Publications by authors named "Yong Liu"

3,681 Publications

  • Page 1 of 1

Autologous esophageal mucosa with polyglycolic acid transplantation and temporary stent implantation can prevent stenosis after circumferential endoscopic submucosal dissection.

Ann Transl Med 2021 Apr;9(7):546

Department of Endoscopy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: This research aimed at investigating the safety and efficacy of autologous esophageal mucosa (AEM) with polyglycolic acid (PGA) transplantation and temporary stent implantation (TSI) in preventing esophageal stenosis (ES) after early esophageal cancer (EC) surgery.

Methods: Between April 2019 and October 2020, patients scheduled for circumferential endoscopic submucosal dissection (ESD) were prospectively recruited. After ESD, autologous esophageal mucosal patches (MPs) were constructed on the absorbable PGA felt. Then, the felt was structured onto a covered metal mesh stent (CMMS) and attached to the ulcer surface. The stents were removed 6-8 weeks after the operation. The occurrence of ES and adverse events was observed and analyzed.

Results: Data from 25 patients were analyzed. In total, 14 patients (56%) had no stenosis during an average follow-up of 10.2 months, and 11 patients (44%) suffered strictures at a mean interval of 63.73 days after the ESD procedure. Stent migration occurred in 2 patients. No other complications, including perforations, bleeding, or wound infections, occurred. The median of endoscopic balloon dilatation (EBD) sessions was 2.16 (range, 0-14). There showed a higher post-ESD stricture rate in patients with lesions located in the middle-lower esophagus (P<0.05). More transplanted MPs may reduce the occurrence of ES.

Conclusions: AEM with PGA transplantation and TSI is a safe and effective approach of preventing ES and improving the life quality after circumferential ESD.
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http://dx.doi.org/10.21037/atm-20-6987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8105787PMC
April 2021

Real-time observation of pulsating period-doubled vector solitons in a passively mode-locked fiber laser.

Opt Express 2021 Apr;29(9):14101-14111

Dissipative solitons (DSs) are self-organized localized structures in non-conservative systems, which require a continuous energy exchange with external sources. In addition to parameter-invariant stationary DSs, there exists a variety of dynamical ones manifesting breathing behaviors. Such intriguing phenomena, termed as soliton pulsations, have been widely studied in recent years under the impetus of advances in real-time spectroscopy. Here, we experimentally investigate various pulsating period-doubled solitons (PDSs) in a fiber laser mode-locked by single-wall carbon nanotubes. Both single- and double-periodic PDS pulsations are found in the cavity. Thanks to the emerging dispersive Fourier transform technique, the polarization-resolved transient spectra of these pulsating PDSs are measured. It is shown that their polarization ellipses rotate with a period of two cavity roundtrips. Moreover, the intensity-modulation behaviors of the two orthogonal polarization components in the odd (even) roundtrips are always asynchronous, which confirms additional slower polarization modulations. Especially, we demonstrate that three combined intensity-modulation periods are involved in the double-periodic PDS pulsation process for the first time, to the best of our knowledge. Our results would stimulate further research on the vector features of multiple-period pulsating solitons in mode-locked fiber lasers.
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http://dx.doi.org/10.1364/OE.423712DOI Listing
April 2021

A novel Vancomycin-Functionalized-Magnetic Graphene Composite for Use as a Near-Infrared-Induced Synergistic Chemo-Photothermal Antibacterial.

Macromol Biosci 2021 May 13:e2100082. Epub 2021 May 13.

Laboratory of Nanoscale Biosensing and Bioimaging (NBAB), School of Ophthalmology and Optometry, School of Biomedical Engineering, State Key Laboratory of Ophthalmology, Optometry, and Vision Science, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.

Antibiotic-resistant bacterial strains are a major cause of disease. They continue to remain a challenge in the clinic particularly in the vision system. For example, infectious endophthalmitis is a major blind-causing disease caused by bacteria. A highly efficient synergistic antibacterial treatment that uses a photothermal antibacterial therapeutic with a chemo-antibacterial therapeutic in a multifunctional nanocomposite is reported. It is prepared by immobilizing vancomycin onto the surface of a magnetic chitosan-graphene (VCM-MCG) composite. An antibacterial effect is achieved when VCM-MCG is applied. This effect is enhanced when the nanocomposites are irradiated with a near-infrared laser. Growth of gram-positive methicillin-resistant Staphylococcus aureus and gram-negative Escherichia coli bacteria are suppressed efficiently. Such a composite can help manage the control of pathogenic bacteria growth in the clinic.
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http://dx.doi.org/10.1002/mabi.202100082DOI Listing
May 2021

Prevalence of Inflammatory Bowel Disease Among Medicare Fee-For-Service Beneficiaries - United States, 2001-2018.

MMWR Morb Mortal Wkly Rep 2021 May 14;70(19):698-701. Epub 2021 May 14.

Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion, CDC.

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. The number of affected persons worldwide has increased from 3.7 million in 1990 to 6.8 million in 2017 (1). The disease is more prevalent among non-Hispanic White persons than it is among persons in other racial/ethnic groups (2). As the prevalence increases with age group (2), it is important to understand the disease epidemiology among the older population. CDC analyzed 2018 Medicare data among beneficiaries aged ≥67 years to examine differences by demographic characteristics for both diseases and to assess trends of prevalence from 2001 through 2018 both overall and by race and ethnicity. In 2018, 0.40% and 0.64% of 25.1 million Medicare fee-for-service beneficiaries aged ≥67 years had received a diagnosis of either Crohn's disease or ulcerative colitis. Prevalence varied by age, sex, race and ethnicity, urban-rural residency, and state. During 2001-2018, the age-adjusted prevalence of both diseases increased (Crohn's disease annual percentage change [APC] = 3.4%, ulcerative colitis APC = 2.8%). The increase was higher among non-Hispanic Black persons (Crohn's disease APC = 5.0%, ulcerative colitis APC = 3.5%) than it was among non-Hispanic White, Hispanic, and Asian/Pacific Islander (A/PI) persons. Prevalence was consistently highest among non-Hispanic White persons for both diseases and lowest among A/PI persons for Crohn's disease. The study findings of increasing prevalence in all racial/ethnic groups among older adults, especially the higher rate of increase among certain racial/ethnic minority groups, underscore the importance for promoting health equity, guiding efforts to tailor disease management strategies for different populations, and continuing to monitor the temporal trends of the disease.
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http://dx.doi.org/10.15585/mmwr.mm7019a2DOI Listing
May 2021

Inhibition of CTCF-regulated miRNA-185-5p mitigates renal interstitial fibrosis of chronic kidney disease.

