Publications by authors named "Yong-Mahn Han"

92Publications

Tris(2-carboxyethyl)phosphine-Mediated Nanometric Extracellular Matrix-Coating Method of Mesenchymal Stem Cells.

Authors:
IlKyoo Koh Insung Yong Bumsoo Kim Daheui Choi Jinkee Hong Yong-Mahn Han Pilnam Kim

ACS Biomater Sci Eng 2020 Feb 13;6(2):813-821. Epub 2020 Jan 13.

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.

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February 2020

Association between ARID2 and RAS-MAPK pathway in intellectual disability and short stature.

Authors:
Eungu Kang Minji Kang Younghee Ju Sang-Joon Lee Yong-Seok Lee Dong-Cheol Woo Young Hoon Sung In-Jeoung Baek Woo Hyun Shim Woo-Chan Son In Hee Choi Eul-Ju Seo Han-Wook Yoo Yong-Mahn Han Beom Hee Lee

J Med Genet 2020 Oct 13. Epub 2020 Oct 13.

Medical Genetics Center, Asan Medical Center, Seoul, Republic of Korea

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October 2020

Correction to: SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro.

Authors:
Younghee Ju Jun Sung Park Daejeong Kim Bumsoo Kim Jeong Ho Lee Yoonkey Nam Han-Wook Yoo Beom Hee Lee Yong-Mahn Han

Stem Cell Res Ther 2020 Jul 16;11(1):282. Epub 2020 Jul 16.

Department of Biological Sciences, KAIST, Daejeon, 34141, Republic of Korea.

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July 2020

SHP2 mutations induce precocious gliogenesis of Noonan syndrome-derived iPSCs during neural development in vitro.

Authors:
Younghee Ju Jun Sung Park Daejeong Kim Bumsoo Kim Jeong Ho Lee Yoonkey Nam Han-Wook Yoo Beom Hee Lee Yong-Mahn Han

Stem Cell Res Ther 2020 06 3;11(1):209. Epub 2020 Jun 3.

Department of Biological Sciences, KAIST, Daejeon, 34141, Republic of Korea.

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June 2020

Enhanced thrombospondin-1 causes dysfunction of vascular endothelial cells derived from Fabry disease-induced pluripotent stem cells.

Authors:
Hyo-Sang Do Sang-Wook Park Ilkyun Im Donghyuk Seo Han-Wook Yoo Heounjeong Go Yoo Hyung Kim Gou Young Koh Beom-Hee Lee Yong-Mahn Han

EBioMedicine 2020 Feb 23;52:102633. Epub 2020 Jan 23.

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea. Electronic address:

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February 2020

Impaired Osteogenesis of Disease-Specific Induced Pluripotent Stem Cells Derived from a CFC Syndrome Patient.

Authors:
Jung-Yun Choi Kyu-Min Han Dongkyu Kim Beom-Hee Lee Han-Wook Yoo Jin-Ho Choi Yong-Mahn Han

Int J Mol Sci 2017 Dec 1;18(12). Epub 2017 Dec 1.

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.

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December 2017

Prediction of drug-induced immune-mediated hepatotoxicity using hepatocyte-like cells derived from human embryonic stem cells.

Authors:
Dong Eon Kim Mi-Jin Jang Young Ran Kim Joo-Young Lee Eun Byul Cho Eunha Kim Yeji Kim Mi Young Kim Won-Il Jeong Seyun Kim Yong-Mahn Han Seung-Hyo Lee

Toxicology 2017 07 20;387:1-9. Epub 2017 Jun 20.

Biomedical Science and Engineering Interdisciplinary Program, Daejeon, 34141, South Korea; Graduate School of Medical Science and Engineering, Biomedical Research Center, Daejeon, 34141, South Korea. Electronic address:

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July 2017

Lineage-specific Expression of miR-200 Family in Human Embryonic Stem Cells during In Vitro Differentiation.

Authors:
Yeji Kim Nury Kim Sang-Wook Park Hyemin Kim Han-Jin Park Yong-Mahn Han

Int J Stem Cells 2017 May;10(1):28-37

Department of Biological Sciences and Center for Stem Cell Differentiation, KAIST, Daejeon, Korea.

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May 2017

Generation of PDGFRα Cardioblasts from Pluripotent Stem Cells.

Authors:
Seon Pyo Hong Sukhyun Song Sung Woo Cho Seungjoo Lee Bong Ihn Koh Hosung Bae Kyun Hoo Kim Jin-Sung Park Hyo-Sang Do Ilkyun Im Hye Jin Heo Tae Hee Ko Jae-Hyeong Park Jae Boum Youm Seong-Jin Kim Injune Kim Jin Han Yong-Mahn Han Gou Young Koh

Sci Rep 2017 02 6;7:41840. Epub 2017 Feb 6.

Biomedical Science and Engineering Interdisciplinary Program, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.

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February 2017

Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo.

Authors:
Youngjin Kim Hyeongseok Kim Ung Hyun Ko Youjin Oh Ajin Lim Jong-Woo Sohn Jennifer H Shin Hail Kim Yong-Mahn Han

Sci Rep 2016 10 12;6:35145. Epub 2016 Oct 12.

Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.

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October 2016

Exosome-mediated activation of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by γδ T cells in liver fibrosis.

Authors:
Wonhyo Seo Hyuk Soo Eun So Yeon Kim Hyon-Seung Yi Young-Sun Lee Seol-Hee Park Mi-Jin Jang Eunjung Jo Sun Chang Kim Yong-Mahn Han Keun-Gyu Park Won-Il Jeong

Hepatology 2016 08 29;64(2):616-31. Epub 2016 Jun 29.

