Yoichi Furukawa

Yoichi Furukawa

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Yoichi Furukawa

Publications by authors named "Yoichi Furukawa"

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Importance of gastric cancer for the diagnosis and surveillance of Japanese Lynch syndrome patients.

J Hum Genet 2019 Oct 7. Epub 2019 Oct 7.

Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

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http://www.nature.com/articles/s10038-019-0674-5
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http://dx.doi.org/10.1038/s10038-019-0674-5DOI Listing
October 2019

Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient.

J Hum Genet 2019 Aug 14;64(8):729-740. Epub 2019 May 14.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, Japan.

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http://dx.doi.org/10.1038/s10038-019-0611-7DOI Listing
August 2019

Characterization of human UGT2A3 expression using a prepared specific antibody against UGT2A3.

Drug Metab Pharmacokinet 2019 Aug 13;34(4):280-286. Epub 2019 May 13.

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan; WPI Nano Life Science Institute, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.dmpk.2019.05.001DOI Listing
August 2019

Anti-apoptotic effect by the suppression of IRF1 as a downstream of Wnt/β-catenin signaling in colorectal cancer cells.

Oncogene 2019 Aug 10;38(32):6051-6064. Epub 2019 Jul 10.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, the University of Tokyo, Tokyo, 108-8639, Japan.

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http://dx.doi.org/10.1038/s41388-019-0856-9DOI Listing
August 2019

Quantitative Analysis of UDP-Glucuronosyltransferase Ugt1a and Ugt2b mRNA Expression in the Rat Liver and Small Intestine: Sex and Strain Differences.

Drug Metab Dispos 2019 01 2;47(1):38-44. Epub 2018 Nov 2.

Drug Metabolism and Toxicology, Faculty of Pharmaceutical Sciences (T.K., Y.F., K.O., S.G., T.F., M.N.), and WPI Nano Life Science Institute (T.F., M.N.), Kanazawa University, Kakuma-machi, Kanazawa, Japan

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http://dx.doi.org/10.1124/dmd.118.083287DOI Listing
January 2019

Implementation of genomic medicine for gastrointestinal tumors.

Authors:
Yoichi Furukawa

Ann Gastroenterol Surg 2018 Jul 8;2(4):246-252. Epub 2018 Jun 8.

Division of Clinical Genome Research The Institute of Medical Science The University of Tokyo Tokyo Japan.

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http://dx.doi.org/10.1002/ags3.12178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6036382PMC
July 2018

Bidirectional reporter assay using HAL promoter and TOPFLASH improves specificity in high-throughput screening of Wnt inhibitors.

Biotechnol Bioeng 2017 12 29;114(12):2868-2882. Epub 2017 Aug 29.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1002/bit.26394
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http://dx.doi.org/10.1002/bit.26394DOI Listing
December 2017

Decreased expression of interferon-induced protein 2 (IFIT2) by Wnt/β-catenin signaling confers anti-apoptotic properties to colorectal cancer cells.

Oncotarget 2017 Nov 26;8(59):100176-100186. Epub 2017 Oct 26.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.18632/oncotarget.22122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5725011PMC
November 2017

Genetic alterations in Japanese extrahepatic biliary tract cancer.

Oncol Lett 2017 Jul 22;14(1):877-884. Epub 2017 May 22.

Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.3892/ol.2017.6224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5494721PMC
July 2017

Identification of FERM domain-containing protein 5 as a novel target of β-catenin/TCF7L2 complex.

Cancer Sci 2017 Apr 20;108(4):612-619. Epub 2017 Apr 20.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1111/cas.13174
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http://dx.doi.org/10.1111/cas.13174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406541PMC
April 2017

Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases.

J Epidemiol 2017 Mar 9;27(3S):S9-S21. Epub 2017 Feb 9.

Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.je.2016.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363792PMC
March 2017

Overview of BioBank Japan follow-up data in 32 diseases.

J Epidemiol 2017 Mar 10;27(3S):S22-S28. Epub 2017 Feb 10.

Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.je.2016.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363789PMC
March 2017

[NEW ERA OF PERSONALIZED MEDICINE THROUGH NEXT-GENERATION SEQUENCING].

Authors:
Yoichi Furukawa

Nihon Geka Gakkai Zasshi 2016 Nov;117(6):530-5

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November 2016

Smyd5 plays pivotal roles in both primitive and definitive hematopoiesis during zebrafish embryogenesis.

Sci Rep 2016 07 5;6:29157. Epub 2016 Jul 5.

Division of Molecular and Developmental Biology, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/srep29157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932602PMC
July 2016

Reduced expression of APC-1B but not APC-1A by the deletion of promoter 1B is responsible for familial adenomatous polyposis.

