Yonehiro Kanemura

Yonehiro Kanemura

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Yonehiro Kanemura

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Evaluation of the susceptibility of neurons and neural stem/progenitor cells derived from human induced pluripotent stem cells to anticancer drugs.

J Pharmacol Sci 2019 Aug 21. Epub 2019 Aug 21.

Division of Regenerative Medicine, Department of Biomedical Research and Innovation, Institute for Clinical Research, National Hospital Organization Osaka National Hospital, Osaka 540-0006, Japan; Department of Neurosurgery, National Hospital Organization Osaka National Hospital, Osaka 540-0006, Japan; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2019.08.002DOI Listing
August 2019

Review of ependymomas: assessment of consensus in pathological diagnosis and correlations with genetic profiles and outcome.

Brain Tumor Pathol 2019 Apr 30;36(2):92-101. Epub 2019 Mar 30.

Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.

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http://dx.doi.org/10.1007/s10014-019-00338-xDOI Listing
April 2019

Review of ependymomas: assessment of consensus in pathological diagnosis and correlations with genetic profiles and outcome.

Brain Tumor Pathol 2019 Apr 30;36(2):92-101. Epub 2019 Mar 30.

Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Saitama, Japan.

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http://dx.doi.org/10.1007/s10014-019-00338-xDOI Listing
April 2019

LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors.

Cancer Res 2018 12 9;78(23):6607-6620. Epub 2018 Oct 9.

Department of Signal Transduction, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0498DOI Listing
December 2018

Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.

Acta Neuropathol Commun 2018 12 4;6(1):134. Epub 2018 Dec 4.

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

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https://actaneurocomms.biomedcentral.com/articles/10.1186/s4
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http://dx.doi.org/10.1186/s40478-018-0630-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278135PMC
December 2018

A novel homozygous missense mutation in the SH3-binding motif of STAMBP causing microcephaly-capillary malformation syndrome.

J Hum Genet 2018 Sep 15;63(9):957-963. Epub 2018 Jun 15.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1038/s10038-018-0482-3DOI Listing
September 2018

BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation.

Cancer Cell 2018 06;33(6):1004-1016.e5

Laboratory of Molecular Neuro-Oncology, Department of Neurosurgery, School of Medicine, Emory University, Atlanta, GA 30322, USA; Winship Cancer Institute, Emory University, 1365C Clifton Road N.E, C5078, Atlanta, GA 30322, USA; Department of Hematology & Medical Oncology, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15356108183022
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http://dx.doi.org/10.1016/j.ccell.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002773PMC
June 2018

Enlargement of papillary glioneuronal tumor in an adult after a follow-up period of 10 years: a case report.

J Surg Case Rep 2018 Jun 13;2018(6):rjy123. Epub 2018 Jun 13.

Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan.

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http://dx.doi.org/10.1093/jscr/rjy123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007277PMC
June 2018

Grip and slip of L1-CAM on adhesive substrates direct growth cone haptotaxis.

Proc Natl Acad Sci U S A 2018 03 26;115(11):2764-2769. Epub 2018 Feb 26.

Laboratory of Systems Neurobiology and Medicine, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma 630-0192, Japan;

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http://dx.doi.org/10.1073/pnas.1711667115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856512PMC
March 2018

Enchondromatosis-associated oligodendroglioma: case report and literature review.

Brain Tumor Pathol 2018 Jan 9;35(1):36-40. Epub 2017 Dec 9.

Department of Neurosurgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

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http://link.springer.com/10.1007/s10014-017-0303-y
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http://dx.doi.org/10.1007/s10014-017-0303-yDOI Listing
January 2018

Small-scale screening of anticancer drugs acting specifically on neural stem/progenitor cells derived from human-induced pluripotent stem cells using a time-course cytotoxicity test.

PeerJ 2018 4;6:e4187. Epub 2018 Jan 4.

Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan.

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http://dx.doi.org/10.7717/peerj.4187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756610PMC
January 2018

Establishment of a tumor sphere cell line from a metastatic brain neuroendocrine tumor.

Med Mol Morphol 2017 Dec 17;50(4):211-219. Epub 2017 May 17.

Department of Neurosurgery, Kansai Medical University, Hirakata, Japan.

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http://dx.doi.org/10.1007/s00795-017-0160-0DOI Listing
December 2017

Siblings with optic neuropathy and RTN4IP1 mutation.

J Hum Genet 2017 Oct 22;62(10):927-929. Epub 2017 Jun 22.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2017.68DOI Listing
October 2017

A novel genetic syndrome with STARD9 mutation and abnormal spindle morphology.

Am J Med Genet A 2017 Oct 4;173(10):2690-2696. Epub 2017 Aug 4.

