Publications by authors named "Yoko Yamazaki"

24 Publications

  • Page 1 of 1

[A Case Report of Kampo Medicine Improving the Symptoms of Antiresorptive Agent-related Osteonecrosis of the Jaw (ARONJ)].

Yakugaku Zasshi 2021 ;141(9):1123-1127

Department of Orofacial Pain Clinic, Dental Hospital, Tokyo Medical and Dental University.

A 56-year-old woman visited an oral surgery clinic in October X with sudden pain in the left mandible. She was diagnosed with left mandibular osteomyelitis based on head computed tomography examination findings. The pain did not reduce even with amoxicillin and loxoprofen sodium hydrate. The patient was then referred to our clinic for treatment. Hainosankyuto (7.5 g/d), loxoprofen sodium hydrate (180 mg/d), and mecobalamin (1500 μg/d) alleviated the pain. However, numbness and tingling pain in the left part of the chin increased. Pregabalin 50 mg/d was then prescribed and then increased from 50 to 100 mg/d. The patient was diagnosed with antiresorptive agent-related osteonecrosis of the jaw (ARONJ). As the pain was exacerbated by discontinuation of the hainosankyuto, it was used continuously. The patient experienced no pain, even after discontinuing the mecobalamin and pregabalin. Platycodon root in hainosankyuto promotes drainage. The patient did not show any significant swelling because she took hainosankyuto during the early stages of inflammation. In addition, the pain resolved even when only hainosankyuto was used, possibly due to the analgesic effect of platycodon root, glycyrrhiza root, and peony root. Hainosankyuto may be an effective adjunctive treatment for patients with ARONJ whose pain is difficult to control with general treatment.
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http://dx.doi.org/10.1248/yakushi.21-00128DOI Listing
January 2021

Later chronotype is associated with unhealthful plant-based diet quality in young Japanese women.

Appetite 2021 11 16;166:105468. Epub 2021 Jun 16.

Division of Life Sciences, Graduate School of Humanities and Sciences, Ochanomizu University, 2-1-1 Otsuka Bunkyo-ku, Tokyo, 112-8610, Japan.

Background: Having a late chronotype, that is, the tendency to go to sleep and wake up at later hours, influences an individual's physical and mental health. Despite a few studies noting the association of chronotype with healthy dietary patterns, this relationship remains unclear.

Purpose: This study aimed to describe the association of chronotype with healthful and unhealthful plant-based diet quality in female Japanese undergraduate students.

Design: Cross-sectional.

Participants And Setting: A total of 218 female university students in Tokyo, Japan.

Main Outcome Measures: Healthful and unhealthful plant-based dietary index-Japanese version (hPDI-J and uPDI-J), calculated using the validated brief-type self-administered diet history questionnaire.

Statistical Analyses Performed: A five-model stepwise multiple linear regression analysis was conducted. Independent variables were hPDI-J and uPDI-J scores, and dependent variables were various lifestyle habits related to the circadian rhythm and demographic characteristics.

Results: Mean (standard deviation) sleep duration, midpoint of sleep, sleep latency time, and social jetlag were 411 (60) min, 03:56 (00:57), 21 (27) min, and 50 (39) min, respectively. Chronotype and several variables, such as residential status, energy and alcohol intake, and nutritional knowledge, were associated with healthful and unhealthful plant-based diet quality. Individuals who had higher hPDI-J scores were more likely to have an earlier chronotype (β = -0.168, P = 0.019) and better nutritional knowledge (β = 0.164, P = 0.022) than those with lower hPDI-J scores. Individuals were more likely to have higher uPDI-J scores if they were living alone (β = -0.301, P < 0.001), had a later chronotype (β = 0.181, P = 0.001), higher frequency of snacking (β = 0.164, P = 0.019), lower total energy (β = -0.445, P < 0.001), and worse nutritional knowledge (β = -0.172, P = 0.001).

Conclusion: This study provided new evidence as to the relationship between sleep and dietary habits, the interaction of which may affect women's health.
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http://dx.doi.org/10.1016/j.appet.2021.105468DOI Listing
November 2021

Is mindful eating sustainable and healthy? A focus on nutritional intake, food consumption, and plant-based dietary patterns among lean and normal-weight female university students in Japan.