Sci Rep 2016 05 24;6:26011. Epub 2016 May 24.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/srep26011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877598PMC
May 2016

Attenuated familial adenomatous polyposis with desmoids caused by an APC mutation.

Hum Genome Var 2015 26;2:15011. Epub 2015 Mar 26.

Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo , Tokyo, Japan.

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http://dx.doi.org/10.1038/hgv.2015.11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4785566PMC
April 2016

Oncolytic Activity of a Recombinant Measles Virus, Blind to Signaling Lymphocyte Activation Molecule, Against Colorectal Cancer Cells.

Sci Rep 2016 Apr 19;6:24572. Epub 2016 Apr 19.

Laboratory Animal Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/srep24572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835780PMC
April 2016

Molecular profiles of high-grade and low-grade pseudomyxoma peritonei.

Cancer Med 2015 Dec 16;4(12):1809-16. Epub 2015 Oct 16.

Division of Clinical Genome Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://doi.wiley.com/10.1002/cam4.542
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http://dx.doi.org/10.1002/cam4.542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123786PMC
December 2015

Detection of APC mosaicism by next-generation sequencing in an FAP patient.

J Hum Genet 2015 May 26;60(5):227-31. Epub 2015 Feb 26.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/jhg.2015.14DOI Listing
May 2015

Identification of two Wnt-responsive elements in the intron of RING finger protein 43 (RNF43) gene.

PLoS One 2014 22;9(1):e86582. Epub 2014 Jan 22.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0086582PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899290PMC
November 2014

Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics.

Mol Endocrinol 2014 Oct 22;28(10):1740-51. Epub 2014 Aug 22.

Division of Clinical Pharmacology (M.L., L.W., R.M.W.), Department of Molecular Pharmacology and Experimental Therapeutics; Departments of Oncology (J.N.I.) and Health Sciences Research (A.B., G.D.J., E.E.C., D.J.S.); and Division of Endocrinology (S.K.), Mayo Clinic, Rochester, Minnesota 55905; Massachusetts General Hospital (P.E.G.), Harvard University, Boston, Massachusetts 02114; Rikagaku Kenkyūsho Center for Integrative Medical Science (M.K., Y.F.), Yokohama, Japan 230-0045; School of Medicine (Y.N.), Chicago University, Chicago, Illinois 60637; National Cancer Institute of Canada Clinical Trials Group (J.-A.W.C., L.E.S.), Kingston, Ontario, Canada K7L 3N6; and Division of Oncology (M.J.E.), Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110.

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http://dx.doi.org/10.1210/me.2014-1147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4179631PMC
October 2014

Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity.

Neoplasia 2014 Aug;16(8):656-64

Section of Hematology/Oncology, Department of Medicine, The University of Chicago, Chicago, IL 60637 USA. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2014.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234875PMC
August 2014

Aberrant splicing caused by a MLH1 splice donor site mutation found in a young Japanese patient with Lynch syndrome.

Fam Cancer 2012 Dec;11(4):559-64

Department of Clinical Oncology, Institute of Development, Aging and Cancer, and Tohoku University Hospital, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, Japan.

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http://link.springer.com/10.1007/s10689-012-9547-1
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http://dx.doi.org/10.1007/s10689-012-9547-1DOI Listing
December 2012

CLCA2 as a p53-inducible senescence mediator.

Neoplasia 2012 Feb;14(2):141-9

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3306259PMC
http://dx.doi.org/10.1593/neo.111700DOI Listing
February 2012

Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish.

PLoS One 2011 24;6(8):e23491. Epub 2011 Aug 24.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Japan.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0023491PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160858PMC
January 2012

MRG-binding protein contributes to colorectal cancer development.

Cancer Sci 2011 Aug 9;102(8):1486-92. Epub 2011 Jun 9.

Division of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2011.01971.xDOI Listing
August 2011

[Mechanisms of colorectal carcinogenesis].

Authors:
Yoichi Furukawa

Nihon Rinsho 2011 Apr;69 Suppl 3:108-14

Division of Clinical Genome Research, Institute of Medical Science, The University of Tokyo.

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April 2011

SMYD3 interacts with HTLV-1 Tax and regulates subcellular localization of Tax.

Cancer Sci 2011 Jan 5;102(1):260-6. Epub 2010 Nov 5.

Department of Medical Genome Sciences, Laboratory of Tumor Cell Biology, Graduate School of Frontier Sciences, The University of Tokyo, Minato-ku, Tokyo, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01752.xDOI Listing
January 2011

Deficiency of GMDS leads to escape from NK cell-mediated tumor surveillance through modulation of TRAIL signaling.

Gastroenterology 2009 Jul 8;137(1):188-98, 198.e1-2. Epub 2009 Apr 8.

