Publications by authors named "Yong He"

1,548 Publications

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Systematic analysis of the CsmiR396-CsGRFs/CsGIFs module and the opposite role of CsGRF3 and CsGRF5 in regulating cell proliferation in cucumber.

Plant Sci 2022 Aug 3:111407. Epub 2022 Aug 3.

Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang Agriculture and Forestry University, Hangzhou 311300, Zhejiang, China; Key Laboratory of Quality and Safety Control for Subtropical Fruit and Vegetable, Ministry of Agriculture and Rural Affairs, Hangzhou 311300, Zhejiang, China. Electronic address:

Growth-regulating factors (GRFs) are plant-specific transcription factors, and their activities are regulated by miR396 and the GRF-GIF interaction. The miR396-GRFs/GIFs module determines organ size by regulating cell proliferation. However, it is largely unknown in cucumber. In this study, the CsmiR396-CsGRFs/CsGIFs module was investigated in cucumber. Five CsMIR396 loci (CsMIR396A-E), eight CsGRFs and two CsGIFs were identified. CsMIR396A-E was distributed within two clusters and coded three different mature CsmiR396, and all CsGRFs acted as the target of CsmiR396. Bioinformatic analyses showed that miR396s were classified into five types, while GRFs were classified into six groups in plants. The GRFs from group Ⅰ exhibited high diversity and harbored specific characteristics (truncated C-terminus or two WRC domains). qRT-PCR results showed that CsMIR396s (CsMIR396A, CsMIR396B and CsMIR396D) and mature CsmiR396 increased, whereas CsGRFs declined as leaf age increased. In contrast, CsMIR396E was highly expressed in young leaves and shoot tissue, and it was expressed in an age-independent pattern. Yeast two-hybrid assays showed that CsGRF3 strongly interacted with CsGIFs, while CsGRF5 weakly interacted with CsGIFs. Overexpression of CsGRF3 resulted in an enlarged organ size; in contrast, overexpression of CsGRF5, which belonged to group Ⅰ and harbored two WRC domains, resulted in a reduced organ size in Arabidopsis. Section analysis showed that cell proliferation was increased in CsGRF3OE plants, whereas it was decreased in CsGRF5OE plants. In summary, our results reveal the diversity of the CsmiR396-CsGRFs/CsGIFs module in cucumber, and that CsGRF3 and CsGRF5 play an opposite role in regulating cell proliferation.
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http://dx.doi.org/10.1016/j.plantsci.2022.111407DOI Listing
August 2022

Shape-Encoded Functional Hydrogel Pellets for Multiplexed Detection of Pathogenic Bacteria Using a Gas Pressure Sensor.

ACS Sens 2022 Aug 2. Epub 2022 Aug 2.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

Gas pressure is a promising signal readout mode in point-of-care testing for its merits such as rapidity, simplicity, affordability, and no need for sophisticated instrumentation. Herein, a gas pressure sensor for multiplexed detection of pathogenic bacteria was developed on a hydrogel platform. Spherical and square hydrogel pellets prepared by cross-linking of sodium alginate were functionalized with nisin and ConA for the capture of and O157:H7, respectively. By using the shape-encoded functional hydrogel pellets and aptamer-modified platinum-coated gold nanoparticles ([email protected]), a dual-molecule recognition mode was established for rapid and specific detection of the two pathogenic bacteria. [email protected] were applied as signal probes to efficiently catalyze the decomposition of HO for generating abundant O, which was converted into an amplified gas pressure signal. In two closed containers, the significant gas pressure signals were monitored with a portable pressure meter to quantitate the two pathogenic bacteria. The sensor was successfully applied to detect the pathogenic bacteria in various environmental, biological, and food samples. Thus, the proof-of-principle work paves a new avenue for multiplexed detection of pathogenic bacteria with shape-encoded hydrogel pellets combined with gas pressure signal readout.
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http://dx.doi.org/10.1021/acssensors.2c01186DOI Listing
August 2022

Automatic differentiation of human induced pluripotent stem cells toward synchronous neural networks on an arrayed monolayer of nanofiber membrane.

Acta Biomater 2022 Jul 28. Epub 2022 Jul 28.

PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France. Electronic address:

Automatic differentiation of human-induced pluripotent stem cells (hiPSCs) facilitates the generation of cortical neural networks and studies of brain functions. Here, we present a method of directed differentiation of hiPSCs with a substrate made of a honeycomb microframe and a monolayer of crosslinked gelatin nanofibers in the form of an array of nanofiber membranes. Neural precursor cells (NPCs) were firstly derived from hiPSCs and then placed on the nanofiber membranes for automatically controlled neural differentiation over a long period. Due to the strong modulation of the substrate stiffness and permeability, most cells were found in the center area of the honeycomb compartments, giving rise to regular and inter-connected cortical neural clusters. More importantly, the neural activities of the clusters were synchronized proving the reliability of the method. Our results showed that the self-organization, as well as the neural activities of differentiating neural cells, were more efficient in the nanofiber membrane compared to the types of the substrate such as glass and nanofiber-covered glass. In addition to the inherent advantages such as manpower saving and fewer risks of contamination and human error, automatic differentiation avoided undesired shaking which might have critical effects on the formation of synchronous neural clusters. STATEMENT OF SIGNIFICANCE: Synchronization of cortical neural activities is essential for information processing and human cognition. By automated differentiation of human induced pluripotent stem cells on arrayed monolayer of nanofiber membrane, synchronous neural clusters could be formed. Such an approach would allow creating a variety of neural networks with regular and interconnected clusters for systematic studies of human cortical functions.
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http://dx.doi.org/10.1016/j.actbio.2022.07.038DOI Listing
July 2022

Genotyping of cerebrospinal fluid in lung cancer patients with leptomeningeal metastasis.

Thorac Cancer 2022 Jul 27. Epub 2022 Jul 27.

Department of Respiratory Disease, Daping Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

Background: The prognosis of non-small-cell lung cancer (NSCLC) with leptomeningeal metastasis (LM) is poor. Detection of cell-free DNA (cfDNA) by next generation sequencing (NGS) in cerebrospinal fluid (CSF) may facilitate diagnosis of LM and identification of drug resistance mechanisms, yet its clinical use needs to be further verified.

