Publications by authors named "Yong Hyun Jang"

98 Publications

Protectin D1 reduces imiquimod-induced psoriasiform skin inflammation.

Int Immunopharmacol 2021 Jun 18;98:107883. Epub 2021 Jun 18.

CMRI, Departments of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Specialized proresolving mediators are enzymatically oxygenated natural molecules derived from polyunsaturated fatty acids and are considered novel. These novel mediators include lipoxins from arachidonic acid, resolvins and protectins from omega-3 essential fatty acids, and new maresins. These mediators harbor potent dual proresolving and anti-inflammatory properties. Resolvins and protectins are known to be potent when administered to various inflammation-associated animal models of human diseases. Although psoriasis' etiology remains unknown, there is accumulating evidence indicating that cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-23, and IL-17, play pivotal roles in its development. Experimentally, resolvins, maresins, and lipoxins downregulate the cytokine expression of the IL-23/IL-17 axis and inhibition of mitogen-activated protein kinases and nuclear factor kappa-light-chain-enhancer of activated B (NF-κB) cell signaling transduction pathways. Here, we assessed the effects of protectin D1 (PD1) on imiquimod (IMQ)-induced psoriasiform skin inflammation and keratinocytes. PD1 showed clinical improvement in skin thickness, redness, and scaling in psoriasis mouse models. Moreover, PD1 decreased IL-1β, IL-6, IL-17, and CXCL1 mRNA expressions and reduced STAT1 and NF-κB signaling pathway activation in lesions. Serum myeloperoxidase, IgG2a, IL-1β, IL-6, IL-17, and TNF-α and spleen CD4IFN-γIL-17 T lymphocytes were reduced after PD1 treatment in IMQ-induced psoriasiform mouse models. In addition, IL-1β, IL-6, IL-8, and IL-18BP gene expressions were decreased in PD1-treated keratinocytes. Moreover, a decrease in the expression levels of CCL17 and IL-6 and an inhibition of the STAT1 and NF-κB signaling transduction pathways was observed in keratinocytes. These PD1 anti-inflammatory effects suggest that it is a good therapeutic candidate for psoriasis.
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http://dx.doi.org/10.1016/j.intimp.2021.107883DOI Listing
June 2021

Participants' Satisfaction with the Atopic Dermatitis Education Program: Assessing the Impact of Each Content Using Structural Equation Modeling.

Ann Dermatol 2021 Jun 4;33(3):237-244. Epub 2021 May 4.

Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: Only a few studies have tried to assess factors relevant to the satisfaction of the participants in atopic dermatitis (AD) educational programs. More systematic modeling of this issue is needed.

Objective: To examine the benefit of a conjoint educational program for AD on patients and caregivers in a clinical setting.

Methods: In a half-day educational program called "AD school", 831 people (493 patients and 338 family members) participated for 8 years. Various educational and entertaining programs were provided. The on-site survey was administered to measure participants' satisfaction and perception of the benefit. We applied structural equation modeling to identify the relations among satisfaction and perception.

Results: A total of 209 family survey data was obtained and analyzed. The survey items were grouped into four categories. The categories were classified as individual education, group education, fun activity, and overall satisfaction (fun, benefit, intention to re-join and recommend to others). According to the model that we built, comprehensive group education was demonstrated to be the most relevant factor affecting overall satisfaction.

Conclusion: Our holistic approach would allow dermatologists to improve the efficacy of the conjoint educational program for AD.
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http://dx.doi.org/10.5021/ad.2021.33.3.237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8137320PMC
June 2021

Association between Alopecia Areata and Comorbid Allergies: Implications for Its Clinical Course.

Ann Dermatol 2020 Dec 11;32(6):523-525. Epub 2020 Nov 11.

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2020.32.6.523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875230PMC
December 2020

Analysis of Adult Patients with Tinea Capitis in Southeastern Korea.

Ann Dermatol 2020 Apr 11;32(2):109-114. Epub 2020 Mar 11.

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

Background: Tinea capitis is a cutaneous infection of dermatophytes and predominant in children. Although tinea capitis in Korea is controlled by oral antifungal medications and concerted public health initiatives, it's still a health issue.

Objective: To investigate changes in the epidemiological and mycological characteristics of adult patients with tinea capitis in southeastern Korea.