Epigenomics 2021 May 12. Epub 2021 May 12.

Clinical Laboratory, Yijishan Hospital of Wannan Medical College, Wuhu 241001, PR China.

The present study aimed to elucidate the effect of CTCF on renal interstitial fibrosis in chronic kidney disease (CKD) and underlying mechanisms. We measured NPHS2 expression and investigated its function in a unilateral ureteral obstruction-induced mouse model of CKD. NPHS2 was poorly expressed in CKD mice. miR-185-5p targeted NPHS2 and reduced its expression, leading to increased α-SMA and COL I/III expression, increased renal interstitial fibrosis area and elevated phosphorylated vasodilator-stimulated phosphoprotein/vasodilator-stimulated phosphoprotein ratio. Cotreatment with CTCF downregulated miR-185-5p expression and abolished its effects in the CKD model. CTCF suppressed miR-185-5p and upregulated its target NPHS2, with a net effect of alleviating renal interstitial fibrosis in CKD.
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http://dx.doi.org/10.2217/epi-2020-0243DOI Listing
May 2021

JTE-013 Alleviates Inflammatory Injury and Endothelial Dysfunction Induced by Sepsis In Vivo and Vitro.

J Surg Res 2021 May 7;265:323-332. Epub 2021 May 7.

Special Functions Section, The Fourth Sanatorium Area of Hangzhou Special Service Sanatorium Center of Air Force, Nanjing City, Jiangsu Province, China. Electronic address:

Background: Nowadays, there is no approved targeted agent for lung injury induced by sepsis. S1PR2 is confirmed to be a promising diagnosis and treatment target. JTE-013 as S1PR2 antagonists may be an agent of great potential. In this research, we sought to determine the functional role of JTE-013 in lung injury induced by sepsis.

Materials And Methods: Seventy-two rats were assigned into normal group, sepsis model group and JTE-013 group. The animal model of lung injury induced by sepsis was constructed by cecal ligation and puncture. The human pulmonary microvascular endothelial cells (HPMECs) were divided into control, LPS and LPS + JTE-013 group. HPMECs induced by LPS served as the cell model of lung injury induced by sepsis. HE staining assay was performed for assessment of the pathological condition and Evans blue was applied for assessment of pulmonary tissue permeability. Wet/dry ratio was measured as indicators of pulmonary edema degree and neutrophil count was measured as indicators of infection status. The levels of inflammatory factors were detected by corresponding kits, cell survival by CCK-8 assay and protein expression level by western blot.

Results: S1PR2 was highly expressed in vivo model of lung injury induced by sepsis. It was observed that JTE-013 as antagonist of S1PR2 alleviated the lung tissue injury, endothelial dysfunction and pulmonary edema induced by sepsis. In addition, JTE-013 reduced neutrophil count and levels of inflammatory factors. Moreover, results confirmed that JTE-013 enhanced cell viability and mitigated inflammatory response in cell model of sepsis.

Conclusions: Overall, JTE-013 as an antagonist of S1PR2 could relieve inflammatory injury and endothelial dysfunction induced by sepsis in vivo and vitro, resulting in attenuation of lung injury. These findings elucidated that JTE-013 may be a promising targeted agent for lung injury induced by sepsis.
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http://dx.doi.org/10.1016/j.jss.2021.03.006DOI Listing
May 2021

Degradation of sulfamerazine by a novel CuO@C composite derived from Cu-MOFs under air aeration.

Chemosphere 2021 May 4;280:130678. Epub 2021 May 4.

College of Chemistry and Materials Science, Sichuan Normal University, Chengdu, 610066, China; Key Laboratory of Treatment for Special Wastewater of Sichuan Province Higher Education System, Sichuan, Chengdu, 610066, China. Electronic address:

Most metal-organic frameworks (MOFs) are synthesized from carboxylate and metal precursors by hydrothermal process, which will consume a large amount of solvent and carboxylate. To address this issue, a new strategy for Cu-based MOFs was developed, in which the Cu-based MOFs was obtained by using abundant natural polymer (tannic acid) as one of the precursors and using high-energy ball milling to achieve a self-assembly of tannic acid and copper sulfate. Based on this strategy, a novel Cu-based MOFs derivative (CuO@C composite) was synthesized by high-temperature sintering of Cu-based MOFs and used for sulfamerazine (SMR) removal via O activation. The BET specific surface area and average pore size of CuO@C composite were 110.34 m g and 21.06 nm, respectively, which made CuO@C composite had the maximum adsorption capacity (Q) for SMR of 104.65 mg g and favored the subsequent degradation of SMR. The results from XRD and XPS indicated that CuO@C composite contained a lot of Cu and CuO with the sizes of 76.6 nm and 9.8 nm, respectively, which led to its high performance of O activation. The removal efficiency of SMR and 90.2% TOC achieved 100% and 90.2%, respectively in the CuO@C/air system at initial pH of 4.0, air flow rate of 100 mL min, CuO@C dosage of 1 g L and reaction time of 30 min. Reactive species, including HO, OH and O radicals were detected in the CuO@C/air system, and OH and O were mainly responsible for the degradation of SMR.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130678DOI Listing
May 2021

Early discrimination between tumor-induced rickets/osteomalacia and X-linked hypophosphatemia in Chinese children and adolescents: a retrospective case-control study.

J Bone Miner Res 2021 May 10. Epub 2021 May 10.

Department of Endocrinology, Laboratory of Endocrinology, National Commission of Health, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing, 100730, China.