National Institute of Genetics, Department of Molecular Genetics, Division of Centrosome Biology, Mishima, Shizuoka, Japan.

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http://dx.doi.org/10.1002/ajmg.a.38391DOI Listing
October 2017

A novel missense mutation in the HECT domain of NEDD4L identified in a girl with periventricular nodular heterotopia, polymicrogyria and cleft palate.

J Hum Genet 2017 Sep 18;62(9):861-863. Epub 2017 May 18.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1038/jhg.2017.53DOI Listing
September 2017

Visualization of migration of human cortical neurons generated from induced pluripotent stem cells.

J Neurosci Methods 2017 Sep 8;289:57-63. Epub 2017 Jul 8.

Division of Molecular Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan.

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http://dx.doi.org/10.1016/j.jneumeth.2017.07.004DOI Listing
September 2017

Novel MCA/ID syndrome with ASH1L mutation.

Am J Med Genet A 2017 Jun 10;173(6):1644-1648. Epub 2017 Apr 10.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1002/ajmg.a.38193DOI Listing
June 2017

Molecular Biology of Pediatric Hydrocephalus and Hydrocephalus-related Diseases.

Neurol Med Chir (Tokyo) 2015 31;55(8):640-6. Epub 2015 Jul 31.

Department of Pediatric Neurosurgery, Takatsuki General Hospital.

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http://dx.doi.org/10.2176/nmc.ra.2015-0075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628154PMC
April 2017

Diagnosis of Brain Tumors Using Amino Acid Transport PET Imaging with F-fluciclovine: A Comparative Study with L-methyl-C-methionine PET Imaging.

Asia Ocean J Nucl Med Biol 2017 ;5(2):85-94

Department of neurosyrgery, Kansai Molecular Diagnosis Network for CNS Tumors, Osaka National Hospital, Osaka, Japan.

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http://dx.doi.org/10.22038/aojnmb.2017.8843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5482923PMC
January 2017

Pediatric thalamic glioma with H3F3A K27M mutation, which was detected before and after malignant transformation: a case report.

Childs Nerv Syst 2016 Dec 8;32(12):2433-2438. Epub 2016 Jul 8.

Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku, Osaka, 540-0006, Japan.

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http://dx.doi.org/10.1007/s00381-016-3161-8DOI Listing
December 2016

Molecular Classification of Medulloblastoma.

Neurol Med Chir (Tokyo) 2016 Nov 26;56(11):687-697. Epub 2016 May 26.

Department of Neurosurgery, Osaka National Hospital, National Hospital Organization.

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http://dx.doi.org/10.2176/nmc.ra.2016-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221779PMC
November 2016

[Molecular biology of brain tumors].

Nihon Rinsho 2016 09;74 Suppl 7:103-111

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September 2016

[Efficacy of interferon in the treatment of malignant glionas].

Nihon Rinsho 2016 09;74 Suppl 7:695-698

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September 2016

Novel splicing mutation in the ASXL3 gene causing Bainbridge-Ropers syndrome.

Am J Med Genet A 2016 07 13;170(7):1863-7. Epub 2016 Apr 13.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

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http://dx.doi.org/10.1002/ajmg.a.37653DOI Listing
July 2016

Rapid regression of glioblastoma following carmustine wafer implantation: A case report.

Mol Clin Oncol 2016 Jul 10;5(1):153-157. Epub 2016 May 10.

Department of Neurological Surgery, Wakayama Medical University School of Medicine, Wakayama, Wakayama 641-0012, Japan.

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http://dx.doi.org/10.3892/mco.2016.894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906772PMC
July 2016

Establishment of Human Neural Progenitor Cells from Human Induced Pluripotent Stem Cells with Diverse Tissue Origins.

Stem Cells Int 2016 26;2016:7235757. Epub 2016 Apr 26.

Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan; Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.

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http://dx.doi.org/10.1155/2016/7235757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861799PMC
May 2016

Truncating mutation in NFIA causes brain malformation and urinary tract defects.

Hum Genome Var 2015 26;2:15007. Epub 2015 Feb 26.

Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences , Nagoya, Japan.

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http://dx.doi.org/10.1038/hgv.2015.7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785547PMC
April 2016

A case of pilocytic astrocytoma requiring tumor resection during pregnancy.

Mol Clin Oncol 2016 Apr 9;4(4):567-570. Epub 2016 Feb 9.

Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.

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http://dx.doi.org/10.3892/mco.2016.773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812212PMC
April 2016

Choroid Plexus Metastasis of Follicular Thyroid Carcinoma Diagnosed due to Intraventricular Hemorrhage.

