Publications by authors named "Yong Lu"

462 Publications

The high prevalence of abnormal MRI findings in non-neuropsychiatric patients with persistently positive antiphospholipid antibodies.

Rheumatology (Oxford) 2021 Sep 24. Epub 2021 Sep 24.

Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: Thrombosis occurring in the central nerve system is common in antiphospholipid syndrome (APS) patients, leading to neuropsychiatric symptoms. We investigated the prevalence of silent brain abnormalities on magnetic resonance imaging (MRI) in primary antiphospholipid syndrome (PAPS) patients and antiphospholipid antibodies (aPL) carriers and assessed the association between the vascular risk factors, aPL profile, clinical manifestations, and MRI abnormalities.

Methods: We consecutively included 44 PAPS patients, 24 aPL carriers and 23 healthy controls with comparable age and gender in a single-center, observational cross-sectional study. None of the patients had a history of stroke, TIA, migraine, dementia, epilepsy and bipolar disorders. On cerebral MRI, we assessed the imaging features and location of abnormality. Multivariate analysis was performed to identify the risk factors contributing to the MRI abnormalities.

Results: 38 (55.88%) patients persisted abnormal MRI findings, while only one healthy control showed some abnormalities in the MR findings. Lacunes were the most frequent MRI abnormality in aPL (+) group (31/68, 45.59%), which were followed by white matter hyperintensities (20/68, 29.41%). In all study population, age (OR = 1.086, p= 0.016) and LA positivity (OR = 5.191, p= 0.002) were the independent associated factors with the brain MRI abnormalities. When analyzed only in the aPL (+) group, age (OR = 1.116, p= 0.007), female gender (OR = 7.519, p= 0.025) and thrombocytopenia (OR = 8.336, p= 0.047) were the significant independent risk factors with abnormal MRI.

Conclusions: PAPS patients and aPL carriers showed a high prevalence of brain MRI abnormalities, indicating an increased cerebrovascular risk, which emphasized attention to silent cerebral lesions in persistently aPL positive patients.
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http://dx.doi.org/10.1093/rheumatology/keab649DOI Listing
September 2021

Wearable, Washable, and Highly Sensitive Piezoresistive Pressure Sensor Based on a 3D Sponge Network for Real-Time Monitoring Human Body Activities.

ACS Appl Mater Interfaces 2021 Sep 23. Epub 2021 Sep 23.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

Wearable pressure sensors are highly desirable for monitoring human health and realizing a nice human-machine interaction. Herein, a chitosan/MXene/polyurethane-sponge/polyvinyl alcohol (CS/MXene/PU sponge/PVA)-based 3D pressure sensor is developed to simultaneously achieve wearability, washability, and high sensitivity in a wide region. In the force-sensitive layer of the sensor, MXene and CS are fully attached to the PU sponge to ensure that the composite sponge has remarkable conductivity and washability. Benefiting from the highly resistive PVA-nanowire spacer, the initial current of the sensor is reduced significantly so that the sensor exhibits extremely high sensitivity (84.9 kPa for the less than 5 kPa region and 140.6 kPa for the 5-22 kPa region). Moreover, the sensor has an excellent fast response time of 200 ms and a short recovery time of 30 ms, as well as non-attenuating durability over 5000 cycles. With the high sensitivity in a wide range, the sensor is capable of detecting multiple human and animal activities in real time, ranging from the large pressure of joint activities to a subtle pressure of pulse. Furthermore, the sensor also demonstrates the potential application in measuring pressure distribution. Overall, such a multifunctional pressure sensor can supply a new platform for the design and development of wearable health-monitoring equipment and an efficient human-machine interface.
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http://dx.doi.org/10.1021/acsami.1c09975DOI Listing
September 2021

Visible-light-assisted peroxymonosulfate activation by metal-free bifunctional oxygen-doped graphitic carbon nitride for enhanced degradation of imidacloprid: Role of non-photochemical and photocatalytic activation pathway.

J Hazard Mater 2021 Aug 29;423(Pt B):127048. Epub 2021 Aug 29.

Department of Environmental Science and Engineering, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address:

Bifunctional oxygen-doped graphitic carbon nitride (OCN) was fabricated to activate peroxymonosulfate (PMS) for degrading imidacloprid (IMD). The modulated electronic structure of OCN promoted the adsorption, electron transfer, and formation of the redox site of PMS. The light absorption capacity, and the separation and migration speed of photogenerated carriers of OCN were increased. Consequently, 94.5% of IMD (3.0 mg/L) was removed by OCN-10/PMS process in 2.0 h. Compared with g-CN/PMS (0.048 h), the IMD degradation rate constant of OCN-10/Vis/PMS system (1.501 h) was increased by 30.3 times. The PMS oxidation on electron-deficient C atoms and holes, the PMS reduction around electron-rich O atoms and photogenerated electrons, and the multiple reactions of superoxide radical were the sources of the main active species singlet oxygen. Moreover, even under different pH conditions, coexisting anions, humic acid, and other neonicotinoid pesticides, the OCN-10/Vis/PMS system still showed acceptable applicability. Finally, mass spectrometry identified that hydroxylation and N-dealkylation of amines were the primary degradation pathways of IMD. This paper demonstrates an environmental-friendly combined activation strategy of PMS that can be operated day and night with low energy consumption, aiming to pave the way for developing metal-free photocatalysts for high-efficient environmental purification based on advanced oxidation coupling technology.
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http://dx.doi.org/10.1016/j.jhazmat.2021.127048DOI Listing
August 2021

Clinical analysis of systemic administration combined with microwave ablation in the treatment of lung cancer.

Authors:
Kan Feng Yong Lu

Asian J Surg 2021 Sep 9. Epub 2021 Sep 9.

Department of Thoracic Surgery, The First Hospital of Fuyang Hangzhou, Hangzhou, Zhejiang Province, 3114000, China.

Objective: To explore the therapeutic effect of systemic administration combined with microwave ablation (MWA) under computed tomography (CT) and fiberoptic bronchoscope for treating lung cancer.

