Yohan Bossé

Yohan Bossé

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Yohan Bossé

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Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 Jun;51(6):1067

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-019-0438-3DOI Listing
June 2019

Activated platelets promote an osteogenic programme and the progression of calcific aortic valve stenosis.

Eur Heart J 2019 May;40(17):1362-1373

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, 2725 chemin Ste-Foy, Quebec, Canada.

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http://dx.doi.org/10.1093/eurheartj/ehy696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492053PMC
May 2019

Benefits and limitations of genome-wide association studies.

Nat Rev Genet 2019 May 8. Epub 2019 May 8.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/s41576-019-0127-1DOI Listing
May 2019

UCP1 expression-associated gene signatures of human epicardial adipose tissue.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Medicine, Faculty of Medicine, Université Laval, Québec, Québec, Canada.

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https://insight.jci.org/articles/view/123618
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http://dx.doi.org/10.1172/jci.insight.123618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6538324PMC
April 2019

PALMD as a novel target for calcific aortic valve stenosis.

Curr Opin Cardiol 2019 Mar;34(2):105-111

Institut Universitaire de Cardiologie et de Pneumologie de Québec.

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http://dx.doi.org/10.1097/HCO.0000000000000605DOI Listing
March 2019

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Authors:
Nick Shrine Anna L Guyatt A Mesut Erzurumluoglu Victoria E Jackson Brian D Hobbs Carl A Melbourne Chiara Batini Katherine A Fawcett Kijoung Song Phuwanat Sakornsakolpat Xingnan Li Ruth Boxall Nicola F Reeve Ma'en Obeidat Jing Hua Zhao Matthias Wielscher Stefan Weiss Katherine A Kentistou James P Cook Benjamin B Sun Jian Zhou Jennie Hui Stefan Karrasch Medea Imboden Sarah E Harris Jonathan Marten Stefan Enroth Shona M Kerr Ida Surakka Veronique Vitart Terho Lehtimäki Richard J Allen Per S Bakke Terri H Beaty Eugene R Bleecker Yohan Bossé Corry-Anke Brandsma Zhengming Chen James D Crapo John Danesh Dawn L DeMeo Frank Dudbridge Ralf Ewert Christian Gieger Amund Gulsvik Anna L Hansell Ke Hao Joshua D Hoffman John E Hokanson Georg Homuth Peter K Joshi Philippe Joubert Claudia Langenberg Xuan Li Liming Li Kuang Lin Lars Lind Nicholas Locantore Jian'an Luan Anubha Mahajan Joseph C Maranville Alison Murray David C Nickle Richard Packer Margaret M Parker Megan L Paynton David J Porteous Dmitry Prokopenko Dandi Qiao Rajesh Rawal Heiko Runz Ian Sayers Don D Sin Blair H Smith María Soler Artigas David Sparrow Ruth Tal-Singer Paul R H J Timmers Maarten Van den Berge John C Whittaker Prescott G Woodruff Laura M Yerges-Armstrong Olga G Troyanskaya Olli T Raitakari Mika Kähönen Ozren Polašek Ulf Gyllensten Igor Rudan Ian J Deary Nicole M Probst-Hensch Holger Schulz Alan L James James F Wilson Beate Stubbe Eleftheria Zeggini Marjo-Riitta Jarvelin Nick Wareham Edwin K Silverman Caroline Hayward Andrew P Morris Adam S Butterworth Robert A Scott Robin G Walters Deborah A Meyers Michael H Cho David P Strachan Ian P Hall Martin D Tobin Louise V Wain

Nat Genet 2019 03 25;51(3):481-493. Epub 2019 Feb 25.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/s41588-018-0321-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397078PMC
March 2019

Genetic interaction analysis among oncogenesis-related genes revealed novel genes and networks in lung cancer development.

Oncotarget 2019 Mar 5;10(19):1760-1774. Epub 2019 Mar 5.

Biomedical Data Science Department, Dartmouth College, Hanover, NH, USA.

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http://dx.doi.org/10.18632/oncotarget.26678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442994PMC
March 2019

Soluble CD14 is associated with the structural failure of bioprostheses.

Clin Chim Acta 2018 Oct 30;485:173-177. Epub 2018 Jun 30.

Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2018.06.045DOI Listing
October 2018

GATA6 Regulates Aortic Valve Remodeling, and Its Haploinsufficiency Leads to Right-Left Type Bicuspid Aortic Valve.

Circulation 2018 Sep;138(10):1025-1038

Department of Biochemistry, Microbiology, and Immunology, Molecular Genetics and Cardiac Regeneration Laboratory, University of Ottawa, Ontario, Canada (L.G., H.K., R.H., M.T., M.N.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151169PMC
September 2018

Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.

Authors:
Xuemei Ji Yohan Bossé Maria Teresa Landi Jiang Gui Xiangjun Xiao David Qian Philippe Joubert Maxime Lamontagne Yafang Li Ivan Gorlov Mariella de Biasi Younghun Han Olga Gorlova Rayjean J Hung Xifeng Wu James McKay Xuchen Zong Robert Carreras-Torres David C Christiani Neil Caporaso Mattias Johansson Geoffrey Liu Stig E Bojesen Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert Chu Chen M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier A Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher Haiman Lynne Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Erik H F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer Doherty Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske Judith Manz Thomas Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard Houlston John McLaughlin Victoria Stevens David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song María Soler Artigas Martin D Tobin Louise V Wain Fangyi Gu Jinyoung Byun Ahsan Kamal Dakai Zhu Rachel F Tyndale Wei-Qi Wei Stephen Chanock Paul Brennan Christopher I Amos

Nat Commun 2018 08 13;9(1):3221. Epub 2018 Aug 13.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, 03750, NH, USA.

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http://dx.doi.org/10.1038/s41467-018-05074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089967PMC
August 2018

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Authors:
Annah B Wyss Tamar Sofer Mi Kyeong Lee Natalie Terzikhan Jennifer N Nguyen Lies Lahousse Jeanne C Latourelle Albert Vernon Smith Traci M Bartz Mary F Feitosa Wei Gao Tarunveer S Ahluwalia Wenbo Tang Christopher Oldmeadow Qing Duan Kim de Jong Mary K Wojczynski Xin-Qun Wang Raymond Noordam Fernando Pires Hartwig Victoria E Jackson Tianyuan Wang Ma'en Obeidat Brian D Hobbs Tianxiao Huan Hongsheng Gui Margaret M Parker Donglei Hu Lauren S Mogil Gleb Kichaev Jianping Jin Mariaelisa Graff Tamara B Harris Ravi Kalhan Susan R Heckbert Lavinia Paternoster Kristin M Burkart Yongmei Liu Elizabeth G Holliday James G Wilson Judith M Vonk Jason L Sanders R Graham Barr Renée de Mutsert Ana Maria Baptista Menezes Hieab H H Adams Maarten van den Berge Roby Joehanes Albert M Levin Jennifer Liberto Lenore J Launer Alanna C Morrison Colleen M Sitlani Juan C Celedón Stephen B Kritchevsky Rodney J Scott Kaare Christensen Jerome I Rotter Tobias N Bonten Fernando César Wehrmeister Yohan Bossé Shujie Xiao Sam Oh Nora Franceschini Jennifer A Brody Robert C Kaplan Kurt Lohman Mark McEvoy Michael A Province Frits R Rosendaal Kent D Taylor David C Nickle L Keoki Williams Esteban G Burchard Heather E Wheeler Don D Sin Vilmundur Gudnason Kari E North Myriam Fornage Bruce M Psaty Richard H Myers George O'Connor Torben Hansen Cathy C Laurie Patricia A Cassano Joohon Sung Woo Jin Kim John R Attia Leslie Lange H Marike Boezen Bharat Thyagarajan Stephen S Rich Dennis O Mook-Kanamori Bernardo Lessa Horta André G Uitterlinden Hae Kyung Im Michael H Cho Guy G Brusselle Sina A Gharib Josée Dupuis Ani Manichaikul Stephanie J London

Nat Commun 2018 07 30;9(1):2976. Epub 2018 Jul 30.

Epidemiology Branch National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1038/s41467-018-05369-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065313PMC
July 2018

Identification of Drug Candidates to Suppress Cigarette Smoke-induced Inflammation via Connectivity Map Analyses.

Am J Respir Cell Mol Biol 2018 Jun;58(6):727-735

1 Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre.