Methods: We performed a retrospective cohort study to assess the genetic profiles of paired CSF and plasma samples in lung cancer patients with LM. Of 17 patients screened, a total of 14 patients with LM and paired NGS tests were enrolled.

Results: All patients harbor driver gene mutations, including 12 epidermal growth factor receptor (EGFR) activating mutations, 1 anaplastic lymphoma kinase (ALK) rearrangement, and 1 ROS-1 fusion. Genetic mutations were detected in CSF cfDNA from 92.9% patients (13/14), which was significantly higher than that from the plasma (9/14, 64.2%). The mutations were highly divergent between CSF and plasma cfDNA, with a concordance rate of 24.38% and 10 mutations shared by the two media. CSF cfDNA could also benefit the analysis of resistance mechanisms to targeted therapies. In five patients who experienced progression on 1st or 2nd generation EGFR-tyrosine kinase inhibitors (TKIs), RB1 mutation, and amplification of MET and EGFR were detected in CSF cfDNA only. In eight patients with LM progression on osimertinib resistance, EGFR amplification was detected in CSF cfDNA from four patients, whereas no CNVs were detected in the matched plasma samples.

Conclusions: In conclusion, CSF could be superior to plasma in providing a more comprehensive genetic landscape of LM to find out drug resistance mechanisms and guide subsequent treatments.
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http://dx.doi.org/10.1111/1759-7714.14592DOI Listing
July 2022

Distinct Temporal Pattern of the Prediction of Lumen Remodeling of Lower Extremity Vein Bypass Grafts by Initial Local Hemodynamics.

Ann Biomed Eng 2022 Jul 26. Epub 2022 Jul 26.

Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, University of Florida, PO Box 100128, Gainesville, FL, 32610-0286, USA.

We predicted human lower extremity vein bypass graft remodeling by hemodynamics. Computed tomography and duplex ultrasound scans of 55 patients were performed at 1 week and 1, 6, and 12 months post-implantation to obtain wall shear stress (WSS) and oscillatory shear index (OSI) at 1-mm intervals via computational fluid dynamics simulations. Graft remodeling was quantified by computed tomography-measured lumen diameter changes in the early (1 week-1 month), intermediate (1-6 months), and late (6-12 months) periods. Linear mixed-effect models were constructed to examine the overall relationship between remodeling and initial hemodynamics using the average data of all cross sections within the same graft. A significant association of graft remodeling with WSS (p < 0.001) and time (p = 0.001) was found; however, the effect size decreased with time (every 2.7 dyne/cm increase of WSS was associated with a 0.39, 0.35, 0.002 mm diameter increase in the three periods, respectively). The association of remodeling with OSI was significant only in the intermediate period (every 0.1 increase of OSI was associated with a 0.25 mm lumen diameter decrease, p = 0.004). Therefore, the association of graft lumen remodeling with local hemodynamics has a distinct temporal pattern; WSS and OSI are predictive of remodeling only in certain postoperative periods.
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http://dx.doi.org/10.1007/s10439-022-03019-7DOI Listing
July 2022

Activation of VIPR1 suppresses hepatocellular carcinoma progression by regulating arginine and pyrimidine metabolism.

Int J Biol Sci 2022 4;18(11):4341-4356. Epub 2022 Jul 4.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Vasoactive intestinal polypeptide type-I receptor (VIPR1) overexpression has been reported in numerous types of malignancies and utilized to develop novel target therapeutics and radiolabeled VIP analogue-based tumor imaging technology, but its role in liver carcinogenesis has not been explored. In the current study, we investigated the role of the VIP/VIPR1 signaling in controlling hepatocellular carcinoma (HCC) progression. By analyzing clinical samples, we found the expression level of VIPR1 was downregulated in human HCC tissues, which was correlated with advanced clinical stages, tumor growth, recurrence, and poor outcomes of HCC clinically. and in studies revealed that activation of VIPR1 by VIP markedly inhibited HCC growth and metastasis. Intriguingly, transcriptome sequencing analyses revealed that activation of VIPR1 by VIP regulated arginine biosynthesis. Mechanistical studies in cultured HCC cells demonstrated that VIP treatment partially restored the expression of arginine anabolic key enzyme argininosuccinate synthase (ASS1), and to some extent, inhibited pyrimidine synthetic pathway by downregulating the activation of CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). VIP treatment upregulated ASS1 and subsequently suppressed CAD phosphorylation in an mTOR/p70S6K signaling dependent manner. Clinically, we found human HCC samples were associated with downregulation of ASS1 but upregulation of CAD phosphorylation, and that VIPR1 levels positively correlated with ASS1 levels and serum levels of urea, the end product of the urea cycle and arginine metabolism in HCC. Loss of VIPR1 expression in HCC facilitates CAD phosphorylation and tumor progression, and restoration of VIPR1 and treatment with the VIPR1 agonist may be a promising approach for HCC treatment.
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http://dx.doi.org/10.7150/ijbs.71134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9295067PMC
July 2022

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure.

J Clin Invest 2022 Jul;132(14)

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, USA.

Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH) pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH remains obscure. This translational study aims to describe the patterns of intrahepatic neutrophil infiltration and its involvement in SAH pathogenesis. Immunohistochemistry analyses of explanted livers identified two SAH phenotypes despite a similar clinical presentation, one with high intrahepatic neutrophils (Neuhi), but low levels of CD8+ T cells, and vice versa. RNA-Seq analyses demonstrated that neutrophil cytosolic factor 1 (NCF1), a key factor in controlling neutrophilic ROS production, was upregulated and correlated with hepatic inflammation and disease progression. To study specifically the mechanisms related to Neuhi in AH patients and liver injury, we used the mouse model of chronic-plus-binge ethanol feeding and found that myeloid-specific deletion of the Ncf1 gene abolished ethanol-induced hepatic inflammation and steatosis. RNA-Seq analysis and the data from experimental models revealed that neutrophilic NCF1-dependent ROS promoted alcoholic hepatitis (AH) by inhibiting AMP-activated protein kinase (a key regulator of lipid metabolism) and microRNA-223 (a key antiinflammatory and antifibrotic microRNA). In conclusion, two distinct histopathological phenotypes based on liver immune phenotyping are observed in SAH patients, suggesting a separate mechanism driving liver injury and/or failure in these patients.
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http://dx.doi.org/10.1172/JCI157780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282929PMC
July 2022

A de novo assembled high-quality chromosome-scale Trifolium pratense genome and fine-scale phylogenetic analysis.