Methods: Sixty-six patients with advanced lung cancer admitted to our hospital from February 2019 to February 2020 were collected and divided into control group and experimental group with 33 patients in each group. The control group was treated with systemic administration, and the experimental group was treated with systemic administration combined with MWA under CT and fiberoptic bronchoscope. Overall response rate (ORR), adverse events (AEs) during treatment, and survival analysis were used to evaluate the curative effect of lung cancer treatment in each group.

Results: MWA under CT and fiberoptic bronchoscope could safely remove the cancerous tissues by point burning without destroying the adjacent normal tissues with high success rate. The ORR of the control group was 24.4%, and that of the experimental group was 63.6%, which was better than the control group. The AEs occurred during treatment in each group were of level 1 or level 2, and no serious life-threatening AEs occurred. Progression-free survival (PFS) time and overall survival (OS) time in the experimental group were both longer than those in the control group. Patients treated with MWA had a lower risk of disease progression and death than those treated with systemic administration alone.

Conclusion: The treatment of lung cancer using systemic administration combined with MWA under CT and fiberoptic bronchoscope is more effective than using systemic administration alone, which can be promoted in clinical treatment.
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http://dx.doi.org/10.1016/j.asjsur.2021.08.013DOI Listing
September 2021

Aberrant FBXW7-mediated ubiquitination and degradation of ZMYND8 enhances tumor progression and stemness in bladder cancer.

Exp Cell Res 2021 Sep 3;407(2):112807. Epub 2021 Sep 3.

Department of Urology, The First Affiliated Hospital of Soochow University, China. Electronic address:

ZMYND8, an epigenetic regulator, was identified as a common oncogene across various tumors. However, little was reported about the association between ZMYND8 and bladder cancer. Besides, aberrant mechanisms that contribute to abnormal ZMYND8 expressions still remain unclear. In the current study, we first found that ZMYND8 protein levels were significantly elevated in Bca samples versus normal tissues, but not the mRNA levels. We then utilized the Cell Counting Kit-8 (CCK-8) assay, clone formation assay and transwell analysis to confirm that ZMYND8 could remarkably promote the tumor progression in vitro, including growth capacity and migration. Bioinformatic predictive analysis revealed that E3 ubiquitin ligase FBXW7 interacts directly with ZMYND8 and degrades ZMYND8 in a polyubiquitination manner. Low FBXW7 was a hazard factor for promoting and depending on accumulated ZMYND8 proteins to promote Bca progression. Gene set enrichment analysis (GSEA) further indicated that ZMYND8 was notably associated with stemness process, which was well functionally validated. Lastly, ZMYND8 deficiency was observed to inhibit tumor growth of Bca in vivo, revealing a promising translational significance in Bca treatment. In conclusion, our study for the first time provided evidence for a novel mechanism of FBXW7/ZMYND8 axis in Bca, providing therapeutic vulnerability for individualized cancer treatment.
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http://dx.doi.org/10.1016/j.yexcr.2021.112807DOI Listing
September 2021

Demographic Characteristics and Lifestyle Habits of Chinese Plasma Donors: A Multicenter Study.

Med Sci Monit 2021 Aug 27;27:e931471. Epub 2021 Aug 27.

Department of Plasma Proteins, Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China (mainland).

BACKGROUND The demand for plasma and plasma products has increased in China, which has a short supply. Compared with whole blood donors, plasma donors and their donation behavior have received less attention. This study aimed to investigate the demographic characteristics and lifestyle habits of Chinese plasma donors. MATERIAL AND METHODS During 2018-2019, information on plasma donors was collected from blood product companies using a 25-item questionnaire, including sex, age, height, weight, blood group, donation frequency, occupation, smoking and drinking, and sleeping and dietary habits. RESULTS Among 15 497 plasma donors, 70.5% were women and 78.5% were aged 46-55 years. Among 4847 plasma donors, the average height of men was 169.5±6.2 cm and the average height of women was 157.0±4.6 cm. In addition, the average weight of men was 67.0±10.4 kg and the average weight of women was 60.0±8.3 kg. The prevalence of obesity (body mass index ≥30.0 kg/m²) of all donors was 14.8%; 14.7% of men were obese, and 15% of women were obese. Among all plasma donors, 88.8% were farmers and 60% were frequent donors with a donation history of at least 5 years. Among all donors, 84.0% did not smoke, 67.3% did not drink, and 95.1% reported good sleep quality. All respondents reported healthy dietary habits. CONCLUSIONS Healthy lifestyle habits considerably affect the health of plasma donors and the quality of source plasma. Chinese plasma donors in this study demonstrated imbalances in terms of characteristics, which became more marked with age.
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http://dx.doi.org/10.12659/MSM.931471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406814PMC
August 2021

Insights into the Ionic Conduction Mechanism of Quasi-Solid Polymer Electrolytes through Multispectral Characterization.

Angew Chem Int Ed Engl 2021 Aug 22. Epub 2021 Aug 22.

Frontiers Science Center for New Organic Matter, Renewable Energy Conversion and Storage Center (RECAST), Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin, 300071, China.

Quasi-solid polymer electrolytes (QPE) composed of Li salts, polymer matrix, and solvent, are beneficial for improving the security and energy density of batteries. However, the ionic conduction mechanism, existential form of solvent molecules, and interactions between different components of QPE remain unclear. Here we develop a multispectral characterization strategy combined with first-principles calculations to unravel aforesaid mysteries. The results indicate that the existential state of solvent in QPE is quite different from that in liquid electrolyte. The Li cations in gel polymer electrolyte are fully solvated by partial solvent molecules to form a local high concentration of Li , while the other solvent molecules are fastened by polymer matrix in QPE. As a result, the solvation structure and conduction mechanism of Li are similar to those in high-concentrated liquid electrolyte. This work provides a new insight into the ionic conduction mechanism of QPE and will promote its application for safe and high-energy batteries.
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http://dx.doi.org/10.1002/anie.202107648DOI Listing
August 2021

A comparative study of the RuiBreath and NIOX VERO analyzers for detecting fractional exhaled nitric oxide.

J Thorac Dis 2021 Jul;13(7):4418-4426

Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.