Laboratory of Liver Research, Biomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, Republic of Korea.

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August 2016

Malfunction in Mitochondrial β-Oxidation Contributes to Lipid Accumulation in Hepatocyte-Like Cells Derived from Citrin Deficiency-Induced Pluripotent Stem Cells.

Authors:
Yeji Kim Jung-Yun Choi Sang-Hee Lee Beom-Hee Lee Han-Wook Yoo Yong-Mahn Han

Stem Cells Dev 2016 Apr 30;25(8):636-47. Epub 2016 Mar 30.

1 Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.

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April 2016

Xeno-sensing activity of the aryl hydrocarbon receptor in human pluripotent stem cell-derived hepatocyte-like cells.

Authors:
Hye-Min Kim Ji-Woo Kim Youngjun Choi Hang-Suk Chun Ilkyun Im Yong-Mahn Han Chang-Woo Song Seokjoo Yoon Han-Jin Park

Sci Rep 2016 Feb 22;6:21684. Epub 2016 Feb 22.

Alternative Toxicological Methods Research Center, Korea Institute of Toxicology, Daejeon 34114, Republic of Korea.

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February 2016

Long-term, feeder-free maintenance of human embryonic stem cells by mussel-inspired adhesive heparin and collagen type I.

Authors:
Mihyun Lee Youngjin Kim Ji Hyun Ryu Kyuri Kim Yong-Mahn Han Haeshin Lee

Acta Biomater 2016 Mar 7;32:138-148. Epub 2016 Jan 7.

Department of Chemistry, KAIST, 291 University Rd., Yuseong-gu, Daejeon 305-701, Republic of Korea. Electronic address:

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March 2016

Mitochondrial Respiratory Defect Causes Dysfunctional Lactate Turnover via AMP-activated Protein Kinase Activation in Human-induced Pluripotent Stem Cell-derived Hepatocytes.

Authors:
Ilkyun Im Mi-Jin Jang Seung Ju Park Sang-Hee Lee Jin-Ho Choi Han-Wook Yoo Seyun Kim Yong-Mahn Han

J Biol Chem 2015 Dec 21;290(49):29493-505. Epub 2015 Oct 21.

From the Department of Biological Sciences, Center for Stem Cell Differentiation, and

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December 2015

Optogenetic control of endogenous Ca(2+) channels in vivo.

Authors:
Taeyoon Kyung Sangkyu Lee Jung Eun Kim Taesup Cho Hyerim Park Yun-Mi Jeong Dongkyu Kim Anna Shin Sungsoo Kim Jinhee Baek Jihoon Kim Na Yeon Kim Doyeon Woo Sujin Chae Cheol-Hee Kim Hee-Sup Shin Yong-Mahn Han Daesoo Kim Won Do Heo

Nat Biotechnol 2015 Oct 14;33(10):1092-6. Epub 2015 Sep 14.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.

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October 2015

Impaired osteogenesis in Menkes disease-derived induced pluripotent stem cells.

Authors:
Dongkyu Kim Jieun Choi Kyu-Min Han Beom Hee Lee Jin-Ho Choi Han-Wook Yoo Yong-Mahn Han

Stem Cell Res Ther 2015 Sep 7;6:160. Epub 2015 Sep 7.

Department of Biological Science, Korea Advanced Institute of Science Technology (KAIST), Daejeon, 305-701, Republic of Korea.

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September 2015

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.

Authors:
Han-Jin Park Young-Jun Choi Ji Woo Kim Hang-Suk Chun Ilkyun Im Seokjoo Yoon Yong-Mahn Han Chang-Woo Song Hyemin Kim

PLoS One 2015 15;10(7):e0132992. Epub 2015 Jul 15.

Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305-343, Republic of Korea.

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April 2016

Enhanced SMAD1 Signaling Contributes to Impairments of Early Development in CFC-iPSCs.

Authors:
Kyu-Min Han Seung-Kyoon Kim Dongkyu Kim Jung-Yun Choi Ilkyun Im Kyu-Seok Hwang Cheol-Hee Kim Beom Hee Lee Han-Wook Yoo Yong-Mahn Han

Stem Cells 2015 May;33(5):1447-55

Department of Biological Sciences and Center for Stem Cell Differentiation, KAIST, Daejeon, Republic of Korea.

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May 2015

SET7/9 methylation of the pluripotency factor LIN28A is a nucleolar localization mechanism that blocks let-7 biogenesis in human ESCs.

Authors:
Seung-Kyoon Kim Hosuk Lee Kyumin Han Sang Cheol Kim Yoonjung Choi Sang-Wook Park Geunu Bak Younghoon Lee Jung Kyoon Choi Tae-Kyung Kim Yong-Mahn Han Daeyoup Lee

Cell Stem Cell 2014 Dec;15(6):735-49

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea. Electronic address:

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December 2014

Transcriptional Profiles of Imprinted Genes in Human Embryonic Stem Cells During In vitro Differentiation.

Authors:
Sang-Wook Park Hyo-Sang Do Dongkyu Kim Ji-Yun Ko Sang-Hun Lee Yong-Mahn Han

Int J Stem Cells 2014 Nov;7(2):108-17

Department of Biological Sciences and Center for Stem Cell Differentiation, Korea Advanced Institute of Science and Technology (KAIST), Daejeon.

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November 2014

DUSP4 regulates neuronal differentiation and calcium homeostasis by modulating ERK1/2 phosphorylation.