Methods: Using medical records from Kyungpook National University Hospital and Catholic Skin Clinic from 1989 to 2018, we retrospectively investigated the epidemiological and mycological characteristics of 266 adult patients (aged over 20) with tinea capitis.

Results: Among total 266 patients, 239 were KOH-positive. The annual incidence of tinea capitis ranged from 3 to 18 between 1989 and 2018. Of the total, 54 (20.30%) were male and 212 (79.70%) were female. Eighty patients (30.08%) were in their seventies, the most commonly affected age group. Of the remaining, 58 (21.80%) were in their sixties, and 41 (15.41%) in eighties. Among all, 77 (28.95%) visited the hospital in summer, 72 (27.07%) in spring, 64 (24.06%) in winter, and 53 (19.92%) in fall. Dermatophytes were cultured from 171 patients. was the most common dermatophyte (42.48%), while was the second (15.79%). Of the 266 patients, 186 (69.92%) lived in urban areas and 80 (30.08%) in rural areas.

Conclusion: The epidemiological and mycological characteristics of adult patients with tinea capitis were different from those of children in terms of annual incidence, sex distribution, and isolated dermatophytes. These results provide useful information for the treatment and prevention of tinea capitis.
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http://dx.doi.org/10.5021/ad.2020.32.2.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992550PMC
April 2020

A retrospective case series of 10 patients with malignant melanomas arising from small- and medium-sized congenital melanocytic nevi in South Koreans.

Indian J Dermatol Venereol Leprol 2021 Mar-Apr;87(2):293-297

Department of Dermatology, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, South Korea.

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http://dx.doi.org/10.25259/IJDVL_718_19DOI Listing
October 2019

A retrospective case series of 10 patients with malignant melanomas arising from small- and medium-sized congenital melanocytic nevi in South Koreans.

Indian J Dermatol Venereol Leprol 2020 Oct 27. Epub 2020 Oct 27.

Department of Dermatology, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, South Korea.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_718_19DOI Listing
October 2020

Bakuchicin attenuates atopic skin inflammation.

Biomed Pharmacother 2020 Sep 1;129:110466. Epub 2020 Jul 1.

Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Psoralea corylifolia is a medicinal herb that provides advantageous pharmacological effects against vitiligo and skin rash. Former studies have shown that bakuchicin, a furanocoumarin compound from the fruits of P. corylifolia, has therapeutic effects against inflammation, and infection. This study aimed to define the pharmacological effects of bakuchicin on inflammatory responses and lichenification, the major symptoms of atopic dermatitis (AD). To induce AD-like skin inflammation, we exposed the ears of female BALB/c mice to 2, 4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae (house dust mite) extract (DFE) for 4 weeks. Intragastric administration of bakuchicin attenuated the symptoms of AD-like skin inflammation, as evident by reductions in ear thickness, erythema, and keratosis. Bakuchicin also reversed increases in auricular epidermal and dermal layer thicknesses, and attenuated eosinophil and mast cell infiltration in AD-induced mice. It also suppressed T2 gene expression as well as that of pro-inflammatory cytokines and chemokines, such as interleukin (IL)-4, IL-13, IL-31, IL-1β, IL-6, CXCL-1, and CCL-17 in the ear tissue. The levels of total and DFE-specific immunoglobulin (Ig)E, and IgG2a in the mice sera were reduced by the bakuchicin. To investigate the effect of bakuchicin on keratinocytes, experiments were performed using HaCaT cells, the representative cell type used in skin disease studies. Tumor necrosis factor-α and interferon-γ were used to activate keratinocytes. Bakuchicin suppressed T2 gene expression and that of pro-inflammatory cytokines and chemokines; it also suppressed STAT-1 phosphorylation and the nuclear translocation of NF-κB in activated keratinocytes. These results suggest that bakuchicin attenuated AD symptoms, thus suggesting it as a potential therapeutic agent for the treatment of AD.
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http://dx.doi.org/10.1016/j.biopha.2020.110466DOI Listing
September 2020

Hispidulin alleviates imiquimod-induced psoriasis-like skin inflammation by inhibiting splenic Th1/Th17 cell population and keratinocyte activation.