Background: Fractional exhaled nitric oxide (FeNO) measurement is a reliable, noninvasive marker of airway inflammation. Portable FeNO analyzers facilitate the assessment of airway inflammation in primary care. Differences between analyzers from different manufacturers are not comparable. Here, we aimed to compare the FeNO values obtained by a new portable device (RuiBreath, Guangzhou Ruipu Medical Technology Co., Ltd, Guangzhou, China) to those obtained by the widely used NIOX VERO portable analyzer (Aerocrine AB, Solna, Sweden) in patients with asthma.

Methods: This prospective validation study enrolled patients (≥14 years old) with asthma over a 2-month period (July and August 2019) at the Beijing Chao-Yang Hospital. At least one valid FeNO measurement was obtained using each analyzer for all the participants.

Results: There were 197 participants in this study. The FeNONIOX and FeNORuiBreath values significantly differed (P=0.016). After log-transformation, a difference was found only when the FeNONIOX was <25 ppb (P<0.001). The FeNONIOX and FeNORuiBreath values had a significant correlation (r=0.938, P<0.001), which was confirmed by the Altman-Bland plot. Using a receiver-operating characteristic curve analysis, when using 49 ppb as the cut-off point for the two devices in identifying patients with symptomatic asthma symptoms, the sensitivity and specificity were 0.42 and 0.88, respectively, by NIOX, and 0.40 and 0.89, respectively, by RuiBreath.

Conclusions: This is the first report of FeNO values obtained by the new portable RuiBreath FeNO analyzer. The FeNORuiBreath values are reliable and directly comparable with the FeNONIOX values.
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http://dx.doi.org/10.21037/jtd-21-25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339745PMC
July 2021

PKD1 alleviates oxidative stress-inhibited osteogenesis of rat bone marrow-derived mesenchymal stem cells through TAZ activation.

J Cell Biochem 2021 Aug 18. Epub 2021 Aug 18.

Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Oxidative stress is known to inhibit osteogenesis and PKD1 is implicated in bone remodeling and skeletogenesis. In the present study, we explored the role of PKD1 in osteogenesis under oxidative stress. H O was used to induce oxidative stress in rat bone marrow (BM)-mesenchymal stem cells (MSCs) during osteoblast differentiation. Alkaline phosphatase (ALP) activity, calcium deposits, and the RUNX2 marker were assayed to determine osteogenic differentiation. The correlation of PKD1, Sirt1, c-MYC, and TAZ was further confirmed by chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assay. We found that H O induced the downregulation of PKD1 expression and the upregulation of c-MYC, and Sirt1 was accompanied by decreasing cell viability in BM-MSCs. During osteogenic differentiation, the expression of PKD1 was upregulated significantly whereas Sirt1 tended to be upregulated mildly under normal conditions. Both PKD1 and Sirt1 were upregulated upon oxidative stress. The positive correlation of PKD1 expression with osteogenic differentiation under normal conditions might be hindered by oxidative stress and PKD1 could interact with TAZ under oxidative stress to regulate osteogenic differentiation. Our results suggest that PKD1 may alleviate oxidative stress-inhibited osteogenesis of rat BM-MSCs through TAZ activation.
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http://dx.doi.org/10.1002/jcb.30124DOI Listing
August 2021

Structure-Performance Relationships of Covalent Organic Framework Electrode Materials in Metal-Ion Batteries.

J Phys Chem Lett 2021 Aug 18;12(33):8061-8071. Epub 2021 Aug 18.

Frontiers Science Center for New Organic Matter, Renewable Energy Conversion and Storage Center (RECAST), Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), College of Chemistry, Nankai University, Tianjin 300071, China.

Covalent organic frameworks (COFs) have shown great potential as high-performance electrode materials for metal-ion batteries in view of their relatively high capacity, flexibly designable structure, ordered porous structure, and limited solubility in electrolyte. To develop more attractive COF electrode materials, it is necessary to understand their structure-performance relationships. This Perspective focuses on discussing the relationships between structure (molecular structure, micro structure, and electrode structure) and performance (voltage, capacity, cycling stability, and rate performance) of COF electrode materials in metal-ion batteries. Among the reported COF electrode materials, those with all linkages being redox active based on C═O and C═N groups would be the most promising cathode materials because of their high capacity (∼500 mAh g), moderate working voltage (∼2 V vs Li/Li), and good cycling stability. To accelerate practical application of COF electrode materials in metal-ion batteries, future work should pay more attention to function-oriented molecular structure design via theoretical simulations, as well as full-cell fabrication and evaluation. This Perspective will stimulate high-quality research that might lead to future commercialization.
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http://dx.doi.org/10.1021/acs.jpclett.1c02004DOI Listing
August 2021

Designing Anion-Type Water-Free Zn Solvation Structure for Robust Zn Metal Anode.

Angew Chem Int Ed Engl 2021 Aug 11. Epub 2021 Aug 11.

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.

Rechargeable aqueous Zn batteries are potential for large-scale electrochemical energy storage due to their low cost and high security. However, Zn metal anode suffers from the dendritic growth and interfacial hydrogen evolution reaction (HER), resulting in the deterioration of electrode/battery performance. Here we propose that both dendrites and HER are related to the water participated Zn solvation structure-Zn(H O) and thus can be resolved by transforming Zn(H O) to an anion-type water-free solvation structure-ZnCl , which is achieved in traditional ZnSO aqueous electrolyte after adding chloride salt with a bulky cation (1-ethyl-3-methylimidazolium chloride). The elimination of cation-water interaction suppresses HER, while the electrostatic repulsion between Zn tips and the anion solvation structure inhibits dendrite formation. As a result, the electrolyte shows uniform Zn deposition with an average Zn plating/stripping Coulombic efficiency of ≈99.9 %, enabling a capacity retention of 78.8 % after 300 cycles in anode-free Zn batteries with pre-zincificated polyaniline as the cathode. This work provides a novel electrolyte design strategy to prevent HER and realize long-lifespan metal anode.
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http://dx.doi.org/10.1002/anie.202109682DOI Listing
August 2021

Oxygen-deficient metal oxides supported nano-intermetallic InNiC toward efficient CO hydrogenation to methanol.