In children and adolescents distinguishing tumor-induced rickets/osteomalacia (TIR/O) from hereditary hypophosphatemic rickets/osteomalacia (HR/O) is a medical challenge. We retrospectively studied 10 Chinese children and adolescents with TIR/O who underwent surgery at a mean age of 17.4 ± 2.1 years, and compared their characteristics to 24 age- and gender-matched patients with X-linked hypophosphatemia (XLH). Positive family history of HR/O and dental problems, such as enamel hypoplasia and dental abscess, were reported in 8 (33.3%) and 5 (20.8%) patients with XLX, respectively, but not in patients with TIR/O. In addition, in comparison with XLH patients, TIR/O patients had an older disease onset age (150 versus 24 months, p < 0.001), a higher height SDS (-1.2 ± 1.8 versus -4.0 ± 1.4, p < 0.001), a lower Z-score of bone mineral density (BMD) at lumbar spine (LS) (-3.9 [6.0] versus +1.8 [7.0], p < 0.001) and a higher serum intact FGF23 level (500.27 ± 87.20 versus 121.71 ± 70.94 pg/mL, p < 0.001), corresponding to a lower serum phosphate level (0.52 ± 0.07 versus 0.64 ± 0.11 mmol/L, p = 0.005) and a higher serum ALP level (557 [631] versus 305 [249] U/L, p = 0.005). We generated Receiver Operating Characteristic (ROC) curves and calculated the area under the ROC curve (AUC). The AUCs of onset age, FGF23 and LS Z-score were equal to 1, suggesting that these are excellent indices for the differential diagnosis between TIR/O and XLH. In summary, our study furthers our understanding of the spectrum of clinical, biochemical, and pathologic findings associated with TIR/O. For children and adolescent patients with HR/O, a comprehensive and careful clinical and laboratory evaluation is of great importance, and we recommend enquiry of the family history, onset age, and dental problems, as well as measurement of serum FGF23 and BMD. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/jbmr.4331DOI Listing
May 2021

Clinical diagnosis of severe COVID-19: A derivation and validation of a prediction rule.

World J Clin Cases 2021 May;9(13):2994-3007

Shenzhen Hospital, Southern Medical University, Shenzhen 518000, Guangdong Province, China.

Background: The widespread coronavirus disease 2019 (COVID-19) has led to high morbidity and mortality. Therefore, early risk identification of critically ill patients remains crucial.

Aim: To develop predictive rules at the time of admission to identify COVID-19 patients who might require intensive care unit (ICU) care.

Methods: This retrospective study included a total of 361 patients with confirmed COVID-19 by reverse transcription-polymerase chain reaction between January 19, 2020, and March 14, 2020 in Shenzhen Third People's Hospital. Multivariate logistic regression was applied to develop the predictive model. The performance of the predictive model was externally validated and evaluated based on a dataset involving 126 patients from the Wuhan Asia General Hospital between December 2019 and March 2020, by area under the receiver operating curve (AUROC), goodness-of-fit and the performance matrix including the sensitivity, specificity, and precision. A nomogram was also used to visualize the model.

Results: Among the patients in the derivation and validation datasets, 38 and 9 participants (10.5% and 2.54%, respectively) developed severe COVID-19, respectively. In univariate analysis, 21 parameters such as age, sex (male), smoker, body mass index (BMI), time from onset to admission (> 5 d), asthenia, dry cough, expectoration, shortness of breath, asthenia, and Rox index < 18 (pulse oxygen saturation, SpO)/(FiO × respiratory rate, RR) showed positive correlations with severe COVID-19. In multivariate logistic regression analysis, only six parameters including BMI [odds ratio (OR) 3.939; 95% confidence interval (CI): 1.409-11.015; = 0.009], time from onset to admission (≥ 5 d) (OR 7.107; 95%CI: 1.449-34.849; = 0.016), fever (OR 6.794; 95%CI: 1.401-32.951; = 0.017), Charlson index (OR 2.917; 95%CI: 1.279-6.654; = 0.011), PaO/FiO ratio (OR 17.570; 95%CI: 1.117-276.383; = 0.041), and neutrophil/lymphocyte ratio (OR 3.574; 95%CI: 1.048-12.191; = 0.042) were found to be independent predictors of COVID-19. These factors were found to be significant risk factors for severe patients confirmed with COVID-19. The AUROC was 0.941 (95%CI: 0.901-0.981) and 0.936 (95%CI: 0.886-0.987) in both datasets. The calibration properties were good.

Conclusion: The proposed predictive model had great potential in severity prediction of COVID-19 in the ICU. It assisted the ICU clinicians in making timely decisions for the target population.
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http://dx.doi.org/10.12998/wjcc.v9.i13.2994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8080753PMC
May 2021

A characterization and prognosis prediction model for primary squamous cell carcinoma of the thyroid.

Gland Surg 2021 Apr;10(4):1325-1338

Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.

Background: Primary squamous cell carcinoma of the thyroid (PSCCTh) is a sporadic malignancy arising from the thyroid gland. The factors that affect treatment and survival in patients with PSCCTh remain unclear. Our study aims to characterize PSCCTh and establish a prognosis prediction model for patients with PSCCTh.

Methods: Clinical data and follow-up information for 277 patients from 1973 to 2016 were collected from the Surveillance, Epidemiology, and End Results Program (SEER) 18-registry database (RRID:SCR_003293). Univariate and multivariate Cox proportional hazards analyses and nomogram modeling of potential prognostic factors were conducted.

Results: Among the collected patient cases, 57% were female and 43% were male. The median survival of all cases was 6 months; by gender, median survival was 5 and 8 months in the female and male groups, respectively. Univariate and multivariate Cox proportional hazards analyses revealed that age, extent of disease (EOD), T stage, N stage, and treatment were independent prognostic indicators for overall survival (OS) and disease-specific survival (DSS) in patients with PSCCTh. In addition, it was confirmed that the established nomogram model had good consistency and discrimination for PSCCTh prognosis as measured by the concordance index (C-index), area under the receiver operating characteristic (ROC) curve (AUC), and calibration curves.

Conclusions: Our study indicates that age, EOD, T stage, N stage, and treatment may correlate with OS and DSS in patients with PSCCTh. Importantly, our nomogram prediction model, constructed using parameters including age, T stage, N stage, and treatment, may assist physicians in evaluating patients' prognoses and providing precise therapy for PSCCTh.
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http://dx.doi.org/10.21037/gs-20-847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8102235PMC
April 2021

Effects of respiratory muscle training on cough function in neurological disorders: A systematic review with meta-analysis.

