Publications by authors named "Yong Wang"

6,079 Publications

  • Page 1 of 1

Ovulation triggering with hCG alone, GnRH agonist alone or in combination? A randomized controlled trial in advanced-age women undergoing IVF/ICSI cycles.

Hum Reprod 2022 May 20. Epub 2022 May 20.

Reproductive Medical Center, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Study Question: Is a dual ovulation trigger with a combination of GnRH agonist (GnRHa) and hCG superior to single hCG and/or single GnRHa trigger in improving treatment outcomes in advanced-age women (aged ≥ 35 years) undergoing IVF/ICSI treatment?

Summary Answer: Co-administration of GnRHa and hCG as a dual trigger increases the number of good-quality embryos but it is not associated with a higher number of oocytes retrieved, compared with single hCG or GnRHa trigger.

What Is Known Already: Many studies have demonstrated that a dual trigger has positive impact on oocyte maturation, retrieval rate and pregnancy rate without increasing the risk of ovarian hyperstimulation syndrome (OHSS) in some groups of IVF patients, when compared with single hCG trigger. Few studies have however been conducted to compare a dual trigger with a single GnRHa trigger, and insufficient evidence exists to support which trigger can achieve the best outcomes in IVF patients aged ≥35 years.

Study Design, Size, Duration: This was an open-label randomized controlled trial of 510 participants conducted at single reproductive medical center from January 2019 to December 2021. After a sample size calculation performed by retrospectively analyzing our previous clinical data, we planned to recruit 170 patients in each group and 510 patients in total for the study.

Participants/materials, Setting, Methods: Women aged ≥35 years undergoing IVF/ICSI treatment, receiving a non-pituitary down-regulation protocol, and with low risk of OHSS, were enrolled in this trial. On the trigger day, patients were randomized into three groups: hCG alone (who received 6000 IU of hCG), GnRHa alone (who received 0.2 mg of triptorelin) and dual trigger (who received 0.2 mg of triptorelin plus 2000 IU of hCG) groups. The primary outcome parameter was the number of retrieved oocytes. The secondary outcome parameters included, among others, the number and rates of mature oocytes, two pronuclei (2PN) embryos and good-quality embryos, as the rates of OHSS, clinical pregnancy, miscarriage and live birth.

Main Results And The Role Of Chance: There were no significant differences in the baseline demographic characteristics among the three groups. The dual trigger was associated with a higher retrieval rate (87.9% vs 84.1% in the hCG group, P = 0.031; 87.9% vs 83.6% in the GnRHa group, P = 0.014). However, the number of retrieved oocytes in the dual trigger group was comparable with those in the hCG group (4.08 ± 2.79 vs 3.60 ± 2.71, P = 0.080) and the GnRHa group (4.08 ± 2.79 vs 3.81 ± 3.38, P = 0.101); comparable data between the groups were also found when analyzing the number of 2PN embryos and the 2PN rate. In the dual trigger group, the numbers of good-quality embryos and viable embryos were both significantly higher than in the hCG group (1.74 ± 1.90 vs 1.19 ± 1.45, P = 0.016 and 2.19 ± 2.11 vs 1.56 ± 1.66, P = 0.008, respectively) and the GnRHa group (1.74 ± 1.90 vs 1.20 ± 1.67, P = 0.003 and 2.19 ± 2.11 vs 1.45 ± 1.75, P = 0.001, respectively). Pregnancy outcomes after fresh embryo transfer (ET) were comparable between the groups. The live birth rate and ongoing pregnancy rate after frozen ET in the dual trigger group were significantly higher than those in the GnRHa group (32.6% vs 14.1%, P = 0.007 and 34.8% vs 17.6%, P = 0.013, respectively), but not superior to those in the hCG group (32.6% vs 27.9%, P = 0.537 and 34.8% vs 27.9%, P = 0.358, respectively).

Limitations, Reasons For Caution: Women of advanced age are quite a heterogeneous population and overlap with poor ovarian responders or patients with diminished ovarian reserve. We therefore could not entirely exclude selection biases or confounding factors. This study was also not a double-blinded trial; the patients in the GnRHa and dual trigger groups could have been affected by the placebo effect.

Wider Implications Of The Findings: The results of this study suggest that in advanced-age women with low risk of OHSS, a dual trigger or even a single hCG trigger may be a better choice than a single GnRHa trigger.

Study Funding/competing Interest(s): This study was supported by the Shanghai Municipal Health Commission of Science and Research Fund (20184Y0289). The authors declare no conflict of interest.

Trial Registration Number: This trial was registered in the Chinese Clinical Trial Registry (ChiCTR-1800016285).

Trial Registration Date: 24 May 2018.

Date Of First Patient’s Enrolment: 2 January 2019.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/humrep/deac114DOI Listing
May 2022

Dendrobium officinale polysaccharides attenuate uropathogenic Escherichia coli (UPEC)-induced pyroptosis in macrophage cells.

Biomed Pharmacother 2022 May 17;151:113098. Epub 2022 May 17.

Central Laboratory, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Nanjing 210014, China.

Urinary tract infections (UTI) are recognized as one of the most common infectious diseases worldwide, and uropathogenic Escherichia coli (UPEC) is the main causative agent of UTI. Dendrobium officinale polysaccharides (DOPs), the main effective ingredient in Dendrobium officinale, have been reported to possess an anti-inflammatory role. Whether DOPs can attenuate the inflammatory injury (pyroptosis) induced by UPEC remains unknown. The present study aimed to assess the protective effect and potential mechanism of DOPs in UPEC-induced pyroptosis. Cell viability of THP-1 differentiated macrophage cells with DOPs was determined using MTT assay. Pyroptosis by UPEC in macrophage cells with or not DOPs pre-treatment was evaluated with flow cytometry analysis, lactate dehydrogenase (LDH) assay, and proinflammatory cytokines secretion. Expression level of key proteins in the NLRP3/Caspase-1/GSDMD pyroptotic pathway was analyzed with western blot. Furthermore the effect of DOPs on ROS activation was investigated. Results indicated that DOPs attenuated UPEC-induced cell damage in macrophage cells, inhibited the activation of NLRP3 mediated inflammasome, subsequently decreased induction and activation of caspase-1/GSDMD, and reduced the secretion of pro-inflammatory cytokine (IL-1β et al.). Moreover, pretreatment with DOPs significantly reduces ROS production, an important/putative pyroptosis stimulus signal. These results suggested that DOPs successfully mitigate UPEC-promoted pyroptosis in macrophage cells. The protective effects of DOPs are associated with the inhibition of the NLRP3/Caspase-1/GSDMD pathway and ROS signal activation.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biopha.2022.113098DOI Listing
May 2022

Brucella melitensis outer membrane protein 25 interacts with ferritin heavy polypeptide 1 in human trophoblast cells.