Department of Molecular Biochemistry and Clinical Investigation, Osaka University Graduate School of Medicine, Osaka, Japan.

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http://dx.doi.org/10.1053/j.gastro.2009.04.002DOI Listing
July 2009

Planning the human variome project: the Spain report.

Authors:
Jim Kaput Richard G H Cotton Lauren Hardman Michael Watson Aida I Al Aqeel Jumana Y Al-Aama Fahd Al-Mulla Santos Alonso Stefan Aretz Arleen D Auerbach Bharati Bapat Inge T Bernstein Jong Bhak Stacey L Bleoo Helmut Blöcker Steven E Brenner John Burn Mariona Bustamante Rita Calzone Anne Cambon-Thomsen Michele Cargill Paola Carrera Lawrence Cavedon Yoon Shin Cho Yeun-Jun Chung Mireille Claustres Garry Cutting Raymond Dalgleish Johan T den Dunnen Carlos Díaz Steven Dobrowolski M Rosário N dos Santos Rosemary Ekong Simon B Flanagan Paul Flicek Yoichi Furukawa Maurizio Genuardi Ho Ghang Maria V Golubenko Marc S Greenblatt Ada Hamosh John M Hancock Ross Hardison Terence M Harrison Robert Hoffmann Rania Horaitis Heather J Howard Carol Isaacson Barash Neskuts Izagirre Jongsun Jung Toshio Kojima Sandrine Laradi Yeon-Su Lee Jong-Young Lee Vera L Gil-da-Silva-Lopes Finlay A Macrae Donna Maglott Makia J Marafie Steven G E Marsh Yoichi Matsubara Ludwine M Messiaen Gabriela Möslein Mihai G Netea Melissa L Norton Peter J Oefner William S Oetting James C O'Leary Ana Maria Oller de Ramirez Mark H Paalman Jillian Parboosingh George P Patrinos Giuditta Perozzi Ian R Phillips Sue Povey Suyash Prasad Ming Qi David J Quin Rajkumar S Ramesar C Sue Richards Judith Savige Dagmar G Scheible Rodney J Scott Daniela Seminara Elizabeth A Shephard Rolf H Sijmons Timothy D Smith María-Jesús Sobrido Toshihiro Tanaka Sean V Tavtigian Graham R Taylor Jon Teague Thoralf Töpel Mollie Ullman-Cullere Joji Utsunomiya Henk J van Kranen Mauno Vihinen Elizabeth Webb Thomas K Weber Meredith Yeager Young I Yeom Seon-Hee Yim Hyang-Sook Yoo

Hum Mutat 2009 Apr;30(4):496-510

Division of Personalised Nutrition and Medicine, FDA/National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.

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http://compbio.berkeley.edu/people/brenner/pubs/kaput-2009-h
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http://doi.wiley.com/10.1002/humu.20972
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http://dx.doi.org/10.1002/humu.20972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879779PMC
April 2009

Enhanced expression of RAD51 associating protein-1 is involved in the growth of intrahepatic cholangiocarcinoma cells.

Clin Cancer Res 2008 Mar;14(5):1333-9

Laboratory of Molecular Medicine, Human Genome Center and Division of Clinical Genome Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-07-1381DOI Listing
March 2008

The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.

Cancer Res 2007 Nov;67(22):10759-65

Laboratory of Molecular Medicine, Human Genome Center, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1132DOI Listing
November 2007

Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma.

Clin Cancer Res 2006 Nov;12(22):6611-6

Laboratory of Molecular Medicine and Promotion of Genome-Based Medicine Project, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-0783DOI Listing
November 2006

Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma.

Hepatology 2006 Oct;44(4):1025-38

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan.

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http://dx.doi.org/10.1002/hep.21330DOI Listing
October 2006

A gene encoding a family with sequence similarity 84, member A (FAM84A) enhanced migration of human colon cancer cells.

Int J Oncol 2006 Aug;29(2):341-7

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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August 2006

Identification of TOMM34, which shows elevated expression in the majority of human colon cancers, as a novel drug target.

Int J Oncol 2006 Aug;29(2):381-6

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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August 2006

Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray.

Cancer Sci 2006 May;97(5):411-9

Department of Surgery and Bioengineering, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2006.00194.xDOI Listing
May 2006

Enhanced SMYD3 expression is essential for the growth of breast cancer cells.

Cancer Sci 2006 Feb;97(2):113-8

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2006.00146.xDOI Listing
February 2006

Overexpression of peptidyl-prolyl isomerase-like 1 is associated with the growth of colon cancer cells.

Clin Cancer Res 2006 Jan;12(1):70-6

Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-05-0588DOI Listing
January 2006

Identification of SP5 as a downstream gene of the beta-catenin/Tcf pathway and its enhanced expression in human colon cancer.