NeuroRehabilitation 2021 May 3. Epub 2021 May 3.

Department of Pain and Rehabilitation, Xinqiao Hospital, Army Medical University, Chongqing, China.

Background: Patients with neurological disorders can present the weakness of respiratory muscle and impaired cough function. Previous studies have shown that respiratory muscle strength training (RMT) is an effective method of improving the strength of respiratory muscle. The effects of RMT on cough function remain controversial.

Objective: We aimed to analyze randomized controlled trials (RCTs) that investigated the effects of RMT on cough function of patients with neurological disorders.

Methods: Pubmed, Medline, Embase, and the Cochrane Library were searched electronically for RCTs. Two reviewers independently performed data extraction and quality assessment. Data were analyzed by using RevMan 5.3 software of The Cochrane Collaboration.

Results: Five studies with 185 participants were included. The mean PEDro score was 6.2 (range 5 to 7), showing moderate methodological quality. Random-effects meta-analyses showed that respiratory muscle training improved peak expiratory cough flow of voluntary cough by 2.16 (95% CI 1.16 to 3.17) and involuntary cough by 2.84 (95% CI 1.29 to 4.39), with statistical significance (P <  0.0001, P = 0.0003). The experimental group had an improvement of 0.19 cmH2O (95% CI -0.12 to 0.5) on the maximal inspiratory pressure, 0.09 cmH2O (95% CI -0.23 to 0.42) on the maximal expiratory pressure, but with no statistical significance (P = 0.23, P = 0.58) between groups.

Conclusion: Respiratory muscle training was considered as an effective method for improving cough function. However, this review was insufficient to conclude whether respiratory muscle training was effective in improving inspiratory and expiratory muscle strength, this was opposite with previous meta-analysis. These effects might due to the small samples and different diseases.
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http://dx.doi.org/10.3233/NRE-210017DOI Listing
May 2021

Structural characterization and anti-inflammatory activity of a polysaccharide from the lignified okra.

Carbohydr Polym 2021 Aug 15;265:118081. Epub 2021 Apr 15.

Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei 230009, People's Republic of China; School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China. Electronic address:

The polysaccharide (AP1-b) of molecular weight 6.59 × 10 Da was isolated from lignified okra (Abelmoschus esculentus (L.) Moench) by hot-water extraction, 40 % ethanol precipitation and purified by DEAE Cellulose chromatography, respectively. The structure and anti-inflammatory activity of AP1-b were investigated. AP1-b was composed of galactose, rhamnose, gluctose, arabinose and galacturonic acid in a molar ratio of 1.98:1.00:0.15:0.32:0.29. The structural features showed that the AP1-b consisted of →2)-α-d-Rhap-(1→, →4)-β-d-Galp-(1→, →4)-α-d-GalpA-(1→, →6)-β-d-Galp-(1→, β-d-Glcp-(1→ and α-l-Araf-(1→. AP1-b could observably improve the inflammatory injury of LPS-induced RAW 264.7 cells by inhibiting the secretion of NO and decreasing the levels of pro-inflammatory factors (IL-1β, iNOS and TNF-α). AP1-b also inhibited the phosphorylation levels of IκB and p65 proteins, manifesting the anti-inflammatory activity of AP1-b may associated with inhibition of NF-κB signaling pathway. Therefore, AP1-b had potential value in treating inflammatory injury.
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http://dx.doi.org/10.1016/j.carbpol.2021.118081DOI Listing
August 2021

Residue changes and processing factors of eighteen field-applied pesticides during the production of Chinese Baijiu from rice.

Food Chem 2021 Apr 29;359:129983. Epub 2021 Apr 29.

Longping Branch, Graduate School of Hunan University, Changsha 410125, China; Hunan Plant Protection Institute, Hunan Academy of Agricultural Science, Changsha 410125, China. Electronic address:

The fate of eighteen pesticides in field-collected rice samples during Chinese Baijiu production was systematically studied. The results indicated that steeping decreased flonicamid residue by 73.2% due to its high water-solubility and low octanol/water partition coefficient. The steaming step reduced pesticide residues by 32.0%-75.3% through evaporation or thermal degradation. After steaming, the pesticide residues were further reduced by 39.8-74.2% in fermentation which might be caused by biological degradation. In addition, distillation was shown to be most effective, responsible for greater than 90% losses of the remaining pesticide residues. The processing factors (PFs) were generally lower than 1 for different processes and the whole procedure. These results revealed that the procedure of Chinese Baijiu production could dramatically decrease residues of all the eighteen pesticides. Overall, this study provide important references for monitoring pesticide residue levels during the production of Chinese Baijiu from rice, and ensuring proper risk assessment from pesticide contamination.
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http://dx.doi.org/10.1016/j.foodchem.2021.129983DOI Listing
April 2021

Graphene-Based Polarization-Independent Mid-Infrared Electro-Absorption Modulator Integrated in a Chalcogenide Glass Waveguide.

Nanoscale Res Lett 2021 May 8;16(1):80. Epub 2021 May 8.

School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 610054, China.

A polarization-insensitive graphene-based mid-infrared optical modulator is presented that comprised SiO/ GeSbS, in which two graphene layers are embedded with a semiellipse layout to support transverse magnetic (TM) and transverse electric (TE) polarizing modes with identical absorption. The key performance index for the polarization independent modulator is polarization-sensitivity loss (PSL). The waveguide of our device just supports basic TE and TM modes, and the PSL between two modes is of < 0.24 dB. The model can offer extinction ratio (ER) more than 16 dB and insertion loss less than 1 dB. The operation spectrum ranges from 2 to 2.4 μm with optical bandwidth of 400 nm. The 3 dB modulation bandwidth is as high as 136 GHz based on theoretical calculation.
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http://dx.doi.org/10.1186/s11671-021-03538-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106561PMC
May 2021

Heme oxygenase-1 induction mitigates burn-associated early acute kidney injury via the TLR4 signaling pathway.

Burns 2021 Apr 24. Epub 2021 Apr 24.