BMC Plant Biol 2022 Jul 11;22(1):332. Epub 2022 Jul 11.

College of Grassland Science, Qingdao Agricultural University, Qingdao, 266109, China.

Background: Red clover (Trifolium pratense L.) is a diploid perennial temperate legume with 14 chromosomes (2n = 14) native to Europe and West Asia, with high nutritional and economic value. It is a very important forage grass and is widely grown in marine climates, such as the United States and Sweden. Genetic research and molecular breeding are limited by the lack of high-quality reference genomes. In this study, we used Illumina, PacBio HiFi, and Hi-C to obtain a high-quality chromosome-scale red clover genome and used genome annotation results to analyze evolutionary relationships among related species.

Results: The red clover genome obtained by PacBio HiFi assembly sequencing was 423 M. The assembly quality was the highest among legume genome assemblies published to date. The contig N50 was 13 Mb, scaffold N50 was 55 Mb, and BUSCO completeness was 97.9%, accounting for 92.8% of the predicted genome. Genome annotation revealed 44,588 gene models with high confidence and 52.81% repetitive elements in red clover genome. Based on a comparison of genome annotation results, red clover was closely related to Trifolium medium and distantly related to Glycine max, Vigna radiata, Medicago truncatula, and Cicer arietinum among legumes. Analyses of gene family expansions and contractions and forward gene selection revealed gene families and genes related to environmental stress resistance and energy metabolism.

Conclusions: We report a high-quality de novo genome assembly for the red clover at the chromosome level, with a substantial improvement in assembly quality over those of previously published red clover genomes. These annotated gene models can provide an important resource for molecular genetic breeding and legume evolution studies. Furthermore, we analyzed the evolutionary relationships among red clover and closely related species, providing a basis for evolutionary studies of clover leaf and legumes, genomics analyses of forage grass, the improvement of agronomic traits.
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http://dx.doi.org/10.1186/s12870-022-03707-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277957PMC
July 2022

Neurological Symptoms and Their Associations With Inflammatory Biomarkers in the Chronic Phase Following Traumatic Brain Injuries.

Front Psychiatry 2022 24;13:895852. Epub 2022 Jun 24.

Department of Forensic Psychiatry, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, China.

Background: The underlying biological mechanisms for neurological symptoms following a traumatic brain injury (TBI) remain poorly understood. This study investigated the associations between serum inflammatory biomarkers and neurological symptoms in the chronic phase following moderate to severe TBI.

Methods: The serum interleukin [IL]-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, and the tumor necrosis factor [TNF]-α in 72 TBI patients 6 months to 2 years post injury were measured. Neurological symptoms including depression, chronic headache, sleep disturbance, irritability, anxiety, and global neurological disability was assessed. The associations between the biomarkers and the neurological symptoms were assessed using correlation and regression analysis.

Results: It was found that the most common post-injury symptom was sleep disturbance (84.7%), followed by chronic headaches (59.7%), irritability (55.6%), and depression (54.2%). TNF-α was a protective factor for chronic headache (OR = 0.473, 95% CI = 0.235-0.952). IL-6 was positively associated with sleep disturbance (r = 0.274, = 0.021), while IL-5 and IL-12p70 were negatively associated with the degree of global neurological disability (r = -0.325, = 0.006; r = -0.319, = 0.007).

Conclusion: This study provides preliminary evidence for the association between chronic inflammation with neurological symptoms following a TBI, which suggests that anti-inflammatory could be a potential target for post-TBI neurological rehabilitation. Further research with larger sample sizes and more related biomarkers are still needed, however, to elucidate the inflammatory mechanisms for this association.
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http://dx.doi.org/10.3389/fpsyt.2022.895852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263586PMC
June 2022

sGRP78 enhances selective autophagy of monomeric TLR4 to regulate myeloid cell death.

Cell Death Dis 2022 Jul 7;13(7):587. Epub 2022 Jul 7.

Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China.

Soluble glucose regulated protein 78 (sGRP78) has long been suggested as a mediator resolution of inflammation. We previously reported that sGRP78 induced the rapid endocytosis of TLR4 with defective TLR4 signaling. To elucidate the underlying mechanisms, in this study, we investigated how sGRP78 influenced the behavior and trafficking of TLR4 in myeloid cells. It was found that sGRP78 promoted LPS endocytosis with monomeric TLR4. This internalized monomeric TLR4 formed complexes with p62-LC3, and was degraded in autolysosomes. Furthermore, the sGRP78-enhanced autophagy-dependent TLR4 degradation caused apoptosis and ferroptosis in myeloid cells, contributing to the sGRP78-mediated resolution of inflammation. These reports establish innovative mechanisms for endotoxin clearance and immune regulation by TLR4 degradation, linking innate immunity with multiple ancient processes, including autophagy, apoptosis, and ferroptosis, together through a shared resolution-associated molecular pattern (RAMP)-sGRP78.
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http://dx.doi.org/10.1038/s41419-022-05048-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9262968PMC
July 2022

Scale-out production of extracellular vesicles derived from natural killer cells via mechanical stimulation in a seesaw-motion bioreactor for cancer therapy.

Biofabrication 2022 08 5;14(4). Epub 2022 Aug 5.

Department of Respiratory and Critical Care Medicine, Provincial Clinical Research Center for Respiratory Diseases, West China Hospital, Sichuan University, Chengdu 610065, People's Republic of China.