Sci Adv 2021 Aug 4;7(32). Epub 2021 Aug 4.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

Direct CO hydrogenation to methanol using renewable energy-generated hydrogen is attracting intensive attention, but qualifying catalysts represents a grand challenge. Pure-/multi-metallic systems used for this task usually have low catalytic activity. Here, we tailored a highly active and selective InNiC/ZrO catalyst by tuning the performance-relevant electronic metal-support interaction (EMSI), which is tightly linked with the ZrO type-dependent oxygen deficiency. Highly oxygen-deficient monoclinic-ZrO support imparts high electron density to InNiC because of the considerably enhanced EMSI, thereby enabling InNiC/monoclinic-ZrO with an intrinsic activity three or two times as high as that of InNiC/amorphous-ZrO or InNiC/tetragonal-ZrO The EMSI-governed catalysis observed in the InNiC/ZrO system is extendable to other oxygen-deficient metal oxides, in particular InNiC/FeO, achieving 25.7% CO conversion with 90.2% methanol selectivity at 325°C, 6.0 MPa, 36,000 ml g hour, and H/CO = 10:1. This affordable catalyst is stable for at least 500 hours and is also highly resistant to sulfur poisoning.
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http://dx.doi.org/10.1126/sciadv.abi6012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336954PMC
August 2021

The differentiation of new human CD303 Plasmacytoid dendritic cell subpopulations expressing CD205 and/or CD103 regulated by Non-Small-Cell lung cancer cells.

Int Immunopharmacol 2021 Oct 20;99:107983. Epub 2021 Jul 20.

Department of Experimental and Clinical Immunology, CAS Lamvac Biotech Co., Ltd. Huangpu, Guangzhou, Guangdong, PR China. Electronic address:

CD303 plasmacytoid dendritic cells (pDCs) play an important role in the induction of immune tolerance and antitumor immunity. Here, we focused on the effect of NSCLC cells on the development of CD303 pDC subsets expressing CD205 and/or CD103. The NSCLC cell line H1299 and primary NSCLC cells were incubated with DCs. The protein expression of costimulatory molecules on CD303 pDCs, the production of pro-inflammatory and anti-inflammatory cytokines by CD303 pDCs and the development of CD303 pDC subsets were detected by using flow cytometry. Coculture with NSCLC cells modulates the protein expression of CD86 and HLA-DR on CD303 pDCs. Moreover, NSCLC cells suppressed the production of IL-12 and IL-23 but facilitated the secretion of IL-27 and TGF-β by CD303 pDCs. There were new CD303 pDC subsets expressing CD205 and/or CD103 in healthy donors and NSCLC patients: CD303CD205CD103, CD303CD205CD103, CD303CD205CD103 and CD303CD205CD103 pDCs. NSCLC cells modulated the differentiation of CD303 pDC subpopulations by regulating the protein expression of CD205 and/or CD103 on CD303 pDCs. NSCLC cells may regulate the immune functions of CD303 pDCs by modulating the expression of costimulatory molecules on DCs and the production of pro-inflammatory/anti-inflammatory cytokines by DCs. NSCLC cells also regulate the development of CD303 pDC subsets expressing CD205 and/or CD103. These outcomes may reveal a new cellular mechanism leading to the NSCLC-induced immune-suppressive microenvironment.
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http://dx.doi.org/10.1016/j.intimp.2021.107983DOI Listing
October 2021

Reference values of respiratory impedance with impulse oscillometry in healthy Chinese adults.

J Thorac Dis 2021 Jun;13(6):3680-3691

National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Background: Impulse oscillometry (IO) is a non-invasive pulmonary function test for measuring respiratory impedance. Available reference equations of IO indices for adults are limited. The aim of this study was to develop reference equations of IO indices for Chinese adults.

Methods: In a multicentral, cross-sessional study of IO in Chinese adults, IO data from healthy subjects were collected from 19 general hospitals across China between 2016 and 2018. Oscillometry measurements were conducted in accordance with recommendations of the European Respiratory Society (ERS). Multiple linear regression was performed to develop sex-specific reference equations of IO indices.

Results: IO measurements were performed in 1,318 subjects, of which 567 subjects were defined as healthy individuals with acceptable IO data and were included in the final analysis. Reference equations and limits of normal [lower limit of normal (LLN)/upper limit of normal (ULN)] of IO indices were developed separately for males and females. Height but not age was shown to be the most influential contributor to IO indices. The reference equations currently used in lung function laboratories predicted higher 5 and 5. Normal ranges of 5 and 5 recommended by the equipment manufacturer were clearly different from the ULN/LLN derived from the reference equations.

Conclusions: Reference equations of IO indices for Chinese adults from a wide region were provided in this study. It is necessary to update new IO reference equations and adopt ULN/LLN as normal ranges of IO indices.

Trial Registration: This study was registered at www.clinicaltrials.gov as part of a larger study NCT03467880.
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http://dx.doi.org/10.21037/jtd-20-3376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264702PMC
June 2021

Combined effects of hydralazine and nitrate on serum biochemistry and left ventricular remodeling in chronic heart failure patients.

Pak J Pharm Sci 2021 Jan;34(1(Special)):381-386

Heart Rehabilitation Center, Department of Cardiology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.

To investigate the effects of hydralazine combined with nitrate on serum levels of Adropin and brain natriuretic peptide (BNP), left ventricular remodeling and prognosis in patients with chronic heart failure (CHF). 126 CHF patients were divided into control group (n=13, sodium nitroprusside) and combined treatment group (n=63, sodium nitroprusside ± hydralazine). Serum Adropin and BNP levels and left ventricular mass index (LVMI) of patients before treatment and 10 days after treatment were recorded, so did patient's end-point events. It was found that compared with those before treatment, the serum levels of Adropin, BNP, and LVMI in combined group and control group after 10 days of treatment were lower (P<0.05). The end-point event rate in the combined group was 19.05% (12/63). The serum levels of Adropin, BNP, and LVMI in the combined group with end-point events were higher than those of patients without end-point events (P<0.05). Spearman correlation analysis showed that serum levels of Adropin and BNP were positively correlated with LVMI and the end-point events rate (P<0.05). To sum up, hydralazine combined with sodium nitroprusside treatment can effectively reduce serum Adropin and BNP levels, and the risk of left ventricular remodeling and poor prognosis in patients with CHF.
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January 2021

Cooperative Catalysis of Ru(III)-Porphyrin in CO -Involved Synthesis of Oxazolidinones.