Eat Weight Disord 2021 Oct 9;26(7):2183-2199. Epub 2021 Jan 9.

Organization for Human Life Innovation and Development, 2-1-1 Otsuka, Bunkyo-ku, Tokyo, 112-8610, Japan.

Purpose: This study aimed to investigate the correlation between mindful eating and nutritional intake, food consumption, and healthful and unhealthful plant-based dietary patterns in young Japanese women.

Methods: The sample comprised 215 female undergraduates who responded to a two-questionnaire anonymous survey conducted in Tokyo, Japan in 2018 and 2019 from November to December. We measured mindful eating status using the Expanded Mindful Eating Scale (EMES) and used Japanese plant-based dietary indices to determine plant-based dietary patterns. Partial correlation analyses were conducted to determine the correlation of mindful eating with energy and nutrient intake, food consumption, and plant-based dietary patterns, after adjusting for demographics and body mass index.

Results: Participants with higher sub-scores in "health of the planet" and "awareness and appreciation for food" ate higher quantities of several micronutrients and plant-based foods and were more likely to have a healthful plant-based dietary pattern. They were also less likely to have an unhealthful plant-based dietary pattern. In contrast, participants with higher scores in "non-judgmental awareness" ate less protein, whole grains, and vegetables, and were likely to have an unhealthful plant-based dietary pattern.

Conclusion: This study is the first to show that young Japanese women with normal or lean body weight were more likely to consume healthful plant-based foods when they ate mindfully.

Level V: Opinions of respected authorities, based on descriptive studies, narrative reviews, clinical experience, or reports of expert committees.
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http://dx.doi.org/10.1007/s40519-020-01093-1DOI Listing
October 2021

Examination of pain relief effect of Goreisan for glossodynia.

Medicine (Baltimore) 2020 Aug;99(33):e21536

Nagasaki University Hospital, Clinical Research Center, Nagasaki, Japan.

Background: Pain in glossodynia may be severe; it may prevent patients from working, interfere with daily life activities, and necessitate a patient's visit to a medical institution for consultation and treatment. The pain may be described as persistent and burning (tingling, tingling) or stinging. Patients may complain of dry mouth (dryness), which is thought to cause inflammation of the tongue and gingival mucous membranes and increased pain. Medications are prescribed based on the symptoms of glossodynia, and the therapeutic effect is confirmed. However, each drug has side effects, for example, pain may reduce, but drowsiness and dizziness may occur; further, there is always a tendency of drowsiness.On the other hand, Goreisan, a Chinese herbal medicine, has already been used by physicians to treat pain in the oral and maxillofacial regions resulting from rapid changes in air pressure. However, the lack of high-quality clinical research has been of concern, and a randomized clinical trial to investigate the efficacy and safety of Goreisan for treatment of pain in glossodynia is warranted.

Methods/design: This multicenter, randomized, controlled study will involve patients treated for glossodynia-related pain. In the experimental group, Goreisan will be taken for 12 weeks in combination with conventional treatment. Participants in the control group will not take any Kampo medicine; only the standard treatment will be taken. Subsequently, the degree of pain will be assessed, and saliva tests of all the patients on their first visit will be performed. Goreisan will be taken at a dose of 7.5 g/d (minute 3) for 12 consecutive weeks. Twelve weeks later, the degree of pain of each patient will be assessed.

Discussion: The purpose of this study is to investigate the efficacy of Goreisan for pain reduction in patients undergoing treatment for glossodynia-related pain. If pain in glossodynia patients can be reduced by the administration of Goreisan, its candidacy as an alternative treatment for pain in glossodynia can be further supported by more reliable research.

Trial Registration: The study was registered in the jRCTs071200017. URL https://jrct.niph.go.jp/latest-detail/jRCTs071200017.
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http://dx.doi.org/10.1097/MD.0000000000021536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7437797PMC
August 2020

Development and validation of the Expanded Mindful Eating Scale.