Extracellular vesicles (EVs) derived from immune cells have shown great anti-cancer therapeutic potential. However, inefficiency in EV generation has considerably impeded the development of EV-based basic research and clinical translation. Here, we developed a seesaw-motion bioreactor (SMB) system by leveraging mechanical stimuli such as shear stress and turbulence for generating EVs with high quality and quantity from natural killer (NK) cells. Compared to EV production in traditional static culture (229 ± 74 particles per cell per day), SMB produced NK-92MI-derived EVs at a higher rate of 438 ± 50 particles per cell per day and yielded a total number of 2 × 10EVs over two weeks via continuous dynamic fluidic culture. In addition, the EVs generated from NK-92MI cells in SMB shared a similar morphology, size distribution, and protein profile to EVs generated from traditional static culture. Most importantly, the NK-92MI-derived EVs in SMB were functionally active in killing melanoma and liver cancer cells in both 2D and 3D culture conditions, as well as in suppressing melanoma growth. We believe that SMB is an attractive approach to producing EVs with high quality and quantity; it can additionally enhance EV production from NK92-MI cells and promote both the basic and translational research of EVs.
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http://dx.doi.org/10.1088/1758-5090/ac7eebDOI Listing
August 2022

Malignancy risk stratification for solitary pulmonary nodule: A clinical practice guideline.

J Evid Based Med 2022 Jun 1;15(2):142-151. Epub 2022 Jul 1.

Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.

Clinical Question: The detection rate of the solitary pulmonary nodule (SPN) is increasing with the popularization of CT scanning. Malignancy risk stratification for SPN is a major clinical difficulty.

Current Practice: There have been several guidelines for SPN assessment. Inconsistency of these guidelines makes the clinical application difficult and confusing.

Recommendations: In this Rapid Recommendation, solid and subsolid SPNs are recommended to be evaluated respectively. Six factors, namely the combination of age with sex, smoking history, history of malignancy, family history of malignancy, and nodule size, are recommended for malignancy risk stratification for both kinds of SPNs; the border of nodules (spiculation and lobulation) is recommended for evaluating solid SPNs and the density of nodules (pure or mixed ground-glass nodule) is recommended for subsolid nodules. Among them, smoking history and radiologic features (nodule diameter, border, and density) are of relatively higher importance. A scoring system was proposed to assist malignancy risk stratification of SPNs, with a total score ranging from six points to 15 points (if solid) or 17 points (if subsolid). For each SPN, regardless of solid or subsolid in nature, a total score of ≤ 7 points suggested a low risk of being malignant, while 7 to 9 points suggested medium risk, and ≥ 9 points suggested high risk.

How This Guideline Was Created: This rapid recommendation was developed using the MAGIC (Making GRADE the Irresistible Choice) methodological framework. First, a clinical subcommittee identified the topic of recommendation and requested evidence. Then, an independent evidence synthesis subcommittee performed a comprehensive literature review and evaluated the evidence. Finally, based on findings from the systematic review and use of real-world data, the clinical subcommittee formulated recommendations, including the scoring system, through a consensus procedure.

The Evidence: A total of 13857 patients with SPNs were included in the meta-analysis and the association between 12 candidate factors and the risk of SPNs being malignant was studied. Eventually, seven factors were recommended for SPNs evaluation, and a scoring system was proposed.

Understanding The Recommendation: The parameters included are objective. Therefore, this recommendation is feasible in clinical practice. However, there are several uncertainties, such as a lack of further verification. It might be misclassified by the scoring system. Clinicians could choose the most suitable scheme according to the recommendation, along with their own experience in specific situations.
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http://dx.doi.org/10.1111/jebm.12476DOI Listing
June 2022

Mixed-Delay-Based Augmented Functional for Sampled-Data Synchronization of Delayed Neural Networks With Communication Delay.

IEEE Trans Neural Netw Learn Syst 2022 Jun 30;PP. Epub 2022 Jun 30.

The synchronization control for delayed neural networks (DNNs) via a sampled-data controller considering communication delay is studied by input delay approach. Although few scholars have put forward the coexistence of transmission delay and communication delay in this problem, no report has clarified the interaction between transmission delay and communication delay. Also, the time-squared terms are underutilized. Thus, a novel augmented Lyapunov functional, which consists of a mixed-delay-based augmented part and a time-squared two-sided looped part, is proposed to fill this gap. In the mixed-delay-based augmented part, not only the information of transmission delay and communication delay themselves, but also the interaction between those two delays is considered. Time-dependent quadratic terms as well as the sampling integral states are introduced in the two-sided looped part, so that more characteristic information of the sampling pattern is encompassed and the relationship of the states at the sampling instant is enhanced. Then, this novel augmented functional is applied to the synchronization control of DNNs. A less conservative synchronization criterion is obtained in the form of linear matrix inequalities. A numerical example illustrates the validity and superiority of the presented synchronization criterion.
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http://dx.doi.org/10.1109/TNNLS.2022.3185617DOI Listing
June 2022

Early outcomes of Sun's procedure in elderly patients with acute aortic dissection: a single-center retrospective study.

J Int Med Res 2022 Jun;50(6):3000605221109377

Department of Cardiovascular Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Yanta West Road No. 277, Xi'an 710061, China.

Objective: The effect of patient age on the outcome of Sun's procedure for acute type A aortic dissection (ATAAD) remains controversial. We retrospectively investigated the early outcomes of Sun's procedure in elderly patients with ATAAD in our single center.

Methods: This study involved 106 patients who underwent Sun's procedure. The patients were divided into the elderly group (≥70 years, n = 17) and younger group (<70 years). Baseline, intraoperative, and postoperative data were compared between the groups.

Results: The mean age in the elderly and younger groups was 75.7 and 50.7 years, respectively. The type of aortic root operations were not significantly different between the groups. Concomitant surgeries were more frequently performed in the elderly group, but without statistical significance. All intraoperative cardiopulmonary bypass variables as well as the in-hospital and 30-day mortality rates were similar between the groups. The incidences of most postoperative complications were also similar except for a higher incidence of sepsis in the elderly group.

Conclusions: Emergency performance of Sun's procedure for patients with ATAAD characterized by dissection and/or entry tear in the aortic arch should not be denied on the basis of advanced age alone. Comparable early in-hospital outcomes can be achieved in elderly patients.
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http://dx.doi.org/10.1177/03000605221109377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9251999PMC
June 2022

Type-Dependent Average Dwell Time Method and Its Application to Delayed Neural Networks With Large Delays.