Int Immunopharmacol 2020 Oct 14;87:106767. Epub 2020 Jul 14.

Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of epidermal keratinocytes accompanied by increased infiltration of immune cells. Previous studies have demonstrated that hispidulin (4',5,7-trihydroxy-6-methoxyflavone, HPD) has various pharmacological benefits such as anti-fungal, anti-inflammation, and anti-allergic effects. This study investigated the effectiveness of HPD to treat psoriasis using an imiquimod (IMQ)-induced mouse model and activated keratinocytes. IMQ was topically applied to the back skin of mice for six consecutive days, and the mice were orally administered HPD. Based on the histological observation and immunological analysis, oral administration of HPD suppressed psoriatic characteristics including skin thickness, psoriasis area severity index, transepidermal water loss, and neutrophil infiltration. HPD alleviated pathologically increased levels of immunoglobulin G2a, myeloperoxidase, and tumor necrosis factor-α. Splenic Th1 and Th17 cell populations were also reduced by HPD in the murine model. In addition, in activated keratinocytes, HPD inhibited gene expression of Th1- and Th17-associated cytokines and chemokines, and phosphorylation of mitogen-activated protein kinases and nuclear factor-κB. In summary, HPD alleviates psoriasis skin inflammation in vivo and in vitro. Therefore, we suggest that HPD would be a potent therapeutic candidate for the treatment of psoriasis.
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http://dx.doi.org/10.1016/j.intimp.2020.106767DOI Listing
October 2020

Clinical usefulness of thermography as a non-invasive screening test for differential diagnosis of vascular malformations.

Skin Res Technol 2020 09 20;26(5):759-761. Epub 2020 Mar 20.

Department of Dermatology, School of Medicine, Kyungpook National University Hospital, Kyungpook National University, Daegu, South Korea.

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http://dx.doi.org/10.1111/srt.12846DOI Listing
September 2020

SG-SP1 Suppresses Mast Cell-Mediated Allergic Inflammation via Inhibition of FcεRI Signaling.

Front Immunol 2020 28;11:50. Epub 2020 Jan 28.

CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea.

As the number of allergic disease increases, studies to identify new treatments take on new urgency. Epigallocatechin gallate (EGCG), a major component of green tea, has been shown to possess a wide range of pharmacological properties, including anti-inflammation and anti-viral infection. In previous study, gallic acid (GA), a part of EGCG, has shown anti-allergic inflammatory effect. To improve on preliminary evidence that GA has allergy mitigating effect, we designed SG-SP1 based on GA, and aimed to assess the effects of SG-SP1 on mast cell-mediated allergic inflammation using various animal and models. For experiments, various types of IgE-stimulated mast cells (RBL-2H3: mast cell-like basophilic leukemia cells, and primary cultured peritoneal and bone marrow-derived mast cells) were used to determine the role of SG-SP1 (0.1-1 nM). Immunoglobulin (Ig) E-induced passive cutaneous anaphylaxis and ovalbumin-induced systemic anaphylaxis, standard animal models for immediate-type hypersensitivity were also used. For , SG-SP1 reduced degranulation of mast cells by down-regulating intracellular calcium levels in a concentration-dependent manner. SG-SP1 decreased expression and secretion of inflammatory cytokines in activated mast cells. This suppressive effect was associated with inhibition of the phosphorylation of Lyn, Syk and Akt, and the nuclear translocation of nuclear factor-κB. Due to the strong inhibitory effect of SG-SP1 on Lyn, the known upstream signaling to FcεRI-dependent pathway, we confirmed the direct binding of SG-SP1 to FcεRI, a high affinity IgE receptor by surface plasmon resonance experiment. Oral administration of SG-SP1 hindered allergic symptoms of both anaphylaxis models evidenced by reduction of hypothermia, serum IgE, ear thickness, and tissue pigmentation. This inhibition was mediated by the reductions in serum histamine and interleukin-4. We determined that SG-SP1 directly interacts with FcεRI and propose SG-SP1 as a therapeutic candidate for mast cell-mediated allergic inflammatory disorders inhibition of FcεRI signaling.
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http://dx.doi.org/10.3389/fimmu.2020.00050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998798PMC
February 2021

Increased Expression of Interleukin-12 in Lesional Skin of Atopic Dermatitis Patients with Psoriasiform Features on Histopathology: An Immunohistochemical Study.