Int J Health Care Qual Assur 2020 Jul;ahead-of-print(ahead-of-print)

Faculty of Core Research, Ochanomizu University, Tokyo, Japan.

Purpose: To develop and validate the Expanded Mindful Eating Scale (EMES), an expanded mindful eating model created for the promotion of health and sustainability.

Design/methodology/approach: A cross-sectional study using self-administered questionnaire surveys on Ochanomizu Health Study (OHS) was conducted. The survey was provided to 1,388 female university students in Tokyo, Japan. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and a partial correlation analysis were used to confirm construct and criterion validity. Internal consistency of the EMES was confirmed to calculate Cronbach's alpha.

Findings: The response rate was 38.7 % ( = 537). Mean BMI was 20.21 ± 2.12, and 18.8% of them were classified as "lean" (BMI < 18.5). The authors listed 25 items and obtained a final factor structure of five factors and 20 items, as a result of EFA. Through CFA, the authors obtained the following fit indices for a final model: GFI = 0.914, AGFI = 0.890, CFI = 0.870 and RMSEA = 0.061. The total EMES score was significantly correlated with BMI, mindfulness, body dissatisfaction, drive for thinness and life satisfaction ( = -0.138, -0.315, -0.339, -0.281 and 0.149,  < 0.01, respectively). Cronbach's alpha for all items in this scale was 0.687.

Practical Implications: The authors suggest the possibility that practitioners and researchers of mindful eating that includes this new concept can use authors' novel scale as an effective measurement tool.

Originality/value: The EMES, which can multidimensionally measure the concept of the expanded model of mindful eating was first developed in this study.
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http://dx.doi.org/10.1108/IJHCQA-01-2020-0009DOI Listing
July 2020

Feelings of siblings having a brother/sister with Down syndrome.

Arch Psychiatr Nurs 2019 08 24;33(4):337-346. Epub 2019 Jan 24.

Graduates School Department of Interdisciplinary Research, University of Yamanashi, Japan.

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http://dx.doi.org/10.1016/j.apnu.2019.01.001DOI Listing
August 2019

Developmental changes in fat talk to avoid peer rejection in Japanese girls and young women.

Health Psychol Open 2019 Jan-Jun;6(1):2055102919854170. Epub 2019 Jun 5.

Ochanomizu University, Japan.

"Fat talk" refers to conversations focused on body disparagement. We examined developmental changes in fat talk to avoid social rejection and the mediating role of fat talk between "thin-ideal" internalization and body dissatisfaction. A total of 214 high school girls and 227 college-aged women completed questionnaires assessing fat talk engagement, body dissatisfaction, thin-ideal internalization, and sensitivity to rejection. Path analyses showed that fat talk mediated between thin-ideal internalization and body dissatisfaction and that rejection sensitivity predicted fat talk among high school girls, but not among college women. The purpose of fat talk differed by developmental stage, suggesting that interventions for improving body image should be developmentally tailored.
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http://dx.doi.org/10.1177/2055102919854170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552365PMC
June 2019

Effects of exercise therapy on painful temporomandibular disorders.

J Oral Rehabil 2019 May 19;46(5):475-481. Epub 2019 Feb 19.

Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.

Temporomandibular disorders (TMD) are common chronic musculoskeletal pain conditions among orofacial pain. Painful TMD condition such as myalgia and arthralgia can be managed by exercise therapy. However, as it is hard to access actual effect of each modality that is included in an exercise therapy programme due to multiple choice of the management modality, their efficacy remains controversial. Therefore, this review focused on the effects of exercise therapy for the management of painful TMD. The aims of this review were to summarise the effects of exercise therapy for major symptoms of painful TMD and to establish a guideline for the management of painful TMD, resulting in higher quality and reliability of dental treatment. In this review, exercise modalities are clearly defined as follows: mobilisation exercise, muscle strengthening exercise (resistance training), coordination exercise and postural exercise. Furthermore, pain intensity and range of movements were focused as outcome parameters in this review. Mobilisation exercise including manual therapy, passive jaw mobilisation with oral appliances and voluntary jaw exercise appeared to be a promising option for painful TMD conditions such as myalgia and arthralgia. This review addressed not only the effects of exercise therapy on various clinical conditions of painful TMD shown in the past, but also an urgent need for consensus among dentists and clinicians in terms of the management of each condition, as well as terminology.
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http://dx.doi.org/10.1111/joor.12770DOI Listing
May 2019

Perceptions and Feelings of Fathers of Children With Down Syndrome.

