Publications by authors named "Yong Ma"

452 Publications

Design of a terahertz dual-channel modulator based on metamaterials.

Appl Opt 2021 Oct;60(30):9519-9524

In this paper, we propose a terahertz dual-channel modulator by combining a high electron mobility transistor (HEMT) with a metamaterials structure, in which the HEMT is embedded in the opening of the structure metamaterial. The modulator consists of a metamaterial structure, silicon carbide (SiC), HEMT active device, and feeder. The concentration of the two-dimensional electron gas (2DEG) in the HEMT can be controlled by gate voltages, and the change of the concentration can realize the modulation of the intensity and phase of the terahertz wave. The simulation results indicate that when a single channel works, the modulation depth is 90.7% at 0.22 THz and 94.0% at 0.34 THz. When both channels work, the modulation depth is 88.9% at 0.22 THz and 93.3% at 0.34 THz. The terahertz modulator designed in this paper can work in two frequency bands and can be controlled independently, which efficiently uses the spectrum resources and has broad application prospects in the field of terahertz communication.
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http://dx.doi.org/10.1364/AO.440152DOI Listing
October 2021

Magnetic CoNi alloy particles embedded N-doped carbon fibers with polypyrrole for excellent electromagnetic wave absorption.

J Colloid Interface Sci 2021 Oct 6. Epub 2021 Oct 6.

School of Civil Engineering, Qingdao University of Technology, Qingdao 266033, People's Republic of China.

Increasing electromagnetic (EM) radiation has driven the rapid development of carbon-based EM wave absorption materials, but the design of light-weight and efficient carbon-based materials remains a huge challenge. Herein, N-doped carbon fibers embedded with CoNi alloy particles (CoNi/C fibers) were synthesized via electrospinning technology and carbonization. Then, conductive polypyrrole-coated CoNi/C fibers (CoNi/[email protected] composites) were synthesized by chemical polymerization. As-synthesized CoNi/[email protected] composites showed outstanding EM wave absorption property due to the synergistic effect between CoNi, N-doped carbon fibers and PPy. The optimal reflection loss (RL) is -68.78 dB (12.90 GHz) with the thickness of 2.43 mm and the low filler loading of 15 wt%. The widest effective absorption bandwidth (EAB) is 5.62 GHz with the thickness of 2.10 mm and the low filler loading of 20 wt%. The outstanding EM wave absorption property is mainly attributed to 3D network structure, great impedance matching and strong dielectric loss. The results showed that embedding magnetic alloy particles in carbon fibers coated with conductive polymers is an effective strategy for constructing efficient lightweight EM wave absorption materials.
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http://dx.doi.org/10.1016/j.jcis.2021.10.006DOI Listing
October 2021

Use of Traditional Chinese Medicine and Its Impact on Medical Cost among Urban Ischemic Stroke Inpatients in China: A National Cross-Sectional Study.

Evid Based Complement Alternat Med 2021 29;2021:8554829. Epub 2021 Oct 29.

School of Management, Beijing University of Chinese Medicine, Beijing, China.

Background: Traditional Chinese medicine (TCM) has long been widely adopted by the Chinese people and has been covered by China's basic medical insurance schemes to treat ischemic stroke. Previous research has mainly highlighted the therapy effect of TCM on ischemic stroke patients. Some studies have demonstrated that employing TCM can reduce the medical burden on other diseases. But no research has explored whether using TCM could reduce inpatient medical cost for ischemic stroke in mainland China. The purpose of this study is to investigate the impact of the use of TCM on the total inpatient cost of ischemic stroke and to explore whether TCM has played the role of being complementary to, or an alternative for, conventional medicine to treat ischemic stroke.

Methods: We conducted a national cross-sectional analysis based on a 5% random sample from claims data of China Urban Employee Basic Medical Insurance (UEBMI) and Urban Resident Basic Medical Insurance (URBMI) schemes in 2015. Mann-Whitney test was used to compare unadjusted total inpatient cost, conventional medication cost, and nonpharmacy cost estimates. Ordinary least square regression analysis was performed to compare demographics-adjusted total inpatient cost and to examine the association between TCM cost and conventional medication cost.

Results: A total of 47321 urban inpatients diagnosed with ischemic stroke were identified in our study, with 92.6% (43843) of the patients using TCM in their inpatient treatment. Total inpatient cost for TCM users was significantly higher than TCM nonusers (USD 1217 versus USD 1036, < 0.001). Conventional medication cost was significantly lower for TCM users (USD 335 versus USD 436, < 0.001). The average cost of TCM per patient among TCM users was USD 289. Among TCM users, conventional medication costs were found to be positively associated with TCM cost after adjusting for confounding factors (Coef. = 0.144, < 0.001).

Conclusion: Although the use of TCM reduced the cost of conventional medicine compared with TCM nonusers, TCM imposed an extra financial component on the total inpatient cost on TCM users. Our study suggests that TCM mainly played a complementary role to conventional medicine in ischemic stroke treatment in mainland China.
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http://dx.doi.org/10.1155/2021/8554829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570870PMC
October 2021

Ganoderic Acid A Attenuates IL-1β-Induced Inflammation in Human Nucleus Pulposus Cells Through Inhibiting the NF-κB Pathway.

Inflammation 2021 Nov 5. Epub 2021 Nov 5.

Orthopedics Department, Foshan Nanhai District Fifth People's Hospital, Nanhai District, No. 63, Zhongbian Road, Dali TownFoshanGuangdong Province, 528231, China.