Ann Dermatol 2020 Feb 27;32(1):31-37. Epub 2019 Dec 27.

Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.

Background: Based on clinical and genetic differences, atopic dermatitis (AD) and psoriasis have been classified in two different diseases, but recently, some authors regarded them as in one spectrum. The histological similarities including epidermal hyperplasia between chronic stages of AD and psoriasis supports the presence of two diseases in one spectrum.

Objective: We investigated clinical and immunohistopathological characteristics of adult Korean patients with AD showing psoriasiform chronic dermatitis on histopathology.

Methods: In total, 59 Korean patients with chronic AD were enrolled. Clinical, laboratory, and histopathological features were compared between AD patients with psoriasiform features and those with non-psoriasiform chronic dermatitis features on histology. In addition, immunohistopathological characteristics were analyzed using antibodies for key regulatory and effector cytokines in psoriasis.

Results: Fifteen patients (25.4%) showed a more "psoriasiform" histological appearance. The lesions in patients with psoriasiform features often showed clearer boundaries and noticeable scaling. The interleukin (IL)-23 expression in the psoriasiform chronic dermatitis group was not different from that in the psoriasis group, but the IL-17 expression was less than that in the psoriasis group. In the case of IL-12, multiple dermal inflammatory cells with dendrites were stained in the psoriasiform chronic dermatitis group compared with the 2 other non-psoriasiform subgroups.

Conclusion: The results suggest that IL-12 secreted from dermal inflammatory cells might be one of the important factors associated with the formation of psoriasiform features in chronic AD. However, further studies are required to better define the specific role of IL-12.
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http://dx.doi.org/10.5021/ad.2020.32.1.31DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992638PMC
February 2020

Polyozellin alleviates atopic dermatitis-like inflammatory and pruritic responses in activated keratinocytes and mast cells.

Biomed Pharmacother 2020 Feb 30;122:109743. Epub 2019 Dec 30.

Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Polyozellus multiplex is an edible mushroom that offers beneficial pharmacological effects against intestinal inflammation and cancer. Previous studies have demonstrated that polyozellin, a major component of P. multiplex, has therapeutic activities against inflammation, cancer, and oxidative stress-related disorders. This study aimed to determine the pharmacological effects of polyozellin on inflammatory and pruritic responses, the major symptoms of atopic dermatitis (AD), and to define its underlying mechanism of action. Our results showed that polyozellin inhibited the expression of inflammatory cytokines and chemokines through blockade of signal transducer and activator of transcription 1 and nuclear factor-κB in activated keratinocytes, the major cells involved in AD progression. Based on the histological and immunological analyses, oral treatment with polyozellin attenuated the Dermatophagoides farinae extract (DFE)/2,4-dinitrochlorobenzene (DNCB)-induced atopic inflammatory symptoms in the skin. Pruritus is an unpleasant sensation for AD patients that causes scratching behavior and ultimately exacerbates the severity of AD. To find a possible explanation for the anti-pruritic effects of polyozellin, we investigated its effects on mast cells and mast cell-derived histamines. Oral treatment with polyozellin reduced the DFE/DNCB-induced tissue infiltration of mast cells, the serum histamine levels, and the histaminergic scratching behaviors. Additionally, polyozellin decreased the immunoglobulin E-stimulated degranulation of mast cells. Taken together, the findings of this study provide us with novel insights into the potential pharmacological targets of polyozellin for treating AD by inhibiting the inflammatory and pruritic responses.
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http://dx.doi.org/10.1016/j.biopha.2019.109743DOI Listing
February 2020

Prunus serrulata var. spontanea inhibits mast cell activation and mast cell-mediated anaphylaxis.

J Ethnopharmacol 2020 Mar 13;250:112484. Epub 2019 Dec 13.

Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: A promising approach to treat a variety of diseases are considered as complementary and alternative herbal medicines. Prunus serrulata var. spontanea L. (Rosaceae) is used as herbal medicine to treat allergic diseases according to the Donguibogam, a tradition medical book of the Joseon Dynasty in Korea.