Arch Psychiatr Nurs 2016 10 25;30(5):544-51. Epub 2016 Apr 25.

Faculty of Medicine, University of Yamanashi.

Purpose: This study aimed to obtain information about the lives of families with children with Down syndrome through interviews with the fathers.

Methods: The participants were 9 fathers who were recruited from the local Association of Parents of Down syndrome. Their children were born between 1996 and 2009. The study used a descriptive exploratory design utilizing a focus group.

Results: Through analysis of the fathers' transcripts, 7 major themes emerged: 1) crisis of life, 2) emotional turmoil, 3) attitudes toward the disability, 4) parental responsibility, 5) realization of fatherhood, 6) difference of feelings between mother and father, and 7) contact with people.

Conclusions: Fathers were upset with the fact that their children were born with Down syndrome. However, they accepted fatherhood through child-rearing in cooperation with others. The experience of fathers in this study provides practical points for caring for families with children with Down syndrome.
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http://dx.doi.org/10.1016/j.apnu.2016.04.006DOI Listing
October 2016

Thin-ideal internalization and body dissatisfaction in Sri Lankan adolescents.

J Health Psychol 2017 12 27;22(14):1830-1840. Epub 2016 Mar 27.

2 University of Colombo, Sri Lanka.

In this study, a survey of Sri Lankan adolescents explored relationships between thin-ideal internalization and body dissatisfaction-issues that have received greater research attention in East Asia and the West. Girls scored lower in thin-ideal internalization and awareness and higher in self-esteem compared to boys; however, unlike in previous studies, body dissatisfaction did not differ significantly by gender. Hierarchical linear multiple regression analyses revealed that self-esteem moderated the relationship between thin-ideal internalization and body dissatisfaction among girls, but this was not observed for boys. Self-esteem as a protective factor against body dissatisfaction among Sri Lankan female adolescents was confirmed.
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http://dx.doi.org/10.1177/1359105316637665DOI Listing
December 2017

Biological activities of unique isoflavones prepared from Apios americana Medik.

Biosci Biotechnol Biochem 2016 25;80(4):774-8. Epub 2016 Jan 25.

a Department of Food and Nutrition , Japan Women's University , Tokyo , Japan.

Four unique isoflavone aglycones (barpisoflavone A (1), 2'-hydroxygenistein (2), 5-methylgenistein (3), and gerontoisoflavone A (4)) whose structures were related to genistein were prepared from the tuber of Apios americana Medik. We examined the estrogen receptor and androgen receptor binding activities, estrogen agonistic activities, antioxidant activities, and α-glucosidase inhibitory activities of 1-4. The results obtained showed that 2 possessed potent and 1, 3, and 4 possessed moderate estrogen partial agonistic activities, 1 and 2 possessed moderate antioxidant activities, and 2 and 3 possessed moderate α-glucosidase inhibitory activities.
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http://dx.doi.org/10.1080/09168451.2015.1127132DOI Listing
December 2016

Characteristic changes of saliva and taste in burning mouth syndrome patients.

J Oral Pathol Med 2016 Mar 21;45(3):231-6. Epub 2015 Aug 21.

Department of Basic Oral Health Engineering, Track of Medical and Dental Science and Technology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Background: Burning mouth syndrome (BMS) is characterized by chronic pain with a burning sensation of the tongue and oral mucosa and reported to be often accompanied by subjective xerostomia and dysgeusia. Since the etiology of BMS has not been elucidated, to understand the characteristics of BMS, we measured some components of saliva and taste sensitivity and compared the measured values between BMS and healthy subjects.