Int J Oncol 2005 Dec;27(6):1483-7

Laboratory of Molecular Medicine, The University of Tokyo, Minato-ku, Tokyo, Japan.

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December 2005

A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.

Nat Genet 2005 Oct 11;37(10):1104-7. Epub 2005 Sep 11.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.

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http://dx.doi.org/10.1038/ng1638DOI Listing
October 2005

Up-regulation of PSF2, a member of the GINS multiprotein complex, in intrahepatic cholangiocarcinoma.

Oncol Rep 2005 Sep;14(3):701-6

Laboratory of Molecular Medicine, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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September 2005

Identification of immunoglobulin superfamily 11 (IGSF11) as a novel target for cancer immunotherapy of gastrointestinal and hepatocellular carcinomas.

Cancer Sci 2005 Aug;96(8):498-506

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://doi.wiley.com/10.1111/j.1349-7006.2005.00073.x
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http://dx.doi.org/10.1111/j.1349-7006.2005.00073.xDOI Listing
August 2005

Genome-wide analysis of gene expression in human intrahepatic cholangiocarcinoma.

Hepatology 2005 Jun;41(6):1339-48

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1002/hep.20718DOI Listing
June 2005

WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation.

Neoplasia 2005 Apr;7(4):348-55

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1501145PMC
http://dx.doi.org/10.1593/neo.04544DOI Listing
April 2005

Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer.

Oncogene 2004 Dec;23(57):9289-94

1Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/sj.onc.1208100DOI Listing
December 2004

Ring finger protein 43 as a new target for cancer immunotherapy.

Clin Cancer Res 2004 Dec;10(24):8577-86

Department of Surgery and Bioengineering, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1158/1078-0432.CCR-04-0104DOI Listing
December 2004

DKK1, a negative regulator of Wnt signaling, is a target of the beta-catenin/TCF pathway.

Oncogene 2004 Nov;23(52):8520-6

Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

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http://dx.doi.org/10.1038/sj.onc.1207892DOI Listing
November 2004

A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer.

Int J Oncol 2004 Nov;25(5):1343-8

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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November 2004

Comparison of gene-expression profiles between diffuse- and intestinal-type gastric cancers using a genome-wide cDNA microarray.

Oncogene 2004 Sep;23(40):6830-44

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

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http://dx.doi.org/10.1038/sj.onc.1207886DOI Listing
September 2004

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.

Nat Cell Biol 2004 Aug 4;6(8):731-40. Epub 2004 Jul 4.

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/ncb1151DOI Listing
August 2004

Isolation of LEM domain-containing 1, a novel testis-specific gene expressed in colorectal cancers.

Oncol Rep 2004 Aug;12(2):275-80

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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August 2004

Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer.

Cancer Sci 2004 May;95(5):430-5

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2004.tb03227.xDOI Listing
May 2004

Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells.

J Biol Chem 2004 Feb 1;279(8):6840-6. Epub 2003 Dec 1.

Laboratory of Molecular and Genetic Information, Institute of Molecular and Cellular Biosciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

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http://dx.doi.org/10.1074/jbc.M310876200DOI Listing
February 2004

Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray.

Int J Oncol 2004 Feb;24(2):305-12

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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February 2004

Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas.

Int J Oncol 2004 Jan;24(1):43-8

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo 108-8639, Japan.

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January 2004

Involvement of the FGF18 gene in colorectal carcinogenesis, as a novel downstream target of the beta-catenin/T-cell factor complex.

Cancer Res 2003 Oct;63(19):6116-20

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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October 2003

Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1.

Cancer Res 2003 Jun;63(12):3043-8

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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June 2003

Genome-wide analysis of gene expression in intestinal-type gastric cancers using a complementary DNA microarray representing 23,040 genes.

Cancer Res 2002 Dec;62(23):7012-7

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.

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December 2002

Isolation of a novel human gene, APCDD1, as a direct target of the beta-Catenin/T-cell factor 4 complex with probable involvement in colorectal carcinogenesis.

Cancer Res 2002 Oct;62(20):5651-6

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Japan.

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October 2002

Isolation of HELAD1, a novel human helicase gene up-regulated in colorectal carcinomas.

Oncogene 2002 Sep;21(41):6387-94

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/sj.onc.1205751DOI Listing
September 2002

Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers.

Oncogene 2002 Aug;21(38):5861-7

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan.

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http://dx.doi.org/10.1038/sj.onc.1205755DOI Listing
August 2002

Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma.

Int J Oncol 2002 Jun;20(6):1173-8

Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Shirokanedai, Minato-ku 108-8639, Japan.

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June 2002

Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas.

Oncogene 2002 Jun;21(26):4120-8

Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

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http://dx.doi.org/10.1038/sj.onc.1205518DOI Listing
June 2002