IEEE Trans Neural Netw Learn Syst 2022 Jun 29;PP. Epub 2022 Jun 29.

This article investigates the stability of delayed neural networks with large delays. Unlike previous studies, the original large delay is separated into several parts. Then, the delayed neural network is viewed as the switched system with one stable and multiple unstable subsystems. To effectively guarantee the stability of the considered system, the type-dependent average dwell time (ADT) is proposed to handle switches between any two sequences. Besides, multiple Lyapunov functions (MLFs) are employed to establish stability conditions. Adding more delayed state vectors increases the allowable maximum delay bound (AMDB), reducing the conservatism of stability criteria. A general form of the global exponential stability condition is put forward. Finally, a numerical example illustrates the effectiveness, and superiority of our method over the existing one.
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http://dx.doi.org/10.1109/TNNLS.2022.3184712DOI Listing
June 2022

Integrated Multi-Omics Analysis Model to Identify Biomarkers Associated With Prognosis of Breast Cancer.

Front Oncol 2022 10;12:899900. Epub 2022 Jun 10.

School of Mathematics, Shandong University, Jinan, China.

Background: With the rapid development and wide application of high-throughput sequencing technology, biomedical research has entered the era of large-scale omics data. We aim to identify genes associated with breast cancer prognosis by integrating multi-omics data.

Method: Gene-gene interactions were taken into account, and we applied two differential network methods JDINAC and LGCDG to identify differential genes. The patients were divided into case and control groups according to their survival time. The TCGA and METABRIC database were used as the training and validation set respectively.

Result: In the TCGA dataset, C11orf1, OLA1, RPL31, SPDL1 and IL33 were identified to be associated with prognosis of breast cancer. In the METABRIC database, ZNF273, ZBTB37, TRIM52, TSGA10, ZNF727, TRAF2, TSPAN17, USP28 and ZNF519 were identified as hub genes. In addition, RPL31, TMEM163 and ZNF273 were screened out in both datasets. GO enrichment analysis shows that most of these hub genes were involved in zinc ion binding.

Conclusion: In this study, a total of 15 hub genes associated with long-term survival of breast cancer were identified, which can promote understanding of the molecular mechanism of breast cancer and provide new insight into clinical research and treatment.
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http://dx.doi.org/10.3389/fonc.2022.899900DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232398PMC
June 2022

Comparison of a Small Dose of Oxycodone and Sufentanil for the Prevention of Sufentanil-Induced Cough during General Anesthesia Induction: A Prospective Randomized Controlled Trial.

Comput Math Methods Med 2022 17;2022:7924643. Epub 2022 Jun 17.

Department of Anesthesiology, Children's Hospital of Nanjing Medical University, Nanjing 210017, China.

Background: Sufentanil is widely used during anesthesia induction. However, it can cause coughing via different mechanisms. This study is aimed at evaluating the effectiveness of a small dose of oxycodone and sufentanil in suppressing sufentanil-induced cough (SIC) during general anesthesia induction.

Methods: Of the 174 patients scheduled for elective surgery, 144 were eligible and randomly divided into 3 groups ( = 48). Five minutes before sufentanil bolus (0.4 g/kg), patients in group O received 0.02  mg/kg oxycodone intravenously within 5 s, those in group S received 0.02 g/kg sufentanil within 5 s, and those in group N received an equal volume of 0.9% normal saline within 5 s. Sufentanil was diluted to 5 g/ml and administered within 5  s after pretreatment. The incidence and severity of cough in the three groups were evaluated within 1 minute after sufentanil injection during the anesthesia induction. Their mean arterial pressure (MAP) and heart rate (HR) were recorded at T0 (after entering the operation), T1 (3 minutes after pretreatment), T2 (before intubation), and T3 (1 minute after intubation).

Results: The incidences of cough in group N, group O, and group S were 20 (41.6%), 7 (14.5%), and 6 (12.5%), respectively. Compared with group N, patients from group O and group S exhibited significantly reduced incidence and severity of cough, and the severity of cough in group O and group S was significantly reduced compared with group N ( < 0.05). No significant differences in the rangeability of MAP and HR were noted at the four time points in the three groups ( > 0.05). Preconditioning using intravenous oxycodone (0.02 mg/kg) or sufentanil (0.02 g/kg) could represent an effective approach to reducing SIC in anesthesia induction and was associated with relatively stable hemodynamic state during general anesthesia. This trial is registered at Chinese Clinical Trial Registry with registration number ChiCTR1900021087.
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http://dx.doi.org/10.1155/2022/7924643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9232308PMC
June 2022

Digital twin rehabilitation system based on self-balancing lower limb exoskeleton.

Technol Health Care 2022 Jun 13. Epub 2022 Jun 13.

Guangdong Provincial Key Lab of Robotics and Intelligent System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Background: The digital twin concept is the virtual model based on entity design measures, which is used in many enterprises' virtual workshop design models for workshop production scheduling and optimization. However, in the field of medical rehabilitation, the integration of digital twin technology started late compared to traditional industrial manufacturing. Many current digital models are not well suited for information interaction between patients and devices.

Objective: In order to address the lack of interaction between patients and devices in the field of medical rehabilitation, this paper proposes an automatic gait data control system (AGDCS) for fully actuated lower limb exoskeleton digital twinning. This system improves the integration of digital twinning system with the medical rehabilitation field and analyzes the patient's gait data through simulation experiments.

Methods: The digital twin system was designed in several steps. Firstly, the upper computer function module was designed and developed according to the rehabilitation treatment needs. After that, the combination of exoskeleton robot and software was carried out, and finally the real rehabilitation treatment environment of patients was simulated through experiments.

Results: The proposed system was very reliable in the experimental tests of the host computer and exoskeleton robot. In the upper computer test, the patient specific gait can be generated, and the motion of the exoskeleton robot can be observed in real-time. During the walking test of the exoskeleton robot, the exoskeleton robot completed the specified gait. The result verified the superiority and effectiveness of the digital twin system AGDCS in the field of rehabilitation.