Intervertebral disc (IVD) degeneration is a major cause of low back pain associated with several pathological changes in the IVD, including dysfunction of nucleus pulposus (NP) cells. Ganoderic Acid A (GAA), one of triterpenoid extracts of Ganoderma lucidum (G. lucidum), has been reported to possess anti-inflammatory effect. In the current study, we aimed to evaluate the effect of Ganoderic Acid A (GAA) on the interleukin-1β (IL-1β)-induced inflammation in human NP cells. Our results showed that the IL-1β-stimulated production of inflammatory mediators including nitric oxide (NO), prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were suppressed by GAA. In addition, treatment of NP cells with GAA significantly inhibited the production of inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in IL-1β-stimulated human NP cells. GAA improved the reduced expression levels of extracellular matrix (ECM) proteins, collagen II and aggrecan in IL-1β-stimulated human NP cells. GAA also alleviated IL-1β-induced the levels of matrix metalloproteinase (MMP)-3 and MMP-13. Furthermore, GAA inhibited the IL-1β-induced upregulation of the phosphorylation of p65 and downregulation of IκBα. Taken together, these findings indicated that GAA alleviated IL-1β-induced inflammation and ECM degradation in NP cells through regulating NF-κB pathway.
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http://dx.doi.org/10.1007/s10753-021-01590-0DOI Listing
November 2021

Molybdenum Selenide/Porous Carbon Nanomaterial Heterostructures with Remarkably Enhanced Light-Boosting Peroxidase-like Activities.

ACS Appl Mater Interfaces 2021 Nov 3;13(45):54274-54283. Epub 2021 Nov 3.

School of Energy and Power Engineering & School of Material Science and Engineering, North University of China, Taiyuan 030051, P. R. China.

Nanozymes have emerged as a fascinating nanomaterial with enzyme-like characteristics for addressing the limitations of natural enzymes. Nevertheless, how to improve the relatively low catalytic activity still remains challenging. Herein, a facile recrystallizing salt template-assisted chemical vapor deposition method was utilized to synthesize MoSe/PCN heterostructures. This heterostructure displays remarkably enhanced light boosting peroxidase-like activities. Notably, the maximal reaction velocity of this heterostructure attains 17.81 and 86.89 μM min [for -phenylenediamine (OPD) and 3,3'5,5'-tetramethylbenzidine (TMB), respectively]. Moreover, various characterization means were performed to explore the mechanism deeply. It is worth mentioning that the photoinduced electrons generated by the heterostructure directly react with HO to yield plentiful OH for the effective oxidation of OPD and TMB. Therefore, this work offers a promising approach for improving peroxidase-like activity by light stimulation and actuating the development of enzyme-based applications.
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http://dx.doi.org/10.1021/acsami.1c16569DOI Listing
November 2021

Dispatched uses Na flux to power release of lipid-modified Hedgehog.

Nature 2021 11 27;599(7884):320-324. Epub 2021 Oct 27.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.

The Dispatched protein, which is related to the NPC1 and PTCH1 cholesterol transporters and to H-driven transporters of the RND family, enables tissue-patterning activity of the lipid-modified Hedgehog protein by releasing it from tightly -localized sites of embryonic expression. Here we determine a cryo-electron microscopy structure of the mouse protein Dispatched homologue 1 (DISP1), revealing three Na ions coordinated within a channel that traverses its transmembrane domain. We find that the rate of Hedgehog export is dependent on the Na gradient across the plasma membrane. The transmembrane channel and Na binding are disrupted in DISP1-NNN, a variant with asparagine substitutions for three intramembrane aspartate residues that each coordinate and neutralize the charge of one of the three Na ions. DISP1-NNN and variants that disrupt single Na sites retain binding to, but are impaired in export of the lipid-modified Hedgehog protein to the SCUBE2 acceptor. Interaction of the amino-terminal signalling domain of the Sonic hedgehog protein (ShhN) with DISP1 occurs via an extensive buried surface area and contacts with an extended furin-cleaved DISP1 arm. Variability analysis reveals that ShhN binding is restricted to one extreme of a continuous series of DISP1 conformations. The bound and unbound DISP1 conformations display distinct Na-site occupancies, which suggests a mechanism by which transmembrane Na flux may power extraction of the lipid-linked Hedgehog signal from the membrane. Na-coordinating residues in DISP1 are conserved in PTCH1 and other metazoan RND family members, suggesting that Na flux powers their conformationally driven activities.
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http://dx.doi.org/10.1038/s41586-021-03996-0DOI Listing
November 2021

Single-Cell Analysis of the In Vivo Dynamics of Host Circulating Immune Cells Highlights the Importance of Myeloid Cells in Avian Flaviviral Infection.

J Immunol 2021 12 25;207(11):2878-2891. Epub 2021 Oct 25.

State Key Laboratory of Veterinary Biotechnology, National Poultry Laboratory Animal Resource Center, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China; and

Ducks are an economically important waterfowl but a natural reservoir for some zoonotic pathogens, such as influenza virus and flaviviruses. Our understanding of the duck immune system and its interaction with viruses remains incomplete. In this study, we constructed the transcriptomic landscape of duck circulating immune cells, the first line of defense in the arthropod-borne transmission of arboviruses, using high-throughput single-cell transcriptome sequencing, which defined 14 populations of peripheral blood leukocytes (PBLks) based on distinct molecular signatures and revealed differences in the clustering of PBLks between ducks and humans. Taking advantage of in vivo sex differences in the susceptibility of duck PBLks to avian tembusu virus (TMUV) infection, a mosquito-borne flavivirus newly emerged from ducks with a broad host range from mosquitos to mammals, a comprehensive comparison of the in vivo dynamics of duck PBLks upon TMUV infection between sexes was performed at the single-cell level. Using this in vivo model, we discovered that TMUV infection reprogrammed duck PBLks differently between sexes, driving the expansion of granulocytes and priming granulocytes and monocytes for antiviral immune activation in males but decreasing the antiviral immune activity of granulocytes and monocytes by restricting their dynamic transitions from steady states to antiviral states with a decrease in the abundance of circulating monocytes in females. This study provides insights into the initial immune responses of ducks to arthropod-borne flaviviral infection and provides a framework for studying duck antiviral immunity.
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http://dx.doi.org/10.4049/jimmunol.2100116DOI Listing
December 2021

Insufficient procedural anticoagulation during leadless pacing led to catheter-related thrombosis in a hemodialysis patient.