Mol Med Rep 2022 Jul 20;26(1). Epub 2022 May 20.

College of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang 832003, P.R. China.

Outer membrane protein 25 (OMP25) is involved in virulence and serves an important role in pathogenesis during infection. However, the protein interacting with OMP25 in host cells remains to be elucidated. The present study constructed a cDNA library from 16M‑infected human placenta trophoblastic cells (HPT‑8) and identified and confirmed the interaction between OMP25 and ferritin heavy polypeptide 1 (FTH1) of HPT‑8 using yeast two‑hybrid and co‑immunoprecipitation technologies. The expression of Toll‑like receptor (TLR)4, myeloid differentiation primary response protein MyD88 (MyD88) mRNA and inflammatory factors was detected by RNA interference. The results showed that OMP25 interacted with FTH1. Subsequently, TLR4 and MyD88 mRNA expression levels and inflammatory factors, such as nitric oxide, lactate dehydrogenase and TNF‑α, significantly increased after inserting OMP25 into the HPT‑8 cells. Notably, a low dose of OMP25 resulted in immunological protection, whereas high dose of OMP25 resulted in a cytotoxic effect on the HPT‑8 cells. It is suggested that OMP25 and FTH1 serve important roles in intracellular parasitism of and inhibition of expression.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2022.12740DOI Listing
July 2022

Lactic acid bacteria isolated from Kazakh traditional fermented milk products affect the fermentation characteristics and sensory qualities of yogurt.

Food Sci Nutr 2022 May 19;10(5):1451-1460. Epub 2022 Apr 19.

China-Australia Joint Research Center for Dairy Future Technology Beijing Key Laboratory of Nutrition, Health & Food Safety Beijing Engineering Laboratory for Geriatric Nutrition Food Research COFCO Nutrition & Health Research Institute Beijing China.

Lactic acid bacteria (LAB) play a crucial role in the development of the taste, texture, and aroma of traditional fermented milk products. Five LABs from Kazakh traditionally prepared dairy products showed continuous subculture stability, as well as proper acidification and coagulation ability. They were identified as (1-5, 1-7), (1-19), and (1-12, 1-15). Their coagulation time and acidity values ranged from 5.97 to 12.78 h and 76.47 to 89.39°T. Yogurts prepared with were more condensed and textural integrity than those with and . Determination of the volatile compound profiles suggested a higher diversity of volatile compounds than the control. The sensory evaluation presented positive overall sensory quality scores for the yogurts prepared with 1-12 and 1-15. The results provide additional information regarding the contributions of native LABs to the unique flavor and sensory qualities of traditionally prepared milk products. They may help to select starters or adjunct starters for developing distinctive, traditional nomadic fermented milk to satisfy consumer demand and increase market acceptability.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/fsn3.2755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094460PMC
May 2022

DNA-Mediated Assembly of Carbon Nanomaterials.

Chempluschem 2022 Apr 26;87(5):e202200089. Epub 2022 Apr 26.

College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Artificial Functional Materials, Chemistry and Biomedicine Innovation Center, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, 210023, Nanjing, P. R. China.

Carbon nanomaterials (CNMs) have attracted extensive attentions on account of their superior electrical, mechanical, optical, and biological properties. However, the dimensional limit and irregular arrangement have hampered their further application. It is necessary to find an easy, efficient and controllable way to assemble CNMs into well-ordered array. DNA nanotechnology, owning to the advantages of precise programmability, highly structural predictability and spatial addressability, has been widely applied in the assembly of CNMs. Summarizing the progress and achievements in this field will be of great value to related studies. Herein, based on the different dimensions of CNMs containing 0-dimensional (0D) carbon dots (CDs), fullerenes, 1-dimensional (1D) carbon nanotubes (CNTs) and 2-dimensional (2D) graphene, we introduced the conjugation strategies between DNA and CNMs, their different assembly methods and their applications. In addition, we also discuss the existing challenges and future opportunities in the field.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/cplu.202200089DOI Listing
April 2022

Preparing guiding planes for removable partial dentures: comparison between assisted CAD-CAM template procedure and freehand preparation: An in vitro study.

J Dent 2022 May 16:104166. Epub 2022 May 16.

Center of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Beijing, PR China. Electronic address:

Objectives: To compare the trueness of computer-aided design and computer-aided manufacturing (CAD-CAM) assisted procedure and freehand procedure for preparing guiding planes for removable partial dentures (RPDs).

Methods: Forty identical mandibular resin casts were divided into two groups in which the guiding planes of two abutment teeth were prepared freehand (control group, n = 20) and using rigidly constrained templates (test group, n = 20). The template was designed on a digital cast of virtually prepared guiding planes and fabricated by selective laser melting using cobalt-chromium alloy. To assess the 3D trueness, all prepared guiding planes (Test data) were digitized using a laboratory scanner and compared to the virtually designed guiding planes (Reference data). The angle deviation between the Test data and the designed direction of the path of placement was measured for assessing the direction trueness of guiding plane preparation.

Results: The 3D trueness of guiding plane preparation was significantly better in the test group (48.4 ± 12.9 μm) than in the control group (128.5 ± 37.6 μm, p < 0.01). The direction trueness of guiding plane preparation was also significantly better in the test group (1.20 ± 0.55°) than in the control group (7.68 ± 3.00°, p < 0.01).

Conclusions: The CAD-CAM template assisted procedure can significantly improve tooth preparation of the guiding planes compared to the freehand preparation. The CAD-CAM template could help clinicians prepare parallel guiding planes in a predictable manner.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdent.2022.104166DOI Listing
May 2022

Novel scheme towards interfacial charge transfer between ZnInS and BiOBr for efficient photocatalytic removal of organics and chromium (VI) from water.

Chemosphere 2022 May 16:134973. Epub 2022 May 16.

Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes, Ministry of Education, College of Environment, Hohai University, Nanjing, 210098, PR China.