Conclusions: The digital twin system proposed in this paper improves the interaction between self-balancing exoskeleton robot and patients, and improves the autonomy and safety of patients in rehabilitation treatment.
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http://dx.doi.org/10.3233/THC-220087DOI Listing
June 2022

Structural insight into the individual variability architecture of the functional brain connectome.

Neuroimage 2022 Oct 22;259:119387. Epub 2022 Jun 22.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China; Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University, Beijing 100875, China; IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Chinese Institute for Brain Research, Beijing, 102206, China. Electronic address:

Human cognition and behaviors depend upon the brain's functional connectomes, which vary remarkably across individuals. However, whether and how the functional connectome individual variability architecture is structurally constrained remains largely unknown. Using tractography- and morphometry-based network models, we observed the spatial convergence of structural and functional connectome individual variability, with higher variability in heteromodal association regions and lower variability in primary regions. We demonstrated that functional variability is significantly predicted by a unifying structural variability pattern and that this prediction follows a primary-to-heteromodal hierarchical axis, with higher accuracy in primary regions and lower accuracy in heteromodal regions. We further decomposed group-level connectome variability patterns into individual unique contributions and uncovered the structural-functional correspondence that is associated with individual cognitive traits. These results advance our understanding of the structural basis of individual functional variability and suggest the importance of integrating multimodal connectome signatures for individual differences in cognition and behaviors.
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http://dx.doi.org/10.1016/j.neuroimage.2022.119387DOI Listing
October 2022

In situ 3D bioprinting with bioconcrete bioink.

Nat Commun 2022 06 23;13(1):3597. Epub 2022 Jun 23.

State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang University, 310027, Hangzhou, China.

In-situ bioprinting is attractive for directly depositing the therapy bioink at the defective organs to repair them, especially for occupations such as soldiers, athletes, and drivers who can be injured in emergency. However, traditional bioink displays obvious limitations in its complex operation environments. Here, we design a bioconcrete bioink with electrosprayed cell-laden microgels as the aggregate and gelatin methacryloyl (GelMA) precursor solution as the cement. Promising printability is guaranteed with a wide temperature range benefiting from robust rheological properties of photocrosslinked microgel aggregate and fluidity of GelMA cement. Composite components simultaneously self-adapt to biocompatibility and different tissue mechanical microenvironment. Strong binding on tissue-hydrogel interface is achieved by hydrogen bonds and friction when the cement is photocrosslinked. This bioink owns good portability and can be easily prepared in urgent accidents. Meanwhile, microgels can be cultured to mini tissues and then mixed as bioink aggregates, indicating our bioconcrete can be functionalized faster than normal bioinks. The cranial defects repair results verify the superiority of this bioink and its potential in clinical settings required in in-situ treatment.
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http://dx.doi.org/10.1038/s41467-022-30997-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9225998PMC
June 2022

Functional analysis of arteriovenous fistulae in non-contrast magnetic resonance images.

Comput Methods Programs Biomed 2022 Jul 13;222:106938. Epub 2022 Jun 13.

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA. Electronic address:

Background And Objective: Arteriovenous fistulae (AVF) are the preferred mode of hemodialysis vascular access and their successful maturation is critical to reduce patient morbidity, mortality, cost, and improve quality of life. Peri-anastomotic venous segment stenosis is the primary cause of AVF maturation failure. The objective is to develop a software protocol for the functional analysis of arteriovenous fistula.

Method: We have developed a standard protocol for the anatomical analysis of the AVF to better understand the mechanisms involved in AVF stenosis and to identify future imaging biomarkers for AVF success or failure using non-contrast magnetic resonance imaging (MRI). The 3D model of the AVF is created using a polar dynamic programming technique. Analysis has been performed on six Yorkshire cross domestic swine, but techniques can be applied into clinical settings.

Results: Differences in AVF angles and vein curvature are associated with significant variability of venous cross-sectional area. This suggests that the pattern of stenosis is likely to be dependent upon hemodynamic profiles which are largely determined by AVF anatomical features and could play an important role in AVF maturation.

Conclusions: This protocol enables us to visualize and study the hemodynamic profiles indirectly allowing early stratification of patients into high and low risk groups for AVF maturation failure. High risk patients could then be targeted with an enhanced process of care or future maturation enhancing therapies resulting in a much-needed precision-medicine approach to dialysis vascular access.
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http://dx.doi.org/10.1016/j.cmpb.2022.106938DOI Listing
July 2022

Transfer learning in high-dimensional semiparametric graphical models with application to brain connectivity analysis.

Stat Med 2022 Jun 21. Epub 2022 Jun 21.

Division of Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA.

Transfer learning has drawn growing attention with the target of improving statistical efficiency of one study (dataset) by digging up information from similar and related auxiliary studies (datasets). In this article, we consider transfer learning problem in estimating undirected semiparametric graphical model. We propose an algorithm called Trans-Copula-CLIME for estimating an undirected graphical model while uncovering information from similar auxiliary studies, characterizing the similarity between the target graph and each auxiliary graph by the sparsity of a divergence matrix. The proposed method relaxes the restrictive Gaussian distribution assumption, which deviates from reality for the fMRI dataset related to attention deficit hyperactivity disorder (ADHD) considered here. Nonparametric rank-based correlation coefficient estimators are utilized in the Trans-Copula-CLIME procedure to achieve robustness against normality. We establish the convergence rate of the Trans-Copula-CLIME estimator under some mild conditions, which demonstrates that if the similarity between the auxiliary studies and the target study is sufficiently high and the number of informative auxiliary samples is sufficiently large, the Trans-Copula-CLIME estimator shows great advantage over the existing non-transfer-learning ones. Simulation studies also show that Trans-Copula-CLIME estimator has better performance especially when data are not from Gaussian distribution. Finally, the proposed method is applied to infer functional brain connectivity pattern for ADHD patients in the target Beijing site by leveraging the fMRI datasets from some other sites.
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http://dx.doi.org/10.1002/sim.9499DOI Listing
June 2022

Automatic Detection and Counting of Wheat Spikelet Using Semi-Automatic Labeling and Deep Learning.

Front Plant Sci 2022 30;13:872555. Epub 2022 May 30.