Aim Of The Study: We prepared the aqueous extract of the bark of P. serrulata (AEBPS) and aimed to investigate the effects in mouse anaphylaxis models and various types of mast cells, including RBL-2H3, primary cultured peritoneal and bone marrow-derived mast cells.

Materials And Methods: We used ovalbumin (OVA)-induced active systemic anaphylaxis (ASA) and immunoglobulin (Ig) E-mediated passive cutaneous anaphylaxis (PCA) models, in vivo. The control drug dexamethasone (10 mg/kg) was used to compare the effectiveness of AEBPS (1-100 mg/kg). In vitro, IgE-stimulated mast cells were used to confirm the role of AEBPS (1-100 μg/mL). For statistical analyses, p values less than 0.05 were considered to be significant.

Results: In ASA model, oral administration of AEBPS suppressed the hypothermia and increased level of serum histamine in a dose-dependent manner. AEBPS attenuated the serum IgE, OVA-specific IgE, and interleukin (IL)-4. Oral administration of AEBPS also blocked mast cell-dependent PCA. AEBPS suppressed degranulation of mast cells by reducing intracellular calcium level in mast cells. AEBPS inhibited tumor necrosis factor-α and IL-4 expression and secretion in a concentration-dependent manner through the reduction of nuclear factor-κB.

Conclusions: On the basis of these findings, AEBPS could serve as a potential therapeutic target for the management of mast cell-mediated allergic inflammation and as a regulator of mast cell activation.
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http://dx.doi.org/10.1016/j.jep.2019.112484DOI Listing
March 2020

2019 Consensus Korean Diagnostic Guidelines to Define Severity Classification and Treatment Refractoriness for Atopic Dermatitis: Objective and Subjective Assessment of Severity.

Ann Dermatol 2019 Dec 31;31(6):654-661. Epub 2019 Oct 31.

Department of Dermatology, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.

Background: Systemic immunomodulatory treatment is actively recommended in the treatment for moderate to severe atopic dermatitis (AD) patients. However, consensus criteria for the classification of AD severity or treatment refractoriness have not been established yet.

Objective: To establish consensus criteria on the definition of severity classification and treatment refractoriness of AD to provide a basis for proper treatment strategy.

Methods: The Korean Atopic Dermatitis Association (KADA) comprised a task force team to establish a definition of moderate to severe AD. A draft of definition of moderate to severe AD was made on the basis of evidence. The recommendation was confirmed by KADA members through a web-based survey.

Results: KADA approved that AD with 16≤eczema area and severity index (EASI)<23 should be basically defined as moderate AD whereas AD with EASI score ≥23 should be considered as severe AD. They agreed that it would be reasonable to raise the severity level if patient's daytime or nighttime pruritus numerical rating scale is equal to or higher than 7 (≥7) or dermatology life quality index score exceeds 10. AD patients who do not reach EASI 50 after appropriate treatment for three months should be considered as a non-responder. Patients with recurrence (EASI ≥16) within three months after cessation of treatment should be considered as a recurrent AD.

Conclusion: KADA built a consensus of definition of moderate and severe AD and treatment-refractoriness. These guidelines are expected to help physicians determine proper treatment options in need.
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http://dx.doi.org/10.5021/ad.2019.31.6.654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992600PMC
December 2019

Effect of a sphingolipid-mimetic compound on the promotion of hair growth: A randomized, double-blind, placebo-controlled clinical trial.

J Cosmet Dermatol 2020 Jul 19;19(7):1715-1722. Epub 2019 Nov 19.

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

Background: Pattern hair loss is a very common skin disorder, but more therapeutic modalities for hair growth are still required.

Objective: We investigated the effect of a newly synthesized sphingolipid-mimetic compound (pseudo-ceramide: bis-oleamide isopropyl alcohol [BOI]) on the promotion of hair growth for patients with mild pattern hair loss.

Methods: A total of 58 patients with mild pattern hair loss participated in this clinical trial. A randomized, double-blind, placebo-controlled clinical trial was conducted for 6 months. Participants in the experimental group applied 1% BOI lotion (ceramide HS) on the whole scalp once a day for 6 months. Participants in the control group applied simulacrum using the same protocol. We evaluated daily hair loss, hair density, hair thickness, and hair length at intervals of 3 months; patient satisfaction and adverse events were evaluated at 6 months.