Methods: Unstimulated saliva was collected from 15 female BMS patients and 30 healthy women. The flow rate, viscosity (spinnability) and concentration of secretory IgA (SIgA) of saliva and serum antioxidant capacity were measured. The recognition thresholds for sweet, salty, sour, bitter, and umami tastes were measured by whole-mouth method. The statistical analyses were performed using Student's t-test, and P < 0.05 was considered to be significant.

Results: In BMS group, the flow rate of saliva was significantly lower and the spinnability was significantly higher compared with healthy group. The secreted amount of SIgA per min and serum antioxidant capacity was significantly lower in the patients. The threshold for sourness in patients was significantly higher, while those for other tastes did not differ from healthy group.

Conclusions: BMS patients showed lower salivary flow and higher salivary spinnability. These results together with decreased SIgA amount, suggest that BMS may be relevant to the deterioration of salivary condition, which could in turn affect taste function. Furthermore, the lower antioxidant capacity in patient's serum suggests that it can serve as a diagnostic tool for BMS.
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http://dx.doi.org/10.1111/jop.12350DOI Listing
March 2016

The relationship between mothers' thin-ideal and children's drive for thinness: A survey of Japanese early adolescents and their mothers.

J Health Psychol 2016 Jan 6;21(1):100-11. Epub 2014 Mar 6.

Ochanomizu University, Japan

We examined the association of mothers' thin-ideal internalization and children's drive for thinness. Early adolescents (175 girls and 198 boys) completed a questionnaire to assess their drive for thinness and perceptions of mothers' attitudes and behaviors related to body shape. The questionnaire for mothers (n = 206) measured mothers' thin-ideal internalization. Mothers' thin-ideal internalization was associated with girls' drive for thinness through the perception of mothers' attitudes directed to girls, and with boys' drive for thinness through mothers' weight-loss behavior. The findings suggest the possibility that mothers transmit social standards on body shape to their children.
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http://dx.doi.org/10.1177/1359105314522676DOI Listing
January 2016

Tetrathiafulvalene-annulated subphthalocyanines.

Chemistry 2013 Jun 23;19(23):7324-7. Epub 2013 Apr 23.

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.

Peripheral expansion: A series of peripherally tetrathiafulvalene (TTF)-annulated subphthalocyanines was synthesized (see scheme). These compounds exhibited unique perturbed optical properties, such as a comparatively broad Q band absorption and gradual quenching of fluorescence upon increasing the number of TTF units, while electrochemical measurements revealed TTF-centered oxidation processes.
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http://dx.doi.org/10.1002/chem.201300709DOI Listing
June 2013

Female families' experiences of caring for persons with schizophrenia.

Arch Psychiatr Nurs 2013 Apr 3;27(2):72-7. Epub 2013 Jan 3.

Psychiatric and Mental Health Nursing, Interdisciplinary Graduate School of Medicine Engineering, University of Yamanashi, Shimokato Chuoshi, Yamanashi, Japan.

The caring experiences of female families of persons with schizophrenia were described through exploring the families' descriptions of their experiences. Focus group interviews were conducted with 11 family caregivers. According to content analysis, the experiences revealed five major themes: early family experiences, family perceptions of illness and relatives with schizophrenia, family burden and suffering, family attitudes toward relatives with schizophrenia, and family thoughts about society and mental health resources. Also, the families had strength to overcome considerable adversity. It is needed for professionals to listen to family caregivers' narratives carefully and improve the support by focusing on accepting their experiences and histories with persons with schizophrenia.
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http://dx.doi.org/10.1016/j.apnu.2012.10.007DOI Listing
April 2013

The effect of alternating current iontophoresis on rats with the chronic constriction injury to the infraorbital nerve.

Int J Dent 2012 23;2012:405292. Epub 2012 May 23.

Department of Orofacial Pain Management, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.