Intern Med 2015 15;54(10):1297-302. Epub 2015 May 15.

Department of Neurosurgery, National Hospital Organization Osaka National Hospital, Japan.

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http://dx.doi.org/10.2169/internalmedicine.54.3560DOI Listing
December 2015

Generation of cerebral cortex - like structure from human pluripotent stem cells.

Nihon Rinsho 2015 Jun;73 Suppl 5:130-4

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June 2015

Primary microcephaly with anterior predominant pachygyria caused by novel compound heterozygous mutations in ASPM.

Pediatr Neurol 2015 May 7;52(5):e7-8. Epub 2015 Feb 7.

Department of Pediatrics, Yamagata University Faculty of Medicine, Yamagata, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.pediatrneurol.2015.01.019DOI Listing
May 2015

Efficacy of temozolomide and bevacizumab for the treatment of leptomeningeal dissemination of recurrent glioblastoma: A case report.

Oncol Lett 2015 Apr 6;9(4):1885-1888. Epub 2015 Feb 6.

Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka 540-0006, Japan.

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http://dx.doi.org/10.3892/ol.2015.2940DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356381PMC
April 2015

Sudden death in a case of megalencephaly capillary malformation associated with a de novo mutation in AKT3.

Childs Nerv Syst 2015 Mar 22;31(3):465-71. Epub 2014 Nov 22.

Department of Pediatric Neurosurgery, Takatsuki General Hospital, 1-3-13 Kosobecho, Takatsuki City, Osaka, 569-1192, Japan.

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http://dx.doi.org/10.1007/s00381-014-2589-yDOI Listing
March 2015

Ipsilateral hemiparesis caused by putaminal hemorrhage in a patient with horizontal gaze palsy with progressive scoliosis: a case report.

BMC Neurol 2015 Mar 10;15:25. Epub 2015 Mar 10.

Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku, Osaka City, 540-0006, Japan.

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http://bmcneurol.biomedcentral.com/articles/10.1186/s12883-0
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http://dx.doi.org/10.1186/s12883-015-0286-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356136PMC
March 2015

Prenatal molecular diagnosis of X-linked hydrocephalus via a silent C924T mutation in the L1CAM gene.

Congenit Anom (Kyoto) 2014 Nov;54(4):243-5

Department of Obstetrics and Gynecology, Niigata University Medical and Dental Hospital, Niigata, Japan.

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http://dx.doi.org/10.1111/cga.12069DOI Listing
November 2014

KIF1A mutation in a patient with progressive neurodegeneration.

J Hum Genet 2014 Nov 25;59(11):639-41. Epub 2014 Sep 25.

Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2014.80DOI Listing
November 2014

(11)C-methinine uptake correlates with MGMT promoter methylation in nonenhancing gliomas.

Clin Neurol Neurosurg 2014 Oct 10;125:212-6. Epub 2014 Aug 10.

Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku, Osaka City 540-0006, Japan; Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku, Osaka City 540-0006, Japan.

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http://dx.doi.org/10.1016/j.clineuro.2014.08.004DOI Listing
October 2014

Differentiation, polarization, and migration of human induced pluripotent stem cell-derived neural progenitor cells co-cultured with a human glial cell line with radial glial-like characteristics.

Biochem Biophys Res Commun 2014 May 19;447(4):683-8. Epub 2014 Apr 19.

Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan; Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.04.070DOI Listing
May 2014

Brain malformation with loss of normal FGFR3 expression in thanatophoric dysplasia type I.

Neuropathology 2013 Dec 1;33(6):663-6. Epub 2013 Apr 1.

Department of Pathology & Applied Neurobiology, Kyoto Prefectural University of Medicine, Graduate School of Medical Sciences, Kyoto, Japan.

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http://dx.doi.org/10.1111/neup.12036DOI Listing
December 2013

Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem Cells.

Cell Med 2013 Mar 1;4(3):125-47. Epub 2012 Nov 1.

†Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan; ##Department of Neurosurgery, Osaka National Hospital, National Hospital Organization, Osaka, Japan.

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http://dx.doi.org/10.3727/215517912X658918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4733846PMC
March 2013

A method for efficiently generating neurospheres from human-induced pluripotent stem cells using microsphere arrays.

Neuroreport 2013 Jan;24(2):84-90

Division of Stem Cell Research, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan.

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http://dx.doi.org/10.1097/WNR.0b013e32835cb677DOI Listing
January 2013

Macrophage migration inhibitory factor (MIF) promotes cell survival and proliferation of neural stem/progenitor cells.

J Cell Sci 2012 Jul 27;125(Pt 13):3210-20. Epub 2012 Mar 27.

Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Japan.