BMC Cardiovasc Disord 2021 10 18;21(1):502. Epub 2021 Oct 18.

Department of Cardiology, The Sixth Medical Center of Chinese PLA General Hospital, 6th, Fucheng Road, Haidian District, Beijing, 100853, People's Republic of China.

Background: Leadless pacemaker was a promising innovation than traditional transvenous pacemaker, the procedural complications were prone to be bleeding-related. However, very few reports also concerned about the thrombus formation during the procedure.

Case Presentation: A hemodialysis patient with diabetic gangrene of right foot suffered from catheter-related thrombosis during leadless pacing, resulting in failure of recapture the pacemaker. A low activated clotting time (ACT) level of 104 s confirmed the insufficiency of anticoagulation. Finally, the whole delivery catheter had to be removed from the delivery sheath, another new pacemaker system was applied and successfully implanted after adjusting the ACT level to 248 s.

Conclusion: Catheter-related thrombosis could be a large obstacle for leadless pacemaker implantation. In addition to routine anticoagulation, ACT monitoring might be necessary during the procedure.
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http://dx.doi.org/10.1186/s12872-021-02318-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8522239PMC
October 2021

Smoothness-Driven Consensus Based on Compact Representation for Robust Feature Matching.

IEEE Trans Neural Netw Learn Syst 2021 Oct 18;PP. Epub 2021 Oct 18.

For robust feature matching, a popular and particularly effective method is to recover smooth functions from the data to differentiate the true correspondences (inliers) from false correspondences (outliers). In the existing works, the well-established regularization theory has been extensively studied and exploited to estimate the functions while controlling its complexity to enforce the smoothness constraint, which has shown prominent advantages in this task. However, despite the theoretical optimality properties, the high complexities in both time and space are induced and become the main obstacle of their application. In this article, we propose a novel method for multivariate regression and point matching, which exploits the sparsity structure of smooth functions. Specifically, we use compact Fourier bases for constructing the function, which inherently allows a coarse-to-fine representation. The smoothness constraint can be explicitly imposed by adopting a few low-frequency bases for representation, resulting in reduced computational complexities of the induced multivariate regression algorithm. To cope with potential gross outliers, we formulate the learning problem into a Bayesian framework with latent variables indicating the inliers and outliers and a mixture model accounting for the distribution of data, where a fast expectation-maximization solution can be derived. Extensive experiments are conducted on synthetic data and real-world image matching, and point set registration datasets, which demonstrates the advantages of our method against the current state-of-the-art methods in terms of both scalability and robustness.
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http://dx.doi.org/10.1109/TNNLS.2021.3118409DOI Listing
October 2021

Facile fabrication of metal-organic framework derived Fe/FeO/FeN/N-doped carbon composites coated with PPy for superior microwave absorption.

J Colloid Interface Sci 2021 Sep 29;608(Pt 1):525-535. Epub 2021 Sep 29.

School of Civil Engineering, Qingdao University of Technology, Qingdao 266033, People's Republic of China.

At present, the magnetic metal/carbon composites have been widely explored for microwave absorption (MA), which effectively integrate the characteristics of magnetic and dielectric materials. As a typical material, metal-organic framework (MOF) shows tremendous potential as a precursor or template. However, its development is limited by the inferior impedance matching. Herein, a novel rod-like Fe/FeO/FeN/N-doped carbon (FON/NC) composite was synthesized via dual-ligand strategy and following calcination. The outer polypyrrole (PPy) shell, obtained by a facile polymerization method, effectively optimized the impedance matching and observably enhanced the MA capacity. Both the multi-component loss mechanism and unique porous core-shell structures of MOF-derived composites were beneficial for microwave attenuation. The effects of filler loadings (20 wt%, 25 wt%, 30 wt% and 35 wt%) on electromagnetic (EM) properties of FON/[email protected] composites were discussed. Remarkably, as-obtained composites exhibited a minimum reflection loss (RL) value of -60.08 dB at the layer thickness of merely 1.44 mm and the widest effective absorption bandwidth (EAB, RL ≤ -10 dB) of 5.06 GHz at 1.64 mm with 30 wt% filler loading. This work provides a great reference for designing MOF-derived absorbers with high MA performance.
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http://dx.doi.org/10.1016/j.jcis.2021.09.169DOI Listing
September 2021

Adversarial Autoencoder Network for Hyperspectral Unmixing.

IEEE Trans Neural Netw Learn Syst 2021 Oct 8;PP. Epub 2021 Oct 8.

Spectral unmixing (SU), which refers to extracting basic features (i.e., endmembers) at the subpixel level and calculating the corresponding proportion (i.e., abundances), has become a major preprocessing technique for the hyperspectral image analysis. Since the unmixing procedure can be explained as finding a set of low-dimensional representations that reconstruct the data with their corresponding bases, autoencoders (AEs) have been effectively designed to address unsupervised SU problems. However, their ability to exploit the prior properties remains limited, and noise and initialization conditions will greatly affect the performance of unmixing. In this article, we propose a novel technique network for unsupervised unmixing which is based on the adversarial AE, termed as adversarial autoencoder network (AAENet), to address the above problems. First, the image to be unmixed is assumed to be partitioned into homogeneous regions. Then, considering the spatial correlation between local pixels, the pixels in the same region are assumed to share the same statistical properties (means and covariances) and abundance can be modeled to follow an appropriate prior distribution. Then the adversarial training procedure is adapted to transfer the spatial information into the network. By matching the aggregated posterior of the abundance with a certain prior distribution to correct the weight of unmixing, the proposed AAENet exhibits a more accurate and interpretable unmixing performance. Compared with the traditional AE method, our approach can greatly enhance the performance and robustness of the model by using the adversarial procedure and adding the abundance prior to the framework. The experiments on both the simulated and real hyperspectral data demonstrate that the proposed algorithm can outperform the other state-of-the-art methods.
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http://dx.doi.org/10.1109/TNNLS.2021.3114203DOI Listing
October 2021

and Alleviate Intestinal Inflammation and Microbial Disorder Induced by ETEC in a Murine Model.