This study aimed to examine the effect of AC iontophoresis on rats with the chronic constriction injury (CCI) to the infraorbital nerve by animal experiments. CCI model rats were divided into four groups, namely, rats that received general anesthesia for 60 min except AC IOP (CCI: n = 5), AC IOP with 0.9% physiological saline for 60 min (CCI + saline AC IOP: n = 5), AC IOP with 4% lidocaine hydrochloride for 60 min (CCI + lidocaine AC IOP: n = 5), and attachment of two electrodes soaked with 4% lidocaine hydrochloride to the facial skin for 60 min (CCI + attach lidocaine: n = 5). In the CCI + lidocaine AC IOP group, an elevated withdrawal threshold was observed after AC IOP, and the duration of efficacy was longer compared with that in the CCI + saline AC IOP and CCI + attached lidocaine groups. A significant decrease in the number of Fos-like immunoreactive (LI) cells was observed in the CCI + lidocaine AC IOP group compared with that in the CCI group. These findings suggest that the effect of CCI + lidocaine AC IOP group may be caused by active permeation of lidocaine into the facial skin and electrical stimulation of the trigeminal nucleus.
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http://dx.doi.org/10.1155/2012/405292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366247PMC
August 2012

Synthesis and properties of β,β-sp3-hybridized subphthalocyanine analogues.

Chem Commun (Camb) 2012 Apr;48(34):4100-2

Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.

A β,β-sp(3)-hybridized subphthalocyanine analogue, dibenzosubtriazachlorin, was synthesized, and its significantly split Q band absorptions in longer and shorter wavelength regions relative to those of subphthalocyanines were revealed. The effect of benzo-annulation to a subtriazachlorin structure on the position of the split Q bands as well as the electronic structures was also investigated.
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http://dx.doi.org/10.1039/c2cc30511aDOI Listing
April 2012

Modulation of paratrigeminal nociceptive neurons following temporomandibular joint inflammation in rats.

Exp Neurol 2008 Dec 22;214(2):209-18. Epub 2008 Aug 22.

Department of Orofacial Pain Management, Tokyo Medical and Dental University, Bunkyo-ku, Yushima, Tokyo 113-8549, Japan.

To evaluate the involvement of paratrigeminal nucleus (Pa5) nociceptive neurons in temporomandibular joint (TMJ) inflammation-induced pain and its autonomic correlates, we conducted behavioral, single unit recording and Fos immunohistochemical studies in anesthetized rats. Nocifensive behaviors to mechanical, heat or cold stimulation of the lateral face over the TMJ region were significantly enhanced in the TMJ-inflamed rats for 10-14 days after injection of complete Freund's adjuvant (CFA) into the TMJ and gradually decreased at the end of the 14-day observation period. Lowering of the nocifensive threshold in TMJ-inflamed rats lasted longer in vagus nerve-transected rats than vagus nerve-intact rats. A large number of Fos-like immunoreactive (LI) cells were observed in the Pa5, and half of them were retrogradely labeled with Fluorogold (FG) injected into the parabrachial nucleus. Background activity of Pa5 wide dynamic range and nociceptive specific neurons was significantly higher in the TMJ-inflamed rats when compared with controls. Responses to mechanical stimuli were significantly higher in NS neurons in the TMJ-inflamed rats. All thermal responsive Pa5 neurons were exclusively sensitive to cold and the response to cold was significantly higher in the TMJ-inflamed rats compared with control rats. Vagus nerve stimulation significantly decreased responses to mechanical and cold stimuli as well as the background activity in TMJ-treated rats but not in TMJ-untreated rats. The present findings suggest that populations of Pa5 neurons are nociceptive and involved in TMJ inflammation-induced pain as well as in autonomic processes related to TMJ pain.
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http://dx.doi.org/10.1016/j.expneurol.2008.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684032PMC
December 2008

[Case of pulmonary aspergillosis associated with inappropriate antidiuretic hormone syndrome caused by voriconazole therapy].

Nihon Kokyuki Gakkai Zasshi 2007 Jun;45(6):489-93

Department of Respiratory Medicine. Toho University Omori Medical Center.