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http://dx.doi.org/10.1165/rcmb.2017-0202OCDOI Listing
June 2018

A Decade of GWAS Results in Lung Cancer.

Cancer Epidemiol Biomarkers Prev 2018 04 14;27(4):363-379. Epub 2017 Jun 14.

Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464125PMC
April 2018

Integrative genomics identifies new genes associated with severe COPD and emphysema.

Respir Res 2018 03 22;19(1):46. Epub 2018 Mar 22.

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Room 451, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-018-0744-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863845PMC
March 2018

Clinical Experience with SERPINA1 DNA Sequencing to Detect Alpha-1 Antitrypsin Deficiency.

Ann Am Thorac Soc 2018 02;15(2):266-268

1 Université Laval Quebec City, Quebec, Canada.

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http://dx.doi.org/10.1513/AnnalsATS.201708-694RLDOI Listing
February 2018

Meta-analysis of exome array data identifies six novel genetic loci for lung function.

Authors:
Victoria E Jackson Jeanne C Latourelle Louise V Wain Albert V Smith Megan L Grove Traci M Bartz Ma'en Obeidat Michael A Province Wei Gao Beenish Qaiser David J Porteous Patricia A Cassano Tarunveer S Ahluwalia Niels Grarup Jin Li Elisabeth Altmaier Jonathan Marten Sarah E Harris Ani Manichaikul Tess D Pottinger Ruifang Li-Gao Allan Lind-Thomsen Anubha Mahajan Lies Lahousse Medea Imboden Alexander Teumer Bram Prins Leo-Pekka Lyytikäinen Gudny Eiriksdottir Nora Franceschini Colleen M Sitlani Jennifer A Brody Yohan Bossé Wim Timens Aldi Kraja Anu Loukola Wenbo Tang Yongmei Liu Jette Bork-Jensen Johanne M Justesen Allan Linneberg Leslie A Lange Rajesh Rawal Stefan Karrasch Jennifer E Huffman Blair H Smith Gail Davies Kristin M Burkart Josyf C Mychaleckyj Tobias N Bonten Stefan Enroth Lars Lind Guy G Brusselle Ashish Kumar Beate Stubbe Mika Kähönen Annah B Wyss Bruce M Psaty Susan R Heckbert Ke Hao Taina Rantanen Stephen B Kritchevsky Kurt Lohman Tea Skaaby Charlotta Pisinger Torben Hansen Holger Schulz Ozren Polasek Archie Campbell John M Starr Stephen S Rich Dennis O Mook-Kanamori Åsa Johansson Erik Ingelsson André G Uitterlinden Stefan Weiss Olli T Raitakari Vilmundur Gudnason Kari E North Sina A Gharib Don D Sin Kent D Taylor George T O'Connor Jaakko Kaprio Tamara B Harris Oluf Pederson Henrik Vestergaard James G Wilson Konstantin Strauch Caroline Hayward Shona Kerr Ian J Deary R Graham Barr Renée de Mutsert Ulf Gyllensten Andrew P Morris M Arfan Ikram Nicole Probst-Hensch Sven Gläser Eleftheria Zeggini Terho Lehtimäki David P Strachan Josée Dupuis Alanna C Morrison Ian P Hall Martin D Tobin Stephanie J London

Wellcome Open Res 2018 12;3. Epub 2018 Jan 12.

Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Dept of Health and Human Services, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.12688/wellcomeopenres.12583.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081985PMC
January 2018

Lung tissue gene-expression signature for the ageing lung in COPD.

Thorax 2017 Dec 6. Epub 2017 Dec 6.

University of Groningen, University Medical Center Groningen, Department of Pathology and Medical Biology, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/thoraxjnl-2017-210074DOI Listing
December 2017

Pathobiology of Lp(a) in calcific aortic valve disease.

Expert Rev Cardiovasc Ther 2017 Oct 24;15(10):797-807. Epub 2017 Aug 24.

d Robarts Research Institute , London , ON , Canada.

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http://dx.doi.org/10.1080/14779072.2017.1367286DOI Listing
October 2017

OxLDL-derived lysophosphatidic acid promotes the progression of aortic valve stenosis through a LPAR1-RhoA-NF-κB pathway.