Oxid Med Cell Longev 2021 21;2021:6867962. Epub 2021 Sep 21.

College of Bioscience and Biotechnology, Hunan Agricultural University, Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, Changsha, Hunan 410125, China.

The purpose of this research is to explore the positive effects of and on the tissue damage and microbial community in mice challenged by Enterotoxigenic (ETEC). Twenty-four mice were divided into four groups randomly: the CON group, ETEC group, LP-ETEC group and LB-ETEC group. Our results demonstrated that, compared with the ETEC group, the LP-ETEC and LB-ETEC groups experienced less weight loss and morphological damage of the jejunum. We measured proinflammatory factors of colonic tissue and found that and inhibited the expression of proinflammatory factors such as IL-, TNF-, and IL-6 and promoted that of the tight junction protein such as claudin-1, occludin, and ZO-1. Additionally, and altered the impact of ETEC on the intestinal microbial community of mice, significantly increased the abundance of probiotics such as , and reduced that of pathogenic bacteria such as , , , and . Therefore, we believe that and can stabilize the intestinal microbiota and inhibit the growth of pathogenic bacteria, thus protecting mice from the gut inflammation induced by ETEC.
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http://dx.doi.org/10.1155/2021/6867962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478549PMC
September 2021

Comprehensive analysis of the transcriptional expressions and prognostic value of S100A family in pancreatic ductal adenocarcinoma.

BMC Cancer 2021 Sep 16;21(1):1039. Epub 2021 Sep 16.

Department of General Surgery, Gansu Provincial Cancer Hospital Lanzhou University Second Hospital, No.82 Cui-ying Men, Lanzhou, 730030, Gansu Province, China.

Background: Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory malignancy with poor prognosis. It is urgent to identify novel and valid biomarkers to predict the progress and prognosis of PDAC. The S100A family have been identified as being involved in cell proliferation, migration and differentiation progression of various cancer types. However, the expression patterns and prognostic values of S100As in PDAC remain to be analyzed.

Methods: We investigated the transcriptional expressions, methylation level and prognostic value of S100As in PDAC patients from the Oncomine, GEPIA2, Linkedomics and cBioPortal databases. Real-time PCR was used to detect the expressions of S100A2/4/6/10/14/16 in four pancreatic cancer cell lines and pancreatic cancer tissues from PDAC patients undergoing surgery. To verify the results further, immunohistochemistry was used to measure the expression of S100A2/4/6/10/14/16 in 43 PDAC patients' tissue samples. The drug relations of S100As were analyzed by using the Drugbank database.

Results: The results suggested that, the expression levels of S100A2/4/6/10/14/16 were elevated to PDAC tissues than in normal pancreatic tissues, and the promoter methylation levels of S100A S100A2/4/6/10/14/16 in PDAC (n = 10) were lower compared with normal tissue (n = 184) (P < 0.05). In addition, their expressions were negatively correlated with PDAC patient survival.

Conclusions: Taken together, these results suggest that S100A2/4/6/10/14/16 might be served as prognostic biomarkers for survivals of PDAC patients.
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http://dx.doi.org/10.1186/s12885-021-08769-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447682PMC
September 2021

Integrative Analysis of the Roles of lncRNAs and mRNAs in Itaconate-Mediated Protection Against Liver Ischemia-Reperfusion Injury in Mice.

J Inflamm Res 2021 8;14:4519-4536. Epub 2021 Sep 8.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of Hepatic Minimal Invasive Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People's Republic of China.

Purpose: Itaconate is well known for its strong anti-inflammatory and antioxidant effect, but little is known about the potential role of long non-coding RNAs (lncRNAs) in the underlying mechanisms of hepatic ischemia-reperfusion (IR) injury. The aim of our study is to identify lncRNAs related to IR injury and itaconate-mediated protection and to demonstrate the mechanism by which itaconate acts in liver IR injury from the new perspective of lncRNAs.

Methods: 4-Octyl itaconate (OI), a membrane-permeable derivative of itaconate, was used as a substitute for itaconate in our study. By using a mouse model of hepatic IR injury, serum and liver samples were collected to measure indexes of liver injury. Then, the liver samples of the mice were subjected to RNA sequencing (RNA-seq) and subsequent bioinformatics analysis.

Results: Itaconate attenuated liver IR injury. A total of 138 lncRNAs and 156 messenger RNAs (mRNAs) were markedly differentially expressed in the IR-damaged liver tissues pretreated with OI compared with the matched liver tissues treated with vehicle. Functional analysis indicated that lncRNAs may indirectly participate in the effects of itaconate. Furthermore, 41 mRNAs were examined for the protein-protein interaction (PPI) network analysis, and a key gene cluster was defined. Then, combined the coexpression analysis and the and regulatory function prediction of lncRNAs, some "candidate" lncRNA-mRNA pairs which might relate to itaconate-mediated liver protection were identified, while the relationship requires future validation.