A 75-year-old man presented with hemoptysis. Consolidation was identified in the left lower lobe around multiple bullae. He was found to have chronic necrotizing pulmonary aspergillosis based on a high titer of aspergillus antigen and positive antibody. He was treated with 400 mg/day voriconazole. However, liver dysfunction and hyponatremia developed at 21 days after beginning administration of voriconazole. Serum sodium levels were 122 mEq/l. but urinary sodium showed a high level of 135 mEq/l. The serum sodium level improved 10 days after voriconazole was discontinued. Serum levels of voriconazole on day 15 were high at 18 microg/ml (safe effective serum level: 1.5 to 4.5 microg/ml). An analysis of genetic polymorphism showed a mutation of cytochrome P450 (CYP2C19*2 G681A). We report the first case of a voriconazole-induced syndrome of inappropriate antidiuretic hormone caused by a polymorphism mutation of cytochrome P450.
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June 2007

Establishment of a highly tumorigenic LNCaP cell line having inflammatory cytokine resistance.

Cancer Lett 2006 Oct 27;242(1):46-52. Epub 2005 Dec 27.

Drug Development Unit, Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan.

Human androgen-dependent prostate cancer LNCaP cells are low tumorigenic even in immunodeficient mice and were killed by the synergistic effect of inflammatory cytokines, IL-beta and IL-6. To establish a highly tumorigenic LNCaP cell line, we isolated the cytokine-resistant LNCaP-CR cell line and examined the phenotypes. The parental LNCaP cells were induced to commit apoptosis by the addition of IL-1beta and IL-6, but LNCaP-CR cells showed strong resistance against the cytokine action. However, LNCaP-CR cells did not exhibit any resistance to various antitumor drugs investigated. While LNCaP cells formed only palpable tumors in SCID mice, LNCaP-CR cells readily made tumors and their growth was significantly higher than that of LNCaP cells. Moreover, LNCaP tumor-bearing mice gained the weight gradually, but LNCaP-CR tumor-bearing mice significantly lost their body weight. LNCaP-CR cells still responded to androgen action and expressed AR, erbB2, IL-1R, IL-6R, gp130, STAT3, p21, Bcl-2 and caspase-3 as well as LNCaP cells. These results indicate that LNCaP-CR cell line is a new type of tumorigenic LNCaP cell lines and should be useful for identifying responsible genes of tumorigenicity, cytokine resistance, and also cachexia.
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http://dx.doi.org/10.1016/j.canlet.2005.10.040DOI Listing
October 2006

Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats.

Pain 2004 Oct;111(3):323-334

Department of Physiology, School of Dentistry, Nihon University, Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1-9-20, Fujimi-cho, Chiyoda-ku, Tokyo 102-8159, Japan Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Tokyo 101-8310, Japan Department of Dysphagia Rehabilitation, Nihon University School of Dentistry, Tokyo 101-8310, Japan Department of Dental Anesthesiology, Nihon University School of Dentistry, Tokyo 101-8310, Japan Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, MD 21201, USA Division of Applied System Neuroscience Advanced Medical Research Center, Nihon University Graduate School of Medical Science, 30-1 Ohyaguchi-Kamimachi Itabashi, Tokyo 173-8610, Japan.

After transection of the inferior alveolar nerve (IAN), the whisker pad area, which is innervated by the infraorbital nerve (ION) that was not injured, showed hypersensitivity to mechanical stimulation. Two days after IAN transection, threshold intensity for escape behavior to mechanical stimulation of the ipsilateral whisker pad area was less than 4.0 g, indicating mechanical allodynia. A total of 68 single fiber discharges were recorded from ION fibers at 3 days after IAN transection. The responses of C- and A-fibers were classified according to their conduction velocity. The C-fiber activities were not affected by IAN transection, whereas A-fiber activities were significantly enhanced by IAN transection as indicated by an increase in background activity and mechanically evoked response. Since the A-fiber responses were significantly affected by IAN transection, patch clamp recording was performed from middle to large diameter retrogradely labeled and acutely dissociated trigeminal ganglion (TRG) neurons. The I(K) (sustained) and I(A) (transient) currents were significantly smaller and hyperpolarization-activated current (I(h)) was significantly larger in TRG neurons of rats with IAN transection as compared to those of naive rats. Furthermore, current injection into TRG neurons induced high frequency spike discharges in rats with IAN transection. These data suggest that changes in K(+) current and I(h) observed in the uninjured TRG neurons reflect an increase in excitability of TRG neurons innervated by the ION after IAN transection, resulting in the development of mechano-allodynia in the area adjacent to the injured IAN innervated region.
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http://dx.doi.org/10.1016/j.pain.2004.07.014DOI Listing
October 2004