Chem Asian J 2021 Sep 26;16(17):2504-2510. Epub 2021 Jul 26.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P. R. China.

CO -transformations into high value-added products have become a fascinating area in green chemistry. Herein, a Ru(III)-porphyrin catalyst (RuCl  ⋅ 3H O-H TPP) was found highly efficient in the three-component reaction of CO , aliphatic amines and dichloroethane (or its derivative) for synthesis of oxazolidinones in the yields of 71∼91%. It was indicated by means of the control experiments and UV-vis spectra that CO was stoichiometrically activated by the involved aliphatic amine substrates to form a stable carbamate salt while 1,2-dichloroethane (or its derivative) was independently activated by the involved Ru(III)-porphyrin catalyst. The combination of CO -activation by aliphatic amines with 1,2-dichloroethane activation by Ru(III)-porphyrin catalyst cooperatively contributed to this successful transformation.
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http://dx.doi.org/10.1002/asia.202100533DOI Listing
September 2021

Propagating Wigner-Negative States Generated from the Steady-State Emission of a Superconducting Qubit.

Phys Rev Lett 2021 Jun;126(25):253602

Department of Microtechnology and Nanoscience MC2, Chalmers University of Technology, SE-412 96 Göteborg, Sweden.

We experimentally demonstrate the steady-state generation of propagating Wigner-negative states from a continuously driven superconducting qubit. We reconstruct the Wigner function of the radiation emitted into propagating modes defined by their temporal envelopes, using digital filtering. For an optimized temporal filter, we observe a large Wigner logarithmic negativity, in excess of 0.08, in agreement with theory. The fidelity between the theoretical predictions and the states generated experimentally is up to 99%, reaching state-of-the-art realizations in the microwave frequency domain. Our results provide a new way to generate and control nonclassical states, and may enable promising applications such as quantum networks and quantum computation based on waveguide quantum electrodynamics.
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http://dx.doi.org/10.1103/PhysRevLett.126.253602DOI Listing
June 2021

Association of fine particulate matter air pollution and its constituents with lung function: The China Pulmonary Health study.

Environ Int 2021 11 26;156:106707. Epub 2021 Jun 26.

Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China; National Center of Gerontology, Beijing, China.

The associations of long-term exposure to various constituents of fine particulate matter (≤2.5 μm in aerodynamic diameter, PM) air pollution with lung function were not clearly elucidated in developing countries. The aim was to evaluate the associations of long-term exposure to main constituents of PM with lung function in China. This is a nationwide, cross-sectional analysis among 50,991 study participants from the China Pulmonary Health study. Multivariable linear regression models were used to obtain differences of forced expiratory volume in 1 s (FEV), forced vital capacity (FVC), FEV/FVC, peak expiratory flow (PEF), and forced expiratory flow at 25-75% of exhaled FVC (FEF) associated with an interquartile range (IQR) change of PM or its constituents. Residential annual PM levels varied from 26 μg/m to 92 μg/m (average: 53 μg/m). An IQR increase of PM concentrations was associated with lower FEV (19.82 mL, 95% CI: 11.30-28.33), FVC (17.45 mL, 95% CI: 7.16-27.74), PEF (86.64 mL/s, 95% CI: 59.77-113.52), and FEF (31.93 mL/s, 95% CI: 16.64-47.22). Black carbon, organic matter, ammonium, sulfate, and nitrate were negatively associated with most lung function indicators, with organic matter and nitrate showing consistently larger magnitude of associations than PM mass. This large-scale study provides first-hand epidemiological evidence that long-term exposure to ambient PM and some constituents, especially organic matter and nitrate, were associated with lower large- and small- airway function.
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http://dx.doi.org/10.1016/j.envint.2021.106707DOI Listing
November 2021

[Clinical observation of double mini locking plate in the treatment of olecranon fracture].

Zhongguo Gu Shang 2021 Jun;34(6):554-8

The First Department of Traumatic Othopaedics, Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China.

Objective: To investigate the clinical effect of double mini-locking plates in the treatment of ulna olecranon fractures.

Methods: From March 2017 to May 2020, 19 patients with olecranon fractures were treated with double mini locking plates, including 12 males and 7 females, aged from 20 to 75 years old with an average of (40.50±7.62) years old;10 patients had the injuries on the left side and 9 patients on the right side. All the 19 patients were fresh closed fractures without ulnar coronoid process fracture, elbow dislocation and other injuries. The fracture healing time and complications were recorded, and the clinical efficacy was evaluated by Mayo elbow performance score (MEPS) before operation and 12 months after operation.

Results: All the 19 patientswas followed up, and the duration ranged from 12 to 17 months with an average of (13.51±3.17) months. Postoperative follow-up showed all fractures healed. Fracture healing time ranged from 2 to 6 months, with an average of(3.77±1.24) months. There was no internal fixation fracture, screw loosening, infection, internal fixation irritation, heterotopic ossification, elbow stiffness and other complications occurred. The MEPS score of affected elbow at 12 months after operation was 91.26±3.87, which was significantly different from that before operation 56.18±9.56 (<0.05);according to Mayo Elbow function score standard, 11 cases were excellent, 7 cases were good, and 1 case was fair.

Conclusion: It is a reliable fixation method to treat olecranon fracture with double mini locking plate. The incision lengh is small and the fracture fixation is reliable. Elbow joint function exercise can be performed early after operation. Postoperative internal fixation has less skin irritation and satisfactory elbow joint function recovery.
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http://dx.doi.org/10.12200/j.issn.1003-0034.2021.06.015DOI Listing
June 2021

Peritumoral Microgel Reservoir for Long-Term Light-Controlled Triple-Synergistic Treatment of Osteosarcoma with Single Ultra-Low Dose.