Authors:
Sun Young Kim Yong-Mahn Han Mihee Oh Won-Kon Kim Kyoung-Jin Oh Sang Chul Lee Kwang-Hee Bae Baek-Soo Han

Stem Cells Dev 2015 Mar 23;24(6):686-700. Epub 2014 Dec 23.

1 Department of Biological Sciences, Center for Stem Cell Differentiation, KAIST , Daejeon, Republic of Korea.

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March 2015

Generation of bladder urothelium from human pluripotent stem cells under chemically defined serum- and feeder-free system.

Authors:
Minyong Kang Hyeon Hoe Kim Yong-Mahn Han

Int J Mol Sci 2014 Apr 25;15(5):7139-57. Epub 2014 Apr 25.

Graduate School of Medical Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Korea.

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April 2014

Differentiation of human pluripotent stem cells into nephron progenitor cells in a serum and feeder free system.

Authors:
Minyong Kang Yong-Mahn Han

PLoS One 2014 11;9(4):e94888. Epub 2014 Apr 11.

Graduate Schools of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea; Department of Biological Sciences, KAIST, Daejeon, Republic of Korea.

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May 2015

Dual modulation of the mitochondrial permeability transition pore and redox signaling synergistically promotes cardiomyocyte differentiation from pluripotent stem cells.

Authors:
Sung Woo Cho Jin-Sung Park Hye Jin Heo Sang-Wook Park Sukhyun Song Injune Kim Yong-Mahn Han Jun K Yamashita Jae Boum Youm Jin Han Gou Young Koh

J Am Heart Assoc 2014 Mar 13;3(2):e000693. Epub 2014 Mar 13.

Laboratory of Vascular Biology and Stem Cell, Korea Advanced Institute of Science and Technology.

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March 2014

Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro.

Authors:
Sang-Wook Park Jihoon Kim Jong-Lyul Park Ji-Yun Ko Ilkyun Im Hyo-Sang Do Hyemin Kim Ngoc-Tung Tran Sang-Hun Lee Yong Sung Kim Yee Sook Cho Dong Ryul Lee Yong-Mahn Han

Biochem Biophys Res Commun 2014 Apr 12;446(2):493-8. Epub 2014 Mar 12.

Department of Biological Sciences and Center for Stem Cell Differentiation, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea. Electronic address:

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April 2014

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy.

Authors:
Chul-Su Yang Jwa-Jin Kim Hye-Mi Lee Hyo Sun Jin Sang-Hee Lee Ji-Hoon Park Soung Jung Kim Jin-Man Kim Yong-Mahn Han Myung-Shik Lee Gi Ryang Kweon Minho Shong Eun-Kyeong Jo

Autophagy 2014 May 25;10(5):785-802. Epub 2014 Feb 25.

Department of Microbiology; Chungnam National University School of Medicine; Daejeon, Korea; Infection Signaling Network Research Center; Chungnam National University School of Medicine; Daejeon, Korea.

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May 2014

Modeling of Menkes disease via human induced pluripotent stem cells.

Authors:
Ji-Hoon Suh Dongkyu Kim Hyemin Kim David M Helfman Jin-Ho Choi Beom Hee Lee Han-Wook Yoo Yong-Mahn Han

Biochem Biophys Res Commun 2014 Feb 24;444(3):311-8. Epub 2014 Jan 24.

Graduate Schools of Medical Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea; Department of Biological Sciences, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon 305-701, Republic of Korea. Electronic address:

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February 2014

The reprogramming factor nuclear receptor subfamily 5, group A, member 2 cannot replace octamer-binding transcription factor 4 function in the self-renewal of embryonic stem cells.

Authors:
Kyeng-Won Choi Hye-Rim Oh Jaeyoung Lee Bobae Lim Yong-Mahn Han Junseo Oh Jungho Kim

FEBS J 2014 Feb 16;281(4):1029-45. Epub 2013 Dec 16.

Department of Life Science, Laboratory of Molecular and Cellular Biology, Sogang University, Seoul, Korea.

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February 2014

Comparative receptor tyrosine kinase profiling identifies a novel role for AXL in human stem cell pluripotency.

Authors:
Mi-Young Son Binna Seol Yong-Mahn Han Yee Sook Cho

Hum Mol Genet 2014 Apr 11;23(7):1802-16. Epub 2013 Nov 11.

Stem Cell Research Center, KRIBB, 125 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea.

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April 2014

Autophagy regulates homeostasis of pluripotency-associated proteins in hESCs.

Authors:
Yun-Hee Cho Kyu-Min Han Dongkyu Kim Joonsun Lee Sang-Hee Lee Kyeng-Won Choi Jungho Kim Yong-Mahn Han

Stem Cells 2014 Feb;32(2):424-35

Department of Biological Sciences and Center for Stem Cell Differentiation, Daejeon, Republic of Korea.

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February 2014

Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency.

Authors:
Mi-Young Son Hoonsung Choi Yong-Mahn Han Yee Sook Cho

Stem Cells 2013 Nov;31(11):2374-87

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea; Stem Cell Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.

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November 2013

Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway.

Authors:
Kyung-Soon Park Young Cha Chun-Hyung Kim Hee-Jin Ahn Dohoon Kim Sanghyeok Ko Kyeoung-Hwa Kim Mi-Yoon Chang Jong-Hyun Ko Yoo-Sun Noh Yong-Mahn Han Jonghwan Kim Jihwan Song Jin Young Kim Paul J Tesar Robert Lanza Kyung-Ah Lee Kwang-Soo Kim

Stem Cells 2013 Feb;31(2):282-92

Department of Biomedical Science, College of Life Science, CHA University, Seoul, Korea.