Conclusion: Our study revealed that itaconate could protect the liver against IR injury and that lncRNAs might play a role in this process. Our study provides a novel way to investigate the mechanism by which itaconate affects hepatic IR injury and exerts its anti-inflammatory and antioxidative stress effects.
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http://dx.doi.org/10.2147/JIR.S327467DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8435882PMC
September 2021

Leveraging Case Narratives to Enhance Patient Age Ascertainment from Adverse Event Reports.

Pharmaceut Med 2021 09 2;35(5):307-316. Epub 2021 Sep 2.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida, Gainesville, FL, USA.

Introduction: Missing age presents a significant challenge when evaluating individual case safety reports (ICSRs) in the FDA Adverse Event Reporting System (FAERS). When age is missing in an ICSR's structured field, it may be in the report's free-text narrative.

Objectives: This study aimed to evaluate the performance and assess the potential impact of a rule-based natural language processing (NLP) tool that utilizes a text string search to identify patients' numerical age from unstructured narratives.

Methods: Using FAERS ICSRs from 2002 to 2018, we evaluated the annual proportion of ICSRs with age missing in the structured field before and after NLP application. Reviewers manually identified patients' age from ICSR narratives (gold standard) from a random sample of 1500 ICSRs. The gold standard was compared to the NLP-identified age.

Results: During the study period, the percentage of ICSRs missing age in the structured field increased from 21.9 to 43.8%. The NLP tool performed well among the random sample: sensitivity 98.5%, specificity 92.9%, positive predictive value (PPV) 94.9%, and F-measure 96.7%. It also performed well for the subset of ICSRs missing age in the structured field; when applied to these cases, NLP identified age for an additional one million ICSRs (10% of the total number of ICSRs from 2002 to 2018) and decreased the percentage of ICSRs missing age to 27% overall.

Conclusions: NLP has potential utility to extract patients' age from ICSR narratives. Use of this tool would enhance pharmacovigilance and research using FAERS data.
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http://dx.doi.org/10.1007/s40290-021-00398-5DOI Listing
September 2021

Insulative Ion-Conducting Lithium Selenide as the Artificial Solid-Electrolyte Interface Enabling Heavy-Duty Lithium Metal Operations.

Nano Lett 2021 Sep 27;21(17):7354-7362. Epub 2021 Aug 27.

Soochow Institute for Energy and Materials Innovations, College of Energy, Soochow University, Suzhou 215006, P.R. China.

The deployment of Li metal batteries has been significantly tethered by uncontrollable lithium dendrite growth, especially in heavy-duty operations. Herein, we implement an surface transformation tactic exploiting the vapor-phase solid-gas reaction to construct an artificial solid-electrolyte interphase (SEI) of LiSe on Li metal anodes. The conformal LiSe layer with high ionic diffusivity but poor electron conductivity effectively restrains the Li/Li redox conversion to the Li/LiSe interface, and further renders a smooth and chunky Li deposition through homogenized Li flux and promoted redox kinetics. Consequently, the as-fabricated [email protected] electrodes demonstrate superb cycling stability in symmetric cells at both high capacity and current density. The merits of inhibited dendrite growth and side reactions on the stabilized [email protected] anode are further manifested in Li-O batteries, greatly extending the cycling stability and energy efficiency.
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http://dx.doi.org/10.1021/acs.nanolett.1c02658DOI Listing
September 2021

Pairwise Elastic Net Representation-Based Classification for Hyperspectral Image Classification.

Entropy (Basel) 2021 Jul 26;23(8). Epub 2021 Jul 26.

School of Mathematics and Computer Science, Wuhan Polytechnic University, Wuhan 430023, China.

The representation-based algorithm has raised a great interest in hyperspectral image (HSI) classification. l1-minimization-based sparse representation (SR) attempts to select a few atoms and cannot fully reflect within-class information, while l2-minimization-based collaborative representation (CR) tries to use all of the atoms leading to mixed-class information. Considering the above problems, we propose the pairwise elastic net representation-based classification (PENRC) method. PENRC combines the l1-norm and l2-norm penalties and introduces a new penalty term, including a similar matrix between dictionary atoms. This similar matrix enables the automatic grouping selection of highly correlated data to estimate more robust weight coefficients for better classification performance. To reduce computation cost and further improve classification accuracy, we use part of the atoms as a local adaptive dictionary rather than the entire training atoms. Furthermore, we consider the neighbor information of each pixel and propose a joint pairwise elastic net representation-based classification (J-PENRC) method. Experimental results on chosen hyperspectral data sets confirm that our proposed algorithms outperform the other state-of-the-art algorithms.
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http://dx.doi.org/10.3390/e23080956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8392166PMC
July 2021

MoS decorated on one-dimensional MgFeO/MgO/C composites for high-performance microwave absorption.

J Colloid Interface Sci 2022 Jan 11;606(Pt 1):709-718. Epub 2021 Aug 11.

School of Civil Engineering, Qingdao University of Technology, Qingdao 266033, People's Republic of China.

Advanced microwave absorption (MA) materials have attracted widespread attention to meet the challenges of electromagnetic (EM) pollution. Herein, MgFeO/MgO/C fibers were successfully prepared via electrospinning technology and carbonization, and their surfaces were coated by MoS via hydrothermal method. The EM wave absorption performance of composites was enhanced due to the introduction of MoS. The results showed that the EM wave absorption performance of MgFeO/MgO/C could not meet the requirements due to low dielectric loss and poor impedance matching. The performance of the composites was improved after coating of MoS, which showed the strong wave absorption capability and the broad absorption bandwidth. The optimal reflection loss (RL) is -56.94 dB at 9.5 GHz and the effective absorption bandwidth is 3.9 GHz (8.08-11.98 GHz) with a thickness of 2.7 mm. The excellent MA performance can be mainly attributed to excellent synergistic effect between MgFeO/MgO/C and MoS. Furthermore, MoS also contributes to dielectric loss and ideal impedance matching. MgFeO/MgO/[email protected] composites may be utilized for lightweight and high-efficient MA materials.
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http://dx.doi.org/10.1016/j.jcis.2021.08.056DOI Listing
January 2022

Fabrication of one-dimensional CoFe/[email protected] composites as efficient electromagnetic wave absorption materials.

