMC
November 2014
41 Reads
7 Citations

Marine natural products-inspired phenylmethylene hydantoins with potent in vitro and in vivo antitumor activities via suppression of Brk and FAK signaling.

Org Biomol Chem 2014 Jul;12(28):5295-303

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71201, USA.

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http://dx.doi.org/10.1039/c4ob00553hDOI Listing
July 2014
55 Reads
6 Citations
3.562 Impact Factor

3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells.

Bioorg Med Chem 2014 Feb 8;22(4):1412-20. Epub 2014 Jan 8.

Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, United States.

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http://dx.doi.org/10.1016/j.bmc.2013.12.065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967587PMC
February 2014
60 Reads
2 Citations
2.793 Impact Factor

New Insights on Glucosylceramide Synthase in Cancer Drug Resistance and Myelosuppression.

Biochem Pharmacol (Los Angel) 2013 Sep;2

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, LA 71209, USA.

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http://dx.doi.org/10.4172/2167-0501.1000120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4229685PMC
September 2013
13 Reads

Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance.

Adv Cancer Res 2013 ;117:59-89

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA, USA.

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http://dx.doi.org/10.1016/B978-0-12-394274-6.00003-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051614PMC
June 2013
13 Reads
31 Citations
5.321 Impact Factor

The opposite effects of doxorubicin on bone marrow stem cells versus breast cancer stem cells depend on glucosylceramide synthase.

Int J Biochem Cell Biol 2012 Nov 19;44(11):1770-8. Epub 2012 Jun 19.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA 71209, USA.

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http://dx.doi.org/10.1016/j.biocel.2012.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3455138PMC
November 2012
66 Reads
7 Citations
4.050 Impact Factor

Ceramide glycosylation by glucosylceramide synthase selectively maintains the properties of breast cancer stem cells.

J Biol Chem 2012 Oct 30;287(44):37195-205. Epub 2012 Aug 30.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA.

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http://dx.doi.org/10.1074/jbc.M112.396390DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481319PMC
October 2012
34 Reads
20 Citations
4.573 Impact Factor

Doxorubicin and MBO-asGCS oligonucleotide loaded lipid nanoparticles overcome multidrug resistance in adriamycin resistant ovarian cancer cells (NCI/ADR-RES).

Int J Pharm 2012 Jul 25;431(1-2):222-9. Epub 2012 Apr 25.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209-0497, USA.

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http://dx.doi.org/10.1016/j.ijpharm.2012.04.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358787PMC
July 2012
45 Reads
3 Citations
3.650 Impact Factor

Resuscitating wild-type p53 expression by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors.

Authors:
Yong-Yu Liu

Cancer Res 2011 Oct 4;71(20):6295-9. Epub 2011 Oct 4.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193566PMC
October 2011
48 Reads
10 Citations
9.330 Impact Factor

Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma.

Int J Oncol 2011 Aug 23;39(2):425-31. Epub 2011 May 23.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA.

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http://dx.doi.org/10.3892/ijo.2011.1052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4037863PMC
August 2011
19 Reads
23 Citations
3.025 Impact Factor

Evaluation of anticancer agents using flow cytometry analysis of cancer stem cells.

Methods Mol Biol 2011 ;716:179-91

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA, USA.

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http://dx.doi.org/10.1007/978-1-61779-012-6_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130503PMC
May 2011
13 Reads
5 Citations

Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells.

Cancer Res 2011 Mar 28;71(6):2276-85. Epub 2011 Jan 28.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71201, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059346PMC
March 2011
27 Reads
21 Citations
9.330 Impact Factor

Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells.

Apoptosis 2011 Mar;16(3):301-10

Department of Pharmacology, Toxicology & Neuroscience, LSU Health Sciences Center in Shreveport, LA 71130, USA.

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http://dx.doi.org/10.1007/s10495-010-0559-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078632PMC
March 2011
41 Reads
13 Citations
3.685 Impact Factor

Sphingolipids and expression regulation of genes in cancer.

Prog Lipid Res 2011 Jan 21;50(1):104-14. Epub 2010 Oct 21.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 71209, USA.

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http://dx.doi.org/10.1016/j.plipres.2010.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3012148PMC
January 2011
15 Reads
24 Citations
10.020 Impact Factor

Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: in vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells.

Int J Pharm 2010 Nov 15;400(1-2):251-9. Epub 2010 Sep 15.

Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209-0497, United States.

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http://dx.doi.org/10.1016/j.ijpharm.2010.08.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952652PMC
November 2010
14 Reads
4 Citations
3.650 Impact Factor

Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches.

Biochem Pharmacol 2010 Aug 10;80(3):308-15. Epub 2010 Apr 10.

John Wayne Cancer Institute at Saint John's Health Center, Department of Experimental Therapeutics, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.1016/j.bcp.2010.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883648PMC
August 2010
26 Reads
23 Citations
5.010 Impact Factor

Direct assessment of P-glycoprotein efflux to determine tumor response to chemotherapy.

Biochem Pharmacol 2010 Jul 16;80(1):72-9. Epub 2010 Mar 16.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA 71209, USA.