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February 2013

Human histone H3K79 methyltransferase DOT1L protein [corrected] binds actively transcribing RNA polymerase II to regulate gene expression.

Authors:
Seung-Kyoon Kim Inkyung Jung Hosuk Lee Keunsoo Kang Mirang Kim Kwiwan Jeong Chang Seob Kwon Yong-Mahn Han Yong Sung Kim Dongsup Kim Daeyoup Lee

J Biol Chem 2012 Nov 25;287(47):39698-709. Epub 2012 Sep 25.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.

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November 2012

Variations in the epigenetic regulation of lineage-specific genes among human pluripotent stem cell lines.

Authors:
Hyemin Kim Dongkyu Kim Mi-Jin Jang Yong-Mahn Han

Biochem Biophys Res Commun 2012 Jul 2;424(2):331-7. Epub 2012 Jul 2.

Department of Biological Sciences and Center for Stem Cell Differentiation, KAIST, Daejeon 305-701, Republic of Korea.

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July 2012

H2B monoubiquitylation is a 5'-enriched active transcription mark and correlates with exon-intron structure in human cells.

Authors:
Inkyung Jung Seung-Kyoon Kim Mirang Kim Yong-Mahn Han Yong Sung Kim Dongsup Kim Daeyoup Lee

Genome Res 2012 Jun 15;22(6):1026-35. Epub 2012 Mar 15.

Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Yuseong-gu, Daejeon, Korea;

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June 2012

Generation of human induced pluripotent stem cells from osteoarthritis patient-derived synovial cells.

Authors:
Min-Jeong Kim Myung Jin Son Mi-Young Son Binna Seol Janghwan Kim Jongjin Park Jung Hwa Kim Yong-Hoon Kim Su A Park Chul-Ho Lee Kang-Sik Lee Yong-Mahn Han Jae-Suk Chang Yee Sook Cho

Arthritis Rheum 2011 Oct;63(10):3010-21

Korea Research Institute of Bioscience and Biotechnology and University of Science and Technology, Daejeon, Republic of Korea.

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October 2011

Prolonged membrane depolarization enhances midbrain dopamine neuron differentiation via epigenetic histone modifications.

Authors:
Xi-Biao He Sang-Hoon Yi Yong-Hee Rhee Hyemin Kim Yong-Mahn Han Suk-Ho Lee Hyunsu Lee Chang-Hwan Park Yong-Sung Lee Eric Richardson Byung-Woo Kim Sang-Hun Lee

Stem Cells 2011 Nov;29(11):1861-73

Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seoul, Korea.

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November 2011

The effects of the physical properties of culture substrates on the growth and differentiation of human embryonic stem cells.

Authors:
Sunray Lee Jihoon Kim Tae Jung Park Youngmin Shin Sang Yup Lee Yong-Mahn Han Seongman Kang Hyun-Sook Park

Biomaterials 2011 Dec 10;32(34):8816-29. Epub 2011 Sep 10.

Stem Cell Niche Division, Research Institute, Modern Cell and Tissue Technologies (MCTT) Inc., Seoul TechnoPark, Seoul, Republic of Korea.

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December 2011

Efficient differentiation of human pluripotent stem cells into mesenchymal stem cells by modulating intracellular signaling pathways in a feeder/serum-free system.

Authors:
Ngoc-Tung Tran Quynh-Mai Trinh Gyun Min Lee Yong-Mahn Han

Stem Cells Dev 2012 May 27;21(7):1165-75. Epub 2011 Sep 27.

Department of Biological Sciences and Center for Stem Cell Differentiation, KAIST (Korean Advance Institute of Sciences and Technology), Yuseong-gu, Daejeon, Republic of Korea.

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May 2012

Comparative proteomic analysis of human somatic cells, induced pluripotent stem cells, and embryonic stem cells.

Authors:
Sun Young Kim Min-Jeong Kim Hyeyun Jung Won Kon Kim Sang Oh Kwon Myung Jin Son Ik-Soon Jang Jong-Soon Choi Sung Goo Park Byoung Chul Park Yong-Mahn Han Sang Chul Lee Yee Sook Cho Kwang-Hee Bae

Stem Cells Dev 2012 May 29;21(8):1272-86. Epub 2011 Aug 29.

Medical Proteomics Research Center, KRIBB, Daejeon, South Korea.

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May 2012

Angiopoietin-1 promotes endothelial differentiation from embryonic stem cells and induced pluripotent stem cells.

Authors:
Hyung Joon Joo Honsoul Kim Sang-Wook Park Hyun-Jai Cho Hyo-Soo Kim Do-Sun Lim Hyung-Min Chung Injune Kim Yong-Mahn Han Gou Young Koh

Blood 2011 Aug 16;118(8):2094-104. Epub 2011 Jun 16.

Laboratory for Vascular Biology and Stem Cell, Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.

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August 2011

Identification of DNA methylation markers for lineage commitment of in vitro hepatogenesis.

Authors:
Mirang Kim Tae-Wook Kang Han-Chul Lee Yong-Mahn Han Hyemin Kim Hyoung Doo Shin Hyun Sub Cheong Daeyoup Lee Seon-Young Kim Yong Sung Kim

Hum Mol Genet 2011 Jul 19;20(14):2722-33. Epub 2011 Apr 19.

1Medical Genomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.

