Yong-Qing Zhou

Yong-Qing Zhou

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Yong-Qing Zhou

Yong-Qing Zhou

Publications by authors named "Yong-Qing Zhou"

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Erratum to: Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer.

J Exp Clin Cancer Res 2016 Jun 17;35(1):95. Epub 2016 Jun 17.

State Key Laboratory for Diagnosis & Treatment of Infectious Diseases and Collaborative Innovation Center for Diagnosis & Treatment of Infectious Diseases, First Hospital of Zhejiang University School of Medicine, Zhejiang, China.

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http://dx.doi.org/10.1186/s13046-016-0364-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912733PMC
June 2016

Biological evaluation of antibody-maytansinoid conjugates as a strategy of RON targeted drug delivery for treatment of non-small cell lung cancer.

J Exp Clin Cancer Res 2016 Apr 22;35:70. Epub 2016 Apr 22.

State Key Laboratory for Diagnosis & Treatment of Infectious Diseases and Collaborative Innovation Center for Diagnosis & Treatment of Infectious Diseases, First Hospital of Zhejiang University School of Medicine, Zhejiang, China.

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http://dx.doi.org/10.1186/s13046-016-0347-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4840490PMC
April 2016

Efficacy of anti-RON antibody Zt/g4-drug maytansinoid conjugation (Anti-RON ADC) as a novel therapeutics for targeted colorectal cancer therapy.

Clin Cancer Res 2014 Dec 7;20(23):6045-58. Epub 2014 Oct 7.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Hospital of Zhejiang University School of Medicine, Zhejiang, China. Department of Biomedical Sciences, Texas Tech University Health Sciences Center School of Pharmacy, Amarillo, Texas.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0898DOI Listing
December 2014

Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics.

Mol Oncol 2014 May 2;8(3):469-82. Epub 2014 Jan 2.

Cancer Biology Research Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA; Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2013.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528636PMC
May 2014

Synergistic activities of MET/RON inhibitor BMS-777607 and mTOR inhibitor AZD8055 to polyploid cells derived from pancreatic cancer and cancer stem cells.

Mol Cancer Ther 2014 Jan 14;13(1):37-48. Epub 2013 Nov 14.

Corresponding Author: M.H. Wang, Department of Biomedical Sciences; School of Pharmacy, Texas Tech University Health Sciences Center, 1406 South Coulter Street, Suite 1117, Amarillo, TX 79106.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0242DOI Listing
January 2014

Expression of dedifferentiation markers and multilineage markers in U251 glioblastoma cells with silenced EGFR and FGFR genes.

Oncol Lett 2014 Jan 18;7(1):131-136. Epub 2013 Nov 18.

Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

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https://www.spandidos-publications.com/10.3892/ol.2013.1685
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http://dx.doi.org/10.3892/ol.2013.1685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861577PMC
January 2014

Pathogenesis of RON receptor tyrosine kinase in cancer cells: activation mechanism, functional crosstalk, and signaling addiction.

J Biomed Res 2013 Sep 30;27(5):345-56. Epub 2013 Jul 30.

Cancer Biology Research Center, ; Department of Biomedical Sciences, and.

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http://dx.doi.org/10.7555/JBR.27.20130038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783819PMC
September 2013

Oncogenic variant RON160 expression in breast cancer and its potential as a therapeutic target by small molecule tyrosine kinase inhibitor.

Curr Cancer Drug Targets 2013 Jul;13(6):686-97

Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1406 S. Coulter Street, Amarillo, TX 79106, USA.

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July 2013

MSP-RON signalling in cancer: pathogenesis and therapeutic potential.

Nat Rev Cancer 2013 Jul;13(7):466-81

Viral Oncogenesis Section in State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P. R. China.

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http://dx.doi.org/10.1038/nrc3545DOI Listing
July 2013

Small-molecule inhibitor BMS-777607 induces breast cancer cell polyploidy with increased resistance to cytotoxic chemotherapy agents.

Mol Cancer Ther 2013 May 6;12(5):725-36. Epub 2013 Mar 6.

Cancer Biology Research Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-12
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http://dx.doi.org/10.1158/1535-7163.MCT-12-1079DOI Listing
May 2013

Surgery for contralateral acute epidural hematoma following acute subdural hematoma evacuation: five new cases and a short literature review.

Acta Neurochir (Wien) 2013 Feb 13;155(2):335-41. Epub 2012 Dec 13.

Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou City, 310003, Zhejiang Province, People's Republic of China.