Department of Burns, The Second Affiliated Hospital Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou 310009, Zhejiang, China. Electronic address:

Objectives: Early acute kidney injury (AKI) after burn contributes to disastrous prognoses for severely burned patients. Burn-induced renal oxidative stress and secondary proinflammatory mediator release contribute to early AKI development, and Toll-like receptor (TLR) 4 regulates inflammation. Heme oxygenase-1 (HO-1) is a stress-responsive enzyme that plays a vital role in protecting against ischemia-induced organ injury via its antioxidant properties and regulation of inflammation. We investigated the potential effect of HO-1 induction in preventing burn-induced early AKI and its related mechanism.

Methods: A classic major-burn rat model was established using a 100 °C water bath, and hemin was injected intraperitoneally immediately after the injury to induce HO-1. Histological staining and blood tests were used to assess AKI progression based on structural changes and function. Renal levels of HO-1, oxidative stress, proinflammatory mediators and TLR4-related signals were detected using ELISA, immunostaining, qRT-PCR, and western blotting. The selective TLR4 inhibitor TAK242 and TLR4 inducer LPS were introduced to determine the roles of HO-1 in burn-related renal inflammation and the TLR4 pathway.

Results: Hemin improved burn-induced renal histological damage and dysfunction, and this beneficial effect was related to reduced renal oxidative stress and the release of proinflammatory mediators, such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, IL-6 and intracellular adhesion molecule-1 (ICAM-1). Hemin downregulated the expression of TLR4 and the subsequent phosphorylation of IKKα/β, IκBα, and NF-κB p65;. TAK242 exerted an effect similar to but weaker than hemin; and LPS reversed the antiinflammatory effect of hemin and the regulation of TLR4 signals. These results suggested that the TLR4 signaling pathway mediated the HO-1-facilitated regulation of renal inflammation after burn.

Conclusion: The present study demonstrated that HO-1 induction prevented burn-induced early AKI by targeting renal inflammation, which was mediated via regulation of the TLR4/NF-κB signaling pathway.
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http://dx.doi.org/10.1016/j.burns.2021.04.013DOI Listing
April 2021

A deep learning-based auto-segmentation system for organs-at-risk on whole-body computed tomography images for radiation therapy.

Radiother Oncol 2021 May 4. Epub 2021 May 4.

Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Background And Purpose: Delineating organs at risk (OARs) on computed tomography (CT) images is an essential step in radiation therapy; however, it is notoriously time-consuming and prone to inter-observer variation. Herein, we report a deep learning-based automatic segmentation (AS) algorithm (WBNet) that can accurately and efficiently delineate all major OARs in the entire body directly on CT scans.

Materials And Methods: We collected 755 CT scans of the head and neck, thorax, abdomen, and pelvis and manually delineated 50 OARs on the CT images. The CT images with contours were split into training and test sets consisting of 505 and 250 cases, respectively, to develop and validate WBNet. The volumetric Dice similarity coefficient (DSC) and 95th-percentile Hausdorff distance (95% HD) were calculated to evaluate delineation quality for each OAR. We compared the performance of WBNet with three AS algorithms: one commercial multi-atlas-based automatic segmentation (ABAS) software, and two deep learning-based AS algorithms, namely, AnatomyNet and nnU-Net. We have also evaluated the time saving and dose accuracy of WBNet.

Results: WBNet achieved average DSCs of 0.84 and 0.81 on in-house and public datasets, respectively, which outperformed ABAS, AnatomyNet, and nnU-Net. WBNet could reduce the delineation time significantly and perform well in treatment planning, with clinically acceptable dose differences compared with those in manual delineation.

Conclusion: This study shows the feasibility and benefits of using WBNet in clinical practice.
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http://dx.doi.org/10.1016/j.radonc.2021.04.019DOI Listing
May 2021

Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations.

Chem Biol Interact 2021 May 4;343:109498. Epub 2021 May 4.

School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, 124221, China. Electronic address:

The drug-drug interaction (DDI) risk of phenytoin with several topical formulations of miconazole is still unclear. The present investigation conducted in vitro-in vivo extrapolation to predict the potential risks. Our data indicated that miconazole potently inhibited phenytoin hydroxylation in both pooled human liver microsomes (HLMs) and recombinant cytochrome P450 2C9 (CYP2C9) with the K values of 125 ± 7 nM and 30 ± 2 nM, respectively. Quantitative prediction of DDI risk suggests that, beside intravenous administration or swallowed tablet, combination of phenytoin and miconazole high dose oral gel or buccal tablet may also result in a clinically significant increase of phenytoin AUC (>53%) by the inhibition of miconazole against phenytoin hydroxylation, consequently a higher frequency of adverse events, while the coadministration of miconazole vaginal formulation and phenytoin will be safe.
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http://dx.doi.org/10.1016/j.cbi.2021.109498DOI Listing
May 2021

Diet Quality and Visceral Adiposity among a Multiethnic Population of Young, Middle, and Older Aged Adults.

Curr Dev Nutr 2020 Jun 26;4(6):nzaa090. Epub 2020 May 26.

University of Hawaii Cancer Center, Honolulu, HI.

Background: Visceral adiposity, more so than overall adiposity, is associated with chronic disease and mortality. There has been, to our knowledge, little research exploring the association between diet quality and visceral adipose tissue (VAT) among a mulitethnic population aged 18-80 y.

Objective: The primary objective of this cross-sectional analysis was to examine the association between diet quality [Healthy Eating Index-2010 (HEI-2010) scores] and VAT among a multiethnic population of young, middle, and older aged adults in the United States. Secondary objectives were to repeat these analyses with overall adiposity and blood-based biomarkers for type 2 diabetes and cardiovascular disease risk as outcome measures.

Methods: A total of 540 adults (dropped out:  = 4; age: 18-40 y,  = 220; 40-60 y,  = 183; 60-80 y,  = 133) were recruited across 3 sites (Honolulu County, San Francisco, and Baton Rouge) for the Shape Up! Adults study. Whole-body DXA, anthropometry, fasting blood draw, and questionnaires (food frequency, physical activity, and demographic characteristics) were completed. Linear regression was used to assess the associations between HEI-2010 tertiles and VAT and secondary outcome measures among all participants and age-specific strata, while adjusting for known confounders.

Results: VAT, BMI (kg/m), body fat percentage, total body fat, trunk fat, insulin, and insulin resistance were inversely related to diet quality (all values < 0.004). When stratified by age, diet quality was inversely associated with VAT among participants aged 60-80 y ( < 0.006) and VAT/subcutaneous adipose tissue (SAT) among participants aged 40-60 y ( < 0.008).