Construction of Z-scheme heterostructure is an effective strategy to enhance the charge carriers' separation. However, successfully achieving this on the defect heterojunction to improve the photocatalytic activity remains challenging. This work successfully obtained sulfur vacancy in the ZnInS/BiOBr (SZIS/BOB) heterojunction composites with S-O covalent bonding using a hydrothermal method. As a result, they exhibited superior photocatalytic and stability performance. The optimized SZIS/BOB-10 exhibited excellent rhodamine B degradation (95.2%) and chromium (VI) reduction (97.8%) within 100 min under visible light. The enhanced composites with S-vacancies, S-O bond, and internal electric field induced the Z-scheme charge transfer mechanism. We had verified this mechanism based on the surface photovoltage spectra, electron spin response spectra, and density functional theory calculations. This work not only provides valuable insights into designing photocatalysts with a direct Z scheme heterostructure but also delineates a promising strategy for developing efficient photocatalysts to degrade organic pollutants.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2022.134973DOI Listing
May 2022

Femtosecond Laser for Cavity Preparation in Enamel and Dentin: Axial Wall Taper Related Factors.

Photobiomodul Photomed Laser Surg 2022 May 19. Epub 2022 May 19.

Center of Digital Dentistry, Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, P.R. China.

Femtosecond laser (fs-laser) is a novel tooth preparation tool. After cavities were prepared by fs-laser, their axial-wall taper is closely related to the retention force and success of restorations, while the taper after preparation by fs-laser is not clear yet. This study aimed to explore the value of the taper after fs-laser tooth preparation and the effect of laser fluence, scanning line spacing, and scanning layers on taper. Twenty cavities with a width of 0.5 mm were prepared by an fs-laser both in enamel and dentin to obtain the axial-wall taper (No. PKUSSIRB-201949124). To study the effects of three parameters of fs-laser, five different laser fluence were set as 1.56, 3.13, 4.69, 6.25, and 7.81 J/cm of five cavities. Scanning line spacing was set as 6, 12, 25, 30, 40, and 50 μm of six cavities and the scanning layers were 5, 10, 25, 50, 75, 100, 200, 300, and 400, respectively, of nine cavities. Laser pulses irradiated perpendicular to the tooth and the scanning path was controlled via a vibratory mirror. The taper was measured with a laser confocal microscope. Curves of the taper versus different parameters were drawn. There was a significant difference in taper between enamel and dentin. Overall, the taper decreased gradually with the increase of laser fluence. The optimal taper obtained was 20.53° ± 0.28° in dentin and 38.71° ± 0.46° in enamel when the corresponding fluence was 6.25 J/cm. In comparison, the scanning line spacing has little effect on the taper. The scanning layers significantly affect the taper, which decreased dramatically as scanning layers increased within 75 layers and does not change considerably as it was beyond 100 layers. Reasonable selection of laser fluence, scanning line spacing, and the number of scanning layers can optimize the cavity taper by fs-laser.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1089/photob.2021.0126DOI Listing
May 2022

Carotid artery stenting versus carotid endarterectomy in the treatment of symptomatic and asymptomatic carotid stenosis: a systematic review and meta-analysis.

J Interv Med 2018 Feb 30;1(1):42-48. Epub 2019 Apr 30.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology,, Wuhan 430022, China.

To evaluate the short-term and intermediate- to long-term efficacy and safety of carotid artery stenting (CAS) compared with carotid endarterectomy (CEA). The published literature was electronically searched for randomized controlled trials (RCTs) between CAS and CEA for the treatment of carotid stenosis performed from January 2000 to January 2017. The short-term and intermediate- to long-term outcomes were evaluated. We identified 10 RCTs including 7,183 participants with symptomatic or asymptomatic carotid stenosis. Our meta-analysis found different results between the patients with and those without symptoms. In patients with symptomatic carotid stenosis, the total stroke incidence in the CAS group was significantly higher than that in the CEA group within the 30-day periprocedural period (p<0.001); however, the myocardial infarction incidence in the CAS group was significantly lower than that in the CEA group (p<0.05). There was no significant difference between the two groups in the mortality within 30 days post-procedure, but the intermediate- to long-term incidence of stroke or death in the CAS group was higher than that of the CEA group (p<0.05). In contrast, for asymptomatic patients, there were no significant differences between the CAS and CEA groups in the short- and intermediate- to long-term outcomes. For patients with symptomatic carotid stenosis, CEA is associated with an increased risk of myocardial infarction, whereas CAS is correlated with an increased risk of procedurally related strokes. However, for patients with asymptomatic carotid stenosis, no significant difference was found in the efficacy or safety between CAS and CEA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.19779/j.cnki.2096-3602.2018.01.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607462PMC
February 2018

Safety and efficacy of Endovascular Management of high-grade blunt renal injury.

J Interv Med 2022 Feb 26;5(1):23-27. Epub 2022 Feb 26.

Department of Interventional Radiology, The Second Affiliated Hospital of Hainan Medical University, China.

Objectives: To provide data on the safety and efficacy of renal arterial embolization (RAE) in patients with high-grade blunt renal injury.

Materials And Methods: Fifteen patients with high-grade blunt renal injury (AAST grades IV-V) admitted to our hospital from July 2014 to December 2019 were retrospectively reviewed in this study. Their clinical success rate and complications were investigated accordingly.

Results: Fifteen patients with high-grade blunt renal injury, 13 men and 2 women with an average age of 41.6 years, including 11 hemodynamically unstable patients and 4 stable patients, were treated with RAE. Among these patients, 73.3% (11 of 15) had grade IV, and 26.7% (4 of 15) had grade V injuries, while 53.3% (8 of 15) patients had concomitant injuries. One patient received main RAE and 14 patients received selective RAE. The clinical success rate after the first embolization was 93.3% (14 of 15). RAE was repeated and was successfully performed in one patient with sustained hematuria. No significant difference in creatinine levels was found before and after embolization. During the follow-up period of 2-82 months, two patients required tube drainage due to urine leaks, one patient developed renal failure requiring renal replacement therapy, and one patient developed secondary hypertension.

Conclusions: RAE can provide a high success rate of hemostasis for both hemodynamically stable and unstable patients with high-grade blunt renal injury, and only minor complications are observed with this procedure.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jimed.2021.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947991PMC
February 2022

Revealing Surface Restraint-Induced Hexagonal Pd Nanocrystals via Transmission Electron Microscopy.

Nano Lett 2022 May 18. Epub 2022 May 18.

Center of Electron Microscopy and State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Achieving metal nanocrystals with metastable phase draws much attention due to their anticipated fascinating properties, wheras it is still challenging because their polymorphism nature and phase transition mechanism remain elusive. Here, phase stability of face-centered cubic (fcc) Pd nanocrystals was studied via spherical aberration (Cs)-corrected transmission electron microscopy (TEM). By constructing a well-defined Pd/C composite structure, Pd nanocrystals encapsulated by graphite, the dispersion process of fcc Pd was observed through a nucleation and growth process. Interestingly, Cs-corrected scanning TEM analysis demonstrated that the newly formed Pd nanocrystals could adopt a metastable hexagonal phase, which was considered challenging to obtain. Accordingly, formation mechanism of the hexagonal Pd nanocrystals was proposed, which involved the combined effect of two factors: (1) templating of graphite and (2) size effect. This work is expected to offer new insight into the polymorphism of Pd nanocrystals and pave the way for the future design of metastable metal nanomaterials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.nanolett.2c00411DOI Listing
May 2022

The joint detection of CEA and ctDNA in cerebrospinal fluid: an auxiliary tool for the diagnosis of leptomeningeal metastases in cancer.