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http://dx.doi.org/10.1007/s00701-012-1569-9DOI Listing
February 2013

Sustained expression of the RON receptor tyrosine kinase by pancreatic cancer stem cells as a potential targeting moiety for antibody-directed chemotherapeutics.

Mol Pharm 2011 Dec 1;8(6):2310-9. Epub 2011 Nov 1.

School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, United States.

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http://dx.doi.org/10.1021/mp200193uDOI Listing
December 2011

The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells.

Mol Cancer 2011 Jul 12;10:82. Epub 2011 Jul 12.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, Zhejiang 310003, PR China.

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http://dx.doi.org/10.1186/1476-4598-10-82DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3142532PMC
July 2011

Targeting acute hypoxic cancer cells by doxorubicin-immunoliposomes directed by monoclonal antibodies specific to RON receptor tyrosine kinase.

Cancer Chemother Pharmacol 2011 May 25;67(5):1073-83. Epub 2010 Jul 25.

Center for Cancer Biology and Therapeutics, Department of Biomedical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1406 Coulter Street, Suite 1117, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.1007/s00280-010-1408-8DOI Listing
May 2011

Ribosomal protein S6 kinase (RSK)-2 as a central effector molecule in RON receptor tyrosine kinase mediated epithelial to mesenchymal transition induced by macrophage-stimulating protein.

Mol Cancer 2011 May 28;10:66. Epub 2011 May 28.

Division of Cancer Biology at State Key Laboratory for Diagnosis & Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310003, China.

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http://dx.doi.org/10.1186/1476-4598-10-66DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117816PMC
May 2011

[In vitro protective effect of methionine against cisplatin's damage to the cochlear hair cell of mice].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2011 Feb;46(2):128-31

Department of Otorhinolaryngology, Third Affiliated Hospital, Hebei Medical University, Shijiazhuang 050051, China.

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February 2011

Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase.

Mol Cancer 2010 Nov 29;9:307. Epub 2010 Nov 29.

Laboratory of Cancer Biology in State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P, R, China.

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http://dx.doi.org/10.1186/1476-4598-9-307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3001714PMC
November 2010

Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy.

Acta Pharmacol Sin 2010 Sep 9;31(9):1181-8. Epub 2010 Aug 9.

Center for Cancer Biology & Therapeutics, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Amarillo, 79106, USA.

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http://dx.doi.org/10.1038/aps.2010.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002297PMC
September 2010

Monoclonal antibody (mAb)-induced down-regulation of RON receptor tyrosine kinase diminishes tumorigenic activities of colon cancer cells.

Int J Oncol 2010 Aug;37(2):473-82

Department of Biomedical Sciences, Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.3892/ijo_00000696DOI Listing
August 2010

Inhibition of MSP-RON signaling pathway in cancer cells by a novel soluble form of RON comprising the entire sema sequence.

Int J Oncol 2010 Jun;36(6):1551-61

Center for Cancer Biology and Therapeutics, School of Pharmacy, Texas Tech University Health Sciences, Amarillo, TX 79106, USA.

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http://dx.doi.org/10.3892/ijo_00000642DOI Listing
June 2010

[Tympanoplasty using fascia-form molds to shape autogenous temporalis fascia for closing large perforations].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2010 Jun;45(6):506-10

Department of Otorhinolaryngology Head and Neck Surgery, Bethune International Peace Hospital of Chinese People's Liberation Army, Shijiazhuang 050082, China.

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June 2010

Patients with supratentorial aneurysmal subarachnoid hemorrhage during the intermediate period: waiting or actively treating.

Int J Neurosci 2009 ;119(9):1494-506

Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang Province, P.R. China.

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January 2010

Patients with supratentorial aneurysmal subarachnoid hemorrhage during the intermediate period: waiting or actively treating.

Int J Neurosci 2009 ;119(10):1956-67

Department of Neurosurgery, The First Affiliated Hospital, College of Medicine Zhejiang University, Hangzhou, P.R. China.

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January 2010

Alterations in a defined extracellular region of the RON receptor tyrosine kinase promote RON-mediated motile and invasive phenotypes in epithelial cells.

Int J Oncol 2010 Jan;36(1):255-64

Laboratory of Cancer Biology and Therapeutics, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, P.R. China.

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January 2010

Posttransplantation lymphoproliferative disorder involving the central nervous system in liver transplant recipients.

Hepatobiliary Pancreat Dis Int 2008 Oct;7(5):551-4

Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

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October 2008

Treatment of skull base communicating tumor with endoscope-assisted microneurosurgery and diode laser.