Conclusions: Higher-quality diet was associated with lower VAT, overall adiposity, and insulin resistance among this multiethnic population of young, middle, and older aged adults with ages ranging from 18 to 80 y. More specifically, adherence to a high-quality diet may minimize VAT accumulation in adults aged 60-80 y and preferentially promote storage of SAT compared with VAT in adults aged 40-60 y.This study was registered at clinicaltrials.gov as NCT03637855.
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http://dx.doi.org/10.1093/cdn/nzaa090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8082229PMC
June 2020

Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography.

J Interv Cardiol 2021 8;2021:6641887. Epub 2021 Mar 8.

Department of Cardiology, Dongguan TCM Hospital, Dongguan 523000, China.

Background: Contrast-associated acute kidney injury (CA-AKI) is a common complication in patients undergoing coronary angiography (CAG). However, few studies demonstrate the association between the prognosis and developed CA-AKI in the different periods after the operation.

Methods: We retrospectively enrolled 3206 patients with preoperative serum creatinine (Scr) and at least twice SCr measurement after CAG. CA-AKI was defined as an increase ≥50% or ≥0.3 mg/dL from baseline in the 72 hours after the procedure. Early CA-AKI was defined as having the first increase in SCr within the early phase (<24 hours), and late CA-AKI was defined as an increase in SCr that occurred for the first time in the late phase (24-72 hours). The first endpoint of this study was long-term all-cause mortality. Kaplan-Meier analysis was used to count the cumulative mortality, and the log-rank test was used to assess differences between curves. Univariate and multivariate cox regression analyses were performed to assess whether patients who developed different type CA-AKI were at increased risk of long-term mortality.

Results: The number of deaths in the 3 groups was 407 for normal (12.7%), 106 for early CA-AKI (32.7%) and 57 for late CA-AKI (17.7%), during a median follow-up period of 3.95 years. After adjusting for important clinical variables, early CA-AKI (HR = 1.33, 95% CI: 1.02-1.74, =0.038) was significantly associated with mortality, while late CA-AKI (HR = 0.92, 95% CI: 0.65-1.31, =0.633) was not. The same results were found in patients with coronary artery disease, chronic kidney disease, diabetes mellitus, and percutaneous coronary intervention.

Conclusions: Early increases in Scr, i.e., early CA-AKI, have better predictive value for long-term mortality. Therefore, in clinical practice, physicians should pay more attention to patients with early renal injury related to long-term prognosis and give active treatment.
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http://dx.doi.org/10.1155/2021/6641887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8074549PMC
March 2021

Association between baseline LDL-C and prognosis among patients with coronary artery disease and advanced kidney disease.

BMC Nephrol 2021 May 6;22(1):168. Epub 2021 May 6.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.

Background: Lower low-density lipoprotein cholesterol (LDL-C) is significantly associated with improved prognosis in patients with coronary artery disease (CAD). However, LDL-C reduction does not decrease all-cause mortality among CAD patients when renal function impairs. The association between low baseline LDL-C (< 1.8 mmol/L) and mortality is unknown among patients with CAD and advanced kidney disease (AKD). The current study aimed to evaluate prognostic value of low baseline LDL-C level for all-cause death in these patients.

Methods: In this observational study, 803 CAD patients complicated with AKD (eGFR < 30 mL/min/1.73 m) were enrolled between January 2008 to December 2018. Patients were divided into two groups (LDL-C < 1.8 mmol/L, n = 138; LDL-C ≥ 1.8 mmol/L, n = 665). We used Kaplan-Meier methods and Cox regression analyses to assess the association between baseline low LDL-C levels and long-term all-cause mortality.

Results: Among 803 participants (mean age 67.4 years; 68.5% male), there were 315 incidents of all-cause death during a median follow-up of 2.7 years. Kaplan-Meier analysis showed that low LDL-C levels were associated with worse prognosis. After adjusting for full 24 confounders (e.g., age, diabetes, heart failure, and dialysis, etc.), multivariate Cox regression analysis revealed that lower LDL-C level (< 1.8 mmol/L) was significantly associated with higher risk of all-cause death (adjusted HR, 1.38; 95% CI, 1.01-1.89).

Conclusions: Our data demonstrated that among patients with CAD and AKD, a lower baseline LDL-C level (< 1.8 mmol/L) did not present a higher survival rate but was related to a worse prognosis, suggesting a cautiousness of too low LDL-C levels among patients with CAD and AKD.
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http://dx.doi.org/10.1186/s12882-021-02375-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101096PMC
May 2021

Association between Diabetes Mellitus and Contrast-Associated Acute Kidney Injury: A Systematic Review and Meta-Analysis of 1.1 Million Contrast Exposure Patients.

Nephron 2021 May 5:1-11. Epub 2021 May 5.

Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangzhou, China.

Background: Although diabetes mellitus (DM) has been a common risk factor of contrast-associated acute kidney injury (CA-AKI) for a long time, several current studies showed that DM is not an independent risk factor. Due to this diverse finding, we aim to conduct a systematic review assessing the effect of DM on CA-AKI.

Methods: We searched Ovid Medline, Embase, and Cochrane Database of Systematic Reviews (to June 1, 2020) for studies assessing the association between DM and CA-AKI. Random meta-analysis was performed to derive the pooled estimates of the adjusted odds ratio (OR) and corresponding 95% confidence intervals (CIs).

Results: A total of 84 studies involving 1,136,827 participants were included in this meta-analysis. The presence of DM was associated with an higher risk of CA-AKI (pooled OR: 1.58, 95% CI: 1.48-1.70, I2 = 64%). Furthermore, the predictive effect of elevated CA-AKI for was stronger in the subgroup of DM patients with chronic kidney disease (CKD) (OR: 2.33, 95% CI: 1.21-4.51), while the relationship between DM and CA-AKI was not significant in subgroup patients without CKD (OR: 1.12, 95% CI: 0.73-1.72).