Dalton Trans 2021 Sep 6;50(33):11640-11649. Epub 2021 Aug 6.

School of Civil Engineering, Qingdao University of Technology, Qingdao 266033, People's Republic of China.

New types of electromagnetic (EM) wave absorption materials with a light weight, strong absorption ability and wide absorption frequency have been widely explored. Nevertheless, it is still an intractable challenge to design the structure of the materials and rationalize multiple components. In this work, one-dimensional (1D) CoFe/[email protected] composites were prepared via electrospinning technology, high-temperature carbonization and hydrothermal method. SEM and TEM images reveal that the as-prepared CoFe/C fibers with a 1D structure are well coated with MoS. The excellent absorption performance of the composites is mainly attributed to the 1D structure and the ideal impedance matching. CoFe/[email protected] composites show strong absorption ability with an optimal reflection loss (RL) of -66.8 dB (13.28 GHz) at a matching thickness of 2.12 mm. Meanwhile, the composite possesses an effective absorption frequency range between 10.70 and 16.02 GHz with a bandwidth of 5.32 GHz. These results indicate that CoFe/[email protected] composites will become promising lightweight and highly efficient MA materials.
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http://dx.doi.org/10.1039/d1dt01915eDOI Listing
September 2021

Prevalence and Risk Factor Analysis of Constipation After Thoracolumbar Vertebral Compression Fractures.

Int J Gen Med 2021 30;14:4117-4123. Epub 2021 Jul 30.

Department of Rehabilitation & Acupuncture, Wuxi People's Hospital Affiliated Nanjing Medical University, Wuxi, 214023, People's Republic of China.

Objective: To analyze the prevalence and risk factors of constipation after thoracolumbar vertebral compression fractures (TVCFs).

Methods: This retrospective study reviews the records of patients hospitalized between January 1, 2017 and December 31, 2018 with TVCFs. A total of 117 patient's records are included (n = 117). Univariate and multivariate analysis using the logistic regression method are carried out to identify the prevalence and potential risk factors for constipation after TVCF, including gender, age, number of fractured vertebrae, major segment of vertebral fracture, degree of compression, use of painkillers, diabetes, and the intervention of Zengyechengqi decoction.

Results: Among the 117 patients with TVCFs that were included in this study, 83 (70.9%) patients developed constipation. Univariate analysis showed that the factors of degree of vertebral compression and the preintervention of Zengyechengqi decoction had statistically significant effects on the incidence of constipation after TVCF (P < 0.05), indicating that they might contribute to the incidence of constipation after TVCF. Multivariate logistic regression analysis showed that degree of vertebral compression was a risk factor (P < 0.05), while preintervention of Zengyechengqi decoction was a protective factor (P < 0.05), for constipation after TVCF.

Conclusion: Patients with vertebral fractures featuring a higher degree of compression may have a higher risk of constipation. Preintervention of Zengyechengqi decoction can reduce the incidence of constipation after TVCF.
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http://dx.doi.org/10.2147/IJGM.S320953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331197PMC
July 2021

One-dimensional [email protected]/[email protected] composites for superior electromagnetic wave absorption.

J Colloid Interface Sci 2022 Jan 16;605:483-492. Epub 2021 Jul 16.

Institute of Materials for Energy and Environment, State Key Laboratory of Bio-fibers and Eco-textiles, College of Materials Science and Engineering, Qingdao University, Qingdao 266071, People's Republic of China.

The conductive networks for electron hopping and migration constructed by one-dimensional (1D) composite absorbers are highly desirable to improve the electromagnetic (EM) wave attenuation capacity. Herein, the [email protected]/[email protected] (PPy) composites integrating the advantages of component and microstructure were fabricated. The addition of Co/C and PPy effectively optimized the impedance matching and improved the EM attenuation. Under the comprehensive impacts of multiple reflections/scattering, conduction loss and interface polarization, the [email protected]/[email protected] composites showed superior EM wave absorption with the reflection loss (RL) value of -48.76 dB and the effective absorption bandwidth (EAB) of 5.10 GHz at a corresponding thickness of 2.0 mm. The largest EAB could reach 5.54 GHz (7.24-12.78 GHz) at the thickness of 2.2 mm. This work provides a great reference for fabricating 1D novel EM wave absorption materials.
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http://dx.doi.org/10.1016/j.jcis.2021.07.050DOI Listing
January 2022

Sporadic hemangioblastoma of the kidney: a clinicopathologic study of three cases and a literature review.

J Int Med Res 2021 Jul;49(7):3000605211027774

Department of Pathology, Tai'an Central Hospital, Tai'an, China.

Much attention has been paid to renal hemangioblastoma, but there are still challenges in its differential diagnosis. Three cases (2 men, 1 woman; age: 40-56 years) presented with renal tumors. The tumors were surrounded by a thick fibrous capsule, well-demarcated from the surrounding renal parenchyma, and composed of sheets or nests of polygonal to short spindle-shaped tumor cells with a rich capillary network. In cases 1 and 3, the large polygonal tumor cells contained abundant pale or eosinophilic cytoplasm, and some possessed intracytoplasmic lipid vacuoles. In case 2, tumor cells were characterized by a uniform size, mild, clear, or lightly stained cytoplasm, and typical "clear cell" appearance. Immunohistochemistry revealed that the polygonal stromal cells were strongly and diffusely positive for α-inhibin, neuron-specific enolase (NSE), S100 protein, and vimentin. Cluster of differentiation (CD)10 and paired box gene (PAX)8 were positive, while epithelial membrane antigen (EMA) and cytokeratin (CK) were focally positive in case 3. CD34 and CD31 outlined the contours and distribution of the vascular networks. Renal hemangioblastoma is rare and prone to misdiagnosis; more attention should be paid to the morphological features and reasonable application of immunohistochemistry in the diagnosis of hemangioblastoma.
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http://dx.doi.org/10.1177/03000605211027774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283055PMC
July 2021

Fabrication of ZnFeO/[email protected] composites with efficient electromagnetic wave absorption properties.