Small 2021 Aug 25;17(31):e2100479. Epub 2021 Jun 25.

Department of Radiology, Shanghai Institute of Traumatology and Orthopaedics, RuiJin Hospital LuWan Branch, Shanghai Jiao Tong University School of Medicine, 149 ChongqingNan Road, Shanghai, 200020, P. R. China.

Local minimally invasive injection of anticancer therapies is a compelling approach to maximize the utilization of drugs and reduce the systemic adverse drug effects. However, the clinical translation is still hampered by many challenges such as short residence time of therapeutic agents and the difficulty in achieving multi-modulation combination therapy. Herein, mesoporous silica-coated gold nanorods ([email protected] ) core-shell nanoparticles are fabricated to facilitate drug loading while rendering them photothermally responsive. Subsequently, [email protected] is anchored into a monodisperse photocrosslinkable gelatin (GelMA) microgel through one-step microfluidic technology. Chemotherapeutic drug doxorubicin (DOX) is loaded into [email protected] and 5,6-dimethylxanthenone-4-acetic acid (DMXAA) is loaded in the microgel layer. The osteosarcoma targeting ligand alendronate is conjugated to [email protected] to improve the tumor targeting. The microgel greatly improves the injectability since they can be dispersed in buffer and the injectability and degradability are adjustable by microfluidics during the fabrication. The drug release can, in turn, be modulated by multi-round light-trigger. Importantly, a single super low drug dose (1 mg kg DOX with 5 mg kg DMXAA) with peritumoral injection generates long-term therapeutic effect and significantly inhibited tumor growth in osteosarcoma bearing mice. Therefore, this [email protected] system can act as a peritumoral reservoir for long-term effective osteosarcoma treatment.
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http://dx.doi.org/10.1002/smll.202100479DOI Listing
August 2021

Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.

Proc Natl Acad Sci U S A 2021 Jun;118(25)

Discovery Chemistry Department, AbbVie Inc., South San Francisco, CA 94080;

Antibody-drug conjugates (ADCs) have emerged as valuable targeted anticancer therapeutics with at least 11 approved therapies and over 80 advancing through clinical trials. Enediyne DNA-damaging payloads represented by the flagship of this family of antitumor agents, -acetyl calicheamicin [Formula: see text], have a proven success track record. However, they pose a significant synthetic challenge in the development and optimization of linker drugs. We have recently reported a streamlined total synthesis of uncialamycin, another representative of the enediyne class of compounds, with compelling synthetic accessibility. Here we report the synthesis and evaluation of uncialamycin ADCs featuring a variety of cleavable and noncleavable linkers. We have discovered that uncialamycin ADCs display a strong bystander killing effect and are highly selective and cytotoxic in vitro and in vivo.
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http://dx.doi.org/10.1073/pnas.2107042118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237573PMC
June 2021

Ni-Foam-Structured Ni-AlO Ensemble as an Efficient Catalyst for Gas-Phase Acetone Hydrogenation to Isopropanol.

ACS Appl Mater Interfaces 2021 Jun 13;13(24):28334-28347. Epub 2021 Jun 13.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

The free-standing Ni-AlO ensemble derived from NiAl-layered double hydroxides (NiAl-LDHs) grown onto a Ni-foam has been developed for the exothermic gas-phase acetone hydrogenation to isopropanol. This approach works effectively and efficiently to achieve a unique combination of high activity/selectivity and enhanced heat/mass transfer stemmed from the Ni-foam. The outstanding catalyst is obtained by direct reduction of the un-calcined NiAl-LDH/Ni-foam, with a high turnover frequency of 0.90 s, being capable of converting 90.8% acetone into isopropanol with almost 100% selectivity under stoichiometric H/acetone molar ratio, atmospheric pressure at 80 °C, and a WHSV of 10 h. The catalyst derivation using the un-calcined NiAl-LDH/Ni-foam enables the Ni nanoparticles to be intertwined with AlO to form a large Ni-AlO interface, without interruption of impurities such as irreducible NiO (in the case of calcined NiAl-LDH/Ni-foam samples), which markedly improves the strong acetone adsorption next to the Ni hydrogenation sites, thereby leading to a dramatic improvement of catalyst activity.
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http://dx.doi.org/10.1021/acsami.1c07084DOI Listing
June 2021

Predicting Treatment Response to Neoadjuvant Chemoradiotherapy in Rectal Mucinous Adenocarcinoma Using an MRI-Based Radiomics Nomogram.

Front Oncol 2021 24;11:671636. Epub 2021 May 24.

Department of Radiology, Changhai Hospital, Shanghai, China.

Objective: To build and validate an MRI-based radiomics nomogram to predict the therapeutic response to neoadjuvant chemoradiotherapy (nCRT) in rectal mucinous adenocarcinoma (RMAC).

Methods: Totally, 92 individuals with pathologically confirmed RMAC administered surgical resection upon nCRT in two different centers were assessed retrospectively (training set, n = 52, validation set, n = 40). Rectal MRI was performed pre-nCRT. Radiomics parameters were obtained from high-resolution T2-weighted images and selected to construct a radiomics signature. Then, radiomics nomogram construction integrated patient variables and the radiomics signature. The resulting radiomics nomogram was utilized to assess the tumor regression grade (TRG). Diagnostic performance was determined by generating receiver operating characteristic (ROC) curves and decision curve analysis (DCA).

Results: Six optimal features related to TRG were obtained to construct a radiomics signature. The nomogram combining the radiomics signature with age and mucin deposit outperformed the radiomics signature alone in the training (AUC, 0.950 0.843, < 0.05) and validation (AUC, 0.868 0.719, < 0.05) cohorts. DCA demonstrated a clinical utility for the radiomics nomogram model.

Conclusions: The established quantitative MRI-based radiomics nomogram is effective in predicting treatment response to neoadjuvant therapy in patients with RMAC.
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http://dx.doi.org/10.3389/fonc.2021.671636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8181148PMC
May 2021

A Reverse Approach to the Total Synthesis of Halichondrin B.