J Cancer Res Clin Oncol 2022 May 18. Epub 2022 May 18.

Shandong Cancer Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.

Background: Leptomeningeal metastases (LMs) are highly invasive which leads to poor prognosis, but the accurate diagnosis of LM is challenging. It is necessary to investigate more advanced diagnostic methods to realize precision medicine. The main purpose of this study was to select a more effective method for the auxiliary diagnosis of LM by comparing various detection methods. The secondary purpose was to explore the value of cerebrospinal fluid (CSF) tumor markers (TMs) and circulating tumor DNA (ctDNA) testing in guiding clinical treatment.

Methods: TMs in serum and CSF of patients were detected by chemiluminescence. The ctDNA of CSF and plasma were detected by the next-generation sequencing (NGS) technology.

Results: In total, 54 tumor patients participated in this study, in which 39 with LM and 15 without LM (8 with parenchymal tumor and 7 without brain metastasis). The results showed that the sensitivity and accuracy of CSF cytology isolated during the first lumbar puncture were 0.31 (95% CI 0.17-0.48) and 0.50 (95% CI 0.36-0.64), respectively. The sensitivity and accuracy of CSF_CEA were 0.71 (95% CI 0.54-0.85) and 0.78 (95% CI 0.64-0.89), which were better than those of CSF_NSE and CSF_CFRA-211. The sensitivity and accuracy of CSF_ctDNA were 0.92 (95% CI 0.79-0.98) and 0.91 (95% CI 0.80-0.97), significantly higher than that of CSF cytology (P < 0.01). The sensitivity and accuracy of CSF_CEA combined with CSF_ctDNA were 0.97 (95% CI, 0.87-1.00) and 0.94 (95% CI 0.85-0.99), which were significantly higher than the traditional methods CSF cytology (P < 0.01). For LM patients with hydrocephalus, the sensitivity of CSF ctDNA even achieved 100% (14/14).

Conclusion: CSF_CEA combined with CSF_ctDNA could be used to accurately distinguish patients with LM from those with no brain metastasis and from those with parenchymal tumors. CSF_ctDNA testing reveals a unique mutation profile for patients with LM. Dynamic detection of CSF TM and ctDNA can better predict the efficacy and reveal the cause of drug resistance to guide subsequent treatment.

Clinical Trial Registration: Clinical trial registration number: NCT03029065.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00432-022-04053-7DOI Listing
May 2022

Surface Oxygen Vacancies Confined by Ferroelectric Polarization for Tunable CO Oxidation Kinetics.

Adv Mater 2022 May 17:e2202072. Epub 2022 May 17.

State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China.

Surface oxygen vacancies have been widely discussed to be crucial for tailoring the activity of various chemical reactions from CO, NO to water oxidation by using oxide-supported catalysts. However, the real role and potential function of surface oxygen vacancies in the reaction remains unclear because of their very short life-time. Here we report that surface oxygen vacancies can be well confined electrostatically for a polarization screening near the perimeter interface between Pt {111} nanocrystals and the negative polar surface (001) of ferroelectric PbTiO Strikingly, such a catalyst demonstrates a tunable catalytic CO oxidation kinetics from 200 °C to near room temperature by increasing O gas pressure, accompanied with the conversion curve from a hysteresis-free loop to hysteresis one. The combination of reaction kinetics, electronic energy loss spectroscopy (EELS) analysis and density functional theory (DFT) calculations, indicates that the oxygen vacancies stabilized by the negative polar surface are the active sites for O adsorption as a rate-determining step and then dissociated O moves to the surface of Pt nanocrystals for oxidizing adsorbed CO. Our results open a new pathway for tunable catalytic activity of CO oxidation. This article is protected by copyright. All rights reserved.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.202202072DOI Listing
May 2022

Analysis of Time to the Hospital and Ambulance Use Following a Stroke Community Education Intervention in China.

JAMA Netw Open 2022 May 2;5(5):e2212674. Epub 2022 May 2.

Department of Neurology, Minhang Hospital, Fudan University, Minhang District, Shanghai, China.

Importance: Prehospital delay (time from symptom onset of stroke to the door of a hospital) in patients with stroke is long in China. With the goal of improving public awareness and knowledge of stroke recognition, Stroke 1-2-0 was developed in China as an education program to prompt rapid response to the onset of stroke based on clinical practice in China, and examination of its outcomes is needed.

Objective: To investigate the association of the Stroke 1-2-0 educational campaign with prehospital delay for patients with ischemic stroke.

Design, Setting, And Participants: In a population-based cross-sectional study, all patients with ischemic stroke events were admitted to the Minhang Hospital, which is the only tertiary care hospital with a stroke center that provides acute stroke care in Xinzhuang county, Shanghai, China. The study period was from January 1, 2016, to December 31, 2019, and data analysis was performed from January 1 to July 31, 2021.

Exposures: A multifaceted Stroke 1-2-0 educational campaign comprising slides, videos, brochures, and posters distributed in the community.

Main Outcomes And Measures: Proportion of patients with hospital arrival within 3 hours and use of an ambulance to seek medical care, as well as the odds of seeking medical attention within 3 hours after the stroke before vs after initiation of the multifaceted educational campaign.

Results: A total of 2857 patients (1774 men [62.1%]; mean [SD] age, 69.83 [12.66] years) with stroke were identified, including 503 in the precampaign period and 2354 in the postcampaign period. Following the multifaceted campaign, the median (IQR) prehospital delay time decreased from 18.72 (7.44-27.84) hours to 6.00 (2.00-16.35) hours (P < .001). After the implementation of the Stroke 1-2-0 campaign, the proportion of patients with hospital arrival time within 3 hours increased from 5.8% to 33.4% (P < .001) and use of an ambulance increased from 3.2% to 30.6% (P < .001). In an interrupted time series analysis, the initiation of the Stroke 1-2-0 campaign was associated with significantly increased odds of arriving at the hospital within 3 hours (odds ratio, 8.01; 95% CI, 7.17-8.95; P < .001) and use of an ambulance (odds ratio, 9.41; 95% CI, 8.24-10.74; P < .001).