Cardiovasc Res 2017 Sep;113(11):1351-1363

Laboratory of Cardiovascular Pathobiology, Institut Universitaire de Cardiologie et de Pneumologie de Québec/Quebec Heart and Lung Institute, Research Center, Department of Surgery, Laval University, 2725 Chemin Ste-Foy, Quebec, Quebec G1V-4G5, Canada.

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http://dx.doi.org/10.1093/cvr/cvx089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852522PMC
September 2017

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Authors:
James D McKay Rayjean J Hung Younghun Han Xuchen Zong Robert Carreras-Torres David C Christiani Neil E Caporaso Mattias Johansson Xiangjun Xiao Yafang Li Jinyoung Byun Alison Dunning Karen A Pooley David C Qian Xuemei Ji Geoffrey Liu Maria N Timofeeva Stig E Bojesen Xifeng Wu Loic Le Marchand Demetrios Albanes Heike Bickeböller Melinda C Aldrich William S Bush Adonina Tardon Gad Rennert M Dawn Teare John K Field Lambertus A Kiemeney Philip Lazarus Aage Haugen Stephen Lam Matthew B Schabath Angeline S Andrew Hongbing Shen Yun-Chul Hong Jian-Min Yuan Pier Alberto Bertazzi Angela C Pesatori Yuanqing Ye Nancy Diao Li Su Ruyang Zhang Yonathan Brhane Natasha Leighl Jakob S Johansen Anders Mellemgaard Walid Saliba Christopher A Haiman Lynne R Wilkens Ana Fernandez-Somoano Guillermo Fernandez-Tardon Henricus F M van der Heijden Jin Hee Kim Juncheng Dai Zhibin Hu Michael P A Davies Michael W Marcus Hans Brunnström Jonas Manjer Olle Melander David C Muller Kim Overvad Antonia Trichopoulou Rosario Tumino Jennifer A Doherty Matt P Barnett Chu Chen Gary E Goodman Angela Cox Fiona Taylor Penella Woll Irene Brüske H-Erich Wichmann Judith Manz Thomas R Muley Angela Risch Albert Rosenberger Kjell Grankvist Mikael Johansson Frances A Shepherd Ming-Sound Tsao Susanne M Arnold Eric B Haura Ciprian Bolca Ivana Holcatova Vladimir Janout Milica Kontic Jolanta Lissowska Anush Mukeria Simona Ognjanovic Tadeusz M Orlowski Ghislaine Scelo Beata Swiatkowska David Zaridze Per Bakke Vidar Skaug Shanbeh Zienolddiny Eric J Duell Lesley M Butler Woon-Puay Koh Yu-Tang Gao Richard S Houlston John McLaughlin Victoria L Stevens Philippe Joubert Maxime Lamontagne David C Nickle Ma'en Obeidat Wim Timens Bin Zhu Lei Song Linda Kachuri María Soler Artigas Martin D Tobin Louise V Wain Thorunn Rafnar Thorgeir E Thorgeirsson Gunnar W Reginsson Kari Stefansson Dana B Hancock Laura J Bierut Margaret R Spitz Nathan C Gaddis Sharon M Lutz Fangyi Gu Eric O Johnson Ahsan Kamal Claudio Pikielny Dakai Zhu Sara Lindströem Xia Jiang Rachel F Tyndale Georgia Chenevix-Trench Jonathan Beesley Yohan Bossé Stephen Chanock Paul Brennan Maria Teresa Landi Christopher I Amos

Nat Genet 2017 Jul 12;49(7):1126-1132. Epub 2017 Jun 12.

Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.

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http://dx.doi.org/10.1038/ng.3892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5510465PMC
July 2017

Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease.

EBioMedicine 2017 May 12;19:139-145. Epub 2017 Apr 12.

UBC Centre for Heart Lung Innovation, St. Paul's Hospital, Vancouver, British Columbia, Canada; Department of Medicine (Pulmonary Division), University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.04.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440622PMC
May 2017

Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease.

Respir Res 2017 05 2;18(1):77. Epub 2017 May 2.

Respiratory Medicine and Allergology, Department of Clinical Sciences Lund, BMC, D12, Lund University, Skåne University Hospital, 221 84, Lund, Sweden.

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http://dx.doi.org/10.1186/s12931-017-0562-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414362PMC
May 2017

Identification of Susceptibility Genes of Adult Asthma in French Canadian Women.