J Am Chem Soc 2021 Jun 9;143(24):9267-9276. Epub 2021 Jun 9.

Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, Texas 77005, United States.

A new strategy is described for the total synthesis of halichondrin B featuring reversal of the sequential construction of a number of its cyclic ethers from the classical approach by instead forming C-O bonds first followed by C-C bond formation. Employing the Nicholas reaction to generate linear ethers as precursors for the total synthesis of halichondrin B and other members of the halichondrin and eribulin families of compounds, this novel approach provides new opportunities for the development of improved syntheses of these complex and valuable compounds. In this Article, we report the syntheses of defined fragments , , , and . Fragments and were then coupled and elaborated to advanced intermediate , which was joined with fragment to afford, after appropriate elaboration and macrolactonization, the more advanced polycyclic intermediate . Elaboration of the latter and coupling with fragment followed by further functionalization completed the total synthesis of halichondrin B through a short and convergent pathway.
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http://dx.doi.org/10.1021/jacs.1c05270DOI Listing
June 2021

Regulating Electrocatalytic Oxygen Reduction Activity of a Metal Coordination Polymer via d-π Conjugation.

Angew Chem Int Ed Engl 2021 Jul 26;60(31):16937-16941. Epub 2021 Jun 26.

Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Renewable Energy Conversion and Storage Center (RECAST), College of Chemistry, Nankai University, Tianjin, 300071, China.

Non-noble transition metal complexes have attracted growing interest as efficient electrocatalysts for oxygen reduction reaction (ORR) while their activities still lack rational and effective regulation. Herein, we propose a d-π conjugation strategy for rough and fine tuning of ORR activity of TM-BTA (TM=Mn/Fe/Co/Ni/Cu, BTA=1,2,4,5-benzenetetramine) coordination polymers. By first-principle calculations, we elucidate that the strong d-π conjugation elevates the d /d orbitals of TM centers to enhance intermediate adsorption and strengthens the electronic modulation effect from substitute groups on ligands. Based on this strategy, Co-TABQ (tetramino benzoquinone) is found to approach the top of ORR activity volcano. The synthesized Co-TABQ with atomically distributed Co on carbon nanotubes exhibits a half-wave potential of 0.85 V and a specific current of 127 mA mg at 0.8 V, outperforming the benchmark Pt/C. The high activity, low peroxide yield, and considerable durability of Co-BTA and Co-TABQ promise their application in oxygen electrocatalysis. This study provides mechanistic insight into the rational design of transition metal complex catalysts.
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http://dx.doi.org/10.1002/anie.202104494DOI Listing
July 2021

Change in Susceptibility Values in Knee Cartilage After Marathon Running Measured Using Quantitative Susceptibility Mapping.

J Magn Reson Imaging 2021 May 24. Epub 2021 May 24.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Background: Quantitative susceptibility mapping (QSM) has been used to study the magnetic susceptibility properties of collagen fibers in articular cartilage; however, it is unclear whether QSM is sensitive to changes due to degradation caused by long-distance running. It is clinically important to understand the link between long-distance running and microstructural changes in knee cartilage.

Purpose: To investigate the ability of QSM to assess microstructural changes within cartilage after repetitive loading.

Study Type: Prospective.

Population: Thirteen recreational, male long-distance runners.

Field Strength/sequence: Three-dimensional gradient recalled echo acquired at 3 T.

Assessment: Magnetic resonance imaging (MRI) and 3D kinematics (translations and rotations during treadmill walking and running) of the knee joint were collected before and after marathon running. The compartments for analysis included the patella, trochlea, and subregions of femoral and tibial cartilage. Changes in regional susceptibility and cartilage thickness were calculated after marathon running. A susceptibility profile was obtained by fitting susceptibility as a function of the normalized depth of cartilage from the superficial to deep layers.

Statistical Tests: Paired t-test or Wilcoxon signed-rank test, 95% confidence interval (CI) of the depth-wise susceptibility profile, Pearson correlation or Spearman correlation.

Results: There was a statistically significant increase in susceptibility value in the weight-bearing region of central medial femoral cartilage (cMF-c) after marathon running (pre-marathon: -0.0219 ± 0.0151 ppm, post-marathon: -0.0070 ± 0.0213 ppm, P < 0.05), while the cartilage thickness did not show significant changes in any regions (P-value range: 0.068-0.963). Significant susceptibility elevations occurred in the middle and deep layers of cMF-c (95% CIs did not overlap). A trend toward a positive correlation was found between the changes in susceptibility value in cMF-c and proximal-distal translation of the knee joint during walking (r = 0.55, P = 0.101) and running (r = 0.57, P = 0.089).

Data Conclusion: Localized magnetic susceptibility alterations were observed within knee cartilage in the weight-bearing area after repetitive loading without any morphologic changes.

Level Of Evidence: 2 TECHNICAL EFFICACY: Stage 2.
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http://dx.doi.org/10.1002/jmri.27745DOI Listing
May 2021

Preoperative analysis of upper lip in patients with upper cleft lip/palate before lip repair.

Ann Transl Med 2021 Apr;9(8):698

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.

Background: The postoperative morphological appearances vary widely patients with unilateral cleft lip with or without cleft palate (UCL/P), whether it is complete or incomplete cleft. The main reason of bilateral lip asymmetry after cleft lip surgery lies in the lack of personalized measurement and design before surgery. In this study, we aim to individually investigate areas of the upper lip on cleft and non-cleft sides in patients with unilateral cleft lip with or without cleft palate (UCL/P).

Methods: Ninety-two patients with UCL/P (group 1: <1 year, group 2: 1-2 years) were included in the study. Group 1 included 37 patients with incomplete UCL/P and 29 with complete UCL/P; group 2 included 11 and 15 patients, respectively. The total area of the upper lip on the cleft side (Q8) was divided into Q3, Q4, and Q5 (further divided into a1 and a2), and the upper lip on the non-cleft side (Q7) was divided into Q2 and Q1 (further divided into A1 and A2). Area ratios between the cleft and the non-cleft sides were calculated, and certain parameters were tested for correlations with these ratios.