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July 2011

Expression profiles of miRNAs in human embryonic stem cells during hepatocyte differentiation.

Authors:
Nury Kim Hyemin Kim Inkyung Jung Yeji Kim Dongsup Kim Yong-Mahn Han

Hepatol Res 2011 Feb;41(2):170-83

Department of Biological Sciences and Center for Stem Cell Differentiation Department of Bio and Brain Engineering, Daejeon, Korea.

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February 2011

Combinatorial activin receptor-like kinase/Smad and basic fibroblast growth factor signals stimulate the differentiation of human embryonic stem cells into the cardiac lineage.

Authors:
Jin-Yong Yook Min-Jeong Kim Myung Jin Son Seokyoung Lee Yoonkey Nam Yong-Mahn Han Yee Sook Cho

Stem Cells Dev 2011 Sep 17;20(9):1479-90. Epub 2011 Feb 17.

Development and Differentiation Research Center, KRIBB, Daejeon, Republic of Korea.

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September 2011

Epigenetic modification of retinoic acid-treated human embryonic stem cells.

Authors:
Hyun Sub Cheong Han Chul Lee Byung Lae Park Hyemin Kim Mi Jin Jang Yong Mahn Han Seun-Young Kim Yong Sung Kim Hyoung Doo Shin

BMB Rep 2010 Dec;43(12):830-5

Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul 153-803, Korea.

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December 2010

Epigenetic signatures and temporal expression of lineage-specific genes in hESCs during differentiation to hepatocytes in vitro.

Authors:
Hyemin Kim Mi-Jin Jang Man-Jong Kang Yong-Mahn Han

Hum Mol Genet 2011 Feb 8;20(3):401-12. Epub 2010 Nov 8.

Department of Biological Sciences and Center for Stem Cell Differentiation, KAIST, Daejeon 305-701, Republic of Korea.

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February 2011

Efficient differentiation of human pluripotent stem cells into functional CD34+ progenitor cells by combined modulation of the MEK/ERK and BMP4 signaling pathways.

Authors:
Sang-Wook Park Young Jun Koh Jongwook Jeon Yun-Hee Cho Mi-Jin Jang Yujung Kang Min-Jeong Kim Chulhee Choi Yee Sook Cho Hyung-Min Chung Gou Young Koh Yong-Mahn Han

Blood 2010 Dec 30;116(25):5762-72. Epub 2010 Sep 30.

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.

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December 2010

Identification of an intermediate state as spermatogonial stem cells reprogram to multipotent cells.

Authors:
Hyung Joon Kim Hyun Jung Lee Jung Jin Lim Ki Hoon Kwak Jong Soo Kim Ji Hoon Kim Yong-Mahn Han Kye-Seong Kim Dong Ryul Lee

Mol Cells 2010 May 12;29(5):519-26. Epub 2010 Apr 12.

Fertility Center of CHA Gangnam Medical Center, College of Medicine, CHA University, Seoul, 135-081, Korea.

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May 2010

Oct-4 controls cell-cycle progression of embryonic stem cells.

Authors:
Jungwoon Lee Yeorim Go Inyoung Kang Yong-Mahn Han Jungho Kim

Biochem J 2010 Feb 9;426(2):171-81. Epub 2010 Feb 9.

Laboratory of Molecular and Cellular Biology, Department of Life Science, Sogang University, Seoul 121-742, Republic of Korea.

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February 2010

Functional recapitulation of smooth muscle cells via induced pluripotent stem cells from human aortic smooth muscle cells.

Authors:
Tae-Hee Lee Sun-Hwa Song Koung Li Kim Ji-Yeun Yi Ga-Hee Shin Ji Yeon Kim Jihoon Kim Yong-Mahn Han Sang Hun Lee Suk-Ho Lee Sung Han Shim Wonhee Suh

Circ Res 2010 Jan 3;106(1):120-8. Epub 2009 Dec 3.

Department of Molecular and Life Science, CHA Stem Cell Institute, Pochon CHA University, Seoul, Korea.

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January 2010

Behaviors of ATP-dependent chromatin remodeling factors during maturation of bovine oocytes in vitro.

Authors:
Gabbine Wee Sang-Tae Shin Deog-Bon Koo Yong-Mahn Han

Mol Reprod Dev 2010 Feb;77(2):126-35

Department of Biological Sciences, Center for Stem Cell Differentiation, KAIST, Daejeon, Republic of Korea.

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February 2010

A microfluidic in vitro cultivation system for mechanical stimulation of bovine embryos.

Authors:
Minseok S Kim Chae Yun Bae Gabbine Wee Yong-Mahn Han Je-Kyun Park

Electrophoresis 2009 Sep;30(18):3276-82

Department of Bio and Brain Engineering, KAIST, Yuseong-gu, Daejeon, Korea.

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September 2009

Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells.

Authors:
Sun-Mi Woo Janghwan Kim Hyo-Won Han Jung-Il Chae Mi-Young Son Sunwha Cho Hyung-Min Chung Yong-Mahn Han Yong-Kook Kang

BMC Neurosci 2009 Aug 17;10:97. Epub 2009 Aug 17.

Development and Differentiation Research Center, KRIBB, 111 Gwahangno, Yuseong-gu, Daejeon 305-806, South Korea.

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August 2009

Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway.

Authors:
Kyu-Won Lee Jin-Yong Yook Mi-Young Son Min-Jeong Kim Deog-Bon Koo Yong-Mahn Han Yee Sook Cho

Stem Cells Dev 2010 Apr;19(4):557-68

Development and Differentiation Research Center, KRIBB, Daejeon, Republic of Korea.