Results: At 6 months in the experimental group, daily hair loss at baseline (52.52 ± 33.98) decreased to 40.41 ± 24.78, vertex hair density at baseline (131.07 ± 43.73) increased to 156.00 ± 39.59, frontal hair density at baseline (104.21 ± 30.72) increased to 124.10 ± 28.28, thickness of vertex hair at baseline (0.067 ± 0.012 cm) increased to 0.075 ± 0.014 cm, thickness of frontal hair at baseline (0.070 ± 0.009 cm) increased to 0.076 ± 0.012 cm, and hair growth rate was 16.17 ± 1.89 mm/month.

Conclusion: Ceramide HS may be a new candidate for the treatment of pattern hair loss.
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http://dx.doi.org/10.1111/jocd.13220DOI Listing
July 2020

Bilobed Flap with a Plication Suture for Reconstruction of an Infraorbital Defect.

Ann Dermatol 2019 Aug 1;31(Suppl):S39-S40. Epub 2019 Jul 1.

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2019.31.S.S39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7997071PMC
August 2019

Validity and reliability of itch assessment scales for chronic pruritus in adults: A prospective multicenter study.

J Am Acad Dermatol 2020 Jan 27;82(1):80-86. Epub 2019 Jun 27.

Chonnam National University Medical School, Gwangju, Republic of Korea. Electronic address:

Background: Several tools can provide a reliable and accurate evaluation of pruritus, including the visual analog scale (VAS), numeric rating scale (NRS), verbal rating scale (VRS), and multidimensional questionnaires such as the Itch Severity Scale (ISS). However, no single method is considered a gold standard.

Objective: We evaluated the validity and reliability of VAS, NRS, VRS, and ISS and their correlation with a pruritus-specific quality of life instrument, ItchyQoL.

Methods: A total of 419 patients (215 men and 204 women) with chronic pruritus (mean age, 46.58 years) recorded their pruritus intensity on VAS, NRS, VRS, and ISS. Retest reliability was analyzed in a second assessment 3 hours after the initial assessment. All participants answered ItchyQoL.

Results: A strong correlation between VAS, NRS, and VRS was found. ISS showed a low intercorrelation validity with these tools. However, ISS was more strongly correlated with ItchyQoL. The retest reliability scores were similar for VAS, NRS, and VRS but lower than the scores obtained for ISS.

Limitations: Limitations include patient heterogeneity and recall bias.

Conclusion: The assessment of pruritus is challenging because of the subjective symptoms and the multifactorial nature. Therefore, more studies are needed to determine the best strategy to assess itch intensity.
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http://dx.doi.org/10.1016/j.jaad.2019.06.043DOI Listing
January 2020

Current Status of Patient Education in the Management of Atopic Dermatitis in Korea.

Yonsei Med J 2019 Jul;60(7):694-699

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Patient education is important for successful management of atopic dermatitis; however, due to limited time and resources, patient education remains insufficient. This study aimed to investigate the current state of education provided by Korean dermatologists, pediatric allergists, and allergists to patients with atopic dermatitis. A questionnaire survey consisting of items regarding educational programs for patients with atopic dermatitis was conducted via e-mail. In total, 153 participants responded to the questionnaires, and 26.8% indicated that they have had separate educational programs. The workforce involved in the educational program included nurses, residents or fellows, dieticians, pharmacists, and clinical psychologists. Most education protocols addressed the characteristics and natural course of atopic dermatitis and environmental management. Overall, 96.7% of the participants replied that an additional charge is needed for education; moreover, additional assistance from an academic society or association, in the form of medical staff, organized data, and advertisement, is required to develop and provide a well-structured educational program. A standardized education protocol will effectively provide appropriate education for patients with atopic dermatitis. Arrangement of education fees, covered by the National Health Insurance Service, will lead to the establishment of a structured educational program and participation of an additional medical workforce.
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http://dx.doi.org/10.3349/ymj.2019.60.7.694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6597467PMC
July 2019

Inhibitory effect of ethanol extract of Ampelopsis brevipedunculata rhizomes on atopic dermatitis-like skin inflammation.

J Ethnopharmacol 2019 Jun 4;238:111850. Epub 2019 Apr 4.