J Colloid Interface Sci 2021 Nov 10;602:602-611. Epub 2021 Jun 10.

School of Material Science and Engineering, Shandong University of Science and Technology, Qingdao 266590, People's Republic of China.

Nowadays, ferrites/carbon fibers have attracted considerable attention as microwave absorption materials (MA) due to the synergistic effect between dielectric and magnetic loss. Herein, the ZnFeO/C fibers were fabricated via electrospinning and calcination methods, and then polypyrrole (PPy) successfully coated on the fibers via oxidative polymerization. The ZnFeO/[email protected] composites exhibit enhanced EM wave absorption performance with the loading of 25 wt%. The optimal reflection loss (RL) value is up to -66.34 dB (13.80 GHz) and effective absorption bandwidth (EAB) is 5.74 GHz (11.78-17.52 GHz) with a matching thickness of 1.93 mm. Besides, high-efficient absorption performance of the ZnFeO/[email protected] composites is mainly attributed to the dielectric loss and ideal impedance matching. This study reveals a novel approach to development of ferrites/carbon fibers coated with PPy, and the ZnFeO/[email protected] composites exhibit great potential application as the materials with high-efficient absorption properties.
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http://dx.doi.org/10.1016/j.jcis.2021.06.042DOI Listing
November 2021

PGC-1 Protects against Hepatic Ischemia Reperfusion Injury by Activating PPAR and PPAR and Regulating ROS Production.

Oxid Med Cell Longev 2021 19;2021:6677955. Epub 2021 May 19.

Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Peroxisome proliferator-activated receptors (PPARs) and have been shown to be protective in hepatic ischemia/reperfusion (I/R) injury. However, the precise role of PPAR coactivator-1 (PGC-1), which can coactivate both of these receptors, in hepatic I/R injury, remains largely unknown. This study was designed to test our hypothesis that PGC-1 is protective during hepatic I/R injury in vitro and in vivo. Our results show that endogenous PGC-1 is basally expressed in normal livers and is moderately increased by I/R. Ectopic PGC-1 protects against hepatic I/R and hepatocyte anoxia/reoxygenation (A/R) injuries, whereas knockdown of endogenous PGC-1 aggravates such injuries, as evidenced by assessment of the levels of serum aminotransferases and inflammatory cytokines, necrosis, apoptosis, cell viability, and histological examination. The EMSA assay shows that the activation of PPAR and PPAR is increased or decreased by the overexpression or knockdown of PGC-1, respectively, during hepatic I/R and hepatocyte A/R injuries. In addition, the administration of specific antagonists of either PPAR (MK886) or PPAR (GW9662) can effectively decrease the protective effect of PGC-1 against hepatic I/R and hepatocyte A/R injuries. We also demonstrate an important regulatory role of PGC-1 in reactive oxygen species (ROS) metabolism during hepatic I/R, which is correlated with the induction of ROS-detoxifying enzymes and is also dependent on the activations of PPAR and PPAR. These data demonstrate that PGC-1 protects against hepatic I/R injury, mainly by regulating the activation of PPAR and PPAR. Thus, PGC-1 may be a promising therapeutic target for the protection of the liver against I/R injury.
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http://dx.doi.org/10.1155/2021/6677955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159639PMC
May 2021

Ru-Embedded Highly Porous Carbon Nanocubes Derived from Metal-Organic Frameworks for Catalyzing Reversible LiO Formation.

ACS Appl Mater Interfaces 2021 Jun 8;13(24):28295-28303. Epub 2021 Jun 8.

Soochow Institute for Energy and Materials Innovations, College of Energy, Soochow University, Suzhou 215006, China.

Rechargeable lithium-oxygen batteries (LOBs) have attracted increasing attention due to their high energy density but highly rely on the development of efficient oxygen catalysts for reversible LiO deposition/decomposition. Herein, highly porous carbon nanocubes with a specific surface area up to 1600 m g are synthesized and utilized to tightly anchor Ru nanoparticles for using as the oxygen-cathode catalyst in LOBs, achieving a low charge/discharge potential gap of only 0.75 V, a high total discharge capacity of 17,632 mA h g, and a superb cycling performance of 550 cycles at 1000 mA g. Comprehensive ex situ and operando characterizations unravel that the outstanding LOB performance is ascribed to the highly porous catalyst structure embedding rich active sites that synergistically function in reducing overpotentials, suppressing parasitic reactions, accommodating reaction products, and promoting mass and charge transportation.
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http://dx.doi.org/10.1021/acsami.1c06572DOI Listing
June 2021

Wax-Transferred Hydrophobic CVD Graphene Enables Water-Resistant and Dendrite-Free Lithium Anode toward Long Cycle Li-Air Battery.

Adv Sci (Weinh) 2021 Aug 3;8(16):e2100488. Epub 2021 Jun 3.

Center for Nanochemistry (CNC), Beijing Science and Engineering Center for Nanocarbons, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China.