Can Respir J 2016 4;2016:3564341. Epub 2016 May 4.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec City, QC, Canada G1V 4G5; Department of Molecular Medicine, Laval University, Quebec City, QC, Canada G1V 0A6.

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http://dx.doi.org/10.1155/2016/3564341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904514PMC
March 2017

Transcriptomic Microenvironment of Lung Adenocarcinoma.

Cancer Epidemiol Biomarkers Prev 2017 03 12;26(3):389-396. Epub 2016 Dec 12.

Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada.

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http://dx.doi.org/10.1158/1055-9965.EPI-16-0604DOI Listing
March 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Authors:
Louise V Wain Nick Shrine María Soler Artigas A Mesut Erzurumluoglu Boris Noyvert Lara Bossini-Castillo Ma'en Obeidat Amanda P Henry Michael A Portelli Robert J Hall Charlotte K Billington Tracy L Rimington Anthony G Fenech Catherine John Tineka Blake Victoria E Jackson Richard J Allen Bram P Prins Archie Campbell David J Porteous Marjo-Riitta Jarvelin Matthias Wielscher Alan L James Jennie Hui Nicholas J Wareham Jing Hua Zhao James F Wilson Peter K Joshi Beate Stubbe Rajesh Rawal Holger Schulz Medea Imboden Nicole M Probst-Hensch Stefan Karrasch Christian Gieger Ian J Deary Sarah E Harris Jonathan Marten Igor Rudan Stefan Enroth Ulf Gyllensten Shona M Kerr Ozren Polasek Mika Kähönen Ida Surakka Veronique Vitart Caroline Hayward Terho Lehtimäki Olli T Raitakari David M Evans A John Henderson Craig E Pennell Carol A Wang Peter D Sly Emily S Wan Robert Busch Brian D Hobbs Augusto A Litonjua David W Sparrow Amund Gulsvik Per S Bakke James D Crapo Terri H Beaty Nadia N Hansel Rasika A Mathias Ingo Ruczinski Kathleen C Barnes Yohan Bossé Philippe Joubert Maarten van den Berge Corry-Anke Brandsma Peter D Paré Don D Sin David C Nickle Ke Hao Omri Gottesman Frederick E Dewey Shannon E Bruse David J Carey H Lester Kirchner Stefan Jonsson Gudmar Thorleifsson Ingileif Jonsdottir Thorarinn Gislason Kari Stefansson Claudia Schurmann Girish Nadkarni Erwin P Bottinger Ruth J F Loos Robin G Walters Zhengming Chen Iona Y Millwood Julien Vaucher Om P Kurmi Liming Li Anna L Hansell Chris Brightling Eleftheria Zeggini Michael H Cho Edwin K Silverman Ian Sayers Gosia Trynka Andrew P Morris David P Strachan Ian P Hall Martin D Tobin

Nat Genet 2017 Mar 6;49(3):416-425. Epub 2017 Feb 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681PMC
March 2017

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Nat Genet 2017 Mar 6;49(3):426-432. Epub 2017 Feb 6.

Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381275PMC
March 2017

Genome-wide association study on the FEV/FVC ratio in never-smokers identifies HHIP and FAM13A.

J Allergy Clin Immunol 2017 02 6;139(2):533-540. Epub 2016 Sep 6.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2016.06.062DOI Listing
February 2017

Sex-Related Discordance Between Aortic Valve Calcification and Hemodynamic Severity of Aortic Stenosis: Is Valvular Fibrosis the Explanation?

Circ Res 2017 Feb 22;120(4):681-691. Epub 2016 Nov 22.

From the Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, Canada.

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http://dx.doi.org/10.1161/CIRCRESAHA.116.309306DOI Listing
February 2017

Systolic hypertension and progression of aortic valve calcification in patients with aortic stenosis: results from the PROGRESSA study.

Eur Heart J Cardiovasc Imaging 2017 Jan 18;18(1):70-78. Epub 2016 Feb 18.

Institut Universitaire de Cardiologie et de Pneumologie de Québec/Québec Heart and Lung Institute, Laval University, 2725 Chemin Sainte-Foy, Québec city, Québec, Canada G1V-4G5

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http://dx.doi.org/10.1093/ehjci/jew013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217738PMC
January 2017

Amplification of Adipogenic Commitment by VSTM2A.