Conclusions And Relevance: The persistent multifaceted campaign using the Stroke 1-2-0 program was associated with reduced prehospital delay and improved timely arrival rate and ambulance arrival rate for patients with stroke. These findings suggest that Stroke 1-2-0 can be adopted in other regions of China to possibly improve health outcomes and reduce clinical burdens for all patients with stroke.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2022.12674DOI Listing
May 2022

The significant role of the atomic surface structure of support in strong metal-support interaction.

Authors:
Min Tang Yong Wang

Chemistry 2022 May 17. Epub 2022 May 17.

Zhejiang University, Materials Science and Engineering, 38 Zheda Road, 310027, Hangzhou, CHINA.

Supported metal catalysts are important in many industrial reactions. It is reported that support materials are not always inert, and in some cases could even interact with metal nanoparticles (NPs) actively via various ways. In particular, the strong metal-support interaction (SMSI), referring to metal NPs covered by support materials, affects catalysis at the active sites on the metal NP surface, which can serve as a very effective method in tuning and improving catalytic performance. By tailoring the support materials or controlling the treatment processes, different kinds of SMSI, such as classical SMSI, oxidative SMSI, wet-chemistry SMSI, and adsorbate-mediated SMSI , can be achieved. This concept summarizes the general strategies to tune SMSI and discusses the key results. Moreover, a new proposal is presented to tailor SMSI by combining both the exposed facets of the support materials and external environments. Furthermore, we have discussed the challenges faced at present and provide useful insights for future research concerning this topic.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/chem.202104519DOI Listing
May 2022

Contrast-enhanced ultrasound-based nomogram for predicting malignant involvements among sonographically indeterminate/suspicious cervical lymph nodes in patients with differentiated thyroid carcinoma.

Ultrasound Med Biol 2022 May 13. Epub 2022 May 13.

Department of Ultrasound, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Panjiayuannanli No. 17, Chaoyang District, Beijing 100021, China. Electronic address:

This prospective study was aimed at assessing the value of nomograms based on conventional and contrast-enhanced ultrasound (CEUS) features in the pre-operative diagnosis of sonographically indeterminate/suspicious lymph node metastasis (LNM) in patients with differentiated thyroid carcinoma (DTC). A total of 72 cervical LNs from 47 patients with DTC from January to June 2018 were included in the primary data set, and 30 LNs from 15 patients with DTC from July to August 2018 were included in the external validation data set. The LNs of the included patients were preoperatively evaluated by conventional ultrasound (US) and CEUS. Each included LN was labeled by puncture localization with carbon nanoparticle suspension injection (Canalin) under US guidance and dissected separately to ensure the one-to-one correspondence between ultrasonic features and pathology status. Univariate logistic regression analysis was used to identify risk factors for LNM. A nomogram was used to construct a prediction model for cervical metastatic LNs. Round shape, absence of hilar structure, peripheral or mixed blood flow and centripetal or mass enhancement were risk factors for lymph node metastases. The area under the receiver operating characteristic curve of the nomogram model based on conventional US and CEUS features was 0.93 (95% confidence interval: 0.872-0.985), which was superior to that of the nomogram based on conventional US features(0.85, 95% confidence interval: 0.707-0.989). CEUS features can provide incremental benefit in the diagnosis of LNM among DTC cohorts. Nomograms based on conventional US and CEUS features can predict LN status with high accuracy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ultrasmedbio.2022.04.004DOI Listing
May 2022

Value of Immunohistochemical Expression of Apelin, Succinate Dehydrogenase B, Chromogranin B, Human Epidermal Growth Factor Receptor-2, Contactin 4, and Succinyl-CoA Synthetase Subunit Beta in Differentiating Metastatic From Non-Metastatic Pheochromocytoma and Paraganglioma.

Front Endocrinol (Lausanne) 2022 28;13:882906. Epub 2022 Apr 28.

Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Objective: We aimed to retrospectively collect pathologically identified pheochromocytoma and paraganglioma (PPGL) tumor tissues from our center and investigate the expression of apelin and succinyl-CoA synthetase subunit beta (SUCLG2), human epidermal growth factor receptor-2 (HER2 or ERBB-2), contactin 4 (CNTN4), chromogranin B (CHGB), and succinate dehydrogenase B (SDHB) in metastatic and non-metastatic PPGLs, for exploring their roles in the diagnosis of metastatic PPGLs.

Methods: A total of 369 patients with pathologically and surgically confirmed PPGLs at Xiangya Hospital, Central South University, between June 2010 and June 2020 were retrospectively included. Sixty patients-12 patients with metastatic PPGLs and 48 patients with non-metastatic PPGLs-were selected through propensity score matching (1:4) to reduce the effect of PPGL type, sex, and age. We observed and quantified the expression of apelin, SDHB, CHGB, ERBB-2, CNTN4, and SUCLG2 in paraffin-embedded samples using immunohistochemical staining.

Results: No significant differences were observed between the metastatic group and non-metastatic group with respect to the expression of CNTN4 and SUCLG2. The expression of apelin, SDHB, CHGB, and ERBB-2 was significantly different between the two groups. The expression of apelin, SDHB, and CHGB was significantly lower in the metastatic group than that in the non-metastatic group (P < 0.001). ERBB-2 expression was significantly higher in the metastatic group than in the non-metastatic group (P = 0.042). Kaplan-Meier analysis revealed that patients with negative expression of apelin, SDHB, and CHGB showed significantly lower metastasis-free survival than those with positive expression. Multivariate Cox analysis revealed that SDHB and CHGB levels were independently associated with metastasis-free survival.

Conclusion: The expression levels of apelin, CHGB, SDHB, and ERBB-2 may be predictive biomarkers for the diagnosis of metastatic PPGLs. Patients with negative expression of apelin, CHGB, and SDHB should be subjected to frequent postoperative follow-up procedures.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fendo.2022.882906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096168PMC
May 2022

EEG Evidence Reveals Zolpidem-Related Alterations and Prognostic Value in Disorders of Consciousness.

Front Neurosci 2022 27;16:863016. Epub 2022 Apr 27.

Department of Electronic Engineering, Beijing National Research Center for Information Science and Technology (BNRist), Tsinghua University, Beijing, China.