Conclusion: This is the first meta-analysis to prove that DM is an independent risk factor of CA-AKI in patients. While the predictive value of DM for CA-AKI in patients with normal kidney function was weakened, more protective treatments are needed in diabetic patients with kidney dysfunction to avoid the occurrence of CA-AKI.
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http://dx.doi.org/10.1159/000515906DOI Listing
May 2021

Establishment and verification of prognostic model for gastric cancer based on autophagy-related genes.

Am J Cancer Res 2021 15;11(4):1335-1346. Epub 2021 Apr 15.

Department of Gastroenterology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer Tianjin 300060, P. R. China.

Autophagy played a significant role in the development of cancer. In this study, we explored the value of autophagy-associated genes in gastric cancer. RNA sequencing and clinical information containing 375 gastric cancer and 32 normal tissues were gathered from the TCGA portal. Then we stochastically allocated the autophagy-associated genes (AAGs) to training and testing groups. Next, we screened the discrepantly expressed AAGs and the prognostic AAGs by Cox regression analysis and Lasso regression analysis. Afterwards, we structured the model by using the prognostic AAGs and plotted Kaplan-Meier (KM) and receiver operating characteristic (ROC) curves to verify the performance of models in both groups. Besides, we utilized Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses to explore the molecular mechanisms of AAGs in gastric cancer. Finally, we demonstrated discrepant expression of AAGs within gastric cancer and non-tumor tissues at protein level with immunohistochemistry. 28 discrepantly expressed AAGs were screened from the TCGA database which contained 375 gastric cancer and 32 non-tumor samples. Cox and Lasso regression analyses were performed in training group and then we got 5 prognostic AAGs to establish the prognostic model. The patients who had high risk possessed worse overall survival (OS) both in training group (5-year OS, 47.6% vs 23.1%; P < 0.0001) and test group (5-year OS, 49.2% vs 0%, P=0.019). The proportion under ROC curves (AUC) were significant both in training group and test group (5-year AUC, 0.736 vs 0.809). Through this study, we constructed a model for gastric cancer patients which may provide individual treatment and superior prognosis.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8085875PMC
April 2021

The Cutoff Value of Low Sex Hormone-Binding Globulin and Its Predictive Role in Impaired Glucose Metabolism Among Chinese Women with Polycystic Ovarian Syndrome.

Metab Syndr Relat Disord 2021 May 4. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

Low levels of sex hormone-binding globulin (SHBG) is a potential predictor of type 2 diabetes mellitus (T2DM), and when combined with insulin resistance (IR), lead to impaired glucose metabolism. Few studies involve women with polycystic ovarian syndrome (PCOS). Studies on cutoff values of SHBG among Asian women were scanty. The cutoff level of SHBG was computed using the 25th percentile method. Parameters were compared between the lower and higher SHBG subgroup. Area under the curve (AUC) for sensitivity and specificity of SHBG in predicting IR and impaired glucose metabolism was calculated. This study included 733 patients with PCOS 20-45 years of age and 469 age-matched controls. The 25th percentile of SHBG in the control group was 51.90 nM. There were negative correlations between SHBG and age ( = -0.085,  < 0.05), body mass index (BMI) ( = -0.461,  < 0.01), waist-to-hip ratio (WHR) ( = -0.349,  < 0.01), fasting plasma glucose ( = -0.242,  < 0.01), Glucose-1h ( = -0.303,  < 0.01), Glucose-2h ( = -0.336,  < 0.01), fasting insulin ( = -0.324,  < 0.01), Insulin-1h ( = -0.238,  < 0.01), Insulin-2h ( = -0.307,  < 0.01), and homeostasis model 2 assessment of insulin resistance (HOMA2-IR) ( = -0.329,  < 0.01). Age, BMI, WHR, glucose and insulin levels (both pre- and postload), HOMA2-IR, free testosterone, and dehydroepiandrosterone sulfate were all higher in the lower than the higher SHBG subgroup. The AUC of SHBG for predicting IR was 0.706 [95% confidence interval (CI) 0.665-0.745,  < 0.001], impaired fasting glucose was 0.674 (95% CI 0.513-0.838,  < 0.001), impaired glucose tolerance was 0.637 (95% CI 0.586-0.690,  < 0.001), and T2DM was 0.674 (95% CI 0.556-0.780,  < 0.001). A 51.90 nM should be identified as the cutoff value of SHBG. Women with PCOS with lower SHBG values have a higher risk of developing impaired glucose metabolism. Low SHBG should be a predictive biomarker of impaired glucose metabolism in women with PCOS in southern China.
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http://dx.doi.org/10.1089/met.2020.0071DOI Listing
May 2021

Biological and Genetic Characterization of Pod Pepper Vein Yellows Virus-Associated RNA From in Wenshan, China.

Front Microbiol 2021 15;12:662352. Epub 2021 Apr 15.

State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agroproducts, Institute of Plant Virology, Ningbo University, Ningbo, China.

Tombusvirus-like associated RNAs (tlaRNAs) are positive-sense single-stranded RNAs found in plants co-infected with some viruses of the genus . Pod pepper vein yellows virus (PoPeVYV) was recently reported as a new recombinant polerovirus causing interveinal yellowing, stunting, and leaf rolling in plants at Wenshan city, Yunnan province, China. The complete genome sequence of its associated RNA has now been determined by next-generation sequencing and reverse transcription (RT) polymerase chain reaction (PCR). PoPeVYV-associated RNA (PoPeVYVaRNA) (GenBank Accession No. MW323470) has 2970 nucleotides and is closely related to other group II tlaRNAs, particularly tobacco bushy top disease-associated RNA (TBTDaRNA, GenBank Accession No. EF529625). In infection experiments on and plants, synergism between PoPeVYVaRNA and PoPeVYV was demonstrated, leading to severe interveinal yellowing of leaves and stunting of plants. The results provide further information on the genetic and biological properties of the various agents associated with pepper vein yellows disease (PeVYD).
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http://dx.doi.org/10.3389/fmicb.2021.662352DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8083956PMC
April 2021

Development and Validation of a Nomogram Based on Motoric Cognitive Risk Syndrome for Cognitive Impairment.

Front Aging Neurosci 2021 16;13:618833. Epub 2021 Apr 16.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objective: To develop and validate a prediction nomogram based on motoric cognitive risk syndrome for cognitive impairment in healthy older adults.