Cell Rep 2017 01;18(1):93-106

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Université Laval, Faculté de médecine, 2725 Chemin Ste-Foy, QC G1V 4G5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551894PMC
January 2017

Association between plasma lipoprotein levels and bioprosthetic valve structural degeneration.

Heart 2016 12 4;102(23):1915-1921. Epub 2016 Jul 4.

Laboratory of Cardiovascular Pathobiology, Department of Surgery, Quebec Heart and Lung Institute/Research Center, Laval University, Quebec, Quebec, Canada.

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http://dx.doi.org/10.1136/heartjnl-2016-309541DOI Listing
December 2016

Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1.

Circulation 2016 Dec 27;134(23):1848-1862. Epub 2016 Oct 27.

From Laboratory of Cardiovascular Pathobiology, Quebec Heart and Lung Institute/Research Center, Department of Surgery (F.H., M.-C.B, N.G., S.A., G.M., R.B., M.J.N., P.M.), Department of Molecular Medicine (J.T.M., S.G.-O., Y.B.), and Department of Medicine (P.P.), Laval University, Quebec, QC, Canada; Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada (S.-P.G., L.B.); and ECOGENE-21 and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, Canada (S.-P.G., L.B.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.023116DOI Listing
December 2016

Asthma susceptibility variants are more strongly associated with clinically similar subgroups.

J Asthma 2016 11 8;53(9):907-13. Epub 2016 Apr 8.

a Institut Universitaire de Cardiologie et de Pneumologie de Québec , Québec , Canada.

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http://dx.doi.org/10.3109/02770903.2016.1165699DOI Listing
November 2016

mTORC1 is Required for Brown Adipose Tissue Recruitment and Metabolic Adaptation to Cold.

Sci Rep 2016 11 23;6:37223. Epub 2016 Nov 23.

Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, 2725 chemin Sainte-Foy, Québec, QC, G1V 4G5, Canada.

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http://dx.doi.org/10.1038/srep37223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120333PMC
November 2016

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing.

Physiol Genomics 2016 10 5;48(10):749-761. Epub 2016 Aug 5.

Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec, Canada; Department of Molecular Medicine, Laval University, Quebec, Canada

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http://dx.doi.org/10.1152/physiolgenomics.00041.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195654PMC
October 2016

Total particulate matter concentration skews cigarette smoke's gene expression profile.

ERJ Open Res 2016 Oct 9;2(4). Epub 2016 Nov 9.

Dept of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Hamilton, ON, Canada; Dept of Medicine, Firestone Institute of Respiratory Health at St. Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1183/23120541.00029-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5165723PMC
October 2016

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Authors:
Gordon Fehringer Peter Kraft Paul D Pharoah Rosalind A Eeles Nilanjan Chatterjee Fredrick R Schumacher Joellen M Schildkraut Sara Lindström Paul Brennan Heike Bickeböller Richard S Houlston Maria Teresa Landi Neil Caporaso Angela Risch Ali Amin Al Olama Sonja I Berndt Edward L Giovannucci Henrik Grönberg Zsofia Kote-Jarai Jing Ma Kenneth Muir Meir J Stampfer Victoria L Stevens Fredrik Wiklund Walter C Willett Ellen L Goode Jennifer B Permuth Harvey A Risch Brett M Reid Stephane Bezieau Hermann Brenner Andrew T Chan Jenny Chang-Claude Thomas J Hudson Jonathan K Kocarnik Polly A Newcomb Robert E Schoen Martha L Slattery Emily White Muriel A Adank Habibul Ahsan Kristiina Aittomäki Laura Baglietto Carl Blomquist Federico Canzian Kamila Czene Isabel Dos-Santos-Silva A Heather Eliassen Jonine D Figueroa Dieter Flesch-Janys Olivia Fletcher Montserrat Garcia-Closas Mia M Gaudet Nichola Johnson Per Hall Aditi Hazra Rebecca Hein Albert Hofman John L Hopper Astrid Irwanto Mattias Johansson Rudolf Kaaks Muhammad G Kibriya Peter Lichtner Jianjun Liu Eiliv Lund Enes Makalic Alfons Meindl Bertram Müller-Myhsok Taru A Muranen Heli Nevanlinna Petra H Peeters Julian Peto Ross L Prentice Nazneen Rahman Maria Jose Sanchez Daniel F Schmidt Rita K Schmutzler Melissa C Southey Rulla Tamimi Ruth C Travis Clare Turnbull Andre G Uitterlinden Zhaoming Wang Alice S Whittemore Xiaohong R Yang Wei Zheng Daniel D Buchanan Graham Casey David V Conti Christopher K Edlund Steven Gallinger Robert W Haile Mark Jenkins Loïc Le Marchand Li Li Noralene M Lindor Stephanie L Schmit Stephen N Thibodeau Michael O Woods Thorunn Rafnar Julius Gudmundsson Simon N Stacey Kari Stefansson Patrick Sulem Y Ann Chen Jonathan P Tyrer David C Christiani Yongyue Wei Hongbing Shen Zhibin Hu Xiao-Ou Shu Kouya Shiraishi Atsushi Takahashi Yohan Bossé Ma'en Obeidat David Nickle Wim Timens Matthew L Freedman Qiyuan Li Daniela Seminara Stephen J Chanock Jian Gong Ulrike Peters Stephen B Gruber Christopher I Amos Thomas A Sellers Douglas F Easton David J Hunter Christopher A Haiman Brian E Henderson Rayjean J Hung