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http://dx.doi.org/10.1016/j.bcp.2010.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860649PMC
July 2010
11 Reads
12 Citations
5.010 Impact Factor

Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling.

Mol Cancer 2010 Jun 11;9:145. Epub 2010 Jun 11.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA.

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http://dx.doi.org/10.1186/1476-4598-9-145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903501PMC
June 2010
24 Reads
41 Citations
4.260 Impact Factor

Direct quantitative determination of ceramide glycosylation in vivo: a new approach to evaluate cellular enzyme activity of glucosylceramide synthase.

J Lipid Res 2010 Apr 13;51(4):866-74. Epub 2009 Oct 13.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, LA, USA.

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http://dx.doi.org/10.1194/jlr.D002949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842142PMC
April 2010
51 Reads
14 Citations
4.421 Impact Factor

A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis.

PLoS One 2009 Sep 9;4(9):e6938. Epub 2009 Sep 9.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006938PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735002PMC
September 2009
52 Reads
27 Citations
3.234 Impact Factor

Effect of B7.1 costimulation on T-cell based immunity against TAP-negative cancer can be facilitated by TAP1 expression.

PLoS One 2009 Jul 24;4(7):e6385. Epub 2009 Jul 24.

Department of Cellular Biology and Anatomy, Gene Therapy Program, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006385PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711302PMC
July 2009
22 Reads
3 Citations
3.234 Impact Factor

In vivo survivors of transformed mouse ovarian surface epithelial cells display diverse phenotypes for gene expression and tumorigenicity.

Tumour Biol 2008 3;29(6):359-70. Epub 2008 Dec 3.

Department of Cellular Biology and Anatomy, Gene Therapy Program, Louisiana State University Health Sciences Center, Shreveport, La, USA.

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http://dx.doi.org/10.1159/000178981DOI Listing
February 2009
17 Reads
2 Citations
2.840 Impact Factor

N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing.

Mol Cancer Ther 2008 Sep;7(9):2967-76

Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-0549DOI Listing
September 2008
73 Reads
39 Citations
5.683 Impact Factor

A role for ceramide in driving cancer cell resistance to doxorubicin.

FASEB J 2008 Jul 1;22(7):2541-51. Epub 2008 Feb 1.

Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, 700 University Ave., Monroe, LA 71209, USA.

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http://dx.doi.org/10.1096/fj.07-092981DOI Listing
July 2008
35 Reads
57 Citations
5.043 Impact Factor

Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs.

Cancer Res 2005 May;65(9):3861-7

John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-2329DOI Listing
May 2005
27 Reads
39 Citations
9.330 Impact Factor

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells.

J Lipid Res 2004 May 16;45(5):933-40. Epub 2004 Feb 16.

John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA, USA.

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http://dx.doi.org/10.1194/jlr.M300486-JLR200DOI Listing
May 2004
25 Reads
21 Citations
4.421 Impact Factor

Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy.

Mol Cancer Ther 2004 May;3(5):633-9

John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.

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May 2004
25 Reads
39 Citations
5.683 Impact Factor

Development of a mammalian Tet-on expression cell line: glucosylceramide synthase regulates TNF-alpha-induced apoptosis.

Methods Mol Biol 2004 ;249:177-92

John Wayne Cancer Institute at Saint John's Health Center, Santa Monic, California, USA.

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http://dx.doi.org/10.1385/1-59259-667-3:177DOI Listing
February 2004
26 Reads
2 Citations

Ceramide glycosylation potentiates cellular multidrug resistance.

FASEB J 2001 Mar;15(3):719-30

John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, CA 90404, USA.

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http://dx.doi.org/10.1096/fj.00-0223comDOI Listing
March 2001
9 Reads
70 Citations
5.043 Impact Factor

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance.

J Biol Chem 2000 Mar;275(10):7138-43

John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.

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http://dx.doi.org/10.1074/jbc.275.10.7138DOI Listing
March 2000
12 Reads
18 Citations
4.573 Impact Factor

Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells.

J Biol Chem 1999 Jan;274(2):1140-6

John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California 90404, USA.

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http://dx.doi.org/10.1074/jbc.274.2.1140DOI Listing
January 1999
11 Reads
49 Citations
4.573 Impact Factor

Top co-authors

Vineet Gupta
Vineet Gupta

Rush University Medical Center

11
Myles C Cabot
Myles C Cabot

John Wayne Cancer Institute at Saint John's Health Center

11
Qian-Jin Zhang
Qian-Jin Zhang

Louisiana State University Health Sciences Center

8
Gauri A Patwardhan
Gauri A Patwardhan

University of Louisiana at Monroe

7
Armando E Giuliano
Armando E Giuliano

John Wayne Cancer Institute at Saint John's Health Center

7
Salman B Hosain
Salman B Hosain

University of Louisiana at Monroe

5
Xin Gu
Xin Gu

Shanghai Tenth People's Hospital

5
Yunfeng Zhao
Yunfeng Zhao

Key Laboratory of Food Safety Risk Assessment

5
Kaustubh N Bhinge
Kaustubh N Bhinge

University of Louisiana at Monroe

4