Cell and Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Extracts from various parts of Ampelopsis brevipedunculata has been used as anti-inflammatory agents in Asian folk medicine.

Aim Of The Study: To demonstrate the medicinal effect of the A. brevipedunculata in skin inflammation, specifically atopic dermatitis (AD).

Materials And Methods: The effect of ethanol extract of A. brevipedunculata rhizomes (ABE) on AD was examined using an AD-like skin inflammation model induced by repeated exposure to house dust mite (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB). The mechanism study was performed using tumor necrosis factor (TNF)-α and interferon (IFN)-γ-activated human keratinocytes (HaCaT). Serum histamine and immunoglobulin levels were quantified using enzymatic kits, while the gene expression of cytokines and chemokines was analyzed using quantitative real time polymerase chain reaction. The expression of signaling molecules was detected using Western blot.

Results: Oral administration of ABE alleviated DFE/DNCB-induced ear thickening and clinical symptoms, as well as immune cell infiltration (mast cells and eosinophils) into the dermal layer. Serum Immunoglobulin (Ig) E, DFE-specific IgE, IgG2a, and histamine levels were decreased after the administration of ABE. ABE also inhibited CD4IFN-γ and CD4IL-4 lymphocyte polarization in lymph nodes and expression of TNF-α, IFN-γ, IL-4, IL-13, and IL-31 in the ear tissue. In TNF-α/INF-γ-stimulated keratinocytes, ABE inhibited the gene expression of TNF-α, IL-6, IL-1β, and CCL17. In addition, ABE decreased the nuclear localization of signal transducer and activator of transcription 1 and nuclear factor-κB, and the phosphorylation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase.

Conclusion: Collectively, our data demonstrate the pharmacological role and signaling mechanism of ABE in the regulation of skin allergic inflammation, which supports our suggestion that ABE could be developed as a potential therapeutic agent for the treatment of AD.
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http://dx.doi.org/10.1016/j.jep.2019.111850DOI Listing
June 2019

Clinical Investigation on Preadolescent Acne.

Ann Dermatol 2019 Apr 28;31(2):249-251. Epub 2019 Feb 28.

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2019.31.2.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992672PMC
April 2019

A Case of Perinevoid Alopecia on the Scalp.

Ann Dermatol 2019 Apr 28;31(2):244-246. Epub 2019 Feb 28.

Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2019.31.2.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992677PMC
April 2019

Long-Term Prognosis of Alopecia Areata in Children and Adolescents.

Ann Dermatol 2019 Apr 28;31(2):231-234. Epub 2019 Feb 28.

Department of Dermatology, School of Medicine, Kyungpook National University, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2019.31.2.231DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992685PMC
April 2019

Necrolytic migratory erythema.

CMAJ 2019 03;191(10):E286

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Republic of Korea

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http://dx.doi.org/10.1503/cmaj.180913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411476PMC
March 2019

Anti-Inflammatory and Antioxidative Effects of Alpha Lipoic Acid on Cultured Human Sebocytes.

Ann Dermatol 2019 Feb 2;31(1):84-87. Epub 2019 Jan 2.

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2019.31.1.84DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992692PMC
February 2019

Huge Steatocystoma Multiplex with New Point Mutation in the Exon 1 of KRT 17 Gene.

Ann Dermatol 2018 Oct 28;30(5):633-635. Epub 2018 Aug 28.

Department of Dermatology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2018.30.5.633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7992486PMC
October 2018

Low But Continuous Occurrence of Infection in the Study on 198 Cases in South Korea from 1979 to 2016.

Ann Dermatol 2018 Aug 28;30(4):427-431. Epub 2018 Jun 28.

Institue of Medical Mycology, Catholic Skin Clinic, Daegu, Korea.

Background: has been isolated from South Korea since 1966. However, the incidence of infection is very low.

Objective: The aim of this study is to add massive data on to the literature and to provide useful information on clinical and mycological characteristics of .

Methods: We retrospectively analyzed data of 198 cases infected with from 1979 to 2016. The identification of was done with mycological examination using 15% KOH preparation and potato corn meal tween 80 agar culture media.