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April 2010

Nucleologenesis and embryonic genome activation are defective in interspecies cloned embryos between bovine ooplasm and rhesus monkey somatic cells.

Authors:
Bong-Seok Song Sang-Hee Lee Sun-Uk Kim Ji-Su Kim Jung Sun Park Cheol-Hee Kim Kyu-Tae Chang Yong-Mahn Han Kyung-Kwang Lee Dong-Seok Lee Deog-Bon Koo

BMC Dev Biol 2009 Jul 28;9:44. Epub 2009 Jul 28.

Development and Differentiation Research Center, Korea Research Institute of Bioscience and Biotechnology, Gwahangno, Yuseong-gu, Daejeon, Republic of Korea.

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July 2009

Prostacyclin stimulates embryonic development via regulation of the cAMP response element-binding protein-cyclo-oxygenase-2 signalling pathway in cattle.

Authors:
Bong-Seok Song Ji-Su Kim Cheol-Hee Kim Yong-Mahn Han Dong-Seok Lee Kyung-Kwang Lee Deog-Bon Koo

Reprod Fertil Dev 2009 ;21(3):400-7

Center for Regenerative Medicine, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 111 Gwahangno, Yuseong, Daejeon 305-806, Korea.

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May 2009

Mutation in the DNA-binding domain of the EWS-Oct-4 oncogene results in dominant negative activity that interferes with EWS-Oct-4-mediated transactivation.

Authors:
Sol Kim Jungwoon Lee Ja Young Kim Bobae Lim Eung-Kyun Shin Yong-Mahn Han Sung-Su Kim Jin-Ho Song Jungho Kim

Int J Cancer 2009 May;124(10):2312-22

Laboratory of Molecular and Cellular Biology, Department of Life Science, Sogang University, Seoul, Korea.

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May 2009

Expression profiles of protein tyrosine kinase genes in human embryonic stem cells.

Authors:
Mi-Young Son Janghwan Kim Hyo-Won Han Sun-Mi Woo Yee Sook Cho Yong-Kook Kang Yong-Mahn Han

Reproduction 2008 Oct 26;136(4):423-32. Epub 2008 Jun 26.

Korea Research Institute of Bioscience and Biotechnology (KRIBB), Center for Regenerative Medicine, Yuseong-Gu, Daejeon 305-806, South Korea.

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October 2008

Aberrant expression of developmentally important signaling molecules in cloned porcine extraembryonic tissues.

Authors:
Jung-Il Chae Kweon Yu Seong-Keun Cho Jin-Hoi Kim Deog-Bon Koo Kyung-Kwang Lee Yong-Mahn Han

Proteomics 2008 Jul;8(13):2724-34

Center for Regenerative Medicine, KRIBB, Daejeon, Korea.

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July 2008

Crif1 is a novel transcriptional coactivator of STAT3.

Authors:
Min-chul Kwon Bon-Kyoung Koo Jin-Sook Moon Yoon-Young Kim Ki Cheol Park Nam-Shik Kim Mi Yi Kwon Myung-Phil Kong Ki-Jun Yoon Sun-Kyoung Im Jaewang Ghim Yong-Mahn Han Sung Key Jang Minho Shong Young-Yun Kong

EMBO J 2008 Feb 17;27(4):642-53. Epub 2008 Jan 17.

Department of Life Science, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, South Korea.

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February 2008

Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription.

Authors:
Jungwoon Lee Hye Kyoung Kim Yong-Mahn Han Jungho Kim

Int J Biochem Cell Biol 2008 29;40(5):1043-54. Epub 2007 Nov 29.

Department of Life Science, Sogang University, Seoul 121-742, Republic of Korea.

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June 2008

Proteomic analysis of pancreas derived from adult cloned pig.

Authors:
Jung-Il Chae Young Keun Cho Seong-Keun Cho Jin-Hoi Kim Yong-Mahn Han Deog-Bon Koo Kyung-Kwang Lee

Biochem Biophys Res Commun 2008 Feb 3;366(2):379-87. Epub 2007 Dec 3.

Centre for Regenerative Medicine, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea.

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February 2008

Subsets of cloned mouse embryos and their non-random relationship to development and nuclear reprogramming.

Authors:
Fatima M Cavaleri Sebastian T Balbach Luca Gentile Anna Jauch Barbara Böhm-Steuer Yong-Mahn Han Hans R Schöler Michele Boiani

Mech Dev 2008 Jan-Feb;125(1-2):153-66. Epub 2007 Sep 29.

Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, Münster, Germany.

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April 2008

Epigenetic alteration of the donor cells does not recapitulate the reprogramming of DNA methylation in cloned embryos.

Authors:
Gabbine Wee Jung-Jae Shim Deog-Bon Koo Jung-Il Chae Kyung-Kwang Lee Yong-Mahn Han

Reproduction 2007 Dec;134(6):781-7

Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea.

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December 2007

REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation.

Authors:
So Yun Park Jae Bum Kim Yong-Mahn Han

J Neurochem 2007 Dec;103(6):2565-74

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.

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December 2007

Chromosome stability differs in cloned mouse embryos and derivative ES cells.

Authors:
Sebastian T Balbach Anna Jauch Barbara Böhm-Steuer Fatima M Cavaleri Yong-Mahn Han Michele Boiani

Dev Biol 2007 Aug 2;308(2):309-21. Epub 2007 Jun 2.