Key Laboratory of Modern Precision Agriculture System Integration Research, Ministry of Education, China Agricultural University, Beijing, China.

The number of wheat spikelets is an important phenotypic trait and can be used to assess the grain yield of the wheat crop. However, manual counting of spikelets is time-consuming and labor-intensive. To develop a cost-effective and highly efficient phenotyping system for counting the number of spikelets under laboratory conditions, methods based on imaging processing techniques and deep learning were proposed to accurately detect and count spikelets from color images of wheat spikes captured at the grain filling stage. An unsupervised learning-based method was first developed to automatically detect and label spikelets from spike color images and build the datasets for the model training. Based on the constructed datasets, a deep convolutional neural network model was retrained using transfer learning to detect the spikelets. Testing results showed that the root mean squared errors, relative root mean squared errors, and the coefficients of determination between the automatic and manual counted spikelets for four wheat lines were 0.62, 0.58, 0.54, and 0.77; 3.96, 3.73, 3.34, and 4.94%; and 0.73, 0.78, 0.84, and 0.67, respectively. We demonstrated that the proposed methods can effectively estimate the number of wheat spikelets, which improves the counting efficiency of wheat spikelets and contributes to the analysis of the developmental characteristics of wheat spikes.
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http://dx.doi.org/10.3389/fpls.2022.872555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189412PMC
May 2022

Scalable Milk-Derived Whey Protein Hydrogel as an Implantable Biomaterial.

ACS Appl Mater Interfaces 2022 Jun 15;14(25):28501-28513. Epub 2022 Jun 15.

Institute of Dairy Science, College of Animal Sciences, Zhejiang University, Hangzhou 310029, China.

There are limited naturally derived protein biomaterials for the available medical implants. High cost, low yield, and batch-to-batch inconsistency, as well as intrinsically differing bioactivity in some of the proteins, make them less beneficial as common implant materials compared to their synthetic counterparts. Here, we present a milk-derived whey protein isolate (WPI) as a new kind of natural protein-based biomaterial for medical implants. The WPI was methacrylated at 100 g bench scale, >95% conversion, and 90% yield to generate a photo-cross-linkable material. WPI-MA was further processed into injectable hydrogels, monodispersed microspheres, and patterned scaffolds with photo-cross-linking-based advanced processing methods including microfluidics and 3D printing. In vivo evaluation of the WPI-MA hydrogels showed promising biocompatibility and degradability. Intramyocardial implantation of injectable WPI-MA hydrogels in a model of myocardial infarction attenuated the pathological changes in the left ventricle. Our results indicate a possible therapeutic value of WPI-based biomaterials and give rise to a potential collaboration between the dairy industry and the production of medical therapeutics.
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http://dx.doi.org/10.1021/acsami.2c02361DOI Listing
June 2022

Towards a fast and generalized microplastic quantification method in soil using terahertz spectroscopy.

Sci Total Environ 2022 Oct 10;841:156624. Epub 2022 Jun 10.

Key Laboratory of Coastal Environment and Resources of Zhejiang Province, School of Engineering, Westlake University, Hangzhou, Zhejiang Province 310024, China; Institute of Advanced Technology, Westlake Institute for Advanced Study, Hangzhou 310024, Zhejiang Province, China. Electronic address:

Extensive investigation of microplastic abundance in soil environment calls for rapid, accurate, efficient and harmonized quantification methods. Development of rapid quantification method requires made-to-measure soil samples with additions of standard polymers. Existing rapid quantification methods ignore the gap between standard polymers in laboratory and household microplastics in soil environment. Here, terahertz (0.6-1.67 thz) and NIR (950-1660 nm) spectroscopy were compared to explore a fast, accurate and potentially generalizable microplastic quantification method in soil. Soil sample was spiked with two standard polymers (polyvinyl chloride (PVC) and polystyrene (PS)) and their additive-containing household microplastics. Two standard sample sets and two household sample sets were prepared in concentrations ranging from 0.5 to 10%. Nine commonly used preprocessing methods and three machine learning algorithms were coupled to develop methods. Models were constructed by training sets from standard sample sets. When models transferred to household samples, prediction error (RMSE) of proposed terahertz method (Wdenosie_PLSR) only increased by 0.4% for PVC and 0.19% for PS, yet that of the NIR method increased by 1.49% and 1.16% respectively. The proposed terahertz method presented a detection limit around 1.12% and the NIR method showed a detection limit around 3.24%. Overall, our results suggest that compared with NIR method, the proposed terahertz method is not only more accurate but also demonstrate stronger generalizability to bridge the gaps between standard PVC/PS polymers and household PVC/PS microplastics. We also propose MMD heatmap for diagnosing spectral preprocessing methods to further improve method efficiency.
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http://dx.doi.org/10.1016/j.scitotenv.2022.156624DOI Listing
October 2022

formed elastin-based hydrogels enhance wound healing via promoting innate immune cells recruitment and angiogenesis.

Mater Today Bio 2022 Jun 21;15:100300. Epub 2022 May 21.

Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, 518107, PR China.

Harnessing the inflammation and angiogenesis is extremely important in wound healing. In this study, we developed bioactive elastin-based hydrogels which can recruit and modulate the innate immune cells and accelerate angiogenesis in the wound site and subsequently improve wound regeneration. These hydrogels were formed by visible-light cross-linking of acryloyl-(polyethylene glycol)-N-hydroxysuccinimide ester modified elastin with methacrylated gelatin, in order to mimic dermal microenvironment. These hydrogels showed highly tunable mechanical properties, swelling ratios and enzymatic degradation profiles, with moduli within the range of human skin. To mimic the degradation of the elastin by elastase from neutrophils, co-culture of the hydrogels and neutrophils was conducted. The derived conditioned medium containing elastin derived peptides (EDP-conditioned medium) promoted the expression of both M1 and M2 markers in M1 macrophages . Additionally, the EDP-conditioned medium induced superior tube formation of endothelia cells in Matrigel. In mice wound model, these elastin-based hydrogels attracted abundant neutrophils and predominant M2 macrophages to the wound and supported their infiltration into the hydrogels. The outstanding immunomodulatory effect of the elastin-based hydrogels resulted in superior angiogenesis, collagen deposition and dermal regeneration. Hence, these elastin-based hydrogels can be a promising regenerative platform to accelerate wound repair.
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http://dx.doi.org/10.1016/j.mtbio.2022.100300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157562PMC
June 2022

The structure, function and expression analysis of the nodulin 26-like intrinsic protein subfamily of plant aquaporins in tomato.