Results: The incidence of infection was very low in South Korea, showing a tendency to decrease. Out of 198 cases, men were 94 cases (47.5%) and women were 104 cases (52.5%). Mean age of all patients was 29.83 years old: 24.97 years old in men and 34.22 years old in women. infection occurred most frequently in September (16.7%) and August (16.2%). The most common clinical type of infection was tinea corporis (38.4%).

Conclusion: infection shows very low incidence but still remains around us until recent years. We should keep in mind the characteristics of .
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http://dx.doi.org/10.5021/ad.2018.30.4.427DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029965PMC
August 2018

Survey of disease awareness, treatment behavior and treatment satisfaction in patients with atopic dermatitis in Korea: A multicenter study.

J Dermatol 2018 Oct 18;45(10):1172-1180. Epub 2018 Jul 18.

Department of Dermatology, National Medical Center, Seoul, Korea.

In Korea, there is a high dependency on oriental medicine and folk remedies (Korean J Asthma Allergy Clin Immunol, 25, 2005, 110). In addition, inaccurate information available through the Internet is increasing (Korean J Dermatol, 44, 2006, 137). So, there is always a possibility that patients may have difficulty obtaining accurate information about atopic dermatitis (AD). The aim was to determine the awareness, treatment behavior and treatment satisfaction of patients with AD and their caregivers. In October 2017, patients diagnosed with AD at nine hospitals were enrolled in this study. A questionnaire was completed by each patient. A total of 371 subjects were surveyed. In response to the question asking about knowledge of AD, the correct answer rate was 55.4%. Bathing using soap, body scrub and moisturizer showed favorable outcomes. A total of 54.9% patients responded that they were reluctant to use steroid ointment. When asked about their previous treatment, 39.6% reported using oriental medicine and 26.5% had tried folk remedies. The hospital treatment satisfaction score was 6.6. Patients usually applied their knowledge in their daily lives. However, there was a lot of inaccurate knowledge. Therefore, it is important for patients to understand the characteristics of this disease and obtain correct information.
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http://dx.doi.org/10.1111/1346-8138.14540DOI Listing
October 2018

Esculetin from Fraxinus rhynchophylla attenuates atopic skin inflammation by inhibiting the expression of inflammatory cytokines.

Int Immunopharmacol 2018 Jun 12;59:209-216. Epub 2018 Apr 12.

Cell & Matrix Research Institute, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea. Electronic address:

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder afflicting from infancy to adults with itching, scratching, and lichenification. We aimed to investigate the effects of esculetin from Fraxinus rhynchophylla on atopic skin inflammation. For induction of atopic skin inflammation, we exposed the ears of female BALB/c mice to house dust mite (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) for 4 weeks. Oral administration of esculetin reduced the symptoms of DFE/DNCB-induced atopic skin inflammation, which were evaluated based on ear swelling and number of scratch bouts. The immunoglobulin (Ig) E, IgG2a, and histamine levels in serum were decreased and inflammatory cell infiltration in skin tissue was reduced by the esculetin. It suppressed production of Th1, Th2 and Th17-related cytokines such as tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-4, IL-13, IL-31 and IL-17 in the ear tissue. Furthermore, we investigated the effects of esculetin on activated keratinocytes, which are representative cells used for studying the pathogenesis of acute and chronic atopic skin inflammation. As results, esculetin suppressed gene expression of Th1, Th2 and Th17 cytokines and the activation of nuclear factor-κB and signal transducer and activator of transcription 1 in TNF-α/IFN-γ-stimulated keratinocytes. Taken together, these results imply that esculetin attenuated atopic skin inflammation, suggesting that esculetin could be a potential therapeutic candidate for the treatment of AD.
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http://dx.doi.org/10.1016/j.intimp.2018.04.005DOI Listing
June 2018

Tinea Faciei in a Mother and Daughter Caused by .

Ann Dermatol 2018 Apr 21;30(2):241-242. Epub 2018 Feb 21.

Institute of Medical Mycology, Catholic Skin Clinic, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2018.30.2.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839903PMC
April 2018

A Case of Phaeohyphomycosis on the Wrist: Identification of in Korea.

Ann Dermatol 2018 Apr 21;30(2):232-233. Epub 2018 Feb 21.

Institute of Medical Mycology, Catholic Skin Clinic, Daegu, Korea.

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http://dx.doi.org/10.5021/ad.2018.30.2.232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839899PMC
April 2018