Max Planck Institute for Molecular Biomedicine, Röntgenstrasse 20, D-48149 Münster, Germany.

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August 2007

The EWS-Oct-4 fusion gene encodes a transforming gene.

Authors:
Jungwoon Lee Ja Young Kim In Young Kang Hye Kyoung Kim Yong-Mahn Han Jungho Kim

Biochem J 2007 Sep;406(3):519-26

Laboratory of Molecular and Cellular Biology, Department of Life Science, Sogang University, Seoul 121-742, South Korea.

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September 2007

Characterization of DNA methylation change in stem cell marker genes during differentiation of human embryonic stem cells.

Authors:
Seungeun Yeo Sangkyun Jeong Janghwan Kim Jee-Soo Han Yong-Mahn Han Yong-Kook Kang

Biochem Biophys Res Commun 2007 Aug 25;359(3):536-42. Epub 2007 May 25.

Center for Regenerative Medicine, KRIBB, Eoeun-Dong, Yuseong-Gu, Daejeon 305-333, Republic of Korea.

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August 2007

Simvastatin suppresses self-renewal of mouse embryonic stem cells by inhibiting RhoA geranylgeranylation.

Authors:
Mi-Hee Lee Yee Sook Cho Yong-Mahn Han

Stem Cells 2007 Jul 26;25(7):1654-63. Epub 2007 Apr 26.

Center for Development & Differentiation, KRIBB, Yuseong-gu, Daejeon 305-701, Republic of Korea.

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July 2007

Microfabricated embryonic stem cell divider for large-scale propagation of human embryonic stem cells.

Authors:
Minseok S Kim Janghwan Kim Hyo-Won Han Yee Sook Cho Yong-Mahn Han Je-Kyun Park

Lab Chip 2007 Apr 4;7(4):513-5. Epub 2007 Jan 4.

Department of BioSystems, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon 305-701, Republic of Korea.

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April 2007

Cyclopamine treatment of human embryonic stem cells followed by culture in human astrocyte medium promotes differentiation into nestin- and GFAP-expressing astrocytic lineage.

Authors:
Dong-Seok Lee Kweon Yu Jeung-Yon Rho Eunyoung Lee Jee-Soo Han Deog-Bon Koo Yee Sook Cho Janghwan Kim Kyung-Kwang Lee Yong-Mahn Han

Life Sci 2006 Dec 23;80(2):154-9. Epub 2006 Sep 23.

Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, Daejeon 300-303, Republic of Korea.

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December 2006

Role of cytosolic malate dehydrogenase in oocyte maturation and embryo development.

Authors:
Se-Jin Yoon Deog-Bon Koo Jung Sun Park Kyung-Hee Choi Yong-Mahn Han Kyung-Ah Lee

Fertil Steril 2006 Oct 7;86(4 Suppl):1129-36. Epub 2006 Sep 7.

CHA Research Institute, Fertility Center, CHA General Hospital, Seoul, Korea.

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October 2006

The human OCT-4 isoforms differ in their ability to confer self-renewal.

Authors:
Jungwoon Lee Hye Kyoung Kim Jeung-Yon Rho Yong-Mahn Han Jungho Kim

J Biol Chem 2006 Nov 1;281(44):33554-65. Epub 2006 Sep 1.

Laboratory of Molecular and Cellular Biology, Department of Life Science, Sogang University, Seoul 121-742, Korea.

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November 2006

Proteomic analysis of the extraembryonic tissue from cloned porcine embryos.

Authors:
Jung-Il Chae Seong-Keun Cho Jung-Woo Seo Tae-Sung Yoon Kyu-Sun Lee Jin-Hoi Kim Kyung-Kwang Lee Yong-Mahn Han Kweon Yu

Mol Cell Proteomics 2006 Sep 30;5(9):1559-66. Epub 2006 Jun 30.

Centre for Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-333, Korea.

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September 2006

Analysis of DNA methylation profiles in preimplantation embryos using bisulfite mutagenesis.

Authors:
Yong-Mahn Han Seok-Ho Kim Yong-Kook Kang

Methods Mol Biol 2006 ;325:251-60

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, Daejeon.

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July 2006

Methylation changes of lysine 9 of histone H3 during preimplantation mouse development.

Authors:
Seungeun Yeo Kyung-Kwang Lee Yong-Mahn Han Yong-Kook Kang

Mol Cells 2005 Dec;20(3):423-8

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.

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December 2005

Inheritable histone H4 acetylation of somatic chromatins in cloned embryos.

Authors:
Gabbine Wee Deog-Bon Koo Bong-Seok Song Ji-Su Kim Man-Jong Kang Seung-Ju Moon Yong-Kook Kang Kyung-Kwang Lee Yong-Mahn Han

J Biol Chem 2006 Mar 21;281(9):6048-57. Epub 2005 Dec 21.

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoeun-dong, Yuseong, Daejeon 305-806, Korea.

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March 2006

Effects of in vitro fertilization conditions on preimplantation development and quality of pig embryos.

Authors:
Deog-Bon Koo Yong-Jun Kim Iljung Yu Ha-Na Kim Kyung-Kwang Lee Yong-Mahn Han

Anim Reprod Sci 2005 Nov;90(1-2):101-10

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, Daejeon.

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November 2005

Transcriptional profiling of the developmentally important signalling pathways in human embryonic stem cells.

Authors:
Jeung-Yon Rho Kweon Yu Jee-Soo Han Jung-Il Chae Deog-Bon Koo Hyun-Soo Yoon Shin-Yong Moon Kyung-Kwang Lee Yong-Mahn Han

Hum Reprod 2006 Feb 20;21(2):405-12. Epub 2005 Oct 20.