One of the key challenges in achieving practical lithium-air battery is the poor moisture tolerance of the lithium metal anode. Herein, guided by theoretical modeling, an effective tactic for realizing water-resistant Li anode by implementing a wax-assisted transfer protocol is reported to passivate the Li surface with an inert high-quality chemical vapor deposition (CVD) graphene layer. This electrically conductive and mechanically robust graphene coating enables serving as an artificial solid/electrolyte interphase (SEI), guiding homogeneous Li plating/stripping, suppressing dendrite and "dead" Li formation, as well as passivating the Li surface from moisture erosion and side reactions. Consequently, lithium-air batteries fabricated with the passivated Li anodes demonstrate a superb cycling performance up to 2300 h (230 cycles at 1000 mAh g , 200 mA g ). More strikingly, the anode recycled thereafter can be recoupled with a fresh cathode to continuously run for 400 extended hours. Comprehensive time-lapse and ex situ microscopic and spectroscopic investigations are further carried out for elucidating the fundamentals behind the extraordinary air and electrochemical stability.
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http://dx.doi.org/10.1002/advs.202100488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8373161PMC
August 2021

Role of Two Plant Growth-Promoting Bacteria in Remediating Cadmium-Contaminated Soil Combined with (Lab.).

Plants (Basel) 2021 May 2;10(5). Epub 2021 May 2.

College of Bioscience and Biotechnology, College of Resource and Environment, Hunan Agricultural University, Changsha 410128, China.

spp. are energy plants and excellent candidates for phytoremediation approaches of metal(loid)s-contaminated soils, especially when combined with plant growth-promoting bacteria. Forty-one bacterial strains were isolated from the rhizosphere soils and roots tissue of five dominant plants ( Levl., Vaniot Houtt, L., Tenore, and Lab.) colonizing a cadmium (Cd)-contaminated mining area (Huayuan, Hunan, China). We subsequently tested their plant growth-promoting (PGP) traits (e.g., production of indole-3-acetic acid, siderophore, and 1-aminocyclopropane-1-carboxylate deaminase) and Cd tolerance. Among bacteria, two strains, TS8 and MR2, presented higher Cd tolerance and showed the best results regarding in vitro growth-promoting traits. In the subsequent pot experiments using soil spiked with 10 mg Cd·kg, we investigated the effects of TS8 and MR2 strains on soil Cd phytoremediation when combined with (Lab.). After sixty days of planting (Lab.), we found that TS8 increased plant height by 39.9%, dry weight of leaves by 99.1%, and the total Cd in the rhizosphere soil was reduced by 49.2%. Although MR2 had no significant effects on the efficiency of phytoremediation, it significantly enhanced the Cd translocation from the root to the aboveground tissues (translocation factor > 1). The combination of TS8 and (Lab.) may be an effective method to remediate Cd-contaminated soils, while the inoculation of MR2 may be used to enhance the phytoextraction potential of .
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http://dx.doi.org/10.3390/plants10050912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8147505PMC
May 2021

Microwave absorption enhancement of 2-dimensional CoZn/[email protected]@PPy composites derived from metal-organic framework.

J Colloid Interface Sci 2021 Oct 30;600:209-218. Epub 2021 Apr 30.

School of Civil Engineering, Qingdao University of Technology, Qingdao 266033, People's Republic of China.

Metal-organic framework (MOF) materials have caused widespread concerns in the field of microwave absorption, due to the unique microstructure and electronic state. Herein, the CoZn/[email protected]@polypyrrole (PPy) composites were prepared through MOF self-template method. The MoS sheets and PPy shell incorporated for optimizing impedance matching of two-dimensional (2D) CoZn/C composites. The introduction of MoS sheets and PPy shell endowed the composites with enhanced microwave absorption. The as-prepared CoZn/[email protected]@PPy composites showed a minimum reflection loss (RL) of -49.18 dB with the thickness of 1.5 mm. In addition, the effective absorption bandwidth (EAB, RL values exceeding -10 dB) covered 4.56 GHz, which showed greater performances than CoZn/C composites under a lower thickness (<2 mm). This work not only provides a facile route for fabricating MOF-derived carbon-based composites as microwave absorbers, but also broadens the application of MOF materials.
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http://dx.doi.org/10.1016/j.jcis.2021.04.137DOI Listing
October 2021

Fabrication of one-dimensional [email protected]@MoS/FeS composites as electromagnetic wave absorber.

J Colloid Interface Sci 2021 Oct 4;600:90-98. Epub 2021 May 4.

School of Civil Engineering, Qingdao University of Technology, Qingdao 266033, People's Republic of China.

In this work, one-dimensional (1D) [email protected]@MoS/FeS composites were synthesized by hydrothermal method, magnetic-field-induced distillation-precipitation polymerization and high-temperature carbonization. The structure, morphology, composition, magnetic performance and electromagnetic (EM) wave absorbing properties of the composites were systematically studied. The composites show strong microwave absorption (MA) capacity with a minimum reflection loss (RL) value of -52.5 dB at 13.2 GHz, and have an effective absorption frequency range of 10.10-15.08 GHz with a bandwidth of 4.98 GHz when the thickness is 2.23 mm. It is expected that as-synthesized 1D [email protected]@MoS/FeS composites can be a promising EM wave absorption material.
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http://dx.doi.org/10.1016/j.jcis.2021.04.142DOI Listing
October 2021

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq.

Signal Transduct Target Ther 2021 05 17;6(1):195. Epub 2021 May 17.

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.

B cell response plays a critical role against SARS-CoV-2 infection. However, little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection. Here, we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients, and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses. Via linking BCR to antigen specificity through sequencing (LIBRA-seq), we identified a distinct activated memory B cell subgroup (CD11c CD95) had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells. Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection. The public antibody clonotypes were shared by distinct convalescent individuals. Moreover, several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain (RBD) or nucleoprotein (NP) via ELISA assay. Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro. Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level.
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http://dx.doi.org/10.1038/s41392-021-00610-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127497PMC
May 2021
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