Effective treatment and accurate long-term prognostication of patients with disorders of consciousness (DOC) remain pivotal clinical issues and challenges in neuroscience. Previous studies have shown that zolpidem produces paradoxical recovery and induces similar change patterns in specific electrophysiological features in some DOC (∼6%). However, whether these specific features are neural markers of responders, and how neural features evolve over time remain unclear. Here, we capitalized on static and dynamic EEG analysis techniques to fully uncover zolpidem-induced alterations in eight patients with DOC and constructed machine-learning models to predict long-term outcomes at the single-subject level. We observed consistent patterns of change across all patients in several static features (e.g., decreased relative theta power and weakened alpha-band functional connectivity) after zolpidem administration, albeit none zolpidem responders. Based on the current evidence, previously published electrophysiological features are not neural markers for zolpidem responders. Moreover, we found that the temporal dynamics of the brain slowed down after zolpidem intake. Brain states before and after zolpidem administration could be completely characterized by the EEG features. Furthermore, long-term outcomes were accurately predicted using connectivity features. Our findings suggest that EEG neural signatures have huge potential to assess consciousness states and predict fine-grained outcomes. In summary, our results extend the understanding of the effects of zolpidem on the brain and open avenues for the application prospect of zolpidem and EEG in patients with DOC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2022.863016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093050PMC
April 2022

Easily Functionalized and Readable Sequence-Defined Polytriazoles.

ACS Macro Lett 2021 05 20;10(5):551-557. Epub 2021 Apr 20.

State Key Laboratory of Organic-Inorganic Composites, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Developing sequence-defined skeletons that could be conveniently characterized and functionalized with diverse side groups is attractive but challenging. Here we report one novel sequence-defined polytriazole structure bearing side groups at its triazole rings. Its construction was facilely accessed by the iterative employments of azidation and iridium-catalyzed cycloaddition of azide with internal 1-thioalkyne (IrAAC) in solution phase. The easy preparation of 1-thioalkyne monomers and the excellent tolerance of IrAAC enable the introduction of diverse functional side chains to this architecture. The obtained sequence was effectively characterized by tandem mass spectrometry owing to the efficient fractures of both of the Csp-S and Csp-N bonds in its backbone, indicating its potential utilization in high-capacity digital polymer developments. Further successful application of this structure in building monodisperse macromolecules exhibiting aggregation-induced emission (AIE) characteristics demonstrates its expected application in functional material fabrications.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsmacrolett.1c00145DOI Listing
May 2021

Comparison of four CAD-CAM guides for preparing guiding planes of removable partial dentures.

Comput Biol Med 2022 Apr 29;146:105564. Epub 2022 Apr 29.

Center of Digital Dentistry, Faculty of Prosthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Beijing, PR China.

Background And Objective: To evaluate the effect of guiding structure and 3D-printing material of CAD-CAM guides on the accuracy of guiding planes preparation.

Methods: Four types of computer-aided design and computer-aided manufacturing (CAD-CAM) guides for preparing guiding planes of removable partial denture (RPD) were designed in two types of guiding structures (triple-constraint and single-plane constraint) and were 3D printed using resin and cobalt-chromium (Co-Cr) alloy. Guiding plane preparation of identical resin casts was performed using CAD-CAM guides (resin template, metal template, resin guided device, and metal guide device) in four test groups and by freehand in the control group (n = 22 per group). All prepared casts were then scanned (Test) and aligned to the reference cast with designed guiding planes. 3D compare analysis was performed and root-mean-square (RMS) values were calculated for assessing the 3D trueness and 3D precision of guiding plane preparation. The angle between the prepared guiding plane (Test) and the designed path of placement of RPD (Reference) was measured for evaluating the direction trueness.

Results: RMS values of the metal template group for 3D trueness (39.7 ± 14.6 μm) and 3D precision (28.6 ± 6.8 μm) were significantly lower than that of other groups (p < .05). For direction trueness, the metal template group showed the least angle deviation (1.09 ± 0.56°), and the freehand group demonstrated the largest angle deviation (7.03 ± 2.83°).

Conclusions: The Co-Cr alloy guides with triple-constraint guiding structure can assist to prepare accurate guiding planes of RPD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.compbiomed.2022.105564DOI Listing
April 2022

Flaxseed oil ameliorates aging in D-galactose induced rats via altering gut microbiota and mitigating oxidative damage.

J Sci Food Agric 2022 May 14. Epub 2022 May 14.

Department of Food Science and Engineering, Jinan University, Guangzhou, 510632, Guangdong, China.

Background: Aging causes decreased antioxidant capacity and chronic inflammation and may even elevate cancer risks. Previous studies reported that flaxseed oil (FO) can alleviate age-related diseases, including improving alcoholic liver disease, atherosclerosis and diabetes. However, whether the intestinal microbiota accountable for this alleviation is still unknown. This study aims to study the antioxidant effects of FO in an aging rat model and the underlying mechanism between the intestinal microbiota and aging.

Results: Our results presented that serum and liver antioxidant capacities in FO group were up-regulated, and liver inflammation in FO group was reduced. 16S rDNA sequencing showed that FO regulated the microbial community, including up-regulation of 4 families of Lactobacillus and 6 families of Clostridium. In addition, FO had also adjusted the relative abundance of several genera such as Ruminococcaceae_UCG-005 and Prevotella_9, which may be the key bacteria associated with the aging process. Colonic transcriptome analysis showed that there were 1679 differentially expressed genes (DEGs) in the Model group and the FO group (134 up-regulated and 1545 down-regulated). Gene set enrichment analysis (GSEA) revealed FO down-regulates the expression of the upstream genes Ptprc, Lck, Zap70, Lat and Lcp2 in the T cell receptor signaling pathway.

Conclusion: In conclusion, FO improved antioxidant capacity and reduced intestinal microbial disturbances caused by aging damage, indicating that dietary FO has the potential to fight aging damage. This study provides a more comprehensive view of dietary intervention to improve the aging. This article is protected by copyright. All rights reserved.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/jsfa.12010DOI Listing
May 2022

Long Non-Coding RNA Regulates Ovine Granulosa Cells Apoptosis by Affecting the Expression of Apoptosis-Related Genes.

Int J Mol Sci 2022 May 6;23(9). Epub 2022 May 6.

College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China.