Cancer Res 2016 09 20;76(17):5103-14. Epub 2016 Apr 20.

Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493PMC
September 2016

Novel Genetic Susceptibility Loci for FEV1 in the Context of Occupational Exposure in Never-Smokers.

Am J Respir Crit Care Med 2016 09;194(6):769-72

1 University of Groningen, University Medical Center Groningen Groningen, the Netherlands.

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http://dx.doi.org/10.1164/rccm.201603-0646LEDOI Listing
September 2016

Susceptibility genes for lung diseases in the major histocompatibility complex revealed by lung expression quantitative trait loci analysis.

Eur Respir J 2016 08 12;48(2):573-6. Epub 2016 May 12.

Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada Dept of Molecular Medicine, Laval University, Québec, QC, Canada

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http://dx.doi.org/10.1183/13993003.00114-2016DOI Listing
August 2016

The Effect of Statins on Blood Gene Expression in COPD.

PLoS One 2015 13;10(10):e0140022. Epub 2015 Oct 13.

The University of British Columbia Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada; Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140022PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604084PMC
June 2016

Circulating Lp-PLA2 is associated with high valvuloarterial impedance and low arterial compliance in patients with aortic valve bioprostheses.

Clin Chim Acta 2016 Apr 18;455:20-5. Epub 2016 Jan 18.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cca.2016.01.014DOI Listing
April 2016

A pro-inflammatory role for the Frizzled-8 receptor in chronic bronchitis.

Thorax 2016 Apr 21;71(4):312-22. Epub 2016 Jan 21.

Department of Molecular Pharmacology, University of Groningen, Groningen, The Netherlands Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1136/thoraxjnl-2015-206958DOI Listing
April 2016

Epigenetic and genetic variations at the TNNT1 gene locus are associated with HDL-C levels and coronary artery disease.

Epigenomics 2016 Mar 7;8(3):359-71. Epub 2016 Mar 7.

Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.

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http://dx.doi.org/10.2217/epi.15.120DOI Listing
March 2016

Identification of Gender-Specific Genetic Variants in Patients With Bicuspid Aortic Valve.

Am J Cardiol 2016 Feb 19;117(3):420-6. Epub 2015 Nov 19.

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Quebec City, Quebec, Canada; Department of Molecular Medicine, Laval University, Quebec City, Quebec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2015.10.058DOI Listing
February 2016

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels.

J Allergy Clin Immunol 2015 Dec 5;136(6):1664-1672.e14. Epub 2015 Jun 5.

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.03.042DOI Listing
December 2015

Calcium Signaling Pathway Genes RUNX2 and CACNA1C Are Associated With Calcific Aortic Valve Disease.

Circ Cardiovasc Genet 2015 Dec 9;8(6):812-22. Epub 2015 Nov 9.