Results: Values of Q8/Q7 were partially overlapped between patients with complete and incomplete UCL/P. Significant correlations were noted between differences in height of the philtrum column (a-h) and the prolabial area ratio between the cleft and the non-cleft side (Q3/Q2) (P=0.032). Moreover, a significant correlation was noted between a1/A1 and the ratio of the lateral labial area between the cleft and the non-cleft side (Q5/Q1) (P=0.001).

Conclusions: The conventional classification of unilateral cleft lip as incomplete and complete does not completely and accurately reflect individual malformations. Therefore, it is necessary to analyze unilateral cleft lips individually to determine the repair technique and to predict postoperative outcomes.
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http://dx.doi.org/10.21037/atm-21-1424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106071PMC
April 2021

Spontaneous formation of multilayer refractory carbide coatings in a molten salt media.

Proc Natl Acad Sci U S A 2021 May;118(18)

Department of Electrical and Computer Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588-0511;

Refractory materials hold great promise to develop functional multilayer coating for extreme environments and temperature applications but require high temperature and complex synthesis to overcome their strong atomic bonding and form a multilayer structure. Here, a spontaneous reaction producing sophisticated multilayer refractory carbide coatings on carbon fiber (CF) is reported. This approach utilizes a relatively low-temperature (950 °C) molten-salt process for forming refractory carbides. The reaction of titanium (Ti), chromium (Cr), and CF yields a complex, high-quality multilayer carbide coating composed of 1) Cr carbide (CrC), 2) Ti carbide, and 3) CrC layers. The layered sequence arises from a difference in metal dissolutions, reactions, and diffusion rates in the salt media. The multilayer-coated CFs act as a permeable oxidation barrier with no crystalline degradation of the CFs after extreme temperature (1,200 °C) and environment (oxyacetylene flame) exposure. The synthesis of high-quality multilayer refractory coating in a fast, efficient, easy, and clean manner may answer the need for industrial applications that develop cheap and reliable extreme environment protection barriers.
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http://dx.doi.org/10.1073/pnas.2100663118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106292PMC
May 2021

Analysis of transient response of the human foot based on the finite element method.

Technol Health Care 2021 Apr 21. Epub 2021 Apr 21.

College of Mechanical Engineering and Automation, Huaqiao University, Xiamen, Fujian, China.

Background: The foot is an important part of the human body. Its functions are mainly walking and load-bearing. It also keeps the human body stable and absorbs ground vibrations to protect important human organs.

Objective: Many researchers use finite element methods to study the biomechanics of the foot. However, current studies on the finite element of the foot are based on the stress and displacement response analysis of the foot under static or quasi-static conditions, ignoring the movement process of the foot and the impact of vibration. Moreover, the joint application of energy method and finite element analysis in foot biomechanics is rarely reported.

Methods: In this paper, to obtain the foot energy transfer process, the transient response of the foot under neutral position is analyzed based on the energy method.

Results: The results show that: (1) In this model, the energy analysis follows the conservation of energy, which indicates that the transient response analysis has obtained a reasonable response. (2) When the foot touches the ground, the strain energy of the calcaneus, second metatarsal and third metatarsal is relatively large, which is consistent with the main stress concentration area of the plantar. (3) The gravity of the human body is mainly transmitted through the talus to the calcaneus, while the effect of transmittal through the scaphoid to the cuneiform bone and metatarsal is weak.

Conclusion: This study can not only more clearly and intuitively reflect the energy transfer and source of various skeletal foreheads in the foot, but also provide a new research idea for the study of foot biomechanics.
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http://dx.doi.org/10.3233/THC-202673DOI Listing
April 2021

A retrospective study on the effectiveness of Artificial Intelligence-based Clinical Decision Support System (AI-CDSS) to improve the incidence of hospital-related venous thromboembolism (VTE).

Ann Transl Med 2021 Mar;9(6):491

Division of Medical Affairs, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Artificial intelligence technology is widely used in the medical industry. Our retrospective study evaluated the effectiveness of an AI-CDSS in improving the incidence of hospital-related VTE and the impact of anticoagulant drug use.

Methods: This study collected relevant data on adult patients over 18 years of age who are not discharged 24 hours, from January to July 2019 and from January to July 2020, the VTE high-risk department of Ruijin Hospital. Before and after using AI-CDSS, the incidence of hospital-related VTE and using anticoagulants were analyzed.

Results: Between January to July 2019 and January to July 2020, 3,565 and 4,423 adult patients over 18 years old were hospitalized in our hospital and were designed as a control group and intervention group, respectively (7,988 in total). Both groups had similar baseline characteristics. There were 4,716 (59.03%) male patients, the mean age was 60.43±13.09 years, and the mean stay was 7.56±7.76 days. More than half of the patients (4,605, 57.58%) came from the respiratory. VTE events during hospitalization occurred in 41 patients; overall, 5.13/1,000 (41 episodes in 7,988 patients). Compared with the control group, before implementing AI-CDSS, the rate of VTE during hospitalization was reduced from 5.89/1,000 (21 episodes in 3,565 patients) to 4.75/1,000 patients (20 episodes in 4,423 patients) (relative reduction of 19.35%) in the intervention group. The use rate of anticoagulant drugs was increased from 19.97% (712/3,565) in the control group to 22.88% (1,012/4,423) in intervention group [P<0.01, odds ratio (OR): 1.19, 95 percent confidence interval (95% CI) (1.07-1.32)], (relative 14.57% increase). Poisson's regression results showed that department, age ≥75 years [OR: 3.09, 95% Cl (1.45-6.33)], duration of hospitalization [OR: 1.04, 95% CI (1.03-1.05)], heart failure [OR: 5.13, 95% CI (1.74-13.54)] and renal failure [OR: 3.60, 95% CI (0.90-11.34)] were high-risk factors for VTE events.

Conclusions: Implementing AI-CDSS can help clinicians identify hospitalized patients at increased VTE risk, take effective preventive measures, and improve clinicians' compliance with the American College of Chest Physicians (ACCP) guidelines.
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http://dx.doi.org/10.21037/atm-21-1093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8039638PMC
March 2021
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