Short-term dietary supplementation of ewes during the luteal phase can increase fertility, most probably by stimulating glucose uptake by the follicles. However, the molecular mechanism of glucose regulation of follicular development has not yet been clarified, especially the further study of long non-coding RNA (lncRNA) in determining fertility during follicular development. We generated granulosa cell (GC) models of different doses of glucose (0, 2.1, 4.2, 8.4, 16.8 and 33.6 mM), and observed that the highest cell viability was recorded in the 8.4 mM group and the highest apoptosis rates were recorded in the 33.6 mM group. Therefore, a control group ( = 3, 0 mM glucose), a low glucose group ( = 3, add 8.4 mM glucose), and a high glucose group ( = 3, add 33.6 mM glucose) of GCs were created for next whole genomic RNA sequencing. In total, 18,172 novel lncRNAs and 510 annotated lncRNAs were identified in the GCs samples. Gene Ontology indicated that differentially expressed lncRNAs associated with cell apoptosis were highly enriched. Kyoto Encyclopedia of Genes and Genomes enrichment analysis of lncRNA target genes found that the apoptosis pathway and the p53 signaling pathway were both enriched. Furthermore, we focused on the function of a lnc and verified that lncG could influence cell apoptosis in GC development through affecting the mRNA and protein expression of apoptosis-related markers. These results provide the basis for further study of the lncRNA regulation mechanism in nutrition on female fertility.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms23095183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9104640PMC
May 2022

Global DNA Methylation and mRNA-miRNA Variations Activated by Heat Shock Boost Early Microspore Embryogenesis in Cabbage ().

Int J Mol Sci 2022 May 5;23(9). Epub 2022 May 5.

Key Laboratory of Biology and Genetic Improvement of Horticultural Crops, Ministry of Agriculture, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China.

Microspore culture, a type of haploid breeding, is extensively used in the cultivation of cruciferous crops such as cabbage. Heat shock (HS) treatment is essential to improve the embryo rate during the culture process; however, its molecular role in boosting early microspore embryogenesis (ME) remains unknown. Here we combined DNA methylation levels, miRNAs, and transcriptome profiles in isolated microspores of cabbage '01-88' under HS (32 °C for 24 h) and normal temperature (25 °C for 24 h) to investigate the regulatory roles of DNA methylation and miRNA in early ME. Global methylation levels were significantly different in the two pre-treatments, and 508 differentially methylated regions (DMRs) were identified; 59.92% of DMRs were correlated with transcripts, and 39.43% of miRNA locus were associated with methylation levels. Significantly, the association analysis revealed that 31 differentially expressed genes (DEGs) were targeted by methylation and miRNA and were mainly involved in the reactive oxygen species (ROS) response and abscisic acid (ABA) signaling, indicating that HS induced DNA methylation, and miRNA might affect ME by influencing ROS and ABA. This study revealed that DNA methylation and miRNA interfered with ME by modulating key genes and pathways, which could broaden our understanding of the molecular regulation of ME induced by HS pre-treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms23095147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103256PMC
May 2022

Annotating regulatory elements by heterogeneous network embedding.

Bioinformatics 2022 May;38(10):2899-2911

CEMS, NCMIS, HCMS, MADIS, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China.

Motivation: Regulatory elements (REs), such as enhancers and promoters, are known as regulatory sequences functional in a heterogeneous regulatory network to control gene expression by recruiting transcription regulators and carrying genetic variants in a context specific way. Annotating those REs relies on costly and labor-intensive next-generation sequencing and RNA-guided editing technologies in many cellular contexts.

Results: We propose a systematic Gene Ontology Annotation method for Regulatory Elements (RE-GOA) by leveraging the powerful word embedding in natural language processing. We first assemble a heterogeneous network by integrating context specific regulations, protein-protein interactions and gene ontology (GO) terms. Then we perform network embedding and associate regulatory elements with GO terms by assessing their similarity in a low dimensional vector space. With three applications, we show that RE-GOA outperforms existing methods in annotating TFs' binding sites from ChIP-seq data, in functional enrichment analysis of differentially accessible peaks from ATAC-seq data, and in revealing genetic correlation among phenotypes from their GWAS summary statistics data.

Availability And Implementation: The source code and the systematic RE annotation for human and mouse are available at https://github.com/AMSSwanglab/RE-GOA.

Supplementary Information: Supplementary data are available at Bioinformatics online.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/bioinformatics/btac185DOI Listing
May 2022

Preliminary Exploration of a Laser-Based Surface Microtexturing Strategy for Improving the Wear Resistance of Dentin: An Study.

Photobiomodul Photomed Laser Surg 2022 May;40(5):355-361

Center of Digital Dentistry, Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, NHC Research Center of Engineering and Technology for Computerized Dentistry, Beijing, P.R. China.

Herein, a feasible strategy based on a femtosecond laser (fs-laser) was provided to decelerate dentin wear, and the effect of wear resistance improvement and its potential mechanism were explored. Tooth wear is a common phenomenon that exists throughout life. While once dentin is exposed, it wears away very quickly. Decelerating tooth wear, especially dentin wear, is an important issue, but there is no ideal treatment. Sixteen third molar dentin samples were randomly divided into the amalgam (N1 = 8) and polymer infiltrated ceramic network (PICN) (N2 = 8) groups. One half of the sample was used as the experimental object and the other for the blank self-control. Array microcavities were fabricated on the experimental parts of all the samples with an fs-laser and then filled with the corresponding materials. The experimental and control parts of all the samples were subjected to 3600 cycles of sliding wear tests with titanium balls. The coefficients of friction (COFs) of every friction pair and the temperature rise were recorded in real time. The wear volume and depth were measured by a laser confocal microscopy. Statistical differences of wear volume and depth between the experimental and self-control parts were calculated by paired -test. The wear mode was observed with scanning electron microscopy (SEM). The COFs in the two experimental groups were significantly decreased. The maximum temperature rise on the dentin surface was 2.0°C. The wear resistance in the amalgam and PICN groups was 4.48 and 3.53 times higher than blank dentin, respectively ( < 0.001). The SEM images showed fewer plough grooves and cracks in dentin after microtexturing. This method could significantly improve tooth wear resistance by reducing the COFs between the friction pairs and reducing the dentin's ploughing effect and provide new treatment ideas for slowing the loss of severely worn dentin.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1089/photob.2021.0138DOI Listing
May 2022

Prediction of Oxygen Evolution Activity for NiCoFe Oxide Catalysts via Machine Learning.

ACS Omega 2022 Apr 12;7(16):14160-14164. Epub 2022 Apr 12.

Institute for Advanced Materials and Technology, University of Science and Technology Beijing, Beijing, 100083, People's Republic of China.

Transition metal (such as Fe, Co, and Ni) oxides are excellent systems in the oxygen evolution reaction (OER) for the development of non-noble-metal-based catalysts. However, direct experimental evidence and the physical mechanism of a quantitative relationship between physical factors and oxygen evolution activity are still lacking, which makes it difficult to theoretically and accurately predict the oxygen evolution activity. In this work, a data-driven method for the prediction of overpotential (OP) for (Ni-Fe-Co)O catalysts is proposed via machine learning. The physical features that are more related to the OP for the OER have been constructed and analyzed. The random forest regression model works exceedingly well on OP prediction with a mean relative error of 1.20%. The features based on first ionization energies (FIEs) and outermost d-orbital electron numbers (DEs) are the principal factors and their variances (δ and δ) exhibit a linearly decreasing correlation with OP, which gives direct guidance for an OP-oriented component design. This method provides novel and promising insights for the prediction of oxygen evolution activity and physical factor analysis in (Ni-Fe-Co)O catalysts.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.2c00776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9089339PMC
April 2022

Comparison of the Actual Diameter of Capsulotomy and Predicted Diameter of Capsulotomy after Femtosecond Laser-assisted Capsulotomy.