Chin Med J (Engl) 2007 Feb;120(4):342-4

Department of Neurosurgery, First Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310003, China.

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February 2007

Can albumin administration relieve lung injury in trauma/hemorrhagic shock?

World J Gastroenterol 2006 Nov;12(42):6884-8

Department of Emergency Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087448PMC
http://dx.doi.org/10.3748/wjg.v12.i42.6884DOI Listing
November 2006

Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers.

Acta Pharmacol Sin 2006 Jun;27(6):641-50

Laboratory of Chang-Kung Scholars Program for Tumor Biology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

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http://dx.doi.org/10.1111/j.1745-7254.2006.00361.xDOI Listing
June 2006

Mechanisms of cytoplasmic {beta}-catenin accumulation and its involvement in tumorigenic activities mediated by oncogenic splicing variant of the receptor originated from Nantes tyrosine kinase.

J Biol Chem 2005 Jul 6;280(26):25087-94. Epub 2005 May 6.

Laboratory of Cheung Kong Scholars Program for Biomedical Sciences at Institute of Infectious Diseases and Division of Neurosurgery, First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, People's Republic of China.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M414699200
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http://dx.doi.org/10.1074/jbc.M414699200DOI Listing
July 2005

Inhibition of NADPH oxidase attenuates vasospasm after experimental subarachnoid hemorrhage in rats.

Stroke 2005 May;36(5):1059-64

Department of Neurosurgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.1161/01.STR.0000163102.49888.b7DOI Listing
May 2005

Delayed gene therapy of glial cell line-derived neurotrophic factor is efficacious in a rat model of Parkinson's disease.

Brain Res Mol Brain Res 2005 Mar;134(1):155-61

Department of Neurosurgery, the First Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310003, China.

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http://dx.doi.org/10.1016/j.molbrainres.2004.06.029DOI Listing
March 2005

[Clinical analysis of 71 cases of multiple primary cancers in head and neck squamous carcinomas].

Zhonghua Er Bi Yan Hou Ke Za Zhi 2004 Apr;39(4):232-6

Department of Otorhinolaryngology Head & Neck Surgery, PLA Center for Otorhinolaryngological Diseases, Bethune International Peace Hospital of PLA, Shijiazhuang 050082, China.

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April 2004

[Analysis of risk factors in the prediction of distant metastases of head and neck squamous cell carcinomas].

Zhonghua Er Bi Yan Hou Ke Za Zhi 2004 Mar;39(3):171-5

Department of Otorhinolaryngology Head & Neck Surgery, PLA Center for Otorhinolaryngological Diseases, Bethune International Peace Hospital, Shijiazhuang 050082, China.

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March 2004

Prevalence of dementia in China.

Dement Geriatr Cogn Disord 2003 ;15(4):226-30

Department of Clinical Sciences, Fourth Military Medical University, Xi'an, China.

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http://dx.doi.org/10.1159/000068784DOI Listing
July 2003

Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential.

Oncogene 2003 Jan;22(2):186-97

Division of Neurosurgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

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http://dx.doi.org/10.1038/sj.onc.1206075DOI Listing
January 2003

Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais.

Carcinogenesis 2002 Nov;23(11):1811-9

Department of Medicine, University of Colorado School of Medicine, CU Cancer Center, and Denver Health Medical Center, Denver, CO 80204, USA.

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http://dx.doi.org/10.1093/carcin/23.11.1811DOI Listing
November 2002

Activation of the RON receptor tyrosine kinase by macrophage-stimulating protein inhibits inducible cyclooxygenase-2 expression in murine macrophages.

J Biol Chem 2002 Oct 12;277(41):38104-10. Epub 2002 Aug 12.

Division of Neurosurgery, The First Affiliated Teaching Hospital, Zhejiang University School of Medicine, Hangzhou 310003, People's Republic of China.

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http://dx.doi.org/10.1074/jbc.M206167200DOI Listing
October 2002

Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo.

Oncogene 2002 Sep;21(41):6382-6

Division of Pulmonary Sciences and Critical Care, Department of Medicine, University of Colorado School of Medicine, CU Cancer Center, and Denver Health Medical Center, Denver, Colorado, CO 80204, USA.

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http://dx.doi.org/10.1038/sj.onc.1205783DOI Listing
September 2002

Activation of the RON receptor tyrosine kinase protects murine macrophages from apoptotic death induced by bacterial lipopolysaccharide.

J Leukoc Biol 2002 Feb;71(2):359-66

Department of Medicine, University of Colorado School of Medicine, Denver Health Medical Center, 80204, USA.

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February 2002