Methods: Using two longitudinal cohorts of participants (aged ≥ 60 years) with 4-year follow-up, we developed ( = 1,177) and validated ( = 2,076) a prediction nomogram. LASSO (least absolute shrinkage and selection operator) regression model and multivariable Cox regression analysis were used for variable selection and for developing the prediction model, respectively. The performance of the nomogram was assessed with respect to its calibration, discrimination, and clinical usefulness.

Results: The individualized prediction nomogram was assessed based on the following: motoric cognitive risk syndrome, education, gender, baseline cognition, and age. The model showed good discrimination [Harrell's concordance index (C-index) of 0.814; 95% confidence interval, 0.782-0.835] and good calibration. Comparable results were also seen in the validation cohort, which includes good discrimination (C-index, 0.772; 95% confidence interval, 0.776-0.818) and good calibration. Decision curve analysis demonstrated that the prediction nomogram was clinically useful.

Conclusion: This prediction nomogram provides a practical tool with all necessary predictors, which are accessible to practitioners. It can be used to estimate the risk of cognitive impairment in healthy older adults.
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http://dx.doi.org/10.3389/fnagi.2021.618833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8086554PMC
April 2021

Optimal Surgical Approach for the Dumbbell-Shaped Trigeminal Schwannoma.

J Craniofac Surg 2021 Apr 29. Epub 2021 Apr 29.

Department of Neurosurgery, Center of Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Abstract: Dumbbell-shaped trigeminal schwannoma afflicts the middle and posterior cranial fossa. Surgical approach for gross total resection remains highly challenging. The authors present a case of dumbbell-shaped trigeminal schwannoma treated successfully by using frontotemporal intradural approach with the removal of temporal pole. Subtotal resection was achieved as the schwannoma was closely adhered to trigeminal nerve. As a postoperative complication, abducens paralysis recovered significantly within the 3-month follow-up. No severe complication was observed. The authors suggest that frontotemporal intradural approach is optimal surgical approach as it is particularly convenient and safe.
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http://dx.doi.org/10.1097/SCS.0000000000007701DOI Listing
April 2021

Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3.

Brain Res Bull 2021 Apr 28;172:220-228. Epub 2021 Apr 28.

Institute of Neurobiology, Xi'an Jiaotong University Basic Medical School, Xi'an, 710061, Shanxi, China. Electronic address:

Objective: We aim to explore the protective effect of bone marrow mesenchymal stem cells (BMSCs)-derived exosomal microRNA-221-3p (miR-221-3p) on ischemic stroke (IS) by targeting activating transcription factor 3 (ATF3).

Methods: The middle cerebral artery occlusion (MCAO) mice model and oxygen-glucose deprivation (OGD) neuron model were established. Extracellular vesicles were isolated from BMSCs (BMSC-EVs) and transfected with altered miR-221-3p or ATF3 to treat the MCAO mice and OGD-treated neurons. MiR-221-3p and ATF3 expression were determined, and the contents of inflammatory factors were detected. The pathological changes and apoptosis in mice brain tissues were observed. In cellular experiments, the viability and apoptosis of OGD-treated neurons were evaluated. Binding relationship between miR-221-3p and ATF3 was determined.

Results: MiR-221-3p was down-regulated and ATF3 was up-regulated in MCAO mice and OGD-treated neurons. BMSC-EVs and BMSC-EVs carrying up-regulated miR-221-3p attenuated inflammation, pathological changes and apoptosis in MCAO mice brain tissues, and also promoted viability and repressed apoptosis of OGD-treated neurons. ATF3 was verified as a target of miR-221-3p.

Conclusion: BMSC-EVs carrying miR-221-3p protect against IS by inhibiting ATF3. This study may be helpful for exploring therapeutic strategies of IS.
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http://dx.doi.org/10.1016/j.brainresbull.2021.04.022DOI Listing
April 2021

Microwave pulse generation via employing an electric signal modulator to achieve time-domain mode locking in an optoelectronic oscillator.

Opt Lett 2021 May;46(9):2107-2110

An actively mode-locked optoelectronic oscillator (OEO) is proposed and demonstrated to generate chirp-free microwave pulse trains with variable repetition rates. Time-domain mode locking is realized by using an electric signal modulator to achieve amplitude modulation of the generated microwave signal in the OEO cavity. Through setting the externally applied electric signal frequency to be equal to the integral multiple of the free spectral range, a microwave pulse train with a low close-to-carrier phase noise is generated. In the experiment, microwave pulse trains with repetition rates of 179.94 and 360.00 kHz are generated through fundamental mode locking and 2nd-order harmonic mode locking, respectively. Under fundamental mode locking, the phase noise of the actively mode-locked OEO at 100 Hz frequency offset is measured to be 30 dB lower than that in a free-running OEO.
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http://dx.doi.org/10.1364/OL.422556DOI Listing
May 2021

Toward a High-Energy-Density Cathode with Enhanced Temperature Adaptability for Sodium-Ion Batteries: A Case Study of NaMnZr(PO) Microspheres with Embedded Dual-Carbon Networks.

ACS Appl Mater Interfaces 2021 May 30;13(18):21390-21400. Epub 2021 Apr 30.

Collaborative Innovation Center of Sustainable Energy Materials, Guangxi University, Nanning 530004, P. R. China.

Polyanionic cathode materials that have high energy density and good temperature adaptability are in high demand for practical applications in sodium-ion batteries (SIBs). In this study, a scalable spray-drying strategy has been proposed to construct interconnected conductive networks composed of amorphous carbon and reduced graphene oxide in NaMnZr(PO) microspheres (NMZP@C-rGO). The dual-carbon conductive networks provide fast electron migration pathways in the microspheres. Moreover, they significantly increase the porosity and specific surface area of the microspheres, which are conducive to accommodating the volume change and improving the electrode/electrolyte contact interface and the contribution of the pseudocapacitance effect to achieve fast sodium storage. As a result, NMZP@C-rGO exhibits excellent rate performance (50.9 mAh g at 50C and 30 °C, 35.4 mAh g at 50C and -15 °C) and long-term cycling stability (capacity retentions of 97.4 and 79.6% after 1500 cycles at 30 and -15 °C, respectively) in a wide temperature range.
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http://dx.doi.org/10.1021/acsami.1c03642DOI Listing
May 2021