Specific inhibition of hypoxia-inducible factor (HIF)-1 alpha activation and of vascular endothelial growth factor (VEGF) production by flavonoids.

Biol Pharm Bull 2003 Oct;26(10):1379-83

Department of Microbiology, Showa University of Pharmaceutical Sciences, Tokyo, Japan.

Screening using a reporter under the control of the hypoxia-response element (HRE) identified several flavonoids and homoisoflavonoids that inhibit the activation of HRE under hypoxic conditions. Among various compounds, isorhamnetin, luteolin, quercetin, and methyl ophiopogonanone B (MOB) were effective at 3 to 9 microg/ml in inhibiting the reporter activity. The expression of vascular endothelial growth factor (VEGF) mRNA during hypoxia was also inhibited by MOB in HepG2 cells, but the effective doses were 10 to 20 microg/ml. MOB caused destabilization of hypoxia-inducible factor (HIF)-1alpha, as revealed by Western blotting, that was dependent on proteasome activity and the tumor suppressor, p53. The tubular formation and migration of human umbilical vein endothelial cells was also inhibited by MOB. MOB is expected to act as an inhibitor of angiogenesis.
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http://dx.doi.org/10.1248/bpb.26.1379DOI Listing
October 2003

Modulation of neutrophil adhesion to vascular endothelial cells in rat experimental otitis media treated with a macrolide.

Auris Nasus Larynx 2003 Aug;30(3):247-51

Department of Otorhinolaryngology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyu-ku, Tokyo 113-8421, Japan.

Object: We previously reported that erythromycin (EM) affected the adhesion molecules that interact with neutrophils and inhibited neutrophil infiltration in a rat experimental otitis media model.

Purpose: The purpose of the present study was to examine whether EM affects the adhesion of rat neutrophils to endothelial cells.

Methods: The adhesion of neutrophils to WK-5 endothelial cells was evaluated. One group of rats was given EM for 2 weeks, while the other group received no treatment. The adhesion of peripheral-blood neutrophils and neutrophils accumulated in the middle ear from these two groups were compared.

Results: Two-week EM pretreatment inhibited adhesion of neutrophils to WK-5 cells. The adhesion of neutrophils accumulated in the middle ear cavity to WK-5 cells was significantly higher than that of peripheral-blood neutrophils from control rats.

Conclusion: The results suggest that EM affects the adhesion of neutrophils to endothelial cells.
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http://dx.doi.org/10.1016/s0385-8146(03)00097-xDOI Listing
August 2003

[Intravenous anesthesia using continuous administration of propofol and fentanyl: fentanyl administration procedure and quality of awareness].

Masui 2003 Jun;52(6):626-30

Department of Dental Anesthesiology, Nihon University School of Dentistry, Tokyo 101-8310.

Background: We studied total intravenous anesthesia using continuous administration of propofol and fentanyl and examined especially the method of fetanyl administration.

Methods: Anesthesia was induced with fentanyl 2 micrograms.kg-1 and propofol 2 mg.kg-1. Fentanyl 1 microgram.kg-1 was then administered before the start of the operation and infused continuously at a rate of 0.02 microgram.kg-1.min-1 during operation. Propofol was also infused continuously at 4-10 mg.kg-1.min-1.

Results: These methods allowed a significant reduction in the necessary dose of fentanyl and propofol compared with ordinary methods, and a stable general condition was maintained during the operation. Additionally, high quality of awareness was obtained after the recovery.

Conclusions: This continuous administration procedure of fentanyl reduced the total doses of both propofol and fentanyl, allowing high quality of awareness after the recovery.
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June 2003
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