Sci Rep 2022 06 2;12(1):9180. Epub 2022 Jun 2.

Collaborative Innovation Center for Efficient and Green Production of Agriculture in Mountainous Areas of Zhejiang Province, College of Horticulture Science, Zhejiang A&F University, Hangzhou, 311300, Zhejiang, China.

The nodulin 26-like intrinsic protein (NIP) family belonging to a group of aquaporin proteins is unique to plants. NIPs have a wide of transport activities and are involved in developmental processes and stress tolerance. The well reported Lsi1 and Lsi6 belonging to NIP III were characterized as Si transporters. However, except Lsi1 and Lsi6, most NIPs remain unknown. Here, we identified 43 putative aquaporins in tomato. We found there are 12 NIPs, including 8 NIP I proteins, 3 NIP II proteins, and 1 NIP III protein among the 43 aquaporins. Also, there are two Si efflux transporters SlLsi2-1 and SlLsi2-2 identified by using Lsi2 proteins from other species. By analysing the phylogenetic relationships, conserved residues and expression patterns, we propose that three NIP I members (SlNIP-2, SlNIP-3 and SlNIP-11) may transport water, ammonia, urea, and boric acid, and contribute to pollen development. Three NIP II proteins (SlNIP-7, SlNIP-9 and SlNIP-12) may be boric acid facilitators, and affect plant growth and anther development. Overall, the study provides valuable candidates of Si transporters and other NIP proteins to further explore their roles in uptake and transport for silicon, boron, and other substrates in tomato.
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http://dx.doi.org/10.1038/s41598-022-13195-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163140PMC
June 2022

Learning to read may help promote attention by increasing the volume of the left middle frontal gyrus and enhancing its connectivity to the ventral attention network.

Cereb Cortex 2022 Jun 1. Epub 2022 Jun 1.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Xinjiekouwai St, Haidian District, Beijing 100875, China.

Attention and reading are essential skills for successful schooling and in adult life. While previous studies have documented that attention development supports reading acquisition, whether and how learning to read may improve attention among school-age children and the brain structural and functional development that may be involved remain unknown. In this prospective longitudinal study, we examined bidirectional and longitudinal predictions between attention and reading development and the neural mediators of attention and reading development among school-age children using cross-lagged panel modeling. The results showed that better baseline reading performance significantly predicted better attention performance one year later after controlling for baseline attention performance. In contrast, after controlling for baseline reading performance, attention did not significantly predict reading performance one year later, while more attention problems also significantly predicted worse reading performance. Both the increasing gray matter volume of the left middle frontal gyrus and the increasing connectivity between the left middle frontal gyrus and the ventral attention network mediated the above significant longitudinal predictions. This study, directly revealed that reading skills may predict the development of important cognitive functions, such as attention, in school-age children. Therefore, learning to read is not only a challenge for school-age children but is also an important way to optimize attention and brain development.
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http://dx.doi.org/10.1093/cercor/bhac206DOI Listing
June 2022

68Ga-FAPI-04 PET/CT in Epithelioid Hemangioendothelioma With Pleura and Bone Metastases.

Clin Nucl Med 2022 May 27. Epub 2022 May 27.

From the Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, People's Republic of China.

Abstract: Epithelioid hemangioendothelioma is a low- to intermediate-grade malignant vascular tumor with a slowly progressive course and unpredictable prognosis. We report a case of epithelioid hemangioendothelioma with pleura and bone metastases on 68Ga-FAPI-04 PET/CT in a 65-year-old woman who underwent surgery and chemotherapy.
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http://dx.doi.org/10.1097/RLU.0000000000004284DOI Listing
May 2022

Migration, Schizophrenia, and Crime: A Study From a Forensic Psychiatric Sample.

Front Psychiatry 2022 6;13:869978. Epub 2022 May 6.

Department of Forensic Psychiatry, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Sichuan, China.

Background: The association between mental health problems and crime in immigrants has attracted recent academic interest, with results suggesting that there were possible interactions between immigration, schizophrenia, and criminal behavior. However, very few studies have examined these interactions, especially in developing countries that have mass internal immigration. Therefore, this study sought to identify the associations between the sociodemographic, clinical, and criminal factors in migrants and non-migrants with schizophrenia who had been involved in criminal activities in China.

Methods: Forensic archives of suspects who had been referred for criminal responsibility assessments in the Sichuan West China Forensic Center from January 2015 to December 2019 were reviewed. The sociodemographic, and criminal activity information of the suspects were extracted, while the clinical and social function were measured by the Brief Psychiatric Rating Scale (BPRS) and Social Disability Screening Schedule (SDSS) based on the archives. A Chi-squared test, a T-test, a Mann-Whitney U test, and Multinomial logistic regression were employed for the statistical analysis.

Results: A total of 552 patients were reviewed and evaluated, 17.2% ( = 95) of which were migrants. The migrant patient group was younger than the non-migrant patient group. The BPRS and SDSS scores for the migrant patient group were lower than for the non-migrant patient group. The migrant patient group had more work experience and more had been employed at the time of the crime than the non-migrant patient group. The unemployed migrant patients were more likely to commit a property-related crime.

Conclusions: Compared to the non-migrant schizophrenia patient group, the migrant patient group had less severe psychiatric symptoms and less social function impairments. Employment was an important factor in preventing criminality in patients with schizophrenia, especially for migrant patients. Vocational rehabilitation focuses on developing appropriate employment that can significantly assist in schizophrenia patient recovery, which in turn could reduce their chances of committing crime. Besides, reducing other obstacles to stigma, housing and health insurance would also be beneficial to crime reduction.
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http://dx.doi.org/10.3389/fpsyt.2022.869978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9120637PMC
May 2022
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