From the Centre de recherche Institut universitaire de cardiologie et de pneumologie de Québec, Quebec, Canada (S.G.-O., M.L., J.T.-M., E.L.-C., N.G., P.M., P.P., Y.B.); Departments of Molecular Medicine (A.D., Y.B.), Surgery (P.M.), and Medicine (P.P.), Laval University, Quebec, Canada; Cardiology Department, AP-HP, Bichat Hospital, Paris, France (D.M.-Z.); INSERM U698, Paris, France (D.M.-Z.); Département de Génétique, Hôpital Bichat, 75018 Paris, France (C.B.); Centre de Recherche du CHUQ, Quebec, Canada (A.D.); Montreal Heart Institute, Department of Medicine (M.-P.D., J.-C.T.), Université de Montréal, Montreal, Canada (B.J.A.); Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (S.C.B.); and Department of Genetics, Harvard Medical School, Boston, MA (J.G.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.115.001145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934886PMC
December 2015

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.

Nat Commun 2015 Dec 4;6:8658. Epub 2015 Dec 4.

Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.

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http://dx.doi.org/10.1038/ncomms9658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4686825PMC
December 2015

Influences of gestational obesity on associations between genotypes and gene expression levels in offspring following maternal gastrointestinal bypass surgery for obesity.

PLoS One 2015 20;10(1):e0117011. Epub 2015 Jan 20.

Institute of Nutrition and Functional Foods (INAF) and Department of Food Science and Nutrition, Laval University, Quebec, Canada; Endocrinology and Nephrology, CHU de Quebec Research Center, Quebec, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300091PMC
October 2015

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.

J Infect Dis 2015 Oct 22;212(8):1214-21. Epub 2015 Apr 22.

Department of Microbiology Research Centre of Infection and Immunology State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for Infection.

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http://dx.doi.org/10.1093/infdis/jiv246DOI Listing
October 2015

A study in familial hypercholesterolemia suggests reduced methylomic plasticity in men with coronary artery disease.

Epigenomics 2015 ;7(1):17-34

Department of Biochemistry, Université de Sherbrooke, University-Affiliated Chicoutimi Hospital, 305 rue St-Vallier, Saguenay, Québec G7H 5H6, Canada.

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http://dx.doi.org/10.2217/epi.14.64DOI Listing
September 2015

Oxidized Phospholipids, Lipoprotein(a), and Progression of Calcific Aortic Valve Stenosis.

J Am Coll Cardiol 2015 Sep;66(11):1236-1246

Division of Cardiovascular Diseases, Department of Medicine, University of California San Diego, La Jolla, California. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2015.07.020DOI Listing
September 2015

Altered intestinal functions and increased local inflammation in insulin-resistant obese subjects: a gene-expression profile analysis.

BMC Gastroenterol 2015 Sep 16;15:119. Epub 2015 Sep 16.

Department of Nutrition, Université de Montréal and Research center of CHU Sainte-Justine, 3175 Côte Ste-Catherine, Montréal, Qc, Canada.

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http://dx.doi.org/10.1186/s12876-015-0342-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574092PMC
September 2015

Autotaxin Derived From Lipoprotein(a) and Valve Interstitial Cells Promotes Inflammation and Mineralization of the Aortic Valve.

Circulation 2015 Aug 29;132(8):677-90. Epub 2015 Jul 29.

From Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery (R.B., A.M., M.J.N., M.-C.B., J.-L.L., M.-H.L., F.H., P.M.), Department of Medicine (A.D., P.P., B.J.A., A.M.), Department of Pathology (C.C., S.T., S.P.), and Department of Molecular Medicine (Y.B.), Laval University, Québec, Canada; and Department of Chemistry and Biochemistry, University of Windsor, Ontario, Canada (C.A.S., R.R., M.L.K.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.115.016757DOI Listing
August 2015

Carbonic anhydrase XII in valve interstitial cells promotes the regression of calcific aortic valve stenosis.

J Mol Cell Cardiol 2015 May 11;82:104-15. Epub 2015 Mar 11.

Laboratoire d'Études Moléculaires des Valvulopathies (LEMV), Groupe de Recherche en Valvulopathies (GRV), Quebec Heart and Lung Institute/Research Center, Department of Surgery, Laval University, Québec, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.03.002DOI Listing
May 2015

Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).

Sci Rep 2015 Feb 17;5:8517. Epub 2015 Feb 17.

1] State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University [2] Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.

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http://www.nature.com/articles/srep08517
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http://dx.doi.org/10.1038/srep08517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649671PMC
February 2015