J Cataract Refract Surg 2022 May 12. Epub 2022 May 12.

Department of Cataract and Refractive Surgery, Clínica Baviera, Aier Eye Hospital, Bilbao, Biscay, Spain.

Purpose: To compare the consistency between the actual diameter of capsulotomy (ADC) and the predicted diameter of capsulotomy (PDC) in femtosecond laser cataract surgery(FLCS), and analyze the factors that influence the deviation of the diameter of capsulotomy (DDC) between the actual and predicted.

Setting: Aier Eye Hospital of Wuhan University, China.

Design: Retrospective observational case series.

Methods: The patients who underwent FLCS from March 2020 to March 2021 were reviewed. ADC in FLCS were measured and compared with PDC. The effects of age, gender and biometrics on DDC were analyzed.

Results: 412 eyes of 336 patients were included. The mean age was 53.0±0.91(range 3 to 91 years). When PDC was set to 4.50mm, the results showed that ADC was 5.21±0.21mm with a significant difference between them (P<0.05). However, when PDC was set to 5.2mm, ADC was 5.10±0.38mm without a significant difference between them (P>0.05). No correlation (P>0.05) was found between both: DDC and the axial length (AL), DDC and the anterior chamber depth (ACD) as well as DDC and the average keratometry (Km); but a negative correlation was found between DDC and the lens thickness (LT) (r =-0.21; P<0.05) and DDC with age (r =-0.70; P<0.05). Using curvilinear regression analysis, a development of an age-depending correction formula was predicted : ADC=PDC+1.23-0.30ln (x) (x=age ≥3) (R2 =0.65; F =752.39; P=0.00).

Conclusions: The consistency of ACD and PCD were influenced by age and LT. For patients ≤40s, the younger the patient, the wider was DDC, for patients>40s, the DDC was small. The thicker the LT, the smaller the DDC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.jcrs.0000000000000970DOI Listing
May 2022

Agreement analysis of Lenstar with other four techniques of biometry before cataract surgery.

Int Ophthalmol 2022 May 11. Epub 2022 May 11.

Department of Ophthalmology, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong, Jiangsu, China.

Purpose: To test whether some biometry measurements provided by the Lenstar LS900 compared well with the AL-Scan, Pentacam rotating Scheimpflug camera, Ultrasound Biomicroscopy (UBM) and Tomey EM-3000.

Methods: Two hundred and one patients having routine cataract surgery had standard preoperative assessment. In this clinical study, the axis length (AL) and lens thickness (LT) were taken by Lenstar LS900 and AL-Scan; anterior chamber depth (ACD) was taken by Lenstar LS900, A-Scan, Pentacam and UBM; central corneal thickness (CCT) was taken by Lenstar LS900, Pentacam and Tomey EM-3000. The results were compared using a Wilcoxon-Mann-Whitney U test and Pearson correlation calculations. Agreement was assessed through intraclass correlation coefficients and Bland-Altman plots.

Results: The highest correlation was found between Lenstar and AL-Scan for AL (r = 0.975; P < 0.001). For LT measurements, the correlation between these two devices was also good (r = 0.699; P < 0.001). Excellent correlations were showed between Lenstar and Pentacam or UBM for ACD (r = 0.948, 0.704, respectively, both P < 0.001), but not between Lenstar and AL-Scan (r = 0.453, P < 0.001). The correlations of CCT between Lenstar and Pentacam or Tomey EM-3000 were both excellent (r = 0.817, 0.882, respectively, both P < 0.001).

Conclusions: In phakic eyes of cataract patients, measurements of AL, LT, ACD and CCT from Lenstar LS900 yielded results that correlated very well with other clinical instruments.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-022-02352-zDOI Listing
May 2022

Interval estimation for nabla fractional order linear time-invariant systems.

ISA Trans 2022 Apr 27. Epub 2022 Apr 27.

Department of Advanced Design and Systems Engineering, City University of Hong Kong, Hong Kong; Center for Intelligent Multidimensional Data Analysis, Hong Kong Science Park, Shatin, Hong Kong. Electronic address:

In this paper, we provide a framework to achieve interval estimation for nabla Caputo fractional order linear time-invariant (LTI) systems in the presence of bounded model uncertainties. Interval observers based on fractional order positive systems theory are designed by possessing desired stable and positive error dynamics. Specifically, the basic concepts and conditions for guaranteeing stability and positivity of the considered systems are derived systematically by finding the system responses. Using the developed criteria and the structure of Luenberger-type observers, a classic interval observer is designed directly which further extends the system classes of interval estimation. Besides, due to the possible absence of a gain matrix which ensures positivity requirement, a more general interval observer design scheme is given by exploiting the coordinate transformation technique. Finally, some simulated cases including fault detection and fractional order circuits related scenarios are developed to validate the usefulness and practicality of the framework.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isatra.2022.04.031DOI Listing
April 2022

Brighten Triplet Excitons of Carbon Nanodots for Multicolor Phosphorescence Films.

Nano Lett 2022 May 10. Epub 2022 May 10.

Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, Key Laboratory of Material Physics, Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450001, China.

Triplet excitons usually do not emit light under ambient conditions due to the spin-forbidden transition rule, thus they are called dark excitons. Herein, triplet excitons in carbon nanodots (CNDs) are brightened by embedding the CNDs into poly(vinyl alcohol) (PVA) films; flexible multicolor phosphorescence films are thus demonstrated. PVA chains can isolate the CNDs, and excited state electron or energy transfer induced triplet exciton quenching is thus reduced; while the formed hydrogen bonds between the CNDs and PVA can restrict vibration/rotation of the CNDs, thus further protecting the triplet excitons from nonradiative recombination. The lifetimes of the flexible multicolor phosphorescence films can reach 567, 1387, 726, and 311 ms, and the longest-lasting phosphorescence film can be observed by naked eyes for nearly 15 s even after bending 5000 times. The phosphorescence films can be processed into various patterns, and a dynamic optical signature concept has been proposed and demonstrated based on the phosphorescence films.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.nanolett.2c00788DOI Listing
May 2022
-->