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http://dx.doi.org/10.1242/jcs.102210DOI Listing
July 2012

Hydrocephalus with Hirschsprung disease: severe end of X-linked hydrocephalus spectrum.

Am J Med Genet A 2012 Apr 21;158A(4):812-5. Epub 2012 Feb 21.

Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.1002/ajmg.a.35245DOI Listing
April 2012

Isolation and cellular properties of mesenchymal cells derived from the decidua of human term placenta.

Differentiation 2011 Sep;82(2):77-88

Department of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.

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http://dx.doi.org/10.1016/j.diff.2011.05.010DOI Listing
September 2011

[Cell therapy for central nervous system disorders].

No Shinkei Geka 2011 Jan;39(1):5-23

Department of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Japan.

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January 2011

Development of cell-processing systems for human stem cells (neural stem cells, mesenchymal stem cells, and iPS cells) for regenerative medicine.

Keio J Med 2010 ;59(2):35-45

Department of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Chuo-ku, Osaka, Japan.

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October 2010

Effect of microwell chip structure on cell microsphere production of various animal cells.

J Biosci Bioeng 2010 Aug 25;110(2):223-9. Epub 2010 Feb 25.

Department of Life and Environment Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu-ku, Kitakyushu 808-0135, Japan.

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http://dx.doi.org/10.1016/j.jbiosc.2010.01.021DOI Listing
August 2010

ABCB1 is predominantly expressed in human fetal neural stem/progenitor cells at an early development stage.

J Neurosci Res 2009 Sep;87(12):2615-23

Department of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan.

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http://dx.doi.org/10.1002/jnr.22094DOI Listing
September 2009

Hirschsprung's disease, acrocallosal syndrome, and congenital hydrocephalus: report of 2 patients and literature review.

J Pediatr Surg 2008 May;43(5):E13-7

Department of Pediatric Surgery, Neurosurgery, First Surgery, Hokkaido University Graduate School of Medicine, Sapporo, 060-8648, Japan.

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http://dx.doi.org/10.1016/j.jpedsurg.2007.12.069DOI Listing
May 2008

Recombination rates of genes expressed in human tissues.

Hum Mol Genet 2008 Feb 13;17(4):577-86. Epub 2007 Nov 13.

SNP Research Center, RIKEN, 1-7-22 Suehiro, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

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http://dx.doi.org/10.1093/hmg/ddm332DOI Listing
February 2008

Identification of a neuron-specific human gene, KIAA1110, that is a guanine nucleotide exchange factor for ARF1.

Biochem Biophys Res Commun 2007 Dec 15;364(4):737-42. Epub 2007 Oct 15.

Neuroimmunology Research Group, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2007.10.041DOI Listing
December 2007

Observational examination of aggregation and migration during early phase of neurosphere culture of mouse neural stem cells.

J Biosci Bioeng 2007 Sep;104(3):231-4

Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka 560-8531, Japan.

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http://dx.doi.org/10.1263/jbb.104.231DOI Listing
September 2007

Early response of neural stem/progenitor cells after X-ray irradiation in vitro.

Neuroreport 2007 Jun;18(9):895-900

Department of Applied Biochemistry, Graduate School of Agriculture, Osaka Prefecture University, Sakai, Osaka, Japan.

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http://dx.doi.org/10.1097/WNR.0b013e3281053c34DOI Listing
June 2007

Image cytometry for analyzing regional distribution of cells inside human neurospheres.

J Biosci Bioeng 2007 Apr;103(4):384-7

Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.

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http://dx.doi.org/10.1263/jbb.103.384DOI Listing
April 2007

Effect of neurosphere size on the growth rate of human neural stem/progenitor cells.

J Neurosci Res 2006 Dec;84(8):1682-91

Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan.

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http://dx.doi.org/10.1002/jnr.21082DOI Listing
December 2006

Molecular mechanisms and neuroimaging criteria for severe L1 syndrome with X-linked hydrocephalus.

J Neurosurg 2006 Nov;105(5 Suppl):403-12

Institute for Clinical Research and Department of Neurosurgery, Osaka National Hospital, Osaka, Japan.

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http://dx.doi.org/10.3171/ped.2006.105.5.403DOI Listing
November 2006

Upregulation of macrophage migration inhibitory factor and calgizzarin by androgen in TM4 mouse Sertoli cells.

Asian J Androl 2006 Sep 5;8(5):549-54. Epub 2006 Jun 5.

Department of Obstetrics and Gynecology, Hyogo College of Medicine, 1-1 mukogawa-cho, Nishinomiya 663-8501, Japan.

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http://dx.doi.org/10.1111/j.1745-7262.2006.00196.xDOI Listing
September 2006