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoeun-dong Yuseong-gu, Daejeon 305-806, Korea.

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February 2006

Inactivation of MPF and MAP kinase by single electrical stimulus for parthenogenetic development of porcine oocytes.

Authors:
Deog-Bon Koo Jung-Il Chae Ji-Su Kim Gabbine Wee Bong-Seok Song Kyung-Kwang Lee Yong-Mahn Han

Mol Reprod Dev 2005 Dec;72(4):542-9

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.

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December 2005

Stimulation of Oct-4 activity by Ewing's sarcoma protein.

Authors:
Jungwoon Lee Byung Kirl Rhee Gab-Yong Bae Yong-Mahn Han Jungho Kim

Stem Cells 2005 Jun-Jul;23(6):738-51

Laboratory of Molecular and Cellular Biology, Department of Life Science, Sogang University, Seoul 121-742, Korea.

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September 2005

A rare and often unrecognized cerebromeningitis and hemodynamic disorder: a major cause of sudden death in somatic cell cloned piglets.

Authors:
Mi-Rung Park Seong-Keun Cho So-Young Lee Yun-Jung Choi Jong-Yi Park Deug-Nam Kwon Woo-Jin Son Seung-Sam Paik Teoan Kim Yong-Mahn Han Jin-Hoi Kim

Proteomics 2005 May;5(7):1928-39

Major of Dairy Science, Division of Applied Life Science, GyeongSang National University, Jinji, Korea.

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May 2005

Varied patterns of DNA methylation change between different satellite regions in bovine preimplantation development.

Authors:
Yong-Kook Kang Hyo-Jong Lee Jung-Jae Shim Seungeun Yeo Seok-Ho Kim Deog-Bon Koo Kyung-Kwang Lee Zeki Beyhan Neal L First Yong-Mahn Han

Mol Reprod Dev 2005 May;71(1):29-35

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yuseong, Daejeon, Korea.

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May 2005

Differential DNA methylation reprogramming of various repetitive sequences in mouse preimplantation embryos.

Authors:
Seok-Ho Kim Yong-Kook Kang Deog-Bon Koo Man-Jong Kang Seung-Ju Moon Kyung-Kwang Lee Yong-Mahn Han

Biochem Biophys Res Commun 2004 Nov;324(1):58-63

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology (KRIBB), P.O. Box 115, Yuseong, Daejeon 305-600, Republic of Korea.

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November 2004

Drosophila short neuropeptide F regulates food intake and body size.

Authors:
Kyu-Sun Lee Kwan-Hee You Jong-Kil Choo Yong-Mahn Han Kweon Yu

J Biol Chem 2004 Dec 21;279(49):50781-9. Epub 2004 Sep 21.

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, 52 Eoun-dong, Yusong-gu, Daejeon, 395-333, Korea.

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December 2004

Reactive oxygen species induced by the deletion of peroxiredoxin II (PrxII) increases the number of thymocytes resulting in the enlargement of PrxII-null thymus.

Authors:
Eun-Yi Moon Ying Hao Han Dong-Seok Lee Yong-Mahn Han Dae-Yeul Yu

Eur J Immunol 2004 Aug;34(8):2119-28

The Laboratory of Human Genomics, Korea Research Institute of Bioscience and Biotechnology, 52 Eun-Dong, Yudong-Gu, Taejen 305-606, South Korea.

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August 2004

A paucity of structural integrity in cloned porcine blastocysts produced in vitro.

Authors:
Deog-Bon Koo Yong-Kook Kang Jung Sun Park Jin-Ki Park Won-Kyong Chang Kyung-Kwang Lee Yong-Mahn Han

Theriogenology 2004 Sep;62(5):779-89

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea.

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September 2004

Precise recapitulation of methylation change in early cloned embryos.

Authors:
Yong-Kook Kang Seungeun Yeo Seok-Ho Kim Deog-Bon Koo Jung Sun Park Gabbine Wee Jee-Soo Han Keon Bong Oh Kyung-Kwang Lee Yong-Mahn Han

Mol Reprod Dev 2003 Sep;66(1):32-7

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

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September 2003

Reprogramming DNA methylation in the preimplantation stage: peeping with Dolly's eyes.

Authors:
Yong Kook Kang Kyung Kwang Lee Yong Mahn Han

Curr Opin Cell Biol 2003 Jun;15(3):290-5

Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology, Oun-dong 52, Yusong, 305-333, Daejeon, Korea.

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June 2003

Aberrant allocations of inner cell mass and trophectoderm cells in bovine nuclear transfer blastocysts.

Authors:
Deog-Bon Koo Yong-Kook Kang Young-Hee Choi Jung Sun Park Ha-Na Kim Keon Bong Oh Dong-Soo Son Humdai Park Kyung-Kwang Lee Yong-Mahn Han

Biol Reprod 2002 Aug;67(2):487-92

Animal Developmental Biotechnology Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yusong, Daejeon 305-600, Korea.

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August 2002

Limited demethylation leaves mosaic-type methylation states in cloned bovine pre-implantation embryos.

Authors:
Yong-Kook Kang Jung Sun Park Deog-Bon Koo Young-Hee Choi Sun-Uk Kim Kyung-Kwang Lee Yong-Mahn Han

EMBO J 2002 Mar;21(5):1092-100

Animal Developmental Biotechnology Laboratory, Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Taejon 305-600, South Korea.

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March 2002